序号 专利名 申请号 申请日 公开(公告)号 公开(公告)日 发明人
1 Methods of regulating renalase (Monoamime Oxidase C) US11602409 2006-11-21 US20070248585A1 2007-10-25 Gary Desir; Jianchao Xu
The present invention provides methods of using Monoamine Oxidase C (MAO-C), also known as renalase, as a therapeutic protein in its active and inactive forms. Administering inactive renalase protein to individuals with lower renalase levels can be used to provide them with an adequate pool of the protein that can be activated by the body as needed. Active renalase protein can be administered to individuals needing an immediate reduction of catecholamine levels. An inhibitor of renalase may be used to enhance adrenergic action.
2 METHODS OF REGULATING RENALASE (MONOAMINE OXIDASE C) US12946630 2010-11-15 US20110081421A1 2011-04-07 GARY DESIR; JIANCHAO XU
The present invention provides methods of using Monoamine Oxidase C (MAO-C), also known as renalase, as a therapeutic protein in its active and inactive forms. Administering inactive renalase protein to individuals with lower renalase levels can be used to provide them with an adequate pool of the protein that can be activated by the body as needed. Active renalase protein can be administered to individuals needing an immediate reduction of catecholamine levels. An inhibitor of renalase may be used to enhance adrenergic action.
3 Methods of treatment with renalase (monoamine oxidase C) US11602409 2006-11-21 US07858084B2 2010-12-28 Gary Desir; Jianchao Xu
The present invention provides methods of using Monoamine Oxidase C (MAO-C), also known as renalase, as a therapeutic protein in its active and inactive forms. Administering inactive renalase protein to individuals with lower renalase levels can be used to provide them with an adequate pool of the protein that can be activated by the body as needed. Active renalase protein can be administered to individuals needing an immediate reduction of catecholamine levels. An inhibitor of renalase may be used to enhance adrenergic action.
4 Adjustment method of Renaraze (monoamine oxidase c) JP2008541423 2006-11-21 JP2009516693A 2009-04-23 シュ,ジアンチャオ; デジール,ゲイリー,ブイ.
本発明は、レナラーゼとしても公知であるモノアミンオキシダーゼC(MAO−C)の、治療的タンパク質としてのその活性および不活性形態での使用方法を提供する。 不活性型レナラーゼタンパク質のレナラーゼレベルの低い個体への投与を、必要に応じて身体により活性されることが可能であるタンパク質の適切なプールをこれらの個体に提供するために用いることが可能である。 活性レナラーゼタンパク質は、カテコールアミンレベルの即時の低下が必要である個体へ投与されることが可能である。 レナラーゼの阻害剤は、アドレナリン作用を増強するために用いられ得る。
5 METHODS OF REGULATING RENALASE (MONOAMINE OXIDASE C) EP06844468 2006-11-21 EP1951291A4 2012-04-04 DESIR GARY V; XU JIANCHAO
6 METHODS OF REGULATING RENALASE (MONOAMINE OXIDASE C) EP06844468.6 2006-11-21 EP1951291A1 2008-08-06 DESIR, Gary, V.; XU, Jianchao
The present invention provides methods of using Monoamine Oxidase C (MAO-C), also known as renalase, as a therapeutic protein in its active and inactive forms. Administering inactive renalase protein to individuals with lower renalase levels can be used to provide them with an adequate pool of the protein that can be activated by the body as needed. Active renalase protein can be administered to individuals needing an immediate reduction of catecholamine levels. An inhibitor of renalase may be used to enhance adrenergic action.
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