| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 枸杞谷胱甘肽还原酶及编码基因与应用 | CN201610224631.0 | 2016-04-08 | CN105734026A | 2016-07-06 | 季静; 马志刚; 王罡 |
| 本发明公开了一种枸杞谷胱甘肽还原酶及编码基因与应用，枸杞谷胱甘肽还原酶，是SEQ ID NO.1所示的氨基酸序列。枸杞谷胱甘肽还原酶编码基因，是SEQ ID NO.2所示的脱氧核苷酸序列。本发明的枸杞谷胱甘肽还原酶编码基因导入目的植物中，得到耐受镉离子能力高和耐盐能力高的转基因植物。 | ||||||
| 2 | 包含谷胱甘肽还原酶和氧化型谷胱甘肽的组合物，以及其治疗用途 | CN201180038381.7 | 2011-07-29 | CN103167877A | 2013-06-19 | 拉法埃莱·安索维尼 |
| 本发明涉及一种组合物，包含谷胱甘肽还原酶（GSSG-r）和氧化型谷胱甘肽（GSSG）或其药用盐，用于作为抗病毒剂和抗细菌剂的药物应用，以及用于保护以抵抗自由基特别是由细胞液辐解产生的自由基的毒性。 | ||||||
| 3 | 谷胱甘肽还原酶在结合青霉素类抗生素的应用 | CN201410821599.5 | 2014-12-25 | CN104560903A | 2015-04-29 | 彭宣宪; 李惠; 朱伟聪 |
| 本发明属于生物技术领域，具体公开了谷胱甘肽还原酶在结合青霉素类抗生素的应用。本发明谷胱甘肽还原酶的序列如SEQ ID NO:1所示。本发明发现谷胱甘肽还原酶ETAE_3367是一种新的青霉素类抗生素结合蛋白，可有效应用于青霉素类抗生素的检测、检测试剂的制备以及青霉素类抗生素作用和耐药机制的进一步研究。 | ||||||
| 4 | Compositions comprising glutathione reductase and oxidized glutathione | US13813426 | 2011-07-29 | US08852582B2 | 2014-10-07 | Raffaele Ansovini |
| Compositions comprising Glutathione Reductase (GSSG-r) and Oxidized Glutathione (GSSG) or pharmaceutically acceptable salts thereof for pharmaceutical use as antiviral and antibacterial agents and for the protection against the toxicity of free radicals and in particular radicals produced by the radiolysis of cellular water are provided. Methods of making and using such compositions are also provided. | ||||||
| 5 | COMPOSITIONS COMPRISING GLUTATHIONE REDUCTASE AND OXIDIZED GLUTATHIONE | US13813426 | 2011-07-29 | US20130216514A1 | 2013-08-22 | Raffaele Ansovini |
| Compositions comprising Glutathione Reductase (GSSG-r) and Oxidized Glutathione (GSSG) or pharmaceutically acceptable salts thereof for pharmaceutical use as antiviral and antibacterial agents and for the protection against the toxicity of free radicals and in particular radicals produced by the radiolysis of cellular water are provided. Methods of making and using such compositions are also provided. | ||||||
| 6 | 水素支援ジスルフィド酵素水素化分解によるメルカプタンの製造方法 | JP2018516703 | 2016-09-29 | JP2018529356A | 2018-10-11 | フレミ,ジョルジュ; マスラン,アルノー; ブラッセル,ユゴー |
| 本発明は、ジスルフィドおよび水素から、酵素触媒作用によりメルカプタンを製造する方法、特にジメチルジスルフィドおよび水素からメチルメルカプタンを製造する方法に関する。 | ||||||
| 7 | L−メチオニンの製造方法 | JP2018516708 | 2016-09-29 | JP2018529357A | 2018-10-11 | フレミ,ジョルジュ; マスラン,アルノー; ブラッセル,ユゴー |
| 本発明は、L−メチオニン前駆体であるジメチルジスルフィド(DMDS)と水素との酵素反応を行うことによってL−メチオニンを製造する方法に関する。 | ||||||
| 8 | METHOD FOR PRODUCING L-METHIONINE | US15764541 | 2016-09-29 | US20180282772A1 | 2018-10-04 | Georges FREMY; Arnaud MASSELIN; Hugo BRASSELET |
| Provided is an enzymatic process for preparing L-methionine from diethyl disulfide. | ||||||
| 9 | METHOD FOR PRODUCING GLUTATHIONE | US15555392 | 2016-03-04 | US20180044710A1 | 2018-02-15 | Kiyotaka HARA; Akihiko KONDO; Akira IWASAKI; Yuichi IWAMOTO |
| The present invention aims to provide a yeast that is genetically modified so as to more highly produce glutathione, and a method of producing glutathione utilizing the yeast. The present invention provides a method of producing glutathione, including culturing a yeast whose thiol oxidase activity is increased as compared to the parent strain in a culture medium to produce glutathione, and recovering glutathione from the cultured broth obtained. | ||||||
| 10 | Nonribosomal peptide synthetases | US14713662 | 2015-05-15 | US09487763B2 | 2016-11-08 | David H. Sherman; Michael Marie Kaufman-Schofield; Sunit Jain; Gregory Dick |
| The present disclosure is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS)-derived drug and analogs thereof. The invention provides polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS-derived drug, the polypeptides encoded by such polynucleotides, expression vectors comprising the polynucleotides, host cells comprising the polynucleotides or expression vectors, and kits comprising a host cell. Also provided is a method for the production of ET-743, the NRPS-derived drug. | ||||||
| 11 | Method of expressing proteins with disulfide bridges with enhanced yields and activity | US13127970 | 2009-11-12 | US08802394B2 | 2014-08-12 | Radu O. Minea; Stephen D. Swenson; Francis S. Markland, Jr. |
| Provided herein are methods for expressing proteins with disulfide bridges such as Vicrostatin (VCN), a chimeric variant of native snake venom disintegrin Contortrostatin (CN). The methods include what is believed to be a more efficient natural selection process that results in generating increased amounts of correctly-folded active conformers of proteins with disulfide bridges. In an aspect, this is achieved by growing Origami B cells in a more optimal redox environment during the induction of heterologous recombinant protein production. | ||||||
