| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | TREATMENT OF DISEASES ASSSOCIATED WITH FAT ACCUMULATION | US15532827 | 2015-12-03 | US20170326208A1 | 2017-11-16 | Padraic FALLON; Emily HAMS |
| The present invention is directed to immunmodulators in the form of compositions, compounds, proteins and/or fragments with RNase activity thereof for use in the treatment of diseases associated with fat accumulation, including obesity and obesity-related disorders and metabolic disorders. | ||||||
| 2 | METHODS OF AND COMPOSITIONS FOR INHIBITING THE PROLIFERATION OF MAMMALIAN CELLS | US12890762 | 2010-09-27 | US20110008314A1 | 2011-01-13 | Levava Roiz; Betty Schwartz; Patricia Smirnoff; Oded Shoseyov |
| A method of preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The method is effected by administering to the subject a therapeutically effective amount of a ribonuclease of the T2 family having actin binding activity. | ||||||
| 3 | Methods of and compositions for inhibiting the proliferation of mammalian cells | US14020927 | 2013-09-09 | US08735127B2 | 2014-05-27 | Levava Roiz; Betty Schwartz; Patricia Smirnoff; Oded Shoseyov |
| A method of preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The method is effected by administering to the subject a therapeutically effective amount of a ribonuclease of the T2 family having actin binding activity. | ||||||
| 4 | Methods of and compositions for inhibiting the proliferation of mammalian cells | US12890762 | 2010-09-27 | US08236543B2 | 2012-08-07 | Levava Roiz; Betty Schwartz; Patricia Smirnoff; Oded Shoseyov |
| A method of preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The method is effected by administering to the subject a therapeutically effective amount of a ribonuclease of the T2 family having actin binding activity. | ||||||
| 5 | METHODS OF AND COMPOSITIONS FOR INHIBITING THE PROLIFERATION OF MAMMALIAN CELLS | US13342067 | 2012-01-01 | US20120100128A1 | 2012-04-26 | Levava Roiz; Betty Schwartz; Patricia Smirnoff; Oded Shoseyov |
| A method of preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The method is effected by administering to the subject a therapeutically effective amount of a ribonuclease of the T2 family having actin binding activity. | ||||||
| 6 | Methods and compositions for inhibiting the growth of mammalian cells | JP2001519760 | 2000-08-29 | JP2003508411A | 2003-03-04 | ベティ シュワルツ，; オデッド ショセヨヴ，; パトリシア スミルノフ，; レヴァヴァ ロイズ， |
| (57)【要約】 被験者の異常に増殖する細胞の増殖、定着、分化および／または発育を予防し、阻害しおよび／または逆転する方法を開示する。 その方法は、被験者に、治療のために有効な量のＴ２ファミリーのリボヌクレアーゼを投与することによって行われる。 | ||||||
| 7 | Use of a ribonuclease of the T2 family having actin-binding activity for inhibiting tumor angiogenesis | EP10183935.5 | 2000-08-29 | EP2294918B8 | 2012-11-14 | Roiz, Levava; Shoseyov, Oded; Schwartz, Betty; Smirnoff, Patricia |
| The present invention concerns the use of a ribonuclease of the T2 family for the preparation of a medicament for preventing, inhibiting and/or reversing proliferation, colonization, differentiation and/or development of abnormally proliferating cells in a subject, wherein the RNAse T2 has the following characteristics: (i) 5 cysteine-cysteine disulphide bonds; (ii) a molecular weight of between 24-36 kDa; (iii) binds actin in either its active or non-active ribonucleolytic form; and (iv) in the ribonucleolytic form has an optimum temperature range of 50-60 °C and a pH optimum in the acidic range of between 3.5-5. | ||||||
| 8 | METHODS OF AND COMPOSITIONS FOR INHIBITING THE PROLIFERATION OF MAMMALIAN CELLS | EP00954879.3 | 2000-08-29 | EP1207755A1 | 2002-05-29 | ROIZ, Levava; SCHWARTZ, Betty; SMIRNOFF, Patricia; SHOSEYOV, Oded |
| The present invention concerns the use of a ribonuclease of the T2 family for the preparation of a medicament for preventing, inhibiting and/or reversing proliferation, colonization, differentiation and/or development of abnormally proliferating cells in a subject, wherein the RNAse T2 has the following characteristics: (i) 5 cysteine-cysteine disulphide bonds; (ii) a molecular weight of between 24-36 kDa; (iii) binds actin in either its active or non-active ribonucleolytic form; and (iv) in the ribonucleolytic form has an optimum temperature range of 50-60 °C and a pH optimum in the acidic range of between 3.5-5. | ||||||
