| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 541 | Test swab device and method of detecting lead, mercury, arsenic, and bismuth | US750312 | 1991-08-27 | US5330917A | 1994-07-19 | Marcia J. Stone |
| A swab is impregnated with a test reagent such that a test for a specific substance can be effected by rubbing the impregnated swab over the surface to be tested and then viewing the swab for a reagent reaction. A method for testing for a substance includes impregnating a swab with a reagent, and rubbing the swab over a surface suspected of containing the substance. If the substance is present in the surface, a reaction with the substance produces an easily detectable color on the swab tip. | ||||||
| 542 | Method for hydrating and calibrating a sterilizable fiber-optic catheter | US742627 | 1991-08-08 | US5328848A | 1994-07-12 | Conrad T. O. Fong; Mohamed R. Ali Elmesai; Bruce Q. Fieggen |
| The present invention provides an aqueous buffer solution and method and solution for hydrating and calibrating a sensor membrane of a fiber-optic catheter useful for measuring an analyte other than chloride in a physiological milieu. The temperature, gaseous atmosphere, and aqueous buffer solution of the sensor component are controlled throughout the calibration process in order to ensure that the device is calibrated in accordance with its intended use. The solution is chemically compatible with the intended use of the device and provides compensation for evaporative loss, contaminants, or changes in the solution occurring during storage especially in plastic containers. | ||||||
| 543 | Method and compositions for making ACSF and ACSF antagonists | US975960 | 1992-11-13 | US5312810A | 1994-05-17 | William I. Wood; Thomas J. Martin |
| Compositions comprising the C-terminal portion of adenylate cyclase stimulating factor (ACSF) are useful for making ACSF-specific antisera. | ||||||
| 544 | Arylazo chromoionophores | US964860 | 1992-10-22 | US5310888A | 1994-05-10 | Michael L. Bloczynski; Thomas Boecker; Paul F. Corey |
| Disclosed are arylazo chromoionophores characterized by the formula: ##STR1## wherein X is hydrogen or a monovalent cation, Y is H or methoxy and R is a ringed aromatic organic structure which affects the optical absorption properties of the compounds. Also disclosed is a method for the detection of calcium ion using these compounds. | ||||||
| 545 | Chromatography processes using doped sol gel glasses as chromatographic media | US774104 | 1991-10-11 | US5308495A | 1994-05-03 | David Avnir; Michael Ottolenghi; Ovadia Lev |
| Chromatography processes employ doped sol gel glasses as chromatographic media. In one embodiment, a process for qualitative or quantitative determination of a reactive chemical contained in a sample comprises passing the sample through a column or planar chromatography apparatus wherein the apparatus includes packing or plates containing a porous doped sol gel glass. The doped sol gel glass is formed form a metal alkoxide and contains a compound encapsulated therein which is reactive with the reactive chemical in the pores of the doped sol gel glass. In another embodiment, a process for analyzing a gas sample containing a reactive chemical comprises passing the gas sample through glass capillaries or tubes containing porous doped sol gel glass pellets. The pellets are formed from a metal alkoxide and contain a colorimetric reagent encapsulated therein which is reactive with the reactive chemical in the pores of the pellets. In a third embodiment, a doped sol gel glass is included in the chromatographic media for pretreatment cleanup for interference removal prior to the chromatographic separation. | ||||||
| 546 | Doped sol-gel glasses for obtaining chemical interactions | US637873 | 1991-01-08 | US5300564A | 1994-04-05 | David Avnir; Michael Ottolenghi; Sergei Braun; Rivka Zusman |
| A method is proposed of obtaining a chemical interaction between at least one reagent trapped in sol-gel glass by doping it with the reagent, and diffusible solutes or components in an adjacent liquid or gas phase. The reagents, the solutes or the components can be any organic or inorganic compounds or materials of biological origin including enzymes. The doped sol-gel glass in various forms may be useful as analytical test, chromatographic medium, sensor, catalyst or biocatalyst, electrode or enzyme electrode, or other detection device. | ||||||
| 547 | Doped sol-gel glasses for obtaining chemical interactions | US937258 | 1992-08-31 | US5292801A | 1994-03-08 | David Avnir; Michael Ottolenghi; Sergei Braun; Riyka Zusman |
| A method is proposed of obtaining a chemical interaction between at least one reagent trapped in sol-gel glass by doping it with the reagent, and diffusible solutes or components in an adjacent liquid or gas phase. The reagents, the solutes or the components can be any organic or inorganic compounds or materials of biological origin including enzymes. The doped sol-gel glass in various forms may be useful as analytical test, chromatographic medium, sensor, catalyst or biocatalyst, electrode or enzyme electrode, or other detection device. | ||||||
| 548 | Tetra substituted cyclohexane composition | US799566 | 1991-11-27 | US5290950A | 1994-03-01 | Morton Raban; David T. Durocher |
