| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 41 | IMMUNOGENIC PROTEINS AGAINST CLOSTRIDIUM DIFFICILE | US15992497 | 2018-05-30 | US20180344834A1 | 2018-12-06 | Xingmin Sun |
| Described are immunogenic proteins against Clostridium difficile. Also described are compositions comprising the immunogenic proteins. Further described are methods of preventing or treating a Clostridium difficile infection in a subject in need thereof. | ||||||
| 42 | Glycosyltransferase glycosylating flavokermesic acid and/or or kermesic acid | US15105673 | 2014-12-18 | US10100290B2 | 2018-10-16 | Rubini Maya Kannangara; Mads Bennedsen; Bjørn Madsen; Kim Binderup; Ulf Thrane; Rasmus John Normand Frandsen; Uffe Hasbro Mortensen; Birger Lindberg Møller; Finn Thyge Okkels |
| An isolated glycosyltransferase (GT) polypeptide capable of: (I): conjugating glucose to flavokermesic acid (FK); and/or (II): conjugating glucose to kermesic acid (KA) and use of this GT to e.g. make Carminic acid. | ||||||
| 43 | Method for using hexenol glycosyl transferase | US14908889 | 2014-08-01 | US09957539B2 | 2018-05-01 | Eiichiro Ono |
| A method for producing a hexenol glycoside using a hexenol glycosyltransferase. A transformant transformed with a gene encoding a hexenol glycosyltransferase and a method for preparing such a transformant. | ||||||
| 44 | USE OF PERTUSSIS TOXIN AS A THERAPEUTIC AGENT | US15782151 | 2017-10-12 | US20180028623A1 | 2018-02-01 | Jiong Shi |
| The present application relates to the use of pertussis toxin, and its derivatives, analogs, salts and pharmaceutical equivalents. In one embodiment, the invention provides a method of treating or preventing a neurological disease or injury by administering pertussis toxin to the individual. | ||||||
| 45 | ENZYMATIC SYNTHESIS OF SOLUBLE GLUCAN FIBER | US15313347 | 2015-05-22 | US20170218093A1 | 2017-08-03 | Qiong Cheng; Robert Dicosimo; Arthur Ouwehand; Zheng You; Mark S. Payne; Jian Ping Lai; Kristin Ruebling-Jass; Steven Cary Rothman |
| An enzymatically produced soluble α-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble α-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble α-glucan fiber are also provided. | ||||||
| 46 | GLYCOSYL TRANSFERASES AND THEIR USES | US15322376 | 2015-06-26 | US20170204380A1 | 2017-07-20 | Wilfried SCHWAB |
| The present invention relates to novel glycosyl transferases from Vitis vinifera that are capable of catalyzing the formation of certain glycosides with high efficiency, to nucleic acid molecules encoding such glycosyl transferases, to vectors, host cells and transgenic plants comprising nucleic acid sequences coding for such glycosyl transferases, and to methods for preparing and uses of such glycosyl transferases. | ||||||
| 47 | NOVEL GLYCOSYLTRANSFERASE GENE AND USE THEREOF | US15308117 | 2015-05-01 | US20170058269A1 | 2017-03-02 | Yoshikazu TANAKA; Naoko OKITSU; Keisuke MATSUI |
| Provided is a polynucleotide for encoding a protein that exhibits activity for transferring a sugar to a hydroxyl group at position 7 of a flavone, particularly flavone 4′-glucoside. A polynucleotide selected from the group consisting of: (a) polynucleotides comprising a base sequence of SEQ ID NO.: 1 or SEQ ID NO.: 5; (b) polynucleotides that hybridize, under stringent conditions, with polynucleotides comprising a base sequence complementary to a base sequence of SEQ ID NO.: 1 or SEQ ID NO.: 5, wherein the polynucleotides encode a protein that exhibits activity for transferring a sugar to a hydroxyl group at position 7 of a flavone; (c) polynucleotides for encoding proteins comprising an amino acid sequence of SEQ ID NO.: 2 or SEQ ID NO.: 6; (d) polynucleotides for encoding proteins comprising an amino acid sequence in which one or more amino acids have been deleted, substituted, inserted, and/or added in an amino acid sequence of SEQ ID NO.: 2 or SEQ ID NO.: 6, the polynucleotides exhibiting activity for transferring a sugar to a hydroxyl group at position 7 of a flavone; and the like. | ||||||
