| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 21 | PRODRUGS | PCT/US2007004189 | 2007-02-15 | WO2007095383A3 | 2008-09-25 | WALTON RUTH J; SLADE RACHEL M; WILLARDSEN J ADAM; WEINER WARREN S; ANDERSON MARK B |
| The invention relates prodrugs of phenyl alkanoic acids. The prodrugs of the invention can enhance and/or improve delivery of the phenyl alkanoic acid moiety to a desired target tissue. | ||||||
| 22 | PROTIC SOLVENT IN A DEHYDROHALOGENATION PROCESS,THE PRODUCT OBTAINED THEREFROM AND LUBRICANT COMPOSITIONS CONTAINING SAME | PCT/US8800765 | 1988-03-11 | WO8807031A3 | 1988-10-20 | SOWERBY ROGER LEE; DI BIASE STEPHEN AUGUSTINE |
| A process for producing a sulfurized olefin product substantially free of ash containing waste is disclosed. The process involves dehydrohalogenation of an olefin/sulfur halide complex by contacting the complex with a protic solvent in the absence of any metal ion. The process allows for the solvolytic dehydrohalogenation of the complex. The sulfurized olefin product obtained is isolated and may be subjected to further processing to remove any remaining halides. The resulting sulfurized olefin is a useful additive in lubricating oils. | ||||||
| 23 | USE OF MALONIC ACID DERIVATIVE COMPOUNDS FOR INCREASING CROP YIELD | PCT/US8700647 | 1987-03-30 | WO8705897A3 | 1988-04-07 | FRITZ CHARLES DAVID; COOKE ANSON RICHARD; MANNING DAVID TREADWAY; CAPPY JAMES JOSEPH; WHEELER THOMAS NEIL; MOORE BARBARA AUXIER |
| Increasing crop yield comprises applying a cpd. of formula (I), R1 and R2 are independently a substd. or unsubstd., carbocyclic or heterocyclic ring system, Y1 and Y2 are independently a substd. or unsubstd. heteroatom, Y3 and Y3 are independently hydrogen, or a substd. or unsubstd. heteroatom carbon atom, or a substd. or unsubstd. branched or straight chain contg. two or more carbon atoms or heteroatoms or (e.g.) halogen, alkylcarbonyl, formyl, alkylcarbonylalkyl, alkoxycarbonylalkyl, etc. Y5 and Y6 are independently oxygen or sulphur. - | ||||||
| 24 | HEXASUBSTITUTED CYCLOHEXANE COMPOUNDS | PCT/EP8700318 | 1987-06-19 | WO8800940A3 | 1988-02-25 | PRAEFCKE KLAUS; KOHNE BERND; DORSCH DIETER; RIEGER BERNHARD |
| Hexasubstituted cyclohexane compounds which are suitable as components of discotic liquid crystal phases. | ||||||
| 25 | SYNTHESIS OF ANTIULCER COMPOUNDS | PCT/EP8700172 | 1987-03-27 | WO8705902A3 | 1987-11-19 | REINER ALBERTO |
| To synthesize molecules with antiulcer action, specifically ranitidine, niperotidine and cimetidine, having the formula: |
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| 26 | SOLUTIONS DE MATERIAUX MOLECULAIRES CONDUCTEURS ET ABSORBANTS ELECTROMAGNETIQUES ELABORES A PARTIR DE CES SOLUTIONS | PCT/EP2011/053662 | 2011-03-11 | WO2011110653A1 | 2011-09-15 | SOUQUE, Matthieu; VENDIER, Olivier; VALADE, Lydie; DE CARO, Dominique; DESMARRES, Jean-Michel; COURTADE, Frédéric |
Solution de matériaux moléculaires conducteurs et absorbants électromagnétiques élaborés à partir de ces solutions L'invention concerne une solution stable en matériau moléculaire, caractérisée en ce qu'elle comprend : - un premier type de molécules organiques ou organo-métalliques (M1); - un second type de molécules organiques ou organo-métalliques ou d'ions (M2); - le premier type au moins présentant des groupements permettant une délocalisation électronique; - un troisième type de molécules (M3) pouvant être un agent tensio-actif ou un solvant, capable de s'associer au premier ou au second types de molécules ou d'ions (M1, M2), pour former un adduit en solution dont la présence empêche la précipitation du composé M1-M2 formé par réaction entre M1 et M2 et permet d'obtenir des solutions dont la concentration en composé M1-M2 est supérieure à celle régie par la constante de précipitation du composé M1-M2 en l'absence de molécules de troisième type (M3). L'invention concerne également un procédé de préparation de ladite solution. |
