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序号 专利名 申请号 申请日 公开(公告)号 公开(公告)日 发明人
41 치환된 시클로프로판카르보알데히드의 제조 방법 KR1019900001162 1990-02-01 KR1019900012900A 1990-09-03 한스-루이디쾨넬; 존그레이딩월
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42 시클로 프로판 카복실산의 새로운 유도체류 KR810001819 1981-05-22 KR830006166A 1983-09-17
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43 PROCESS FOR THE PREPARATION OF 3-(METHYLTHIO)PROPANAL EP93922171.9 1993-09-09 EP0703890B1 1999-04-07 HSU, Yung, C.; RUEST, Dennis, A.
A process for the continuous preparation of 3-(methylthio)propanal. A liquid reaction medium is contacted with a gaseous acrolein feed stream in a gas/liquid contact zone. The reaction medium contains 3-(methylthio)propanal, methyl mercaptan and a catalyst for the reaction between methyl mercaptan and acrolein. The gaseous acrolein feed stream comprises acrolein vapor and non-condensable gas. Acrolein is transferred from the acrolein feed stream to the reaction medium and reacts with methyl mercaptan in that medium to produce a liquid reaction product containing 3-(methylthio)propanal. The non-condensable gas is separated from the liquid reaction product. The reaction product is divided into a product fraction and a circulating fraction, and the circulating fraction is recycled to the gas/liquid contact zone.
44 COMBINATORIAL LIBRARIES HAVING AMINODIOL MONOMER SUBUNITS EP96918360 1996-06-07 EP0865439A4 1998-11-11 HEBERT NORMAND
45 PEPTIDYLAMINODIOLS. EP88900918 1987-12-22 EP0295294A4 1990-04-10 FUNG ANTHONY K L; KEMPF DALE JOHN; LULY JAY RICHARD; ROSENBERG SAUL HOWARD; PLATTNER JACOB JOHN
46 USE OF (+/-)-CIS-GAMMA-IRONE IN PERFUMERY AND NOVEL PROCESS FOR PREPARING SAME. EP85901068 1985-02-21 EP0211954A4 1988-12-28 KAWANOBE TSUNEO; KOGAMI KUNIO
A novel perfume composition containing an effective amount of ( 9E)-cis-gamma-irone (formula (B)), which has not been heretofore applied in the field of perfumery, in perfumes or flavored articles, a method for imparting, changing or enhancing aromatic properties by compounding ( 9E)-cis-gamma-irone with perfumes or articles being flavored, and a novel process for preparing ( 9E)-cis-gamma-irone.
47 Compounds and compositions having anti-inflammatory and analgesic activity. EP86304377 1986-06-09 EP0206609A1 1986-12-30 BERMAN ELIZABETH F; BUCKWALTER BRIAN; CUPPS THOMAS L; GARDNER JOSEPH H
Substituted phenylacetic acid amide compounds, and pharmaceutically-acceptable salts thereof, of the formula: wherein X is O or S; R1 is H, OH or CH3; R2 is straight chain alkenyl, branched chain or cyclic hydrocarbon having from about 7 to about 24 carbon atoms; R3 is OH, OSO3-, OPO3<-><-> or a short chain ester with from about 1 to about 6 carbon atoms.
48 Haloalkoxy anilide derivatives of 2-(4-heterocyclic oxyphenoxy)-alkanoic acids and their use as herbicides. EP86105675 1986-04-24 EP0205821A1 1986-12-30 TURNER JAMES A; ZORNER PAUL S; JACKS WENDY S; MOORE SUSAN K
The present invention is directed to novel substituted aniline compounds, the optically active isomers of said compounds, compositions containing said compounds, and the use of these compounds in the selective kill and control of grassy weeds in the presence of valuable crop plants especially corn plants.
49 N'-acylhydrazino-thiocarbonic-acid-o-carbamoylmethyl ester EP84116311 1984-12-27 EP0151312A3 1986-12-30 MAURER, FRITZ, DR.
