1 |
Visualization of P-TEFb by Fluorescence Complementation |
US14932611 |
2015-11-04 |
US20160123957A1 |
2016-05-05 |
Boris Peterlin; Koh Fujinaga |
Provided herein is a novel assay for the quantification of P-TEFb activation in living cells. The invention, in one embodiment, comprises cells which express P-TEFb and a P-TEFb-phosphorylated or P-TEFb-binding species, for example the C terminal domain of RNA polymerase II. Each of the P-TEFb and P-TEFb-phosphorylated or P-TEFb-binding species comprises a complementary signal moiety, for example complementary fragments of a fluorescent protein, such that when the P-TEFb interacts with the P-TEFb-phosphorylated or P-TEFb-binding species, the signal moieties are in sufficiently close proximity to generate a detectable signal. |
2 |
당결합 페녹소다이올 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물 |
KR1020140148405 |
2014-10-29 |
KR1020160050383A |
2016-05-11 |
박제원 |
본발명은하기화학식 1로표시되는화합물, 또는이의약학적으로허용가능한염에관한것이다. [화학식 1](상기식에서, R은갈락토오스(galactose) 또는 2˝-디옥시-글루코오스(2˝-deoxy-glucose)임.) 본발명에따른상기화학식 1의화합물, 또는이의약학적으로허용가능한염은항산화활성및 전립선암과난소암에대하여항암활성효과를나타내어, 관련질환의예방및 치료에유용하게사용될수 있다. |