| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 61 | METHOD FOR PRODUCING NITROXYL COMPOUNDS OF SECONDARY AMINES | PCT/EP1999/008170 | 1999-10-28 | WO00026189A1 | 2000-05-11 | |
| The invention relates to a method for producing nitroxyl compounds of secondary amines which do not carry any hydrogen atoms on the alpha -carbon atoms. According to said method, amines of this type are oxidised with hydrogen peroxide in the presence of an acidic substance. | ||||||
| 62 | TRIARYLMETHYL FREE RADICALS AS IMAGE ENHANCING AGENTS | PCT/GB1998/000672 | 1998-03-06 | WO98039277A1 | 1998-09-11 | |
| Novel triarylmethyl free radicals, their use as image enhancing agents in MRI, in particular to their use in Overhauser enhanced MRI of a sample for determining oxygen concentration of said sample. | ||||||
| 63 | METHOD AND DEVICE TO ACHIEVE RADICAL GAS PHASE REACTIONS | PCT/EP0205485 | 2002-05-17 | WO02094743A3 | 2003-03-06 | HEINICHEN HOLGER; HEYL ANDREAS; APPEL JOERG |
| The object of the invention is to improve the manner in which radical gas phase reactions are carried out so that the temperature of the reaction can be kept at the lowest possible level and an adequate amount of radicals is available for the reaction. In order to achieve this, one or several educts (A) are placed in a reactor (1) where they react at an initial temperature in the presence of one or several radical species (R*) to form one or more products (P); the radical species (R*) are produced outside the reactor (1) at a second temperature (T2) which is higher than the first (T1), by thermal decomposition, using radical formers (RB), whereupon they are fed into the reactor (1) with the educts (A) contained therein. | ||||||
| 64 | METHOD FOR PREPARING DOLLAR G(B)-PHOSPHORUS NITROXIDE RADICALS | PCT/FR2001/003876 | 2001-12-07 | WO02048159A1 | 2002-06-20 | |
| The invention concerns a method for preparing beta -phosphorus nitroxide radicals which consists in first preparing an aminophosphonate by reacting a carbonyl compound, a primary amine and a phosphorus compound in the presence of a Lewis acid, then in oxidising said raw aminophosphonate using non-halogenated organic peracids in an organic two-phase water/solvent medium with a buffered aqueous phase with a pH ranging between 5 and 12. | ||||||
| 65 | Use of free radicals in ESR and ESREMR imaging | US477568 | 1995-06-07 | US5827501A | 1998-10-27 | Mikkel J.o slashed.rgensen; Frode Rise; Sven Andersson; Torsten Almen; Arne Aabye; Lars-Goran Wistrand; H.ang.kan Wikstrom; Klaes Golman; Rolf Servin; Peter Michelsen |
| The present invention relates to a method of generating an electron spin resonance enhanced magnetic resonance image of a sample which comprises introducing into the sample a magnetic resonance signal enhancing amount of a free radical and generating an enhanced electron spin resonance image of the sample. The method comprises using as the free radical an inert triarylmethyl free radical, wherein each aryl moiety of said triarylmethyl radical, which may be identical or different, comprises an optionally substituted 6-membered carbocyclic or thienyl ring. The invention also relates to the use of trityls in ESR imaging. | ||||||
| 66 | Free Radicals | US467273 | 1995-06-06 | US5728370A | 1998-03-17 | Sven Andersson; Finn Radner; Anna Rydbeck; Rolf Servin; Lars-Goran Wistrand |
| The present invention relates to certain novel triaryl methyl free radicals and their use as image enhancing agents in magnetic resonance imaging (MRI) as well as to contrast media containing such radicals and to the use of such radicals and their non-radical precursors in the manufacture of MRI contrast media. | ||||||
| 67 | Process for the preparation of N-oxyl hindered amine esters | US298898 | 1994-08-31 | US5574163A | 1996-11-12 | John J. Luzzi |
| When a tetraalkyl orthotitanate transesterification catalyst is used in the preparation of N-oxyl hindered amine esters, the N-oxyl compound is obtained in excellent yield and purity when moderate temperatures (90.degree.-130.degree. C.) and an aliphatic hydrocarbon solvent are used. The N-oxyl compounds are light stabilizers and also inhibitors for preventing the premature polymerization of ethylenically unsaturated monomers. | ||||||