| Disclosed is a tetra substituted cyclohexane having an ionophore in the one and two positions wherein the ionophore may be the same or different and is selected from the group consisting of a crown, a podand and a cryptand wherein the ionophore is capable of complexing with a metal or ammonium cation. Positions four and five are substituted by an electron donor group and an electron acceptor group. Also disclosed is a method for detecting the concentration of cations in a fluid by subjecting the fluid to the tetra substituted cyclohexane composition which will thereby complex the cation in the fluid. The cations are preferably alkali metal and alkaline earth metal cations. The fluid may be an aqueous or non-aqueous fluid or body fluids. | ||||||
| 549 | Reagent for the determination of chlorine ion | US713007 | 1991-06-10 | US5229270A | 1993-07-20 | Toshihiro Ono; Junichi Taniguchi |
| Quantitative assay and reagent for the determination of chlorine ion in body fluid. Body fluid is contacted with a reagent which includes deactivated .alpha.-amylase, a compound capable of chelating calcium ion, a calcium chelate compound, and an .alpha.-amylase activity-measuring substance; the amount of .alpha.-amylase activity is proportional to the amount of chlorine ion present in the body fluid. The assay is suitable for automation. | ||||||
| 550 | Process for the determination of iron | US750766 | 1991-08-22 | US5219760A | 1993-06-15 | Uwe Herrmann; Jurgen Ruhm |
| To determine iron in serum by the release of bound iron and reduction of the released iron to Fe.sup.2+, a first solution of a denaturing agent at a concentration of 1 to 8 mol/l is added to the serum, then a second solution is added which contains the color reagent and likewise a denaturing agent at a concentration of 1 to 8 mol/l and subsequently the colored complex is measured photometrically. | ||||||
| 551 | Method and composition for magnesium ion detection using hydroxy-substituted cyanoformazans | US716587 | 1991-06-17 | US5215925A | 1993-06-01 | Bruce E. Babb; David A. Hilborn |
| 1,5-Bis(2-hydroxyphenyl)-3-cyanoformazans substituted in at least one of the 3-, 4- and 5-positions of either phenyl moiety are useful for the determination of magnesium ions. The cyanoformazan substituents are chosen such that their cumulative Hammett-sigma value is greater than about 0.23. These cyanoformazans are useful in analytical compositions and methods for either wet or dry assay of magnesium ions. | ||||||
| 552 | Methods and apparatus for quantifying tissue damage, determining tissue type, monitoring neural activity, and determining hematocrit | US561986 | 1990-08-02 | US5200345A | 1993-04-06 | Wise Young |
| Tissue damage may be quantified, tissue type identified, neural activity monitored or blood hematocrit determined by measuring the difference between the total tissue sodium and potassium concentrations in the area in question. Comparison of these measurements with standard values permit evaluation of the amount of tissue damage in cells of the same type or the tissue type in non-necrotic cells. Evaluation over time of normal brain cells permit monitoring of neural activity. By directly and simultaneously measuring sodium and potassium ion concentrations, for example, a nuclear magnetic resonance spectrometer can image areas of different tissue type in differing colors. In this manner tumors and lesions can be clearly delineated. Measurement of total potassium concentration of a blood sample and the potassium concentration of the cell-free plasma will permit determination of cellular volume fraction (hematocrit). | ||||||
| 553 | Determination of actinides in urine and fecal samples | US831017 | 1992-02-04 | US5190881A | 1993-03-02 | Terry T. McKibbin |
| A method of determining the radioactivity of specific actinides that are carried in urine or fecal sample material is disclosed. The samples are ashed in a muffle furnace, dissolved in an acid, and then treated in a series of steps of reduction, oxidation, dissolution, and precipitation, including a unique step of passing a solution through a chloride form anion exchange resin for separation of uranium and plutonium from americium. | ||||||
| 554 | Colorimetric method and reagent for the assay of lithium in a test sample | US648073 | 1991-01-31 | US5187103A | 1993-02-16 | Bronislaw P. Czech; Eddy Chapoteau; Anand Kumar |
| A chromogenic cryptand found to be especially selective in the determination of lithium in blood of the general formula (I): ##STR1## where: n=1 or 2,R.sub.1 and R.sub.2, same or different, are hydrogen, lower alkyl, lower alkenyl, or lower alkylidene; andQ is a chromogenic moiety capable of providing a detectable response upon complexation of said compound with lithium ion and has the structure: ##STR2## wherein: X is CH, C--OH or N; and Z is p-nitrophenylazo, 2,4-dinitrophenylazo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino, bis-(4-dimethylaminophenyl) hydroxymethyl, 3-phenylisothiazolyl-5-azo, thiazolyl-5-azo; or isothiazolyl-5-azo.A reagent composition and synthesis of a preferred chromogenic cryptand are also disclosed. | ||||||
| 555 | Dry analysis element for the analysis of iron ions | US780740 | 1991-10-18 | US5186894A | 1993-02-16 | Harumi Katsuyama |
| A dry analysis element for the analysis of iron ions, which is improved in selectivity so that iron ions can be analyzed reliably at a high sensitivity without the interferences by the presence of hindering Cu.sup.2+ and/or Zn.sup.2+ ions. The analysis element comprises a detection reagent layer containing Nitro-PAPS acting as a chelating agent and a cationic compound, and a pre-treating layer containing a Cu.sup.2+ -specific chelating agent. The analysis element further includes a pH buffer for keeping the pH value of the detection reagent layer within the range of from pH 3.0 to 5.0. The pH adjusting buffer may be contained in either one of the detection reagent layer or the pre-treating layer, or may be contained in another layer. The detection reagent layer may be composed of a coloring reagent layer containing Nitro-PAPS acting as the chelating agent, and a diffusion-preventing layer laminated on the coloring reagent layer and containing the cationic compound. | ||||||
