| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 161 | Novel materials containing nitrogen | US327839 | 1973-01-30 | US3965184A | 1976-06-22 | Ronald Eric Banks; Robert Neville Haszeldine |
| Compositions of matter including the structural unit ##EQU1## wherein R.sub. F ' is a divalent polyfluoroalkylene group having a chain length of from 1 to 4 carbon atoms which may be substituted at one or more positions with chloro-or polyfluoroalkyl, chlorofluoroalkyl or polyfluorocycloalkyl groups containing up to six carbon atoms; and R.sub.F is a monovalent straight or branched chain, or cyclic, polyfluoroalkyl group or a chlorofluoroalkyl group containing up to ten carbon atoms and the R.sub.F groups are the same or different or is a divalent polyfluoroalkylene group having a chain length of from 1 to 4 carbon atoms which may be substituted at one or more positions with chloro or polyfluoroalkyl, chlorofluoroalkyl or polyfluorocycloalkyl groups containing up to six carbon atoms and the R.sub.F groups are interconnected to form a cyclic structure. | ||||||
| 162 | Hydroxyguanidine O-carbamates | US37314773 | 1973-06-25 | US3867447A | 1975-02-18 | CHERKOFSKY SAUL CARL |
| Disclosed herein are particular variously substituted 2hydroxyguanidine O-carbamates, useful as antihypertensive agents, made by reacting an hydroxyguanidine with an isocyanate. Exemplary is 1-methyl-1-n-propylhydroxyguanidine O-(N-methyl carbamate).
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| 163 | SAFE AND EFFICIENT PROCESS FOR THE PREPARATION OF CARMUSTINE | EP17158359.4 | 2017-02-28 | EP3214075B1 | 2019-08-21 | TOMASI, Attilio; CANDIANI, Ilaria; CORCELLA, Francesco; CALDARELLI, Francesco Saverio |
| 164 | SAFE AND EFFICIENT PROCESS FOR THE PREPARATION OF CARMUSTINE | EP17158359.4 | 2017-02-28 | EP3214075A3 | 2017-11-29 | TOMASI, Attilio; CANDIANI, Ilaria; CORCELLA, Francesco; CALDARELLI, Francesco Saverio |
The present invention relates to a safe and efficient process for the preparation of carmustine (1) and to useful intermediate compounds of such process and their preparation. Such process employs safe and readily available starting materials under mild reaction conditions and allows for recovery of the product in a good yield and a high purity. For these reasons, such new process is also suitable for plant scale production. Starting materials comprise 2-chloroethylamine hydrochloride (5) and 1,1'-carbonyldiimidazole (4) to afford 1,3-bis(2-chloroethyl)-1-urea (2), which then undergoes nitrosation to give the final product. |
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| 165 | SAFE AND EFFICIENT PROCESS FOR THE PREPARATION OF CARMUSTINE | EP17158359.4 | 2017-02-28 | EP3214075A2 | 2017-09-06 | TOMASI, Attilio; CANDIANI, Ilaria; CORCELLA, Francesco; CALDARELLI, Francesco Saverio |
The present invention relates to a safe and efficient process for the preparation of carmustine (1) and to useful intermediate compounds of such process and their preparation. Such process employs safe and readily available starting materials under mild reaction conditions and allows for recovery of the product in a good yield and a high purity. For these reasons, such new process is also suitable for plant scale production. Starting materials comprise 2-chloroethylamine hydrochloride (5) and 1,1'-carbonyldiimidazole (4) to afford 1,3-bis(2-chloroethyl)-1-urea (2), which then undergoes nitrosation to give the final product. |
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| 166 | NITRIC OXIDE DONATING PROSTAMIDES | EP09742454.3 | 2009-05-11 | EP2274279A1 | 2011-01-19 | BENEDINI, Francesca; BIONDI, Stefano; CHIROLI, Valerio; CHONG, Wesley, Kwan, Mung; DONG, Liming; KRAUSS, Achim, Hans-Pter; NICOLI, Fabio; PRASANNA, Ganesh; VERNIER, William, Francois; YANG, Yi |
| Nitroderivatives of prostaglandins having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension. | ||||||
| 167 | ARYL NITRONE THERAPEUTICS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE | EP99922983.4 | 1999-05-18 | EP1077694B1 | 2004-07-21 | FLITTER, William, D.; GARLAND, William, A.; GREENWOOD-VAN MEERVELD, Beverly; IRWIN, Ian |
| 168 | POLYMERIC ACETOACETANILIDE AZO COLORANTS | EP01984933 | 2001-11-26 | EP1337509A4 | 2004-05-19 | XIA JUSONG; MASON MARY G; MILEY JOHN W; STEPHENS ERIC B; STARKS LEONARD J; STEPHENSON KYLE E |