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| 27 | A METHOD FOR PREPARATION OF PERFLUOROALKYL SULFENYL CHLORIDE | PCT/IN2010/000385 | 2010-06-08 | WO2011080752A1 | 2011-07-07 | GHARDA, Keki Hormusji |
A process for the preparation of perfluoroalkyl sulfenyl chloride; said process comprising i) reacting a compound of formula (I) wherein R represents an aromatic group with or without a substituent; and R' represents a halogen, with at least one fluoride compound and thiophosgene in a solvent to obtain a reaction mass; ii) pulverizing the reaction mass with the help of beads to obtain a mixture containing trifluoromethyl thiomethyl benzene derivative; iii) isolating the trifluoromethyl thiomethyl benzene derivative from the mixture; iv) distilling the trifluoromethyl thiomethyl benzene derivative to obtain a purified trifluoromethyl thiomethyl benzene derivative; v) dissolving the purified trifluoromethyl thiomethyl benzene derivative in a solvent selected from the group consisting of dichloromethane, toluene, benzene, ethylene dichloride, mono chloro benzene, carbon tctra chloride, ortho dichloro benzene and tri chloro benzene; and vi) cleaving the trifluoromethyl thiomethyl benzene derivative by selective chlorinolysis by passing chlorine gas at a temperature in the range of about -10 to about 30°C to obtain perfluoroalkyl sulfenyl chloride |
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| 28 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | PCT/US1998/009297 | 1998-05-07 | WO98050030A1 | 1998-11-12 | |
| Compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R1 is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L2-, and (i) heterocyclic-L2-; R2 is selected from (a) (Ia), (b) -C(O)NH-CH(R14)-C(O)OR15, (c) (Ib), (d) -C(O)NH-CH(R14)-C(O)NHSO2R16, (e) -C(O)NH-CH(R14)-tetrazolyl, (f) -C(O)NH-heterocyclic, and (g) -C(O)NH-CH(R14)-C(O)NR17R18; R3 is substituted or unsubstituted heterocyclic or aryl, substituted or unsubstituted cycloalkyl or cycloalkenyl, (Ic), and -P(W)R |
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| 29 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | PCT/US1998/009296 | 1998-05-07 | WO98050029A1 | 1998-11-12 | |
| Compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R1 is (a) hydrogen, (b) lower alkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl -L2-, and (i) heterocyclic -L2-; R2 is selected from (a) formula (1), (b) -C(O)NH-CH(R14)-C(O)OR15, (c) formula (2), (d) -C(O)NH-CH(R14)-C(O)NHSO2R16, (e) -C(O)NH-CH(R14)-tetrazolyl, (f) -C(O)NH-heterocyclic, and (g) -C(O)NH-CH(R14)-C(O)NR17R18; R3 is substituted or unsubstituted heterocyclic or aryl, substituted or unsubstituted cycloalkyl or cycloalkenyl, formula (3), and -P(W)R |
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| 30 | HEXASUBSTITUTED CYCLOHEXANE COMPOUNDS | PCT/EP8700318 | 1987-06-19 | WO8800940A2 | 1988-02-11 | PRAEFCKE KLAUS; KOHNE BERND; DORSCH DIETER; RIEGER BERNHARD |
| Hexasubstituted cyclohexane compounds which are suitable as components of discotic liquid crystal phases. | ||||||
| 31 | SYNERGISTIC PLANT GROWTH REGULATOR COMPOSITIONS | PCT/US8700648 | 1987-03-30 | WO8705781A3 | 1987-12-03 | SEE RAYMOND MICHAEL; FRITZ CHARLES DAVID; MANNING DAVID TREADWAY; WHEELER THOMAS NEIL; COOKE ANSON RICHARD |
| Synergistic plant growth regulator compositions containing (i) an ethylene response or ethylene-type response inducing agent and (ii) a malonic acid derivative compound. This invention also relates to the use of said compositions for inducing synergistic plant growth regulating responses or ethylene responses or ethylene-type responses. | ||||||
| 32 | THROMBOXANE ANTAGONISTS IN THE TREATMENT OF HORMONE-DEPENDENT NEOPLASIAS | PCT/GB8600028 | 1986-01-16 | WO8604234A3 | 1986-09-12 | SENIOR JUDITH; TROUGHTON KAY MARIE |
