| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 通过移行RNA干扰来降低或消除丝状真菌菌株中的基因表达的方法 | CN201510920723.8 | 2007-12-20 | CN105420268A | 2016-03-23 | 霍华德·布罗迪; 唐娜·莫耶; 阿曼达·费希尔 |
| 本发明涉及通过移行RNA干扰来降低或消除丝状真菌菌株中的基因表达的方法，具体地涉及通过移行RNA干扰来降低或消除丝状真菌菌株中的靶基因表达的方法。 | ||||||
| 2 | 通过移行RNA干扰来降低或消除丝状真菌菌株中的基因表达的方法 | CN200780051262.9 | 2007-12-20 | CN101652479A | 2010-02-17 | 霍华德·布罗迪; 唐娜·莫耶; 阿曼达·费希尔 |
| 本发明涉及通过移行RNA干扰来降低或消除丝状真菌菌株中的靶基因表达的方法。 | ||||||
| 3 | USE OF HETEROLOGOUS EXPRESSED POLYKETIDE SYNTHASE AND SMALL MOLECULE FOLDASES TO MAKE AROMATIC AND CYCLIC COMPOUNDS | US15735023 | 2016-06-10 | US20180305709A1 | 2018-10-25 | Rasmus John Normand FRANDSEN; Uffe Hasbro MORTENSEN; Hilde Cornelijne COUMOU; Rubini Maya KANNANGARA; Bjørn MADSEN; Majse NAFISI; Johan ANDERSEN-RANBERG; Kenneth Thermann KONGSTAD; Finn Thyge OKKELS; Paiman KHORSAND-JAMAL; Dan STÆRK; Birger Lindberg MØLLER |
| A method for producing individual or libraries of tri- to pentadecaketide-derived aromatic compounds of interest by heterologous expression of polyketide synthase and aromatase/cyclase in a recombinant host cell. | ||||||
| 4 | Methods for eliminating or reducing the expression of genes in filamentous fungal strains by transitive RNA interference | US15296489 | 2016-10-18 | US20170029821A1 | 2017-02-02 | Howard Brody; Donna Moyer; Amanda Fisher |
| The present invention relates to methods of reducing or eliminating expression of a target gene in a filamentous fungal strain by transitive RNA interference. | ||||||
| 5 | Molecules Associated with Fatty Acid Biosynthetic Pathways and Uses Thereof | US14637356 | 2015-03-03 | US20160122741A1 | 2016-05-05 | Gerardo V. Toledo; Karen D. Xu; Jun Urano |
| The present disclosure relates in part to recombinant microorganisms that include non-native genes encoding PUFA-PKS polypeptides, and to methods of making and using such microorganisms for producing at least one PUFA. In particular, the disclosure further relates to methods and related materials useful for the production of at least one PUFA by heterologous expression of the nucleic acid sequences disclosed herein encoding PUFA-PKS polypeptides. | ||||||
| 6 | Reduction or removal method of gene expression in filamentous strain due to secondary rna interference | JP2009543235 | 2007-12-20 | JP2010514419A | 2010-05-06 | フィッシャー，アマンダ; ブロディ，ハワード; モイヤー，ドナ |
| 本発明は、二次的ＲＮＡ干渉により糸状菌株において標的遺伝子の発現を低下又は除去する方法に関する。 | ||||||
| 7 | METHODS OF REDUCING OR ELIMINATING EXPRESSION OF GENES IN FILAMENTOUS FUNGAL STRAINS BY TRANSITIVE RNA INTERFERENCE | EP07865933.1 | 2007-12-20 | EP2097525B1 | 2013-06-19 | BRODY, Howard; MOYER, Donna; FISHER, Amanda |
| 8 | METHODS OF REDUCING OR ELIMINATING EXPRESSION OF GENES IN FILAMENTOUS FUNGAL STRAINS BY TRANSITIVE RNA INTERFERENCE | EP07865933.1 | 2007-12-20 | EP2097525A1 | 2009-09-09 | BRODY, Howard; MOYER, Donna; FISHER, Amanda |
| The present invention relates to methods of reducing or eliminating expression of a target gene in a filamentous fungal strain by transitive RNA interference. | ||||||
