| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 用于增强甲醇存在下还原当量的可用性和产生相关的1,4-丁二醇的微生物和方法 | CN201380054008.X | 2013-08-27 | CN104736716A | 2015-06-24 | A·P·博加德; 罗宾·E·奥斯特豪特; S·J·万殿; 卡拉·安·特蕾西韦尔; 普里蒂·法克雅; 斯特凡·安德烈 |
| 本文提供了一种非天然存在的微生物生物体，其具有可以增强甲醇存在下还原当量的可用性的甲醇代谢途径(MMP)。所述还原当量可以用于增加由所述微生物生物体产生的例如1,4-丁二醇(BDO)等有机化合物的产物产率。本文中还提供了使用此类生物体产生BDO的方法。 | ||||||
| 2 | Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 1,4-butanediol related thereto | US13975678 | 2013-08-26 | US09657316B2 | 2017-05-23 | Anthony P. Burgard; Robin E. Osterhout; Stephen J. Van Dien; Cara Ann Tracewell; Priti Pharkya; Stefan Andrae |
| Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO. | ||||||
| 3 | MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING 1,4-BUTANEDIOL RELATED THERETO | US13975678 | 2013-08-26 | US20140058056A1 | 2014-02-27 | Anthony P. Burgard; Robin E. Osterhout; Stephen J. Van Dien; Cara Ann Tracewell; Priti Pharkya; Stefan Andrae |
| Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO. | ||||||
| 4 | MICROORGANISMS AND METHODS FOR THE PRODUCTION OF BUTADIENE USING ACETYL-COA | EP15818352.5 | 2015-07-02 | EP3167066A1 | 2017-05-17 | PHARKYA, Priti; BURGARD, Anthony P.; BURK, Mark J. |
| The invention provides non-naturally occurring microbial organisms containing butadiene or 2,4-pentadienoate pathways comprising at least one exogenous nucleic acid encoding a butadiene or 2,4-pentadienoate pathway enzyme expressed in a sufficient amount to produce butadiene or 2,4-pentadienoate. The organism can further contain a hydrogen synthesis pathway. The invention additionally provides methods of using such microbial organisms to produce butadiene or 2,4-pentadienoate by culturing a non-naturally occurring microbial organism containing butadiene or 2,4-pentadienoate pathways as described herein under conditions and for a sufficient period of time to produce butadiene or 2,4-pentadienoate. Hydrogen can be produced together with the production of butadiene or 2,4-pentadienoate. | ||||||
| 5 | SYNTHETIC METHANOTROPHIC AND METHYLOTROPHIC MICROORGANISMS | EP15780357 | 2015-04-14 | EP3132022A4 | 2017-12-13 | HELMAN NOAH; CLARKE ELIZABETH; GREENFIELD DEREK |
| Provided herein are non-naturally occurring microbial organisms comprising a methane-oxidizing metabolic pathway. The invention additionally comprises non-naturally occurring microbial organisms comprising pathways for the production of chemicals. The invention additionally provides methods for using said organisms for the production of chemicals. | ||||||
| 6 | MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING 1,4-BUTANEDIOL RELATED THERETO | US15488320 | 2017-04-14 | US20180030484A1 | 2018-02-01 | Anthony P. Burgard; Robin E. Osterhout; Stephen J. Van Dien; Cara Ann Tracewell; Priti Pharkya; Stefan Andrae |
| Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO. | ||||||
| 7 | SYNTHETIC METHANOTROPHIC AND METHYLOTROPHIC MICROORGANISMS | US15303518 | 2015-04-14 | US20170037438A1 | 2017-02-09 | Noah HELMAN; Elizabeth CLARKE; Derek GREENFIELD |
| Provided herein are non-naturally occurring microbial organisms comprising a methane-oxidizing metabolic pathway. The invention additionally comprises non-naturally occurring microbial organisms comprising pathways for the production of chemicals. The invention additionally provides methods for using said organisms for the production of chemicals. | ||||||
| 8 | MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING 1.4-BUTANEDIOL RELATED THERETO | US14424404 | 2013-08-27 | US20150203875A1 | 2015-07-23 | Anthony P. Burgard; Robin E. Osterhout; Stephen J. Van Dien; Cara Ann Tracewell; Priti Pharkya; Stefan Andrae |
| Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway (MMP) that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO. | ||||||
| 9 | MICROORGANISMS AND METHODS FOR THE PRODUCTION OF BUTADIENE USING ACETYL-COA | EP15818352 | 2015-07-02 | EP3167066A4 | 2018-03-07 | PHARKYA PRITI; BURGARD ANTHONY P; BURK MARK J |
| The invention provides non-naturally occurring microbial organisms containing butadiene or 2,4-pentadienoate pathways comprising at least one exogenous nucleic acid encoding a butadiene or 2,4-pentadienoate pathway enzyme expressed in a sufficient amount to produce butadiene or 2,4-pentadienoate. The organism can further contain a hydrogen synthesis pathway. The invention additionally provides methods of using such microbial organisms to produce butadiene or 2,4-pentadienoate by culturing a non-naturally occurring microbial organism containing butadiene or 2,4-pentadienoate pathways as described herein under conditions and for a sufficient period of time to produce butadiene or 2,4-pentadienoate. Hydrogen can be produced together with the production of butadiene or 2,4-pentadienoate. | ||||||
| 10 | SYNTHETIC METHANOTROPHIC AND METHYLOTROPHIC MICROORGANISMS | EP15780357.8 | 2015-04-14 | EP3132022A1 | 2017-02-22 | HELMAN, Noah; CLARKE, Elizabeth; GREENFIELD, Derek |
| Provided herein are non-naturally occurring microbial organisms comprising a methane-oxidizing metabolic pathway. The invention additionally comprises non-naturally occurring microbial organisms comprising pathways for the production of chemicals. The invention additionally provides methods for using said organisms for the production of chemicals. | ||||||
| 11 | MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING 1,4-BUTANEDIOL RELATED THERETO | EP13832246 | 2013-08-27 | EP2888369A4 | 2016-08-10 | BURGARD ANTHONY P; OSTERHOUT ROBIN E; VAN DIEN STEPHEN J; TRACEWELL CARA ANN; PHARKYA PRITI; ANDRAE STEFAN |
| Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO. | ||||||
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