子分类：
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 181 | Novel benzoic acid derivative, medicine and manufacture | JP9500686 | 1986-04-25 | JPS6242947A | 1987-02-24 | UERUNERU FUOORENBERUKU; OSUUARUTO TSUIMUMERU; GERIITO ROTSUSHIEN; ERUUIN KIIZEUETSUTERU; URURITSUHI ZAIIPU |
| 182 | JPS624385B2 - | JP5062775 | 1975-04-25 | JPS624385B2 | 1987-01-30 | DEIITERU BORUMAN; URUFU MERUKERU; ROOMAN MUSHAUETSUKU; DEIITERU MANIA |
| 1504505 Sulphonamides HOECHST AG 25 April 1975 [25 April 1974 27 Dec 1974] 17337/75 Heading C2C The invention comprises novel compounds (I) (including salts thereof) in which R<SP>1</SP> and R<SP>2</SP>, which may be identical or different, each represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms, and, if R<SP>1</SP> represents a hydrogen atom, R<SP>2</SP> may also represent an alkoxymethyl group having from 1 to 4 carbon atoms in the alkoxy radical, a phenoxymethyl group or a phenylthiomethyl group, R<SP>3</SP> represents a hydrogen atom, a straight or branched chain alkyl group having from 1 to 4 carbon atoms, a cycloalkyl group, having 5 or 6 ring members, one of which may be replaced by an oxygen or sulphur atom, a phenyl or benzyl group which may be substituted in the phenyl nucleus by one or more substituents selected from nitro groups, alkyl groups having from 1 to 3 carbon atoms, alkoxy groups having from 1 to 5 carbon atoms and halogen atoms, or represents a benzhydryl group or an alkanoyloxymethyl group having 2 to 4 carbon atoms in the alkanoyl part, X represents a halogen atom, a CF 3 or CCl 3 group, a straight or branched chain, saturated or unsaturated alkyl group having from 1 to 6 carbon atoms, a benzyl group which may be substituted in the phenyl nucleus by one or more substituents selected from halogen atoms, hydroxy and amino groups, and alkyl and alkoxy groups, or represents one of the groups -O-R<SP>4</SP>, -S-R<SP>4</SP>, SO-R<SP>4</SP>, SO 2 -R<SP>4</SP> and NR<SP>4</SP>R<SP>5</SP>, in which R<SP>4</SP> represents a phenyl group which may be substituted by one or more substituents selected from halogen atoms, CF 3 , OH and amino groups, alkyl and alkoxy groups having from 1 to 4 carbon atoms, and SO 2 NH 2 groups, or represents a straight or branched chain alkyl group having from 1 to 4 carbon atoms which may be substituted by a phenyl, pyridyl, furyl or thienyl group, and R<SP>5</SP> represents a hydrogen atom, a straight or branched chain alkyl group having from 1 to 4 carbon atoms, and the group NR<SP>4</SP>R<SP>5</SP> may represent a saturated, heterocyclic, 5- or 6-membered ring which may be interrupted by an O-, N- or S- atom, A represents a single bond, or an alkylene chain of 1 to 3 carbon atoms which may be unsaturated, interrupted by O-, N- or S-atoms or substituted by halogen atoms and/or substituted by alkyl, aralkyl, aryl groups or by mono-nuclear hetero-aromatic rings, or A represents an ortho-phenylene radical or the grouping in which Y represents a single bond or an alkylene group having from 1 to 4 carbon atoms, and R<SP>6</SP> and R<SP>7</SP>, which may be identical or different, each represents a hydrogen or halogen atom or an alkyl group having from 1 to 4 carbon atoms. They are made by standard methods. Pharmaceutical preparations having diuretic and saluretic action contain (I) as active ingredient. Administration is enterally or parenterally. | ||||||