| Compounds having thromboxane antagonist activity are of use in the treatment of hormone-dependent neoplasias for example oestrogen-dependent neoplasias. Thromboxane antagonists of particular value are compounds of formula (I) wherein formula (II) represents one of the divalent cyclic groups (III). The letters a and b indicating in each case the points of attachment of the substituents R1 and CV(R2)-NV'R, respectively; R1 is a 6-carboxyhex-2-enyl group or a modification thereof in which the group is altered by one, or an appropriate combination of two or more, of the following: (a) alteration of the position of the double bond, (b) reduction of the double bond, (c) alteration of the chain length through a decrease of one or two methylene groups or an increase of one to six methylene groups, (d) replacement of one or two methylene groups each separately by an oxygen or sulphur atom with the proviso that in the modified group no oxygen or sulphur atom is in an alpha position relative to either a doubly bonded carbon atom or to the carboxy group or a derivative thereof and that at least 2 carbon atoms separate any pair of oxygen and/or sulphur atoms; and (e) formation of an amide, ester or salt derivative of the carboxy groups; V and V' either each separately is hydrogen or together are the second bond of a carbon-nitrogen double bond; R2 is hydrogen, an aliphatic hydrocarbon group or an aliphatic hydrocarbon group substituted by an aromatic group directly or through an oxygen or sulphur atom; and R is a group -NH.CO.NH-R3 or -NH.CS.NH-R3 wherein R3 is an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted by one or more aromatic groups directly or through an oxygen or sulphur atom. | ||||||
| 33 | ENANTIOPURE TERPHENYLS WITH TWO ORTHO-ATROPISOMERIC AXES | PCT/EP2018/084513 | 2018-12-12 | WO2019115597A1 | 2019-06-20 | DHERBASSY, Quentin; WENCEL-DELORS, Joanna; COLOBERT, Françoise |
Enantiopure terphenyl presenting two ortho-located chiral axes having the following structural formula (I) : their process of synthesis and their use as mono or bidentate ligands for asymmetric organometallic reactions, as organocatalysts, as chiral base and as generator, with metal, of isolable chiral metallic complexes for applications in asymmetric catalysis and others. |
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| 34 | ALLYL ETHER-TERMINATED FLUOROALKYL SULFINIC ACIDS AND SALTS THEREOF | PCT/US2012039523 | 2012-05-25 | WO2012166578A2 | 2012-12-06 | QIU ZAI-MING |
| Described herein are allyl ether-terminated fluoroalkylsulfinic acids and salts thereof and methods of making. | ||||||
| 35 | LOW CHLORINE ODOR CONTROL COMPOSITIONS | PCT/US2011/036170 | 2011-05-12 | WO2011143376A1 | 2011-11-17 | SCHNEIDER, David, J.; SCHNEIDER, Charles, A. |
An odor control composition includes (a) at least one fragrance and (b) a halo active aromatic sulfonamide compound of Formula (I): wherein R1, R2, R3, R4, and R5 are independently selected from hydrogen, COOR', CON(R")2, alkoxy, CN, NO2, SO3R", halogen, substituted or unsubstituted phenyl, sulfonamide, halosulfonamide, and substituted or unsubstituted C1-C12 alkyl; R' is hydrogen, an alkali metal, an alkaline earth metal, substituted C1-C12 alkyl, or unsubstituted C1-C12 alkyl; and R" is hydrogen or substituted or unsubstituted C1-C12 alkyl, where the two R" groups in CON(R")2 may be independently selected; X is halogen; M is an alkali or alkaline earth metal; and n is the number of water molecules per molecule of the sulfonamide compound. |
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| 36 | PHOSPHINOAMIDITE CARBOXYLATES AND ANALOGS THEREOF IN THE SYNTHESIS OF OLIGONUCLEOTIDES HAVING REDUCED INTERNUCLEOTIDE CHARGE | PCT/US0132465 | 2001-10-16 | WO0232912A3 | 2003-03-13 | DELLINGER DOUGLAS J |
