| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 581 | Non-invasive diagnosis method | US338365 | 1982-01-11 | US4457748A | 1984-07-03 | Gary A. Lattin; Richard P. Spevak |
| This invention provides a method for performing a simple "sweat test" with particular use in screen testing for cystic fibrosis. The method includes the use of an iontophoretic device adapted for ambulatory use which has a self-adhesive drug-impregnated electrode for the stimulation of sweat coupled with the subsequent use of a test patch device for performing the analysis of the sweat in situ. For cystic fibrosis diagnosis, the test patch is particularly adapted to determine chloride concentration in the sweat when the concentration exceeds a predetermined level. | ||||||
| 582 | Determination of the acid-base status of blood | US364665 | 1982-04-02 | US4454229A | 1984-06-12 | Rolf Zander; Hans U. Wolf |
| In order to simplify the operation for determination of the acid-base status of blood, composed of the values for pH, pCO.sub.2 and the base excess BE, the base excess BE is determined through measurement of the pH-value at a pCO.sub.2 of about 0 mm Hg. The pH-values may be determined photometrically, in which case the indicator solution for measuring the actual blood-pH is an aqueous solution of 40 micromol/l bromthymol blue plus 0.2 g/l sodium dodecylsulfate plus 1% ethanol; and for measurement of the base excess BE is an aqueous solution of 65 micro mol/l naphtholphthalein plus 0.2 g/l sodium dodecylsulfate plus 15% dimethylsulfoxide, which are measured at a wavelength of 635 nm. If desired, one may use a single solution for measuring both actual blood-pH as well as the base excess BE, composed of 16 micromol/l bromthymol blue plus 34 micromol/l naphtholphthalein plus 0.15 g/l sodium dodecylsulfate, which is measured at 615 nm wavelength. | ||||||
| 583 | Fluid absorbent quantitative test device | US338274 | 1982-01-11 | US4444193A | 1984-04-24 | Eric J. Fogt; Marye S. Norenberg; Darrel F. Untereker; Arthur J. Coury |
| An absorbent quantitative test device in the form of a flat patch. When placed on the skin of a subject; the device collects a fixed volume of sweat. It is particularly intended to be used in screen testing for cystic fibrosis by measuring the chloride level in sweat and providing a visual indication when the level is in excess of a predetermined concentration. A fill tab indicator undergoes a color change when the fixed volume of sweat has been collected signifying completion of the test. The device includes two concentric circular reaction areas of chemically treated absorbent paper or the like. The sweat sample is introduced into the device at the center of the first or inner circular reaction area which contains a chemical composition capable of reacting with all chloride in the sweat sample below a predetermined concentration value to screen out that amount of chloride. A second or outer ring-shaped reaction area contains a chemical composition which indicates a color change for any chloride reaching it in excess of the predetermined concentration value. The color change in the outer ring-shaped portion thereby provides a quantitative indication of the presence of a concentration of chloride in the subject' s sweat in excess of the predetermined concentration level. | ||||||
| 584 | Simultaneous, kinetic, spectrophotometric analysis of blood serum for multiple components | US198796 | 1980-10-20 | US4425427A | 1984-01-10 | Thomas K. J. Luderer |
| Method, kits and reagents for the simultaneous, kinetic spectrophotometric analysis of blood serum samples for multiple components. Pairs of components which may be simultaneously analyzed are: cholesterol and triglyceride; glucose and urea; uric acid and gamma glutamyl transferase; calcium and magnesium; albumins and total protein. | ||||||
| 585 | Method and apparatus for chemical analysis using reactive reagents dispersed in soluble film | US204112 | 1980-11-05 | US4387164A | 1983-06-07 | Richard C. Hevey; Ronald D. Forget |
| Automated chemical analytical method and device in which a precise measured quantity of reagent is combined with an assay medium. Prior to such delivery, the reagent, being water-soluble or dispersible, is contained within carrier solid organic binder which is fixed within and constitutes part of the device. Upon addition of an aqueous medium, the carrier binder is dissolved or dispersed, the protected precise measured quantity of reagent is concomitantly released and dissolved. | ||||||
| 586 | Calcium assay | US311177 | 1981-10-14 | US4382122A | 1983-05-03 | Louis M. Mezei; Laurence N. Jacobs; Samuel C. Berry |
| The stability of a reagent comprising an aqueous solution of a phenolsulphonephthalein dye is enhanced by the presence of a weak acid in the reagent. | ||||||
