| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 治疗性核糖核酸酶 | CN200980147889.3 | 2009-10-01 | CN102227443B | 2014-05-14 | T·克林克; J·金克; L·斯特隆 |
| 公开了用于治疗或预防疾病的核糖核酸酶(RNA酶)。所述核糖核酸酶包括具有带下述氨基酸修饰的人RNA酶1序列的核糖核酸酶：R4C、G38R、R39G、N67R、G89R、S90R和V118C。所述核糖核酸酶可重组制备，以用作治疗性制备物。所述核糖核酸酶可以是宿主细胞中所含表达载体中的核酸序列。 | ||||||
| 2 | 治疗性核糖核酸酶 | CN200980147889.3 | 2009-10-01 | CN102227443A | 2011-10-26 | T·克林克; J·金克; L·斯特隆 |
| 公开了用于治疗或预防疾病的核糖核酸酶(RNA酶)。所述核糖核酸酶包括具有带下述氨基酸修饰的人RNA酶1序列的核糖核酸酶：R4C、G38R、R39G、N67R、G89R、S90R和V118C。所述核糖核酸酶可重组制备，以用作治疗性制备物。所述核糖核酸酶可以是宿主细胞中所含表达载体中的核酸序列。 | ||||||
| 3 | Therapeutic ribonucleases | US13545387 | 2012-07-10 | US08628768B2 | 2014-01-14 | Tony Klink; John Kink; Laura Strong |
| The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease. | ||||||
| 4 | Therapeutic ribonucleases | US12572016 | 2009-10-01 | US08029782B2 | 2011-10-04 | Tony Klink; John Kink; Laura Strong |
| The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease. | ||||||
| 5 | COSMETIC USE OF A PROTEIN BELONGING TO THE RIBONUCLEASE FAMILY | US12515198 | 2007-11-16 | US20100311666A1 | 2010-12-09 | Mark Donovan; Dominique Bernard; Isabelle Castiel; Veronique Chaussade |
| The present invention relates to the use, in cosmetics and in therapeutics, of at least one antimicrobial protein belonging to the ribonuclease family, ribonuclease 7, or of polypeptides derived from said protein, notably as a marker for evaluating the condition of the epidermis. It further relates to the use of at least one polypeptide according to the invention, of at least one nucleic acid sequence coding for a polypeptide according to the invention, or of at least one agent that modulates the expression or the activity, notably biological, of said polypeptide or of its interaction with an element of the extracellular matrix, for the preparation of compositions intended for the prevention and/or treatment of skin disorders. | ||||||
| 6 | Cosmetic use of a protein belonging to the ribonuclease family | US12515198 | 2007-11-16 | US09176144B2 | 2015-11-03 | Mark Donovan; Dominique Bernard; Isabelle Castiel; Veronique Chaussade |
| The present invention relates to the use, in cosmetics and in therapeutics, of at least one antimicrobial protein belonging to the ribonuclease family, ribonuclease 7, or of polypeptides derived from said protein, notably as a marker for evaluating the condition of the epidermis. It further relates to the use of at least one polypeptide according to the invention, of at least one nucleic acid sequence coding for a polypeptide according to the invention, or of at least one agent that modulates the expression or the activity, notably biological, of said polypeptide or of its interaction with an element of the extracellular matrix, for the preparation of compositions intended for the prevention and/or treatment of skin disorders. | ||||||
| 7 | THERAPEUTIC RIBONUCLEASES | US14686410 | 2015-04-14 | US20150209415A1 | 2015-07-30 | Tony Klink; John Kink; Laura Strong |
| The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease. | ||||||
| 8 | THERAPEUTIC RIBONUCLEASES | US14149491 | 2014-01-07 | US20140128457A1 | 2014-05-08 | Tony Klink; John Kink; Laura Strong |
| The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease. | ||||||
| 9 | THERAPEUTIC RIBONUCLEASES | US13545387 | 2012-07-10 | US20120276077A1 | 2012-11-01 | Tony Klink; John Kink; Laura Strong |
| The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease. | ||||||
