专利检索_ ..[羟甲基戊二酰 -辅酶A还原酶专利检索_ ..[羟甲基戊二酰 -辅酶A还原酶专利检索查询

序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
1	合成的表没食子儿茶素没食子酸酯(EGCG)类似物	CN201280039953.8	2012-06-15	CN104024213A	2014-09-03	德恒·陈; 斯里达尔·帕穆; 庆平·窦; 迪·陈
本申请提供了合成的式(I)多酚类化合物、其合成方法和其药物组合物。本申请还提供了本文所述的化合物和组合物用于治疗癌症和用于治疗代谢紊乱的用途。
2	AMPK ACTIVATOR SCREENING METHOD, AND AMPK ACTIVATOR	US14400945	2013-05-16	US20150126387A1	2015-05-07	Tomohiro Ide; Naoki Kobayashi; Yunike Akasaka; Takashi Komine; Koji Murakami
A method for screening an AMPK activator, wherein inhibition of an interaction between prohibitin and AMPK is used as an index is provided. Besides, an AMPK activator comprising, as an active ingredient, a compound inhibiting an interaction between prohibitin and AMPK, and a prohibitin-AMPK complex are also provided.
3	ONE CLASS OF PYRAZOLONE COMPOUNDS AND USE THEREOF	US15326310	2015-07-14	US20170247371A1	2017-08-31	Fajun NAN; Jia LI; Jingya LI; Mei ZHANG; Dakai CHEN; Lina ZHANG; Runtao ZHANG; Zhifu XIE
Provided are a class of pyrazolone compounds and a use thereof. In particular, a compound represented by formula I is provided, wherein the definition of each variable group is as described in the description. The compounds of formula (I) have a direct AMPK-activating activity and can significantly promote the phosphorylation of AMPK and ACC of L6 myocytes and HepG2 cells in a dose-dependent manner.
4	Fluorescent AMP-Kinase Biosensors	US15319646	2015-06-18	US20170205400A1	2017-07-20	Imre Berger; Martin Pelosse; Uwe Schlattner
The present invention deals with heterotrimeric AMP-activated protein kinase (AMPK) comprising a fluorophore pair wherein the conformational change can be measured by FRET. It represents an advanced tool to screen and identify AMPK interactors in vitro and in cells in vivo. Such invention can also be considered as a reporter of the cellular energy status as it allows the spatiotemporal monitoring, in situ, of fluctuations in the ratio of AMP and ADP versus ATP.
5	Carboxamide, Sulfonamide and Amine Compounds and Methods for Using Them	US14376098	2013-01-31	US20140378429A1	2014-12-25	Dane Goff; Donald Payan; David Carroll; Simon Shaw; Hitoshi Yasumichi
The disclosure relates particularly to certain carboxamide, sulfonamide and amine compounds and pharmaceutical compositions thereof, and to methods of treating and ameliorating disorders and conditions related to the adiponectin pathway, sphingolipid metabolism, oxidative stress, mitochondrial dysfunction, free radical damage and metabolic inefficiency, among others. In certain embodiments, the compounds have the structures (I-1), (2-I) and (3-I) (The chemical formulas should be inserted here) in which the variables are as described herein.
6	AMPK activator screening method, and AMPK activator	US14400945	2013-05-16	US09863955B2	2018-01-09	Tomohiro Ide; Naoki Kobayashi; Yunike Akasaka; Takashi Komine; Koji Murakami
A method for screening an AMPK activator, wherein inhibition of an interaction between prohibitin and AMPK is used as an index is provided. Besides, an AMPK activator comprising, as an active ingredient, a compound inhibiting an interaction between prohibitin and AMPK, and a prohibitin-AMPK complex are also provided.
7	5- or 6-substituted benzofuran-2-carboxamide compounds and methods for using them	US14376098	2013-01-31	US09409884B2	2016-08-09	Dane Goff; Donald Payan; David Carroll; Simon Shaw; Hitoshi Yasumichi
The disclosure relates particularly to certain carboxamide, sulfonamide and amine compounds and pharmaceutical compositions thereof, and to methods of treating and ameliorating disorders and conditions related to the adiponectin pathway, sphingolipid metabolism, oxidative stress, mitochondrial dysfunction, free radical damage and metabolic inefficiency, among others. In certain embodiments, the compounds have the structures (I-1), (2-I) and (3-I) in which the variables are as described herein.
8	Synthetic Epigallocatechin Gallate (EGCG) Analogs	US14126667	2012-06-15	US20140378541A1	2014-12-25	Tak-Hang Chan; Sreedhar Pamu; Qing Ping Dou; Di Chen
Synthetic polyphenolic compounds of formula (I), their modes of synthesis, and pharmaceutical compositions thereof are provided herein. Use of the compounds and compositions described herein for treating cancer and for treating metabolic disorders is also provided.
9	ピラゾロン化合物およびその使用	JP2017502142	2015-07-14	JP6408687B2	2018-10-17	ナン,ファージュン; リー,ジャー; リー,ジンヤー; ツァン,メイ; チェン,ダーカイ; ツァン,リーナー; ツァン,ランタオ; シエ,ツィーフー