| 587 | Ligands assayed by host molecules including cyclophanes, crown ethers, crypstands and podands | US78738 | 1979-09-25 | US4367072A | 1983-01-04 | Friedrich Vogtle; Johannes P. Dix; Dieter Jaworek |
| Method for the determination of a component in a liquid which component is selected from ions, polar substances lipophilic substances, which comprises contacting a liquid sample containing said component with, and allowing same to act upon, a complex ligand or host molecule which is selective toward the component, said complex ligand or host molecule being bonded to a chromophore material, and measuring the change of extinction or the wavelength displacement of the resulting mixture as a measure of the initial content of said component; corresponding reagent test kits are also provided. The complex ligands or host molecules include cyclodextrins, cyclophanes, crown ethers, cryptands, podands valinomycin, gramacidin and monactin. | ||||||
| 588 | Continuous release of reagent in an analytical element to reduce assay interference | US169704 | 1980-07-17 | US4333733A | 1982-06-08 | Karl J. Sanford; Jon N. Eikenberry |
| Analytical elements and methods for the selective determination of an analyte in aqueous fluids containing the analyte. These elements and methods feature means for continuously releasing chromogenic indicator reagent from a reagent zone to a reaction zone. The continuous release means is responsive to the application of a sample of the fluid to continuously release reagent into the reaction zone at a rate producing color response corresponding to interaction of the indicator with the analyte and reduced interaction of the indicator with interferents. In preferred embodiments, albumin is determined in the presence of interfering proteins such as globulins using buffered chromogenic indicator reagent. In such embodiments, when protein interferents are present, their interference can be substantially eliminated for up to three minutes, during which time color response is substantially only from the interaction of albumin and reagent. The determination of albumin follows from such color response. | ||||||
| 589 | Test composition, method and a test stick for detection of chloride ion in cow's milk | US924376 | 1978-07-13 | US4211532A | 1980-07-08 | Shizen Tobari; Mariko Nakano |
| Test composition and test stick for detection of chloride ion in cow's milk, which composition comprises a protected silver chromate colloidal substance, a surface active agent and a buffer agent having a pH value ranging from 2 to 7, and which test stick comprises a carrier, protected silver chromate colloidal substance, a surface active agent and a buffer agent having a pH value ranging from 2 to 7; and a method for producing the test stick. | ||||||
| 590 | Reagent and method for determination of phosphorous | US687354 | 1976-05-17 | US4009004A | 1977-02-22 | Marvin E. Hutchinson, Jr. |
| A method and reagent for the determination of inorganic phosphate in biological fluids by the reduction of molybdenumphosphate with a reducing agent, a non-ionic lineating surfactant, an acid, and optionally polyvinylpyrrolidone (PVP), wherein the sample used in the test method need not be protein free. | ||||||
| 591 | Process for determining the concentration of inorganic phosphates in human fluids | US30705972 | 1972-11-16 | US3874853A | 1975-04-01 | BYRNES RONALD K |
| In a testing procedure for determining the concentration of a organic phosphate in human fluids by determining the amount of light absorbance of a chromogen in a test sample formed by reacting the phosphate with at least two reagents in two separate steps, a true blank is prepared having a light absorbance representative of all the constituents in the sample other than the chromogen. The true blank is prepared by adding the same reagents to a blank sample in a sequence different from that used for the test sample so that the conditions under which the chromogen is formed are avoided in the blank sample.
|
||||||
| 592 | Reagent and method for calcium determination | US28488472 | 1972-08-30 | US3822116A | 1974-07-02 | MORIN L |
| A METHOD AND REAGENT FOR THE DETERMINATION OF CALCIUM IN BIOLOGICAL FLUIDS BY THE COMPLEX FORMATION WITH O-CRESOLPHTHALEIN COMPLEXION IN AN ALKALINE AMPHIPROTIC BUFFER IS DISCLOSED.
|
||||||
| 593 | Agent and method for determination of calcium | US3798000D | 1972-08-14 | US3798000A | 1974-03-19 | HELGER R |
| An agent for the colorimetric determination of calcium, containing a color reagent, which forms complexes in the presence of calcium ions, and a buffer system which consists essentially of a mixture of amidosulfonic acid, disodium tetraborate and alkali carbonate.
