序号 专利名 申请号 申请日 公开(公告)号 公开(公告)日 发明人
1 METHOD FOR PRODUCING DITERPENES PCT/IB2008053973 2008-09-30 WO2009044336A2 2009-04-09 SCHALK MICHEL
The present invention provides a method of producing diterpene compounds, said method comprising contacting a particular polypeptide having a diterpene synthase activity with the diterpene precursor geranylgeranyl pyrophosphate (GGPP). In particular, said method may be carried out in vitro or in vivo to produce labdenediol diphosphate, labdenediol and/or sclareol, which are very useful compounds in the fields of perfumery and flavoring. The present invention also provides the amino acid sequence of the polypeptide used in the method. A nucleic acid derived from Salvia sclarea and encoding the polypeptide of the invention, an expression vector containing said nucleic acid, as well as a non-human organism or a cell transformed to harbor the same nucleic acid, are also part of the present invention.
2 METHOD FOR PRODUCING DITERPENES PCT/IB2008053973 2008-09-30 WO2009044336A3 2009-05-28 SCHALK MICHEL
The present invention provides a method of producing diterpene compounds, said method comprising contacting a particular polypeptide having a diterpene synthase activity with the diterpene precursor geranylgeranyl pyrophosphate (GGPP). In particular, said method may be carried out in vitro or in vivo to produce labdenediol diphosphate, labdenediol and/or sclareol, which are very useful compounds in the fields of perfumery and flavoring. The present invention also provides the amino acid sequence of the polypeptide used in the method. A nucleic acid derived from Salvia sclarea and encoding the polypeptide of the invention, an expression vector containing said nucleic acid, as well as a non-human organism or a cell transformed to harbor the same nucleic acid, are also part of the present invention.
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