肾癌诊断、肾癌患者预后预测用的组合物及方法
阅读：625发布：2022-05-21
专利汇可以提供肾癌诊断、肾癌患者预后预测用的组合物及方法专利检索，专利查询，专利分析的服务。并且本 发明 涉及含有1个或多个多核苷酸、或者 抗体 或其 片段 的、用于肾癌的检测·诊断、肾癌的转移诊断及/或肾癌 预后 预测的组合物、 试剂 盒 或DNA芯片、及其应用，其中，所述多核苷酸选自与来自预后良好的患者的肾癌细胞相比，在来自预后恶化的患者的肾癌细胞中表达 水 平发生变化的多核苷酸、其变异体或其片段，所述抗体或其片段与所述表达水平变化的多肽、其变异体或其片段特异性结合。，下面是肾癌诊断、肾癌患者预后预测用的组合物及方法专利的具体信息内容。
1、一种用于体外检测、确定或预测受试者的肾癌的存在或转移 的组合物，所述组合物含有选自下述I组及/或II组中的1种或2种以上 探针，
I组：由下述(a)～(e)构成的多核苷酸：
(a)由序列号1～10、12～20、22～47表示的碱基序列构成的多 核苷酸、其变异体、或其含有15个以上连续碱基的片段；
(b)含有序列号1～10、12～20、22～47表示的碱基序列的多核 苷酸；
(c)由与序列号1～10、12～20、22～47表示的碱基序列互补的 碱基序列构成的多核苷酸、其变异体、或其含有15个以上连续碱基的 片段；
(d)含有与序列号1～10、12～20、22～47表示的碱基序列互补 的碱基序列的多核苷酸；及
(e)与所述(a)～(d)中任一个多核苷酸在严格条件下杂交的 多核苷酸、或其含有15个以上连续碱基的片段；
II组：由下述(f)～(h)构成的抗体、其片段或者其化学修饰衍 生物：
(f)与含有由序列号1～10、12～20、22～47表示的碱基序列编 码的氨基酸序列的多肽、或含有序列号101～110、112～120、122～ 147表示的氨基酸序列的多肽、它们的变异体、或者它们的片段中的 至少1个特异性结合的抗体、其片段或者其化学修饰衍生物；
(g)与含有序列号151、153、155～160表示的氨基酸序列的多 肽、它们的变异体、或者它们的片段中的至少1个特异性结合的抗体、 其片段或者其化学修饰衍生物；及
(h)与含有序列号161～190表示的氨基酸序列的多肽、它们的 变异体、或者它们的片段中的至少1个特异性结合的抗体、其片段或 者其化学修饰衍生物。
2、如权利要求1所述的组合物，其中，利用所述I组及II组(f)的 各探针能够检测、确定或预测肾癌的存在或转移。
3、如权利要求1所述的组合物，其中，利用所述II组(g)、(h) 的各探针对肾癌的存在进行检测、确定或预测。
4、如权利要求1所述的组合物，其中，所述多核苷酸为DNA或 RNA。
5、如权利要求1所述的组合物，其中，所述I组中的片段为含有60 个以上连续碱基的多核苷酸。
6、如权利要求1所述的组合物，其中，所述I组中的片段是在序列 号1～10、12～20、22～47中的任一个表示的碱基序列中分别含有序 列号51～60、62～70、72～97中的任一个表示的碱基序列的多核苷酸、 或含有与该多核苷酸的序列互补的碱基序列的多核苷酸。
7、如权利要求1所述的组合物，其中，所述I组中的片段是含有序 列号51～60、62～70、72～97中的任一个表示的碱基序列、或与其互 补的碱基序列的多核苷酸。
8、如权利要求1所述的组合物，所述组合物除含有所述I组的探针 之外，还包含选自下述多核苷酸中的1个或2个以上作为探针：由序列 号11、21、48～50表示的碱基序列构成的多核苷酸、由其互补序列构 成的多核苷酸、与所述多核苷酸在严格条件下杂交的多核苷酸、或所 述多核苷酸的含有15个以上连续碱基的片段。
9、如权利要求8所述的组合物，其中，所述片段为含有60个以上 连续碱基的多核苷酸。
10、如权利要求8所述的组合物，其中，所述片段为在序列号11、 21、48～50表示的碱基序列中含有序列号61、71、98～100表示的碱 基序列的多核苷酸、或含有与该多核苷酸的序列互补的碱基序列的多 核苷酸。
11、如权利要求8所述的组合物，其中，所述片段为含有序列号 61、71、98～100表示的碱基序列、或与其互补的碱基序列的多核苷 酸。
12、如权利要求1所述的组合物，所述组合物除含有所述II组(f) 的探针之外，还含有与序列号111、121、148～150表示的多肽、其变 异体或其片段中的至少1个特异性结合的抗体、其片段或其化学修饰 衍生物。
13、如权利要求1所述的组合物，所述组合物除含有所述II组(g) 的探针之外，还含有与含有序列号152、154、191表示的氨基酸序列 的多肽、其变异体或其片段中的至少1个特异性结合的抗体、其片段 或其化学修饰衍生物。
14、如权利要求1所述的组合物，所述组合物除含有所述II组(h) 的探针之外，还含有与含有序列号192～197表示的氨基酸序列的多 肽、其变异体或其片段中的至少1个特异性结合的抗体、其片段或其 化学修饰衍生物。
15、如权利要求1所述的组合物，其中，所述多肽或变异体的片 段含有由至少7个氨基酸构成的表位。
16、如权利要求1所述的组合物，其中，所述抗体为多克隆抗体、 单克隆抗体、合成抗体、重组抗体、多重特异性抗体或单链抗体。
17、如权利要求1所述的组合物，其中，组合含有选自所述I组或 II组(f)、(g)、(h)中的2种以上探针。
18、一种用于体外检测、确定或预测受试者的肾癌的存在或转移 的试剂盒，所述试剂盒含有选自权利要求1定义的I组或II组(f)、(g)、 (h)中的1种或2种以上探针。
19、如权利要求18所述的试剂盒，其中还含有由序列号11、21、 48～50表示的碱基序列构成的多核苷酸、由其互补序列构成的多核苷 酸、与所述多核苷酸在严格条件下杂交的多核苷酸、或所述多核苷酸 的含有15个以上连续碱基的片段作为探针。
20、如权利要求18所述的试剂盒，其中，所述探针为由序列号1～ 10、11、12～20、21、22～47、48～50中的任一个表示的碱基序列构 成的多核苷酸、由其互补序列构成的多核苷酸、与所述多核苷酸在严 格条件下杂交的多核苷酸、或所述多核苷酸的含有15个以上连续碱基 的片段。
21、如权利要求18所述的试剂盒，其中，所述I组的片段为含有60 个以上连续碱基的多核苷酸。
22、如权利要求18所述的试剂盒，其中，所述I组的片段是在序列 号1～10、11、12～20、21、22～47、48～50中的任一个表示的碱基 序列中，含有60个以上连续碱基的多核苷酸并且分别含有序列号51～ 60、61、62～70、71、72～97、98～100中的任一个表示的碱基序列 的多核苷酸、或含有与该多核苷酸序列互补的碱基序列的多核苷酸。
23、如权利要求1 8所述的试剂盒，其中，所述I组中的片段是含有 序列号51～60、61、62～70、71、72～97、98～100中的任一个表示 的碱基序列、或其互补碱基序列的多核苷酸。
24、如权利要求18所述的试剂盒，其中，所述I组中的片段是由序 列号51～60、61、62～70、71、72～97、98～100中的任一个表示的 碱基序列构成的多核苷酸。
25、如权利要求18所述的试剂盒，其中包含2个以上至全部的含 有序列号51～60、61、62～70、71、72～97、98～100表示的碱基序 列或其互补序列的多核苷酸。
26、如权利要求18所述的试剂盒，所述试剂盒除含有所述II组(f) 的探针之外，还含有与序列号111、121、148～150表示的多肽、其变 异体或其片段中的至少1个特异性结合的抗体、其片段或其化学修饰 衍生物。
27、如权利要求18所述的试剂盒，所述试剂盒除含有所述II组(g) 的探针之外，还含有与序列号152、154、191表示的多肽、其变异体 或其片段中的至少1个特异性结合的抗体、其片段或其化学修饰衍生 物。
28、如权利要求18所述的试剂盒，所述试剂盒除含有所述II组(h) 的探针之外，还含有与序列号192～197表示的多肽、其变异体或其片 段中的至少1个特异性结合的抗体、其片段或其化学修饰衍生物。
29、如权利要求18所述的试剂盒，其中，所述探针被单独或组合 包装在不同容器中。
30、一种用于体外检测、确定或预测受试者的肾癌的存在或转移 的DNA芯片，所述DNA芯片含有选自权利要求1定义的I组(a)～(e) 中的1种或2种以上探针。
31、如权利要求30所述的DNA芯片，其中还含有由序列号11、21、 48～50表示的碱基序列构成的多核苷酸、其变异体及/或其片段。
32、如权利要求30所述的DNA芯片，其中包含2个以上～全部的 含有序列号51～60、61、62～70、71、72～97、98～100表示的碱基 序列或其互补序列的多核苷酸。
33、一种体外检测、确定或预测肾癌的存在或转移的方法，所述 方法使用选自权利要求1定义的I组及/或II组(f)、(g)、(h)中 的探针，体外测定在来自受试者的生物试样中1种或多种肾癌相关靶 核酸的存在或存在量或表达量。
34、如权利要求33所述的方法，其中，使用DNA芯片进行所述测 定。
35、如权利要求33所述的方法，其中，以相对于对照试样的变化 为指标，进行所述肾癌的存在或转移的检测、确定或预测。
36、如权利要求33所述的方法，其中，所述测定通过免疫学方法 进行。
37、如权利要求36所述的方法，其中，所述采用免疫学方法的测 定使用所述II组(f)、(g)或(h)的抗体、其片段、或其化学修饰 衍生物进行。
38、如权利要求37所述的方法，其中，所述抗体、其片段、或其 化学修饰衍生物是被标记的。
39、如权利要求33所述的方法，其中，所述生物试样是来自肾的 组织或细胞、血液、血浆、血清、或者尿。
40、一种体外检测、确定或预测肾癌的存在或转移的方法，所述 方法包括使用权利要求1所述的组合物、权利要求18所述的试剂盒、 或权利要求30所述的DNA芯片，体外测定在来自受试者的生物试样中 1个或多个肾癌相关靶核酸的存在或存在量或表达量。
41、一种体外预测受试者的预后、及/或者肾癌是否转移的方法， 所述方法通过使用选自权利要求1定义的I组中的探针、或者含有该探 针的、权利要求1所述的组合物、权利要求18所述的试剂盒、或权利 要求30所述的DNA芯片，将来自受试者的肾癌细胞生物试样中靶核酸 的表达水平，与来自预后不良的肾癌患者群体的肾癌细胞中靶核酸的 表达水平及/或来自预后良好的患者群体的肾癌细胞中靶核酸的表 达水平相比较，体外预测受试者的预后、及/或者肾癌是否转移，其 中，该靶核酸可以通过该组合物、试剂盒或DNA芯片中含有的多核苷 酸、其变异体或其片段进行检测，并且，来自受试者的该靶核酸的表 达水平与预后良好的肾癌患者群体的表达水平及/或预后不良的患 者群体的表达水平相比发生变化时，分别确定受试者的预后恶化或受 试者的预后良好、及/或确定肾癌转移或肾癌没有转移。
42、如权利要求41所述的方法，其中，使用DNA芯片。
43、如权利要求41所述的方法，所述方法包括如下步骤：
第1步骤：使用选自权利要求1定义的I组中的探针、或者含有该探 针的、权利要求1所述的组合物、权利要求18所述的试剂盒、或权利 要求30所述的DNA芯片，体外测定多个生物试样中靶核酸的表达水 平，所述生物试样是已知的来自预后不良的患者的肾癌细胞及/或来 自预后良好的患者的肾癌细胞；
第2步骤：以所述第1步骤得到的该靶核酸的表达水平的测定值作 为训练样本，制作辨别式(支持向量机)；
第3步骤：与第1步骤相同地体外测定在来自受试者肾癌的生物试 样中该靶核酸的表达水平；
第4步骤：将第3步骤得到的该靶核酸的表达水平的测定值代入所 述第2步骤得到的辨别式中，以由该辨别式得到的结果为基础，预测 受试者的预后、及/或确定来自受试者的肾癌是来自发生转移的患者 的肾癌、或是来自没有发生转移的患者的肾癌；
其中，该靶核酸是可以通过该组合物、试剂盒或DNA芯片中含有 的多核苷酸、其变异体或其片段检测的靶核酸。
44、选自权利要求1定义的I组及/或II组中的探针、或者含有该 探针的、权利要求1所述的组合物、权利要求18所述的试剂盒、或权 利要求30所述的DNA芯片在体外检测、确定或预测在来自受试者的生 物试样中肾癌的存在或转移中的用途。
技术领域
本发明涉及对受试者预后预测有用的、及/或对肾癌转移预测或 检测有用的确定(诊断)用组合物；利用该组合物预测或确定受试者 预后的方法、及/或利用该组合物预测或检测肾癌转移的方法；及利 用该组合物预测受试者预后、及/或预测肾癌转移的试剂盒。
背景技术
肾脏是重要的泌尿器官，具有过滤血液生成尿，从而将生物体内 的废物排到体外的作用。另外，同时也是重要的内分泌器官，可产生 控制血压的血管紧张素、为红细胞造血因子的红细胞生成素等激素。
肾脏中发生的肿瘤有：发生在成人中的肾细胞癌和发生在儿童中 的Wilms′肿瘤、为稀少肿瘤的肉瘤，以下将发生率最高的恶性肿瘤即 肾细胞癌称为肾癌。在日本肾癌的发生率为每10万人中有约2.5人，男 女比例为2～3∶1，男性具有多发倾向。在泌尿系统恶性肿瘤中，是 继前列腺癌、膀胱癌之后发生率最高的肿瘤。
作为肾癌的危险因素，已知有遗传学因素，但一般可以举出吸烟、 过度摄取脂肪等。另外，已知长期接受透析的患者中该肿瘤的发生率 高。
肾癌患者在肿瘤最大直径为5cm以下时，几乎没有任何自觉症状， 多在检诊时通过CT扫描等被发现。尺寸大的肿瘤，可见血尿、腹部肿 瘤、疼痛等。另外，作为全身症状，有时引起发热、体重减少、贫血 等，偶尔由内分泌因子引起红细胞增多症或高血压、高钙血症等。另 一方面，有时因肾癌扩散至后腔静脉内，引起腹部体表的静脉曲张或 睾丸静脉瘤。大约20％的肾癌在肺或骨转移后被发现。肾癌在静脉中 具有较强的肿瘤扩散倾向，易向其它脏器转移。
作为肾癌的检查法，有超声波检查、CT检查、血管造影检查等方 法，由于特异性生化学标记物尚属未知，故必须利用机器进行检查。
另外，肾癌还可以按病理学分成几类，已知其中占90％的透明细 胞型肾癌的发生原因在于为癌抑制基因的VHL(von-Hippel- Lindau)基因的缺陷(非专利文献1)。VHL基因缺陷通过阻断HIF- α/VHF聚集，导致低氧诱导基因组转录活化(非专利文献2)，引起 VEGF、TGFβ等基因表达增强。
肾癌治疗主要采用外科疗法。无论病期如何，在能够切除时将肾 脏全部或部分切除为最常使用的方法，即使发生转移，也可考虑采用 外科方法将肾脏切除。作为外科疗法以外的方法，有肾动脉的动脉栓 塞术，该方法在不能进行肾脏切除时、或在切除较大肿瘤时于手术前 实施。
最近由于图像诊断技术的发展，肾癌即使尺寸非常小也能在早期 发现，初期癌的治疗中90％以上治愈。但是，5cm以上的较大肿瘤或 发生转移的肿瘤的治疗效果差(全部肾细胞癌患者的5年生存率为 50～60％)，因此，高效率地检查、诊断有无肿瘤或有无转移，且预 测预后，确定治疗方案是十分重要的。
专利文献1中公开了利用基因表达的差异检测或诊断人肾癌的方 法。另外，作为已知在人肾癌中增加的蛋白质，有通过分解细胞外基 质使癌细胞的运动性增加的MMP2(非专利文献3)、已知在肾功能 障碍中表达增加的TNFRSF7(非专利文献4)，除此之外，还有PDE8B (专利文献2)、FLOT1(专利文献3)、CD5(非专利文献5)、ECM1 (专利文献4)等，然而，相对而言其特异性并不高，仅通过其表达 量获得的高灵敏性的肾癌检查方法尚未用于临床。进而，推断 MCM3AP(专利文献5)、KRT19(专利文献6)、SLK4(专利文献7)、 C5P1(专利文献8)、FGF2(非专利文献6)、MMP14(非专利文献 7)、ERBB2(非专利文献8)等，可作为包括肾癌的癌症的肿瘤相关 标记物。
肾脏中发生的肿瘤有：发生在成人中的肾细胞癌和发生在儿童中 的Wilms′肿瘤、为稀少肿瘤的肉瘤，以下将发生率最高的恶性肿瘤即 肾细胞癌称为肾癌。在日本肾癌的发生率为每10万人中有约2.5人，男 女比例为2～3∶1，男性具有多发倾向。在泌尿系统恶性肿瘤中，是 继前列腺癌、膀胱癌之后发生率最高的肿瘤。
作为肾癌的危险因素，已知有遗传学因素，但一般可以举出吸烟、 过度摄取脂肪等。另外，已知长期接受透析的患者中该肿瘤的发生率 高。
肾癌患者在肿瘤最大直径为5cm以下时，几乎没有任何自觉症状， 多在检诊时通过CT扫描等被发现。尺寸大的肿瘤，可见血尿、腹部肿 瘤、疼痛等。另外，作为全身症状，有时引起发热、体重减少、贫血 等，偶尔由内分泌因子引起红细胞增多症或高血压、高钙血症等。另 一方面，有时因肾癌扩散至后腔静脉内，引起腹部体表的静脉曲张或 睾丸静脉瘤。大约20％的肾癌在肺或骨转移后被发现。肾癌在静脉中 具有较强的肿瘤扩散倾向，易向其它脏器转移。
作为肾癌的检查法，有超声波检查、CT检查、血管造影检查等方 法，由于特异性生化学标记物尚属未知，故必须利用机器进行检查。
另外，肾癌还可以按病理学分成几类，已知其中占90％的透明细 胞型肾癌的发生原因在于为癌抑制基因的VHL(von-Hippel- Lindau)基因的缺陷(非专利文献1)。VHL基因缺陷通过阻断HIF- α/VHF聚集，导致低氧诱导基因组转录活化(非专利文献2)，引起 VEGF、TGFβ等基因表达增强。
肾癌治疗主要采用外科疗法。无论病期如何，在能够切除时将肾 脏全部或部分切除为最常使用的方法，即使发生转移，也可考虑采用 外科方法将肾脏切除。作为外科疗法以外的方法，有肾动脉的动脉栓 塞术，该方法在不能进行肾脏切除时、或在切除较大肿瘤时于手术前 实施。
最近由于图像诊断技术的发展，肾癌即使尺寸非常小也能在早期 发现，初期癌的治疗中90％以上治愈。但是，5cm以上的较大肿瘤或 发生转移的肿瘤的治疗效果差(全部肾细胞癌患者的5年生存率为 50～60％)，因此，高效率地检查、诊断有无肿瘤或有无转移，且预 测预后，确定治疗方案是十分重要的。
专利文献1中公开了利用基因表达的差异检测或诊断人肾癌的方 法。另外，作为已知在人肾癌中增加的蛋白质，有通过分解细胞外基 质使癌细胞的运动性增加的MMP2(非专利文献3)、已知在肾功能 障碍中表达增加的TNFRSF7(非专利文献4)，除此之外，还有PDE8B (专利文献2)、FLOT1(专利文献3)、CD5(非专利文献5)、ECM1 (专利文献4)等，然而，相对而言其特异性并不高，仅通过其表达 量获得的高灵敏性的肾癌检查方法尚未用于临床。进而，推断 MCM3AP(专利文献5)、KRT19(专利文献6)、SLK4(专利文献7)、 C5P1(专利文献8)、FGF2(非专利文献6)、MMP14(非专利文献 7)、ERBB2(非专利文献8)等，可作为包括肾癌的癌症的肿瘤相关 标记物。
发明内容
如上所述，已知多种肾癌的表达基因标记物，但几乎不知能够预 测转移的诊断标记物及预测预后的标记物。由于已知的标记物缺乏特 异性及/或灵敏性、或尚未确立从生物试样中有效地检测的方法，所 以一般情况下不用于临床，人们迫切期望开发出特异性及灵敏性更高 的肾癌标记物。
推测如果能够发现多个有效的肾癌标记物，则肾癌的治疗及转移 性肾癌的治疗能够取得很大进步。特别是，转移性肾癌患者多为预后 不良，但通过在诊断时获知是否转移，可进行有效治疗，能够期待改 善预后。
本发明的目的在于提供一种对肾癌诊断、肾癌转移(或预后)的 诊断、及肾癌治疗有用的疾病确定用组合物、试剂盒或DNA芯片。
本发明的目的还在于提供使用上述组合物、试剂盒或DNA芯片来 检测、确定或者预测肾癌的存在或转移的方法。
作为标记物的寻找方法，可以举出下述方法，即，观察肾癌患者 的预后，通过某种方法对来自预后良好的肾癌患者的肾癌细胞和来自 预后不良的肾癌患者的肾癌细胞中的基因表达或蛋白质表达、或细胞 代谢产物等的量进行比较的方法，或对来自预后良好的患者的含有肾 癌细胞的组织的体液或来自预后不良的患者的含有肾癌细胞的组织 的体液中所含的基因、蛋白质、代谢产物等的量进行测定的方法。
近年，使用DNA阵列进行的基因表达量分析，被特别广泛地用作 寻找上述标记物的方法。DNA阵列中固定有使用与数百至数万种基因 对应的碱基序列的探针。通过将受试试样添加到DNA阵列中，使试样 中的基因与探针结合，利用某种方法测定结合量，由此可以知道受试 试样中的基因量。对应于固定在DNA阵列上的探针的基因可以自由选 择，另外，受试试样使用来自预后良好、及预后不良的患者的肾癌细 胞，通过比较试样中的表达基因量，能够推断可成为肾癌转移、及/ 或肾癌患者预后预测标记物的基因。
为了解决上述课题，本发明人等通过DNA阵列对来自预后良好的 肾癌患者的肾癌组织中及来自预后不良的肾癌患者的肾癌组织中的 基因表达进行分析。并且，以由DNA阵列测定的基因表达量对各患者 组手术后的经时生存率变化的影响为指标，选择能够判别来自预后良 好的肾癌患者的肾癌组织及来自预后不良的肾癌患者的肾癌组织、及 /或能够判别肾癌是否转移的基因，从而完成本发明。
本发明具有以下特征。
(1)一种用于体外检测、确定或预测受试者的肾癌的存在或转 移的组合物，其中含有选自下述I组及/或II组中的1个或2个以上探 针：
I组：由下述(a)～(e)构成的多核苷酸：
(a)由序列号1～10、12～20、22～47表示的碱基序列构成的多 核苷酸、其变异体、或其含有15个以上连续碱基的片段，
(b)含有序列号1～10、12～20、22～47表示的碱基序列的多核 苷酸，
(c)由与序列号1～10、12～20、22～47表示的碱基序列互补的 碱基序列构成的多核苷酸、其变异体、或其含有15个以上连续碱基的 片段，
(d)含有与序列号1～10、12～20、22～47表示的碱基序列互补 的碱基序列的多核苷酸，及
(e)与上述(a)～(d)中的任一个多核苷酸在严格条件下杂交 的多核苷酸、或其含有15个以上连续碱基的片段
II组：由下述(f)～(h)构成的抗体、其片段或者其化学修饰衍 生物：
(f)与含有由序列号1～10、12～20、22～47表示的碱基序列编 码的氨基酸序列的多肽、或含有序列号101～110、112～120、122～ 147表示的氨基酸序列的多肽、它们的变异体、或者它们的片段中的 至少1个特异性结合的抗体、其片段或者其化学修饰衍生物，
(g)与含有序列号151、153、155～160表示的氨基酸序列的多 肽、它们的变异体、或者它们的片段中的至少1个特异性结合的抗体、 其片段或者其化学修饰衍生物，及
(h)与含有序列号161～190表示的氨基酸序列的多肽、它们的 变异体、或者它们的片段中的至少1个特异性结合的抗体、其片段或 者其化学修饰衍生物。
(2)如(1)所述的组合物，其中，利用上述I组及II组(f)的各 探针能够检测、确定或预测肾癌的存在或转移。
