| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 具有降低的ppGppase活性的细胞 | CN201380020352.7 | 2013-01-28 | CN104583388A | 2015-04-29 | F·施耐德; C·格特 |
| 本发明涉及相对于其野生型经遗传学修饰的细胞，由此相对于其野生型其具有降低的ppGppase活性，并且优选地过量产生必需氨基酸、更优选衍生自丝氨酸的必需氨基酸、最优选甲硫氨酸或色氨酸，涉及包含这种细胞的饲料添加剂，涉及制备过量产生必需氨基酸、优选衍生自丝氨酸的必需氨基酸、最优选甲硫氨酸或色氨酸的细胞的方法，所述方法包括制备具有编码ppGppase的基因敲除的细胞，还涉及制备必需氨基酸、优选衍生自丝氨酸的必需氨基酸、最优选甲硫氨酸或色氨酸的方法，包括步骤a)培养根据本发明的第一方面或任何其实施方案的细胞，及b)任选纯化所述氨基酸。 | ||||||
| 2 | CELL WITH REDUCED PPGPPASE ACTIVITY | US15357482 | 2016-11-21 | US20170067066A1 | 2017-03-09 | Frank Schneider; Caroline Gerth |
| The present invention relates to a cell which is genetically modified over its wild type in such a way that it has a reduced ppGppase activity relative to its wild type, and preferably an essential amino acid, even more preferably an essential amino acid derived from serine, most preferably methionine or tryptophan, to a feed additive comprising such a cell, to a method of preparing a cell overproducing essential amino acid, more preferably an essential amino acid derived from serine, most preferably methionine or tryptophan, comprising preparing a cell having a knocked-out gene coding for a ppGppase, and to a method of preparing an essential amino acid, more preferably an essential amino acid derived from serine, most preferably methionine or tryptophan, comprising the steps of a) culturing the cell according to the first aspect of the present invention or to any of its embodiments, and b) optionally: purifying the amino acid. | ||||||
| 3 | CELL WITH REDUCED PPGPPASE ACTIVITY | US14375940 | 2013-01-28 | US20150072382A1 | 2015-03-12 | Frank Schneider; Caroline Gerth |
| The present invention relates to a cell which is genetically modified over its wild type in such a way that it has a reduced ppGppase activity relative to its wild type, and preferably an essential amino acid, even more preferably an essential amino acid derived from serine, most preferably methionine or tryptophan, to a feed additive comprising such a cell, to a method of preparing a cell overproducing essential amino acid, more preferably an essential amino acid derived from serine, most preferably methionine or tryptophan, comprising preparing a cell having a knocked-out gene coding for a ppGppase, and to a method of preparing an essential amino acid, more preferably an essential amino acid derived from serine, most preferably methionine or tryptophan, comprising the steps of a) culturing the cell according to the first aspect of the present invention or to any of its embodiments, and b) optionally: purifying the amino acid. | ||||||
| 4 | 低下したｐｐＧｐｐアーゼ活性を有する細胞 | JP2014556972 | 2013-01-28 | JP2015508647A | 2015-03-23 | シュナイダー フランク; ゲアト カロリーネ |
| 本発明は、その野生型に対して低下したppGppアーゼ活性を有し且つ好ましくは必須アミノ酸、更に一層好ましくはセリン由来の必須アミノ酸、最も好ましくはメチオニン又はトリプトファンを過剰生産するように、その野生型に対して遺伝的に改変された細胞に関し、かかる細胞を含む試料添加剤に関し、必須アミノ酸、更に好ましくはセリン由来の必須アミノ酸、最も好ましくはメチオニン又はトリプトファンを過剰生産する細胞の製造方法であって、ppGppアーゼをコードするノックアウト遺伝子を有する細胞の製造を含む、前記製造方法に関し、且つ必須アミノ酸、更に好ましくはセリン由来の必須アミノ酸、最も好ましくはメチオニン又はトリプトファンの製造方法であって、a)本発明の第1の態様による又はその実施態様のいずれかによる細胞を培養する工程、及びb)任意にアミノ酸を精製する工程を含む、前記製造方法に関する。 | ||||||
| 5 | A CELL WITH REDUCED PPGPPASE ACTIVITY | EP13701624.2 | 2013-01-28 | EP2814945B9 | 2017-11-22 | SCHNEIDER, Frank; GERTH, Caroline |
