| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 181 | BROAD SPECTRUM GPCR BINDING AGENTS | US16703534 | 2019-12-04 | US20200200765A1 | 2020-06-25 | Sergiy Levin; Michelle Boursier; Rachel Friedman Ohana; Thomas Kirkland; Keith Wood |
| Provided herein are broad-spectrum G-Protein coupled receptor (GPCR) binding agents, detectable/isolatable compounds comprising such binding agents (e.g., broad-spectrum GPCR binding agents linked to a functional element and/or solid surface), and methods of use thereof for the detection/isolation of GPCRs. | ||||||
| 182 | Method for preparing rubber composition using aminosilane-based terminal modifier introducing functional group, and rubber composition prepared thereby | US15558453 | 2016-06-17 | US10351635B2 | 2019-07-16 | Seung-Ho Choi; Min-Soo Kim; Cheol-Jae Kim; Zeong-Back Kim; Ji-Eun Kim; Won-Mun Choi; Dae-June Joe |
| The present invention relates to a terminal modified and conjugated diene-based polymer rubber composition including a terminal modified and conjugated diene-based polymer which is characterized in that an aminosilane-based terminal modifier represented by Formula 1 or Formula 2 is combined at the terminal of a conjugated diene-based polymer, and a method for preparing the same. | ||||||
| 183 | Sulfonium compound, making method, resist composition, and pattern forming process | US15590422 | 2017-05-09 | US10248022B2 | 2019-04-02 | Masaki Ohashi; Ryosuke Taniguchi |
| A sulfonium compound having formula (1) exerts a satisfactory acid diffusion control function wherein R1, R2 and R3 are a C1-C20 monovalent hydrocarbon group which may contain a heteroatom, p=0-5, q=0-5, and r=0-4. A resist composition comprising the sulfonium compound is processed by lithography to form a resist pattern with improved resolution, LWR, MEF and CDU. | ||||||
| 184 | Use of metal scavengers for removal of ruthenium residues | US14443048 | 2014-06-24 | US09533937B2 | 2017-01-03 | Grzegorz Szczepaniak; Stefan J. Czarnocki; Krzysztof Skowerski |
| The invention concerns use of metal scavengers of the formula (1), wherein the variables are as defined in the description of the invention, for removal of ruthenium residues, compounds, or complexes thereof, from the post-reaction mixtures, from the products of reactions catalyzed with ruthenium complexes, as well as from organic compounds contaminated with ruthenium. | ||||||
| 185 | Method and substances for preparation of N-substituted pyridinium compounds | US13945556 | 2013-07-18 | US08754111B2 | 2014-06-17 | Peter Gebauer; Dieter Heindl; Carina Horn |
| A method for the synthesis of N-substituted 3-acylated pyridinium compounds by reacting a pentamethine precursor with a primary amine. | ||||||
| 186 | Process for the preparation of isocyanates | US12065680 | 2006-09-05 | US08546605B2 | 2013-10-01 | Matthias Kloetzer; Eckhard Stroefer; Volker Krase; Andreas Schmidt; Peter Scherbel |
| The invention provides a multistage process for continuously preparing organic, distillable polyisocyanates, preferably diisocyanates, more preferably aliphatic or cycloaliphatic diisocyanates, by reacting the corresponding organic polyamines with carbonic acid derivatives and alcohols to low molecular mass monomeric polyurethanes, and thermally cleaving said polyurethanes, in which at defined reaction stages the polyisocyanates prepared and unusable residues are separated off, and reusable by products and intermediates are recycled to upstream stages. | ||||||
| 187 | Photocurable and thermosetting resin composition and printed circuit boards made by using the same | US13560286 | 2012-07-27 | US08492070B2 | 2013-07-23 | Hideaki Kojima; Hidekazu Miyabe; Shouji Minegishi; Naoki Yoneda; Yoshitaka Hirai |
| A photocurable and thermosetting composition comprises (A) a carboxyl group-containing resin having at least one carboxyl group in its molecule, (B) a photopolymerization initiator having an oxime linkage represented by the following general formula (I), (C) a reactive diluent, and (D) an epoxy compound having two or more epoxy groups in its molecule. The above-mentioned photopolymerization initiator (B) is incorporated into a formulation which is different from at least a formulation into which the above-mentioned carboxyl group-containing resin (A) and the above-mentioned reactive diluent (C) are incorporated to formulate a system comprising at least two parts. | ||||||
