| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 101 | 3 차 알콜의 제조 방법 | KR1020107003156 | 2008-07-10 | KR1020100046007A | 2010-05-04 | 맥가리티욘; 도조프란시스 |
| Tertiary alcohols are prepared by reacting carboxylic esters with Grignard reagents in ethereal solvents in the presence of lanthanum trichloride and lithium chloride. The method is particularly suitable for the production of (α)-α-[3-[(1)-2-(7-chloro-2-quino-linyl)ethenyl]phenyl]-2-(1-hydroxy-1-methylethyl)benzenepropanol of formula (A) which is an intermediate in the production of montelukast. | ||||||
| 102 | 비페닐 유도체의 제조 방법 | KR1020097003605 | 2007-10-12 | KR1020090066267A | 2009-06-23 | 하야시타미오; 나카타니지로 |
| Disclosed is an excellently productive method for producing a biphenyl derivative with a commercially high yield by using a raw material which is low in cost and toxicity. Specifically disclosed is a method for producing a biphenyl derivative represented by the general formula (1) below, which is characterized in that a chlorine atom in a benzene derivative represented by the general formula (2) below is reacted with magnesium metal and converted into a Grignard reagent, and then the Grignard reagent is subjected to a coupling reaction in the presence of a catalyst and dichloropropane. (In the formulae, A represents at least one selected from the group consisting of alkyl groups, alkoxy groups, alkoxymethyl groups, a vinyl group, a phenyl group and chlorine; and n represents an integer of 1-4.) | ||||||
| 103 | 그리냐르 화합물의 입체선택적 제조 방법 및 그의 용도 | KR1020017000264 | 1999-07-02 | KR1020010053425A | 2001-06-25 | 보이몽드,라우헤; 로트렌데르,마리오; 까이에,제라르; 크노헬,파울 |
| 본 발명은 화학식 Ⅰ의 그리냐르 화합물, 화학식 Ⅰa의 중합체-결합된 화합물의 입체선택적 제조 방법, 물질 표준 라이브러리의 제조에 있어서 그의 용도 및 입체선택적 화학 합성에 있어서 화학식 Ⅰ 및 Ⅰa의 화합물의 용도에 관한 것이다. | ||||||
| 104 | Intermediates for the vitamin A synthesis | US17676077 | 2022-02-18 | US11851404B2 | 2023-12-26 | Raphael Beumer; Werner Bonrath; Marc-André Mueller; Bettina Wüestenberg |
| Processes for synthesizing new compounds that may usefully be employed in organic synthesis, especially in the synthesis of vitamin A or β-carotene and derivatives thereof, e.g. canthaxanthin, astaxanthin or zeaxanthin are disclosed. The new compounds are especially useful as intermediates (building blocks) in the synthesis of vitamin A or β-carotene, preferably vitamin A. | ||||||
| 105 | Process for preparation of palbociclib | US16314972 | 2017-07-03 | US10807978B2 | 2020-10-20 | Andiappan Murugan; Vipinkumar Shriram Kabra; Chinna Saida Reddy Gade; Rama Rao Gondu; Shravankumar Chandrashekar; Krishnamoorthy Pasupathy; Anandan Kalaiselvan |
| The present application relates to a process for the preparation of crystalline form A of palbociclib having specific surface area more than 2 m2/g comprising one-pot process for the preparation of compound of formula (IV). The present application further relates to the preparation of acid-addition salts of palbociclib and their use for the synthesis of crystalline form A of palbociclib having specific surface area more than 2 m2/g. | ||||||
| 106 | PROCESS FOR PREPARATION OF PALBOCICLIB | US16314972 | 2017-07-03 | US20190241561A1 | 2019-08-08 | Andiappan MURUGAN; Vipinkumar Shriram KABRA; Chinna Saida Reddy GADE; Rama Rao GONDU; Shravankumar CHANDRASHEKAR; Krishnamoorthy PASUPATHY; Anandan KALAISELVAN |
| The present application relates to a process for the preparation of crystalline form A of palbociclib having specific surface area more than 2 m2/g comprising one-pot process for the preparation of compound of formula (IV). The present application further relates to the preparation of acid-addition salts of palbociclib and their use for the synthesis of crystalline form A of palbociclib having specific surface area more than 2 m2/g. | ||||||
| 107 | Tricyclic analogues, preparation method and uses thereof | US15556932 | 2016-03-03 | US10278962B2 | 2019-05-07 | Fajun Nan; Boliang Li; Yang Zhan; Xiaowei Zhang; Ying Xiong; Xichan Hu; Yangming Zhang |
| The present invention relates to a series of analogs of natural product Pyripyropene A represented by general formula I and a preparation method and use thereof. More particularly, the present invention relates to analogs of the natural product Pyripyropene A, a preparation method and use thereof as the acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors for the treatment of cardiovascular diseases such as atherosclerosis and the like. | ||||||