(3)如(1)所述的组合物，其中，利用上述II组(g)、(h) 的各探针能够检测、确定或预测肾癌的存在。
(4)如(1)所述的组合物，其中，所述多核苷酸为DNA或RNA。
(5)如(1)所述的组合物，其中，所述I组中的片段为含有60 个以上连续碱基的多核苷酸。
(6)如(1)所述的组合物，其中，所述I组中的片段为在序列号 1～10、12～20、22～47中任一个表示的碱基序列中，分别含有序列 号51～60、62～70、72～97中任一个表示的碱基序列的多核苷酸、或 含有与该多核苷酸的序列互补的碱基序列的多核苷酸。
(7)如(1)所述的组合物，其中，所述I组中的片段是含有序列 号51～60、62～70、72～97中任一个表示的碱基序列、或与上述碱基 序列互补的碱基序列的多核苷酸。
(8)如(1)所述的组合物，所述组合物除含有上述I组的探针之 外，还含有选自由序列号11、21、48～50表示的碱基序列构成的多核 苷酸、由其互补序列构成的多核苷酸、与上述多核苷酸在严格条件下 杂交的多核苷酸、或上述多核苷酸的含有15个以上连续碱基的片段中 的1个或2个以上多核苷酸作为探针。
(9)如(8)所述的组合物，其中，所述片段为含有60个以上连 续碱基的多核苷酸。
(10)如(8)所述的组合物，其中，所述片段为在序列号11、 21、48～50表示的碱基序列中，含有序列号61、71、98～100表示的 碱基序列的多核苷酸、或含有与该多核苷酸的序列互补的碱基序列的 多核苷酸。
(11)如(8)所述的组合物，其中，所述片段是含有序列号61、 71、98～100表示的碱基序列、或与其互补的碱基序列的多核苷酸。
(12)如(1)所述的组合物，所述组合物除含有上述II组(f) 的探针之外，还含有与序列号111、121、148～150表示的多肽、其变 异体或其片段中的至少1个特异性结合的抗体、其片段或其化学修饰 衍生物。
(13)如(1)所述的组合物，所述组合物除含有上述II组(g) 的探针之外，还含有与具有序列号152、154、191表示的氨基酸序列 的多肽、其变异体或其片段中的至少1个特异性结合的抗体、其片段 或其化学修饰衍生物。
(14)如(1)所述的组合物，所述组合物除含有上述II组(h) 的探针之外，还含有与具有序列号192～197表示的氨基酸序列的多 肽、其变异体或其片段中的至少1个特异性结合的抗体、其片段或其 化学修饰衍生物。
(15)如(1)、(12)、(13)或(14)所述的组合物，其中， 所述多肽或变异体的片段含有由至少7个氨基酸构成的表位。
(16)如权利要求(1)、(12)、(13)或(14)所述的组合 物，其中，所述抗体为多克隆抗体、单克隆抗体、合成抗体、重组抗 体、多重特异性抗体或单链抗体。
(17)如(1)所述的组合物，其中组合含有选自上述I组或II组 (f)、(g)、(h)中的2个以上探针。
(18)一种用于体外检测、确定或预测受试者的肾癌的存在或转 移的试剂盒，所述试剂盒含有选自上述(1)中定义的I组或II组(f)、 (g)、(h)中的1个或2个以上探针。
(19)如(18)所述的试剂盒，其中还含有由序列号11、21、48～ 50表示的碱基序列构成的多核苷酸、由其互补序列构成的多核苷酸、 与上述多核苷酸在严格条件下杂交的多核苷酸、或上述多核苷酸的含 有15个以上连续碱基的片段作为探针。
(20)如(18)或(19)所述的试剂盒，其中，所述探针为由序 列号1～10、11、12～20、21、22～47、48～50中任一个表示的碱基 序列构成的多核苷酸、由其互补序列构成的多核苷酸、与上述多核苷 酸在严格条件下杂交的多核苷酸、或上述多核苷酸的含有15个以上连 续碱基的片段。
(21)如(18)～(20)中任一项所述的试剂盒，其中，所述I 组中的片段为含有60个以上连续碱基的多核苷酸。
(22)如(18)～(20)中任一项所述的试剂盒，其中，所述I 组中的片段为在序列号1～10、11、12～20、21、22～47、48～50中 任一个表示的碱基序列中含有60个以上连续碱基的多核苷酸，并且分 别含有序列号51～60、61、62～70、71、72～97、98～100中任一个 表示的碱基序列的多核苷酸、或含有与该多核苷酸的序列互补的碱基 序列的多核苷酸。
(23)如(18)～(20)中任一项所述的试剂盒，其中，所述I 组中的片段为含有序列号51～60、61、62～70、71、72～97、98～100 中任一个表示的碱基序列、或与其互补的碱基序列的多核苷酸。
(24)如(18)～(20)中任一项所述的试剂盒，其中，所述I 组中的片段为由序列号51～60、61、62～70、71、72～97、98～100 中任一个表示的碱基序列构成的多核苷酸。
(25)如(18)所述的试剂盒，其中含有2个以上至全部的具有 序列号51～60、61、62～70、71、72～97、98～100表示的碱基序列 或其互补序列的多核苷酸。
(26)如(18)所述的试剂盒，所述试剂盒除含有上述II组(f) 的探针之外，还含有与序列号111、121、148～150表示的多肽、其变 异体或其片段中的至少1个特异性结合的抗体、其片段或其化学修饰 衍生物。
(27)如(18)所述的试剂盒，所述试剂盒除含有上述II组(g) 的探针之外，还含有与序列号152、154、191表示的多肽、其变异体 或其片段中的至少1个特异性结合的抗体、其片段或其化学修饰衍生 物。
(28)如(18)所述的试剂盒，所述试剂盒除含有上述II组(h) 的探针之外，还含有与序列号192～197表示的多肽、其变异体或其片 段中的至少1个特异性结合的抗体、其片段或其化学修饰衍生物。
(29)如(18)所述的试剂盒，其中，所述探针单独或组合包装 在不同容器中。
(30)一种用于体外检测、确定或预测受试者的肾癌的存在或转 移的DNA芯片，所述DNA芯片含有选自上述(1)中定义的I组(a)～ (e)中的1个或2个以上探针。
(31)如(30)所述的DNA芯片，其中还含有由序列号11、21、 48～50表示的碱基序列构成的多核苷酸、其变异体及/或其片段。
(32)如(30)所述的DNA芯片，其中含有2个以上～全部的具 有序列号51～60、61、62～70、71、72～97、98～100表示的碱基序 列或其互补序列的多核苷酸。
(33)一种体外检测、确定或预测肾癌的存在或转移的方法，其 中使用选自上述1中定义的I组及/或II组(f)、(g)、(h)中的探 针，体外测定在来自受试者的生物试样中1种或多种肾癌相关靶核酸 的存在或存在量或表达量。
(34)如(33)所述的方法，其中，使用DNA芯片进行所述测定。
(35)如(33)所述的方法，其中，以与对照试样相比的变化为 指标，检测、确定或预测所述肾癌的存在或转移。
(36)如(33)所述的方法，其中，所述测定通过免疫学方法进 行。
(37)如(36)所述的方法，其中，所述采用免疫学方法的测定 使用所述II组(f)、(g)或(h)的抗体、其片段、或其化学修饰衍 生物进行。
(38)如(37)所述的方法，其中，所述抗体、其片段、或其化 学修饰衍生物被标记。
(39)如(33)所述的方法，其中，所述生物试样是来自肾的组 织或细胞、血液、血浆、血清、或者尿。
(40)一种体外检测、确定或预测肾癌的存在或转移的方法，所 述方法包括使用上述(1)所述的组合物、上述(18)所述的试剂盒、 或上述(30)所述的DNA芯片，体外测定在来自受试者的生物试样中 的1个或多个肾癌相关靶核酸的存在或存在量或表达量。
(41)一种方法，所述方法使用选自上述(1)中定义的I组中的 探针、或者、含有该探针的、上述(1)所述的组合物、上述(18) 所述的试剂盒、或上述(30)所述的DNA芯片，通过将来自受试者的 肾癌细胞生物试样中靶核酸的表达水平，与来自预后不良的肾癌患者 群体的肾癌细胞中靶核酸的表达水平及/或来自预后良好的患者群 体的肾癌细胞中靶核酸的表达水平相比较，体外预测受试者的预后、 及/或肾癌是否转移，其中，该靶核酸可以通过该组合物、试剂盒或 DNA芯片中含有的多核苷酸、其变异体或其片段进行检测，并且，来 自受试者的该靶核酸的表达水平与预后良好的肾癌患者群体的表达 水平及/或预后不良的患者群体的表达水平相比发生变化时，分别确 定受试者的预后恶化或受试者的预后良好、及/或确定肾癌发生转移 或肾癌没有发生转移。
(42)如(41)所述的方法，其中，使用DNA芯片。
(43)如(41)或(42)所述的方法，所述方法包含如下步骤：
第1步骤：使用选自上述(1)中定义的I组中的探针、或者、含有 该探针的、上述(1)所述的组合物、上述(18)所述的试剂盒、或 上述(30)所述的DNA芯片，体外测定多个生物试样中靶核酸的表达 水平，所述生物试样是已知的来自预后不良的患者的肾癌细胞及/或 来自预后良好的患者的肾癌细胞；
第2步骤：以所述第1步骤得到的该靶核酸的表达水平的测定值作 为训练样本制作辨别式(支持向量机support vector machine)；
第3步骤：与第1步骤相同地体外测定在来自受试者肾癌的生物试 样中该靶核酸的表达水平；
第4步骤：将第3步骤得到的该靶核酸的表达水平的测定值代入所 述第2步骤得到的辨别式中，以由该辨别式得到的结果为基础，预测 受试者的预后、及/或确定来自受试者的肾癌是来自有转移的患者的 肾癌、或是来自无转移的患者的肾癌；
此处，该靶核酸是可通过该组合物、试剂盒或DNA芯片中含有的 多核苷酸、其变异体或其片段进行检测的靶核酸。
(44)选自上述(1)中定义的I组及/或II组中的探针、或者、 含有该探针的、上述(1)所述的组合物、上述(18)所述的试剂盒、 或上述(30)所述的DNA芯片在体外检测、确定或预测来自受试者的 生物试样中肾癌的存在或转移中的用途。
定义
本说明书中使用的用语具有以下定义。
本说明书中所谓“探针”，是指核酸、抗体或二者的相当物，用 于检测、确定或者预测肾癌的存在或转移，能够与为肾癌相关标记物 的特定的基因类或由该基因类编码的多肽类结合。
核苷酸、多核苷酸、氨基酸、肽、多肽、蛋白质等用简写符号所 表达的含义是本技术领域中惯用的意思及含义。
本说明书中，所谓“多核苷酸”是指包括RNA及DNA两者的核酸。 需要说明的是，上述DNA包括cDNA、基因组DNA、及合成DNA中的 任一种。另外，上述RNA包括总RNA、mRNA、rRNA、及合成RNA 中的任一种。另外，本说明书中，多核苷酸可以与核酸互换使用。
本说明书中，所谓“cDNA”包括与由基因表达生成的RNA互补 的序列的全长DNA链、及由其部分序列构成的DNA片段。cDNA可以 以RNA为模板，通过使用聚T引物的RT-PCR(逆转录酶-聚合酶链 反应)进行合成。
本说明书中，所谓“基因”，不仅包括双链DNA，还包括构成双 链DNA的正链(或有义链)或互补链(或反义链)等单链DNA。另外， 对其长度没有特殊的限定。所以，本说明书中只要没有特殊说明，“基 因”是指包括人基因组DNA在内的双链DNA、包括cDNA在内的单链 DNA(正链)、具有与该正链互补的序列的单链DNA(互补链)、及 它们的片段中的任一种。另外该“基因”不仅包括特定碱基序列(或 序列号)表示的“基因”，还包括编码与上述基因编码的蛋白质的生 物学功能相同的蛋白质、例如同源物(homolog)、剪接变体等变异 体、及衍生物的“基因”。作为编码所述同源物、变异体或衍生物 的“基因”，具体而言可以举出具有在下述的严格条件下与上述序列 号1～50表示的任一个特定碱基序列的互补序列杂交的碱基序列的“基 因”。
例如，作为来自人的蛋白质的同源物(homolog)或其编码基因， 可以举出与该蛋白质或其编码人基因对应的其它生物种的蛋白质或 基因，上述蛋白质或基因同源物能够通过HomoloGene(http:// www.ncbi.nlm.nih.gov/homoloGene/)鉴定。具体而言，可 以将特定的人类氨基酸或碱基序列代入BLAST程序(Karlin，S.等、 Proceedings of the National Academic Sciences U.S.A.、1993年、第90 卷、p.5873-5877、http://www.ncbi.nlm.nih.gov/BLAST/)，得 到一致(得分最高、E值为0且同一性显示为100％)序列的登录号 (accession number)。作为BLAST程序，已知BLASTN(基因)、 BLASTX(蛋白质)等。例如，基因检索时，将由上述BLAST检索得 到的登录号输入UniGene(http://www.ncbi.nlm.nih.gov/UniGene/)， 将得到的UniGeneClusterID(以Hs.表示的序号)输入HomoloGene。 从作为结果得到的表示其它生物种基因与人类基因的基因同源物的 相关性的列表中选择其它生物种的基因作为与由特定碱基序列表示 的人类基因对应的基因同源物。另外在此方法中，也可以使用FASTA 程序(http://www.ddbj.nig.ac.jp/search/fasta-e.html)代替BLAST 程序。
需要说明的是，对“基因”的功能区域没有限定，例如可以含有表 达控制区域、编码区域、外显子或内含子。
本说明书中，所谓“转录产物”，是指以基因的DNA序列为模板 合成的信使RNA(mRNA)。RNA聚合酶与位于基因上游的称为启动 子的部位结合，使核糖核苷酸与3’末端结合，使其与DNA的碱基序列 互补，合成信使RNA。此信使RNA不仅含有基因本身，还含有包括表 达控制区域、编码区域、外显子或内含子在内的从转录起点至聚A序 列末端的全长序列。
本说明书中，所谓“翻译产物”，表示无论转录合成的信使RNA 接受/不接受剪接等修饰，都基于其信息而合成的蛋白质。在信使RNA 的翻译过程中，首先，核糖体与信使RNA结合，然后，根据信使RNA 的碱基序列结合氨基酸，从而合成蛋白质。
本说明书中，所谓“引物”包括能特异性识别、扩增基因表达产 生的RNA或来自该RNA的多核苷酸的连续的多核苷酸及/或与其互补 的多核苷酸。
此处，所谓互补的多核苷酸(互补链、反链)是指基于A：T(U)、 G：C的碱基配对，与由序列号定义的碱基序列构成的多核苷酸的全 长序列、或其部分序列(此处，为了便于说明，将上述序列称为正链) 具有碱基互补关系的多核苷酸。其中，所述互补链不只限于形成与作 为对象的正链的碱基序列完全互补的序列，也可以是具有能与作为对 象的正链在严格条件下杂交的互补关系的序列。
本说明书中，所谓“严格条件”，是指相对于探针对其它序列的 杂交，探针以可检测性更大的程度(例如，比背景至少大2倍)与其 靶序列杂交的条件。严格条件具有序列依赖性，因进行杂交的环境的 不同而不同。通过控制杂交及/或清洗条件为严格条件，可以鉴定与探 针100％互补的靶序列。
在本说明书中，“变异体”为核酸时，是指起因于多态性、突变、 转录时的选择剪接等的天然变异体、同源物、或以遗传密码的简并性 为基础的变异体、或在序列号1～50表示的碱基序列或其部分序列中缺 失、置换、添加或插入1个以上、优选1个或几个碱基的变异体、或者 与该碱基序列或其部分序列具有约80％以上、约85％以上、优选约90 ％以上、更优选约95％以上、约97％以上、约98％以上、或约99％以 上的同源性百分比的变异体、或者在上述定义的严格条件下与含有该 碱基序列或其部分序列的多核苷酸或寡核苷酸杂交的核酸，另一方 面，变异体为蛋白质或肽时，是指序列号101～197表示的氨基酸序列 或其部分序列中缺失、置换、添加或插入1个以上、优选1个或几个氨 基酸的变异体、或者与该氨基酸序列或其部分序列具有约80％以上、 约85％以上、优选约90％以上、较优选约95％以上、约97％以上、约 98％以上、或约99％以上的同源性百分比的变异体。
本说明书中，所谓“数个”是指约10、9、8、7、6、5、4、3或2 个以下的整数。
本说明书中，“同源性百分比”可以通过使用采用上述BLAST或 FASTA的蛋白质或基因检索系统，导入空位(gap)而进行确定(Karlin， S.等，1993年、Proceedings of the National Academic Sciences U.S.A.， 第90卷，P.5873-5877；Altschu1，S.F.等，1990年，Journal of Molecular Biology，第215卷，p.403-410；Pearson，W.R.等，1988年，Proceedings ofthe National Academic Sciences U.S.A.，第85卷，p.2444-2448)。
本说明书中，所谓“衍生物”为核酸时，是指通过荧光团等进行标 记的衍生物、含有修饰核苷酸(例如，含有卤素、甲基等烷基、甲氧 基等烷氧基、硫代、羧甲基等基团的核苷酸，及进行了碱基的再构建、 双键的饱和、脱氨基化、硫分子对氧分子的取代等的核苷酸等)的衍 生物等，另一方面，“衍生物”为蛋白质(包括抗体)时，是指通过酶、 荧光团、放射性同位素等标记产生的标记化衍生物、或乙酰化、酰化、 烷基化、磷酸化、硫酸化、糖基化衍生物等化学修饰衍生物。
本说明书中，所谓“诊断(或检测或确定)用组合物”或“疾病 确定用组合物”，是指为了预测肾癌患者的预后、及/或诊断是否罹 患肾癌、罹患程度、肾癌有无转移、或有无改善或改善程度，或为了 筛选对肾癌的预防、改善或治疗有用的候选物质，而直接或间接使用 的组合物。其中，包括能特异性识别或结合下述基因的核酸、寡核苷 酸及多核苷酸，所述基因与肾癌的罹患相关、在生物体内特别是在肾 组织内的表达发生变化，还包括能检测作为该基因翻译产物的蛋白质 的抗体等。上述核苷酸、寡核苷酸及多核苷酸，基于上述性质，能够 有效地用作用于检测在生物体内、组织或细胞内等表达的上述基因的 探针，或用于扩增在生物体内表达的上述基因的引物。本说明书中使 用的“组合物”，是指含有与本发明相关的单独探针、或2个以上不 同探针的混合物的组合物，该组合物可以为包括固体(例如冻干物 等)、溶液(例如水溶液、缓冲溶液等)的任意形态。另外，必要时， 在不对分析产生影响的条件下，该组合物还可以含有稳定剂、防腐剂 等添加剂。
本说明书中，作为检测、诊断对象的“生物试样”是指由生物体 采集的试样(或标本)，在所述试样中，随肾癌的发展，本发明的靶 基因表达发生变化、或者本发明靶多肽的量与正常对照相比发生变 化。生物试样包括例如肾组织、来自其周围的淋巴结或怀疑发生转移 的其他脏器等的组织、来自上述组织的细胞、及血液等体液等。
在本说明书中，“特异性结合”是指抗体或其片段只与本发明的靶 多肽、其变异体或其片段形成抗原-抗体复合体，而与其它肽性或多 肽性物质实质上不形成复合体。此处，“实质上”是指虽然程度小，但 能引起非特异性复合体的形成。
在本说明书中，“表位”是指在本发明的靶多肽、其变异体或其片 段中，具有抗原性或免疫原性的部分氨基酸区域(抗原决定簇)。表 位通常由至少5个氨基酸、优选至少7个氨基酸、更优选至少10个氨基 酸构成。
本说明书中，所谓“预后”，表示由采用Kaplan-Meier法(例如 BMJ(1998)317：1572)绘制的生存曲线表示的生存概率。另外， 所谓“预后良好”的患者组，是指根据某些临床信息将肾癌患者分类， 分别采用Kaplan-Meier法绘制生存曲线后，通过某些统计方法检定其 差异，具有差异显著(p＜0.05)的高生存率的组。相同地所谓“预后 不良”的患者组，是指根据某些临床信息将肾癌患者分类，分别采用 Kaplan-Meier法绘制生存曲线后，通过某些统计方法检定其差异，具 有差异显著(p＜0.05)的低生存率的组。癌是否转移是对患者预后产 生影响的要素之一，因此，预后预测与癌转移的预测部分相关。
本说明书中使用的“PABPN1基因”或“PABPN1”的术语，在没 有被序列号定义的情况下，包括编码由特定碱基序列(序列号1)表 示的Poly(A)-Binding Protein，Nuclear 1基因(DNA)、其同源物、 变异体及衍生物等的基因(DNA)。具体而言，包括序列号1所述的 PABPN1基因(Ensembl Gene ID，ENSG00000100836)或其他生物种 同源物等。PABPN1基因可以通过例如Brais，B.等，1998年、Nature genetics、第18卷、p.164-167中记载的方法获得。PABPN1基因的表 达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“PINK1基因”或“PINK1”的术语，在没有 被序列号定义的情况下，包括编码特定碱基序列(序列号2)表示的 PTEN Induced Putative Kinase 1基因(DNA)、其同源物、变异体及 衍生物等的基因(DNA)。具体而言，包括序列号2所述的PINK1基 因(Ensembl Gene ID，ENSG00000180056)或其他生物种同源物等。 PINK1基因可以通过例如Unoki，M.等，2001年、Oncogene、第20卷、 p.4457-4465中记载的方法获得。PINK1基因的表达变化可以成为肾 癌转移的指标尚属未知。
本说明书中使用的“TFF2基因”或“TFF2”的术语，在没有被序 列号定义的情况下，包括编码特定碱基序列(序列号3)表示的Trefoil Factor 2基因(DNA)、其同源物、变异体及衍生物等的基因(DNA)。 具体而言，包括序列号3所述的TFF2基因(Ensembl Gene ID，ENSG 00000160181)或其他生物种同源物等。TFF2基因可以通过例如 Tomasetto，C.等，1990年、EMBO Journal、第9卷、p.407-414中记 载的方法获得。TFF2基因的表达变化可以成为肾癌转移的指标尚属未 知。
