| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 杂交种子生产 | CN99805258.2 | 1999-01-22 | CN1298450A | 2001-06-06 | M·E·奈特; I·杰普森; A·达利; M·W·贝利斯 |
| 披露了制备杂交种子的方法,上述方法包括将雄性可育并且纯合隐性雌性不育的父本植株和纯合隐性雄性不育和雌性可育的母本植株相间种植在一起,进行异花授粉,并获得由此所产生的种子。每一种亲本植株的基因组材料上还可以整合一种基因结构,该结构包括对一种外源化学诱导物的存在或缺乏有反应的启动子序列,并可任选有效连接于一个或几个增强子或内含子序列上,有效连接于能完全恢复每一种亲本植株的育性的基因上,所述基因是通过在所述植株上使用一种外源化学诱导物,以便使得每一种亲本异花授粉而得到表达。 | ||||||
| 2 | 杂交种子生产 | CN99805258.2 | 1999-01-22 | CN1206360C | 2005-06-15 | M·E·奈特; I·杰普森; A·达利; M·W·贝利斯 |
| 披露了制备杂交种子的方法，上述方法包括将雄性可育并且纯合隐性雌性不育的父本植株和纯合隐性雄性不育和雌性可育的母本植株相间种植在一起，进行异花授粉，并获得由此所产生的种子。每一种亲本植株的基因组材料上还可以整合一种基因结构，该结构包括对一种外源化学诱导物的存在或缺乏有反应的启动子序列，并可任选有效连接于一个或几个增强子或内含子序列上，有效连接于能完全恢复每一种亲本植株的育性的基因上，所述基因是通过在所述植株上使用一种外源化学诱导物，以便使得每一种亲本异花授粉而得到表达。 | ||||||
| 3 | Plants with modified stamen cells | US08485516 | 1995-06-07 | US06627799B1 | 2003-09-30 | Celestina Mariani; Jan Leemans; Willy De Greef; Marc De Beuckeleer |
| A plant, the nuclear genome of which is transformed with a foreign DNA sequence encoding a product which selectively disrupts the metabolism, functioning and/or development of stamen cells of the plant. The foreign DNA sequence also optionally encodes a marker. | ||||||
| 4 | Plants with modified stamen cells | US08027580 | 1993-03-05 | US06372967B1 | 2002-04-16 | Celestina Mariani; Jan Leemans; Willy De Greef; Marc De Beuckeleer |
| A plant, the nuclear genome of which is transformed with a foreign DNA sequence encoding a protein or polypeptide which disrupts the metabolism, functioning and/or development of stamen cells of the plant, said foreign DNA under the control of a stamen-specific promoter. The foreign DNA sequence also optionally encodes a marker. | ||||||
| 5 | SWITCHABLE NON-scFv CHIMERIC RECEPTORS, SWITCHES, AND USES THEREOF | US15561274 | 2016-03-28 | US20180118808A1 | 2018-05-03 | Travis YOUNG; Chanhyuk KIM; Peter G. SCHULTZ |
| Disclosed herein are switchable chimeric receptors, switchable chimeric receptor effector cells and chimeric receptor effector cell switches. The switchable chimeric receptor-ECs are generally T cells. The chimeric receptors have non-antibody extracellular domains that recognize a chimeric receptor binding partner on the chimeric receptor-EC switch or target cell. The chimeric receptor-ECs and switches may be used for the treatment of a disease or condition in a subject in need thereof. | ||||||
| 6 | Hybrid seed production | US09601812 | 2000-09-18 | US06683230B1 | 2004-01-27 | Ian Jepson; Allan Daly; Mary Elizabeth Knight; Michael William Bayliss |
| Methods of preparing hybrid seed are described. One such method comprises interplanting a male parent plant which is male fertile and homozygous recessive female sterile and a female parent plant which is homozygous recessive male sterile and female fertile, allowing cross-pollination and obtaining the seed produced therefrom. The genomic material of each parent plant may also have integrated therein a gene construct comprising a promoter sequence-responsive to the presence or absence of an exogenous chemical inducer, optionally operably linked to one or more enhancer or intron sequences, operably linked to a gene which fully restores the fertility of each parent plant, the gene being expressed by the application to the plant of an external chemical inducer thereby allowing each parent to self-pollinate. | ||||||
| 7 | Plants with modified stamen cells | US08485511 | 1995-06-07 | US06344598B1 | 2002-02-05 | Celestina Mariani; Jan Leemans; Willy De Greef; Marc De Beuckeleer |
| A plant, the nuclear genome of which is transformed with a foreign DNA sequence encoding a protein or polypeptide which disrupts the metabolism, functioning and/or development of stamen cells of the plant, said foreign DNA under the control of a stamen-specific promoter. The foreign DNA sequence also optionally encodes a marker. | ||||||
