| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 세포투과성 수송도메인 융합단백질과 그 용도 | KR1020030010750 | 2003-02-20 | KR1020040075236A | 2004-08-27 | 최수영; 박진서; 음원식; 김대원; 최진희 |
| PURPOSE: A cell-transducing transport domain fusion protein and use thereof are provided, thereby effectively transporting the transport domain fusion protein into a cell, and maintaining the activity of transferred protein within the cell, so that it can be useful for transferring bio-stimulating materials into the cells. CONSTITUTION: The cell-transducing transport domain fusion protein is prepared by covalently binding a transport domain comprising a hydrophobic domain consists of 15 to 30 amino acids and contains 5 or more of triptophanes, a lysine containing hydrophilic domain, and a spacer which separates these two domains to the N-terminal or C-terminal of a target protein which is not cell-transducible, wherein the transport domain is a peptide PEP-1 having the amino acid sequence set forth in SEQ ID NO:1. | ||||||
| 2 | 세포침투성 카탈라제 융합단백질 및 그 용도 | KR1020010014147 | 2001-03-19 | KR1020020074282A | 2002-09-30 | 최수영; 권혁일; 박진서; 강정훈; 원무호; 강태천; 이길수; 한규형 |
| PURPOSE: Provided are a cell-transducible catalase fusion protein and its use, thereby directly transducing human catalase into a cell in protein level and scavenging harmful reactive oxygen species in the cell. CONSTITUTION: The catalase fusion protein is manufactured by covalent bond of a protein tranducing domain(PTD) to a catalase, wherein the protein transducing domain is characterized by one selected from oligo arginine consisting of HIV-1 Tat(49-57), Tat(51-57), Tat(50-56), Tat(50-57), Tat(50-55) and 5-12 arginine residues, and oligopeptide consisting of 5-12 arginine or lysine residues. It has amino acid sequence of SEQ ID NO:4, 6 or 8. | ||||||
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