本说明书中使用的“EIF3S9基因”或“EIF3S9”的术语，在没有 被序列号定义的情况下，包括编码特定碱基序列(序列号4)表示的 Eukaryotic Translation Initiation Factor 3 Subunit 9基因(DNA)、其同 源物、变异体及衍生物等的基因(DNA)。具体而言，包括序列号4 所述的EIF3S9基因(Ensembl Gene ID，ENSG00000106263)或其他 生物种同源物等。EIF3S9基因可以通过例如Methot，N.等，1997年、 Journal of Biological Chemistry、第272卷、p.1110-1116中记载的方法 获得。EIF3S9基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“MAX基因”或“MAX”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号5)表示的MAX Protein基因(DNA)、其同源物、变异体及衍生物等的基因(DNA)。 具体而言，包括序列号5所述的MAX基因(Ensembl Gene ID，ENSG 00000125952)或其他生物种同源物等。MAX基因可以通过例如 Wagner，A.等，1992年、Proceedings of the National Academic Sciences U.S.A.、第89卷、p.3111-3115中记载的方法获得。MAX基因的表达 变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“MLL4基因”或“MLL4”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号6)表示的 Trithorax Homolog 2基因(DNA)、其同源物、变异体及衍生物等的 基因(DNA)。具体而言，包括序列号6所述的MLL4基因(Ensembl Gene ID，ENSG 00000105663)或其他生物种同源物等。MLL4基因可以通 过例如Nagase，T.等，1997年、DNA Research、第4卷、p.141-150 中记载的方法获得。MLL4基因的表达变化可以成为肾癌转移的指标 尚属未知。
本说明书中使用的“CACNB2基因”或“CACNB2”的术语，在 没有被序列号定义的情况下，包括编码特定碱基序列(序列号7)表 示的Dihydropyridine-Sensitive L-Type，Calcium Channel Beta-2 Subunit基因(DNA)、其同源物、变异体及衍生物等的基因(DNA)。 具体而言，包括序列号7所述的CACNB2基因(Ensembl Gene ID，ENSG 00000165995)或其他生物种同源物等。CACNB2基因可以通过例如 Rosenfeld，M.等，1993年、Annals of Neurology.、第33卷、p.113-120 中记载的方法获得。CACNB2基因的表达变化可以成为肾癌转移的指 标尚属未知。
本说明书中使用的“ZMYND11基因”或“ZMYND11”的术语， 在没有被序列号定义的情况下，包括编码特定碱基序列(序列号8) 表示的Adenovirus 5 E1A-Binding Protein基因(DNA)、其同源物、 变异体及衍生物等的基因(DNA)。具体而言，包括序列号8所述的 ZMYND11基因(Ensembl Gene ID，ENSG00000015171)或其他生物 种同源物等。ZMYND 11基因可以通过例如Hateboer，G.等，1995年、 EMBO Journal、第14卷、p.3159-3169中记载的方法获得。ZMYND11 基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“BAT2基因”或“BAT2”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号9)表示的 Adenovirus 5 E1A-Binding Protein基因(DNA)、其同源物、变异体 及衍生物等的基因(DNA)。具体而言，包括序列号9所述的BAT2 基因(Ensembl Gene ID，ENSG00000111960)或其他生物种同源物等。 BAT2基因可以通过例如Banerji，J.等，1990年、Proceedings of the National Academic Sciences U.S.A.、第87卷、p.2374-2378中记载的 方法获得。BAT2基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“NRBP基因”或“NRBP”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号10)表示的 Nuclear Receptor Binding Protein基因(DNA)、其同源物、变异体及 衍生物等的基因(DNA)。具体而言，包括序列号10所述的NRBP基 因(Ensembl Gene ID，ENSG00000115216)或其他生物种同源物等。 NRBP基因可以通过例如Hooper，J.D..等，2000年、Genomics、第66 卷、p.113-118中记载的方法获得。NRBP基因的表达变化可以成为 肾癌转移的指标尚属未知。
本说明书中使用的“MCM3AP基因”或“MCM3AP”的术语，在 没有被序列号定义的情况下，包括编码特定碱基序列(序列号11)表 示的80KDa MCM3-Associated Protein基因(DNA)、其同源物、变 异体及衍生物等的基因(DNA)。具体而言，包括序列号11所述的 MCM3AP基因(Ensembl Gene ID，ENSG00000160294)或其他生物 种同源物等。MCM3AP基因可以通过例如Takei，Y.等，1998年、Journal of Biological Chemistry、第273卷、p.22177-22180中记载的方法获得。 虽在特表2005-520536中推定MCM3AP基因的表达变化可成为肾癌 的指标，但没有被证实。
本说明书中使用的“COL4A1基因”或“COL4A1”的术语，在没 有被序列号定义的情况下，包括编码特定碱基序列(序列号12)表示 的Collagen Alpha 1(IV)Chain基因(DNA)、其同源物、变异体及 衍生物等的基因(DNA)。具体而言，包括序列号12所述的COL4A1 基因(Ensembl Gene ID，ENSG00000139825)或其他生物种同源物等。 COL4A1基因可以通过例如Solomon，E.等，1985年Proceedings of the National Academic Sciences U.S.A.、第82卷、p.3330-3334中记载的 方法获得。COL4A1基因的表达变化可以成为肾癌转移的指标尚属未 知。
本说明书中使用的“MKNK1基因”或“MKNK1”的术语，在没 有被序列号定义的情况下，包括编码特定碱基序列(序列号13)表示 的MAP Kinase-Interacting Serine/Threonine Kinase 1基因(DNA)、 其同源物、变异体及衍生物等的基因(DNA)。具体而言，包括序列 号13所述的MKNK1基因(Ensembl Gene ID，.ENSG00000079277)或 其他生物种同源物等。MKNK1基因可以通过例如Fukunaga，R.等， 1997年、EMBO Journal、第16卷、P.1921-1933中记载的方法获得。 MKNK1基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“BBC3基因”或“BBC3”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号14)表示的 BCL2 Binding Component 3基因(DNA)、其同源物、变异体及衍生 物等的基因(DNA)。具体而言，包括序列号14所述的BBC3基因 (Ensembl Gene ID，ENSG00000105327)或其他生物种同源物等。 BBC3基因可以通过例如Yu，J.等，2001年、Molecular Cell、第7卷、 p.673-682中记载的方法获得。BBC3基因的表达变化可以成为肾癌转 移的指标尚属未知。
本说明书中使用的“FLJ10359基因”或“FLJ10359”的术语，在 没有被序列号定义的情况下，包括编码特定碱基序列(序列号15)表 示的Protein BAP28基因(DNA)、其同源物、变异体及衍生物等的基 因(DNA)。具体而言，包括序列号15所述的FLJ10359基因(Ensembl Gene ID，ENSG00000119285)或其他生物种同源物等。
本说明书中使用的“DPT基因”或“DPT”的术语，在没有被序 列号定义的情况下，包括编码碱基序列(序列号16)表示的 Dermatopontin基因(DNA)、其同源物、变异体及衍生物等的基因 (DNA)。具体而言，包括序列号16所述的DPT基因(Ensembl Gene ID，ENSG 00000143196)或其他生物种同源物等。DPT基因可以通过 例如Superti-Fruga，A.等，1993年、Genomics、第17卷、p.463-467 中记载的方法获得。DPT基因的表达变化可以成为肾癌转移的指标尚 属未知。
本说明书中使用的“C10orf76基因”或“C10orf76”的术语，在 没有被序列号定义的情况下，包括编码特定碱基序列(序列号17)表 示的基因(DNA)、其同源物、变异体及衍生物等的基因(DNA)。 具体而言，包括序列号17所述的C10orf76基因(Ensembl Gene ID， ENSG00000120029)或其他生物种同源物等。
本说明书中使用的“DIA1基因”或“DIA1”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号18)表示的 NADH-Cytochrome B5 Reductase基因(DNA)、其同源物、变异体 及衍生物等的基因(DNA)。具体而言，包括序列号18所述的DIA1 基因(Ensembl Gene ID，ENSG00000100243)或其他生物种同源物等。 DIA1基因可以通过例如Du，M.等，1997年、Biochemical Biophysical Research Communication、第235卷、p.779-783中记载的方法获得。 DIA1基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“PBK基因”或“PBK”的术语，在没有被序 列号定义的情况下，包括编码特定碱基序列(序列号19)表示的T- LAK Cell-Originated Protein Kinase基因(DNA)、其同源物、变异 体及衍生物等的基因(DNA)。具体而言，包括序列号19所述的PBK 基因(Ensembl Gene ID，ENSG00000168078)或其他生物种同源物等。 PBK基因可以通过例如Gaudet，S.等，2000年、Proceedings of the National Academic Sciences U.S.A.、第97卷、p.5167-5172中记载的 方法获得。PBK基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“PRKD2基因”或“PRKD2”的术语，在没有 被序列号定义的情况下，包括编码特定碱基序列(序列号20)表示的 Protein Kinase C，D2 Type基因(DNA)、其同源物、变异体及衍生 物等的基因(DNA)。具体而言，包括序列号20所述的PRKD2基因 (Ensembl Gene ID，ENSG00000105287)或其他生物种同源物等。 PRKD2基因可以通过例如Sturany，S.等，2001年、Journal of Biological Chemistry、第276卷、p.3310-3318中记载的方法获得。PRKD2基因 的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“KRT19基因”或“KRT19”的术语，在没有 被序列号定义的情况下，包括编码特定碱基序列(序列号21)表示的 Keratin，Type I Cytoskeletal 19基因(DNA)、其同源物、变异体及 衍生物等的基因(DNA)。具体而言，包括序列号21所述的KRT19 基因(Ensembl Gene ID，ENSG00000171345)或其他生物种同源物等。 KRT19基因可以通过例如Bader，B.等，1986年、EMBO Journal、第5 卷、p.1865-1875中记载的方法获得。虽然特表2005-507997中推定 KRT19基因的表达变化可成为肾癌的指标，但未被证实。
本说明书中使用的“FLJ23436基因”或“FLJ23436”的术语，在 没有被序列号定义的情况下，包括编码特定碱基序列(序列号22)表 示的基因(DNA)、其同源物、变异体及衍生物等的基因(DNA)。 具体而言，包括序列号22所述的FLJ23436基因(Ensembl Gene ID， ENSG00000169957)或其他生物种同源物等。FLJ23436基因可以通过 例如Beausoleil，S.A.等，2004年、Proceedings of the National Academic Sciences U.S.A.、第101卷、p.12130-12135中记载的方法获得。 FLJ23436基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“NPHS2基因”或“NPHS2”的术语，在没有 被序列号定义的情况下，包括编码特定碱基序列(序列号23)表示的 Podocin基因(DNA)、其同源物、变异体及衍生物等的基因(DNA)。 具体而言，包括序列号23所述的NPHS2基因(Ensembl Gene ID， ENSG00000116218)或其他生物种同源物等。NPHS2基因可以通过例 如Kestila，M.等，1998年、Molecular Cell、第1卷、p.575-582中记 载的方法获得。NPHS2基因的表达变化可以成为肾癌转移的指标尚属 未知。
本说明书中使用的“C3orf14基因”或“C3orf14”的术语，在没 有被序列号定义的情况下，包括编码特定碱基序列(序列号24)表示 的HT021基因(DNA)、其同源物、变异体及衍生物等的基因(DNA)。 具体而言，包括序列号24所述的C3orf14基因(Ensembl Gene ID， ENSG00000114405)或其他生物种同源物等。
本说明书中使用的“AGTR2基因”或“AGTR2”的术语，在没有 被序列号定义的情况下，包括编码特定碱基序列(序列号25)表示的 Type-2 Angiotensin II Receptor基因(DNA)、其同源物、变异体及 衍生物等的基因(DNA)。具体而言，包括序列号25所述的AGTR2 基因(Ensembl Gene ID，ENSG00000180772)或其他生物种同源物等。 AGTR2基因可以通过例如Koike，G.等，1994年、Biochemical Biophysical Research Communication、第203卷、p.1842-1850中记载 的方法获得。AGTR2基因的表达变化可以成为肾癌转移的指标尚属未 知。
本说明书中使用的“HTR1F基因”或“HTR1F”的术语，在没有 被序列号定义的情况下，包括编码特定碱基序列(序列号26)表示的 5-Hydroxytryptamine 1F Receptor基因(DNA)、其同源物、变异体 及衍生物等的基因(DNA)。具体而言，包括序列号26所述的HTR1F 基因(Ensembl Gene ID，ENSG00000179097)或其他生物种同源物等。 HTR1F基因可以通过例如Lovenberg，T.W.等，1993年、Proceedings of the National Academic Sciences U.S.A.、第90卷、p.2184-2188中记载 的方法获得。HTR1F基因的表达变化可以成为肾癌转移的指标尚属未 知。
本说明书中使用的“KIF3B基因”或“KIF3B”的术语，在没有 被序列号定义的情况下，包括编码特定碱基序列(序列号27)表示的 Kinesin-Like Protein KIF3B基因(DNA)、其同源物、变异体及衍 生物等的基因(DNA)。具体而言，包括序列号27所述的KIF3B基因 (Ensembl Gene ID，ENSG00000101350)或其他生物种同源物等。 KIF3B基因可以通过例如Nagase，T.等，1997年、DNA Research、第4 卷、p.141-150中记载的方法获得。KIF3B基因的表达变化可以成为 肾癌转移的指标尚属未知。
本说明书中使用的“DCN基因”或“DCN”的术语，在没有被序 列号定义的情况下，包括编码特定碱基序列(序列号28)表示的Decorin 基因(DNA)、其同源物、变异体及衍生物等的基因(DNA)。具体 而言，包括序列号28所述的DCN基因(Ensembl Gene ID，ENSG 00000011465)或其他生物种同源物等。DCN基因可以通过例如 Danielson，K.G.等，1993年、Genomics、第15卷、p.146-160中记载 的方法获得。DCN基因的表达变化可以成为肾癌转移的指标尚属未 知。
本说明书中使用的“STK22C基因”或“STK22C”的术语，在没 有被序列号定义的情况下，包括编码特定碱基序列(序列号29)表示 的Testis-Specific Serine/Threonine Kinase 22C基因(DNA)、其同 源物、变异体及衍生物等的基因(DNA)。具体而言，包括序列号29 所述的STK22C基因(Ensembl Gene ID，ENSG00000162526)或其他 生物种同源物等。STK22C基因可以通过例如Visconti，P.E.等，2001 年、Genomics、第77卷、p.163-170中记载的方法获得。STK22C基 因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“DKFZp566C0424基因”或“DKFZp566C0424” 的术语，在没有被序列号定义的情况下，包括编码特定碱基序列(序 列号30)表示的Putative MAPK Activating Protein PM20基因(DNA)、 其同源物、变异体及衍生物等的基因(DNA)。具体而言，包括序列 号30所述的DKFZp566C0424基因(ENSG00000055070)或其他生物 种同源物等。DKFZp566C0424基因可以通过例如Visconti，P.E.等， 2001年、Genomics、第77卷、p.163-170中记载的方法获得。 DKFZp566C0424基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“CNR1基因”或“CNR1”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号31)表示的 Cannabinoid Receptor 1基因(DNA)、其同源物、变异体及衍生物等 的Cannabinoid Receptor 1基因(DNA)。具体而言，包括序列号31所 述的CNR1基因(Ensembl Gene ID，ENSG00000118432)或其他生物 种同源物等。CNR1基因可以通过例如Matsuda，L.A.等，1990年、Nature、 第346卷、p.561-564中记载的方法获得。CNR1基因的表达变化可以 成为肾癌转移的指标尚属未知。
本说明书中使用的“HOMER3基因”或“HOMER3”的术语，在 没有被序列号定义的情况下，包括编码特定碱基序列(序列号32)表 示的HOMER，Neuronal Immediate Early Gene，3基因(DNA)、其同 源物、变异体及衍生物等的基因(DNA)。具体而言，包括序列号32 所述的HOMER3基因(Ensembl Gene ID，ENSG00000051128)或其 他生物种同源物等。HOMER3基因可以通过例如Xiao，B.等，2001年、 Neuron、第21卷、p.707-716中记载的方法获得。HOMER3基因的表 达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“GPR2基因”或“GPR2”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号33)表示的C -C Chemokine Receptor Type 10基因(DNA)、其同源物、变异体及 衍生物等的基因(DNA)。具体而言，包括序列号33所述的GPR2基 因(Ensembl Gene ID，ENSG00000177032)或其他生物种同源物等。 GPR2基因可以通过例如Marchese，A.等，1994年、Genomics、第23 卷、p.609-618中记载的方法获得。GPR2基因的表达变化可以成为肾 癌转移的指标尚属未知。
本说明书中使用的“FLJ12442基因”或“FLJ12442”的术语，在 没有被序列号定义的情况下，包括编码特定碱基序列(序列号34)表 示的基因(DNA)、其同源物、变异体及衍生物等的基因(DNA)。 具体而言，包括序列号34所述的FLJ12442基因(Ensembl Gene ID， ENSG00000168268)或其他生物种同源物等。FLJ12442基因可以通过 例如Ota，T.等，2004年、Nature Genetics、第36卷、p.40-45中记载 的方法获得。FLJ12442基因的表达变化可以成为肾癌转移的指标尚属 未知。
