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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
1	New method	US10416456	2003-09-16	US20040253728A1	2004-12-16	Claes Gustafsson; Nils-Goran Larsson
Apoptosis can be induced in a mammalian cell by administering a substance capable of impairing mammalian mitochondrial DNA gene expression to said cell in such an amount that apoptosis is induced. Certain antisense nucleic acid molecules specifically binding to nucleic acid molecules encoding proteins affecting mitochondrial gene expression are preferably used. The invention also provides novel such antisense nucleic acid molecules and pharmaceutical compositions containing the novel compounds. The invention also describes the use of an in vitro assay consisting of TFAM, TFB1M, TFB2M, mtRNAP and a mtDNA promoter fragment, to identify substances that inhibit or stimulate mtDNA transcription.
2	And molecular interaction site of Rn-ase prna, how to modulate the same site	JP2003521807	2002-08-19	JP2005503148A	2005-02-03	エッカー，デービッド・ジェイ
特定の二次構造を有する、ＲＮアーゼＰＲＮＡの分子相互作用部位を含むポリヌクレオチドを提供する。該ポリヌクレオチドに結合する化合物のコンビナトリアル・ライブラリーを仮想的又は現実的にスクリーニングするためのこのようなポリヌクレオチドの使用方法も提供する。ＲＮアーゼＰＲＮＡ又はこれを含有する原核細胞の活性を、このような仮想的又は現実的スクリーニングによって同定される化合物によってモジュレートする方法も提供する。
3	METHODS OF USING RNASE P REACTION MECHANISMS OF ACTION	EP00932665.3	2000-05-19	EP1183333A1	2002-03-06	LEHR, Ruth, V.; SPITZFADEN, Claus; NICHOLSON, Neville; JONES, Joanna
This invention relates to a novel bacterial ribonucleoprotein complex and the component parts thereof. More specifically, this invention relates to RNase P RNA isolated from Staphylococcus aureus and the use of RNase P RNA in screens for the identification of antimicrobial compounds and to the use of such compounds in therapy.
4	A method of using the mechanism of action of the reaction of RNaseP	JP2000618431	2000-05-19	JP2002544507A	2002-12-24	クラウス・シュピッツファーデン; ジョアンナ・ジョーンズ; ネビル・ニコルソン; ルース・ブイ・レーア
(57)【要約】本発明は新規な細菌リボ核蛋白およびその成分部分に関する。さらに詳しくは、本発明はスタフィロコッカス・アウレウスから単離されたＲＮａｓｅＰＲＮＡおよび抗菌化合物を同定するためのスクリーニングにおけるＲＮａｓｅＰＲＮＡの使用ならびに治療におけるその化合物の使用に関する。
5	New rnasep	JP2000508691	1998-09-03	JP2001514025A	2001-09-11	エイミー・エム・シャッペル; キャサリン・ディ・プレスコット; フ・リ; マイケル・ジェイ・グレス; リサ・エイ・ヘッグ
(57)【要約】本発明は、新規リボヌクレオ蛋白複合体およびその構成成分に関する。より詳細には、本発明は、エス・ニューモニアエから単離されたＲＮａｓｅＰならびに抗微生物化合物の同定のためのスクリーニングにおけるＲＮａｓｅＰまたはその成分の使用ならびに治療におけるかかる化合物の使用に関する。
6	MOLECULAR INTERACTION SITES OF RNASE P RNA AND METHODS OF MODULATING THE SAME	EP02768616.1	2002-08-19	EP1425292A2	2004-06-09	ECKER, David, J.
Polynucleotides comprising molecular interaction sites of RNase P RNA that have particular secondary structure are provided. Methods of using such polynucleotides to screen, virtually or actually, combinatorial libraries of compounds that bind thereto are also provided. Method of modulating the activity of RNase P RNA by contacting RNase P RNA or prokaryotic cells containing the same with a compound identified by such virtual or actual screening are also provided.
7	METHOD FOR INDUCING APOPTIOSIS	EP01983032.2	2001-11-12	EP1331949A2	2003-08-06	GUSTAFSSON, Claes; LARSSON, Nils-Göran
Apoptosis can be induced in a mammalian cell by administering a substance capable of impairing mammalian mitochondrial DNA gene expression to said cell in such an amount that apoptosis is induced. Certain antisense nucleic acid molecules specifically binding to nucleic acid molecules encoding proteins affecting mitochondrial gene expression are preferably used. The invention also provides novel such antisense nucleic acid molecules and pharmaceutical compositions containing the novel compounds. The invention also describes the use of an in vitro assay consisting of TFAM, TFB1M, TFB2M, mtRNAP and a mtDNA promoter fragment, to identify substances that inhibit or stimulate mtDNA transcription.
8	METHODS OF USING RNASE P REACTION MECHANISMS OF ACTION	EP00932665	2000-05-19	EP1183333A4	2002-09-11	LEHR RUTH V; SPITZFADEN CLAUS; NICHOLSON NEVILLE; JONES JOANNA

9	NOVEL RNASE P	EP98945852.6	1998-09-03	EP1019431A1	2000-07-19	GRESS, Michael, J.; HEGG, Lisa, A.; LI, Hu; PRESCOTT, Catherine, D.; SHAPPELL, Amy, M.
This invention relates to a novel bacterial ribonucleoprotein complex and the component parts thereof. More specifically, this invention relates to RNase P isolated from S. pneumoniae and the use of RNase P or components thereof in screens for the identification of antimicrobial compounds and to the use of such compounds in therapy.
10	MOLECULAR INTERACTION SITES OF RNASE P RNA AND METHODS OF MODULATING THE SAME	PCT/US0226418	2002-08-19	WO03016498A2	2003-02-27	ECKER DAVID J
Polynucleotides comprising molecular interaction sites of RNase P RNA that have particular secondary structure are provided. Methods of using such polynucleotides to screen, virtually or actually, combinatorial libraries of compounds that bind thereto are also provided. Method of modulating the activity of RNase P RNA by contacting RNase P RNA or prokaryotic cells containing the same with a compound identified by such virtual or actual screening are also provided.
11	NEW METHOD	PCT/SE0102501	2001-11-12	WO0238759A2	2002-05-16	GUSTAFSSON CLAES; LARSSON NILS-GOERAN
Apoptosis can be induced in a mammalian cell by administering a substance capable of impairing mammalian mitochondrial DNA gene expression to said cell in such an amount that apoptosis is induced. Certain antisense nucleic acid molecules specifically binding to nucleic acid molecules encoding proteins affecting mitochondrial gene expression are preferably used. The invention also provides novel such antisense nucleic acid molecules and pharmaceutical compositions containing the novel compounds. The invention also describes the use of an in vitro assay consisting of TFAM, TFB1M, TFB2M, mtRNAP and a mtDNA promoter fragment, to identify substances that inhibit or stimulate mtDNA transcription.
12	NOVEL RNASE P	PCT/US9818291	1998-09-03	WO9911653A9	1999-06-03	GRESS MICHAEL J; HEGG LISA A; LI HU; PRESCOTT CATHERINE D; SHAPPELL AMY M
This invention relates to a novel bacterial ribonucleoprotein complex and the component parts thereof. More specifically, this invention relates to RNase P isolated from S. pneumoniae and the use of RNase P or components thereof in screens for the identification of antimicrobial compounds and to the use of such compounds in therapy.

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