| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 101 | Phenoxybenzoic acid compounds and herbicidal and plant growth regulant compositions | US404948 | 1982-08-04 | US4889946A | 1989-12-26 | Heinz Forster; Ludwig Eue; Robert R. Schmidt; Klaus Lurssen |
| Novel phenoxybenzoic acid derivatives of the general formula ##STR1## in which R.sup.1 and R.sup.2, independently of one another, each represent hydrogen or methyl,n represents zero or 1,x represents hydrogen or chlorine,y represents oxygen, sulphur, imino (NH) or alkylimino (N-alkyl) andz has the meaning given in the specification,a process for the preparation of the novel compounds and their use as herbicides and plant growth regulators. | ||||||
| 102 | Furazanylurea acaricides | US269263 | 1988-11-09 | US4886823A | 1989-12-12 | Wilhelm Sirrenberg; Albrecht Marhold; Ulrike Wachendorff-Neumann |
| Acaricidal 1-arylfurazanyl-3-(2-alkyl-4-halogenoalkoxyphenyl)-(thio)ureas of the formula ##STR1## in which Q stands for oxygen or sulphur,R.sup.1 stands for hydrogen, halogen, alkyl, halogenoalkyl, alkoxy, halogenoalkoxy, alkylthio or halogenoalkylthio, andR.sup.2 stands for hydrogen, halogen, alkyl or alkoxy, orR.sup.1 and R.sup.2 together stand for alkylenedioxy which is optionally substituted by halogen,R.sup.3 stands for alkyl andR.sup.4 stands for alkyl which is substituted by fluorine and optionally in addition by chlorine and/or bromine.The corresponding isocyanates of the formula ##STR2## are also new. | ||||||
| 103 | Diselenobis-benzoic acid amides of primary and secondary amines and processes for the treatment of diseases in humans caused by a cell injury | US253955 | 1988-10-03 | US4873350A | 1989-10-10 | Andre Welter; Harmut Fischer; Leon Christiaens; Albrecht Wendel; Eugen Etschenberg; Norbert Dereu; Peter Kuhl; Eric Graf |
| The present invention relates to new diselenobis-benzoic acid amides of primary and secondary amines of the general formula (I): ##STR1## and processes for the treatment of diseases in humans caused by a cell injury. | ||||||
| 104 | Herbicidal sulfonylureas | US252022 | 1988-09-28 | US4833252A | 1989-05-23 | Werner Topfl; Georg Pissiotas |
| Substituted N-phenylsulfonyl-N'-pyrimidinylureas and N-phenylsulfonyl-N'-triazinylureas of the general formula ##STR1## and the salts thereof with amines, alkali metal bases or alkaline earth metal bases, or with quaternary ammonium bases, have good pre- and postemergence selective herbicidal and growth regulating properties.In the above formula the symbols have the following meanings:R.sup.1 is hydrogen, halogen, nitro, cyano, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.1 -C.sub.4 alkylsulfinyl, --CO--R.sup.8, --NR.sup.9 R.sup.10, --CO--NR.sup.11 R.sup.12 or --SO.sub.2 --NR.sup.13 R.sup.14,R.sup.2 is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfinyl or C.sub.1 -C.sub.4 alkylsulfonyl,R.sup.3 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl or cyano,R.sup.4 is hydrogen or C.sub.1 -C.sub.4 alkyl,R.sup.5 is hydrogen, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy,R.sup.6 and R.sup.7 are each independently hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 haloalkylthio, C.sub.2 -C.sub.4 alkoxyalkyl, C.sub.3 -C.sub.6 cycloalkyl or --NR.sup.15 R.sup.16,R.sup.8 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 alkylthio or C.sub.2 -C.sub.4 alkoxyalkoxy,R.sup.9, R.sup.10, R.sup.11, R.sup.12, R.sup.13, R.sup.15 and R.sup.16 are each independently hydrogen or C.sub.1 -C.sub.4 alkyl,A is a radical --Y--(CH.sub.2).sub.n --R.sup.17 or ##STR2## R.sup.17 is a 5- or 6-membered unsaturated heterocyclic radical, R.sup.18 and R.sup.19 are each independently hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, nitro or cyano,E is nitrogen or --CH.dbd.,Y is oxygen, sulfur or a direct bond,T and Z are each independently oxygen or sulfur, andn is 0 or 1. | ||||||
| 105 | Anti-emetic quinuclidinyl benzamides | US51880 | 1987-05-18 | US4820715A | 1989-04-11 | Ivo Monkovic; David Willner |
| Novel substituted benzamides of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and A are as defined herein are useful in the treatment of emesis, and particularly chemotherapy-induced emesis in cancer patients. Some of the compounds are also useful in disorders relating to impaired gastric motility. | ||||||
| 106 | Pharmaceutical products providing enhanced analgesia | US074655 | 1987-07-17 | US4812446A | 1989-03-14 | Larry M. Brand |
