| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 酰基-酰基载体蛋白(ACYL-ACP)蜡酯合酶 | CN201280057444.8 | 2012-03-06 | CN103975070A | 2014-08-06 | 埃里克·霍尔特萨普尔; 约翰·H·韦鲁托 |
| 本发明涉及在经改造以表达酰基-ACP蜡酯合酶和形成醇的酰基-ACP还原酶的重组宿主细胞中产生蜡酯的非酰基-CoA依赖性方法。本发明方法可在光合微生物中且特别是在蓝细菌中进行。还提供表达酰基-ACP蜡酯合酶和/或形成醇的酰基-ACP还原酶的分离核苷酸分子和载体，表达酰基-ACP蜡酯合酶和任选地形成醇的酰基-ACP还原酶的重组宿主细胞，以及用于通过非酰基-CoA依赖性路径产生蜡酯的系统。 | ||||||
| 2 | 基因及用途、基因元件、合成奇数中链脂肪醛的方法以及合成偶数中链脂肪烃的方法 | CN201410566258.8 | 2014-10-22 | CN105586350A | 2016-05-18 | 元英进; 曹英秀; 刘夺; 丁明珠; 谢泽雄; 张金来 |
| 本发明涉及生物技术领域，特别涉及基因及用途、基因元件、合成奇数中链脂肪醛的方法以及合成偶数中链脂肪烃的方法。α-加双氧酶将前体物脂肪酸分子转化为重要中间代谢物——脂肪醛的过程为氧化反应，不需要细胞提供额外的还原力和能量，降低了细胞生产的负担；填补了脂肪醇产物链长仅为偶数，脂肪烃产物链长大多为奇数的技术局限，可以使生物基大宗化学品以及生物燃料的分子与石油基相关产品更为匹配。 | ||||||
| 3 | 产生碳氢化合物的方法和组合物 | CN200980117663.9 | 2009-05-18 | CN102027108A | 2011-04-20 | 安德里亚斯·席尔默; 马修·路德; 谢恩·布鲁贝克 |
| 本为描述了用于产生诸如醛、烷和烯的碳氢化合物的组合物和方法。某些碳氢化合物可用于生物燃料。 | ||||||
| 4 | Methods and compositions for the production of hydrocarbons | JP2011509795 | 2009-05-18 | JP2011522525A | 2011-08-04 | アンドレアス・シルマー; シェイン・ブルベイカー; マシュー・ルード |
| 本願明細書にて、アルデヒド、アルカンおよびアルケンを製造するための組成物および方法が記載される。 該アルデヒド、アルカンおよびアルケンは、バイオ燃料にて使用され得る。 | ||||||
| 5 | Methods and compositions for the production of hydrocarbons | JP2011509796 | 2009-05-18 | JP2011520455A | 2011-07-21 | アンドレアス・シルマー; シェイン・ブルベイカー; マシュー・ルード |
| 本願明細書にて、アルデヒド、アルカンおよびアルケンといった炭化水素を製造するための組成物および方法が記載される。 いくつかの炭化水素はバイオ燃料にて使用され得る。 | ||||||
| 6 | METHODS AND COMPOSITIONS FOR PRODUCING FATTY ALCOHOLS AND FATTY ALDEHYDES | US15592772 | 2017-05-11 | US20180080053A1 | 2018-03-22 | Andreas W. Schirmer; Mathew A. Rude; Shane Brubaker |
| Compositions and methods for producing hydrocarbons such as aldehydes, alkanes, and alkenes are described herein. Certain hydrocarbons can be used in biofuels. | ||||||
| 7 | COMPOSTITIONS AND METHODS FOR RECOMBINANT BIOSYNTHESIS OF PROPANE | US15421861 | 2017-02-01 | US20170218401A1 | 2017-08-03 | Nigel Scrutton; Patrik Jones; Navya Menon |
| Provided are genetically engineered microorganism that catalyze the synthesis of propane and/or butanol from a suitable substrate such as glucose. Also provided are methods of engineering said genetically engineered microorganism and methods of producing propane and/or butanol using the genetically engineered microorganism. | ||||||
| 8 | Recombinant synthesis of medium chain-length alkanes | US14682354 | 2015-04-09 | US09528127B2 | 2016-12-27 | Frank Anthony Skraly; Ning Li |
| The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently produce alkanes, and in particular the use of such organisms for the commercial production of alkanes and related molecules. Other materials, methods, and compositions are also described. | ||||||
| 9 | METHOD FOR PREPARING A HYDROCARBON | US14208857 | 2014-03-13 | US20140193873A1 | 2014-07-10 | Thomas Paul HOWARD; Sabine MIDDELHAUFE; Dagmara KOLAK; Stephen J. AVES; John LOVE; David PARKER; George Robert LEE |
