| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 221 | Sulfonyl compound used as a linker in solid phase synthesis and combinatorial synthesis | JP52981098 | 1997-12-17 | JP2001508426A | 2001-06-26 | 秀雄 津々美; 明人 田中 |
| (57)【要約】 この発明は、下記の式（Ｉ） ［式中、Ｒ 1は、式（Ａ） ［式中、Ｒ 3 、Ｒ 4およびＲ 5は、同一または異なる水素などをそれぞれ意味する。 ］、で表される基など、Ｒ２は、樹脂との化学結合を形成可能な基であり、慣用の保護基で保護されていてもよい、Ａは低級アルキレン基など、Ｘは脱離基、ｍは０または１の整数を意味し、ただし、Ｒ 1が式（Ａ）で表される基である場合、Ａは（Ｃ 2 −Ｃ 6 ）アルキレン基、ｍは整数１を意味する。 で表されるリンカーに関する。 | ||||||
| 222 | Affinity-type self-assembly systems, as well as photonics and electronics for the element | JP52877198 | 1997-11-26 | JP2001506931A | 2001-05-29 | エセナー，サディック・シー; ケーブル，ジェフリー・エム; ヘラー，マイケル・ジェイ |
| This invention relates to techniques which utilize programmable functionalized self-assembling nucleic acids, nucleic acid modified structures, and other selective affinity or binding moieties as building blocks. The invention is a method for the fabrication of micro scale and nanoscale devices comprising the steps of: fabricating first component devices on a first support, releasing at least one first component device from the first support, transporting the first component device to a second support, and attaching the first component device to the second support. The invention also provides for orienting a structure in an electric field, reacting affinity sequences, and assembling chromophoric structures by photoactivation. | ||||||
| 223 | Liquid particle injection apparatus and method of using the same | JP54250497 | 1997-05-13 | JP2000513266A | 2000-10-10 | ガンブル、ロナルド・シー; セリオウルト、トーマス・ピー; ボールドシュイーラー、ジョン |
| (57)【要約】 マイクロスポットのアレイを精密に低減させるための装置及び方法。 パルス噴射装置は、ミクロンサイズの細管１６を有しており、細管の一部が圧電変換器５６によって外囲された噴射オリフィス６０に近接している。 細管１６、オリフィス６０、及び圧電変換器５６の適切な設計により、液体粒子が、中心間距離がわずか８０ミクロン、境界における間隔が少なくとも約１５ミクロンとなるように分離された形態で表面上に形成され得る。 本発明の基板アレイを、サンプルにおける相同な配列の存在の検出を目的とした、例えば核酸のような試薬の小型化されたアレイを準備するために用いることができる。 | ||||||
| 224 | Sequential solid-phase organic synthesis for the apparatus and methods of use thereof | JP26938098 | 1998-09-24 | JP3090908B2 | 2000-09-25 | エイ ホーテン リチャード |
| 225 | Isoquinoline derivatives and isoquinoline combination library | JP51738397 | 1996-10-18 | JPH11514645A | 1999-12-14 | エス． キーリー，ジョン; シー． グリフィス，マイケル |
| (57)【要約】 本発明は、イソキノリン環に基づくヘテロ環式化合物の合成を提供する。 より詳細には、本発明は、新規なイソキノリンならびにそのような多くの化合物からなる新規なライブラリ化合物、およびそのライブラリの合成方法を提供する。 | ||||||
| 226 | Sequential solid phase organic synthesizer and its use | JP26938098 | 1998-09-24 | JPH11180995A | 1999-07-06 | HOUGHTEN RICHARD A |
| PROBLEM TO BE SOLVED: To perform an organic solid phase synthesis of polypelptide or the like by simultaneously adding individual subunits to the subunits linked to a plurality of resin particles, respectively. SOLUTION: (A) The mixture in the synthesize is mixed with excessive amounts of the same subunits that contain (i) the second reactive functional group that can react with an eliminatively reactive functional group in the subunits linking to the resin particles and contains (ii) other reactive functional group protected from the reaction by the covalent protecting group that can react during the synthesis, but selectively removable. (B) A covalent bond is formed between the eliminative reactive functional group and the second reactive functional group, the mixed subunits are linked to the particles so that the distal subunits form a plurality of synthesizers including reaction products linking to the particles containing selective removably protected group. (C) The mixed unreacting subunits are separated from the reaction products connected to particles, finally (D) A plurality of synthesizers are mutually separated therefrom. | ||||||