本说明书中使用的“XLKD1基因”或“XLKD1”的术语，在没 有被序列号定义的情况下，包括编码特定碱基序列(序列号35)表示 的Extracellular Link Domain Containing 1基因(DNA)、其同源物、 变异体及衍生物等的基因(DNA)。具体而言，包括序列号35所述的 XLKD1基因(Ensembl Gene ID，ENSG00000133800)或其他生物种 同源物等。XLKD1基因可以通过例如Banerji，S.等，1999年、Journal of Cellular Biology、第144卷、p.1789-801中记载的方法获得。XLKD1 基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“CASKIN2基因”或“CASKIN2”的术语，在 没有被序列号定义的情况下，包括编码特定碱基序列(序列号36)表 示的CASK-Interacting Protein 2基因(DNA)、其同源物、变异体及 衍生物等的基因(DNA)。具体而言，包括序列号36所述的CASKIN2 基因(Ensembl Gene ID，ENSG00000177303)或其他生物种同源物等。 CASKIN2基因可以通过例如Strausberg，R.L.等，2002年、Proceedings ofthe National Academic Sciences U.S.A.、第99卷、p.16899-16903中 记载的方法获得。CASKIN2基因的表达变化可以成为肾癌转移的指标 尚属未知。
本说明书中使用的“COL5A2基因”或“COL5A2”的术语，在没 有被序列号定义的情况下，包括编码特定碱基序列(序列号37)表示 的Collagen Alpha 2(V)Chain基因(DNA)、其同源物、变异体及 衍生物等的基因(DNA)。具体而言，包括序列号37所述的COL5A2 基因(Ensembl Gene ID，ENSG00000179877)或其他生物种同源物等。 COL5A2基因可以通过例如Burgeson，R.E.等，2002年、Proceedings of the National Academic Sciences U.S.A.、第73卷、p.2579-2583中记载 的方法获得。COL5A2基因的表达变化可以成为肾癌转移的指标尚属 未知。
本说明书中使用的“BRD3基因”或“BRD3”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号38)表示的 Bromodomain-Containing Protein 3基因(DNA)、其同源物、变异 体及衍生物等的基因(DNA)。具体而言，包括序列号38所述的BRD3 基因(Ensembl Gene ID，ENSG00000169925)或其他生物种同源物等。 BRD3基因可以通过例如Nomura，N.L.等，1994年、DNA Research、 第1卷、p.223-229中记载的方法获得。BRD3基因的表达变化可以成 为肾癌转移的指标尚属未知。
本说明书中使用的“ATP6V0A4基因”或“ATP6V0A4”的术语， 在没有被序列号定义的情况下，包括编码特定碱基序列(序列号39) 表示的ATPase，H+Transporting，Lysosomal V0 Subunit A ISOFORM 4基因(DNA)、其同源物、变异体及衍生物等的基因(DNA)。具 体而言，包括序列号39所述的ATP6V0A4基因(Ensembl Gene ID， ENSG00000105929)或其他生物种同源物等。ATP6V0A4基因可以通 过例如Smith，A.N.等，2000年、Nature Genetics、第26卷、p.71-75 中记载的方法获得。ATP6V0A4基因的表达变化可以成为肾癌转移的 指标尚属未知。
本说明书中使用的“PRODH2基因”或“PRODH2”的术语，在 没有被序列号定义的情况下，包括编码特定碱基序列(序列号40)表 示的Nephrin基因(DNA)、其同源物、变异体及衍生物等的基因 (DNA)。具体而言，包括序列号40所述的PRODH2基因(Ensembl Gene ID，ENSG00000161270)或其他生物种同源物等。PRODH2基 因可以通过例如Chakravarti，A.等，2002年、Proceedings of the National Academic Sciences U.S.A.、第99卷、p.4755-4756中记载的方法获得。 PRODH2基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“EPHB2基因”或“EPHB2”的术语，在没有 被序列号定义的情况下，包括编码特定碱基序列(序列号41)表示的 Ephrin Type-B Receptor 2基因(DNA)、其同源物、变异体及衍生 物等的基因(DNA)。具体而言，包括序列号41所述的EPHB2基因 (Ensembl Gene ID，ENSG00000133216)或其他生物种同源物等。 EPHB2基因可以通过例如Chan，J.等，1991年、Oncogene、第6卷、 p.1057-1061中记载的方法获得。EPHB2基因的表达变化可以成为肾 癌转移的指标尚属未知。
本说明书中使用的“LYAR基因”或“LYAR”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号42)表示的 Hypothetical Protein FLJ20425基因(DNA)、其同源物、变异体及衍 生物等的基因(DNA)。具体而言，包括序列号42所述的LYAR基因 (Ensembl Gene ID，ENSG00000145220)或其他生物种同源物等。 LYAR基因可以通过例如Su，L.等，1993年、Genes Development、第7 卷、p.735-748中记载的方法获得。LYAR基因的表达变化可以成为 肾癌转移的指标尚属未知。
本说明书中使用的“COX6B基因”或“COX6B”的术语，在没 有被序列号定义的情况下，包括编码特定碱基序列(序列号43)表示 的Cytochrome C Oxidase Polypeptide VIB基因(DNA)、其同源物、 变异体及衍生物等的基因(DNA)。具体而言，包括序列号43所述的 COX6B基因(Ensembl Gene ID，ENSG00000126267)或其他生物种 同源物等。COX6B基因可以通过例如Taanman，J-W.等，1989年、 Nucleic Acids Research、第17卷、p.1766中记载的方法获得。COX6B 基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“PRH1基因”或“PRH1”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号44)表示的 Salivary Acidic Proline-Rich Phosphoprotein 1/2基因(DNA)、其 同源物、变异体及衍生物等的基因(DNA)。具体而言，包括序列号 44所述的PRH1基因(Ensembl Gene ID，ENSG00000176621)或其他 生物种同源物等。PRH1基因可以通过例如Oppenheim，F.G.等，1971 年、Biochemistry、第10卷、p.4233-4238中记载的方法获得。PRH1 基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“LAPTM5基因”或“LAPTM5”的术语，在 没有被序列号定义的情况下，包括编码特定碱基序列(序列号45)表 示的Lysosomal-Associated Multitransmembrane Protein基因(DNA)、 其同源物、变异体及衍生物等的基因(DNA)。具体而言，包括序列 号45所述的LAPTM5基因(Ensembl Gene ID，ENSG00000162511)或 其他生物种同源物等。LAPTM5基因可以通过例如Adra，C.N.等，1996 年、Genomics、第35卷、p.328-337中记载的方法获得。LAPTM5基 因的表达变化可以成为肾癌转移的指标尚属未知，但已经推定可以成 为肾癌的标记物(国际公开WO2005/24603)。
本说明书中使用的“RPS6KA4基因”或“RPS6KA4”的术语，在 没有被序列号定义的情况下，包括编码特定碱基序列(序列号46)表 示的Ribosomal Protein S6 Kinase，90KDA，Polypeptide 4基因(DNA)、 其同源物、变异体及衍生物等的基因(DNA)。具体而言，包括序列 号46所述的RPS6KA4基因(Ensembl Gene ID，ENSG00000162302) 或其他生物种同源物等。RPS6KA4基因可以通过例如Pierrat，B.等， 1998年、Journal of Biological Chemistry、第273卷、p.29661-29671 中记载的方法获得。RPS6KA4基因的表达变化可以成为肾癌转移的指 标尚属未知。
本说明书中使用的“GCC2基因”或“GCC2”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号47)表示的GRIP and Coiled-Coil Domain Containing 2基因(DNA)、其同源物、变异 体及衍生物等的基因(DNA)。具体而言，包括序列号47所述的GCC2 基因(Ensembl Gene ID，ENSG00000144055)或其他生物种同源物等。 GCC2基因可以通过例如Eichmuller，S.等，2001年、Proceedings of the National Academic Sciences U.S.A.、第98卷、p.629-634中记载的方 法获得。GCC2基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“FGF2基因”或“FGF2”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号48)表示的 Heparin-Binding Growth Factor 2基因(DNA)、其同源物、变异体 及衍生物等的基因(DNA)。具体而言，包括序列号48所述的FGF2 基因(Ensembl Gene ID，ENSG00000138685)或其他生物种同源物等。 FGF2基因可以通过例如Abraham，J.等，1986年、Science、第233卷、 p.545-548中记载的方法获得。如Miyake，H.等，1996年、Cancer Research、第56卷、p.2440-2445所示，已公知FGF2基因的表达变化 可以成为肾癌转移的指标。
本说明书中使用的“MMP14基因”或“MMP14”的术语，在没 有被序列号定义的情况下，包括编码特定碱基序列(序列号49)表示 的Matrix Metalloproteinase-14基因(DNA)、其同源物、变异体及 衍生物等的基因(DNA)。具体而言，包括序列号49所述的MMP14 基因(Ensembl Gene ID，ENSG00000157227)或其他生物种同源物等。 MMP14基因可以通过例如Sato，H.等，1994年、Nature、第370卷、p.61 -65中记载的方法获得。如Kitagawa，Y.等，1999年、Journal of Urology、 第162卷、p.905-909等所示，已公知MMP14基因的表达变化可以成 为肾癌转移的指标。
本说明书中使用的“ERBB2基因”或“ERBB2”的术语，在没有 被序列号定义的情况下，包括编码特定碱基序列(序列号50)表示的 Receptor Protein-Tyrosine Kinase ERBB-2基因(DNA)、其同源物、 变异体及衍生物等的基因(DNA)。具体而言，包括序列号50所述的 ERBB2基因(Ensembl Gene ID，ENSG00000141736)或其他生物种 同源物等。ERBB2基因可以通过例如Yang-Feng，T.L.等，1985年、 Citogenetic Cell Genetics、第40卷、p.784中记载的方法获得。如Freeman， M.R.等，1989年、Cancer Research、第49卷、p.6221-6225所示，已 公知ERBB2基因的表达变化可以成为肾癌转移的指标。
对于本说明书中记载的其它基因或多肽，在下述详细说明中适当 地说明。
本发明提供一种对诊断、检测、确定或预测肾癌的存在或肾癌转 移、及对治疗肾癌有用的疾病确定用组合物、及使用该组合物用于诊 断、检测、确定或预测肾癌及肾癌转移的方法，因此，本发明通过提 供一种特异性地且高预测率的、及迅速且简便地、对肾癌的存在或肾 癌转移进行检测、确定或预测方法，具有显著的作用效果。
另外，本发明的肾癌标记物中的一部分也可能出现在肾癌患者的 血液等生物试样中，但在健康人中几乎或完全没有，因此，也具有下 述作用效果，即，只需以上述标记物的存在或量为指标，即可在例如 血液中容易地检测肾癌。
本发明通过将本发明的检测肾癌的探针和检测肾癌转移的探针 组合，能够进行有利于肾癌患者的预后管理的诊断。
附图说明
[图1]表示手术时未诊断出转移至肾脏以外器官的患者组(M＝0) 和诊断出转移的患者组(M＝1)分别采用Kaplan-Meier法绘制的生 存曲线。纵轴表示生存率，横轴表示手术后的年数(年)。5年生存 率在M＝0时为96％、M＝1时为13％。
[图2]表示组合对应于表1所述基因的序列号1～19、48的多核苷酸 用作DNA芯片时预后良好的患者预测率、及组合序列号20～47、49、 50的多核苷酸用作DNA芯片时的预后不良的患者预测率。纵轴表示能 预测预后良好的患者/预后不良的患者的概率(预测率)、横轴表示 预测预后良好的患者/预后不良的患者所需的基因的总数。实线表示 预后良好的患者的预测概率，虚线表示预后不良的患者的预测概率。
推测如果能够发现多个有效的肾癌标记物，则肾癌的治疗及转移 性肾癌的治疗能够取得很大进步。特别是，转移性肾癌患者多为预后 不良，但通过在诊断时获知是否转移，可进行有效治疗，能够期待改 善预后。
本发明的目的在于提供一种对肾癌诊断、肾癌转移(或预后)的 诊断、及肾癌治疗有用的疾病确定用组合物、试剂盒或DNA芯片。
本发明的目的还在于提供使用上述组合物、试剂盒或DNA芯片来 检测、确定或者预测肾癌的存在或转移的方法。
作为标记物的寻找方法，可以举出下述方法，即，观察肾癌患者 的预后，通过某种方法对来自预后良好的肾癌患者的肾癌细胞和来自 预后不良的肾癌患者的肾癌细胞中的基因表达或蛋白质表达、或细胞 代谢产物等的量进行比较的方法，或对来自预后良好的患者的含有肾 癌细胞的组织的体液或来自预后不良的患者的含有肾癌细胞的组织 的体液中所含的基因、蛋白质、代谢产物等的量进行测定的方法。
近年，使用DNA阵列进行的基因表达量分析，被特别广泛地用作 寻找上述标记物的方法。DNA阵列中固定有使用与数百至数万种基因 对应的碱基序列的探针。通过将受试试样添加到DNA阵列中，使试样 中的基因与探针结合，利用某种方法测定结合量，由此可以知道受试 试样中的基因量。对应于固定在DNA阵列上的探针的基因可以自由选 择，另外，受试试样使用来自预后良好、及预后不良的患者的肾癌细 胞，通过比较试样中的表达基因量，能够推断可成为肾癌转移、及/ 或肾癌患者预后预测标记物的基因。
为了解决上述课题，本发明人等通过DNA阵列对来自预后良好的 肾癌患者的肾癌组织中及来自预后不良的肾癌患者的肾癌组织中的 基因表达进行分析。并且，以由DNA阵列测定的基因表达量对各患者 组手术后的经时生存率变化的影响为指标，选择能够判别来自预后良 好的肾癌患者的肾癌组织及来自预后不良的肾癌患者的肾癌组织、及 /或能够判别肾癌是否转移的基因，从而完成本发明。
本发明具有以下特征。
(1)一种用于体外检测、确定或预测受试者的肾癌的存在或转 移的组合物，其中含有选自下述I组及/或II组中的1个或2个以上探 针：
I组：由下述(a)～(e)构成的多核苷酸：
(a)由序列号1～10、12～20、22～47表示的碱基序列构成的多 核苷酸、其变异体、或其含有15个以上连续碱基的片段，
(b)含有序列号1～10、12～20、22～47表示的碱基序列的多核 苷酸，
(c)由与序列号1～10、12～20、22～47表示的碱基序列互补的 碱基序列构成的多核苷酸、其变异体、或其含有15个以上连续碱基的 片段，
(d)含有与序列号1～10、12～20、22～47表示的碱基序列互补 的碱基序列的多核苷酸，及
(e)与上述(a)～(d)中的任一个多核苷酸在严格条件下杂交 的多核苷酸、或其含有15个以上连续碱基的片段
II组：由下述(f)～(h)构成的抗体、其片段或者其化学修饰衍 生物：
(f)与含有由序列号1～10、12～20、22～47表示的碱基序列编 码的氨基酸序列的多肽、或含有序列号101～110、112～120、122～ 147表示的氨基酸序列的多肽、它们的变异体、或者它们的片段中的 至少1个特异性结合的抗体、其片段或者其化学修饰衍生物，
(g)与含有序列号151、153、155～160表示的氨基酸序列的多 肽、它们的变异体、或者它们的片段中的至少1个特异性结合的抗体、 其片段或者其化学修饰衍生物，及
(h)与含有序列号161～190表示的氨基酸序列的多肽、它们的 变异体、或者它们的片段中的至少1个特异性结合的抗体、其片段或 者其化学修饰衍生物。
(2)如(1)所述的组合物，其中，利用上述I组及II组(f)的各 探针能够检测、确定或预测肾癌的存在或转移。
(3)如(1)所述的组合物，其中，利用上述II组(g)、(h) 的各探针能够检测、确定或预测肾癌的存在。
(4)如(1)所述的组合物，其中，所述多核苷酸为DNA或RNA。
(5)如(1)所述的组合物，其中，所述I组中的片段为含有60 个以上连续碱基的多核苷酸。
(6)如(1)所述的组合物，其中，所述I组中的片段为在序列号 1～10、12～20、22～47中任一个表示的碱基序列中，分别含有序列 号51～60、62～70、72～97中任一个表示的碱基序列的多核苷酸、或 含有与该多核苷酸的序列互补的碱基序列的多核苷酸。
(7)如(1)所述的组合物，其中，所述I组中的片段是含有序列 号51～60、62～70、72～97中任一个表示的碱基序列、或与上述碱基 序列互补的碱基序列的多核苷酸。
(8)如(1)所述的组合物，所述组合物除含有上述I组的探针之 外，还含有选自由序列号11、21、48～50表示的碱基序列构成的多核 苷酸、由其互补序列构成的多核苷酸、与上述多核苷酸在严格条件下 杂交的多核苷酸、或上述多核苷酸的含有15个以上连续碱基的片段中 的1个或2个以上多核苷酸作为探针。
(9)如(8)所述的组合物，其中，所述片段为含有60个以上连 续碱基的多核苷酸。
(10)如(8)所述的组合物，其中，所述片段为在序列号11、 21、48～50表示的碱基序列中，含有序列号61、71、98～100表示的 碱基序列的多核苷酸、或含有与该多核苷酸的序列互补的碱基序列的 多核苷酸。
(11)如(8)所述的组合物，其中，所述片段是含有序列号61、 71、98～100表示的碱基序列、或与其互补的碱基序列的多核苷酸。
(12)如(1)所述的组合物，所述组合物除含有上述II组(f) 的探针之外，还含有与序列号111、121、148～150表示的多肽、其变 异体或其片段中的至少1个特异性结合的抗体、其片段或其化学修饰 衍生物。
(13)如(1)所述的组合物，所述组合物除含有上述II组(g) 的探针之外，还含有与具有序列号152、154、191表示的氨基酸序列 的多肽、其变异体或其片段中的至少1个特异性结合的抗体、其片段 或其化学修饰衍生物。
(14)如(1)所述的组合物，所述组合物除含有上述II组(h) 的探针之外，还含有与具有序列号192～197表示的氨基酸序列的多 肽、其变异体或其片段中的至少1个特异性结合的抗体、其片段或其 化学修饰衍生物。
(15)如(1)、(12)、(13)或(14)所述的组合物，其中， 所述多肽或变异体的片段含有由至少7个氨基酸构成的表位。
(16)如权利要求(1)、(12)、(13)或(14)所述的组合 物，其中，所述抗体为多克隆抗体、单克隆抗体、合成抗体、重组抗 体、多重特异性抗体或单链抗体。
(17)如(1)所述的组合物，其中组合含有选自上述I组或II组 (f)、(g)、(h)中的2个以上探针。
(18)一种用于体外检测、确定或预测受试者的肾癌的存在或转 移的试剂盒，所述试剂盒含有选自上述(1)中定义的I组或II组(f)、 (g)、(h)中的1个或2个以上探针。
(19)如(18)所述的试剂盒，其中还含有由序列号11、21、48～ 50表示的碱基序列构成的多核苷酸、由其互补序列构成的多核苷酸、 与上述多核苷酸在严格条件下杂交的多核苷酸、或上述多核苷酸的含 有15个以上连续碱基的片段作为探针。
(20)如(18)或(19)所述的试剂盒，其中，所述探针为由序 列号1～10、11、12～20、21、22～47、48～50中任一个表示的碱基 序列构成的多核苷酸、由其互补序列构成的多核苷酸、与上述多核苷 酸在严格条件下杂交的多核苷酸、或上述多核苷酸的含有15个以上连 续碱基的片段。
(21)如(18)～(20)中任一项所述的试剂盒，其中，所述I 组中的片段为含有60个以上连续碱基的多核苷酸。
(22)如(18)～(20)中任一项所述的试剂盒，其中，所述I 组中的片段为在序列号1～10、11、12～20、21、22～47、48～50中 任一个表示的碱基序列中含有60个以上连续碱基的多核苷酸，并且分 别含有序列号51～60、61、62～70、71、72～97、98～100中任一个 表示的碱基序列的多核苷酸、或含有与该多核苷酸的序列互补的碱基 序列的多核苷酸。
(23)如(18)～(20)中任一项所述的试剂盒，其中，所述I 组中的片段为含有序列号51～60、61、62～70、71、72～97、98～100 中任一个表示的碱基序列、或与其互补的碱基序列的多核苷酸。
(24)如(18)～(20)中任一项所述的试剂盒，其中，所述I 组中的片段为由序列号51～60、61、62～70、71、72～97、98～100 中任一个表示的碱基序列构成的多核苷酸。
(25)如(18)所述的试剂盒，其中含有2个以上至全部的具有 序列号51～60、61、62～70、71、72～97、98～100表示的碱基序列 或其互补序列的多核苷酸。
(26)如(18)所述的试剂盒，所述试剂盒除含有上述II组(f) 的探针之外，还含有与序列号111、121、148～150表示的多肽、其变 异体或其片段中的至少1个特异性结合的抗体、其片段或其化学修饰 衍生物。
