| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 预防头痛的组合物 | CN201380028125.9 | 2013-05-28 | CN104427983A | 2015-03-18 | O.索奧瓦尼伊米 |
| 本发明涉及一种用于口服给予的非毒性固体药用组合物，其包含一种或多种选自L-半胱氨酸、D-半胱氨酸和N-乙酰基半胱氨酸的半胱氨酸化合物，组合有一种或多种另外的活性剂，所述活性剂的至少一种选自胱氨酸、谷胱甘肽和甲硫氨酸，所述组合物还包含一种或多种药用添加剂。此外，本发明涉及一种减少严重头痛，特别是偏头痛和/或丛集性头痛的发生率的方法。 | ||||||
| 2 | 用于治疗或预防与高组胺水平相关的涉及疼痛增加的疾病的含二胺氧化酶的局部组合物 | CN201280013856.1 | 2012-03-15 | CN103476422A | 2013-12-25 | C·德鲁里乌; J·J·德鲁里乌 |
| 本发明涉及一种包含DAO的药物组合物、化妆品组合物或护肤品组合物，所述组合物用于治疗或预防与血液中高水平组胺相关的涉及疼痛增加的疾病或病理状况，其特征在于所述组合物的施用是局部的。 | ||||||
| 3 | 用于预防宿醉症状的含有二胺氧化酶的组合物 | CN201280013817.1 | 2012-03-16 | CN103429257A | 2013-12-04 | C·德鲁里乌; J·J·德鲁里乌 |
| 本发明涉及一种含有二胺氧化酶(DAO)的组合物，其用于预防由摄入酒精饮料产生的宿醉症状。 | ||||||
| 4 | 用于治疗或预防纤维肌痛或慢性疲劳综合症的含有二胺氧化酶的组合物 | CN201280013857.6 | 2012-03-16 | CN103476423A | 2013-12-25 | C·德鲁里乌; J·J·德鲁里乌 |
| 本发明涉及用于预防或治疗由纤维肌痛或慢性疲劳综合症所引起的症状和疾病的含二胺氧化酶的组合物。 | ||||||
| 5 | 含有二胺氧化酶的功能性食品及其用途 | CN201280013452.2 | 2012-03-15 | CN103442595A | 2013-12-11 | C·德鲁里乌; J·J·德鲁里乌 |
| 本发明涉及含DAO的功能性食品及其用于预防或治疗与血液中高水平的组胺相关的疾病或病理状况的用途，特别用于治疗或预防偏头痛、慢性疲劳、纤维肌痛、脊椎炎和由肌肉挛缩引起的疼痛的用途。 | ||||||
| 6 | 頭痛予防用組成物 | JP2015514547 | 2013-05-28 | JP2015518038A | 2015-06-25 | オスモ・スオヴァニエミ |
| 本発明は、L-システイン、D-システイン、およびN-アセチルシステインからなる群から選ばれる1またはそれ以上のシステイン化合物を、1またはそれ以上のさらなる活性物質と組み合わせて含み、その少なくとも1がシスチン、グルタチオン、およびメチオニンから選ばれ、さらに1またはそれ以上の医薬的添加物を含む、経口投与用の非毒性固体医薬組成物に関する。さらに、本発明は、重度の頭痛、特に片頭痛および/または群発性頭痛の発生を減少させる方法に関する。 | ||||||
| 7 | Composition for treating headaches | US14397563 | 2013-05-28 | US10092534B2 | 2018-10-09 | Osmo Suovaniemi |
| The present invention concerns a non-toxic solid pharmaceutical composition for oral administration, containing one or more cysteine compounds from the group of L-cysteine, D-cysteine and N-acetyl cysteine, combined with one or more additional active agents, at least one of which being selected from cystine, glutathione and methionine, the composition further containing one or more pharmaceutical additives. Further, the invention concerns a method for reducing the incidence of severe headaches, particularly migraine and/or cluster headaches. | ||||||
| 8 | COMPOSITION FOR PREVENTING HEADACHES | US14397563 | 2013-05-28 | US20150132275A1 | 2015-05-14 | Osmo Suovaniemi |