| 48 | GLYCOSYLTRANSFERASE GLYCOSYLATING FLAVOKERMESIC ACID AND/OR KERMESIC ACID | US15105673 | 2014-12-18 | US20160376569A1 | 2016-12-29 | Rubini Maya Kannangara; Mads Bennedsen; Bjon Madsen; Kim Binderup; Ulf Thrane; Rasmus John Normand Frandsen; Uffe Hasbro Mortensen; Birger Lindberg Moller; Finn Thyge Okkels |
| An isolated glycosyltransferase (GT) polypeptide capable of: (I): conjugating glucose to flavokermesic acid (FK); and/or (II): conjugating glucose to kermesic acid (KA) and use of this GT to e.g. make Carminic acid. | ||||||
| 49 | METHOD FOR USING HEXENOL GLYCOSYL TRANSFERASE | US14908889 | 2014-08-01 | US20160319317A1 | 2016-11-03 | Eiichiro ONO |
| The object of the present invention is to provide a method for producing a hexenol glycoside by means of hexenol glycosyltransferase.The present invention provides a method for producing a hexenol glycoside by means of hexenol glycosyltransferase. The present invention provides a transformant transformed with a gene for hexenol glycosyltransferase and a method for preparing such a transformant. | ||||||
| 50 | RECOMBINANT PRODUCTION OF STEVIOL GLYCOSIDES | US15032286 | 2014-10-03 | US20160251635A1 | 2016-09-01 | Guohong Mao; Xiaodan Yu |
| Recombinant polypeptides having UDP-glycosyltransferase activities, including a 1,2-19-O-glucose glycosylation activity and a 1,2-13-O-glucose glycosylation activity for synthesizing of steviol glucosides, are provided. A method of producing a steviol glycoside composition using such recombinant polypeptide is also provided. Also disclosed are steviol glycosides referred to as rebaudioside Z1 and rebaudioside Z2. | ||||||
| 51 | METHOD FOR PRODUCING MODIFIED RESVERATROL | US14915208 | 2014-08-15 | US20160215306A1 | 2016-07-28 | Richard Jan Steven Baerends; Ernesto Simon; Jean Phillippe Meyer; Carlos Casado Vazquez |
| Methods for producing glycosylated and methylated resveratrol in a genetically engineered cell, by bioconversion, and in vitro are disclosed herein. | ||||||
| 52 | Thermophilic and thermoacidophilic glycosylation genes and enzymes from Alicyclobacillus acidocaldarius and related organisms, methods | US12380450 | 2009-02-26 | US09234228B2 | 2016-01-12 | David N. Thompson; William A. Apel; Vicki S. Thompson; David W. Reed; Jeffrey A. Lacey |
| Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for glycosylating and/or post-translationally modifying proteins using isolated and/or purified polypeptides and nucleic acid sequences from Alicyclobacillus acidocaldarius. | ||||||
| 53 | Anthocyanins with Specific Properties | US14654291 | 2013-12-23 | US20150344920A1 | 2015-12-03 | Jorgen Hansen; Patricia Hoyle; Michael Naesby; Joseph M. Sheridan; Jonathan R. Heal |
| The present disclosure provides methods for identifying anthocyanins with improved stability, color, or hue using a screening method, and producing anthocyanins with improved stability, color, or hue in, for example, host cells comprising one or more heterologous glycosyltransferase nucleic acid molecules and one or more heterologous acyltransferase nucleic acid molecules. | ||||||
| 54 | TUMOR SPECIFIC OLIGOSACCHARIDE EPITOPES AND USE THEREOF | US14223346 | 2014-03-24 | US20140234318A1 | 2014-08-21 | Jari NATUNEN; Susann TENEBERG; Karl-Anders KARLSSON; Tero SATOMAA; Annamari HEISKANEN |
| The present invention describes oligosaccharide sequences, which are specifically expressed by human tumors. The present invention is related to a method of determining an oligosaccharide sequence, which comprises a tumor specific terminal N-acetylglucosamine residue, in a biological sample, the presence of said sequence in said sample being an indication of the presence of cancer. The present invention provides antigenic substances comprising said oligosaccharide sequences in a polyvalent form and it further provides diagnostic agents, pharmaceutical compositions and cancer vaccines comprising said oligosaccharide sequences or substances binding to said oligosaccharide sequences. The present invention is also related to methods for the treatment of cancer. | ||||||