| 556 | Test device for detecting glucose, protein urobilinogen, and/or occult blood in body fluids and/or determining the PH thereof | US349950 | 1989-05-08 | US5183742A | 1993-02-02 | Kouichi Omoto; Takeshi Miyazaki |
| A test device having the following meritorious effects is obtained in accordance with the present invention by using at least one composition selected from the group consisting of ink compositions for detecting glucose, for detecting protein, for detecting urobilinogen, and for detecting occult blood in a body fluid, and for detecting the pH thereof:a) The test device is stable during storage in atmospheric air for a long period of time, presenting no discoloration phenomenon;b) The test device has high sensitivity coupled with excellent measurement performance;c) The regions for detecting glucose and the other body fluid ingredients and the pH can be formed directly on the surface of the test device by printing, allowing the test device to be formed by mass production and the process steps to be reduced; andd) The ink compositions for detecting glucose, etc. are stable, and can be handled easily. | ||||||
| 557 | Ion selective fluorogenic reagents | US88370 | 1987-08-24 | US5136033A | 1992-08-04 | Divakaran Masilamani; Mariann E. Lucas; George S. Hammond |
| Novel fluorogenic ionophores have been synthesized which selectively bind ions such as potassium and sodium, even in neutral aqueous and alcoholic media and respond to such binding by fluorescence quenching or enhancement. These ionophores are ideal for the selective and direct determination of ions in biological or environmental samples and the like. The ionophores are also suitable for incorporation into fiber optic-based sensors for the continuous in vivo or in vitro monitoring of metal ions in blood or other biological fluids. | ||||||
| 558 | Indirect potentiometric method and diluent for analysis of lithium | US600453 | 1990-10-19 | US5110742A | 1992-05-05 | Frank R. Shu; Chen-Yie Chien; Julie S. Kim |
| An indirect potentiometric method and diluent for the analysis of lithium are disclosed. The diluent includes effective amounts of a pH buffer, at least one lithium salt, and a non-cationic surfactant containing at least one hydrophobic group, at least one hydrophillic group and being substantially free of polyoxyethylene groups. Most preferably, the pH buffer is tris-(hydroxymethyl)aminomethane-phosphate, the lithium salt is lithium chloride, and the surfactant is 2,4,7,9-tetramethyl-5-decyn-4,7 diol. An indirect potentiometric determination of lithium in a clinical sample comprises the steps of mixing the sample with a diluent, contacting an aliquot of the diluted sample with a lithium specific ion selective electrode and at least one ion selective electrode specifically responsive to a monovalent interfering ion, and measuring both the response of the lithium specific ion selective electrode and the monovalent interfering ion specific ion selective electrode, the responses being an indication of the concentration of lithium in the sample. | ||||||
| 559 | Ionic component sensor and method for making and using same | US503838 | 1990-04-03 | US5081041A | 1992-01-14 | Masao Yafuso; Evan A. Thompson; John L. Dektar; James F. Fagan; Sanjay L. Patil |
| A composition of matter useful in a sensor for sensing the concentration of an ionic component in a medium is disclosed. This composition comprises a first material which includes a sensing component in an amount effective to provide a signal which varies as the concentration of the ionic component in the medium varies, and a first matrix material which is permeable to the ionic component; and a second material which includes a second matrix material which is permeable to the ionic component, and an opaque agent in an amount sufficient to render the second material effectively opaque. The first material matrix and the second matrix material are covalently bonded together. Sensing apparatus including such composition of matter and methods for making and using such composition of matter are also disclosed. | ||||||
| 560 | Method for determining the concentration of cations in a sample | US304356 | 1989-01-30 | US5073501A | 1991-12-17 | Eddy Chapoteau; Bronislaw P. Czech; Carl R. Gebauer; Koon-Wah Leong; Anand Kumar |
| The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent including one or more chromogenic cryptand compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5;m and n, either same or different, are equal to 0 to about 4;a and e, either same or different, are equal to 0 to about 2;b and d, either same or different, are equal to 0 to about 5;R, either same or different, is hydrogen.lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and-Q- is ##STR2## wherein X is CH, N, or COH; and Y includes ##STR3## except that when Q is ##STR4## wherein Y is p-nitrophenylazo, 3-phenylisothiazolyl-5-azo, isothiazolyl-5-azo, thiazolyl-5-azo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino or bis-(p-dimethylaminophenyl)hydroxymethyl, then the following condition cannot be present: that simultaneously b is equal to 0 or 1, d is equal to 0 or 1, j is equal to 1, n is equal to 1 or 2, a is equal to 1, e is equal to 1, k is equal to 1 and m is equal to 2. | ||||||
QQ群二维码
意见反馈
意见反馈