| 183 | Production of organic conductive complex | JP13983185 | 1985-06-26 | JPS62467A | 1987-01-06 | TANAKA MIKIAKI; URANO FUMIYOSHI; NAKAHATA MASAAKI; NAGOYA MAMORU |
| PURPOSE: To obtain an organic conductive complex, by reacting two or more different nitrogen-containing heterocyclic compound iodides with 7,7,8,8- tetracyanoquinodimethane in a specific organic solvent under a specific condition and precipitating crystal. CONSTITUTION: 3 Total mols of iodides of two or more different nitrogen- containing heterocyclic compound cations selected from isoquinoline derivative, quinoline derivative, pyridine derivative, etc., are reacted with 4 mols of a 7,7,8,8-tetracyanoquinodimethane (TCNQ) shown by the formula I (R and R' are H or lower alkyl) in an organic solvent (acetonitrile, etc.) to dissolve both of them, capable of recrystallizing at least one complex under heating and crystal of a reaction product [novel organic conductive complex having a donor part and an acceptor part shown by the formula II (x=0.1W0.9)] is precipitated in the solvent. COPYRIGHT: (C)1987,JPO&Japio | ||||||
| 184 | Dealkylation of amine | JP9196786 | 1986-04-21 | JPS61249955A | 1986-11-07 | UIRIAMU HARORUDO MIRAA; TERII MATSUKU BARUSAZAA |
| 185 | JPS616804B2 - | JP6303277 | 1977-05-30 | JPS616804B2 | 1986-03-01 | ONODA TAKESHI; WADA HIROSUKE; SATO KEIICHI; KASORI YUKIO |
| 186 | Amidine derivative and cardiotonic agent containing the same | JP23771583 | 1983-12-16 | JPS60130561A | 1985-07-12 | FUJII SETSUO; SATOU TAKUO; KAWAMURA HIROYUKI; YAEGASHI TAKASHI; KURUMI MASATERU; AOYAMA TAKUO |
| NEW MATERIAL:The compound of formula I [R1 and R2 are H, lower alkyl, etc.; X is group of formula II (R8 is H, lower alkyl, etc.; Z is single bond, -CH2-, -CH=CH-, etc.); R3 is H, Cl, methoxy, etc.; Y is -CH2CH2-, -CH=CH-, etc.; R4 is H, methoxy, benzoyl, etc.; R5-R7 are H, lower alkyl, amino, etc.]. EXAMPLE:4-{2-[4-(1-Phthalimidoethyl)phenyl]ethyl}benzamidine hydrochloride. USE:A cardiotonic agent having excellent activity to promote the myocardial contraction without increasing the pulse rate. It is useful as a remedy for cardiac insufficiency. PREPARATION:The compound of formula I can be produced by (1) reacting the xylene dihalide of formula III with the cyanophenol compound of formula IV, (2) reacting the reaction product with an amine compound, (3) adding an alcohol to the resultant compound of formula V in the presence of hydrogen chloride, and (4) condensing the reaction product with an amine compound. | ||||||
| 187 | JPS6010027B2 - | JP25576 | 1976-01-01 | JPS6010027B2 | 1985-03-14 | OKAMOTO AKYOSHI; KIKUMOTO RYOJI; TAMAO YOSHIKUNI; OOKUBO KAZUO; TEZUKA TOORU; TONOMURA SHINJI; HIJIKATA AKIKO |
| 188 | JPS5939424B2 - | JP2676875 | 1975-03-05 | JPS5939424B2 | 1984-09-22 | OKAMOTO AKYOSHI; KIKUMOTO RYOJI; TAMAO YOSHIKUNI; TONOMURA SHINJI; OOKUBO KAZUO; TEZUKA TOORU; HIJIKATA AKIKO |
| 189 | JPS5913504B2 - | JP24176 | 1976-01-01 | JPS5913504B2 | 1984-03-30 | OKAMOTO AKYOSHI; KIKUMOTO RYOJI; TAMAO YOSHIKUNI; OOKUBO KAZUO; TEZUKA TOORU; TONOMURA SHINJI; HIJIKATA AKIKO |
