| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 具有抗癫痫活性的化合物及其在制备抗癫痫药物中的应用 | CN202111341217.5 | 2021-11-12 | CN113968837A | 2022-01-25 | 杨军丽; 高召兵; 郑月明; 孟宪华; 许海燕 |
| 本发明提供了一种具有抗癫痫活性的化合物，该化合物从甘遂中提取分离出来，其中包括2个巨大戟烷型二萜（GS‑22、GS‑54），2个麻风树烷型二萜（GS‑70、GS‑71），1个大戟烷型三萜（GS‑45）。药理学实验显示，上述5个化合物在10微摩尔（µM）给药浓度下可显著性降低海马神经元的放电频率，具有潜在的抗癫痫活性。同时，在此检测浓度下，5种化合物不影响动作电位的幅度、半峰宽和膜电位水平。表明上述5个化合物可用于制备防治癫痫疾病的药物。 | ||||||
| 2 | 从其支化异构体分离未支化烃的方法 | CN200880024245.0 | 2008-06-30 | CN101743214B | 2013-07-17 | M·舒伯特; U·米勒; C·基纳; I·里希特; D·威廉; F·波普洛 |
| 本发明涉及一种从包含未支化烃和至少一种该未支化烃的支化异构体的流体混合物中分离至少一种未支化C4-C20烃的方法，其包括以下步骤：使流体混合物与包含多孔金属有机骨架材料的吸附剂接触，以吸附未支化烃，所述材料包含至少一种与至少一种金属离子配位键合的至少二齿有机化合物，其中所述至少一种至少二齿有机化合物为衍生自至少一种选自吡咯、α-吡啶酮和γ-吡啶酮的杂环的单环、双环或多环体系，所述环体系具有至少两个环中氮且未取代或者带有一个或多个独立地选自卤素、C1-6烷基、苯基、NH2、NH(C1-6烷基)、N(C1-6烷基)2、OH、O-苯基和OC1-6烷基的取代基，其中取代基C1-6烷基和苯基未取代或者带有一个或多个独立地选自卤素、NH2、NH(C1-6烷基)、N(C1-6烷基)2、OH、O-苯基和OC1-6烷基的取代基。本发明还涉及所述多孔金属-有机骨架材料在从其支化异构体中分离未支化烃的方法中的用途。 | ||||||
| 3 | 包括两级分离的联产对二甲苯和间二甲苯的方法 | CN02108251.0 | 2002-03-28 | CN1379007A | 2002-11-13 | P·勒弗莱维; A·梅蒂维尔; G·霍蒂尔 |
| 描述了一种由烃物料共同生产间二甲苯和对二甲苯的方法,该方法包括两个分离步骤。该方法的第一个分离步骤是一个在色谱柱中呈逆流方式的模拟移动床系统,色谱柱包含至少五段,包括连续或间断注入物料、注入解吸剂、取出提取物、提余液和中间提余液。蒸馏提取物,得到纯度至少99.7%的对二甲苯。富含间二甲苯的提余液经蒸馏提取解吸剂,再注入逆流的模拟移动床中,连续地提供提取物和提余液。这两种物流中的一种富含间二甲苯。蒸馏最富含间二甲苯的物流得到纯度99%以上的间二甲苯。 | ||||||
| 4 | 一种分离原油中乙基降金刚烷类化合物的方法和系统 | CN202010353773.3 | 2020-04-29 | CN111635289A | 2020-09-08 | 王萌; 朱光有; 李婧菲 |
| 本发明公开了一种分离原油中乙基降金刚烷类化合物的方法和系统。该方法包括以下步骤：1)将原油进行热解除去乙基降金刚烷类化合物以外的饱和烃化合物，得到热解产物；2)使用硝酸银改性硅胶柱色谱除去热解产物中的芳香烃和极性化合物，得到初步纯化的含有乙基降金刚烷类化合物的组分；3)将步骤2)得到的组分通过反相高压液相色谱进行分离，得到若干亚组分；4)通过气相色谱-质谱联用检测步骤3)得到的亚组分，确定含有乙基降金刚烷类化合物的若干有效亚组分；5)将步骤4)得到的有效亚组分通过形状选择性高压液相色谱进行分离得到各乙基降金刚烷类化合物的纯品。 | ||||||
| 5 | 提纯来自氧化脱氢方法的1,3-丁二烯的方法 | CN201480030343.0 | 2014-03-26 | CN105246864A | 2016-01-13 | S·L·克鲁帕 |
| 提出提纯1,3-丁二烯的方法。该方法用于处理来自氧化脱氢装置的丁二烯料流，在那里将丁烷料流脱氢，产生富丁二烯料流。将富丁二烯料流分馏并通过丁二烯回收装置。将由分馏底部料流回收的其它C4化合物进一步加工以提高丁二烯的收率。 | ||||||
| 6 | 从其支化异构体分离未支化烃的方法 | CN200880024245.0 | 2008-06-30 | CN101743214A | 2010-06-16 | M·舒伯特; U·米勒; C·基纳; I·里希特; D·威廉; F·波普洛 |
| 本发明涉及一种从包含未支化烃和至少一种该未支化烃的支化异构体的流体混合物中分离至少一种未支化C4-C20烃的方法，其包括以下步骤：使流体混合物与包含多孔金属有机骨架材料的吸附剂接触，以吸附未支化烃，所述材料包含至少一种与至少一种金属离子配位键合的至少二齿有机化合物，其中所述至少一种至少二齿有机化合物为衍生自至少一种选自吡咯、α-吡啶酮和γ-吡啶酮的杂环的单环、双环或多环体系，所述环体系具有至少两个环中氮且未取代或者带有一个或多个独立地选自卤素、C1-6烷基、苯基、NH2、NH(C1-6烷基)、N(C1-6烷基)2、OH、O-苯基和OC1-6烷基的取代基，其中取代基C1-6烷基和苯基未取代或者带有一个或多个独立地选自卤素、NH2、NH(C1-6烷基)、N(C1-6烷基)2、OH、O-苯基和OC1-6烷基的取代基。本发明还涉及所述多孔金属-有机骨架材料在从其支化异构体中分离未支化烃的方法中的用途。 | ||||||
| 7 | 用于从一种含有其他的二乙基甲苯(DET)同分异构体的混合物中回收2，6-二乙基甲苯或3，5-二乙基甲苯的色谱分离方法 | CN90106970.1 | 1990-07-09 | CN1058012A | 1992-01-22 | 赫尔曼·A·津伦 |
| 从二乙基甲苯(DET)同分异构体进料混合物中选择性分离3，5-DET和/或2，6-DET的方法。使进料在吸附条件下与一种吸附剂接触，该吸附剂选自：A)钾离子交换的X沸石；B)钠或铜离子交换的X沸石或铜、钠、钡或钙离子交换的Y沸石；C)钡或锂离子或钾和钡离子交换的X沸石或钾、钠、钡或钙离子交换的Y沸石。选择性吸附DET同分异构体的一种或多种，并形成相对于进料中被吸附的同分异构体贫化的提余液，从而除去一种或多种相对不被吸附的同分异构体；最后；使富集吸附剂与一种取代芳烃的解吸剂接触，形成一种相对于进料富集了被吸附同分异构体的萃取液。 | ||||||
