| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 181 | Regeneration and repair of neural tissue using postpartum-derived cells | US12429849 | 2009-04-24 | US08277796B2 | 2012-10-02 | Darin J. Messina; Sanjay Mistry; Alexander M. Harmon; Ian Ross Harris; Anthony J. Kihm; Agnieszka Seyda; Chin-Feng Yi; Anna Gosiewska |
| Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed. | ||||||
| 182 | SEPARATION OF CULTURED CELLS | US12645113 | 2009-12-22 | US20110151535A1 | 2011-06-23 | Masahiro Ueda |
| A first cell containing at least one magnetic particle is provided and a second cell is also provided. The second cell is cultured in the presence of the first cell. An alternating magnetic field is applied to the first cell. The alternating magnetic field at least partially separates the first cell from the second cell. | ||||||
| 183 | REGENERATION AND REPAIR OF NEURAL TISSUE USING POSTPARTUM-DERIVED CELLS | US12429849 | 2009-04-24 | US20100260843A1 | 2010-10-14 | Darin J. Messina; Sanjay Mistry; Alexander M. Harmon; Ian Ross Harris; Anthony J. Kihm; Agnieszka Seyda; Chin-Feng Yi; Anna Gosiewska |
| Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed. | ||||||
| 184 | Postpartum cells derived from umbilical cord tissue, and methods of making and using the same | US11481480 | 2006-07-06 | US20070009494A1 | 2007-01-11 | Sanjay Mistry; Anthony Kihm; Ian Harris; Alexander Harmon; Darin Messina; Agnieszka Seyda; Chin-Feng Yi; Anna Gosiewska |
| Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described. | ||||||
| 185 | Repair and regeneration of ocular tissue using postpartum-derived cells | US11317574 | 2005-12-23 | US20060234376A1 | 2006-10-19 | Sanjay Mistry; Darin Messina; Ian Harris; Alexander Harmon; Anthony Kihm; Agnieszka Seyda; Chin-Feng Yi; Anna Gosiewska |
| Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of ocular tissue using the postpartum-derived cells are also disclosed. | ||||||
| 186 | Postpartum-derived cells for use in treatment of disease of the heart and circulatory system | US11322372 | 2005-12-30 | US20060188983A1 | 2006-08-24 | Ian Harris; Alexander Harmon; Anthony Kihm; Darin Messina; Sanjay Mistry; Agnieszka Seyda; Chin-Feng Yi; Anna Gosiewska |
| Cells derived from postpartum tissue are disclosed along with methods for their therapeutic use in diseases of the heart or circulatory system are disclosed. Cells may be used therapeuticall in either differentiated or undifferentiated forms, in homogenous cultures, or as populations with other cells, and in conjunction with other bioactive factors. | ||||||
| 187 | Cartilage and bone repair and regeneration using postpartum-derived cells | US11322003 | 2005-12-29 | US20060154367A1 | 2006-07-13 | Anthony Kihm; Agnieszka Seyda; Sridevi Dhanaraj; Ziwei Wang; Alexander Harmon; Ian Harris; Darin Messina; Sanjay Mistry; Anna Gosiewska |
| Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions. | ||||||
| 188 | Treatment of osteochondral diseases using postpartum-derived cells and products thereof | US11315969 | 2005-12-22 | US20060154366A1 | 2006-07-13 | Laura Brown; Sridevi Dhanaraj; Agnieszka Seyda |
| Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products such as lysates related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions such as osteoarthritis. | ||||||
| 189 | Cartilage and bone repair and regeneration using postpartum-derived cells | US11321863 | 2005-12-29 | US20060153817A1 | 2006-07-13 | Anthony Kihm; Agnieszka Seyda; Alexander Harmon; Ian Harris; Darin Messina; Sanjay Mistry; Anna Gosiewska; Chin-Feng Yi |
| Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions. | ||||||
| 190 | Hair follicle mesenchymal stem cells and use thereof | US10516031 | 2003-01-22 | US20060088505A1 | 2006-04-27 | Rolf Hoffmann; Kevin McElwee |
| The present invention relates to a method for isolating hair follicle mesenchymal stem cells and to the use thereof for therapy and prophylaxis as well as for cosmetic treatments. | ||||||