| An analgesic composition comprising capsaicin or a capsaicin analogue and an analgesic selected from the class of non-steroidal anti-inflammatory, antipyretic and analgesic drugs is disclosed. This combination has been found to exhibit unexpectedly enhanced analgesic activity in humans and lower animals without a corresponding increase in undesirable side effects. | ||||||
| 107 | Fluorescent dyes and biological and analytical uses thereof | US824765 | 1986-01-31 | US4812393A | 1989-03-14 | Ramanuj Goswami; Chin H. Chen |
| Substituted 4-oxo-4H-benz-[d,e] anthracenes are fluorescent dyes which are useful in biomedical studies and analytical determinations. They are particularly useful in assays for living organisms, e.g. microorganisms, carried out at a pH of 9 or less. For these determinations, the fluorescent dyes can be attached to reducible compounds which will release the dye upon reduction. Alternatively, these dyes can be used in assays for hydrolytic enzymes or biological cells containing these enzymes. For these determinations, the dyes are attached to blocking groups. | ||||||
| 108 | Method for the treatment of ischemia and reperfusion syndromes | US72714 | 1987-07-13 | US4806567A | 1989-02-21 | Vittorio Ferrari; Angelo Carenzi; Davide Della Bella |
| A method for the treatment of ischemia and reperfusion syndromes, which consists in administering to a patient in need thereof a therapeutically effective amount of a compound of the formula: ##STR1## in which R is hydrogen or a C.sub.1 -C.sub.6 alkyl group, or of a salt thereof, when R.dbd.H, with a pharmaeutically acceptable base.New compounds and pharmaceutical compositions useful in the method of this invention. | ||||||
| 109 | Substituted 1,2,3-thia-diazole-4-thiolates | US883189 | 1986-07-08 | US4803280A | 1989-02-07 | Ving J. Lee; William V. Curran |
| Intermediates useful for synthesis of cephalosporins are disclosed, which intermediates are concerned with 1,2,3-thiadiazole-4-thiolates and the preparation of such thiolates. | ||||||
| 110 | Fungicidal alpha-substituted acrylates | US893272 | 1986-08-05 | US4802913A | 1989-02-07 | John Clough; Christopher R. A. Godfrey |
| Compounds of formula (I): ##STR1## and stereoisomers thereof, wherein V is an oxygen or a sulphur atom; X and Y, which may be the same or different, are hydrogen or halogen atoms, or optionally substituted alkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkynyl, haloalkyl, alkoxy, haloalkoxy, optionally substituted aryloxy, optionally substituted arylalkoxy, optionally substituted acyloxy, optionally substituted amino, acylamino, nitro, nitrile, --CO.sub.2 R.sup.3, --CONR.sup.4 R.sup.5, or --COR.sup.6 groups; or the groups X and Y, when they are in adjacent positions on the phenyl ring, may join to form a fused ring, either aromatic or aliphatic, optionally containing one or more heteroatoms; and Z is optionally substituted methylene, optionally substituted amino, oxygen or sulphur and when Z is a substituted methylene group, the substituent may join the 2-position of the phenyl ring to form a non-aromatic fused ring; R.sup.1 and R.sup.2 are alkyl groups containing from one to four carbon atoms, optionally substituted with one or more halogen atoms; and R.sup.3, R.sup.4, R.sup.5 and R.sup.6, which may be the same or different, are hydrogen atoms or optionally substituted alkyl, cycloalkyl, alkenyl, alkynyl, optionally substituted aryl, optionally substituted aralkyl, or cycloalkylalkyl groups; and metal complexes thereof. | ||||||
| 111 | Herbicidal cyclohexane-1,3-dione derivatives | US886263 | 1986-07-16 | US4795487A | 1989-01-03 | Keith G. Watson; Craig G. Lovel |
| The invention concerns novel compounds of the formula I ##STR1## wherein: the substituent X is chosen from cyano, carbamoyl and thiocarbamoyl;Z is selected from hydrogen, methyl, C.sub.1 to C.sub.4 alkanoyl, sulfamoyl, dimethylsulfamoyl and trifluoroacetylamino;R.sup.1 is selected from hydrogen, acyl and an inorganic or organic cation;R.sup.2 is selected from alkyl, substituted alkyl, alkenyl, haloalkenyl and alkynyl;R.sup.3 is selected from alkyl; andR.sup.4 is selected from hydrogen, alkyl, and alkoxycarbonyl.The compounds of the invention show herbicidal properties and plant growth regulating properties and in further embodiments and the invention provides processes for the preparation of compounds of formula I, intermediates useful in the preparation of the compounds of formula I, compositions containing as active ingredient a compound of formula I, and herbicidal and plant growth regulating processes utilizing compounds of formula I. | ||||||