| 190 | JPS5913501B2 - | JP11024275 | 1975-09-11 | JPS5913501B2 | 1984-03-30 | OKAMOTO AKYOSHI; KIKUMOTO RYOJI; TAMAO YOSHIKUNI; OOKUBO KAZUO; TEZUKA TOORU; TONOMURA SHINJI; HIJIKATA AKIKO |
| 191 | Catalyst for preparation of morpholine | JP10840082 | 1982-06-25 | JPS58225078A | 1983-12-27 | SUMINO YUKIO; WATANABE FUMIO; NAKAI TAKAHIKO; KANEKO SHIZUO |
| PURPOSE: To provide a novel catalyst for the synthesis of morpholine, having high activity and selectivity, and excellent durability, by supporting nickel, copper, chromium and rhenium at specific atomic ratios on an α-alumina carrier. CONSTITUTION: A novel catalyst for the synthesis of morpholine of formula IIby the reaction of diethylene glycol of formula I with ammonia in the presence of hydrogen, is composed of nickel, copper, chromium, and rhenium supported on an α-alumina carrier. The amount of Ni is 2W20wt% based on α- alumina, and the atomic ratios of Ni:Cu, Ni:Cr and Ni:Re are 1:(0.4W0.02), 1:(0.5W0.05) and 1:(0.3W0.01), respectively. The catalyst can be prepared by dissolving the compounds of the above metals in an aqueous medium, immersing an α-alumina carrier in said solution, drying at 50W150°C, and reducing with hydrogen at 200W450°C. It has high activity and selectivity for the morpholine preparation reaction 1 and 2, and the activity, etc. can be maintained for a long period. COPYRIGHT: (C)1983,JPO&Japio | ||||||
| 192 | JPS5758342B2 - | JP300374 | 1973-12-27 | JPS5758342B2 | 1982-12-09 | YOKOBE TETSUO; ARAI TOMIO; ABE YUKIO |
| 193 | Chemical compounds | JP8258082 | 1982-05-18 | JPS57193427A | 1982-11-27 | ARUDO ANTONIO ARUJIERII; RONII REI KURENSHIYOU |
| 194 | Substituted 2,4-dialkoxybenzene sulfohalides, manufacture and use | JP6856782 | 1982-04-23 | JPS57181051A | 1982-11-08 | JIYANNPOORU FURUNIE; PATORITSUKU SHIYOAI |
| 195 | JPS5720293B2 - | JP1546073 | 1973-02-07 | JPS5720293B2 | 1982-04-27 | |
| 196 | Piperazine derivative | JP4644380 | 1980-04-08 | JPS56142262A | 1981-11-06 | MATSUMURA SHINGO; ENOMOTO HIROSHI; AOYANAGI YOSHIAKI; TANAKA HARUO |
| NEW MATERIAL:An N 4-carbamoylpiperazinopropanol derivative expressed by formula I [R is formula II [R 1 is ≤6C alkyl and cycloalkyl, etc. which may have an unsaturated bond; R 2 is H or CH 3; Z is -CH 2CH 2NHCO 2R 3 (R 3 is ≤4C lower alkyl), -NHSO 2R 3, etc.], formula III (n is 1W2), formula IV, etc.] and an acid addition salt thereof. USE: A β-blocking agent, capable of inhibiting the nervous transmission by the antagonism of the sympathetic peripheral β-acceptor, and usable for various circulatory diseases, e.g. hypertension, angina pectoris or arrhythmia, and diseases, e.g. lipid metaboilc disorder, with low toxicity. PROCESS: An aryl glycidyl ether, e.g. 3-(6-bromothiochroman-4-ylideneoxido)-1,2- epoxypropane, is reacted with N-carbamoylpiperazine in an unreactive solvent, e.g. an alcohol, to give the compound of formula I. COPYRIGHT: (C)1981,JPO&Japio | ||||||
| 197 | JPS5531191B2 - | JP2092278 | 1978-02-27 | JPS5531191B2 | 1980-08-16 | |
| 198 | JPS5527913B2 - | JP5993676 | 1976-05-26 | JPS5527913B2 | 1980-07-24 | |
| 199 | JPS5527912B2 - | JP5993576 | 1976-05-26 | JPS5527912B2 | 1980-07-24 | |
| 200 | JPS5441596B2 - | JP13784775 | 1975-11-18 | JPS5441596B2 | 1979-12-08 | |
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