| 9 | ACTIN BINDING PEPTIDES AND COMPOSITIONS COMPRISING SAME FOR INHIBITING ANGIOGENESIS AND TREATING MEDICAL CONDITIONS ASSOCIATED WITH SAME | US15113187 | 2015-01-29 | US20160340659A1 | 2016-11-24 | Oded SHOSEYOV; Betty SCHWARTZ; Shani DORON; Liron NESIEL; Assaf FRIEDLER; Hadar AMARTELY; Levava ROIZ; Patricia SMIRNOFF; Iris LEWIN |
| The present invention, in some embodiments thereof, relates to biologically active peptides and, more particularly, but not exclusively, to peptides from T2 RNase (RNASET2) having actin binding, pharmaceutical compositions comprising the same, therapeutic use thereof and methods for their production. | ||||||
| 10 | METHODS OF AND COMPOSITIONS FOR INHIBITING THE PROLIFERATION OF MAMMALIAN CELLS | US14020927 | 2013-09-09 | US20140011729A1 | 2014-01-09 | Levava ROIZ; Betty Schwartz; Patricia Smirnoff; Oded Shoseyov |
| A method of preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The method is effected by administering to the subject a therapeutically effective amount of a ribonuclease of the T2 family having actin binding activity. | ||||||
| 11 | Methods of and compositions for inhibiting the proliferation of mammalian cells | US13342067 | 2012-01-01 | US08617867B2 | 2013-12-31 | Levava Roiz; Betty Schwartz; Patricia Smirnoff; Oded Shoseyov |
| A method of preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The method is effected by administering to the subject a therapeutically effective amount of a ribonuclease of the T2 family having actin binding activity. | ||||||
| 12 | Methods of and compositions for inhibiting the proliferation of mammalian cells | US10952495 | 2004-09-29 | US07811981B2 | 2010-10-12 | Levava Roiz; Betty Schwartz; Patricia Smirnoff; Oded Shoseyov |
| A method of preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The method is effected by administering to the subject a therapeutically effective amount of a ribonuclease of the T2 family having actin binding activity. | ||||||
| 13 | Methods of and compositions for inhibiting the proliferation of mammalian cells | US10952495 | 2004-09-29 | US20050113327A1 | 2005-05-26 | Levava Roiz; Betty Schwartz; Patricia Smirnoff; Oded Shoseyov |
| A method of preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The method is effected by administering to the subject a therapeutically effective amount of a ribonuclease of the T2 family having actin binding activity. | ||||||
| 14 | Methods and compositions for inhibiting the growth of mammalian cells | JP2011149849 | 2011-07-06 | JP5467076B2 | 2014-04-09 | レヴァヴァ ロイズ，; ベティ シュワルツ，; パトリシア スミルノフ，; オデッド ショセヨヴ， |
| The present invention concerns the use of a ribonuclease of the T2 family for the preparation of a medicament for preventing, inhibiting and/or reversing proliferation, colonization, differentiation and/or development of abnormally proliferating cells in a subject, wherein the RNAse T2 has the following characteristics: (i) 5 cysteine-cysteine disulphide bonds; (ii) a molecular weight of between 24-36 kDa; (iii) binds actin in either its active or non-active ribonucleolytic form; and (iv) in the ribonucleolytic form has an optimum temperature range of 50-60 °C and a pH optimum in the acidic range of between 3.5-5. | ||||||
| 15 | Method of and composition for inhibiting proliferation of mammalian cells | JP2011149849 | 2011-07-06 | JP2011251971A | 2011-12-15 | ROIZ LEVAVA; SCHWARTZ BETTY; SMIRNOFF PATRICIA; SHOSEYOV ODED |
| PROBLEM TO BE SOLVED: To provide a method of preventing, inhibiting and/or reversing proliferation, colonization, differentiation and/or development of abnormally proliferating cells in a subject.SOLUTION: There is provided a method comprising a step of administering a therapeutically effective amount of a ribonuclease of the T2 family to a subject. The ribonuclease has avidity of actin and a molecular weight of between 24-36 kDa. Inactivating the ribonucleolytic activity is desirable by a process selected from the group consisting of boiling, autoclaving and chemically denaturing. In addition, the ribonuclease is preferred by an administration mode selected from the group consisting of oral administration, topical administration, tansmucosal administration, parenteral administration, rectal administration and by inhalation. | ||||||