| 112 | Process for the preparation of benzyl trifluoromethyl sulfide | US52074 | 1987-05-21 | US4788012A | 1988-11-29 | Catherine Francese; Marc Tordeux; Claude Wakselman |
| A process for the preparation of a benzyl trifluoromethyl sulfide by bringing a benzyl thiocyanate and trifluoromethyl bromide into contact with zinc in a polar aprotic solvent or a pyridine. The invention also relates to a process for the preparation of trifluoromethane sulfonyl chloride by bringing a benzyl trifluoromethyl sulfide into contact with chlorine and water. | ||||||
| 113 | Preparation of iodonium and sulfonium triflates | US088779 | 1987-08-24 | US4786441A | 1988-11-22 | Robert D. Miller |
| An iodonium or sulfonium triflate is prepared by dissolving or slurring a iodonium or sulfonium halide in an organic solvent and reacting it with a trimethylsilyl triflate. | ||||||
| 114 | Certain 3-(substituted thio)-2-benzoyl-cyclohex-2-enones | US872078 | 1986-06-09 | US4762551A | 1988-08-09 | Christopher G. Knudsen |
| A compound of the formula ##STR1## wherein R is halogen, C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.2 alkoxy, nitro; cyano; C.sub.1 -C.sub.2 haloalkyl, or R.sup.a SO.sub.n -- wherein n is 0 or 2 and R.sup.a is C.sub.1 -C.sub.2 alkyl; R.sup.1 is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sup.2 is hydrogen or C.sub.1 -C.sub.4 alkyl; or R.sup.1 and R.sup.2 together are alkylene having 2 to 5 carbon atoms; R.sup.3 is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sup.4 is hydrogen or C.sub.1 -C.sub.4 alkyl; or R.sup.3 and R.sup.4 can be oxo; R.sup.5 is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sup.6 is hydrogen or C.sub.1 -C.sub.4 alkyl; or R.sup.5 and R.sup.6 together are alkylene having 2 to 5 carbon atoms; and R.sup.7 and R.sup.8 independently are (1) hydrogen; (2) halogen; (3) C.sub.1 -C.sub.4 alkyl; (4) C.sub.1 -C.sub.4 alkoxy; (5) trifluoromethoxy; (6) cyano; (7) nitro; (8) C.sub.1 -C.sub.4 haloalkyl; (9) R.sup.b SO.sub.n -- wherein n is the integer 0, 1 or 2; and R.sup.b is (a) C.sub.1 -C.sub.4 alkyl; (b) C.sub.1 -C.sub.4 alkyl substituted with halogen or cyano; (c) phenyl; or (d) benzyl; (10) --NR.sup.c R.sup.d wherein R.sup.c and R.sup.d independently are hydrogen or C.sub.1 -C.sub.4 alkyl; (11) R.sup.e C(O)-- wherein R.sup.e is C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy; (12) SO.sub.2 NR.sup.c R.sup.d wherein R.sup.c and R.sup.d are as defined; or (13) --N(R.sup.c)C(O)R.sup.d wherein R.sup.c and R.sup.d are as defined; m is the integer 0, 1 or 2; and R.sup.9 is C.sub.1 -C.sub.4 alkyl, phenyl, cyano, substituted phenyl, or --(CH.sub.2).sub.x --C(O)O-- (C.sub.1 -C.sub.4 alkyl) whrein X is the integer 1, 2 or 3. | ||||||
| 115 | Oxime ethers as herbicidal safeners | US730512 | 1985-05-06 | US4759789A | 1988-07-26 | Henry Martin; Urs Fricker |
| The invention relates to novel oxime ethers of the formula I ##STR1## wherein R.sub.1 is hydrogen, halogen, lower alkyl, lower haloalkyl, lower alkoxy, lower haloalkoxy, lower alkylthio, lower haloalkylthio, lower alkylsulfinyl, lower alkylsulfonyl, lower haloalkylsulfinyl, lower haloalkylsulfonyl or nitro, each of R.sub.2 and R.sub.3 is hydrogen, halogen, lower alkyl, lower alkoxy or lower haloalkoxy, and Q is an unsubstituted or substituted lower alkyl, lower alkenyl, lower alkynyl or cycloalkyl group, a lower alkanoyl radical, an aliphatic, cycloaliphatic, aromatic or heterocyclic acyl radical which may be substituted or unsubstituted, a carbonyl or thiocarbonyl radical, an aryl or aralkyl radical, an acylimidomethyl radical, a phthalimidomethyl radical or a heterocyclic radical.These compounds are able to act as antidotes or safeners for protecting cultivated plants from the phytotoxic action of aggressive herbicides. Preferred crops are sorghum, cereals, maize and rice, and herbicides are chiefly chloroacetanilides and thiocarbamates. | ||||||
| 116 | Compositions stabilized with substituted amino carbamates | US855662 | 1986-04-25 | US4758614A | 1988-07-19 | Stephen D. Pastor; Edward T. Hessell; Ramanathan Ravichandran |