10	AMPKタンパク質活性化剤のスクリーニング方法及びAMPKタンパク質活性化剤	JP2014515674	2013-05-16	JP6174018B2	2017-08-02	井出智広; 小林直樹; 赤坂ゆにけ; 小峰隆史; 村上浩二

11	Synthetic epigallocatechin gallate (egcg) analogues	JP2014515012	2012-06-15	JP2014523413A	2014-09-11	チャン，タク−ハン; パム，スリダール; ドウ，シンピン; チェン，ディ
式（Ｉ）の合成ポリフェノール化合物、それらの合成様式、およびそれらの薬学的組成物を本明細書に提供する。癌を治療するためおよび代謝障害を治療するための本明細書に記載される化合物および組成物の使用も提供する。【選択図】なし
12	AMPK PROTEIN ACTIVATOR SCREENING METHOD, AND AMPK PROTEIN ACTIVATOR	EP13790343.1	2013-05-16	EP2851686A1	2015-03-25	IDE, Tomohiro; KOBAYASHI, Naoki; AKASAKA, Yunike; KOMINE, Takashi; MURAKAMI, Koji
A method for screening an AMPK activator, wherein inhibition of an interaction between prohibitin and AMPK is used as an index is provided. Besides, an AMPK activator comprising, as an active ingredient, a compound inhibiting an interaction between prohibitin and AMPK, and a prohibitin-AMPK complex are also provided.
13	ピラゾロン化合物およびその使用	JP2017502142	2015-07-14	JP2017521444A	2017-08-03	ナン，ファージュン; リー，ジャー; リー，ジンヤー; ツァン，メイ; チェン，ダーカイ; ツァン，リーナー; ツァン，ランタオ; シエ，ツィーフー
本発明は、1種類のピラゾロン化合物およびその使用を、具体的に、以下の一般式Iで表される化合物を提供する。ここで、各基の基は明細書に記載された通りである。本発明の化合物は直接AMPKを活性化させる活性を有し、投与量に依存して顕著にL6筋細胞およびHepG2細胞のAMPKおよびACCのリン酸化を促進することができる。
14	ＡＭＰＫタンパク質活性化剤のスクリーニング方法及びＡＭＰＫタンパク質活性化剤	JP2014515674	2013-05-16	JPWO2013172421A1	2016-01-12	智広井出; 小林　直樹; 小林　　直樹; ゆにけ赤坂; 隆史小峰; 村上　浩二; 浩二村上
プロヒビチンタンパク質とAMPKタンパク質との相互作用の阻害を指標とする、AMPKタンパク質活性化剤のスクリーニング方法が提供される。また、プロヒビチンタンパク質とAMPKタンパク質との相互作用を阻害する化合物を有効成分とするAMPKタンパク質活性化剤、及びプロヒビチンタンパク質−AMPKタンパク質複合体も提供される。
15	항노화 형질전환 예쁜꼬마선충	KR1020160049947	2016-04-25	KR1020170121757A	2017-11-03	남홍길; 정규열; 이승재; 황우선; 신기원; 서미화
본발명은, 글루타민 tRNA 5' 말단유래의단편(Gln 5' tRF)이과발현된형질전환예쁜꼬마선충, 이의제조방법, 및상기형질전환예쁜꼬마선충을이용한노화관련인자의스크리닝방법에관한것이다. 본발명에서제공하는형질전환예쁜꼬마선충모델은, 글루타민 tRNA 5' 말단유래의단편(Gln 5' tRF)이과발현되어노화가억제된동물모델로서, 본발명의모델을이용하면항노화메커니즘을손쉽게규명할수 있고, 이를통하여항노화신약개발, 노화유도물질스크리닝등 다양한연구분야에서크게기여할수 있을것이다.
16	ONE CLASS OF PYRAZOLONE COMPOUNDS AND USE THEREOF	EP15822833	2015-07-14	EP3170823A4	2018-01-03	NAN FAJUN; LI JIA; LI JINGYA; ZHANG MEI; CHEN DAKAI; ZHANG LINA; ZHANG RUNTAO; XIE ZHIFU
Provided in the present invention are one class of pyrazolone compounds and a use thereof. In particular, provided in the present invention is a compound as represented by general formula I, wherein the definition of each group is as described in the description. The compounds of the present invention have a direct AMPK-activating activity and can significantly promote the phosphorylation of AMPK and ACC of L6 myocytes and HepG2 cells in a dose-dependent manner.
17	AMPK PROTEIN ACTIVATOR SCREENING METHOD, AND AMPK PROTEIN ACTIVATOR	EP13790343	2013-05-16	EP2851686A4	2016-05-18	IDE TOMOHIRO; KOBAYASHI NAOKI; AKASAKA YUNIKE; KOMINE TAKASHI; MURAKAMI KOJI
A method for screening an AMPK activator, wherein inhibition of an interaction between prohibitin and AMPK is used as an index is provided. Besides, an AMPK activator comprising, as an active ingredient, a compound inhibiting an interaction between prohibitin and AMPK, and a prohibitin-AMPK complex are also provided.
18	SYNTHETIC EPIGALLOCATECHIN GALLATE (EGCG) ANALOGS	EP12801360	2012-06-15	EP2721000A4	2015-03-25	CHAN TAK-HANG; PAMU SREEDHAR; DOU QING PING; CHEN DI

19	SYNTHETIC EPIGALLOCATECHIN GALLATE (EGCG) ANALOGS	EP12801360.4	2012-06-15	EP2721000A1	2014-04-23	CHAN, Tak-Hang; PAMU, Sreedhar; DOU, Qing Ping; CHEN, Di
Synthetic polyphenolic compounds of formula (I), their modes of synthesis, and pharmaceutical compositions thereof are provided herein. Use of the compounds and compositions described herein for treating cancer and for treating metabolic disorders is also provided.

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