| 68 | Free radicals | US220522 | 1994-03-31 | US5530140A | 1996-06-25 | Sven Andersson; Finn Radner; Anna Rydbeek; Rolf Servin; Lars-Goran Wistrand |
| The invention provides novel persistent free radicals useful in Overhauser MRI being triarylmethyl radicals having as at least one aryl group a group of formula ##STR1## (wherein each X which may be the same or different is an oxygen or sulphur atom or a group CO or S(O).sub.n, (where n is 1 to 3) with the proviso that at least one group X is a sulphur atom or a S(O).sub.n group; R.sup.1 is a hydrogen atom or group of formula --M, --XM, --X--Ar.sup.2, or --Ar.sup.2 where M is a water solubilizing group, and Ar.sup.2 represents a 5-10 membered aromatic ring optionally substituted by a water solubilizing group M; and each of the groups R.sup.7, which may be the same or different, is a hydrogen atom, or a hydrocarbon group or a water solubilizing group M, or two groups R.sup.7 together with the atom to which they are bound represent a carbonyl group or a 5 to 8 membered cycloalkylidene, mono- or di-oxacycloalkylidene, mono- or di-azacycloalkylidene or mono- or di-thiacycloalkylidene group optionally with the ring attachment carbon replaced by a silicon atom, and R.sup.7 where it is other than hydrogen, is optionally substituted by a hydroxyl group, an optionally alkoxylated, optionally hydroxylated acyloxy or alkyl group or a water solubilizing group M)). The novel radicals have good stability, long relaxation times and good relaxivity. | ||||||
| 69 | Persistent perfluoroalkyl free radicals useful as polymerization catalyst | US482359 | 1983-04-05 | US4626608A | 1986-12-02 | Kirby V. Scherer, Jr.; Taizo Ono; Kouichi Yamanouchi |
| Novel persistent perfluorinated free radicals are disclosed, which upon thermal decomposition yield free radicals which can be used to polymerize polymerizable monomers containing ethylenic unsaturation. | ||||||
| 70 | Photochemical reactions for commercial synthesis | US442181 | 1982-11-16 | US4525255A | 1985-06-25 | James E. Guillet |
| Photochemical reactions are conducted using floating polymer beads on the surface of a moving body of water. The polymer bead is impregnated with a reactant, floated on the water in direct sunlight so as to expose the reactant to solar radiation, collected at a downstream location, treated to remove product from the polymer, and then the bead can be recycled. The process can be used to collect and store solar energy in chemical form, or for conducting photochemical synthesis to produce useful chemical products. | ||||||
| 71 | Stable free radical nitroxides | US3422144D | 1965-04-27 | US3422144A | 1969-01-14 | HOFFMANN ARTHUR KENTARO; ABRAHAM ERNESTINE GELBLUM |
| 72 | Method of generating free acyl radicals by irradiation of acyl derivatives of dithiocarboxylic acids | US26795163 | 1963-03-26 | US3276982A | 1966-10-04 | RICHARD BARTON DEREK HAROLD |
| 73 | 디메틸 테레프탈레이트 제조 공정으로부터 발생하는 부산물로부터 고순도의 메틸-4-포밀벤조에이트의 정제방법 | KR1020110003616 | 2011-01-13 | KR101263405B1 | 2013-05-10 | 김석찬; 김우선; 이윤아; 류영; 정효진 |
| 본발명은 DMT(디메틸테레프탈레이트) 제조공정에서발생하는부산물로부터더욱고순도의 MFB를정제하는방법으로, (a) DMT(디메틸테레프탈레이트)의제조과정에서생성되며, 메틸포밀벤조에이트를함유하는반응부산물에알코올을첨가하고이를여과하는단계; (b) 상기여과후 여액에 (i) 히드록시아민또는히드록시아민의무기산염및 (ii) 알칼리성분을첨가하여옥심화반응을통하여여액내의메틸포밀벤조에이트를메틸 4-히드록시이미노벤조에이트로전환시키고이를여과하는단계; (c) 상기생성된메틸 4-히드록시이미노벤조에이트혼합물을톨루엔또는메틸렌클로라이드에용해시키는단계; 및 (d) 상기혼합물에산을첨가하는단계를포함하는더욱고순도로메틸포밀벤조에이트를정제하는방법을제공한다. | ||||||
| 74 | 고순도 트리멜리트산의 제조법 | KR1020107021945 | 2009-04-07 | KR1020110013359A | 2011-02-09 | 가와이다케시; 야부노마사시 |
| 디메틸벤즈알데히드 및/또는 그의 산화 유도체를 촉매를 함유하는 물 용매 중에서 분자상 산소에 의해 액상 산화를 행하여 트리멜리트산을 제조하는 방법에 있어서, 원료로서 3,4-디메틸벤즈알데히드 및/또는 3,4-디메틸벤조산을 사용하고, 촉매로서 물 용매 100 중량부에 대하여 코발트, 망간 및 니켈로 이루어진 군으로부터 선택되는 1종 이상의 금속 0.05~1 중량부, 금속 철 및/또는 수용성 철염에서 얻어지는 철 0.0001~0.0015 중량부, 브롬 1~5 중량부를 함유하는 촉매를 이용하여 200~250℃의 온도에서 액상 산화하는 고순도 트리멜리트산의 제조법을 제공한다. 본 발명의 방법에 의하면 산화 반응 중간체나 부가 화합물, 유기 브롬 화합물 등의 부생성물이 극히 적은 고품질, 고순도의 트리멜리트산을 고수율로 얻을 수 있고, 또 촉매로 사용하는 브롬의 잔존율이 높아 제조 비용이 삭감된다. | ||||||
| 75 | Heterogeneous photo-initiators, photopolymerizable compositions and their use | US983052 | 1998-01-15 | US6048667A | 2000-04-11 | Sameer Hosam Eldin; Peter Grieshaber; Fran.cedilla.ois Rime; Kurt Dietliker |