| 191 | Regeneration and repair of neural tissue using postpartum-derived cells | US10877269 | 2004-06-25 | US20050032209A1 | 2005-02-10 | Darin Messina; Sanjay Mistry; Alexander Harmon; Ian Harris; Anthony Kihm; Agnieszka Seyda; Chin-Feng Yi; Anna Gosiewska |
| Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed. | ||||||
| 192 | CELL CULTURE METHOD AND CELL CULTURE KIT | EP12773566.0 | 2012-04-20 | EP2700707B1 | 2018-06-06 | YOSHIKAWA Yoshihiro; MORIKAWA Naomi; TOMII Ryo |
| [Object] To provide a means which is suitable for mass culture of adherent cells and which allows easy and safe collection of the cultured adherent cells. [Solution] A cell culture kit 10 has a culture bag 11 which is formed by shaping at least one sheet having flexibility, such a level of hydrophilicity that the culture of adherent cells can be achieved, and permeability into a bag shape and which is filled with a culture medium; a dissociation solution bag 12 which is filled with a dissociation solution containing a metal chelating agent or ornithine or a derivative thereof, and a solution sending circuit 13 which connects the culture bag 11 and the dissociation solution bag 12 to each other and can send the dissociation solution from the dissociation solution bag 12 to the culture bag 11. | ||||||
| 193 | MICRONIZED WHARTON'S JELLY | EP15796851 | 2015-05-21 | EP3146039A4 | 2017-11-29 | SPENCER RANDALL; SITH SOMALY |
| The present invention provides compositions and formulations of micronized Wharton's jelly having a controlled viscosity such that when delivered to the injured region of a subject, it remains substantially localized with little or no migration out of the injured region for the repair and/or regeneration thereof. Micronized Wharton's Jelly can be suspended in a pharmaceutically acceptable aqueous carrier, such as saline, sterile water, or any suitable buffer, to form a suspension or a gelatinous gel composition, or it can be in the form of a paste, suitable for delivery into the space adjacent the articular surface cartilage injured region of a subject. The micronized Wharton's jelly when employed at sufficient concentrations can be hydrated into a gel or paste and administered topically, or it can be injected into the body through the use of a needle and syringe. Accordingly, micronized Wharton's Jelly, compositions, or formulations thereof, can be delivered in a manner that is more convenient than Wharton's jelly that has not been micronized in accordance with the present invention. | ||||||
| 194 | POSTPARTUM CELLS DERIVED FROM PLACENTAL TISSUE, AND METHODS OF MAKING AND USING THE SAME | EP04777231.4 | 2004-06-25 | EP1641914B1 | 2016-07-20 | KIHM, Anthony, J.; HARRIS, Ian, Ross; MISTRY, Sanjay; HARMON, Alexander, M.; MESSINA, Darin, J.; SEYDA, Agnieszka; YI, Chin-Feng; GOSIEWSKA, Anna |
| Cells derived from postpartum tissue are disclosed along with methods for their therapeutic use in diseases of the heart or circulatory system are disclosed. Cells may be used therapeutically in either differentiated or undifferentiated forms, in homogenous cultures, or as populations with other cells, and in conjunction with other bioactive factors. | ||||||
| 195 | SOFT TISSUE REPAIR AND REGENERATION USING POSTPARTUM-DERIVED CELLS | EP04777286.8 | 2004-06-25 | EP1641917B1 | 2016-04-27 | HARMON, Alexander, M.; HARRIS, Ian, Ross; KIHM, Anthony, J.; MISTRY, Sanjay; MESSINA, Darin, J.; SEYDA, Agnieszka; YI, Chin-Feng; GOSIEWSKA, Anna |
| Cells derived from postpartum tissue are disclosed along with methods for their therapeutic use in diseases of the heart or circulatory system are disclosed. Cells may be used therapeutically in either differentiated or undifferentiated forms, in homogenous cultures, or as populations with other cells, and in conjunction with other bioactive factors. | ||||||
| 196 | POSTPARTUM CELLS DERIVED FROM UMBILICAL CORD TISSUE, AND METHODS OF MAKING AND USING THE SAME | EP04756395.2 | 2004-06-25 | EP1641913B1 | 2016-01-06 | MISTRY, Sanjay; KIHM, Anthony, J.; HARRIS, Ian, Ross; HARMON, Alexander, M.; MESSINA, Darin, J.; SEYDA, Agnieszka; YI, Chin-Feng; GOSIEWSKA, Anna |