(27)如(18)所述的试剂盒，所述试剂盒除含有上述II组(g) 的探针之外，还含有与序列号152、154、191表示的多肽、其变异体 或其片段中的至少1个特异性结合的抗体、其片段或其化学修饰衍生 物。
(28)如(18)所述的试剂盒，所述试剂盒除含有上述II组(h) 的探针之外，还含有与序列号192～197表示的多肽、其变异体或其片 段中的至少1个特异性结合的抗体、其片段或其化学修饰衍生物。
(29)如(18)所述的试剂盒，其中，所述探针单独或组合包装 在不同容器中。
(30)一种用于体外检测、确定或预测受试者的肾癌的存在或转 移的DNA芯片，所述DNA芯片含有选自上述(1)中定义的I组(a)～ (e)中的1个或2个以上探针。
(31)如(30)所述的DNA芯片，其中还含有由序列号11、21、 48～50表示的碱基序列构成的多核苷酸、其变异体及/或其片段。
(32)如(30)所述的DNA芯片，其中含有2个以上～全部的具 有序列号51～60、61、62～70、71、72～97、98～100表示的碱基序 列或其互补序列的多核苷酸。
(33)一种体外检测、确定或预测肾癌的存在或转移的方法，其 中使用选自上述1中定义的I组及/或II组(f)、(g)、(h)中的探 针，体外测定在来自受试者的生物试样中1种或多种肾癌相关靶核酸 的存在或存在量或表达量。
(34)如(33)所述的方法，其中，使用DNA芯片进行所述测定。
(35)如(33)所述的方法，其中，以与对照试样相比的变化为 指标，检测、确定或预测所述肾癌的存在或转移。
(36)如(33)所述的方法，其中，所述测定通过免疫学方法进 行。
(37)如(36)所述的方法，其中，所述采用免疫学方法的测定 使用所述II组(f)、(g)或(h)的抗体、其片段、或其化学修饰衍 生物进行。
(38)如(37)所述的方法，其中，所述抗体、其片段、或其化 学修饰衍生物被标记。
(39)如(33)所述的方法，其中，所述生物试样是来自肾的组 织或细胞、血液、血浆、血清、或者尿。
(40)一种体外检测、确定或预测肾癌的存在或转移的方法，所 述方法包括使用上述(1)所述的组合物、上述(18)所述的试剂盒、 或上述(30)所述的DNA芯片，体外测定在来自受试者的生物试样中 的1个或多个肾癌相关靶核酸的存在或存在量或表达量。
(41)一种方法，所述方法使用选自上述(1)中定义的I组中的 探针、或者、含有该探针的、上述(1)所述的组合物、上述(18) 所述的试剂盒、或上述(30)所述的DNA芯片，通过将来自受试者的 肾癌细胞生物试样中靶核酸的表达水平，与来自预后不良的肾癌患者 群体的肾癌细胞中靶核酸的表达水平及/或来自预后良好的患者群 体的肾癌细胞中靶核酸的表达水平相比较，体外预测受试者的预后、 及/或肾癌是否转移，其中，该靶核酸可以通过该组合物、试剂盒或 DNA芯片中含有的多核苷酸、其变异体或其片段进行检测，并且，来 自受试者的该靶核酸的表达水平与预后良好的肾癌患者群体的表达 水平及/或预后不良的患者群体的表达水平相比发生变化时，分别确 定受试者的预后恶化或受试者的预后良好、及/或确定肾癌发生转移 或肾癌没有发生转移。
(42)如(41)所述的方法，其中，使用DNA芯片。
(43)如(41)或(42)所述的方法，所述方法包含如下步骤：
第1步骤：使用选自上述(1)中定义的I组中的探针、或者、含有 该探针的、上述(1)所述的组合物、上述(18)所述的试剂盒、或 上述(30)所述的DNA芯片，体外测定多个生物试样中靶核酸的表达 水平，所述生物试样是已知的来自预后不良的患者的肾癌细胞及/或 来自预后良好的患者的肾癌细胞；
第2步骤：以所述第1步骤得到的该靶核酸的表达水平的测定值作 为训练样本制作辨别式(支持向量机support vector machine)；
第3步骤：与第1步骤相同地体外测定在来自受试者肾癌的生物试 样中该靶核酸的表达水平；
第4步骤：将第3步骤得到的该靶核酸的表达水平的测定值代入所 述第2步骤得到的辨别式中，以由该辨别式得到的结果为基础，预测 受试者的预后、及/或确定来自受试者的肾癌是来自有转移的患者的 肾癌、或是来自无转移的患者的肾癌；
此处，该靶核酸是可通过该组合物、试剂盒或DNA芯片中含有的 多核苷酸、其变异体或其片段进行检测的靶核酸。
(44)选自上述(1)中定义的I组及/或II组中的探针、或者、 含有该探针的、上述(1)所述的组合物、上述(18)所述的试剂盒、 或上述(30)所述的DNA芯片在体外检测、确定或预测来自受试者的 生物试样中肾癌的存在或转移中的用途。
定义
本说明书中使用的用语具有以下定义。
本说明书中所谓“探针”，是指核酸、抗体或二者的相当物，用 于检测、确定或者预测肾癌的存在或转移，能够与为肾癌相关标记物 的特定的基因类或由该基因类编码的多肽类结合。
核苷酸、多核苷酸、氨基酸、肽、多肽、蛋白质等用简写符号所 表达的含义是本技术领域中惯用的意思及含义。
本说明书中，所谓“多核苷酸”是指包括RNA及DNA两者的核酸。 需要说明的是，上述DNA包括cDNA、基因组DNA、及合成DNA中的 任一种。另外，上述RNA包括总RNA、mRNA、rRNA、及合成RNA 中的任一种。另外，本说明书中，多核苷酸可以与核酸互换使用。
本说明书中，所谓“cDNA”包括与由基因表达生成的RNA互补 的序列的全长DNA链、及由其部分序列构成的DNA片段。cDNA可以 以RNA为模板，通过使用聚T引物的RT-PCR(逆转录酶-聚合酶链 反应)进行合成。
本说明书中，所谓“基因”，不仅包括双链DNA，还包括构成双 链DNA的正链(或有义链)或互补链(或反义链)等单链DNA。另外， 对其长度没有特殊的限定。所以，本说明书中只要没有特殊说明，“基 因”是指包括人基因组DNA在内的双链DNA、包括cDNA在内的单链 DNA(正链)、具有与该正链互补的序列的单链DNA(互补链)、及 它们的片段中的任一种。另外该“基因”不仅包括特定碱基序列(或 序列号)表示的“基因”，还包括编码与上述基因编码的蛋白质的生 物学功能相同的蛋白质、例如同源物(homolog)、剪接变体等变异 体、及衍生物的“基因”。作为编码所述同源物、变异体或衍生物 的“基因”，具体而言可以举出具有在下述的严格条件下与上述序列 号1～50表示的任一个特定碱基序列的互补序列杂交的碱基序列的“基 因”。
例如，作为来自人的蛋白质的同源物(homolog)或其编码基因， 可以举出与该蛋白质或其编码人基因对应的其它生物种的蛋白质或 基因，上述蛋白质或基因同源物能够通过HomoloGene(http:// www.ncbi.nlm.nih.gov/homoloGene/)鉴定。具体而言，可 以将特定的人类氨基酸或碱基序列代入BLAST程序(Karlin，S.等、 Proceedings of the National Academic Sciences U.S.A.、1993年、第90 卷、p.5873-5877、http://www.ncbi.nlm.nih.gov/BLAST/)，得 到一致(得分最高、E值为0且同一性显示为100％)序列的登录号 (accession number)。作为BLAST程序，已知BLASTN(基因)、 BLASTX(蛋白质)等。例如，基因检索时，将由上述BLAST检索得 到的登录号输入UniGene(http://www.ncbi.nlm.nih.gov/UniGene/)， 将得到的UniGeneClusterID(以Hs.表示的序号)输入HomoloGene。 从作为结果得到的表示其它生物种基因与人类基因的基因同源物的 相关性的列表中选择其它生物种的基因作为与由特定碱基序列表示 的人类基因对应的基因同源物。另外在此方法中，也可以使用FASTA 程序(http://www.ddbj.nig.ac.jp/search/fasta-e.html)代替BLAST 程序。
需要说明的是，对“基因”的功能区域没有限定，例如可以含有表 达控制区域、编码区域、外显子或内含子。
本说明书中，所谓“转录产物”，是指以基因的DNA序列为模板 合成的信使RNA(mRNA)。RNA聚合酶与位于基因上游的称为启动 子的部位结合，使核糖核苷酸与3’末端结合，使其与DNA的碱基序列 互补，合成信使RNA。此信使RNA不仅含有基因本身，还含有包括表 达控制区域、编码区域、外显子或内含子在内的从转录起点至聚A序 列末端的全长序列。
本说明书中，所谓“翻译产物”，表示无论转录合成的信使RNA 接受/不接受剪接等修饰，都基于其信息而合成的蛋白质。在信使RNA 的翻译过程中，首先，核糖体与信使RNA结合，然后，根据信使RNA 的碱基序列结合氨基酸，从而合成蛋白质。
本说明书中，所谓“引物”包括能特异性识别、扩增基因表达产 生的RNA或来自该RNA的多核苷酸的连续的多核苷酸及/或与其互补 的多核苷酸。
此处，所谓互补的多核苷酸(互补链、反链)是指基于A：T(U)、 G：C的碱基配对，与由序列号定义的碱基序列构成的多核苷酸的全 长序列、或其部分序列(此处，为了便于说明，将上述序列称为正链) 具有碱基互补关系的多核苷酸。其中，所述互补链不只限于形成与作 为对象的正链的碱基序列完全互补的序列，也可以是具有能与作为对 象的正链在严格条件下杂交的互补关系的序列。
本说明书中，所谓“严格条件”，是指相对于探针对其它序列的 杂交，探针以可检测性更大的程度(例如，比背景至少大2倍)与其 靶序列杂交的条件。严格条件具有序列依赖性，因进行杂交的环境的 不同而不同。通过控制杂交及/或清洗条件为严格条件，可以鉴定与探 针100％互补的靶序列。
在本说明书中，“变异体”为核酸时，是指起因于多态性、突变、 转录时的选择剪接等的天然变异体、同源物、或以遗传密码的简并性 为基础的变异体、或在序列号1～50表示的碱基序列或其部分序列中缺 失、置换、添加或插入1个以上、优选1个或几个碱基的变异体、或者 与该碱基序列或其部分序列具有约80％以上、约85％以上、优选约90 ％以上、更优选约95％以上、约97％以上、约98％以上、或约99％以 上的同源性百分比的变异体、或者在上述定义的严格条件下与含有该 碱基序列或其部分序列的多核苷酸或寡核苷酸杂交的核酸，另一方 面，变异体为蛋白质或肽时，是指序列号101～197表示的氨基酸序列 或其部分序列中缺失、置换、添加或插入1个以上、优选1个或几个氨 基酸的变异体、或者与该氨基酸序列或其部分序列具有约80％以上、 约85％以上、优选约90％以上、较优选约95％以上、约97％以上、约 98％以上、或约99％以上的同源性百分比的变异体。
本说明书中，所谓“数个”是指约10、9、8、7、6、5、4、3或2 个以下的整数。
本说明书中，“同源性百分比”可以通过使用采用上述BLAST或 FASTA的蛋白质或基因检索系统，导入空位(gap)而进行确定(Karlin， S.等，1993年、Proceedings of the National Academic Sciences U.S.A.， 第90卷，P.5873-5877；Altschu1，S.F.等，1990年，Journal of Molecular Biology，第215卷，p.403-410；Pearson，W.R.等，1988年，Proceedings ofthe National Academic Sciences U.S.A.，第85卷，p.2444-2448)。
本说明书中，所谓“衍生物”为核酸时，是指通过荧光团等进行标 记的衍生物、含有修饰核苷酸(例如，含有卤素、甲基等烷基、甲氧 基等烷氧基、硫代、羧甲基等基团的核苷酸，及进行了碱基的再构建、 双键的饱和、脱氨基化、硫分子对氧分子的取代等的核苷酸等)的衍 生物等，另一方面，“衍生物”为蛋白质(包括抗体)时，是指通过酶、 荧光团、放射性同位素等标记产生的标记化衍生物、或乙酰化、酰化、 烷基化、磷酸化、硫酸化、糖基化衍生物等化学修饰衍生物。
本说明书中，所谓“诊断(或检测或确定)用组合物”或“疾病 确定用组合物”，是指为了预测肾癌患者的预后、及/或诊断是否罹 患肾癌、罹患程度、肾癌有无转移、或有无改善或改善程度，或为了 筛选对肾癌的预防、改善或治疗有用的候选物质，而直接或间接使用 的组合物。其中，包括能特异性识别或结合下述基因的核酸、寡核苷 酸及多核苷酸，所述基因与肾癌的罹患相关、在生物体内特别是在肾 组织内的表达发生变化，还包括能检测作为该基因翻译产物的蛋白质 的抗体等。上述核苷酸、寡核苷酸及多核苷酸，基于上述性质，能够 有效地用作用于检测在生物体内、组织或细胞内等表达的上述基因的 探针，或用于扩增在生物体内表达的上述基因的引物。本说明书中使 用的“组合物”，是指含有与本发明相关的单独探针、或2个以上不 同探针的混合物的组合物，该组合物可以为包括固体(例如冻干物 等)、溶液(例如水溶液、缓冲溶液等)的任意形态。另外，必要时， 在不对分析产生影响的条件下，该组合物还可以含有稳定剂、防腐剂 等添加剂。
本说明书中，作为检测、诊断对象的“生物试样”是指由生物体 采集的试样(或标本)，在所述试样中，随肾癌的发展，本发明的靶 基因表达发生变化、或者本发明靶多肽的量与正常对照相比发生变 化。生物试样包括例如肾组织、来自其周围的淋巴结或怀疑发生转移 的其他脏器等的组织、来自上述组织的细胞、及血液等体液等。
在本说明书中，“特异性结合”是指抗体或其片段只与本发明的靶 多肽、其变异体或其片段形成抗原-抗体复合体，而与其它肽性或多 肽性物质实质上不形成复合体。此处，“实质上”是指虽然程度小，但 能引起非特异性复合体的形成。
在本说明书中，“表位”是指在本发明的靶多肽、其变异体或其片 段中，具有抗原性或免疫原性的部分氨基酸区域(抗原决定簇)。表 位通常由至少5个氨基酸、优选至少7个氨基酸、更优选至少10个氨基 酸构成。
本说明书中，所谓“预后”，表示由采用Kaplan-Meier法(例如 BMJ(1998)317：1572)绘制的生存曲线表示的生存概率。另外， 所谓“预后良好”的患者组，是指根据某些临床信息将肾癌患者分类， 分别采用Kaplan-Meier法绘制生存曲线后，通过某些统计方法检定其 差异，具有差异显著(p＜0.05)的高生存率的组。相同地所谓“预后 不良”的患者组，是指根据某些临床信息将肾癌患者分类，分别采用 Kaplan-Meier法绘制生存曲线后，通过某些统计方法检定其差异，具 有差异显著(p＜0.05)的低生存率的组。癌是否转移是对患者预后产 生影响的要素之一，因此，预后预测与癌转移的预测部分相关。
本说明书中使用的“PABPN1基因”或“PABPN1”的术语，在没 有被序列号定义的情况下，包括编码由特定碱基序列(序列号1)表 示的Poly(A)-Binding Protein，Nuclear 1基因(DNA)、其同源物、 变异体及衍生物等的基因(DNA)。具体而言，包括序列号1所述的 PABPN1基因(Ensembl Gene ID，ENSG00000100836)或其他生物种 同源物等。PABPN1基因可以通过例如Brais，B.等，1998年、Nature genetics、第18卷、p.164-167中记载的方法获得。PABPN1基因的表 达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“PINK1基因”或“PINK1”的术语，在没有 被序列号定义的情况下，包括编码特定碱基序列(序列号2)表示的 PTEN Induced Putative Kinase 1基因(DNA)、其同源物、变异体及 衍生物等的基因(DNA)。具体而言，包括序列号2所述的PINK1基 因(Ensembl Gene ID，ENSG00000180056)或其他生物种同源物等。 PINK1基因可以通过例如Unoki，M.等，2001年、Oncogene、第20卷、 p.4457-4465中记载的方法获得。PINK1基因的表达变化可以成为肾 癌转移的指标尚属未知。
本说明书中使用的“TFF2基因”或“TFF2”的术语，在没有被序 列号定义的情况下，包括编码特定碱基序列(序列号3)表示的Trefoil Factor 2基因(DNA)、其同源物、变异体及衍生物等的基因(DNA)。 具体而言，包括序列号3所述的TFF2基因(Ensembl Gene ID，ENSG 00000160181)或其他生物种同源物等。TFF2基因可以通过例如 Tomasetto，C.等，1990年、EMBO Journal、第9卷、p.407-414中记 载的方法获得。TFF2基因的表达变化可以成为肾癌转移的指标尚属未 知。
本说明书中使用的“EIF3S9基因”或“EIF3S9”的术语，在没有 被序列号定义的情况下，包括编码特定碱基序列(序列号4)表示的 Eukaryotic Translation Initiation Factor 3 Subunit 9基因(DNA)、其同 源物、变异体及衍生物等的基因(DNA)。具体而言，包括序列号4 所述的EIF3S9基因(Ensembl Gene ID，ENSG00000106263)或其他 生物种同源物等。EIF3S9基因可以通过例如Methot，N.等，1997年、 Journal of Biological Chemistry、第272卷、p.1110-1116中记载的方法 获得。EIF3S9基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“MAX基因”或“MAX”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号5)表示的MAX Protein基因(DNA)、其同源物、变异体及衍生物等的基因(DNA)。 具体而言，包括序列号5所述的MAX基因(Ensembl Gene ID，ENSG 00000125952)或其他生物种同源物等。MAX基因可以通过例如 Wagner，A.等，1992年、Proceedings of the National Academic Sciences U.S.A.、第89卷、p.3111-3115中记载的方法获得。MAX基因的表达 变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“MLL4基因”或“MLL4”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号6)表示的 Trithorax Homolog 2基因(DNA)、其同源物、变异体及衍生物等的 基因(DNA)。具体而言，包括序列号6所述的MLL4基因(Ensembl Gene ID，ENSG 00000105663)或其他生物种同源物等。MLL4基因可以通 过例如Nagase，T.等，1997年、DNA Research、第4卷、p.141-150 中记载的方法获得。MLL4基因的表达变化可以成为肾癌转移的指标 尚属未知。
本说明书中使用的“CACNB2基因”或“CACNB2”的术语，在 没有被序列号定义的情况下，包括编码特定碱基序列(序列号7)表 示的Dihydropyridine-Sensitive L-Type，Calcium Channel Beta-2 Subunit基因(DNA)、其同源物、变异体及衍生物等的基因(DNA)。 具体而言，包括序列号7所述的CACNB2基因(Ensembl Gene ID，ENSG 00000165995)或其他生物种同源物等。CACNB2基因可以通过例如 Rosenfeld，M.等，1993年、Annals of Neurology.、第33卷、p.113-120 中记载的方法获得。CACNB2基因的表达变化可以成为肾癌转移的指 标尚属未知。
本说明书中使用的“ZMYND11基因”或“ZMYND11”的术语， 在没有被序列号定义的情况下，包括编码特定碱基序列(序列号8) 表示的Adenovirus 5 E1A-Binding Protein基因(DNA)、其同源物、 变异体及衍生物等的基因(DNA)。具体而言，包括序列号8所述的 ZMYND11基因(Ensembl Gene ID，ENSG00000015171)或其他生物 种同源物等。ZMYND 11基因可以通过例如Hateboer，G.等，1995年、 EMBO Journal、第14卷、p.3159-3169中记载的方法获得。ZMYND11 基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“BAT2基因”或“BAT2”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号9)表示的 Adenovirus 5 E1A-Binding Protein基因(DNA)、其同源物、变异体 及衍生物等的基因(DNA)。具体而言，包括序列号9所述的BAT2 基因(Ensembl Gene ID，ENSG00000111960)或其他生物种同源物等。 BAT2基因可以通过例如Banerji，J.等，1990年、Proceedings of the National Academic Sciences U.S.A.、第87卷、p.2374-2378中记载的 方法获得。BAT2基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“NRBP基因”或“NRBP”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号10)表示的 Nuclear Receptor Binding Protein基因(DNA)、其同源物、变异体及 衍生物等的基因(DNA)。具体而言，包括序列号10所述的NRBP基 因(Ensembl Gene ID，ENSG00000115216)或其他生物种同源物等。 NRBP基因可以通过例如Hooper，J.D..等，2000年、Genomics、第66 卷、p.113-118中记载的方法获得。NRBP基因的表达变化可以成为 肾癌转移的指标尚属未知。
本说明书中使用的“MCM3AP基因”或“MCM3AP”的术语，在 没有被序列号定义的情况下，包括编码特定碱基序列(序列号11)表 示的80KDa MCM3-Associated Protein基因(DNA)、其同源物、变 异体及衍生物等的基因(DNA)。具体而言，包括序列号11所述的 MCM3AP基因(Ensembl Gene ID，ENSG00000160294)或其他生物 种同源物等。MCM3AP基因可以通过例如Takei，Y.等，1998年、Journal of Biological Chemistry、第273卷、p.22177-22180中记载的方法获得。 虽在特表2005-520536中推定MCM3AP基因的表达变化可成为肾癌 的指标，但没有被证实。
