The invention relates to the improvement of endonuclease-based antimicrobials by blocking DNA repair of double-strand break(s) (DSB(s)) in prokaryotic cells. In this respect, the invention especially concerns a method involving blocking DNA repair after a nucleic acid has been submitted to DSB, in particular by a Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) associated programmable double-strand endonuclease. The invention particularly relates to the use of an exogenous molecule that inhibits DNA repair, preferably a protein that binds to the ends of the double-stranded break to block DSB repair. The invention also relates to vectors, particularly phagemids and plasmids, comprising nucleic acids encoding nucleases and Gam proteins, and a pharmaceutical composition and a product containing these vectors and their application.

The invention described herein provides compositions and methods for treating preventing Helicobacter pylori infection.

The present invention relates to new antimicrobial polypeptides, nucleic acids encoding them, as well as recombinant vectors, host cells, antibodies, uses and methods relating thereto.

The disclosure provides methods and compositions useful for treating microbial and viral infections. In certain aspects, the compositions and methods relate to the use of an effective amount of a delta-haemolysin and/or phenol soluble modulin-delta or functional variant thereof. In other aspects, the compositions and methods relate to the use of an effective amount of Staphylococcus epidermidis or an extract of 5. epidermidis comprising delta-haemolysin and/or phenol soluble modulin-delta or functional variant thereof.

The invention describes a process for making compound (2), comprising the step of cyclising diene (3). Compound (2) may be aigialomycin D or a derivative thereof or may be elaborated to make aigialomycin D or derivative thereof. Furthermore compound (2) or derivative thereof can be used in treating cancer or malaria or a microbial infection.

　天然物由来で広範囲な抗菌スペクトルを有する、より強力な新規の抗菌活性物質を提供することを目的とし、次の工程（ａ）～（ｄ） （ａ）バチルス・ズブチルス（Bacillus　subtilis）を培養し、 　（ｂ）得られた培養物から上清を回収し、 　（ｃ）上清のｐＨを３以下に調整して生じた沈殿物を回収し、 　（ｄ）沈殿物からエタノールで抽出する を含む製造方法により得られる抗菌活性物質ＤＭ０５０７を提供する。  

A non-continuous immunoassay device which includes two or more separated pads for immunoassay analysis, and is capable of controlling the migration speed of a mobile phase between the separated pads, and an immunoassay method using the same are disclosed. The immunoassay device includes a first pad including a sample pad for receiving a liquid sample; a second pad which is spatially separated from the first pad by a predetermined distance, and to which the liquid sample migrates; an upper case for covering the upper parts of the first pad and the second pad; a lower case for covering the lower parts of the first pad and the second pad; and a connecting member which is formed on at least one of the upper case and the lower case, and located between the first pad and the second pad to form a passage for moving the liquid sample.