| 6 | A CELL WITH REDUCED PPGPPASE ACTIVITY | EP13701624.2 | 2013-01-28 | EP2814945B1 | 2017-08-02 | SCHNEIDER, Frank; GERTH, Caroline |
| 7 | A CELL WITH REDUCED PPGPPASE ACTIVITY | EP13701624.2 | 2013-01-28 | EP2814945A1 | 2014-12-24 | SCHNEIDER, Frank; GERTH, Caroline |
| The present invention relates to a cell which is genetically modified over its wild type in such a way that it has a reduced ppGppase activity relative to its wild type, and preferably an essential amino acid, even more preferably an essential amino acid derived from serine, most preferably methionine or tryptophan, to a feed additive comprising such a cell, to a method of preparing a cell overproducing essential amino acid, more preferably an essential amino acid derived from serine, most preferably methionine or tryptophan, comprising preparing a cell having a knocked-out gene coding for a ppGppase, and to a method of preparing an essential amino acid, more preferably an essential amino acid derived from serine, most preferably methionine or tryptophan, comprising the steps of a) culturing the cell according to the first aspect of the present invention or to any of its embodiments, and b) optionally: purifying the amino acid. | ||||||
| 8 | Zelle mit verringerter ppGppase-Aktivität | EP12156052.8 | 2012-02-17 | EP2628792A1 | 2013-08-21 | Schneider, Frank; Gerth, Caroline |
Die vorliegende Erfindung betrifft eine Zelle, die ihrem Wildtyp gegenüber derartig genetisch verändert ist, dass sie eine relativ zu ihrem Wildtyp verringerte ppGppase-Aktvität aufweist und bevorzugt eine essentielle Aminosäure, noch bevorzugter eine von Serin abgeleitete essentielle Aminosäure, am bevorzugtesten Methionin oder Tryptophan, ein Futtermitteladditiv umfassend eine solche Zelle, ein Verfahren zur Herstellung einer essentiellen Aminosäure, bevorzugter einer von Serin abgeleiteten essentiellen Aminosäure, am bevorzugtesten Methionin oder Tryptophan, überproduzierenden Zelle, umfassend Herstellen einer Zelle mit einem Knock out eines für eine ppGppase kodierenden Gens, sowie ein Verfahren zur Herstellung einer essentiellen Aminosäure, bevorzugter einer von Serin abgeleiteten essentiellen Aminosäure, am bevorzugtesten Methionin oder Tryptophan, umfassend die Schritte a) Kultivieren der Zelle nach dem ersten Aspekt der vorliegenden Erfindung oder einer seiner Ausführungsformen, und b) optional: Aufreinigen der Aminosäure. |
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| 9 | 고인산화 구아노신 뉴클레오티드 합성효소 ｒｅｌＡ 유전자 및 이의 항생물질 발현증가 용도 | KR1020100003651 | 2010-01-14 | KR1020110083430A | 2011-07-20 | 황용일; 최선욱; 조양호; 유동민; 이성구; 유희종 |
| PURPOSE: A guanosine nucleotide biosynthetic relA gene of high phosphorylation is provided to induce natamycin expression and to cheaply produce natamycin antibiotics. CONSTITUTION: A guanosine nucleotide biosynthetic relA gene of high phosphorylation encodes a protein having an amino acid of sequence number 2. The gene has a base sequence of sequence number 1. relA protein has an amino acid sequence of sequence number 2. A recombinant vector, pSET152ET_relA contains the relA gene. A host cell transformed by the recombinant vector is Actinomyces. A composition for enhancing antibiotics expression contains the gene or protein thereof as an active ingredient. | ||||||
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