| A method for preparing a hydrocarbon comprising contacting a fatty acid substrate with at least one fatty acid reductase and at least one fatty aldehyde synthetase and at least one fatty acyl transferase, wherein the fatty acid substrate is a fatty acid, a fatty acyl-ACP, or a fatty acyl-CoA or a mixture of any of these, to obtain a fatty aldehyde; and contacting the fatty aldehyde with at least one aldehyde decarbonylase enzyme. | ||||||
| 10 | METHODS AND COMPOSITIONS FOR PRODUCING HYDROCARBONS | US13625107 | 2012-09-24 | US20130029395A1 | 2013-01-31 | Andreas W. SCHIRMER; Mathew A. Rude; Shane A. Brubaker |
| Compositions and methods for producing aldehydes, alkanes, and alkenes are described herein. The aldehydes, alkanes, and alkenes can be used in biofuels. | ||||||
| 11 | METHODS AND COMPOSITIONS FOR PRODUCING FATTY ALCOHOLS AND FATTY ALDEHYDES | US13552522 | 2012-07-18 | US20120282663A1 | 2012-11-08 | Andreas Schirmer; Mathew Rude; Shane Brubaker |
| Compositions and methods for producing hydrocarbons such as aldehydes, alkanes, and alkenes are described herein. Certain hydrocarbons can be used in biofuels. | ||||||
| 12 | Methods and compositions for producing hydrocarbons | US15284727 | 2016-10-04 | US10150975B2 | 2018-12-11 | Andreas W. Schirmer; Mathew A. Rude; Shane A. Brubaker |
| Compositions and methods for producing aldehydes, alkanes, and alkenes are described herein. The aldehydes, alkanes, and alkenes can be used in biofuels. | ||||||
| 13 | GENES AND USES THEREOF, METHODS FOR SYNTHESIZING ODD NUMBERED MEDIUM CHAIN ALIPHATIC ALDEHYDES AND METHODS FOR SYNTHESIZING EVEN NUMBERED MEDIUM CHAIN ALIPHATIC HYDROCARBONS | US15516480 | 2015-09-09 | US20180273918A1 | 2018-09-27 | Yingjin Yuan; Yingxiu CAO; Wenhai XIAO; Duo Liu; Mingzhu DING; Zexiong XIE; Jinlai ZHANG |
| Provided are genes, coding proteins and uses thereof, gene elements, genes and uses, gene elements, methods for synthesizing odd numbered medium chain aliphatic aldehydes, for synthesizing odd numbered medium chain aliphatic alcohol and for synthesizing even numbered medium chain aliphatic hydrocarbons. Provided is method for producing odd numbered aliphatic alcohols in Escherichia coli. An α-dioxygenase from rice is used without additional deoxidization and energy supply from cells. The α-dioxygenase can also be used for synthesizing aliphatic alcohols with different proportions of C11 to C15 by co-working with different thioesterases. | ||||||
| 14 | METHODS AND COMPOSITIONS FOR PRODUCING FATTY ALCOHOLS OR FATTY ALDEHYDES | US14061512 | 2013-10-23 | US20150315617A1 | 2015-11-05 | ANDREAS W. SCHIRMER; MATHEW A. RUDE; SHANE BRUBAKER |
| Compositions and methods for producing hydrocarbons such as aldehydes, alkanes, and alkenes are described herein. Certain hydrocarbons can be used in biofuels. | ||||||
| 15 | Methods and compositions for producing fatty alcohols and fatty aldehydes | US13552522 | 2012-07-18 | US08658404B2 | 2014-02-25 | Andreas W. Schirmer; Mathew A. Rude; Shane A. Brubaker |
| Compositions and methods for producing hydrocarbons such as aldehydes, alkanes, and alkenes are described herein. Certain hydrocarbons can be used in biofuels. | ||||||
| 16 | METHOD FOR PREPARING A HYDROCARBON | US13774647 | 2013-02-22 | US20130224818A1 | 2013-08-29 | Thomas Paul HOWARD; Sabine MIDDELHAUFE; Dagmara KOLAK; Stephen J. AVES; John LOVE; David PARKER; George Robert LEE |