| 55 | Transgenic plants with enhanced agronomic traits | US13299402 | 2011-11-18 | US08410336B2 | 2013-04-02 | Linda L. Lutfiyya |
| This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits. | ||||||
| 56 | TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS | US13676836 | 2012-11-14 | US20130074205A1 | 2013-03-21 | Savitha Madappa; Pranesh Badami; Dhanalakshmi Ramachandra; Sangeetha Singh; Vidya Kammaradi Ramanth Bhat; Stephen M. Duff; Steve S. He; Linda L. Lutfiyya; Tymagondlu V. Venkatesh |
| This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits. | ||||||
| 57 | Tumor specific oligosaccharide sequences and use thereof | US10487203 | 2002-08-20 | US08236487B2 | 2012-08-07 | Jari Natunen; Susann Teneberg; Karl-Anders Karlsson; Tero Satomaa; Annamari Heiskanen |
| The present invention describes oligosaccharide sequences, which are specifically expressed by human tumors. The present invention is related to a method of determining an oligosaccharide sequence, which comprises a tumor specific terminal N-acetylglucosamine residue, in a biological sample, the presence of said sequence in said sample being an indication of the presence of cancer. The present invention provides antigenic substances comprising said oligosaccharide sequences in a polyvalent form and it further provides diagnostic agents, pharmaceutical compositions and cancer vaccines comprising said oligosaccharide sequences or substances binding to said oligosaccharide sequences. The present invention is also related to methods for the treatment of cancer. | ||||||
| 58 | Tumor specific oligosaccharide sequences and use thereof | US10487203 | 2002-08-20 | US20050014718A1 | 2005-01-20 | Jari Natunen; Susann Teneberg; Karl-Anders Karlsson; Tero Satomaa; Annamari Heiskanen |
| The present invention describes oligosaccharide sequences, which are specifically expressed by human tumors. The present invention is related to a method of determining an oligosaccharide sequence, which comprises a tumor specific terminal N-acetylglucosamine residue, in a biological sample, the presence of said sequence in said sample being an indication of the presence of cancer. The present invention provides antigenic substances comprising said oligosaccharide sequences in a polyvalent form and it further provides diagnostic agents, pharmaceutical compositions and cancer vaccines comprising said oligosaccharide sequences or substances binding to said oligosaccharide sequences. The present invention is also related to methods for the treatment of cancer. | ||||||
| 59 | RECOMBINANT PRODUCTION OF STEVIOL GLYCOSIDES | EP14857965.9 | 2014-10-03 | EP3063286B1 | 2018-12-05 | MAO, Guohong; YU, Xiaodan |
| Recombinant polypeptides having UDP-glycosyltransferase activities, including a 1,2-19-O-glucose glycosylation activity and a 1,2-13-O-glucose glycosylation activity for synthesizing of steviol glucosides, are provided. A method of producing a steviol glycoside composition using such recombinant polypeptide is also provided. Also disclosed are steviol glycosides referred to as rebaudioside Z1 and rebaudioside Z2. | ||||||
| 60 | METHOD FOR USING HEXENOL GLYCOSYL TRANSFERASE | EP14831646 | 2014-08-01 | EP3042953A4 | 2017-07-12 | ONO EIICHIRO |
| The object of the present invention is to provide a method for producing a hexenol glycoside by means of hexenol glycosyltransferase. The present invention provides a method for producing a hexenol glycoside by means of hexenol glycosyltransferase. The present invention provides a transformant transformed with a gene for hexenol glycosyltransferase and a method for preparing such a transformant. | ||||||
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