| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 用于治疗肿瘤的组合物和方法 | CN200780027843.9 | 2007-07-25 | CN101495633B | 2015-01-07 | P·奥古斯特; W·J·黄; S·纳特森; S·利伯曼 |
| 本发明涉及用于治疗肿瘤的组合物，制备这种组合物的方法，以及使用这种组合物的方法。本发明还涉及一种用于检测核心蛋白1和/或线粒体呼吸复合体III的其他蛋白质活性的抑制剂的检测方法。 | ||||||
| 2 | 用于治疗肿瘤的组合物和方法 | CN200780027843.9 | 2007-07-25 | CN101495633A | 2009-07-29 | P·奥古斯特; W·J·黄; S·纳特森; S·利伯曼 |
| 本发明涉及用于治疗肿瘤的组合物，制备这种组合物的方法，以及使用这种组合物的方法。本发明还涉及一种用于检测核心蛋白1和/或线粒体呼吸复合体III的其他蛋白质活性的抑制剂的检测方法。 | ||||||
| 3 | 方法 | CN00809815.8 | 2000-04-26 | CN1359425A | 2002-07-17 | J·D·温达斯; S·P·赫尼; A·伦维克; D·M·怀特坎贝; S·利特勒; N·J·吉布森; J·特克; C·P·斯坦格尔 |
| 本发明公开了对于检测线粒体所编码基因(例如细胞色素b基因)中低频率突变特别灵敏的方法、使这些方法成为筛选用于产生杀真菌抗性植物致病真菌的特别有用并且在商业上重要的方法,其中所述抗性是由于线粒体所编码基因中的突变引起的。所公开的方法包括单核苷酸多态检测技术,特别是PCR检测方法。也公开了许多植物致病真菌的编码野生型和突变型细胞色素b序列部分的DNA序列以及应用所述序列信息检测导致杀真菌剂抗性的突变。也公开了等位基因特异性寡核苷酸和寡核苷酸探针、诊断性引物和诊断试剂盒。 | ||||||
| 4 | Compositions and methods for the treatment of tumors | JP2009521971 | 2007-07-25 | JP2009544731A | 2009-12-17 | スリダーラン・ナーテサン; ソイアン・リーバーマン; ポール・オーガスト; ワーン・イェン・フワーン |
| 本発明は、腫瘍の治療に有用である組成物、その様な組成物の製造方法、及びその様な組成物の使用方法に関する。 本発明は、また、Ｃｏｒｅ１タンパク質及び／又は他のミトコンドリア呼吸複合体ＩＩＩタンパク質の活性の阻害剤をアッセイする方法に関する。 | ||||||
| 5 | Respiratory chain enzyme genes of coryneform bacteria | EP01121110.9 | 2001-09-03 | EP1195433A3 | 2002-06-12 | Sone, Nobuhito |
A gene coding for aa3 subunit I is obtained from aCorynebacterium glutamicum chromosomal DNA library by hybridization utilizing a probe produced based on a sequence common to a wide range of heme-copper enzymes. A gene coding for subunit II and a gene coding for subunit III are obtained by hybridization using a probe produced by using primers prepared based on the N-terminus amino acid sequence of subunit II, which is determined by using purified cytochrome aa3, and an operon coding for cytochrome bcl complex existing downstream from the foregoing genes is further obtained. |
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| 6 | Method | JP2000615395 | 2000-04-26 | JP2002542803A | 2002-12-17 | ウィンダス，ジョン・デイヴィッド; ギブソン，ニール・ジェイムズ; スィアカー，ジェーン; スタンガー，キャロル・パトリシア; ヒーニー，スティーヴン・ポール; ホワイトクーム，デイヴィッド・マーク; リトル，スティーヴン; レンウィック，アナベル |
| (57)【要約】 本発明は、チトクロームｂ遺伝子のようにミトコンドリアのコード化遺伝子中の低頻度突然変異を検出する際の特に高感度な方法を公開して、これらの方法をミトコンドリアコード化遺伝子における突然変異に由来する真菌耐性が始まる植物病原性真菌の検査に特に有効で市販上重要な手段とする。 公開した当該方法は一本鎖ヌクレオチド多型検出手法、特にＰＣＲ検出方法を含んでいる。 また開示したのは植物病原性真菌の領域の野生型及び突然変異株チトクロームｂ配列のＤＮＡ配列コード化部分及び真菌耐性を生じる突然変異を検出する配列情報の利用である。 対立遺伝子特異的ヌクレオチド及びオリゴヌクレオチドプローブ、診断用プライマー及び診断キットも同様に開示した。 | ||||||
| 7 | Respiratory chain enzyme gene of corynebacterium | JP2000270283 | 2000-09-06 | JP2002078490A | 2002-03-19 | SONE NOBUFUMI |
| PROBLEM TO BE SOLVED: To provide a cytochrome aa3-type oxidase of a Corynebacterium, a cytochrome bc1 complex, and a gene encoding the enzyme. SOLUTION: A gene encoding aa3 subunit I is obtained from a Corynebacterium glutamicum chromosomal DNA library by hybridization using a probe made based on a sequence widely common in hem-copper oxidases, a gene encoding subunit II and a gene encoding subunit III are obtained by making a probe using a primer made based on the N-terminated amino acid sequence of the subunt II determined using a purified cytochrome aa3 followed by hybridization, and an operon encoding a cytochrome bc1 complex existing downstream of these subunits. COPYRIGHT: (C)2002,JPO | ||||||
| 8 | Glucose biofuel cell | US12944381 | 2010-11-11 | US09017884B2 | 2015-04-28 | Philippe Cinquin; Chantal Gondran; Fabien Giroud; Serge Cosnier |
| A biofuel cell intended to be immersed into a liquid medium containing a sugar and oxygen, wherein the anode includes an enzyme capable of catalyzing the oxidation of the sugar and a redox mediator of low redox potential capable of exchanging electrons with the anode enzyme and the cathode includes an enzyme capable of catalyzing the reduction of oxygen and a redox mediator of high redox potential capable of exchanging electrons with the cathode enzyme. Each of the anode and cathode electrodes is formed of a solid agglomerate of a conductive material mixed with the appropriate enzyme and redox mediator and is solid with an electrode wire. | ||||||