50 Hydrazino-thiocarbonic-acid-o-carbamoylmethyl ester EP84116312 1984-12-27 EP0148500A3 1986-12-30 MAURER, FRITZ, DR.
51 NAPHTALENE AMINOALKYLENE ETHERS AND THIOETHERS, AND THEIR PHARMA CEUTICAL USES. EP84902127 1984-04-27 EP0148201A4 1985-09-26 CAMPBELL HENRY FLUD; KUHLA DONALD ERNEST; STUDT WILLIAM LYON
52 ACRYLAMIDOACYLATED OLIGOMERS. EP82903612 1982-10-27 EP0091956A4 1984-04-24 RASMUSSEN JERALD K; HEILMANN STEVEN M; PALENSKY FREDERICK J
53 5-alkyl-3-alkylthiopropionthioates, process for their preparation and their use as pharmaceutical compositions EP81101913 1981-03-14 EP0036991B1 1983-11-16 JACOBI, HAIREDDIN, DR.; OPITZ, WOLFGANG, DR.
54 NOVEL CRYSTALLINE FORM OF OXAMYL PROCESS FOR ITS PREPARATION AND USE OF THE SAME US16464583 2017-10-20 US20210045384A1 2021-02-18 James Timothy BRISTOW
A crystalline form of oxamyl is provided. The crystalline form of oxamyl is of formula (I): A crystal preparation process, the analyses of the crystal through various analytical methods and using the crystalline form to prepare a stable agrochemical formulation is also provided. The use of various solvents towards the crystalline form preparation conditions is also provided.
55 2-substituted-3-phenylpropionic acid derivatives and their use in the treatment of inflammatory bowel disease US14301569 2014-06-11 US09181181B2 2015-11-10 Anders Broo; Johan Gottfries; Michael Kossenjans; Li Lanna; Eva-Lotte Lindstedt-Alstermark; Kristina A. Nilsson; Bengt Ohlsson; Maria Thorstensson; Maria Boije
The present invention relates to 2-(substituted sulphur, sulphone or sulphoxide)-3-(substituted phenyl)propionic acid derivatives, 2-(substituted oxygen)-3-(substituted phenyl)propionic acid derivatives, benzoic acid derivatives, and derivatives of 2-methyl-2-(phenoxy or phenylthio)propanoic acid and 2-(methyl or ethyl)-2-(phenoxy or phenylthio)butanoic acid, to processes for preparing such compounds, to their use in the treatment of inflammatory conditions, and to pharmaceutical compositions containing them.
56 2-substituted-3-phenylpropionic acid derivatives and their use in the treatment of inflammatory bowel disease US13046288 2011-03-11 US08785681B2 2014-07-22 Anders Broo; Johan Gottfries; Michael Kossenjans; Li Lanna; Eva-Lotte Lindstedt-Alstermark; Kristina A. Nilsson; Bengt Ohlsson; Maria Thorstensson; Maria Boije
The present invention relates to 2-(substituted sulphur, sulphone or sulphoxide)-3-(substituted phenyl)propionic acid derivatives, 2-(substituted oxygen)-3-(substituted phenyl)propionic acid derivatives, benzoic acid derivatives, and derivatives of 2-methyl-2-(phenoxy or phenylthio)propanoic acid and 2-(methyl or ethyl)-2-(phenoxy or phenylthio)butanoic acid, to processes for preparing such compounds, to their use in the treatment of inflammatory conditions, and to pharmaceutical compositions containing them.
57 Use of one or more metal carriers to selectively kill mammalian cells US11472763 2006-06-22 US07655620B2 2010-02-02 Zoltan Kiss
Compositions and methods for decreasing the viability of cells, particularly aberrant non-healthy cells, and most particularly cancer cells, are disclosed. The primary agent that causes cell death is a toxic metal atom or ion. Embodiments of the invention provide compositions and methods to ensure that the toxic metal is directed to the desired cell or tissue. In one embodiment, the metal is bound to a sulfur-rich peptide or protein carrier containing a targeting moiety. Such metal-protein complex is targeted to the selected cells or tissues to enrich the cell or tissue site with the metal-containing peptide or protein molecules followed by administering a dithiocarbonyl which carries the metal from the protein inside the cells to induce cell death.