| 16 | Methods and compositions for inhibiting the growth of mammalian cells | JP2001519760 | 2000-08-29 | JP4808346B2 | 2011-11-02 | ベティ シュワルツ，; オデッド ショセヨヴ，; パトリシア スミルノフ，; レヴァヴァ ロイズ， |
| The present invention concerns the use of a ribonuclease of the T2 family for the preparation of a medicament for preventing, inhibiting and/or reversing proliferation, colonization, differentiation and/or development of abnormally proliferating cells in a subject, wherein the RNAse T2 has the following characteristics: (i) 5 cysteine-cysteine disulphide bonds; (ii) a molecular weight of between 24-36 kDa; (iii) binds actin in either its active or non-active ribonucleolytic form; and (iv) in the ribonucleolytic form has an optimum temperature range of 50-60 °C and a pH optimum in the acidic range of between 3.5-5. | ||||||
| 17 | 활성형 재조합 리보뉴클레아제 2의 제조 방법 및 그 제조방법에 의한 단백질 | KR1020170033670 | 2017-03-17 | KR1020180107365A | 2018-10-02 | 구본훈; 구민규 |
| 본발명은 a)코돈최적화된리보뉴클레아제(ribonuclease) 2 유전자를주형으로하여서프라이머를이용하여 PCR로증폭시킨후, 벡터에클로닝하여발현벡터를제작하고, 이발현벡터를대장균에형질전환시킨후, 배지에서배양하여리보뉴클레아제(ribonuclease) 2 단백질의발현을유도시키는단계;및 b) 상기대장균세포를파쇄한후, 단백질봉입체형태의리보뉴클레아제(ribonuclease) 2를요소와베타-머캅토에탄올을사용하여풀림시킨후, 풀림시킨리보뉴클레아제(ribonuclease) 2를 5-20% 글리세롤혹은 5-20% 프로필렌글리콜용액에서재구성하는단계를포함하는활성형재조합리보뉴클레아제(ribonuclease) 2의제조방법및 그제조방법에의하여제조된단백질에관한것으로, 본발명의방법은특정조건하에서재구성하여높은수율의활성형 RNase 2를제조할수 있었고, 이러한본 발명의재조합단백질은돼지유행성설사병바이러스(PED 바이러스)에대한거의완벽히보호효과를나타내었다. | ||||||
| 18 | Use of a ribonuclease of the T2 family having actin-binding activity for inhibiting tumor angiogenesis | EP10183935.5 | 2000-08-29 | EP2294918B1 | 2012-10-10 | Roiz, Levava; Shoseyov, Oded; Schwartz, Betty; Smirnoff, Patricia |
| The present invention concerns the use of a ribonuclease of the T2 family for the preparation of a medicament for preventing, inhibiting and/or reversing proliferation, colonization, differentiation and/or development of abnormally proliferating cells in a subject, wherein the RNAse T2 has the following characteristics: (i) 5 cysteine-cysteine disulphide bonds; (ii) a molecular weight of between 24-36 kDa; (iii) binds actin in either its active or non-active ribonucleolytic form; and (iv) in the ribonucleolytic form has an optimum temperature range of 50-60 °C and a pH optimum in the acidic range of between 3.5-5. | ||||||
| 19 | Use of a ribonuclease of the T2 family having actin-binding activity for inhibiting and/or reversing proliferation | EP08168000.1 | 2000-08-29 | EP2165605B1 | 2012-10-10 | Roiz, Levava; Schwartz, Betty; Smirnoff, Patricia; Shoseyov, Oded |
| The present invention concerns the use of a ribonuclease of the T2 family for the preparation of a medicament for preventing, inhibiting and/or reversing proliferation, colonization, differentiation and/or development of abnormally proliferating cells in a subject, wherein the RNAse T2 has the following characteristics: (i) 5 cysteine-cysteine disulphide bonds; (ii) a molecular weight of between 24-36 kDa; (iii) binds actin in either its active or non-active ribonucleolytic form; and (iv) in the ribonucleolytic form has an optimum temperature range of 50-60 °C and a pH optimum in the acidic range of between 3.5-5. | ||||||
| 20 | Use of a ribonuclease of the T2 family having actin-binding activity for inhibiting and/or reversing proliferation | EP10183935.5 | 2000-08-29 | EP2294918A1 | 2011-03-16 | Roiz, Levava; Shoseyov, Oded; Schwartz, Betty; Smirnoff, Patricia |
The present invention concerns use of a ribonuclease of the T2 family for the preparation of a medicament for inhibiting angiogenesis in a subject, wherein the ribonuclease of the T2 family binds actin in either its active or non-active ribonucleolytic form. |
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