| 9 | USE OF HETEROLOGOUS EXPRESSED POLYKETIDE SYNTHASE AND SMALL MOLECULE FOLDASES TO MAKE AROMATIC AND CYCLIC COMPOUNDS | EP16732964.8 | 2016-06-10 | EP3307900A1 | 2018-04-18 | FRANDSEN, Rasmus John Normand; MORTENSEN, Uffe Hasbro; COUMOU, Hilde Cornelijne; KANNANGARA, Rubini Maya; MADSEN, Bjørn; NAFISI, Majse; ANDERSEN-RANBERG, Johan; KONGSTAD, Kenneth Thermann; OKKELS, Finn Thyge; KHORSAND-JAMAL, Paiman; STÆRK, Dan; MØLLER, Birger Lindberg |
| A method for producing individual or libraries of tri- to pentadecaketide-derived aromatic compounds of interest by heterologous expression of polyketide synthase and aromatase/cyclase in a recombinant host cell. | ||||||
| 10 | Molecules associated with fatty acid biosynthetic pathways and uses thereof | US14637356 | 2015-03-03 | US10131897B2 | 2018-11-20 | Gerardo V. Toledo; Karen D. Xu; Jun Urano |
| The present disclosure relates in part to recombinant microorganisms that include non-native genes encoding PUFA-PKS polypeptides, and to methods of making and using such microorganisms for producing at least one PUFA. In particular, the disclosure further relates to methods and related materials useful for the production of at least one PUFA by heterologous expression of the nucleic acid sequences disclosed herein encoding PUFA-PKS polypeptides. | ||||||
| 11 | Methods of eliminating or reducing expression of genes in filamentous fungal strains by transitive RNA interference | US12520067 | 2007-12-20 | US09499820B2 | 2016-11-22 | Howard Brody; Donna Moyer; Amanda Fisher |
| The present invention relates to methods of reducing or eliminating expression of a target gene in a filamentous fungal strain by transitive RNA interference. | ||||||
| 12 | Methods of Eliminating or Reducing Expression of Genes in Filamentous Fungal Strains by Transitive RNA Interference | US12520067 | 2007-12-20 | US20100055755A1 | 2010-03-04 | Howard Brody; Donna Moyer; Amanda Fisher |
| The present invention relates to methods of reducing or eliminating expression of a target gene in a filamentous fungal strain by transitive RNA interference. | ||||||
| 13 | 신규 타입 Ⅲ 폴리케타이드 합성효소 및 그 응용 | KR1020100050022 | 2010-05-28 | KR1020110130614A | 2011-12-06 | 이정걸; 휘민자오; 이정임; 이경미; 마리무투제야 |
| PURPOSE: A chalcone synthase is provided to produce a large amount of chalcone. CONSTITUTION: A type III polyketide synthase has an amino acid sequence of sequence number 4 or functional fragment thereof. The type III polyketide synthase is derived from Aspergillus flavus. A gene encoding the type III polyketide synthase has a base sequence of sequence number 3. The Aspergillus flavus is denoted as KACC93105P. A composition for manufacturing chalcone contains the type III polyketide synthase. A method for producing chalcone comprises a step of reacting the type III polyketide synthase with a substrate of 4-coumaroyl CoA, malonyl CoA, caffeoyl CoA, cinnaoyl CoA, or benzoyl CoA. | ||||||
| 14 | HYBRID POLYKETIDE SYNTHASES | PCT/US2011058660 | 2011-10-31 | WO2012058686A2 | 2012-05-03 | FORTMAN JEFFREY L; HAGEN ANDREW; KATZ LEONARD; KEASLING JAY; POUST SEAN; ZHANG JINGWEI; ZOTCHEV SERGEY |
| The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin. | ||||||
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