| A method for preparing a hydrocarbon comprising contacting a fatty acid substrate with at least one fatty acid reductase and at least one fatty aldehyde synthetase and at least one fatty acyl transferase, wherein the fatty acid substrate is a fatty acid, a fatty acyl-ACP, or a fatty acyl-CoA or a mixture of any of these, to obtain a fatty aldehyde; and contacting the fatty aldehyde with at least one aldehyde decarbonylase enzyme. | ||||||
| 17 | ACYL-ACP WAX ESTER SYNTHASES | US13413426 | 2012-03-06 | US20130078684A1 | 2013-03-28 | Erik Holtzapple; John H. Verruto |
| The invention relates to acyl-CoA-independent methods of producing a wax ester in recombinant host cells engineered to express an acyl-ACP wax ester synthase, and an alcohol-forming acyl-ACP reductase. The methods of the invention may take place in photosynthetic microorganisms, and particularly in cyanobacteria. Isolated nucleotide molecules and vectors expressing an acyl-ACP wax ester synthase and/or an alcohol-forming acyl-ACP reductase, recombinant host cells expressing an acyl-ACP wax ester synthase and optionally an alcohol-forming acyl-ACP reductase, and systems for producing a wax ester via an acyl-CoA-independent pathway, are also provided. | ||||||
| 18 | Method for producing a fatty alcohol or fatty aldehyde | US12710238 | 2010-02-22 | US08268599B2 | 2012-09-18 | Andreas Schirmer; Mathew Rude; Shane Brubaker |
| Compositions and methods for producing hydrocarbons such as aldehydes, alkanes, and alkenes are described herein. Certain hydrocarbons can be used in biofuels. | ||||||
| 19 | METHODS AND COMPOSITIONS FOR PRODUCING HYDROCARBONS | EP09747776.4 | 2009-05-18 | EP2288694B1 | 2018-03-07 | SCHIRMER, Andreas; RUDE, Mathew; BRUBAKER, Shane |
| Compositions and methods for producing hydrocarbons such as aldehydes, alkanes, and alkenes are described herein. Certain hydrocarbons can be used in biofuels. | ||||||
| 20 | TYPE II FATTY ACID SYSTHESIS ENZYMES IN REVERSE B-OXIDATION | EP15740946 | 2015-01-26 | EP3099763A4 | 2017-08-02 | GONZALEZ RAMON; CLOMBURG JAMES M; VICK JACOB E |
| This disclosure describes enzymes from the type II (a discrete set of enzymes) fatty acid synthesis (“FAS”) pathway that can be used in combination with thiolases to operate a functional reversal of the β-oxidation cycle. A combination of thiolases with one or more of 3-oxoacyl-[acyl-carrier-protein] reductase (FabG, others), 3-hydroxyacyl-[acp] dehydratase (FabA, FabZ, others), and enoyl-[acyl-carrier-protein] reductase (FabI, FabK, FabL, FabV, others) yields a functional reversal of the β-oxidation cycle. If only one or two enzymes are used, the remaining enzymes will be traditional beta oxidation enzymes. Once this cycle is coupled with the appropriate priming and termination pathways, the production of carboxylic acids, alcohols, hydrocarbons, amines and their α-, β-, and ω-functionalized derivatives from renewable carbon sources can be achieved. | ||||||
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