This invention relates to compounds that inhibit creatine transport and/or creatine kinase, pharmaceutical compositions including such compounds, and methods of utilizing such compounds and compositions for the treatment of cancer.

Compounds comprising a lactam moiety, and a urethane or urea functional group are presented. By a preferred synthesis route, they are prepared using at least one polymerizable compound comprising an isocyanate moiety and reacting it with at least one hydroxyalkyl lactam compound or one aminoalkyl lactam compound. In preferred embodiments the lactam moiety is a pyrrolidone or caprolactam ring, and the polymerizable compound is a functional ized aryl isocyanate. The compounds and homopolymers and non-homopolymers thereof find useful application in a wide variety of arts, including: adhesive, agricultural, biocides, cleaning, coating, electronics, encapsulation, membrane, microelectronics, oilfield, performance chemical, personal care, sealant, and sensor applications.

There is provided an antistatic agent for a polyurethane resin which exhibits sufficient antistatic properties with a smaller addition amount and in which an effective component has no halogen atom. As the effective component of an antistatic agent for a polyurethane resin, there is used an organic salt composed of a dicyanamide anion represented by the following general formula (1) and a cationic component represented by the following general formula (2): wherein R1 represents a linear or branched alkyl group having 1 to 8 carbon atoms, an aryl group or a benzyl group, and R2 and R3 are the same or different and represent H or a linear or branched alkyl group having 1 to 8 carbon atoms.

Disclosed are processes for preparing a protected trifluorothreonine, or salt thereof or carboxylate derivative thereof, the process comprising: dihydroxylation of an alkene to yield a dihydroxyl compound; conversion of the dihydroxyl compound to a monohydroxyl compound; protection of the monohydroxyl compound to yield an azide compound; transformation of the azide compound to yield an amino compound; protection of the amino compound to yield a protected amine compound; and oxidation of the protected amine compound to yield the protected trifluorothreonine. Also disclosed are compounds having the structure: or salt thereof or carboxylate derivative thereof, wherein P² is a hydroxyl protecting group, and wherein P³ is an amine protecting group. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

The present invention provides matriptase inhibitors and compositions thereof useful for treating cancer. Martripase is a trypsin-like serine protease active in the development of cancerous conditions, such as tumors and metastasis of cancer.

The present invention relates to 1,3,5-tricyano-2,4,6-tris(vinyl)benzene derivatives and method for preparing the same. The 1,3,5-tricyano-2,4,6-tris(vinyl)benzene derivatives can be prepared by refluxing 1,3,5-tricyanomesitylene with N-formylamine dimethylacetal or substituted benzaldehyde, or by the Wittig reaction of 1,3,5-tricyano-2,4,6-tris[(diethoxyphosphoryl)methyl]benzene with substituted benzaldehyde. The 1,3,5-tricyano-2,4,6-tris(vinyl)benzene derivatives exhibit large first hyperpolarizability in solution and significant second harmonic generation (SHG) in the powder state, and are useful as optical devices such as electro-optic modulators, optical switch, or the like for treating optical signal in optical communication industry.

This invention is directed to compounds that provide for sustained systemic concentrations of GABA analogs following administration to animals. This invention is also directed to pharmaceutical compositions including and methods using such compounds.

Disclosed herein are compositions comprising a reactive monomer, and, in particular, coating and/or reactive coating compositions. More particularly, compositions containing monomers comprising a lactam moiety, a urethane or urea functional group, and a polymerizable moiety are disclosed.