| This invention related to colorans comprising a chromophore having a single azo acetoacetanilide moiety, wherein said moiety each have at least one poly(oxyalkylene) chain. Such colorants exhibit extremely good base stability and lighfastness, particularly when incorporate within certain media and/or on the surface of certain substrates. These poly(oxyalkylene) chains provide sulubility in different solvents or resins thereby permitting the introduction of such excellent coloring chromophores within diverse media and/or or diverse substrates. Compositions and articles comprising such colorants are provided as are methods for producing such inventive colorants. | ||||||
| 169 | POLYMERIC ACETOACETANILIDE AZO COLORANTS | EP01984933.0 | 2001-11-26 | EP1337509A1 | 2003-08-27 | XIA, Jusong; MASON, Mary, G.; MILEY, John, W.; STEPHENS, Eric, B.; STARKS, Leonard, J.; STEPHENSON, Kyle, E. |
| This invention related to colorans comprising a chromophore having a single azo acetoacetanilide moiety, wherein said moiety each have at least one poly(oxyalkylene) chain. Such colorants exhibit extremely good base stability and lighfastness, particularly when incorporate within certain media and/or on the surface of certain substrates. These poly(oxyalkylene) chains provide sulubility in different solvents or resins thereby permitting the introduction of such excellent coloring chromophores within diverse media and/or or diverse substrates. Compositions and articles comprising such colorants are provided as are methods for producing such inventive colorants. | ||||||
| 170 | NOVEL NITRIC OXIDE-RELEASING AMIDINE- AND ENAMINE-DERIVED DIAZENIUMDIOLATES, COMPOSITIONS AND USES THEREOF AND METHOD OF MAKING SAME | EP98933062.6 | 1998-07-01 | EP1000023A2 | 2000-05-17 | HRABIE, Joseph, A.; KEEFER, Larry, K. |
| The present invention relates to nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions comprising such compounds, methods of using such compounds and compositions, and to a method for the preparation of nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates via the direct reaction of nitric oxide with amidines and enamines, and to a method of converting amines into such compounds. | ||||||
| 171 | N-hydroxy-alpha-amino acids, amides and other derivatives thereof | EP89200193.4 | 1989-01-31 | EP0330247B1 | 1993-07-07 | Kamphuis, Johan; Boesten, Wilhelmus Hubertus Joseph |
| 172 | Amine oxide process | EP88119882.4 | 1988-11-29 | EP0320694A3 | 1990-11-28 | Bauer, Dennis Paul; Summerford, Teresa Kay |
Tert-amine oxides that are substantially free of nitrosamines are made by reacting a tert-amine, e.g., dodecyl dimethylamine, with aqueous hydrogen peroxide in the presence of the synergistic combination of (a) ascorbic acid and (b) a promoter formed from carbon dioxide. |
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| 173 | Fluoroalkyl ether, surface modifying composition and method for modifying surface | EP89117633.1 | 1989-09-25 | EP0361346A2 | 1990-04-04 | Shoji, Mitsuyoshi; Nakakawaji, Takayuki; Ito, Yutaka; Komatsuzaki, Shigeki; Mukoh, Akio |
A solid surface modifying composition comprising a film forming material and a fluoroalkyl ether (-(Rf)̵mCONH-X-NHCO-Y)m (m = 1 or 2; Rf: perfluoropolyether chain;
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| 174 | N-hydroxy-alpha-amino acids, amides and other derivatives thereof | EP89200193.4 | 1989-01-31 | EP0330247A1 | 1989-08-30 | Kamphuis, Johan; Boesten, Wilhelmus Hubertus Joseph |
The invention relates to a process for the preparation of N-hydroxy-alpha-amino acids and the derivatives thereof by reacting a derivative of an alpha-amino acid with an aromatic aldehyde to form a Schiff base, oxidizing the Schiff base to an oxaziridine and converting the oxaziridine into the corresponding N-hydroxy-alpha-amino acid derivative and, if so desired, converting that derivative into the acid or a different derivative, in which an alpha-amino acid amide is used as starting material. |
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| 175 | Inhibitors of RNA guided nucleases and uses thereof | US16346392 | 2017-10-31 | US11787795B2 | 2023-10-17 | Amit Choudhary; Peng Wu; Basudeb Maji; Elisa Franco; Hari K. K. Subramanian |
| Compositions and methods are provided for the inhibition of the function of RNA guided endonucleases, including the identification and use of such inhibitors. | ||||||
| 176 | Lipid compound as well as lipid vector, nucleic acid lipid nanoparticle composition, and pharmaceutical preparation comprising the same | US17873404 | 2022-07-26 | US11786609B2 | 2023-10-17 | Ke Huang; Chaoxuan Jing; Yingwen Li; Yinjia Gao; Yuping Liu; Zhenhua Sun |