| 9 | COMPOSITIONS FOR CAUSING, ENHANCING, AND/OR EXPEDITING OXO-BIODEGRADATION OF ARTICLES AND METHODS OF PRODUCTION AND USE THEREOF | US14520022 | 2014-10-21 | US20150037865A1 | 2015-02-05 | Donald E. Weder |
| Kits and assemblies for causing, enhancing, and/or expediting consumption of an article by at least one biodegradative living organism are disclosed. The kits and assemblies include at least one additional living organism that enhances and/or expedites consumption of the article by the at least one biodegradative living organism. Methods of producing and using same are also provided. | ||||||
| 10 | ASSESSMENT OF OOCYTE COMPETENCE BY DETECTING SPSB2 AND/OR TP53I3 GENE EXPRESSION | US14351768 | 2012-10-15 | US20140315744A1 | 2014-10-23 | Dagan Wells; Pasquale Patrizio |
| Methods are provided for evaluating an oocyte for fertilization and implantation comprising analysis of gene expression in cumulus cells wherein the detected genes or polypeptides include at least SPSB2 and TP53I3. For example, methods are provided for determining whether a cumulus cell expresses, or does not express, one or more of a group of markers identified as differently expressed between cumulus cells associated with chromosomally normal oocytes and cumulus cells associated with chromosomally abnormal oocytes. Methods are provided for the detection of marker expression of differentially expressed genes at the RNA level, as well as at the protein level. | ||||||
| 11 | PTD-UQCRB FUSION POLYPEPTIDE, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING ISCHEMIC DISEASES, CONTAINING SAME | US13701492 | 2011-06-01 | US20130072432A1 | 2013-03-21 | Ho Jeong Kwon; Jung Hwa Chang |
| A PTD-UQCRB fusion polypeptide, and a pharmaceutical composition for preventing and treating ischemic diseases, containing the same. The PTD-UQCRB fusion polypeptide of the present invention very effectively passes through a cell membrane to induce angiogenesis and does not cause cytotoxicity, and is thus useful for preventing and treating ischemic diseases. | ||||||
| 12 | Composition and method for treatment of tumors | US12304818 | 2007-07-25 | US08329669B2 | 2012-12-11 | Paul August; Waan Jeng Huang; Sridaran Natesan; Soyan Lieberman |
| The present invention relates to a composition which is useful in the treatment of a tumor, a method for making such a composition, and a method for using such a composition. The invention relates also to a method for assaying for inhibitors of the activity of Core 1 protein and/or other proteins of the respiratory complex III of mitochondria. | ||||||
| 13 | GLUCOSE BIOFUEL CELL | US12944381 | 2010-11-11 | US20110250510A1 | 2011-10-13 | Philippe CINQUIN; Chantal GONDRAN; Fabien GIROUD; Serge COSNIER |
| A biofuel cell intended to be immersed into a liquid medium containing a sugar and oxygen, wherein the anode includes an enzyme capable of catalyzing the oxidation of the sugar and a redox mediator of low redox potential capable of exchanging electrons with the anode enzyme and the cathode includes an enzyme capable of catalyzing the reduction of oxygen and a redox mediator of high redox potential capable of exchanging electrons with the cathode enzyme. Each of the anode and cathode electrodes is formed of a solid agglomerate of a conductive material mixed with the appropriate enzyme and redox mediator and is solid with an electrode wire. | ||||||
| 14 | CHLAMYDOMONAS VIOLAXANTHIN DE-EPOXIDASE ENZYME AND ITS USES | US15625798 | 2017-06-16 | US20180057800A1 | 2018-03-01 | Krishna K. Niyogi; Zhirong Li; Rachel Dent; Graham Peers |
| This disclosure provides Chlamydomonas violaxanthin de-epoxidase (CVDE) gene, polypeptides, and variants thereof as well as host cells that are genetically modified to express a CVDE polypeptide or variant. The disclosure additionally provides methods of producing such a genetically modified host cell and methods of using the cells , e.g., to increase zeaxanthin production. | ||||||
