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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
1	Human cytidine monophosphate (cmp) kinase cdna	US10362332	2001-08-15	US20050100998A1	2005-05-12	Stephen Prescott; A. Pearman; Hugo Castro-Faria-Neto; Diana Stafforini; Thomas McIntyre
The present invention provides the cDNA for a novel nucleoside/nucleotide monophosphate kinase cloned from a human macrophage cDNA library. This kinase is able to phosphorylate UMP and utilize multiple phosphate donors, but has demonstrated a preference for transferring a phosphate from ATP or UTP to cytidine monophosphate (CTP). The kinase is thus referred to as cytidine monophosphate (CMP) kinase. This kinase is shown to be a Mg2+ dependent nucleotide kinase which codes for two ubiquitously transcribed mRNA splice products of 3.2 and 2.0 kb, and has been mapped to chromosome 1, region p32-34.1, a region known to contain other nucleotide modifying enzyme genes.
2	Modulating the Rad-nm23 interaction	US10074694	2002-02-12	US20030013673A1	2003-01-16	C. Ronald Kahn; Jianhua Zhu
The present invention is based on the discovery of a novel bimolecular, bidirectional mechanism of regulation between nm23 and Rad. Accordingly, the present invention provides a method of modulating an activity of nm23 in a subject at risk for a proliferative disorder, comprising: modulating the level of Rad activity.
3	Hitoshichijin monophosphate (CMP) kinase cDNA	JP2002521474	2001-08-15	JP2004506440A	2004-03-04	カストロ−ファリア−ネト、ヒューゴ; スタッフォリーニ、ダイアナ; ピアマン、テラス; プレスコット、スティーブン; マッキンタイア、トーマス
本発明は、ヒトマクロファージｃＤＮＡライブラリからクローニングされた新規なヌクレオシド／ヌクレオチド一リン酸キナーゼｃＤＮＡを提供する。このキナーゼは、ＵＭＰをリン酸化し、多くのリン酸供与体を利用することができるが、リン酸をＡＴＰまたはＵＴＰからシチジン一リン酸（ＣＭＰ）に転移させる選択性を示した。したがって、このキナーゼはシチジン一リン酸（ＣＭＰ）キナーゼと称される。このキナーゼは、３．２ｋｂと２．０ｋｂの２種の遍在的に転写されるｍＲＮＡスプライス産物をコードするＭｇ ^２＋依存性ヌクレオチドキナーゼであることが示され、他のヌクレオチド修飾酵素遺伝子を含むことが知られている領域である１番染色体のｐ３２〜３４．１領域にマッピングされた。
4	HUMAN CYTIDINE MONOPHOSPHATE (CMP) KINASE CDNA	EP01967986.9	2001-08-15	EP1311528A2	2003-05-21	PRESCOTT, Stephen; PEARMAN, Terrece; CASTRO-FARIA-NETO, HugoHuntsman Cancer Institute; STAFFORINI, Diana; MCINTYRE, Thomas
The present invention provides the cDNA for a novel nucleoside/nucleotide monophosphate kinase cloned from a human macrophage cDNA library. This kinase is able to phosphorylate UMP and utilize multiple phosphate donors, but has demonstrated a preference for transferring a phosphate from ATP or UTP to cytidine monophosphate (CMP). The kinase is thus referred to as cytidine monophosphate (CMP) kinase. This kinase is shown to be a Mg2+ dependent nucleotide kinase which codes for two ubiquitously transcribed mRNA splice products of 3.2 and 2.0 kb, and has been mapped to chromosome 1, region p32-34.1, a region known to contain other nucleotide modifying enzyme genes.
5	HUMAN CYTIDINE MONOPHOSPHATE (CMP) KINASE CDNA	PCT/US0125567	2001-08-15	WO0216377A3	2002-05-10	PRESCOTT STEPHEN; PEARMAN TERRECE; CASTRO-FARIA-NETO HUGO; STAFFORINI DIANA; MCINTYRE THOMAS
The present invention provides the cDNA for a novel nucleoside/nucleotide monophosphate kinase cloned from a human macrophage cDNA library. This kinase is able to phosphorylate UMP and utilize multiple phosphate donors, but has demonstrated a preference for transferring a phosphate from ATP or UTP to cytidine monophosphate (CMP). The kinase is thus referred to as cytidine monophosphate (CMP) kinase. This kinase is shown to be a Mg2+ dependent nucleotide kinase which codes for two ubiquitously transcribed mRNA splice products of 3.2 and 2.0 kb, and has been mapped to chromosome 1, region p32-34.1, a region known to contain other nucleotide modifying enzyme genes.
6	MODULATING THE RAD-NM23 INTERACTION	PCT/US9806521	1998-04-02	WO9844088A3	1999-02-25	KAHN C RONALD; ZHU JINHUA
The present invention is based on the discovery of a novel bimolecular, bi-directional mechanism of regulation between nm23 and Rad. Accordingly, the present invention provides a method of modulating an activity of nm23 in a subject at risk for a proliferative disorder, comprising: modulating the level of Rad activity.

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