| 227 | Sequential solid-phase organic synthesis for the apparatus and methods of use thereof | JP6702486 | 1986-03-25 | JP2894688B2 | 1999-05-24 | RICHAADO EI HOOTEN |
| 228 | Combinatorial libraries with an amino diol monomer subunits | JP50188797 | 1996-06-07 | JPH10509185A | 1998-09-08 | ハーバート，ノーマンド |
| (57)【要約】 ホスホジエステル、ホスホロチオエート、またはホスホルアミデート結合成分により連結されたアミノジオールモノマーサブユニットを含むコンビナトリアルライブラリが構築される。 本発明のコンビナトリアルライブラリは、主鎖およびホスホルアミデートコンビナトリアル部位に結合した複数の官能基を特徴とする。 | ||||||
| 229 | Reaction vessel | JP23715391 | 1991-08-24 | JP2787963B2 | 1998-08-20 | NOKIHARA SEISHI |
| 230 | Method and apparatus for performing multi-step sequential reaction in the matrix | JP52412695 | 1995-03-14 | JPH09510452A | 1997-10-21 | シー． ガンブル，ロナルド; ピー． テリオールト，トマス; ディー． バルデシュウィーラー，ジョン |
| (57)【要約】 化学的化合物が合成されるかまたは診断的試験が実施される微小液滴サイズの反応ローカスがその上に局在する基板を調製する方法および装置が提供される． これらの反応ローカスは，微小液滴をパルス供給する供給装置から基板の表面上に適用することによって形成される． | ||||||
| 231 | Polymer synthesis apparatus and method using an array | JP51219195 | 1994-10-19 | JPH09507505A | 1997-07-29 | トーマス エム ブレナン |
| (57)【要約】 ポリマー鎖を形成するためのポリマー合成法および装置(20)が開示され、該装置は各々液状試薬(24)のタンク(23)に連結されたノズル(22)をもつヘッドアセンブリー(21)と、反応ウエル(26)を有するベースアセンブリー(25)とを含む。 該ノズル(22)の上流側の該共通のチャンバー(31)への入口(70)および該ノズル(22)の下流側の該共通のチャンバー(31)からの出口(71)が、該共通のチャンバー(31)から、該試薬により放出される有害な煙霧を掃気する。 圧力調節デバイス(82)が設けられ、これは、該反応ウエル(26)に及ぼされる圧力と該オリフィス(74)の出口(80)に及ぼされる圧力との間の差圧を、該差圧が予め定められた値を越えた場合に、該試薬溶液(76)を追い出すように制御する。 | ||||||
| 232 | Solid phase peptide synthesis for Cleavage processing unit | JP4331292 | 1992-02-28 | JPH0794468B2 | 1995-10-11 | 伸 中村; 林太郎 山本; 清史 軒原 |
| 233 | JPH07506561A - | JP50956793 | 1992-11-20 | JPH07506561A | 1995-07-20 | |
| 234 | Cleavage apparatus | JP6333793 | 1993-02-26 | JPH06256384A | 1994-09-13 | NOKIHARA SEISHI |
| PURPOSE: To obtain a cleavage apparatus, composed of a specific construction so as to circulate and use a cleavage cocktail in a closed system and capable of readily, safely, rapidly and surely carrying out the cleavage of a peptide in large amount at a low cost. CONSTITUTION: This cleavage apparatus is equipped with cleavage cocktail transporting lines (3) and (4) for transporting a cleavage cocktail from a flask 3 into a column 1 having a resin-protected peptide combination after synthesizing a peptide chain and simultaneously recovering the cleavage cocktail from the column 1 in the flask 3. Furthermore, a mixture prepared by mixing reagents for cleaving the resin-protected peptide combination such as trifluoroacetic acid (TFA), anisole, dimethyl sulfide or phenol is usually used as the cleavage cocktail. In order to recover the cleavage cocktail from the column, e.g. nitrogen gas 8 is pressurized to flow into the column 1, thereby the cocktail is passed through the cleavage cocktail transporting lines (4) and (3) and then returned to the flask 3. COPYRIGHT: (C)1994,JPO&Japio | ||||||
| 235 | Novel sulfinamide derivative, its production and medicine containing the same | JP27900291 | 1991-07-31 | JPH05279319A | 1993-10-26 | Gilles Chavernac; Francois Collonges; Daniel Guerrier; Claude Lardy; ゲリエ・ダニエル; コロンジユ・フランソワ; シヤベルナツク・ジレー; ラルデイ・クロード |
