| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | Method for dissolution testing of solid compositions containing digestive enzymes | US14237180 | 2012-08-08 | US09976171B2 | 2018-05-22 | Massimo Latino; Luigi Ghidorsi; Giovanni Ortenzi |
| The invention is directed to a process for measuring the amount of digestive enzymes released from a solid composition in a dissolution medium by fluorescence spectroscopy. The invention is also directed to a combined method for measuring both the dissolution and gastroresistance of a solid compositions comprising pancrelipase. | ||||||
| 2 | A MULTIGENE ASSAY | US15557776 | 2016-03-14 | US20180073083A1 | 2018-03-15 | Min-Han TAN; Puay Hoon TAN; Wai Jin TAN; Igor CIMA |
| An in vitro method of determining the type of a fibroepithelial tumour of the breast in a biological sample is provided. The method comprises the steps of obtaining an expression profile of one or more genes selected from the group consisting of PRAME, ADH1 B, CTHRC1, NPTX2, NEFL, ABCA8, DAPL1, TP63_v2, COL17A1, GCNT2, CCL19, MMP3, FN1, TRERF1, TRIM29, TESC, KIF20A, UHRF1, HEPACAM2, APOD, SERHL2. KIF15, HOXD13, GAGE2B, CALML5, C2orf40, ADH1C, CYP1B1, SPAG11B, GRB7, UBE2C, SYNGAP1, TP63_v1, LAMB1, OR5P3, SPC25, SHISA2, SCARA5, LHX2, RORC, DPYSL4, CH25H, and CHST1 in a sample and determining the differential activity of the one or more genes relative to a control; correlating the differential activity of the one or more genes relative to the control to obtain a p-score; and determining the type of fibroepithelial tumour based on the p-score, wherein a p-score of less than 0.5 is indicative of a fibroadenoma and a p-score of 0.5 and above is indicative of phyllodes tumour. Particularly, the said method is exemplified using an expression profile of five genes comprising of PRAME, FN1, CCL19, ABCA8 and APOD. A method for managing the treatment of a subject with a fibroepithelial tumour of the breast is also provided as well as a kit when used in the methods of the present invention. | ||||||
| 3 | METHOD FOR DISSOLUTION TESTING OF SOLID COMPOSITIONS CONTAINING DIGESTIVE ENZYMES | US14237180 | 2012-08-08 | US20140295474A1 | 2014-10-02 | Massimo Latino; Luigi Ghidorsi; Giovanni Ortenzi |
| The invention is directed to a process for measuring the amount of digestive enzymes released from a solid composition in a dissolution medium by fluorescence spectroscopy. The invention is also directed to a combined method for measuring both the dissolution and gastroresistance of a solid compositions comprising pancrelipase. | ||||||
| 4 | METHOD FOR DISSOLUTION TESTING OF SOLID COMPOSITIONS CONTAINING DIGESTIVE ENZYMES | EP12768900.8 | 2012-08-08 | EP2741766B1 | 2015-10-07 | LATINO, Massimo; GHIDORSI, Luigi; ORTENZI, Giovanni |
| The invention is directed to a process for measuring the amount of digestive enzymes released from a solid composition in a dissolution medium by fluorescence spectroscopy. The invention is also directed to a combined method for measuring both the dissolution and gastroresistance of a solid compositions comprising pancrelipase. | ||||||
| 5 | 消化酵素を含む組成物の溶出試験の方法 | JP2014524476 | 2012-08-08 | JP6004549B2 | 2016-10-12 | ラティーノ,マッシモ; ジドルシ,ルイージ; オルテンツィ,ジョヴァンニ |
| 6 | The method of dissolution test of the composition containing the digestive enzymes | JP2014524476 | 2012-08-08 | JP2014522991A | 2014-09-08 | ラティーノ，マッシモ; ジドルシ，ルイージ; オルテンツィ，ジョヴァンニ |
| 本発明は、固形組成物から溶出溶媒中に放出される消化酵素の量を蛍光分光法により測定する方法を対象とする。 本発明はさらに、パンクレリパーゼを含む固形組成物の溶出および腸溶性（ｇａｓｔｒｏｒｅｓｉｓｔａｎｃｅ）の両方を測定するための組み合わせた方法も対象とする。
【選択図】図４ａ |
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| 7 | METHOD FOR DISSOLUTION TESTING OF SOLID COMPOSITIONS CONTAINING DIGESTIVE ENZYMES | EP15178147.3 | 2012-08-08 | EP2987499A1 | 2016-02-24 | LATINO, Massimo; GHIDORSI, Luigi; ORTENZI, Giovanni |
The invention is directed to a process for measuring the amount of digestive enzymes released from a solid composition in a dissolution medium by fluorescence spectroscopy. The invention is also directed to a combined method for measuring both the dissolution and gastroresistance of a solid compositions comprising pancrelipase. |
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| 8 | METHOD FOR DISSOLUTION TESTING OF SOLID COMPOSITIONS CONTAINING DIGESTIVE ENZYMES | EP12768900.8 | 2012-08-08 | EP2741766A1 | 2014-06-18 | LATINO, Massimo; GHIDORSI, Luigi; ORTENZI, Giovanni |
| The invention is directed to a process for measuring the amount of digestive enzymes released from a solid composition in a dissolution medium by fluorescence spectroscopy. The invention is also directed to a combined method for measuring both the dissolution and gastroresistance of a solid compositions comprising pancrelipase. | ||||||
| 9 | 소화효소들을 함유하는 고형 조성물들의 용해 시험 방법 | KR1020147006147 | 2012-08-08 | KR1020140058617A | 2014-05-14 | 라티노,마시모; 오르텐지,지오반니; 기도르시,루이지 |
| 본 발명은 형광 분광법에 의해 용해 배지 내에서 고형 조성물로부터 방출된 소화 효소들의 양을 측정하는 방법에 관한 것이다. 본 발명은 또한 판크레리파아제를 포함하는 고형 조성물의 용해 및 위저항 둘 다를 측정하기 위한 결합된 방법에 관한 것이다.
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