| 15 | Compositions for Causing, Enhancing, and/or Expediting Oxo-Biodegradation of Articles and Methods of Production and Use Thereof | US15083802 | 2016-03-29 | US20160208107A1 | 2016-07-21 | Donald E. Weder |
| Methods of causing, enhancing, and/or expediting oxo-biodegradation of articles using agents of oxo-biodegradation are provided. | ||||||
| 16 | Respiratory chain enzyme genes of coryneform bacteria | US10895359 | 2004-07-21 | US20050143570A1 | 2005-06-30 | Nobuhito Sone |
| A gene coding for aa3 subunit I is obtained from a Corynebacterium glutamicum chromosomal DNA library by hybridization utilizing a probe produced based on a sequence common to a wide range of heme-copper enzymes. A gene coding for subunit II and a gene coding for subunit III are obtained by hybridization using a probe produced by using primers prepared based on the N-terminus amino acid sequence of subunit II, which is determined by using purified cytochrome aa3, and an operon coding for cytochrome bc1 complex existing downstream from the foregoing genes is further obtained. | ||||||
| 17 | Respiratory chain enzyme genes of coryneform bacteria | US09945825 | 2001-09-05 | US20020106669A1 | 2002-08-08 | Nobuhito Sone |
| A gene coding for aa3 subunit I is obtained from a Corynebacterium glutamicum chromosomal DNA library by hybridization utilizing a probe produced based on a sequence common to a wide range of heme-copper enzymes. A gene coding for subunit II and a gene coding for subunit III are obtained by hybridization using a probe produced by using primers prepared based on the N-terminus amino acid sequence of subunit II, which is determined by using purified cytochrome aa3, and an operon coding for cytochrome bc1 complex existing downstream from the foregoing genes is further obtained. | ||||||
| 18 | Phenol oxidizing enzymes | US09218702 | 1998-12-22 | US06426410B1 | 2002-07-30 | Huaming Wang |
| Disclosed herein are novel phenol oxidizing enzymes naturally-produced by strains of the species Stachybotrys which possess a pH optima in the alkaline range and which are useful in modifying the color associated with dyes and colored compounds, as well as in anti-dye transfer applications. Also disclosed herein are biologically-pure cultures of strains of the genus Stachybotrys, designated herein Stachybotrys parvispora MUCL 38996 and Stachybotrys chartarum MUCL 38898, which are capable of naturally-producing the novel phenol oxidizing enzymes. Disclosed herein is the amino acid and nucleic acid sequence for Stachybotrys phenol oxidizing enzymes as well as expression vectors and host cells comprising the nucleic acid. Disclosed herein are methods for producing the phenol oxidizing enzyme as well as methods for constructing expression hosts. | ||||||
| 19 | Biopile à glucose | EP11160991.3 | 2011-04-04 | EP2375481A1 | 2011-10-12 | Cinquin, Philippe; Gondran, Chantal; Giroud, Fabien; Cosnier, Serge |
L'invention concerne une biopile destinée à être immergée dans un milieu liquide contenant un sucre et de l'oxygène, dans laquelle l'anode comprend une enzyme apte à catalyser l'oxydation du sucre et un médiateur redox et la cathode comprend une enzyme apte à catalyser la réduction de l'oxygène et un médiateur redox. Chacune des électrodes d'anode et de cathode est constituée d'un agglomérat solide d'un matériau conducteur mélangé à l'enzyme et au médiateur redox appropriés, est solidaire d'un fil d'électrode et est entourée d'une membrane semi-perméable laissant passer l'oxygène et le glucose et ne laissant pas passer l'enzyme et le médiateur redox. |
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| 20 | NOVEL GENE RCS 06 | EP06706848.6 | 2006-02-10 | EP1846552A2 | 2007-10-24 | CHEVREUX, Bastien; MAYER, Anne, Françoise; MEURY,Anja; MOUNCEY, Nigel, John; SHINJOH, Masako |
| The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C. | ||||||
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