| 8 | Plants with modified stamen cells | US08485788 | 1995-06-07 | US06320097B1 | 2001-11-20 | Celestina Mariani; Jan Leemans; Willy De Greef; Marc De Beuckeleer |
| A plant, the nuclear genome of which is transformed with a foreign DNA sequence encoding a product which selectively disrupts the metabolism, functioning and/or development of stamen cells of the plant. The foreign DNA sequence also optionally encodes a marker. | ||||||
| 9 | Plants with modified stamen cells | US08485793 | 1995-06-07 | US06316699B1 | 2001-11-13 | Celestina Mariani; Jan Leemans; Willy De Greef; Marc De Beuckeleer |
| A plant, the nuclear genome of which is transformed with a foreign DNA sequence encoding a product which selectively disrupts the metabolism, functioning and/or development of stamen cells of the plant. The foreign DNA sequence also optionally encodes a marker. | ||||||
| 10 | Stamen-selective promoters | US485792 | 1995-06-07 | US5652354A | 1997-07-29 | Celestina Mariani; Jan Leemans; Willy De Greef; Marc De Beuckeleer |
| Promoters from endogenous genes of plants are isolated, wherein said promoters direct gene expression selectively in stamen cells of said plant, particularly in tapetum cells of said plant. The promoters may be used to transform a plant with a foreign DNA sequence encoding a product which selectively disrupts the metabolism, functioning, and/or development of stamen cells of the plant. | ||||||
| 11 | Therapeutic agent for malignant tumor | JP2009033373 | 2009-02-17 | JP2012092019A | 2012-05-17 | IGUCHI NORIO; SUZUKI TAKASHI; KOBAYASHI HIROKO; TABATA KEIICHI |
| PROBLEM TO BE SOLVED: To provide a new therapeutic agent for a malignant tumor.SOLUTION: The therapeutic agent for a malignant tumor contains a T1-type ribonuclease derived from an oyster mushroom. | ||||||
| 12 | Plants with modified stamen cells | JP20691299 | 1999-07-21 | JP3727492B2 | 2005-12-14 | ウイリー・デ・グレーフ; ジヤン・レーマンス; セレステイナ・マリアニ; マルク・デ・ブツケレール |
| A plant, the nuclear genome of which is transformed with a foreign DNA sequence encoding a product which selectively disrupts the metabolism, functioning and/or development of stamen cells of the plant. The foreign DNA sequence also optionally encodes a marker. | ||||||
| 13 | JPH02503988A - | JP50451489 | 1989-04-27 | JPH02503988A | 1990-11-22 | |
| 14 | Of hybrid seed production | JP2000532538 | 1999-01-22 | JP2002504343A | 2002-02-12 | イーアン ジェプソン，; アラン ダリー，; メアリー エリザベス ナイト，; マイケル ウイリアム ベイリス， |
| (57)【要約】 ハイブリッド種子を調製する方法が記載される。 このような１つの方法は、雄性稔性およびホモ接合性劣性雌性不稔である雄性親植物、ならびにホモ接合性劣性雄性不稔および雌性稔性である雌性親植物とを間植する工程、他家受粉させる工程、およびそれから生産される種子を得る工程を包含する。 各親植物の遺伝物質はまた、必要に応じて１つ以上のエンハンサー配列またはイントロン配列に作動可能に連結され、各親植物の稔性を十分に回復する遺伝子に作動可能に連結される外因性化学誘導因子の存在または非存在に対して応答するプロモーター配列を含む、遺伝子構築物がまた各親植物に組込まれ得、この遺伝子が、外部の化学誘導因子の上記植物への適用によって発現され、それによって各親の自家受粉を可能にする。 | ||||||
| 15 | Plants with modified stamen cells | JP50451489 | 1989-04-27 | JP3020530B2 | 2000-03-15 | デ・グレーフ，ウイリー; デ・ブツケレール，マルク; マリアニ，セレステイナ; レーマンス，ジヤン |
| 16 | Plant having modified stamen cell | JP20691299 | 1999-07-21 | JP2000037146A | 2000-02-08 | MARIANI CELESTINA; LEEMANS JAN; GREEF WILLY DE; BEUCKELEER MARC DE |
| PROBLEM TO BE SOLVED: To obtain a male sterility plant having excellent disease resistance and environmental suitability, useful for producing a hybrid seed by including a specific adventitious DNA in the whole cell nuclear genome. SOLUTION: This male sterility plant has an adventitious DNA in the whole cell nuclear genome. The adventitious DNA is (i) a male sterility DNA capable of perishing or paralyzing a stamen cell and preventing the production of a fertile male gamete when expressed in the stamen cell of the male sterility plant (e.g. potato or the like) and contains (ii) a first promoter such as TA29 gene promoter or the like selectively inducing gene expression in the stamen cell of the plant in which the male sterility DNA exists in the same transcriptional unit of the first promoter and is under the control of the unit with the proviso that in the case of the first promoter being a promoter for selectively expressing the male sterility DNA in a microspore and/or a pollen cell, a plant cell nuclear genome is a homozygote. The plant can be transformed with Agrobacterium. | ||||||