本说明书中使用的“COL4A1基因”或“COL4A1”的术语，在没 有被序列号定义的情况下，包括编码特定碱基序列(序列号12)表示 的Collagen Alpha 1(IV)Chain基因(DNA)、其同源物、变异体及 衍生物等的基因(DNA)。具体而言，包括序列号12所述的COL4A1 基因(Ensembl Gene ID，ENSG00000139825)或其他生物种同源物等。 COL4A1基因可以通过例如Solomon，E.等，1985年Proceedings of the National Academic Sciences U.S.A.、第82卷、p.3330-3334中记载的 方法获得。COL4A1基因的表达变化可以成为肾癌转移的指标尚属未 知。
本说明书中使用的“MKNK1基因”或“MKNK1”的术语，在没 有被序列号定义的情况下，包括编码特定碱基序列(序列号13)表示 的MAP Kinase-Interacting Serine/Threonine Kinase 1基因(DNA)、 其同源物、变异体及衍生物等的基因(DNA)。具体而言，包括序列 号13所述的MKNK1基因(Ensembl Gene ID，.ENSG00000079277)或 其他生物种同源物等。MKNK1基因可以通过例如Fukunaga，R.等， 1997年、EMBO Journal、第16卷、P.1921-1933中记载的方法获得。 MKNK1基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“BBC3基因”或“BBC3”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号14)表示的 BCL2 Binding Component 3基因(DNA)、其同源物、变异体及衍生 物等的基因(DNA)。具体而言，包括序列号14所述的BBC3基因 (Ensembl Gene ID，ENSG00000105327)或其他生物种同源物等。 BBC3基因可以通过例如Yu，J.等，2001年、Molecular Cell、第7卷、 p.673-682中记载的方法获得。BBC3基因的表达变化可以成为肾癌转 移的指标尚属未知。
本说明书中使用的“FLJ10359基因”或“FLJ10359”的术语，在 没有被序列号定义的情况下，包括编码特定碱基序列(序列号15)表 示的Protein BAP28基因(DNA)、其同源物、变异体及衍生物等的基 因(DNA)。具体而言，包括序列号15所述的FLJ10359基因(Ensembl Gene ID，ENSG00000119285)或其他生物种同源物等。
本说明书中使用的“DPT基因”或“DPT”的术语，在没有被序 列号定义的情况下，包括编码碱基序列(序列号16)表示的 Dermatopontin基因(DNA)、其同源物、变异体及衍生物等的基因 (DNA)。具体而言，包括序列号16所述的DPT基因(Ensembl Gene ID，ENSG 00000143196)或其他生物种同源物等。DPT基因可以通过 例如Superti-Fruga，A.等，1993年、Genomics、第17卷、p.463-467 中记载的方法获得。DPT基因的表达变化可以成为肾癌转移的指标尚 属未知。
本说明书中使用的“C10orf76基因”或“C10orf76”的术语，在 没有被序列号定义的情况下，包括编码特定碱基序列(序列号17)表 示的基因(DNA)、其同源物、变异体及衍生物等的基因(DNA)。 具体而言，包括序列号17所述的C10orf76基因(Ensembl Gene ID， ENSG00000120029)或其他生物种同源物等。
本说明书中使用的“DIA1基因”或“DIA1”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号18)表示的 NADH-Cytochrome B5 Reductase基因(DNA)、其同源物、变异体 及衍生物等的基因(DNA)。具体而言，包括序列号18所述的DIA1 基因(Ensembl Gene ID，ENSG00000100243)或其他生物种同源物等。 DIA1基因可以通过例如Du，M.等，1997年、Biochemical Biophysical Research Communication、第235卷、p.779-783中记载的方法获得。 DIA1基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“PBK基因”或“PBK”的术语，在没有被序 列号定义的情况下，包括编码特定碱基序列(序列号19)表示的T- LAK Cell-Originated Protein Kinase基因(DNA)、其同源物、变异 体及衍生物等的基因(DNA)。具体而言，包括序列号19所述的PBK 基因(Ensembl Gene ID，ENSG00000168078)或其他生物种同源物等。 PBK基因可以通过例如Gaudet，S.等，2000年、Proceedings of the National Academic Sciences U.S.A.、第97卷、p.5167-5172中记载的 方法获得。PBK基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“PRKD2基因”或“PRKD2”的术语，在没有 被序列号定义的情况下，包括编码特定碱基序列(序列号20)表示的 Protein Kinase C，D2 Type基因(DNA)、其同源物、变异体及衍生 物等的基因(DNA)。具体而言，包括序列号20所述的PRKD2基因 (Ensembl Gene ID，ENSG00000105287)或其他生物种同源物等。 PRKD2基因可以通过例如Sturany，S.等，2001年、Journal of Biological Chemistry、第276卷、p.3310-3318中记载的方法获得。PRKD2基因 的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“KRT19基因”或“KRT19”的术语，在没有 被序列号定义的情况下，包括编码特定碱基序列(序列号21)表示的 Keratin，Type I Cytoskeletal 19基因(DNA)、其同源物、变异体及 衍生物等的基因(DNA)。具体而言，包括序列号21所述的KRT19 基因(Ensembl Gene ID，ENSG00000171345)或其他生物种同源物等。 KRT19基因可以通过例如Bader，B.等，1986年、EMBO Journal、第5 卷、p.1865-1875中记载的方法获得。虽然特表2005-507997中推定 KRT19基因的表达变化可成为肾癌的指标，但未被证实。
本说明书中使用的“FLJ23436基因”或“FLJ23436”的术语，在 没有被序列号定义的情况下，包括编码特定碱基序列(序列号22)表 示的基因(DNA)、其同源物、变异体及衍生物等的基因(DNA)。 具体而言，包括序列号22所述的FLJ23436基因(Ensembl Gene ID， ENSG00000169957)或其他生物种同源物等。FLJ23436基因可以通过 例如Beausoleil，S.A.等，2004年、Proceedings of the National Academic Sciences U.S.A.、第101卷、p.12130-12135中记载的方法获得。 FLJ23436基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“NPHS2基因”或“NPHS2”的术语，在没有 被序列号定义的情况下，包括编码特定碱基序列(序列号23)表示的 Podocin基因(DNA)、其同源物、变异体及衍生物等的基因(DNA)。 具体而言，包括序列号23所述的NPHS2基因(Ensembl Gene ID， ENSG00000116218)或其他生物种同源物等。NPHS2基因可以通过例 如Kestila，M.等，1998年、Molecular Cell、第1卷、p.575-582中记 载的方法获得。NPHS2基因的表达变化可以成为肾癌转移的指标尚属 未知。
本说明书中使用的“C3orf14基因”或“C3orf14”的术语，在没 有被序列号定义的情况下，包括编码特定碱基序列(序列号24)表示 的HT021基因(DNA)、其同源物、变异体及衍生物等的基因(DNA)。 具体而言，包括序列号24所述的C3orf14基因(Ensembl Gene ID， ENSG00000114405)或其他生物种同源物等。
本说明书中使用的“AGTR2基因”或“AGTR2”的术语，在没有 被序列号定义的情况下，包括编码特定碱基序列(序列号25)表示的 Type-2 Angiotensin II Receptor基因(DNA)、其同源物、变异体及 衍生物等的基因(DNA)。具体而言，包括序列号25所述的AGTR2 基因(Ensembl Gene ID，ENSG00000180772)或其他生物种同源物等。 AGTR2基因可以通过例如Koike，G.等，1994年、Biochemical Biophysical Research Communication、第203卷、p.1842-1850中记载 的方法获得。AGTR2基因的表达变化可以成为肾癌转移的指标尚属未 知。
本说明书中使用的“HTR1F基因”或“HTR1F”的术语，在没有 被序列号定义的情况下，包括编码特定碱基序列(序列号26)表示的 5-Hydroxytryptamine 1F Receptor基因(DNA)、其同源物、变异体 及衍生物等的基因(DNA)。具体而言，包括序列号26所述的HTR1F 基因(Ensembl Gene ID，ENSG00000179097)或其他生物种同源物等。 HTR1F基因可以通过例如Lovenberg，T.W.等，1993年、Proceedings of the National Academic Sciences U.S.A.、第90卷、p.2184-2188中记载 的方法获得。HTR1F基因的表达变化可以成为肾癌转移的指标尚属未 知。
本说明书中使用的“KIF3B基因”或“KIF3B”的术语，在没有 被序列号定义的情况下，包括编码特定碱基序列(序列号27)表示的 Kinesin-Like Protein KIF3B基因(DNA)、其同源物、变异体及衍 生物等的基因(DNA)。具体而言，包括序列号27所述的KIF3B基因 (Ensembl Gene ID，ENSG00000101350)或其他生物种同源物等。 KIF3B基因可以通过例如Nagase，T.等，1997年、DNA Research、第4 卷、p.141-150中记载的方法获得。KIF3B基因的表达变化可以成为 肾癌转移的指标尚属未知。
本说明书中使用的“DCN基因”或“DCN”的术语，在没有被序 列号定义的情况下，包括编码特定碱基序列(序列号28)表示的Decorin 基因(DNA)、其同源物、变异体及衍生物等的基因(DNA)。具体 而言，包括序列号28所述的DCN基因(Ensembl Gene ID，ENSG 00000011465)或其他生物种同源物等。DCN基因可以通过例如 Danielson，K.G.等，1993年、Genomics、第15卷、p.146-160中记载 的方法获得。DCN基因的表达变化可以成为肾癌转移的指标尚属未 知。
本说明书中使用的“STK22C基因”或“STK22C”的术语，在没 有被序列号定义的情况下，包括编码特定碱基序列(序列号29)表示 的Testis-Specific Serine/Threonine Kinase 22C基因(DNA)、其同 源物、变异体及衍生物等的基因(DNA)。具体而言，包括序列号29 所述的STK22C基因(Ensembl Gene ID，ENSG00000162526)或其他 生物种同源物等。STK22C基因可以通过例如Visconti，P.E.等，2001 年、Genomics、第77卷、p.163-170中记载的方法获得。STK22C基 因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“DKFZp566C0424基因”或“DKFZp566C0424” 的术语，在没有被序列号定义的情况下，包括编码特定碱基序列(序 列号30)表示的Putative MAPK Activating Protein PM20基因(DNA)、 其同源物、变异体及衍生物等的基因(DNA)。具体而言，包括序列 号30所述的DKFZp566C0424基因(ENSG00000055070)或其他生物 种同源物等。DKFZp566C0424基因可以通过例如Visconti，P.E.等， 2001年、Genomics、第77卷、p.163-170中记载的方法获得。 DKFZp566C0424基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“CNR1基因”或“CNR1”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号31)表示的 Cannabinoid Receptor 1基因(DNA)、其同源物、变异体及衍生物等 的Cannabinoid Receptor 1基因(DNA)。具体而言，包括序列号31所 述的CNR1基因(Ensembl Gene ID，ENSG00000118432)或其他生物 种同源物等。CNR1基因可以通过例如Matsuda，L.A.等，1990年、Nature、 第346卷、p.561-564中记载的方法获得。CNR1基因的表达变化可以 成为肾癌转移的指标尚属未知。
本说明书中使用的“HOMER3基因”或“HOMER3”的术语，在 没有被序列号定义的情况下，包括编码特定碱基序列(序列号32)表 示的HOMER，Neuronal Immediate Early Gene，3基因(DNA)、其同 源物、变异体及衍生物等的基因(DNA)。具体而言，包括序列号32 所述的HOMER3基因(Ensembl Gene ID，ENSG00000051128)或其 他生物种同源物等。HOMER3基因可以通过例如Xiao，B.等，2001年、 Neuron、第21卷、p.707-716中记载的方法获得。HOMER3基因的表 达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“GPR2基因”或“GPR2”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号33)表示的C -C Chemokine Receptor Type 10基因(DNA)、其同源物、变异体及 衍生物等的基因(DNA)。具体而言，包括序列号33所述的GPR2基 因(Ensembl Gene ID，ENSG00000177032)或其他生物种同源物等。 GPR2基因可以通过例如Marchese，A.等，1994年、Genomics、第23 卷、p.609-618中记载的方法获得。GPR2基因的表达变化可以成为肾 癌转移的指标尚属未知。
本说明书中使用的“FLJ12442基因”或“FLJ12442”的术语，在 没有被序列号定义的情况下，包括编码特定碱基序列(序列号34)表 示的基因(DNA)、其同源物、变异体及衍生物等的基因(DNA)。 具体而言，包括序列号34所述的FLJ12442基因(Ensembl Gene ID， ENSG00000168268)或其他生物种同源物等。FLJ12442基因可以通过 例如Ota，T.等，2004年、Nature Genetics、第36卷、p.40-45中记载 的方法获得。FLJ12442基因的表达变化可以成为肾癌转移的指标尚属 未知。
本说明书中使用的“XLKD1基因”或“XLKD1”的术语，在没 有被序列号定义的情况下，包括编码特定碱基序列(序列号35)表示 的Extracellular Link Domain Containing 1基因(DNA)、其同源物、 变异体及衍生物等的基因(DNA)。具体而言，包括序列号35所述的 XLKD1基因(Ensembl Gene ID，ENSG00000133800)或其他生物种 同源物等。XLKD1基因可以通过例如Banerji，S.等，1999年、Journal of Cellular Biology、第144卷、p.1789-801中记载的方法获得。XLKD1 基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“CASKIN2基因”或“CASKIN2”的术语，在 没有被序列号定义的情况下，包括编码特定碱基序列(序列号36)表 示的CASK-Interacting Protein 2基因(DNA)、其同源物、变异体及 衍生物等的基因(DNA)。具体而言，包括序列号36所述的CASKIN2 基因(Ensembl Gene ID，ENSG00000177303)或其他生物种同源物等。 CASKIN2基因可以通过例如Strausberg，R.L.等，2002年、Proceedings ofthe National Academic Sciences U.S.A.、第99卷、p.16899-16903中 记载的方法获得。CASKIN2基因的表达变化可以成为肾癌转移的指标 尚属未知。
本说明书中使用的“COL5A2基因”或“COL5A2”的术语，在没 有被序列号定义的情况下，包括编码特定碱基序列(序列号37)表示 的Collagen Alpha 2(V)Chain基因(DNA)、其同源物、变异体及 衍生物等的基因(DNA)。具体而言，包括序列号37所述的COL5A2 基因(Ensembl Gene ID，ENSG00000179877)或其他生物种同源物等。 COL5A2基因可以通过例如Burgeson，R.E.等，2002年、Proceedings of the National Academic Sciences U.S.A.、第73卷、p.2579-2583中记载 的方法获得。COL5A2基因的表达变化可以成为肾癌转移的指标尚属 未知。
本说明书中使用的“BRD3基因”或“BRD3”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号38)表示的 Bromodomain-Containing Protein 3基因(DNA)、其同源物、变异 体及衍生物等的基因(DNA)。具体而言，包括序列号38所述的BRD3 基因(Ensembl Gene ID，ENSG00000169925)或其他生物种同源物等。 BRD3基因可以通过例如Nomura，N.L.等，1994年、DNA Research、 第1卷、p.223-229中记载的方法获得。BRD3基因的表达变化可以成 为肾癌转移的指标尚属未知。
本说明书中使用的“ATP6V0A4基因”或“ATP6V0A4”的术语， 在没有被序列号定义的情况下，包括编码特定碱基序列(序列号39) 表示的ATPase，H+Transporting，Lysosomal V0 Subunit A ISOFORM 4基因(DNA)、其同源物、变异体及衍生物等的基因(DNA)。具 体而言，包括序列号39所述的ATP6V0A4基因(Ensembl Gene ID， ENSG00000105929)或其他生物种同源物等。ATP6V0A4基因可以通 过例如Smith，A.N.等，2000年、Nature Genetics、第26卷、p.71-75 中记载的方法获得。ATP6V0A4基因的表达变化可以成为肾癌转移的 指标尚属未知。
本说明书中使用的“PRODH2基因”或“PRODH2”的术语，在 没有被序列号定义的情况下，包括编码特定碱基序列(序列号40)表 示的Nephrin基因(DNA)、其同源物、变异体及衍生物等的基因 (DNA)。具体而言，包括序列号40所述的PRODH2基因(Ensembl Gene ID，ENSG00000161270)或其他生物种同源物等。PRODH2基 因可以通过例如Chakravarti，A.等，2002年、Proceedings of the National Academic Sciences U.S.A.、第99卷、p.4755-4756中记载的方法获得。 PRODH2基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“EPHB2基因”或“EPHB2”的术语，在没有 被序列号定义的情况下，包括编码特定碱基序列(序列号41)表示的 Ephrin Type-B Receptor 2基因(DNA)、其同源物、变异体及衍生 物等的基因(DNA)。具体而言，包括序列号41所述的EPHB2基因 (Ensembl Gene ID，ENSG00000133216)或其他生物种同源物等。 EPHB2基因可以通过例如Chan，J.等，1991年、Oncogene、第6卷、 p.1057-1061中记载的方法获得。EPHB2基因的表达变化可以成为肾 癌转移的指标尚属未知。
本说明书中使用的“LYAR基因”或“LYAR”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号42)表示的 Hypothetical Protein FLJ20425基因(DNA)、其同源物、变异体及衍 生物等的基因(DNA)。具体而言，包括序列号42所述的LYAR基因 (Ensembl Gene ID，ENSG00000145220)或其他生物种同源物等。 LYAR基因可以通过例如Su，L.等，1993年、Genes Development、第7 卷、p.735-748中记载的方法获得。LYAR基因的表达变化可以成为 肾癌转移的指标尚属未知。