| 8 | 具有抗癫痫活性的化合物及其在制备抗癫痫药物中的应用 | CN202111341217.5 | 2021-11-12 | CN113968837B | 2022-09-06 | 杨军丽; 高召兵; 郑月明; 孟宪华; 许海燕 |
| 本发明提供了一种具有抗癫痫活性的化合物，该化合物从甘遂中提取分离出来，其中包括2个巨大戟烷型二萜（GS‑22、GS‑54），2个麻风树烷型二萜（GS‑70、GS‑71），1个大戟烷型三萜（GS‑45）。药理学实验显示，上述5个化合物在10微摩尔（µM）给药浓度下可显著性降低海马神经元的放电频率，具有潜在的抗癫痫活性。同时，在此检测浓度下，5种化合物不影响动作电位的幅度、半峰宽和膜电位水平。表明上述5个化合物可用于制备防治癫痫疾病的药物。 | ||||||
| 9 | 一种分离原油中乙基降金刚烷类化合物的方法和系统 | CN202010353773.3 | 2020-04-29 | CN111635289B | 2022-07-05 | 王萌; 朱光有; 李婧菲 |
| 本发明公开了一种分离原油中乙基降金刚烷类化合物的方法和系统。该方法包括以下步骤：1)将原油进行热解除去乙基降金刚烷类化合物以外的饱和烃化合物，得到热解产物；2)使用硝酸银改性硅胶柱色谱除去热解产物中的芳香烃和极性化合物，得到初步纯化的含有乙基降金刚烷类化合物的组分；3)将步骤2)得到的组分通过反相高压液相色谱进行分离，得到若干亚组分；4)通过气相色谱‑质谱联用检测步骤3)得到的亚组分，确定含有乙基降金刚烷类化合物的若干有效亚组分；5)将步骤4)得到的有效亚组分通过形状选择性高压液相色谱进行分离得到各乙基降金刚烷类化合物的纯品。 | ||||||
| 10 | 提纯来自氧化脱氢方法的1,3-丁二烯的方法 | CN201480030343.0 | 2014-03-26 | CN105246864B | 2018-03-23 | S·L·克鲁帕 |
| 提出提纯1,3‑丁二烯的方法。该方法用于处理来自氧化脱氢装置的丁二烯料流，在那里将丁烷料流脱氢，产生富丁二烯料流。将富丁二烯料流分馏并通过丁二烯回收装置。将由分馏底部料流回收的其它C4化合物进一步加工以提高丁二烯的收率。 | ||||||
| 11 | 大型色谱法生产高纯乙烯的技术 | CN201010210229.X | 2010-06-28 | CN101863730A | 2010-10-20 | 李中元 |
| 本发明公开了一种大型色谱法生产高纯乙烯的技术，主要由原料贮罐、进样器、分离柱、分析控制器、自动阀、1#冷阱、2#冷阱按其系统功能通过连接管线组装一体而构成。设计合理，使用方便，是理想的高纯乙烯制备工艺技术。 | ||||||
| 12 | 包括两级分离的联产对二甲苯和间二甲苯的方法 | CN02108251.0 | 2002-03-28 | CN1243701C | 2006-03-01 | P·勒弗莱维; A·梅蒂维尔; G·霍蒂尔 |
| 描述了一种由烃物料共同生产间二甲苯和对二甲苯的方法，该方法包括两个分离步骤。该方法的第一个分离步骤是一个在色谱柱中呈逆流方式的模拟移动床系统，色谱柱包含至少五段，包括连续或间断注入物料、注入解吸剂、取出提取物、提余液和中间提余液。蒸馏提取物，得到纯度至少99.7%的对二甲苯。富含间二甲苯的提余液经蒸馏提取解吸剂，再注入逆流的模拟移动床中，连续地提供提取物和提余液。这两种物流中的一种富含间二甲苯。蒸馏最富含间二甲苯的物流得到纯度99%以上的间二甲苯。 | ||||||
| 13 | Diamond in microelectronics Ido-containing materials | JP2002558328 | 2002-01-17 | JP2004526305A | 2004-08-26 | カールソン、ロバート、エム; ダール、ジェレミー、イー; リウ、シェンガオ |
| Novel uses of diamondoid-containing materials in the field of microelectronics are disclosed. Embodiments include, but are not limited to, thermally conductive films in integrated circuit packaging, low-k dielectric layers in integrated circuit multilevel interconnects, thermally conductive adhesive films, thermally conductive films in thermoelectric cooling devices, passivation films for integrated circuit devices (ICs), and field emission cathodes. The diamondoids employed in the present invention may be selected from lower diamondoids, as well as the newly provided higher diamondoids, including substituted and unsubstituted diamondoids. The higher diamondoids include tetramantane, pentamantane, hexamantane, heptamantane, octamantane, nonamantane, decamantane, and undecamantane. The diamondoid-containing material may be fabricated as a diamondoid-containing polymer, a diamondoid-containing sintered ceramic, a diamondoid ceramic composite, a CVD diamondoid film, a self-assembled diamondoid film, and a diamondoid-fullerene composite. | ||||||
| 14 | Polymerizable luxury diamond-like bodies derivative | JP2002557884 | 2002-01-17 | JP2004517989A | 2004-06-17 | カールソン、ロバート、エム; ダール、ジェレミー、イー; リウ、シェンガオ |
