| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | Method of RNA cleavage and recombination | US10821777 | 2004-04-09 | US20050043259A1 | 2005-02-24 | Glauco Tocchini-Valentini; Giancarlo Deidda; Nicoletta Rossi |
| A method of cleaving a target RNA molecule is disclosed. In one embodiment the method comprises the step of exposing the target molecule to an eukaryotic tRNA splicing endonuclease, wherein the target molecule is in the bulge-helix-bulge conformation, wherein cleavage occurs within the bulge-helix-bulge and cleavage products are generated, and wherein the target molecule does not comprise a tRNA structure. | ||||||
| 2 | Method of RNA cleavage and recombination | US10821777 | 2004-04-09 | US08512945B2 | 2013-08-20 | Glauco P. Tocchini-Valentini; Giancarlo Deidda; Nicoletta Rossi |
| A method of cleaving a target RNA molecule is disclosed. In one embodiment the method comprises the step of exposing the target molecule to an eukaryotic tRNA splicing endonuclease, wherein the target molecule is in the bulge-helix-bulge conformation, wherein cleavage occurs within the bulge-helix-bulge and cleavage products are generated, and wherein the target molecule does not comprise a tRNA structure. | ||||||
| 3 | Modification of protein by use of a controllable interveining protein sequence | US4139 | 1992-12-09 | US5496714A | 1996-03-05 | Donald G. Comb; Francine B. Perler; William E. Jack; Ming-Qun Xu; Robert A. Hodges |
| The present invention is directed to modified proteins and methods of their production. The modified proteins comprise a controllable intervening protein sequence (CIVPS) inserted into a target protein, the CIVPS being capable of excision from the modified protein under predetermined conditions, i.e., increase in temperature, exposure to light, unblocking of amino acid residues by dephosphorylation or deglycosylation. If desired, the modified protein can be subjected to these conditions. The CIVPS may also be inserted into a region that substantially inactivates target protein activity. | ||||||
| 4 | METHOD OF RNA CLEAVAGE AND RECOMBINATION | PCT/EP2004003915 | 2004-04-14 | WO2004090133A3 | 2004-11-18 | TOCCHINI-VALENTINI GLAUCO P; DEIDDA GIANCARLO; ROSSI NICOLETTA |
| A method of cleaving a target RNA molecule is disclosed. In one embodiment the method comprises the step of exposing the target molecule to an eukaryotic tRNA splicing endonuclease, wherein the target molecule is in the bulge-helix-bulge conformation, wherein cleavage occurs within the bulge-helix-bulge and cleavage products are generated, and wherein the target molecule does not comprise a tRNA structure. | ||||||
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