| 10 | Therapeutic ribonuclease | JP2011530249 | 2009-10-01 | JP2012504423A | 2012-02-23 | キンク，ジョン; クリンク，トニー; ストロング，ローラ |
| 疾病の治療または予防において有用なリボヌクレアーゼ（ＲＮａｓｅ）を開示する。 これは、アミノ酸修飾、Ｒ４Ｃ、Ｇ３８Ｒ、Ｒ３９Ｇ、Ｎ６７Ｒ、Ｇ８９Ｒ、Ｓ９０Ｒ、およびＶ１１８Ｃを有するヒトＲＮａｓｅ１配列を有するリボヌクレアーゼを含む。 リボヌクレアーゼは、治療用調製物として使用するために、組換え産生され得る。 リボヌクレアーゼは、宿主細胞に含有される発現ベクター中の核酸配列であり得る。
【選択図】なし |
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| 11 | UTILISATION COSMETIQUE D'UNE PROTEINE DE LA FAMILLE DES RIBONUCLEASES | EP07870293.3 | 2007-11-16 | EP2089720A2 | 2009-08-19 | DONOVAN, Mark; BERNARD, Dominique; CASTIEL, Isabelle; CHAUSSADE, Véronique |
| The object of the invention is the use in cosmetics and therapeutics, of at least one anti-microbial protein belonging to the ribonuclease family, namely ribonuclease 7, or of polypeptides derived from this protein, particularly as markers for the evaluation of the state of the epidermis. The invention also relates to the use of at least one polypeptide according to the invention, of at least one nucleic acid sequence coding for a polypeptide according to the invention, and of at least one modulator agent of the expression or the activity, particularly the biological activity, of said polypeptide or of its interaction with an extracellular matrix component, for the preparation of compositions for the prevention and/or treatment of skin disorders. <0} | ||||||
| 12 | UTILISATION COSMETIQUE D'UNE PROTEINE DE LA FAMILLE DES RIBONUCLEASES | EP07870293.3 | 2007-11-16 | EP2089720B1 | 2017-04-12 | DONOVAN, Mark; BERNARD, Dominique; CASTIEL, Isabelle; CHAUSSADE, Véronique |
| 13 | Therapeutic ribonucleases | US14686410 | 2015-04-14 | US09579365B2 | 2017-02-28 | Tony Klink; John Kink; Laura Strong |
| The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease. | ||||||
| 14 | Therapeutic ribonucleases | US14149491 | 2014-01-07 | US09006407B2 | 2015-04-14 | Tony Klink; John Kink; Laura Strong |
| The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease. | ||||||
| 15 | Therapeutic ribonucleases | US13231050 | 2011-09-13 | US08216567B2 | 2012-07-10 | Tony Klink; John Kink; Laura Strong |
| The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease. | ||||||
| 16 | THERAPEUTIC RIBONUCLEASES | US13231050 | 2011-09-13 | US20120003150A1 | 2012-01-05 | Tony Klink; John Kink; Laura Strong |
| The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease. | ||||||
| 17 | THERAPEUTIC RIBONUCLEASES | US12572016 | 2009-10-01 | US20100080789A1 | 2010-04-01 | Tony Klink; John Kink; Laura Strong |
| The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease. | ||||||
| 18 | 治療用リボヌクレアーゼ | JP2015112793 | 2015-06-03 | JP6014206B2 | 2016-10-25 | クリンク,トニー; キンク,ジョン; ストロング,ローラ |
| 19 | 治療用リボヌクレアーゼ | JP2015112793 | 2015-06-03 | JP2015187139A | 2015-10-29 | クリンク,トニー; キンク,ジョン; ストロング,ローラ |
| 【課題】疾病の治療又は予防におけるタンパク質治療剤は、小分子に代わり特定の利点を提供するが、有効なタンパク質薬物は、特異性、細胞傷害性、標的に対する親和性、安全性、溶解度、有効な送達に対する従順さ、安定性、及び体内での寿命(除去時間)を含む最適な特性の均衡を有さなければならないが、これらの特性のうちのいずれか1つに優位性を有する候補薬は、有効な薬として役立つために最適な、特徴の全体的均衡を持たない可能性のため、当該特徴を効果的に補完する更なる抗癌化学療法剤の提供。 【解決手段】アミノ酸修飾、R4C、G38R、R39G、N67R、G89R、S90R、及びV118Cを有するヒトRNase1配列を有するリボヌクレアーゼを含み、前記リボヌクレアーゼは癌に対する治療活性を有し、かつ、ヒトRNase 1の1%未満のリボヌクレアーゼ活性を有する、組成物。 【選択図】なし |
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| 20 | THERAPEUTIC RIBONUCLEASES | EP09818521.8 | 2009-10-01 | EP2334695B1 | 2015-12-23 | KLINK, Tony; KINK, John; STRONG, Laura |
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