| 17 | Hybrid seed production | EP10178609.3 | 1999-01-22 | EP2258856A1 | 2010-12-08 | Bayliss, Michael; Daly, Allan; Jepson, Ian; Knight, Mary |
Methods of preparing hybrid seed are described. One such method comprises interplanting a male parent plant which is male fertile and homozygous recessive female sterile and a female parent plant which is homozygous recessive male sterile and female fertile, allowing cross-pollination and obtaining the seed produced therefrom. The genomic material of each parent plant may also have integrated therein a gene construct comprising a promoter sequence responsive to the presence or absence of an exogenous chemical inducer, optionally operably linked to one or more enhancer or intron sequences, operably linked to a gene which fully restores the fertility of each parent plant, the gene being expressed by the application to the plant of an external chemical inducer thereby allowing each parent to self-pollinate. |
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| 18 | HYBRID SEED PRODUCTION | EP99901793.2 | 1999-01-22 | EP1054985A2 | 2000-11-29 | KNIGHT, Mary Elizabeth; JEPSON, Ian; DALY, Allan; BAYLISS, Michael William |
| Methods of preparing hybrid seed are described. One such method comprises interplanting a male parent plant which is male fertile and homozygous recessive female sterile and a female parent plant which is homozygous recessive male sterile and female fertile, allowing cross-pollination and obtaining the seed produced therefrom. The genomic material of each parent plant may also have integrated therein a gene construct comprising a promoter sequence responsive to the presence or absence of an exogenous chemical inducer, optionally operably linked to one or more enhancer or intron sequences, operably linked to a gene which fully restores the fertility of each parent plant, the gene being expressed by the application to the plant of an external chemical inducer thereby allowing each parent to self-pollinate. | ||||||
| 19 | Plants with modified stamen cells | EP96107004.2 | 1989-04-26 | EP0737749A1 | 1996-10-16 | Mariani, Celestina; Leemans, Jan; De Greef, Willy; De Beuckeleer, Marc |
A plant, the nuclear genome of which is transformed with a foreign DNA sequence encoding a product which selectively disrupts the metabolism, functioning and/or development of stamen cells of the plant. The foreign DNA sequence also optionally encodes a marker. |
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| 20 | HYBRID SEED PRODUCTION | EP99901793.2 | 1999-01-22 | EP1054985B1 | 2012-04-18 | KNIGHT, Mary Elizabeth; JEPSON, Ian; DALY, Allan; BAYLISS, Michael William |
| Methods of preparing hybrid seed are described. One such method comprises interplanting a male parent plant which is male fertile and homozygous recessive female sterile and a female parent plant which is homozygous recessive male sterile and female fertile, allowing cross-pollination and obtaining the seed produced therefrom. The genomic material of each parent plant may also have integrated therein a gene construct comprising a promoter sequence responsive to the presence or absence of an exogenous chemical inducer, optionally operably linked to one or more enhancer or intron sequences, operably linked to a gene which fully restores the fertility of each parent plant, the gene being expressed by the application to the plant of an external chemical inducer thereby allowing each parent to self-pollinate. | ||||||
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