本说明书中使用的“COX6B基因”或“COX6B”的术语，在没 有被序列号定义的情况下，包括编码特定碱基序列(序列号43)表示 的Cytochrome C Oxidase Polypeptide VIB基因(DNA)、其同源物、 变异体及衍生物等的基因(DNA)。具体而言，包括序列号43所述的 COX6B基因(Ensembl Gene ID，ENSG00000126267)或其他生物种 同源物等。COX6B基因可以通过例如Taanman，J-W.等，1989年、 Nucleic Acids Research、第17卷、p.1766中记载的方法获得。COX6B 基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“PRH1基因”或“PRH1”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号44)表示的 Salivary Acidic Proline-Rich Phosphoprotein 1/2基因(DNA)、其 同源物、变异体及衍生物等的基因(DNA)。具体而言，包括序列号 44所述的PRH1基因(Ensembl Gene ID，ENSG00000176621)或其他 生物种同源物等。PRH1基因可以通过例如Oppenheim，F.G.等，1971 年、Biochemistry、第10卷、p.4233-4238中记载的方法获得。PRH1 基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“LAPTM5基因”或“LAPTM5”的术语，在 没有被序列号定义的情况下，包括编码特定碱基序列(序列号45)表 示的Lysosomal-Associated Multitransmembrane Protein基因(DNA)、 其同源物、变异体及衍生物等的基因(DNA)。具体而言，包括序列 号45所述的LAPTM5基因(Ensembl Gene ID，ENSG00000162511)或 其他生物种同源物等。LAPTM5基因可以通过例如Adra，C.N.等，1996 年、Genomics、第35卷、p.328-337中记载的方法获得。LAPTM5基 因的表达变化可以成为肾癌转移的指标尚属未知，但已经推定可以成 为肾癌的标记物(国际公开WO2005/24603)。
本说明书中使用的“RPS6KA4基因”或“RPS6KA4”的术语，在 没有被序列号定义的情况下，包括编码特定碱基序列(序列号46)表 示的Ribosomal Protein S6 Kinase，90KDA，Polypeptide 4基因(DNA)、 其同源物、变异体及衍生物等的基因(DNA)。具体而言，包括序列 号46所述的RPS6KA4基因(Ensembl Gene ID，ENSG00000162302) 或其他生物种同源物等。RPS6KA4基因可以通过例如Pierrat，B.等， 1998年、Journal of Biological Chemistry、第273卷、p.29661-29671 中记载的方法获得。RPS6KA4基因的表达变化可以成为肾癌转移的指 标尚属未知。
本说明书中使用的“GCC2基因”或“GCC2”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号47)表示的GRIP and Coiled-Coil Domain Containing 2基因(DNA)、其同源物、变异 体及衍生物等的基因(DNA)。具体而言，包括序列号47所述的GCC2 基因(Ensembl Gene ID，ENSG00000144055)或其他生物种同源物等。 GCC2基因可以通过例如Eichmuller，S.等，2001年、Proceedings of the National Academic Sciences U.S.A.、第98卷、p.629-634中记载的方 法获得。GCC2基因的表达变化可以成为肾癌转移的指标尚属未知。
本说明书中使用的“FGF2基因”或“FGF2”的术语，在没有被 序列号定义的情况下，包括编码特定碱基序列(序列号48)表示的 Heparin-Binding Growth Factor 2基因(DNA)、其同源物、变异体 及衍生物等的基因(DNA)。具体而言，包括序列号48所述的FGF2 基因(Ensembl Gene ID，ENSG00000138685)或其他生物种同源物等。 FGF2基因可以通过例如Abraham，J.等，1986年、Science、第233卷、 p.545-548中记载的方法获得。如Miyake，H.等，1996年、Cancer Research、第56卷、p.2440-2445所示，已公知FGF2基因的表达变化 可以成为肾癌转移的指标。
本说明书中使用的“MMP14基因”或“MMP14”的术语，在没 有被序列号定义的情况下，包括编码特定碱基序列(序列号49)表示 的Matrix Metalloproteinase-14基因(DNA)、其同源物、变异体及 衍生物等的基因(DNA)。具体而言，包括序列号49所述的MMP14 基因(Ensembl Gene ID，ENSG00000157227)或其他生物种同源物等。 MMP14基因可以通过例如Sato，H.等，1994年、Nature、第370卷、p.61 -65中记载的方法获得。如Kitagawa，Y.等，1999年、Journal of Urology、 第162卷、p.905-909等所示，已公知MMP14基因的表达变化可以成 为肾癌转移的指标。
本说明书中使用的“ERBB2基因”或“ERBB2”的术语，在没有 被序列号定义的情况下，包括编码特定碱基序列(序列号50)表示的 Receptor Protein-Tyrosine Kinase ERBB-2基因(DNA)、其同源物、 变异体及衍生物等的基因(DNA)。具体而言，包括序列号50所述的 ERBB2基因(Ensembl Gene ID，ENSG00000141736)或其他生物种 同源物等。ERBB2基因可以通过例如Yang-Feng，T.L.等，1985年、 Citogenetic Cell Genetics、第40卷、p.784中记载的方法获得。如Freeman， M.R.等，1989年、Cancer Research、第49卷、p.6221-6225所示，已 公知ERBB2基因的表达变化可以成为肾癌转移的指标。
对于本说明书中记载的其它基因或多肽，在下述详细说明中适当 地说明。
本发明提供一种对诊断、检测、确定或预测肾癌的存在或肾癌转 移、及对治疗肾癌有用的疾病确定用组合物、及使用该组合物用于诊 断、检测、确定或预测肾癌及肾癌转移的方法，因此，本发明通过提 供一种特异性地且高预测率的、及迅速且简便地、对肾癌的存在或肾 癌转移进行检测、确定或预测方法，具有显著的作用效果。
另外，本发明的肾癌标记物中的一部分也可能出现在肾癌患者的 血液等生物试样中，但在健康人中几乎或完全没有，因此，也具有下 述作用效果，即，只需以上述标记物的存在或量为指标，即可在例如 血液中容易地检测肾癌。
本发明通过将本发明的检测肾癌的探针和检测肾癌转移的探针 组合，能够进行有利于肾癌患者的预后管理的诊断。
附图说明
[图1]表示手术时未诊断出转移至肾脏以外器官的患者组(M＝0) 和诊断出转移的患者组(M＝1)分别采用Kaplan-Meier法绘制的生 存曲线。纵轴表示生存率，横轴表示手术后的年数(年)。5年生存 率在M＝0时为96％、M＝1时为13％。
[图2]表示组合对应于表1所述基因的序列号1～19、48的多核苷酸 用作DNA芯片时预后良好的患者预测率、及组合序列号20～47、49、 50的多核苷酸用作DNA芯片时的预后不良的患者预测率。纵轴表示能 预测预后良好的患者/预后不良的患者的概率(预测率)、横轴表示 预测预后良好的患者/预后不良的患者所需的基因的总数。实线表示 预后良好的患者的预测概率，虚线表示预后不良的患者的预测概率。
具体实施方式
以下更加具体地说明本发明。
1.肾癌相关标记物
1.1.肾癌相关靶核酸
作为在使用本发明的组合物、试剂盒或DNA芯片检测、确定或预 测肾癌的存在及转移、预测肾癌患者预后、及确定肾癌转移细胞的存 在或不存在时使用的肾癌转移关联标记物的靶核酸，包括例如含有序 列号1～50表示的碱基序列的人基因(即、分别为PABPN1、PINK1、 TFF2、EIF3S9、MAX、MLL4、CACNB2、ZMYND11、BAT2、NRBP、 MCM3AP、COL4A1、MKNK1、BBC3、FLJ10359、DPT、C10orf76、 DIA1、PBK、PRKD2、KRT19、FLJ23436、NPHS2、C3orf14、AGTR2、 HTR1F、KIF3B、DCN、STK22C、DKFZp566C0424、CNR1、HOMER3、 GPR2、FLJ12442、XLKD1，CASKIN2、COL5A2、BRD3、ATP6V0A4、 PRODH2、EPHB2、LYAR、COX6B、PRH1、LAPTM5、RPS6KA4、 GCC2、FGF2、MMP14及ERBB2)、它们的同源物、它们的转录产物 或cDNA、或者它们的变异体或衍生物。此处，基因、同源物、转录 产物、cDNA、变异体及衍生物如上述定义所示。理想的靶核酸为含 有序列号1～50表示的碱基序列的人基因、它们的转录产物或cDNA， 较理想为该转录产物或cDNA。
本发明中，成为肾癌患者预后预测的靶标及/或肾癌转移预测的 靶标的上述基因，均为与来自预后良好的患者的肾癌组织相比在来自 预后不良的患者的肾癌组织中该基因的表达水平显著变化(即、增加 或降低)的基因。表1给出各基因的Ensemble Gene ID及GenBank登录 号。所示的基因由识别来自预后良好的患者的肾癌组织的基因、识别 来自预后不良的患者的肾癌组织的基因构成。
[表1]
序 列 号 Ensemble Gene ID GenBank 登录号 基因名 序 列 号 Ensemble Gene ID GenBank 登录号 基因名 1 ENSG0000010 0836 NM_004643 PABPN1 26 ENSG00000179097 NM_000866 HTR1F 2 ENSG0000018 0056 NM_032409 PINK1 27 ENSG00000101350 NM_004798 KIF3B 3 ENSG0000016 0181 NM_005423 TFF2 28 ENSG00000011465 NM_133506 DCN 4 ENSG0000010 6263 NM_003751 EIF3S9 29 ENSG00000162526 NM_052841 STK22C 5 ENSG0000012 5952 NM_002382 MAX 30 ENSG00000055070 BX640985 DKFZp566C04 24 6 ENSG0000010 5663 NM_014727 MLL4 31 ENSG00000118432 NM_016083 CNR1 7 ENSG0000016 5995 NM_000724 CACNB2 32 ENSG00000051128 NM_004838 HOMER3 8 ENSG0000001 5171 NM_006624 ZMYND1 1 33 ENSG00000177032 NM_016602 GPR2 9 ENSG0000011 1960 NM_004638 BAT2 34 ENSG00000168268 NM_022908 FLJ12442 10 ENSG0000011 5216 NM_013392 NRBP 35 ENSG00000133800 NM_006691 XLKD1 11 ENSG0000016 0294 NM_003906 MCM3AP 36 ENSG00000177303 NM_020753 CASKIN2 12 ENSG0000013 9825 NM_001845 COL4Al 37 ENSG00000179877 NM_000393 COL5A2 13 ENSG0000007 9277 NM_003684 MKNK1 38 ENSG00000169925 NM_007371 BRD3 14 ENSG0000010 5327 NM_014417 BBC3 39 ENSG00000105929 NM_020632 ATP6V0A4 15 ENSG0000011 9285 NM_018072 FLJ10359 40 ENSG00000161270 NM_021232 PRODH2 16 ENSG0000014 3196 NM_001937 DPT 41 ENSG00000133216 NM_004442 EPHB2 17 ENSG0000012 0029 NM_024541 C10orf76 42 ENSG00000145220 NM_017816 LYAR 18 ENSG0000010 0243 NM_007326 DIA1 43 ENSG00000126267 NM_001863 COX6B 19 ENSG0000016 8078 NM_018492 PBK 44 ENSG00000176621 NM_006250 PRH2 20 ENSG0000010 5287 NM_016457 PRKD2 45 ENSG00000162511 NM_006762 LAPTM5 21 ENSG0000017 1345 NM_002276 KRT19 46 ENSG00000162302 NM_003942 RPS6KA4 22 ENSG0000016 9957 NM_024671 FLJ23436 47 ENSG00000144055 NM_181453， NM_014635 GCC2 23 ENSG0000011 6218 NM_014625 NPHS2 48 ENSG00000138685 NM_002006 FGF2 24 ENSG0000011 4405 NM_020685 C3orf14 49 ENSG00000157227 NM_004995 MMP14 25 ENSG0000018 0772 NM_000686 AGTR2 50 ENSG00000141736 NM_004448 ERBB2
第1靶核酸为，PABPN1基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第2靶核酸为，PINK1基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第3靶核酸为，TFF2基因、其同源物、其转录产物或cDNA、或者 其变异体或衍生物。
第4靶核酸为，EIF3S9基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第5靶核酸为，MAX基因、其同源物、其转录产物或cDNA、或者 其变异体或衍生物。
第6靶核酸为，MLL4基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第7靶核酸为，CACNB2基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第8靶核酸为，ZMYND11基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第9靶核酸为，BAT2基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第10靶核酸为，NRBP基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第11靶核酸为，MCM3AP基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第12靶核酸为，COL4A1基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第13靶核酸为，MKNK1基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第14靶核酸为，BBC3基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第15靶核酸为，FLJ10359基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第16靶核酸为，DPT基因、其同源物、其转录产物或cDNA、或者 其变异体或衍生物。
第17靶核酸为，C10orf76基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第18靶核酸为，DIA1基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第19靶核酸为，PBK基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第20靶核酸为，PRKD2基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第21靶核酸为，KRT19基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第22靶核酸为，FLJ23436基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第23靶核酸为，NPHS2基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第24靶核酸为，C3orf14基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第25靶核酸为，AGTR2基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第26靶核酸为，HTR1F基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第27靶核酸为，KIF3B基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第28靶核酸为，DCN基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第29靶核酸为，STK22C基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第30靶核酸为，DKFZp566C0424基因、其同源物、其转录产物或 cDNA、或者其变异体或衍生物。
第31靶核酸为，CNR1基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第32靶核酸为，HOMER3基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第33靶核酸为，GPR2基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第34靶核酸为，FLJ12442基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第35靶核酸为，XLKD1基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第36靶核酸为，CASKIN2基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第37靶核酸为，COL5A2基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第38靶核酸为，BRD3基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第39靶核酸为，ATP6V0A4基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第40靶核酸为，PRODH2基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第41靶核酸为，EPHB2基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第42靶核酸为，LYAR基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第43靶核酸为，COX6B基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第44靶核酸为，PRH1基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第45靶核酸为，LAPTM5基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第46靶核酸为，RPS6KA4基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第47靶核酸为，GCC2基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第48靶核酸为，FGF2基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第49靶核酸为，MMP14基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第50靶核酸为，ERBB2基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
1.2肾癌相关靶多肽(1)