|
||||||
| 594 | Automated direct method for the determination of inorganic phosphate in serum | US3795484D | 1971-12-22 | US3795484A | 1974-03-05 | ERTINGSHAUSEN G; DALY J |
| A direct method is provided for the spectrophotometric determination of inorganic phosphate in fluids, particularly body fluids, such as blood serum. The process requires only a single reagent addition and comprises reacting the phosphate-containing fluid with an ammonium molybdate solution and thereafter measuring the absorbance within a specified time interval before the reaction has measurably proceeded and at the end of the reaction by means of a centrifugal analytical photometer. Inasmuch as a linear relationship exists between the phosphate concentration and the change of absorbance, the concentration is an unknown sample can be conveniently calculated by comparison with the results obtained from the simultaneous measurement of a sample of known concentration.
|
||||||
| 595 | Colorimetric determination of calcium in biologic fluids | US3754865D | 1972-01-05 | US3754865A | 1973-08-28 | GINDLER E |
| Methylthymol blue dye in colorimetrically analyzing a biologic fluid such as blood serum for calcium content. Analysis can be accomplished in the presence of proteins, phosphates and bilirubin. 8-Quinolinol can be used to bind magnesium without an accompanying adverse effect on the measurement of calcium concentration. Color stable aqueous solutions of the dye are also provided as well as color stability of the calcium-dye complex during analysis.
|
||||||
| 596 | Cerebrospinal fluid control standard | US3753925D | 1972-03-24 | US3753925A | 1973-08-21 | LOUDERBACK A; FONTANA A |
| A SYNTHETIC CONTROL STANDARD FOR THE DETERMINATION OF CERBROSPINAL FLUID CONSTITUENTS IS PROVIDED BY DILUTING NORMAL BLOOD SERUM WITH AN AQUEOUS SOLUTION OF GLUCOSE AND SALINE TO A TOTAL PROTEIN CONCENTRATION OF 30 TO 145 MG. PER 100 ML.
|
||||||
| 597 | Diagnostic paper strip | US3598533D | 1969-04-01 | US3598533A | 1971-08-10 | TOMIOKA SUIICHI; SHIBA MOTOHARU; WADE SAKAE |
| AN IMPROVED DIAGNOSTIC PAPER STRIP WHICH IS APPLICABLE TO WHOLE BLOOD SAMPLE, WHICH IS PREPARED BY DIPPING A DIAGNOSTIC PAPER STRIP INTO ORGANIC SOLVENT SOLUTION OF ONE OR MORE OF CHOLESTEROL, ROSIN AND THEIR ESTERS AND DRYING THE STRIP.
|
||||||
| 598 | 2-(p-dimethylamino styryl)-1-methylquinolinium chloride as an analyzer for iodine | US3592604D | 1969-01-23 | US3592604A | 1971-07-13 | COTTRELL WILLIAM N JR |
| 2-(P-DIMETHYLAMINO STYRYL)-1-METHYLQUINOLINIUM CHLORIDE WHICH IS PRODUCED BY THE REACTION OF QUINALDINE, METHYLENE CHLORIDE AND P-DIMETHYLAMINO BENZALDEHYDE IN THE PRESENCE OF ETHYL ALCOHOL AND SULFURIC ACID. THIS COMPOUND IS USED AS AN INDICATOR FOR INORGANIC AND ORGANIC BOUND IODINE IN BODY FLUIDS.
|
||||||
| 599 | Reagent solutions for use in serum bicarbonate and chloride analysis | US3551350D | 1968-03-20 | US3551350A | 1970-12-29 | DAHMS HARALD |
| 600 | Method and apparatus for the titration of chloride and bicarbonate in serum | US3551109D | 1967-12-13 | US3551109A | 1970-12-29 | DAHMS HARALD |
| A method and apparatus useful for colorimetric titration utilizes an indicator which changes from one colored form to another at or near an endpoint, and an optical endpoint detection system which generates signals responsive to the relative concentrations of the different colored forms of the indicator. The endpoint is indicated when the ratio of the logarithms of the signals reaches a predetermined value. | ||||||
QQ群二维码
意见反馈
意见反馈