| The present invention concerns a non-toxic solid pharmaceutical composition for oral administration, containing one or more cysteine compounds from the group of L-cysteine, D-cysteine and N-acetyl cysteine, combined with one or more additional active agents, at least one of which being selected from cystine, glutathione and methionine, the composition further containing one or more pharmaceutical additives. Further, the invention concerns a method for reducing the incidence of severe headaches, particularly migraine and/or cluster headaches. | ||||||
| 9 | Oral Enzyme Compositions for Intestinal Delivery | US14110431 | 2012-04-05 | US20140212492A1 | 2014-07-31 | Mircea-Alexandru Mateescu; Carmen Calinescu; Pompilia Ispas-Szabo; Bruno Mondovi; Rodolfo Federico |
| The present disclosure describes compositions for intestinal delivery of enzyme formulations and methods of treating health problems with these formulations. More specifically, the enzyme formulations include at least one histaminase and various methods of treatment of physical conditions, such as inflammation, allergy, histamine intolerance, and intestinal cancer. | ||||||
| 10 | COMPOSITION COMPRISING DIAMINE OXIDASE FOR USE IN THE TREATMENT OR PREVENTION OF FIBROMYALGIA OR CHRONIC FATIGUE SYNDROME | US14005020 | 2012-03-16 | US20140004179A1 | 2014-01-02 | Carlos Duelo Riu; Juan José Duelo Riu |
| The present invention refers to a composition comprising diamine oxidase for use in the prevention or treatment of the symptoms and disorders caused by fibromyalgia or chronic fatigue syndrome. | ||||||
| 11 | Pharmaceutical preparation | US28011D | 1972-11-20 | USRE28011E | 1974-05-14 | |
| A PHARMACEUTICAL PREPARATION IS PROVIDED FOR THE TREATMENT OF HEMORRHOIDS, AND WHICH CONTAINS OXIDASE ENZYMES, SUCH AS MONOAMINE OXIDASE, OR DIAMINE OXIDASE, OR BOTH. THE OBJECT OF THE INVENTION IS TO DESTROY THE AMINES FROMED IN THE COLON BY BACTERIA. THE AMINES ARE DESTROYED BY THE OXIDIZING ACTION OF THE OXIDASES ON THE TISSUE AND BY THE PRODUCTION OF OXYGEN. THE OXYGEN IS PRODUCED, IN SOME INSTANCES, BY THE ACTION OF THE TISSUE ITSELF, OR A CATALASE ENZYME MAY BE ADDED TO THE PREPARATION WHICH DECOMPOSE THE HYDROGEN PEROXIDE WHICH IS PRESENT INTO WATER OXYGEN.