| 188 | Doxorubicin adjuvants to reduce toxicity and methods for using the same | US12369657 | 2009-02-11 | US08227517B2 | 2012-07-24 | William A. Garland; Brian D. Frenzel |
| Methods are provided for using doxorubicin active agents in which reduced host toxicity is observed. Aspects of the methods including administering to a subject an effective amount of a doxorubicin active agent in conjunction with a doxorubicin toxicity-reducing adjuvant, e.g., a nitrone compound, or a nitrone compound in combination with a bisdioxopiperazine compound. Also provided are compositions for use in practicing the subject methods. The methods and compositions find use in a variety of different applications, including in the treatment of a variety of different disease conditions. | ||||||
| 189 | CHROMENE COMPOUND | US13496689 | 2010-09-15 | US20120170098A1 | 2012-07-05 | Toshiaki Takahashi; Junji Takenaka; Junji Momoda; Mitsuyoshi Sando; Kazuhiro Teranishi |
| A photochromic chromene compound having an indeno(2,1-f)naphtho(1,2-b)pyran structure as its basic skeleton, an aryl group or a heteroaryl group at the 6-position carbon atom of the structure and an electron donor group having a Hammett constant σp of not more than −0.1 at the 7-position carbon atom. | ||||||
| 190 | Process for production of isocyanate, isocyanate produced by the process, and use of the isocyanate | US11988490 | 2006-07-20 | US08183407B2 | 2012-05-22 | Chitoshi Shimakawa; Hiroyuki Morijiri; Hidetoshi Hayashi; Norihiko Fukatsu; Seiichi Kobayashi; Homare Yumoto; Junichi Ishiyama; Shinya Tsuchiyama |
| An isocyanate has been widely used as a starting material for the production of a polyurethane material, a polyisocyanurate material or the like which is suitably applicable to the field of optical materials. Disclosed is a process for producing an isocyanate which includes a step for producing the isocyanate in the form of a hydrochloride with improved productivity. A process for producing a linear or cyclic aliphatic isocyanate comprising the step of reacting a linear or cyclic aliphatic amine with hydrogen chloride to yield a hydrochloride of the linear or cyclic aliphatic amine, the step being performed under a pressure higher by 0.01 MPa or more than the atmospheric pressure. | ||||||
| 191 | Nitric oxide donating prostamides | US12991855 | 2009-05-11 | US08101658B2 | 2012-01-24 | Francesca Benedini; Stefano Biondi; Valerio Chiroli; Wesley Kwan Mung Chong; Liming Dong; Achim Hans-Peter Krauss; Fabio Nicoli; Ganesh Prasanna; William Francois Vernier; Yi Yang |
| Nitroderivatives of prostaglandins having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension. | ||||||
| 192 | Method for the purification of isocyanates | US11523556 | 2006-09-20 | US08088944B2 | 2012-01-03 | Andreas Woelfert; Hans-Juergen Pallasch; Eckhard Stroefer; Heinrich-Josef Blankertz |
| Isocyanates are prepared by a process in which a product stream from the isocyanate synthesis is purified. | ||||||
| 193 | Process for preparing 2-aminooxyethanol | US12515820 | 2007-11-03 | US07968747B2 | 2011-06-28 | Sergii Pazenok; Norbert Lui |
| The invention relates to a process for preparing aminoglycol by reacting ketoximes with ethylene oxide under basic conditions to give a substituted 2-hydroxyethyl ketoxime and subsequently reacting the latter with an acid to give aminoglycol. | ||||||
| 194 | Process for the preparation of liquid, storage-stable organic isocyanates containing carbodiimide and/or uretonimine groups | US11649000 | 2007-01-03 | US07662989B2 | 2010-02-16 | Stefan Wershofen; Marcus Steinwegs |
| The invention relates to a process for the preparation of liquid, storage-stable isocyanate mixtures of low color number containing carbodiimide (CD) and/or uretonimine (UI) groups, the isocyanate mixtures obtainable by this process, the preparation of blends with further isocyanates and the process of the preparation of prepolymers containing isocyanate groups and/or polyurethane plastics, preferably polyurethane foams, from these isocyanate mixtures. | ||||||
| 195 | Use of 4-[(4-thiazolyl)phenoxy]alkoxy-benzamidine derivatives for treatment of osteoporosis | US10484094 | 2002-03-19 | US07662840B2 | 2010-02-16 | Hong-Suk Suh; Jin-Soo Lee; Pan-Soo Kim; Yun-Ha Hwang; Jei-Man Ryu; Yong-Ho Chung; Eun-Joo Kim; Do-Hui Kim; Yong-Youp Park |