| 重合反応に参加することができる高級ダイヤモンド様体誘導体が、これらの誘導体への中間体として、これらの誘導体から形成された重合体として、そしてそれらの重合体を造るための方法として開示される。 | ||||||
| 15 | Separation of 2,6-dialkylnaphthalene | JP13030990 | 1990-05-22 | JPH0426635A | 1992-01-29 | OTAKE MASAYUKI; MASUYAMA TETSUO; NAKANISHI AKIO; ASAHI YOSHIO; YAMAGUCHI TAKAHIRO |
| PURPOSE: To separate a 2,6-dialkylnaphthalene from a dialkylnaphthalene isomer mixture, to isomerize a raw material oil having reduced concentration of 2,6- dialkylnaphthalene, to raise concentration of 2,6-dialkylnaphthalene, to partially remove the reaction product and to circulate the resulting substance prepared by eliminating part of components except dialkylnaphthalene from the isomerized reaction product. CONSTITUTION: 2,6-Dialkylnaphthalene is separated from a raw material oil comprising a dialkylnaphthalene isomer mixture as a main component by chromatography separation and/or crystallization separation, the raw material oil component is isomerized in the presence of a solid acid catalyst (e.g. H-ZSM-5 type zeolite) in a hydrogen gas flow to increase concentration of 2,6-dialkylnaphthalene to a composition close to concentration of thermodynamic equilibrium and a substance prepared by removing part of components except dialkylnaphthalene from the isomerized reaction product is circulated to the initial process. By the above-mentioned process, high-purity 2,6- dialkylnaphthalene having ≥99% purity can be efficiently separated. COPYRIGHT: (C)1992,JPO&Japio | ||||||
| 16 | Diamond in microelectronics Ido-containing materials | JP2002558328 | 2002-01-17 | JP4178030B2 | 2008-11-12 | カールソン、ロバート、エム; ダール、ジェレミー、イー; リウ、シェンガオ |
| Novel uses of diamondoid-containing materials in the field of microelectronics are disclosed. Embodiments include, but are not limited to, thermally conductive films in integrated circuit packaging, low-k dielectric layers in integrated circuit multilevel interconnects, thermally conductive adhesive films, thermally conductive films in thermoelectric cooling devices, passivation films for integrated circuit devices (ICs), and field emission cathodes. The diamondoids employed in the present invention may be selected from lower diamondoids, as well as the newly provided higher diamondoids, including substituted and unsubstituted diamondoids. The higher diamondoids include tetramantane, pentamantane, hexamantane, heptamantane, octamantane, nonamantane, decamantane, and undecamantane. The diamondoid-containing material may be fabricated as a diamondoid-containing polymer, a diamondoid-containing sintered ceramic, a diamondoid ceramic composite, a CVD diamondoid film, a self-assembled diamondoid film, and a diamondoid-fullerene composite. | ||||||
| 17 | Diamond-containing material in microelectronics | JP2008121457 | 2008-05-07 | JP2008252107A | 2008-10-16 | DAHL JEREMY E; CARLSON ROBERT M; LIU SHENGGAO |