| 108 | Method for preparing citalopram diol intermediate | US15580517 | 2015-06-09 | US10227293B2 | 2019-03-12 | Zunjun Liang; Weifeng Xiao; Caihua Peng; Wenfeng Huang; Guoliang Tu |
| The present invention relates to a method for preparing a citalopram diol represented by formula IV, comprising the following steps: in the existence of an auxiliary reagent of metal salt, allowing 5-cyanophthalide to sequentially subjected to Grignard addition reactions with p-fluorophenyl magnesium halide and N, N-dimethylaminopropyl magnesium halide in an organic solvent; and after the reactions are completed, performing hydrolysis and separation to obtain citalopram diol represented by formula IV. In the present invention, by adding an auxiliary reagent of metal salt, the activity and the selectivity of the Grignard reactions are remarkably improved, and the reaction yield is obviously enhanced. | ||||||
| 109 | Process for the preparation of triazines | US15571113 | 2016-05-12 | US10183916B2 | 2019-01-22 | Nadine Greiner; Sandro Schmid; René Tobias Stemmler |
| The invention relates to an improved process for the manufacture of bis-resorcinyl triazines of formula (I) wherein R1 is a C1C18alkyl group or C2-C18alkenyl group as well as the respective alkyl substituted bis-resorcinyl derivatives of formula (II) wherein R1 is a C1-C18alkyl group or C2-C18alkenyl group and R2 and R3 are independently of each other a C1-C18alkyl group or a C2-C18alkenyl group. | ||||||
| 110 | PROCESS FOR THE PREPARATION OF TRIAZINES | US15571113 | 2016-05-12 | US20180170886A1 | 2018-06-21 | Nadine GREINER; Sandro SCHMID; René Tobias STEMMLER |
| The invention relates to an improved process for the manufacture of bis-resorcinyl triazines of formula (I) wherein R1 is a C1C18alkyl group or C2-C18alkenyl group as well as the respective alkyl substituted bis-resorcinyl derivatives of formula (II) wherein R1 is a C1-C18alkyl group or C2-C18alkenyl group and R2 and R3 are independently of each other a C1-C18alkyl group or a C2-C18alkenyl group. | ||||||
| 111 | Method for allylating and vinylating aryl, heteroaryl, alkyl, and alkene halogenides using transition metal catalysis | US13577278 | 2011-02-01 | US09309188B2 | 2016-04-12 | Matthias Gotta; Bernd Wilhelm Lehnemann; Waldemar Maximilian Czaplik; Matthias Mayer; Axel Jacobi Von Wangelin |
| What is described is a process for preparing organic compounds of the general formula (I) R—R′ (I) by converting a corresponding compound of the general formula (II) R—X (II) in which X is fluorine, chlorine, bromine or iodine to an organomagnesium compound of the general formula (III) [M+]n[RmMgXkY1] (III) wherein compounds of the formula (III) are reacted with a compound of the general formula (IV) characterized in that the reaction of (III) with (IV) is performed in the presence of a) catalytic amounts of an iron compound, based on the compound of the general formula (II), and optionally in the presence of b) a nitrogen-, oxygen- and/or phosphorus-containing additive in a catalytic or stoichiometric amount, based on the compound of the general formula (II). | ||||||
| 112 | Process of preparing Grignard reagent | US14083842 | 2013-11-19 | US09145341B2 | 2015-09-29 | Yair Ein-Eli; Daniel Luder; Alexander Kraytsberg |
| A novel process of preparing a Grignard reagent is disclosed. The process is effected by electrochemically reacting a Grignard precursor with an electrode which comprises a metal for forming the Grignard reagent, in the presence an electrolyte solution that comprises a room temperature ionic liquid (RTIL). Electrochemical cells and systems for performing the process, and uses thereof in various applications are also disclosed. | ||||||
| 113 | PROCESS OF PREPARING GRIGNARD REAGENT | US14083842 | 2013-11-19 | US20140142332A1 | 2014-05-22 | Yair Ein-Eli; Daniel Luder; Alexander Kraytsberg |
| A novel process of preparing a Grignard reagent is disclosed. The process is effected by electrochemically reacting a Grignard precursor with an electrode which comprises a metal for forming the Grignard reagent, in the presence an electrolyte solution that comprises a room temperature ionic liquid (RTIL). Electrochemical cells and systems for performing the process, and uses thereof in various applications are also disclosed. | ||||||
| 114 | Low protonation constant hydroxy acids | US12160760 | 2006-12-27 | US08431748B2 | 2013-04-30 | Nicola Rehnberg; Curt Persson |