| PURPOSE: To provide a new sulfonamide deriv. which strongly suppresses the biological activity of TXA 2 and is used for the treatment and prevention of ischemia, cerebrovascular diseases, peripheral vascular diseases and lipid imbalance, allergic diseases and inflammations. CONSTITUTION: The compd. of formula I [R 1 is an aryl, heterocyclic group; one of R 2, R 3 is W and the other is H, a halogen, CF 3, alkyl cycloalkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonylacyl, thioacylhydroxyl, NH 2, NO 2, CN, azide, aryl; R 4 to R 7 are R 2, R 3 exclusive of W; W is Z-Ar-(CH 2) q-A (A is CO 2H, SO 3H, etc.; (q) is 0 to 4; Ar is an aryl, arom. heterocyclic group; Z is O, CH 2, coupler); Y is (CH 2) 3-B-(CH 2) t ((s), (t) are 0 to 2; B is O, S, N, CO, CS, etc.); (n) is 0, 1]; for example, trans-4-[(2-[[(4-chlorophenyl)sulfonyl]-amino]cyclopentyl) methyl]benzeneacetic acid. The compd. is obtd. by the reaction of the compds. of formula II and terminal III. COPYRIGHT: (C)1993,JPO | ||||||
| 236 | Cleavage treatment device for peptide synthesis by solid phase method | JP4331292 | 1992-02-28 | JPH05239089A | 1993-09-17 | NAKAMURA SHIN; NOKIHARA SEISHI; YAMAMOTO RINTARO |
| PURPOSE: To obtain a subject device capable of enhancing efficiency of cleavage treatment and simultaneously capable of treating a number of peptides by providing a reaction chamber for carrying out peptide synthesis by a solid phase method, a drain port, a reaction vessel having a filter for partitioning the reaction chamber and the drain port and a pressurizing device. CONSTITUTION: In synthesizing a peptide using a solid phase peptide synthesizer 1 composed mainly of a cleavage treatment device 2, a reagent feeding device 3 and a drain device 4, the objective device 2 is used for separating a peptide bound to a solid phase support from the solid phase support. This cleavage treatment device 2 is equipped with a reaction chamber 11 capable of carrying out peptide synthesis by a solid phase method, a drain port 8 provided with a stopper member 9 for hermetical sealing, a reaction vessel 5 having a filter 10 capable of partitioning the reacting chamber 11 and the drain port 8 and supporting a solid phase support, a pressurizing device 6 for pressurizing the interior of the reaction chamber 11. According to this cleavage treatment device, only a cleavage reagent in which the peptide is dissolved is discharged to the outside by enhancing the inner pressure of the reaction chamber 11 with the pressurizing device 6 and a synthesized peptide is treated in high treating efficiency. COPYRIGHT: (C)1993,JPO&Japio | ||||||
| 237 | Automatic synthesis and purification of polynucleotide and equipment therefor | JP33246989 | 1989-12-21 | JPH0368593A | 1991-03-25 | UIRIAMU EE ANDORASU; KURISUTEII DEII MATSUKORAMU; JIERARUDO ZON |
| PURPOSE: To synthesize a polynucleotide automatically in a short time, by coupling a nucleoside 5'-blocked on a specific substrate, deblocking it to react a nucleoside-3'-amidite therewith, and cleaving it from the substrate. CONSTITUTION: This automatic synthesis of polynucleotide comprises after feeding a nucleoside having 3'- and 5'-hydroxy and 5'-blocked to a non-swellable polystyrene substrate so that a correct sequence is formed, deblocking the 5'- hydroxy, reacting a monomer such as a 5'-blocked and protected nucleoside-3'- amidite or a nucleoside-3'-hydrodine phosphonate with 5'-hydroxy of the correct sequence, repeating this operation until a polynucleotide having an expected sequence is obtained, and cleaving the obtd. polynucleotide from the substrate. COPYRIGHT: (C)1991,JPO | ||||||
| 238 | Bop reagent for synthesis of solid peptide | JP10891388 | 1988-04-30 | JPS6452795A | 1989-02-28 | DEREKU HADOSON |
| 239 | JPS63501591A - | JP50510286 | 1986-09-24 | JPS63501591A | 1988-06-16 | |
| 240 | JPS6256464B2 - | JP5256277 | 1977-05-07 | JPS6256464B2 | 1987-11-26 | UIRIAMU YAKOBU DOREIYAA |
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