| Cells derived from postpartum tissue are disclosed along with methods for their therapeutic use in diseases of the heart or circulatory system are disclosed. Cells may be used therapeutically in either differentiated or undifferentiated forms, in homogenous cultures, or as populations with other cells, and in conjunction with other bioactive factors. | ||||||
| 197 | Cells derived from post-partum umbilical cord for use in treatment of disease of the heart and circulatory system | EP10183053.7 | 2004-06-25 | EP2399990B1 | 2015-07-22 | Harris, Ian Ross; Harmon, Alexander M.; Kihm, Anthony J.; Messina, Darin J.; Mistry, Sanjay; Seyda, Agnieszka; Yi, Chin-Feng; Gosiewska, Anna |
| Cells derived from postpartum tissue are disclosed along with methods for their therapeutic use in diseases of the heart or circulatory system are disclosed. Cells may be used therapeutically in either differentiated or undifferentiated forms, in homogenous cultures, or as populations with other cells, and in conjunction with other bioactive factors. | ||||||
| 198 | Repair and regeneration of ocular tissue using postpartum umbilical cord-derived cells | EP10184221.9 | 2004-06-25 | EP2338981B1 | 2015-04-22 | Mistry, Sanjay; Messina, Darin J.; Harris, Ian Ross; Harmon, Alexander M.; Kihm, Anthony J.; Seyda, Agnieszka; Yi, Chin-Feng; Gosiewska, Anna |
| Cells derived from postpartum tissue are disclosed along with methods for their therapeutic use in diseases of the heart or circulatory system are disclosed. Cells may be used therapeutically in either differentiated or undifferentiated forms, in homogenous cultures, or as populations with other cells, and in conjunction with other bioactive factors. | ||||||
| 199 | CELL CULTURE METHOD AND CELL CULTURE KIT | EP12773566 | 2012-04-20 | EP2700707A4 | 2014-12-03 | YOSHIKAWA YOSHIHIRO; MORIKAWA NAOMI; TOMII RYO |
| [Object] To provide a means which is suitable for mass culture of adherent cells and which allows easy and safe collection of the cultured adherent cells. [Solution] A cell culture kit 10 has a culture bag 11 which is formed by shaping at least one sheet having flexibility, such a level of hydrophilicity that the culture of adherent cells can be achieved, and permeability into a bag shape and which is filled with a culture medium; a dissociation solution bag 12 which is filled with a dissociation solution containing a metal chelating agent or ornithine or a derivative thereof, and a solution sending circuit 13 which connects the culture bag 11 and the dissociation solution bag 12 to each other and can send the dissociation solution from the dissociation solution bag 12 to the culture bag 11. | ||||||
| 200 | NOVEL METHODS AND CULTURE MEDIA FOR CULTURING PLURIPOTENT STEM CELLS | EP11770876.8 | 2011-09-07 | EP2614141A2 | 2013-07-17 | AMIT, Michal; ITSKOVITZ-ELDOR, Joseph |
| Provided is an isolated population of human pluripotent stem cells comprising at least 50% human pluripotent stem cells characterized by an OCT4+/TRA1-60−/TRA1-81−/SSEA1+/SSEA4− expression signature, and novel methods of generating and maintaining same in a pluripotent, undifferentiated state a suspension culture devoid of cell clumps. Also provided are novel culture media, cell cultures and methods for culturing pluripotent stem cells in a suspension culture or a two-dimensional culture system while maintaining the cells in a proliferative, pluripotent and undifferentiated state. The novel culture media comprise interleukin 11 (IL11) and Ciliary Neurotrophic Factor (CNTF); bFGF at a concentration of at least 50 ng/ml and an IL6RIL6 chimera; or an animal contaminant-free serum replacement and an IL6RIL6 chimera. Also provided are methods for generating lineage-specific cells from the pluripotent stem cells. | ||||||
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