| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | Modified Glycine Oxidase | US14862323 | 2015-09-23 | US20160002610A1 | 2016-01-07 | Yuya Kodama; Wataru Hoshino; Kazutoshi Takahashi; Moemi Ito |
| The present invention provides a novel enzyme and methods of using the enzyme for measuring glycine concentration. Specifically, the present invention provides an enzyme in which at least one amino acid residue is mutated so as to improve a property of a glycine oxidase which is associated with the measurement of glycine (e.g., activity of glycine oxidase for glycine, thermal stability of glycine oxidase, and substrate specificity of glycine oxidase for glycine,); and a method of analyzing glycine, that includes measuring glycine contained in a test sample using the modified enzyme; and the like. | ||||||
| 2 | Modified glycine oxidase | US14862323 | 2015-09-23 | US09976126B2 | 2018-05-22 | Yuya Kodama; Wataru Hoshino; Kazutoshi Takahashi; Moemi Ito |
| The present invention provides a novel enzyme and methods of using the enzyme for measuring glycine concentration. Specifically, the present invention provides an enzyme in which at least one amino acid residue is mutated so as to improve a property of a glycine oxidase which is associated with the measurement of glycine (e.g., activity of glycine oxidase for glycine, thermal stability of glycine oxidase, and substrate specificity of glycine oxidase for glycine,); and a method of analyzing glycine, that includes measuring glycine contained in a test sample using the modified enzyme; and the like. | ||||||
| 3 | 改変グリシン酸化酵素 | JP2015508815 | 2014-03-28 | JP6350519B2 | 2018-07-04 | 小玉 優哉; 星野 亘; 高橋 一敏; 伊藤 萌美 |
| 4 | 改変グリシン酸化酵素 | JP2015508815 | 2014-03-28 | JPWO2014157705A1 | 2017-02-16 | 優哉 小玉; 亘 星野; 一敏 高橋; 萌美 伊藤 |
| 本発明は、グリシン濃度の測定に有用な手段および方法を提供する。具体的には、本発明は、グリシンの測定に関連するグリシン酸化酵素の特性(例、グリシンに対するグリシン酸化酵素の活性、グリシン酸化酵素の熱安定性、およびグリシンに対するグリシン酸化酵素の基質特異性)を改善するようにその少なくとも1つのアミノ酸残基を変異させた、改変酵素;ならびに当該改変酵素を用いて被検試料中に含まれるグリシンを測定することを含む、グリシンの分析方法などを提供する。 | ||||||
| 5 | MODIFIED GLYCINE OXIDASE | EP14773823 | 2014-03-28 | EP2980215A4 | 2016-11-30 | KODAMA YUYA; HOSHINO WATARU; TAKAHASHI KAZUTOSHI; ITO MOEMI |
| The present invention provides a means and method useful for measurement of a glycine concentration. Specifically, the present invention provides a modified enzyme in which at least one amino acid residue is mutated so as to improve a property of a glycine oxidase which is associated with the measurement of glycine (e.g., activity of glycine oxidase for glycine, thermal stability of glycine oxidase, and substrate specificity of glycine oxidase for glycine,); and a method of analyzing glycine, comprising measuring glycine contained in a test sample using the modified enzyme; and the like. | ||||||
| 6 | MODIFIED GLYCINE OXIDASE | EP14773823.1 | 2014-03-28 | EP2980215A1 | 2016-02-03 | KODAMA, Yuya; HOSHINO, Wataru; TAKAHASHI, Kazutoshi; ITO, Moemi |
The present invention provides a means and method useful for measurement of a glycine concentration. Specifically, the present invention provides a modified enzyme in which at least one amino acid residue is mutated so as to improve a property of a glycine oxidase which is associated with the measurement of glycine (e.g., activity of glycine oxidase for glycine, thermal stability of glycine oxidase, and substrate specificity of glycine oxidase for glycine,); and a method of analyzing glycine, comprising measuring glycine contained in a test sample using the modified enzyme; and the like. |
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| 7 | 변형된 글리신 옥시다제 | KR1020157026765 | 2014-03-28 | KR1020150135321A | 2015-12-02 | 고다마유야; 호시노와타루; 다카하시가즈토시; 이토모에미 |
| 본발명은글리신농도의측정에유용한수단및 방법을제공한다. 구체적으로, 본발명은, 글리신의측정과관련된글리신옥시다제의특성(예를들면, 글리신대한글리신옥시다제의활성, 글리신옥시다제의열 안정성및 글리신대한글리신옥시다제의기질특이성)을개선하도록적어도하나의아미노산잔기를돌연변이시킨, 변형된효소; 및상기변형된효소를사용하여시험샘플중에함유된글리신을측정함을포함하는, 글리신의분석방법등을제공한다. | ||||||
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