| 12 | METHOD OF EXPRESSING PROTEINS WITH DISULFIDE BRIDGES WITH ENHANCED YIELDS AND ACTIVITY | US13127970 | 2009-11-12 | US20110300579A1 | 2011-12-08 | Radu O. Minea; Stephen D. Swenson; Francis S. Markland, JR. |
| Provided herein are methods for expressing proteins with disulfide bridges such as Vicrostatin (VCN), a chimeric variant of native snake venom disintegrin Contortrostatin (CN). The methods include what is believed to be a more efficient natural selection process that results in generating increased amounts of correctly-folded active conformers of proteins with disulfide bridges. In an aspect, this is achieved by growing Origami B cells in a more optimal redox environment during the induction of heterologous recombinant protein production. | ||||||
| 13 | Glutathione reductase for therapy and prophylaxis of AIDS | US10863367 | 2004-06-09 | US20040223958A1 | 2004-11-11 | Raffaele Ansovini |
| The present invention concerns the use of glutathione-reductase (GSSG reductase) for the preparation of a medicament for the treatment of HIV-infected patients, seropositive or already affected by AIDS, both for prophylactic and therapeutic use. | ||||||
| 14 | L−メチオニンの製造方法 | JP2018516701 | 2016-09-29 | JP2018534919A | 2018-11-29 | フレミ,ジョルジュ; マスラン,アルノー |
| 本発明は、L−メチオニン前駆体であるジメチルジスルフィド(DMDS)と還元有機化合物との酵素反応を行うことによってL−メチオニンを製造する方法に関する。 | ||||||
| 15 | Use of gssg reductase for the treatment and prevention of Hiv-infected patients | JP2000619448 | 2000-03-28 | JP2003519088A | 2003-06-17 | アンソヴィーニ，ラファエル |
| (57)【要約】 本発明は、予防および治療の両方に使用するための、血清陽性であるか、または既にエイズに罹患しているＨＩＶ感染患者の処置のための医薬品を調製するための、グルタチオンレダクターゼ（ＧＳＳＧレダクターゼ）の使用に関する。 | ||||||
| 16 | METHOD FOR PRODUCING GLUTATHIONE | EP16759041 | 2016-03-04 | EP3266875A4 | 2018-07-25 | HARA KIYOTAKA; KONDO AKIHIKO; IWASAKI AKIRA; IWAMOTO YUICHI |
| The present invention aims to provide a yeast that is genetically modified so as to more highly produce glutathione, and a method of producing glutathione utilizing the yeast. The present invention provides a method of producing glutathione, including culturing a yeast whose thiol oxidase activity is increased as compared to the parent strain in a culture medium to produce glutathione, and recovering glutathione from the cultured broth obtained. | ||||||
| 17 | GLUTATHIONE REDUCTASE FOR THERAPY AND PROPHYLAXIS OF AIDS | EP00920596.4 | 2000-03-28 | EP1178819A2 | 2002-02-13 | Ansovini, Raffaele |
| The present invention concerns the use of glutathione-reductase (GSSG reductase) for the preparation of a medicament for the treatment of HIV-infected patients, seropositive or already affected by AIDS, both for prophylactic and therapeutic use. | ||||||
| 18 | METHOD FOR PRODUCING L-METHIONINE | US15763799 | 2016-09-29 | US20180291408A1 | 2018-10-11 | Georges FREMY; Arnaud MASSELIN |
| Provided is a process for the preparation of L-methionine in an enzymatic reaction utilizing dimethyl disulfide (DMDS) a precursor of L-methionine, and an organic reducing compound. In the process, methyl mercaptan can be formed by the enzymatic hydrogenolysis of the DMDS. | ||||||
| 19 | METHOD FOR PRODUCING MERCAPTANS BY HYDROGEN-ASSISTED DISULFIDE ENZYME HYDROGENOLYSIS | US15764189 | 2016-09-29 | US20180273991A1 | 2018-09-27 | Georges FREMY; Arnaud MASSELIN; Hugo BRASSELET |
| Provided is an enzymatic process for the preparation of a mercaptan of formula R—SH from disulfides utilizing hydrogen. | ||||||
| 20 | NONRIBOSOMAL PEPTIDE SYNTHETASES | US14713662 | 2015-05-15 | US20150361470A1 | 2015-12-17 | David H. Sherman; Michael Marie Kaufman-Schofield; Sunit Jain; Gregory Dick |
| The present disclosure is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS)-derived drug and analogs thereof. The invention provides polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS-derived drug, the polypeptides encoded by such polynucleotides, expression vectors comprising the polynucleotides, host cells comprising the polynucleotides or expression vectors, and kits comprising a host cell. Also provided is a method for the production of ET-743, the NRPS-derived drug. | ||||||
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