| Heterogeneous photoinitiator in microparticle form, which consists of a finely divided substrate material to which identical or different photoinitiators are covalently bonded. The photoinitiators are suitable for the radiation-induced polymerization of photopolymerizable or photocrosslinkable monomers for the production of moldings, protective coats and relief images. | ||||||
| 76 | Free radicals | US882147 | 1997-06-25 | US6013810A | 2000-01-11 | Mikkel Thaning |
| Novel triarylmethyl free radicals, their use as image enhancing agents in MRI, in particular to their use in Overhauser enhanced MRI of a sample for determining oxygen concentration of said sample. | ||||||
| 77 | Use of persistent heterocyclic free-radicals in magnetic resonance imaging | US190045 | 1994-03-18 | US5435991A | 1995-07-25 | Klaes Golman; Sven Andersson; Frode Rise; Lars-Goran Wistrand; Hakan Wikstrom |
| The present invention provides the use of a persistent .pi.-system free radical for the manufacture of a contrast medium for use in magnetic resonance imaging, wherein the electron delocalising .pi.-system of said radical comprises at least one homo or heterocyclic ring, said radical being other than the chloranil semiquinone anion radical or a trityl radical. Also provided are magnetic resonance imaging contrast media containing and methods using such radicals. | ||||||
| 78 | Selective isotopic labeling of spin labels for electron spin resonance spectroscopy | US227793 | 1988-08-03 | US5431901A | 1995-07-11 | Howard J. Halpern; Beverly A. Teicher |
| Selective isotopic-labeling of spin label compounds, used in electron spin resonance spectroscopy to detect, measure and monitor the presence of paramagnetic species, increases the sensitivity of the electron spin resonance technique in assays for paramagnetic species, such as the determination of oxygen tension in solution or in a biological sample, like a living organism. Spin label compounds, such as nitroxides, like 3-carbamoyl-2,2,5,5-tetramethyl-3-pyrroline-1-yloxyl (CTPO), are selectively, but not completely, isotopically-labeled, such as partially deuterated, to increase the sensitivity and reliability of assays employing electron spin resonance spectroscopic measurements. | ||||||
| 79 | Procedure for the preparation of nitroxyl radicals of sterically hindered amines | US800039 | 1991-11-29 | US5218116A | 1993-06-08 | Carlo Neri; Silvestro Costanzi; Rosa M. Riva; Mariangela Angaroni |
| Procedure for the preparation of nitroxyl radicals of sterically hindered amines, consisting of the reaction of amines with hydrogen peroxide in the presence of a titanium containing catalyst, particularly in the presence of titanium silicalites.The catalyst can be recovered at the end of the reaction and recycled. | ||||||
| 80 | Photolytic process for the formation of carbon-containing free radicals and its applications to free radical polymerization in particular | US643178 | 1984-08-22 | US4668356A | 1987-05-26 | Derek H. R. Barton; David Crich; William B. Motherwell |
| Process for the formation of carbon-containing free radicals R., which optionally include functional groups, wherein thermal and/or photochemical energy is supplied to a thiocarbonyl-containing ester corresponding to the general formula (I): ##STR1## in which: R denotes a saturated or unsaturated, linear or branched, aliphatic or aromatic, acyclic or alternatively mono- or poly-cyclic or mono- or poly-heterocyclic, carbon-containing radical which in addition can optionally include functional groups;R' and R" denote, independently of each other, an alkyl, alkenyl, aryl, aralkyl or alkaryl radical, or alternatively form together a 5- or 6-membered nitrogen-containing heterocycle which can also contain an additional heteroatom chosen from nitrogen and sulfur and which can optionally be substituted or fused to at least one other aliphatic or aromatic ring;R.sub.1 and R.sub.2 denote, independently of each other, a hydrogen atom or a lower alkyl radical, andn is an integer equal to 0, 1, 2 or 3. | ||||||
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