|
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| 12 | TOPICAL COMPOSITIONS COMPRISING DIAMINOOXIDASE FOR THE TREATMENT OR PREVENTION OF DISEASES ASSOCIATED WITH HIGH HISTAMINE LEVELS WHICH INVOLVE AN INCREASE IN PAIN | EP12711461.9 | 2012-03-15 | EP2686005A1 | 2014-01-22 | DUELO RIU, Carlos; DUELO RIU, Juan José |
| The present invention relates to a pharmaceutical, cosmetic or dermo-cosmetic composition that comprises DAO, for use in the prevention or treatment of diseases or pathological conditions associated with high levels of histamine in blood which involve an increase in pain, characterised in that the application of the composition is topical. | ||||||
| 13 | FUNCTIONAL FOODS COMPRISING DIAMINE OXIDASE AND USES THEREOF | US14005072 | 2012-03-15 | US20130344137A1 | 2013-12-26 | Carlos Duelo Riu; Juan José Duelo Riu |
| The present invention relates to functional foods comprising DAO and their use for the prevention or treatment of diseases or pathological conditions associated with high levels of histamine in blood, in particular for the prevention or treatment of migraine, chronic fatigue, fibromyalgia, spondylitis and pain caused by muscle contractures. | ||||||
| 14 | COMPOSITION COMPRISING DIAMINE OXIDASE FOR THE PREVENTION OF HANGOVER SYMPTOMS | US14005045 | 2012-03-16 | US20130344136A1 | 2013-12-26 | Carlos Duelo Riu; Juan José Duelo Riu |
| The present invention refers to a composition comprising diamine oxidase (DAO) for use in the prevention of hangover symptoms produced by the consumption of alcoholic drinks. | ||||||
| 15 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF COLITIS IN INFANTS | US16375776 | 2019-04-04 | US20190230970A1 | 2019-08-01 | Adam Hanna |
| This disclosure describes compositions and methods for preventing and/or treating necrotizing enterocolitis (NEC) and preventing loss of intestinal integrity and/or improving intestinal integrity in neonatal subjects. Compositions useful in the methods of the disclosure comprise diamine oxidase (DAO) which can be from any source and formulated for systemic administration. | ||||||
| 16 | Oral enzyme compositions for intestinal delivery | US14110431 | 2012-04-05 | US09878020B2 | 2018-01-30 | Mircea-Alexandru Mateescu; Carmen Calinescu; Pompilia Ispas-Szabo; Bruno Mondovi; Rodolfo Federico |
| The present disclosure describes compositions for intestinal delivery of enzyme formulations and methods of treating health problems with these formulations. More specifically, the enzyme formulations include at least one histaminase and various methods of treatment of physical conditions, such as inflammation, allergy, histamine intolerance, and intestinal cancer. | ||||||
| 17 | FUNCTIONAL FOODS COMPRISING DIAMINE OXIDASE AND USES THEREOF | US15488604 | 2017-04-17 | US20170224784A1 | 2017-08-10 | Carlos DUELO RIU; Juan José Duelo Riu |
| The present invention relates to functional foods comprising DAO and their use for the prevention or treatment of diseases or pathological conditions associated with high levels of histamine in blood, in particular for the prevention or treatment of migraine, chronic fatigue, fibromyalgia, spondylitis and pain caused by muscle contractures. | ||||||
| 18 | COMPOSITION COMPRISING DIAMINE OXIDASE FOR USE IN THE TREATMENT OR PREVENTION OF FIBROMYALGIA OR CHRONIC FATIGUE SYNDROME | US15283778 | 2016-10-03 | US20170020993A1 | 2017-01-26 | Carlos DUELO RIU; Juan José DUELO RIU |
| A composition includes diamine oxidase for use in prevention or treatment of symptoms and disorders caused by fibromyalgia or chronic fatigue syndrome. | ||||||
| 19 | Histaminase of vegetable origin for use in the treatment of allergic and septic shock and of allergic asthma | US12217447 | 2008-07-03 | US08722038B2 | 2014-05-13 | Bruno Mondovi′; Olivia Befani; Rodolfo Federico; Mircea Alexandru Mateescu; Emanuela Masini; Pier Francesco Mannaioni; Alfredo Vannacci |
| The present document describes a method of treating a histamine-mediated condition by administering an effective amount of a histaminase of vegetable origin to a subject in need. The histamine-mediated condition may be an allergic shock, septic shock, allergic asthma, anaphylaxis, rhinitis, allergic conjunctivitis, urticaria, atopic dermatitis, and pruritus. | ||||||
| 20 | Histaminase of vegetable origin for use in the treatment of allergic and septic shock and of allergic asthma | US12217447 | 2008-07-03 | US20080279840A1 | 2008-11-13 | Bruno Mondovi'; Olivia Befani; Rodolfo Federico; Mircea Alexandru Mateescu; Emanuela Masini; Pier Francesco Mannaioni; Alfredo Vannacci |
| A histaminase of vegetable origin to be used in the treatment of allergic and septic shock and in allergic asthma, and the preparation of the histaminase for pharmaceutical use and the corresponding pharmaceutical compositions. | ||||||
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