58 Thyroid receptor ligands US10826100 2004-04-15 US07557143B2 2009-07-07 Denis E. Ryono; Jon J. Hangeland; Todd J. Friends; Tamara Dejneka; Pratik Devasthale; Yolanda V. Caringal; Minsheng Zhang; Arthur M. P. Doweyko; Johan Malm; Andrei Sanin
Thyroid receptor ligands are provided which have the general formula I wherein: R1 is R2 and R3 are the same or different and are hydrogen, halogen, alkyl of 1 to 4 carbons or cycloalkyl of 3 to 5 carbons, provided that at least one of R2 and R3 is other than hydrogen; R4 is R5 and R6 are the same or different and are selected from hydrogen, aryl, heteroaryl, alkyl, cycloalkyl, aralkyl or heteroaralkyl. R7 is aryl, heteroaryl, alkyl, aralkyl, or heteroaralkyl; R8 is aryl, heteroaryl, or cycloalkyl; R9 is R7 or hydrogen; R10 is hydrogen, halogen, cyano or alkyl; R11 and R12 are each independently selected from the group consisting of hydrogen, halogen, alkoxy, hydroxy (—OH) cyano, and alkyl; R13 is carboxylic acid (COOH) or esters thereof, phosphonic and phosphinic acid or esters thereof, sulfonic acid, tetrazole, hydroxamic acid, thiazolidinedione, acylsulfonamide, or other carboxylic acid surrogates known in the art; R14 and R15 may be the same or different and are selected from hydrogen and alkyl, or R14 and R15 may be joined together forming a chain of 2 to 5 methylene groups [—(CH2)m-, m=2, 3, 4 or 5], thus forming 3- to 6-membered cycloalkyl rings; R16 is hydrogen or alkyl of 1 to 4 carbons; R17 and R18 are the same or different and selected from hydrogen, halogen and alkyl; n is 0 or an integer from 1 to 4; X is oxygen (—O—), sulfur (—S—), sulfonyl (—SO2—), sulfenyl (—SO—) selenium (—Se—), carbonyl (—CO—), amino (—NH—) or methylene (—CH2-); wherein the substituents are as described herein. In addition, a method is provided for preventing, inhibiting or treating diseases or disorders associated with metabolism dysfunction or which are dependent upon the expression of a T3 regulated gene, wherein a compound as described above is administered in a therapeutically effective amount.
59 4-(3,3-dihalo-allyloxy)phenoxy alkyl derivatives US10518888 2003-06-27 US07192965B2 2007-03-20 Werner Zambach; Peter Renold; Arthur Steiger; Stephan Trah; Roger Graham Hall
Compounds of formula wherein A1, A2 and A3 are each independently of the others a bond or a C1–C6alkylene bridge; A4 is a C1–C6alkylene bridge; D is CH or N; W is, for example, O, NR7 or S; T is, for example, a bond, O, NH or NR7; Q is O, NR7, S, SO or SO2; Y is O, NR7, S, SO or SO2; X1 and X2 are each independently of the other fluorine, chlorine or bromine; R1, R2 and R3 are, for example, H, halogen, CN, nitro, C1–C6alkyl, C1–C6haloalkyl, C1–C6alkylcarbonyl or C2–C6alkenyl; R4 is, for example, H, halogen, CN, nitro or C1–C6alkyl; R5 and R6 are, for example, H, CN, OH, C1–C6alkyl, C3–C8cycloalkyl, C3–C8cycloalkyl-C1–C6alkyl, C1–C6haloalkyl, C1–C6alkoxy or C1–C6haloalkoxy; R7 is H, C1–C6alkyl, C1–C6alkoxyalkyl or C1–C6alkylcarbonyl; k, when D is nitrogen, is 1, 2 or 3; or, when D is CH, is 1, 2, 3 or 4; and m is 1 or 2; and, where applicable, their possible E/Z isomers, E/Z isomeric mixtures and/or tautomers, in each case in free form or in salt form, a process for the preparation of those compounds and their use, pesticidal compositions in which the active ingredient has been selected from those compounds or an agrochemically acceptable salt thereof, a process for the preparation of those compositions and their use, plant propagation material treated with those compositions, and a method of controlling pests.
60 Preparation process of fluorenes US09768621 2001-01-25 US20010011144A1 2001-08-02 Hiroaki Mori
A tetrahydrofluorene, which is represented by the following formula (I) 1 wherein R1 to R6 each independently represent a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, or R1 and R2 are combined together to represent nullO, nullN or nullS, R7 and R8 each independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a halogen atom, a hydroxyl group or a carboxyl group, is subjected to a hydrogen transfer reaction in the presence of a hydrogen acceptor and a catalyst, whereby a fluorene and a hydride of the hydrogen acceptor are formed at the same time.
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