| The present invention relates to a hydroxy-sulphureous acid, to a method for preparation of the hydroxysulphureous acid and to products based on said hydroxysulphureous acid, to methods for preparation of said products and to use of said products, wherein said hydroxysulphureous acid is used as building blocks for polymer systems, e g aqueous polymer systems such as inks, coatings, and adhesives. | ||||||
| 115 | Process for preparing unsymmetrical biaryls and alkylated aromatic compounds from arylnitriles | US10202483 | 2002-07-23 | US06962999B2 | 2005-11-08 | Joseph A. Miller |
| Methods are provided for the construction of unsymmetrical biaryl compounds and alkylated aromatic compounds from arylnitriles using a nickel or palladium catalyzed coupling in which the catalyst has at least one phosphine or phosphite ligand. | ||||||
| 116 | Method of preparing organomagnesium compounds | US11097707 | 2005-04-01 | US20050218532A1 | 2005-10-06 | Paul Knochel; Arkady Krasovskiy |
| The present invention is directed to a reagent for use in the preparation of organomagnesium compounds as well as to a method of preparing such organomagnesium compounds. The present invention furthermore provides a method of preparing functionalized or unfunctionalized organic compounds as well as the use of the reagents of the present invention in the preparation of organometallic compounds and their reaction with electrophiles. Finally, the present invention is directed to the use of lithium salts—LiY in the preparation of organometallic compounds and their reactions with electrophiles and to an organometallic compound which is obtainable by the disclosed method. | ||||||
| 117 | Solvents containing cycloakyl alkyl ethers and process for production of the ethers | US10481340 | 2002-06-27 | US20050065060A1 | 2005-03-24 | Idan Kin; Genichi Ohta; Kazuo Teraishi; Kiyoshi Watanabe |
| The present inventions are (A) a solvent comprising at least one cycloalkyl alkyl ether (1) represented by the general formula: R1-O-R2 (wherein R1 is cyclopentyl or the like; and R2 is C1-10 alkyl or the like); (B) a method of preparations the ethers (1) characterized by reacting an alicyclic olefin with an alcohol in the presence of an acid ion-exchange resin having a water content of 5 wt % or less. The solvent is useful as cleaning solvent for electronic components, precision machinery components or the like, reaction solvent using various chemical reactions, extraction solvent for extracting objective organic substances, solvent or remover for electronic and electrical materials, and so on. The process enables industrially advantageous production of the objective cycloalkyl alkyl ethers (1). | ||||||
| 118 | Method of storing active zero valent zinc metal | US432828 | 1995-05-02 | US5964919A | 1999-10-12 | Reuben D. Rieke |
| A novel zerovalent zinc species and an organozinc reagent are disclosed. The zerovalent zinc species is directly produced by reaction of a reducing agent on a zinc salt, preferably Zn(CN).sub.2. The organozinc regent results from the reaction of the zerovalent zinc species and an organic compound having one or more stable anionic leaving groups. These organozinc reagents include a wide spectrum of functional groups in the organic radical, and are useful in a variety of reactions schemes. | ||||||
| 119 | Process for preparing biaryl compounds | US966335 | 1997-11-07 | US5922898A | 1999-07-13 | Joseph Arthur Miller; Robert Patrick Farrell |
| The present invention provides a process for preparing biaryl compounds comprising reacting an arylmetal reagent selected from arylmagnesium reagents and aryllithium reagents with an arylhalide in the presence of a catalyst system comprising a catalyst selected from nickel catalysts and palladium catalysts and a cocatalyst selected from zinc cocatalysts and cadmium cocatalysts. The present invention specifically provides a process for the preparation of 2-(4'-methylphenyl)benzonitrile comprising reacting a 4-methylphenylmagnesium reagent with a 2-halobenzonitrile in the presence of a catalyst system comprising a catalyst selected from nickel catalysts and palladium catalysts and a zinc cocatalyst. | ||||||
| 120 | Preparation and use of (3-alkoxy-phenyl) magnesium chlorides | US800879 | 1997-02-14 | US5852216A | 1998-12-22 | Michael Finkam; Thomas Kohnen; Werner Winter |
| A method of preparing (3-alkoxyphenyl)magnesium chlorides and the use thereof for reaction with certain carbonyl compounds are described. | ||||||
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