| Phosphinoamidite carboxylates and analogs are provided that have the structure of formula (I) wherein R<1>, R<2>, R<3>, R<4>, X, Y, Z and n are as defined herein. The compounds are useful as phosphitylating agents, e.g., in the phosphitylation of 3' and 5' hydroxyl groups of nucleosides and oligonucleotides. Also provided are phosphonocarboxylate and H-phosphonite carboxylate analogs of the compounds of formula (I). The compounds enable synthesis of phosphinocarboxylate and phosphonocarboxylate oligonucleotides having reduced internucleotide charge and enhanced nuclease resistance. | ||||||
| 37 | METHODS OF PREPARING DIDESMETHYLSIBUTRAMINE AND OTHER SIBUTRAMINE DERIVATIVES | PCT/US2002/011469 | 2002-04-12 | WO2002083631A1 | 2002-10-24 | SENANAYAKE, Chris, Hugh; HAN, Zhengxu; KRISHNAMURTHY, Dhileepkumar; PFLUM, Derek |
This invention encompasses novel methods of preparing sibutramine and sibutramine derivatives, and stereomerically pure sibutramine derivatives in particular. Examples of sibutramine derivatives include, but are not limited to, sibutramine metabolites such as desmethylsibutramine and didesmethylsibutramine. The invention further encompasses novel compounds useful in the synthesis of sibutramine derivatives. |
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| 38 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | PCT/US1999/015063 | 1999-07-01 | WO00001389A1 | 2000-01-13 | |
| Novel biphenyl sulfonamide compounds which are combined angiotensin and endothelin receptor antagonists are claimed along with methods of using such compounds in the treatment of conditions such as hypertension and other diseases, as well as pharmaceutical compositions containing such compounds. | ||||||
| 39 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | PCT/US1998/009298 | 1998-05-07 | WO98050031A1 | 1998-11-12 | |
| Compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R1 is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L2-, and (i) heterocyclic -L2-; R2 is selected from (a) Formula (Ia), (b) -C(O)NH-CH(R14)-C(O)OR15, (c) Formula (Ib), (d) -C(O)NH-CH(R14)-C(O)NHSO2R16, (e) -C(O)NH-CH(R14)-tetrazolyl, (f) -C(O)NH-heterocyclic, and (g) -C(O)NH-CH(R14)-C(O)NR17R18; R3 is heterocyclic, aryl, substituted or unsubstituted cycloalkyl; R4 is hydrogen, lower alkyl, haloalkyl, halogen, aryl, arylalkyl, heterocyclic, or (heterocyclic)alkyl; L1 is absent or is selected from (a) -L4-N(R5)-L5-, (b) -L4-O-L5-, (c) -L4-S(O)n-L5-, (d) -L4-L6-C(W)-N(R5)-L5-, (e) -L4-L6-S(O)m-N(R5)-L5-, (f) -L4-N(R5)-C(W)-L7-L5-, (g) -L4-N(R5)-S(O)p-L7-L5-, (h) optionally substituted alkylene, (i) optionally substituted alkenylene, and (j) optionally substituted alkynylene are inhibitors of protein isoprenyl transferases. Also disclosed are protein isoprenyl transferase inhibiting compositions and a method of inhibiting protein isoprenyl transferases. | ||||||
| 40 | AROMATIC AMIDES ABSORBING THE U.V. | PCT/FR8700039 | 1987-02-13 | WO8704923A3 | 1987-09-24 | ROBERT DOMINIQUE; JUNG LOUIS |
| Derivatives of amino-benzoic acids, hydroxy-benzoic acids, cinnamic acids, urocanic acids and benzimidazols have been synthetized. The photoprotector power of each class of compounds has been tested. It is the result of four different isolated or conjugate mechanisms. Mechanism 1: absorption of ultraviolet radiations between 360 nm and 260 nm (UVB and/or UVA). Mechanism 2: prolonged absorption of ultraviolet radiations between 360 nm and 260 nm by preferential fixation and in a prolonged way at the epiderm of the human skin of the compound and this by introducing into their chemical structure sulphured or not, peptidic, amino-acid groups. Mechanism 3: induction of the melanogenesis, natural protection system of the skin. Mechanism 4: selection of a compound which is either liposoluble or hydrosoluble according to the galenic form (solution, emulsion, spray). The present invention claims the chemical structure of new compounds, their synthesis, photoprotective activity and the utilization of all the disclosed compounds in order to avoid photodermatosis consecutive to the administration of medicaments, to the use of cosmetics and/or perfumes by man. | ||||||