| Substituted amino carbamate derivatives corresponding to the formula ##STR1## are effective in stabilizing organic materials against oxidative, thermal and actinic degradation, said derivatives being particularly effective as color improvers and process stabilizers in organic materials containing phenolic antioxidants and/or metal salts of fatty acids and/or hindered amine light stabilizers and/or organic phosphorus compounds; and certain of said derivatives as new compounds. | ||||||
| 117 | Carbamate additives for low phosphorus or phosphorus free lubricating compositions | US841061 | 1986-03-18 | US4758362A | 1988-07-19 | Betsy J. Butke |
| A phosphorus free or a low phosphorus containing lubricant composition is provided by formulating the composition with an additive of the formula ##STR1## wherein R.sub.1 and R.sub.2 are independently alkyl of 1 to about 7 carbons, aryl, aralkyl or together form an alicyclic or heteroalicyclic radical in which the ring is completed through the nitrogen; X is O or S; a is 1 or 2; R.sub.3 and R.sub.4 are independently H, alkyl or aryl; and Z is ##STR2## wherein R.sub.5 is hydrogen, alkyl, or aralkyl, and ##STR3## wherein Y is H, OH, R.sub.6 where R.sub.6 is alkyl, aryl or aralkyl, OR.sub.6, OR.sub.7 --OH, where R.sub.7 is alkylene of 1 to about 7 carbon atoms, and NR.sub.8 R.sub.9 where R.sub.8 and R.sub.9 are independently hydrogen, alkyl, cycloaliphatic, heteroalicyclic or together form an alicyclic or heteroalicyclic radical in which the ring is completed through the nitrogen; with the proviso that when a is 1, Y is not OR.sub.6.These additives impart improved extreme pressure and anti-wear properties to lubricant compositions. | ||||||
| 118 | Benzoylaminomethylpyrazoles and -furans, composition containing them, and fungicidal and plant growth regulating method of using them | US932102 | 1986-11-18 | US4752321A | 1988-06-21 | Stephen P. Heaney; Patrick J. Crowley; Laurence G. Reynolds |
| A compound of the general formula (I): ##STR1## wherein R is C.sub.2 -C.sub.4 alkenyl or C.sub.2 -C.sub.4 alkynyl, both optionally substituted by lower alkyl, halogen or trialkylsilyl; E is CN or CSHN.sub.2 ; and Y is C.sub.1 -C.sub.4 alkoxy, C.sub.3 -C.sub.4 alkenyloxy, C.sub.3 -C.sub.4 alkynyloxy, 1-pyrazolyl or 2-furyl. The compounds have fungicidal and plant growth regulating activity. | ||||||
| 119 | Process for preparing organo-sulfonium halides | US584972 | 1984-03-01 | US4743403A | 1988-05-10 | Sreeramulu Nagubandi |
| Disclosed is a process for preparing organo-sulfonium halide of the formula ##STR1## wherein X is an halide, R.sub.1, R.sub.2 and R.sub.3 are the same or different and are selected from the group consisting of: alkyl having 1 to 24 carbon atoms, inclusive; allyl having 2 to 24 carbon atoms, inclusive; alkenyl having 2 to 24 carbon atoms, inclusive; alkynyl having 2 to 24 carbon atoms, inclusive; aryl having 6 to 24 carbon atoms, inclusive; and wherein said alkyl, allyl, alkenyl, alkynyl and aryl are optionally substituted with a group that is inert to organo-sulfides comprising: reacting an alcohol, e.g. methanol, with an halide derivative which when reacted with an organo-sulfide forms an organo-sulfonium halide, e.g., thionyl halide, sulfuryl halide and carbonyl halide; and then adding an organo-sulfide, e.g., dimethyl sulfide, to the above reaction mixture with agitation while allowing the gas formed to be eliminated so that the organo-sulfonium halide, e.g., trimethyl sulfonium halide, is formed. This process can take place in the presence of an insert solvent, e.g., methylene chloride. | ||||||
| 120 | Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes | US771284 | 1985-08-30 | US4735793A | 1988-04-05 | Alun G. Jones; Alan Davison; James Kronauge; Michael J. Abrams |
| A coordination complex comprising a radionuclide selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt and Re and an isonitrile ligand of the formula:(CNX)R,where X is a lower alkyl group having 1 to 4 carbon atoms, wherein R is selected from the group consisting of COOR.sup.1 and CONR.sup.2 R.sup.3 where R.sup.1 can be H, a pharmaceutically acceptable cation, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, R.sup.2, and R.sup.3 can be H, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, and R.sup.2 and R.sup.3 can be the same or different is disclosed. Kits that can be used to form these complexes are also disclosed. | ||||||
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