| This invention relates to a pharmaceutical composition containing 4-[(4-thiazolyl)phenoxyl]alkoxy-benzamidine derivatives expressed by the following formula 1 for the prevention and treatment of osteoporosis and more particularly, to the use of 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxyl]pentoxy}-benzamidine or N-hydroxy-4-{5-[4-(5-iso-propyl-2-methyl-1,3-thiazol-4-yl)phenoxyl]pentoxy}-benzamidine expressed by the following formula 1, which is known as an antagonist of leukotriene-B4 receptor, as a pharmaceutical composition for the prevention and treatment of osteoporosis. [Formula 1], wherein, R is a hydrogen atom or a hydroxy group. | ||||||
| 196 | CATALYSTS HAVING ENHANCED STABILITY, EFFICIENCY AND/OR ACTIVITY FOR ALKYLENE OXIDE PRODUCTION | US12476908 | 2009-06-02 | US20090275763A1 | 2009-11-05 | Juliana G. Serafin; Albert C. Liu; Seyed R. Seyedmonir; Hwaili Soo; Thomas Szymanski |
| A catalyst for the manufacture of alkylene oxide, for example ethylene oxide, by the vapor-phase epoxidation of alkene containing impregnated silver and at least one efficiency-enhancing promoter on an inert, refractory solid support, said support incorporating a sufficient amount of zirconium component (present and remaining substantially as zirconium silicate) as to enhance at least one of catalyst activity, efficiency and stability as compared to a similar catalyst which does not contain the zirconium component. | ||||||
| 197 | Isomerisation of cis-2-pentenenitrile to form 3-pentenenitrile in a reactive distillation | US10585626 | 2005-01-27 | US07612224B2 | 2009-11-03 | Jens Scheidel; Tim Jungkamp; Michael Bartsch; Gerd Haderlein; Robert Baumann; Hermann Luyken |
| A process is described for isomerizing pentenenitrile in a reactant stream, wherein the isomerization is effected over a heterogeneous catalyst in a distillation column in such a way that, during the isomerization of the isomerization reactant, it is distillatively depleted in relation to the isomerization product in the reaction column of the distillation column. | ||||||
| 198 | Methods for the preparation of chemically misaminoacylated tRNA via protective groups | US11900323 | 2007-09-11 | US07524941B2 | 2009-04-28 | Jerzy Olejnik; Edyta Krzymanska-Olejnik; Sergey Mamaev; Kenneth J. Rothschild |
| The present invention relates to methods for the preparation of chemically aminoacylated tRNAs for the purpose of introduction of markers into nascent proteins. The present invention also relates to methods for the non-radioactive labeling, detection, quantitation and isolation of nascent proteins translated in a cellular or cell-free translation system utilizing chemically aminoacylated tRNAs. tRNA molecules are misaminoacylated with non-radioactive markers which may be non-native amino acids, amino acid analogs or derivatives. Markers may comprise cleavable moieties, detectable labels, reporter properties wherein markers incorporated into protein can be distinguished from unincorporated markers, or coupling agents which facilitate the detection and isolation of nascent protein from other components of the translation system. | ||||||
| 199 | Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives, intermediates thereof and methods for their preparation | US11941347 | 2007-11-16 | US07504532B2 | 2009-03-17 | Reinhold Öhrlein; Gabriele Baisch; Hans Jörg Kirner; Stephan Burkhardt; Martin Studer; Frank Bienewald |
| Synthesis methods for the preparation of intermediates which are suitable for the preparation of statin derivatives, and especially to synthesis methods for the intermediate of formula (VI) wherein Ra′ and Rc′ are each independently of the other hydrogen or hydroxy-protecting group, or together are a bridging hydroxy-protecting group; and Rb is a carboxy-protecting group. | ||||||
| 200 | Process for treating an aqueous medium containing cyclohexanone oxime and cyclohexanone | US10496873 | 2001-12-04 | US07408081B2 | 2008-08-05 | Arno Benneker; Henk Oevering; Johannes A. L. Brouwers |
| The invention relates to a process for treating an aqueous medium containing cyclohexanone oxime and cyclohexanone, said process comprising stripping the aqueous medium with steam, wherein said stripping is carried out at a pressure higher than 0.11 MPa. The invention also relates to a process for the preparation of cyclohexanone oxime, which involves stripping at a pressure higher than 0.11 MPa. | ||||||
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