| <P>PROBLEM TO BE SOLVED: To provide a field emission element containing a thermally conductive film of integrated circuit package, a low-k dielectric layer of integrated circuit multilevel wiring, a heat conductive adhesion film, a heat conductive film of thermoelectric cooling element, a passivation film for integrated circuit elements (ICs) and a field-emission cathode. <P>SOLUTION: A diamondoid includes a low-class diamondoid, a recently provided high class diamondoid, and substituted and non-substituted diamondoid. The diamondoid containing material may be processed as a polymer containing diamondoid, a sintered ceramics containing diamondoid, a diamondoid-ceramic complex, a CVD diamondoid film, a self-assembled diamondoid film, and a diamondoid-fullerene complex. The system paves the way for new applications of the diamondoid containing material in microelectronics. <P>COPYRIGHT: (C)2009,JPO&INPIT | ||||||
| 18 | Collection of dimethyl ether from liquid phase olefinic c3-c5 supplying raw material | JP29684886 | 1986-12-15 | JPS62215539A | 1987-09-22 | MOEZU MOHAMEDARI NAGUJI; JIAKOMO KORUBINI |
| 19 | Adsorbent for olefin and method of selectively removing olefin by using said adsorber | JP12347885 | 1985-06-06 | JPS6128449A | 1986-02-08 | EDOWARUDO GERUMAIN BOOREN; RIHIYARUTO BEIJIERUSUBERUGEN F |
| Adsorption material for olefins; gas chromatography column; method of selectively removing olefins from a mixture of hydrocarbons. …This invention relates to an adsorption material for olefins, a gas chromatography column and a method for removing olefins from a mixture with saturated hydrocarbons by gas chromatography. The adsorption material according to the invention is a thermostable, macroporous resin having strongly acid ion exchange groups to which silver ions are linked. The resin has an average pore diameter of 10-100 nm, an internal surface area of 10-100 m<2>/g and 5-15% cross-linking. | ||||||
| 20 | JPS5116909B1 - | JP10692870 | 1970-12-04 | JPS5116909B1 | 1976-05-28 | |
| A class of novel crystalline aluminosilicates generally identified as ZSM-5 type and having unique molecular sieving properties are utilized as selective sorbents in a chromatographic process. The effective portals in these zeolites are apparently elliptically shaped with effective major and minor axis of about 7.0 +/- 0.7A and 5.0 +/- 0.5A, respectively. This unique shape is utilized to provide "keyhole" molecular sieving action which is particularly useful for separating specific members of closely-related chemical compounds. A preferred embodiment is the selective separation of disubstituted hydrocarbons such as dialkyl aromatics. The process of this invention is particularly useful for separating C8 aromatic mixtures. A particularly preferred embodiment is the separation of p-xylene from a mixture of the same with o-xylene and/or m-xylene and/or ethylbenzene. | ||||||
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