| The present disclosure belongs to the technical field of gene therapy, and specifically relates to a series of lipid compounds as well as lipid vectors, nucleic acid lipid nanoparticle compositions, and pharmaceutical preparations containing the same. The compound having the structure of formula (I) provided by the present disclosure may be used in combination with other lipid compounds to prepare a lipid vector, which exhibits pH responsiveness, has high encapsulation efficiency for nucleic acid drugs, and greatly enhances the in-vivo delivery efficiency of nucleic acid drugs. Moreover, it is possible to select lipid compounds with different structures as lipid vectors to adjust the enrichment of nucleic acid drugs in different organs, thereby having good market application prospect. | ||||||
| 177 | Methods for modulating RNA splicing | US16463775 | 2017-11-27 | US11702646B2 | 2023-07-18 | Anuradha Bhattacharyya; Amal Dakka; Kerstin Effenberger; Vijayalakshmi Gabbeta; Wencheng Li; Nikolai Naryshkin; Christopher Trotta; Kari Wiedinger |
| In one aspect, described herein is an intronic recognition element for splicing modifier (iREMS) that can be recognized by a compound provided herein. In another aspect, described herein are methods for modulating the amount of a product of a gene, wherein a precursor RNA transcript transcribed from the gene contains an intronic REMS, and the methods utilizing a compound described herein. More particularly, described herein are methods for modulating the amount of an RNA transcript or protein product encoded by a gene, wherein a precursor RNA transcript transcribed from the gene comprises an intronic REMS, and the methods utilizing a compound described herein. In another aspect, provided herein are artificial gene constructs comprising an intronic REMS, and uses of those artificial gene constructs to modulate protein production. In another aspect, provided herein are methods for altering endogenous genes to comprise an intronic REMS, and the use of a compound described herein to modulate protein produced from such altered endogenous genes. | ||||||
| 178 | LIPID COMPOUND AS WELL AS LIPID VECTOR, NUCLEIC ACID LIPID NANOPARTICLE COMPOSITION, AND PHARMACEUTICAL PREPARATION COMPRISING THE SAME | US17873404 | 2022-07-26 | US20220378938A1 | 2022-12-01 | Ke HUANG; Chaoxuan JING; Yingwen LI; Yinjia GAO; Yuping LIU; Zhenhua SUN |
| The present disclosure belongs to the technical field of gene therapy, and specifically relates to a series of lipid compounds as well as lipid vectors, nucleic acid lipid nanoparticle compositions, and pharmaceutical preparations containing the same. The compound having the structure of formula (I) provided by the present disclosure may be used in combination with other lipid compounds to prepare a lipid vector, which exhibits pH responsiveness, has high encapsulation efficiency for nucleic acid drugs, and greatly enhances the in-vivo delivery efficiency of nucleic acid drugs. Moreover, it is possible to select lipid compounds with different structures as lipid vectors to adjust the enrichment of nucleic acid drugs in different organs, thereby having good market application prospect. | ||||||
| 179 | Synthesis of 1:1:1 co-crystal of 1-cyano-2-(4-cyclopropyl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzene, L-proline and water | US16771717 | 2018-12-17 | US11225500B2 | 2022-01-18 | Matthias Eckhardt; Monika Brink; Frank Himmelsbach; Stefan Sahli; Chutian Shu; Xiao-Jun Wang; Beat Theodor Weber; Bing-Shiou Yang |
| The invention relates to a process for the manufacture of the crystalline compound according to formula (I) comprising the steps (a) deacetylating the final intermediate (FI), (b) forming the crystalline compound according to formula (I) by reacting the deacetylated final intermediate of step (a) with L-proline and water and isolating the final reaction product; processes of manufacturing intermediates thereof; process intermediates and their uses in the processes according to the present invention. | ||||||
| 180 | SYNTHESIS OF 1:1:1 CO-CRYSTAL OF 1-CYANO-2-(4-CYCLOPROPYL-BENZYL)-4-(ß-D-GLUCOPYRANOS-1-YL)-BENZENE, L-PROLINE AND WATER | US16771717 | 2018-12-17 | US20210139520A1 | 2021-05-13 | Matthias ECKHARDT; Monika BRINK; Frank HIMMELSBACH; Stefan SAHLI; Chutian SHU; Xiao-Jun WANG; Beat Theodor WEBER; Bing-Shiou YANG |
| The invention relates to a process for the manufacture of the crystalline compound according to formula (I) comprising the steps (a) deacetylating the final intermediate (FI), (b) forming the crystalline compound according to formula (I) by reacting the deacetylated final intermediate of step (a) with L-proline and water and isolating the final reaction product; processes of manufacturing intermediates thereof; process intermediates and their uses in the processes according to the present invention. | ||||||
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