作为在使用本发明的组合物或试剂盒检测、确定或预测肾癌的存 在及转移、预测肾癌患者预后、及确定肾癌转移细胞的存在或不存在 时使用的肾癌关联标记物的靶多肽，包括由下述基因编码的多肽，例 如，含有序列号101～150表示的氨基酸序列的人多肽、其同源物、或 者其变异体或衍生物，所述基因为PABPN1、PINK1、TFF2、EIF3S9、 MAX、MLL4、CACNB2、ZMYND11、BAT2、NRBP、MCM3AP、 COL4A1、MKNK1、BBC3、FLJ10359、DPT、C10orf76、DIA1、PBK、 PRKD2、KRT19、FLJ23436、NPHS2、C3orf14、AGTR2、HTR1F、 KIF3B、DCN、STK22C、DKFZp566C0424、CNR1、HOMER3、GPR2、 FLJ12442、XLKD1、CASKIN2、COL5A2、BRD3、ATP6V0A4、PRODH2、 EPHB2、LYAR、COX6B、PRH1、LAPTM5、RPS6KA4、GCC2、FGF2、 MMP14及ERBB2基因。此处，多肽、同源物、变异体及衍生物如上 述定义所示。理想的靶多肽为含有序列号101～110、112～120、122～ 147表示的氨基酸序列的人多肽。
本发明中成为肾癌转移预测及/或肾癌患者预后预测的靶标的 上述多肽的特征在于，与对应的基因及其转录产物的表达量相同，都 为与来自预后良好的肾癌患者的肾癌组织相比在来自预后不良的肾 癌患者的肾癌组织中其表达量显著变化(即，增加或降低)的多肽， 或血液中该多肽的水平与预后良好的肾癌患者相比在预后不良的肾 癌患者中显著变化(即，增加或降低)。
1.3肾癌相关靶多肽(2)
作为在使用本发明的组合物或试剂盒体外检测肾癌时使用的肾 癌标记物的其它肾癌相关靶多肽，是含有序列号151～197、优选序列 号151、153、155～160、序列号161～190表示的氨基酸序列的多肽、 其变异体或其片段。
本发明的序列号151～160、191、序列号161～190、192～197的 多肽与其基因名及蛋白质序号(GenBank登录名及登录号)、及其特 性一起分别示于下述表2、表3。上述多肽在肾癌患者血浆中被特异性 检测出，在健康人的血浆中未被检测出、或未达到能够检测的水平。
[表2]
序列号 基因名 蛋白质序号 特性 151 AAK2 P54646 AMP激酶2 152 SLK4 Q8IW52 SLIT及NTRK样蛋白4前体 153 SP4L Q8TC36 精子相关抗原4样蛋白质(睾丸及精子形成 相关基因4蛋白质) 154 C5P1 Q96SZ6 CDK5调节亚单位相关蛋白1(CDK5激活结 合蛋白质C42)(CGI-05) 155 SI8A Q92185 α-N-乙酰-神经氨酸苷α-2，8-唾液 酸转移酶(EC 2.4.99.8)(神经节苷脂GD3 合酶) 156 KAP2 P13861 cAMP依赖性蛋白激酶II型-α调节链 157 F262 060825 6-磷酸果糖-2-激酶/果糖-2，6-二磷 酸酶2(6PF-2-K/Fru-2，6-P2ASE心 脏型同工酶)(PFK-2/FBPase-2)[6 -磷酸果糖-2-激酶〔EC 2.7.1.105)； 含有果糖-2，6-二磷酸酶(EC3.1.3.46)] 158 TCPH Q99832 T-复合蛋白1，eta亚单位(TCP-1-eta) (CCT-eta)(HIV-1Nef相互作用蛋白 质) 159 GB11 P29992 鸟嘌呤核苷酸结合蛋白G(y)，α亚单位(α -11) 160 CT67 Q9H4Z3 蛋白C20orf67 191 CEGT Q16739 神经酰胺葡糖基转移酶(EC 2.4.1.80)(葡 糖神经酰胺合成酶)(GCS)(UDP-葡 萄糖)
[表3]
序列号 基因名 蛋白质序号 特性 161 AMIIR2 Q16671 Anti-muellerian激素II型受体前体(EC 2.7.1.37)(AMH II型受体)(MIS II型受体)(MISRII)(MRII) 162 APOL3 O95236 载脂蛋白L3(载脂蛋白L-III)(ApoL-III)(TNF -诱导性蛋白质CG12-1) 163 DEDD2 Q8WXF8 DNA结合的含有死亡效应结构域的蛋白2(含DED的蛋 白质FLAME-3) 164 HEXB P07686 β-氨基己糖苷酶β链前体(EC 3.2.1.52)(N-乙酰-β- 氨基葡萄糖苷酶) 165 HNRPK P61978 异质性胞核核糖核蛋白(hnRNP K) 166 KPNA1 P52294 输入蛋白(Importin)α-1亚单位(核周蛋白 (karyopherin)α-1亚单位)(SRP1-β)(RAG组蛋 白2)，(核蛋白相互作用蛋白-1)(NPI-1) 167 LASP1 Q14847 LIM及SH3结构域蛋白1(LASP-1)(MLN 50) 168 LIAS O43766 硫辛酸合成酶，线粒体前体(mitochondrial precursor) (Lip-syn)(硫辛酸合成酶)(HUSSY-01) 169 MAGEC3 Q8TD91 黑色素瘤相关抗原C3(MAGE-C3抗原) 170 NFATC4 Q14934 活化T细胞的核因子，细胞质4(T细胞转录因子 NFAT3)(NF-ATc4)(NF-AT3) 171 OLFM3 Q96PB7 Noelin 3前体(嗅介蛋白3)(optimedin)(UNQ1924 /PRO4399) 172 POLR3F Q9H1D9 DNA依赖性RNA聚合酶III 39kDa多肽(EC 2.7.7.6) 173 PPP3CB NP 066955 丝氨酸/苏氨酸蛋白磷酸酶2B催化剂亚单位，β异型 (EC 3.1.3.16) 174 SF1 Q15637 剪接因子1(锌指蛋白162)(转录因子ZFM1) 175 SLC24A2 Q9UI40 钠/钾/钙交换体2前体(Na(+)/K(+)/Ca(2 +)-交换蛋白2) 176 SLC26A4 O43511 潘蛋白(Pendrin)(钠非依赖性氯/碘转运蛋白) 177 SLCO1A2 P46721 溶质运载有机阴离子转运蛋白家族成员1A2 178 TPM2 P07951 原肌球蛋白β链(原肌球蛋白2)(β-原肌球蛋白) 179 UCHL5 Q9Y5K5 泛素羧基末端水解酶同工酶L5(EC 3.4.19.12)(UCH -L5) 180 UGT8 Q16880 2-羟酰基鞘氨醇1-β-半乳糖基转移酶前体(EC 2.4.1.45)(UDP-半乳糖神经酰胺转移酶) 181 ZNF140 P52738 锌指蛋白140 182 ZNF274 Q96GC6 锌指蛋白274(锌指蛋白SP2114)(锌指蛋白HFB101) 183 MID2 Q9UJV3 Midline 2 184 LIPE Q05469 脂酶，激素敏感性 185 HDAC6 Q9UBN7 组蛋白去乙酰化酶6 186 ACO2 Q99798 乌头酸酶(Aconitase)2，线粒体 187 APLP1 P51693 淀粉状蛋白β(A4)前体样蛋白1 188 NUMB P49757 Numb同源物(果蝇)
189 ARHGEF7 Q14155 Rho鸟嘌呤核苷酸交换因子(GEF)7 190 GNAQ P50148 鸟苷酸结合蛋白质(G蛋白质)，q多肽 191 MMP2 P08253 72kDa IV型胶原酶前体(EC 3.4.24.24)(72kDa明胶 酶) 192 TNFRSF7 P26842 肿瘤坏死因子受体超家族成员7前体(CD27L受体) 193 PDE8B O95263 高亲和性cAMP特异性及IBMX非敏感性3’，5’-环磷 酸二酯酶8B 194 FLOT1 O75955 阀蛋白1(Flotillin 1) 195 CD5 P06127 T细胞表面糖蛋白CD5[前体] 196 ECM1 Q16610 细胞外基质蛋白1
在本发明中，用于检测肾癌的上述靶多肽均具有以下特征：该多 肽在肾癌患者的血液等生物试样中的水平与健康人相比，患有肾癌的 受试者中的多肽水平显著或特别高。
2.肾癌诊断用探针
根据本发明，用于检测、确定或预测肾癌的存在及/或转移的探针、 或用于预测受试者术后预后的探针选自下述I组及/或II组：
I组：由以下(a)～(e)构成的多核苷酸，
(a)由序列号1～10、12～20、22～47表示的碱基序列构成的多 核苷酸、其变异体、或其含有15个以上连续碱基的片段，
(b)含有序列号1～10、12～20、22～47表示的碱基序列的多核 苷酸，
(c)由与序列号1～10、12～20、22～47表示的碱基序列互补的 碱基序列构成的多核苷酸、其变异体、或其含有15个以上连续碱基的 片段，
(d)含有与序列号1～10、12～20、22～47表示的碱基序列互补 的碱基序列的多核苷酸，及
(e)与上述(a)～(d)中任一个多核苷酸在严格条件下杂交的 多核苷酸、或其含有15个以上连续碱基的片段，
II组：由(f)～(h)构成的抗体、其片段或者其化学修饰衍生物，
(f)与含有由序列号1～10、12～20、22～47表示的碱基序列编 码的氨基酸序列的多肽、或含有序列号101～110、112～120、122～ 147表示的氨基酸序列的多肽、其变异体、或者其片段中的至少1个特 异性结合的抗体、其片段或者其化学修饰衍生物，
(g)与含有序列号151、153、155～160表示的氨基酸序列的多 肽、其变异体、或者其片段中的至少1个特异性结合的抗体、其片段 或者其化学修饰衍生物，及
(h)与含有序列号161～190表示的氨基酸序列的多肽、其变异 体、或者其片段中的至少1个特异性结合的抗体、其片段或者其化学 修饰衍生物。
上述探针均能与上述1.1至1.3中记载的肾癌相关标记物中的任一 种结合，能够用于检测、确定或预测肾癌的存在或转移。例如，通过 上述I组及II组(f)的各探针，能够检测、确定或预测肾癌的存在或 转移。另外，通过上述II组(g)、(h)的各探针，能够检测、确定 或预测肾癌的存在。
本发明中，核酸探针包括DNA或RNA，另一方面，抗体探针包括 多克隆抗体、单克隆抗体、它们的抗体片段、合成抗体、重组抗体、 多重特异性抗体、单链抗体等。
本次，本发明人等首次发现上述I组及/或II组所示的探针能够用 于肾癌存在及/或转移的检测、确定或预测。
3.用于肾癌诊断及/或肾癌预后预测或转移预测的组合物
3.1核酸组合物
使用本发明的组合物或试剂盒检测、确定或预测肾癌的存在及转 移、预测肾癌患者预后、及确定肾癌转移细胞的存在或不存在时使用 的核酸组合物，含有上述2中的I组中记载的1种或2种以上探针，能 够定性及/或定量地测定作为用于肾癌预后预测或肾癌转移预测的靶 核酸的以下物质的存在、表达量或存在量，所述物质为来自人的 PABPN1、PINK1、TFF2、EIF3S9、MAX、MLL4、CACNB2、ZMYND11、 BAT2、NRBP、MCM3AP、COL4A1、MKNK1、BBC3、FLJ10359、 DPT、C10orf76、DIA1、PBK、PRKD2、KRT19、FLJ23436、NPHS2、 C3orf14、AGTR2、HTR1F、KIF3B、DCN、STK22C、DKFZp566C0424、 CNR1、HOMER3、GPR2、FLJ12442、XLKD1、CASKIN2、COL5A2、 BRD3、ATP6V0A4、PRODH2、EPHB2、LYAR、COX6B、PRH1、 LAPTM5、RPS6KA4、GCC2、FGF2、MMP14及ERBB2基因、其同源 物、其转录产物或cDNA、或其变异体或衍生物。
上述靶核酸在来自预后不良的肾癌患者的肾癌组织中的表达水 平，与来自预后良好的肾癌患者的肾癌组织相比，发生显著变化(即、 增加或降低)。因此，本发明的组合物能够有效地用于测定来自预后 良好的肾癌患者的肾癌组织中和来自预后不良的肾癌患者的肾癌组 织中的靶核酸的表达水平，并对其进行比较。
本发明中能使用的组合物包括选自下述多核苷酸组的1种或多种 多核苷酸的组合，所述多核苷酸组为患有肾癌的患者的生物组织中含 有序列号1～50表示的碱基序列的多核苷酸组及其互补多核苷酸组；在 严格条件下分别与DNA杂交的多核苷酸组及其互补多核苷酸组，所述 DNA由与上述碱基序列互补的碱基序列构成；及含有上述多核苷酸组 的碱基序列中15个以上连续碱基的多核苷酸组。
具体而言，本发明的组合物可以含有以下1种或多种多核苷酸或 其片段。
(1)由序列号1～50表示的碱基序列构成的多核苷酸组、其变异 体、或其含有15个以上连续碱基的片段。
(2)含有序列号1～50表示的碱基序列的多核苷酸组。
(3)由序列号1～10、12～20、22～47表示的碱基序列构成的多 核苷酸组、其变异体、或其含有15个以上连续碱基的片段。
(4)含有序列号1～10、12～20、22～47表示的碱基序列的多核 苷酸组。
(5)由与序列号1～10、12～20、22～47表示的碱基序列互补的 碱基序列构成的多核苷酸组、其变异体、或其含有15个以上连续碱基 的片段。
(6)含有与序列号1～10、12～20、22～47表示的碱基序列互补 的碱基序列的多核苷酸组。
(7)与下述DNA在严格条件下杂交的多核苷酸组、或其含有15 个以上连续碱基的片段，所述DNA由与序列号1～10、12～20、22～ 47表示的各碱基序列互补的碱基序列构成。
(8)与由序列号1～10、12～20、22～47表示的各碱基序列构成 的DNA在严格条件下杂交的多核苷酸组、或其含有15个以上连续碱基 的片段。
(9)由序列号11、21、48～50表示的碱基序列构成的多核苷酸 组、其变异体、或其含有15个以上连续碱基的片段。
(10)含有序列号11、21、48～50表示的碱基序列的多核苷酸组。
(11)由与序列号11、21、48～50表示的碱基序列互补的碱基序 列构成的多核苷酸组、其变异体、或其含有15个以上连续碱基的片段。
(12)含有与序列号11、21、48～50表示的碱基序列互补的碱基 序列的多核苷酸组。
(13)与下述DNA在严格条件下杂交的多核苷酸组、或其含有15 个以上连续碱基的片段，所述DNA由与序列号11、21、48～50表示的 各碱基序列互补的碱基序列构成。
(14)与由序列号11、21、48～50表示的各碱基序列构成的DNA 在严格条件下杂交的多核苷酸组、或其含有15个以上连续碱基的片 段。
上述(1)～(14)的多核苷酸的片段可以含有各多核苷酸的碱 基序列中的例如下述范围的连续碱基数，但并不限定于此，所述范围 包括15～序列的全部碱基数、15～5000个碱基、15～4500个碱基、15～ 4000个碱基、15～3500个碱基、15～3000个碱基、15～2500个碱基、 15～2000个碱基、15～1500个碱基、15～1000个碱基、15～900个碱 基、15～800个碱基、15～700个碱基、15～600个碱基、15～500个碱 基、15～400个碱基、15～300个碱基、15～250个碱基、15～200个碱 基、15～150个碱基、15～140个碱基、15～130个碱基、15～120个碱 基、15～110个碱基、15～100个碱基、15～90个碱基、15～80个碱基、 15～70个碱基、15～60个碱基、15～50个碱基、15～40个碱基、15～ 30个碱基或15～25个碱基；25～序列的全部碱基数、25～1000个碱基、 25～900个碱基、25～800个碱基、25～700个碱基、25～600个碱基、 25～500个碱基、25～400个碱基、25～300个碱基、25～250个碱基、 25～200个碱基、25～150个碱基、25～140个碱基、25～130个碱基、 25～120个碱基、25～110个碱基、25～100个碱基、25～90个碱基、 25～80个碱基、25～70个碱基、25～60个碱基、25～50个碱基或25～ 40个碱基；50～序列的全部碱基数、50～1000个碱基、50～900个碱 基、50～800个碱基、50～700个碱基、50～600个碱基、50～500个碱 基、50～400个碱基、50～300个碱基、50～250个碱基、50～200个碱 基、50～150个碱基、50～140个碱基、50～130个碱基、50～120个碱 基、50～110个碱基、50～100个碱基、50～90个碱基、50～80个碱基、 50～70个碱基或50～60个碱基；60～序列的全部碱基数、60～1000个 碱基、60～900个碱基、60～800个碱基、60～700个碱基、60～600个 碱基、60～500个碱基、60～400个碱基、60～300个碱基、60～250个 碱基、60～200个碱基、60～150个碱基、60～140个碱基、60～130个 碱基、60～120个碱基、60～110个碱基、60～100个碱基、60～90个 碱基、60～80个碱基或60～70个碱基等。
根据本发明的实施方案，含有序列号1～10、12～20、22～47表 示的碱基序列的多核苷酸的片段，优选分别含有序列号51～60、62～ 70、72～97表示的碱基序列或其互补的序列、或者其连续15个碱基以 上的部分序列。
本发明的组合物中例如含有以下多核苷酸。
(1)序列号1～10、12～20、22～47表示的碱基序列或其互补序 列的各序列中，含有15个以上连续碱基的多核苷酸。
(2)序列号1～10、12～20、22～47表示的碱基序列或其互补序 列的各序列中，含有60个以上连续碱基的多核苷酸。
(3)序列号11、21、48～50表示的碱基序列或其互补序列的各 序列中，含有15个以上连续碱基的多核苷酸。
(4)序列号11、21、48～50表示的碱基序列或其互补序列的各 序列中，含有60个以上连续碱基的多核苷酸。
(5)序列号1～10、12～20、22～47表示的碱基序列中，分别含 有序列号51～60、62～70、72～97表示的碱基序列、且含有60个以上 连续碱基的多核苷酸。
(6)与序列号1～10、12～20、22～47表示的碱基序列互补的序 列中，分别含有与序列号51～60、62～70、72～97表示的碱基序列互 补的序列、且含有60个以上连续碱基的多核苷酸。
(7)序列号11、21、48～50表示的碱基序列中，分别含有序列 号61、71、98～100表示的碱基序列、且含有60个以上连续碱基的多 核苷酸。
(8)与序列号11、21、48～50表示的碱基序列互补的序列中， 分别含有与序列号61、71、98～100表示的碱基序列互补的序列、且 含有60个以上连续碱基的多核苷酸。
本发明中使用的上述多核苷酸或其片段均可以为DNA也可以为 RNA。
构成本发明组合物的多核苷酸，可以使用DNA重组技术、PCR法、 采用DNA/RNA自动合成仪的方法等常规技术进行制作。
DNA重组技术及PCR法，例如可以使用Ausubel等，Current Protocols in Molecular Biology，John Willey &Sons，US(1993)； Sambrook等，Molecular Cloning A Laboratory Manual，Cold Spring Harbor Laboratory Press，US(1989)等中记载的技术。
来自人的PABPN1、PINK1、TFF2、EIF3S9、MAX、MLL4、 CACNB2、ZMYND11、BAT2、NRBP、MCM3AP、COL4A1、MKNK1、 BBC3、FLJ10359、DPT、C10orf76、DIA1、PBK、PRKD2、KRT19、 FLJ23436、NPHS2、C3orf14、AGTR2、HTR1F、KIF3B、DCN、STK22C、 DKFZp566C0424、CNR1、HOMER3、GPR2、FLJ12442、XLKD1、 CASKIN2、COL5A2、BRD3、ATP6V0A4、PRODH2、EPHB2、LYAR、 COX6B、PRH1、LAPTM5、RPS6KA4、GCC2、FGF2、MMP14及ERBB2 是公知的，如上所述，其获得方法也是已知的。所以，可以通过克隆 上述基因制备作为本发明的组合物的多核苷酸。
构成本发明的组合物的多核苷酸可以使用DNA自动合成装置化 学合成得到。通常可以使用亚磷酰胺法进行合成，可以利用该方法自 动合成至多约100个碱基的单链DNA。DNA自动合成装置可以从例 如Polygen公司、ABI公司、Applied BioSystems公司等购买。
本发明的多核苷酸也可以通过cDNA克隆法制备。可以从表达作 为本发明中的靶标的上述基因的肾组织等生物组织中提取总RNA，将 该总RNA用寡聚dT纤维素柱处理得到聚A(+)RNA，通过RT-PCR 法由该聚A(+)RNA制备cDNA库，通过杂交筛选、表达筛选、抗体 筛选等进行筛选，从该cDNA库得到目标cDNA克隆。可以根据需要， 利用PCR法扩增cDNA克隆。可以基于序列号1～50表示的碱基序列， 从15～100个连续碱基序列中选择并合成探针或引物。例如在 Sambrook，J.&Russel，D.著、Molecular Cloning，A LABORATORY MANUAL、Cold Spring Harbor Laboratory Press、2001年1月15日出版、 的第1卷7.42～7.45、第2卷8.9～8.17中记载了cDNA克隆技术。
3.2抗体组合物
本发明的组合物可以含有上述2中的II组中记载的抗体、其片段或 化学修饰衍生物作为肾癌诊断用探针。上述组合物对于体外检测、确 定或预测患有肾癌的受试者的肾癌存在及/或转移是有用的。此处， 转移的预测可以推导出受试者术后的预后良好、不良的预测结果。
(A)本发明的抗体组合物的第1例是含有针对下述多肽的1种或 多种抗体、该抗体的片段、或其化学修饰衍生物的组合物，所述多肽 具有上述II组(f)中记载的序列号101～110、112～120、122～147表 示的氨基酸序列。
本发明的组合物中可以进一步含有针对下述多肽、其变异体或其 片段的1种或多种抗体、该抗体的片段或化学修饰衍生物，所述多肽 具有序列号111、121、148～150表示的氨基酸序列。通过并用上述抗 体，可以提高预后预测的准确度。
即，根据本发明，为了检测作为肾癌预后预测用或肾癌转移标记 物的由PABPN1、PINK1、TFF2、EIF3S9、MAX、MLL4、CACNB2、 ZMYND11、BAT2、NRBP、MCM3AP、COL4A1、MKNK1、BBC3、 FLJ10359、DPT、C10orf76、DIA1、PBK、PRKD2、KRT19、FLJ23436、 NPHS2、C3orf14、AGTR2、HTR1F、KIF3B、DCN、STK22C、 DKFZp566C0424、CNR1、HOMER3、GPR2、FLJ12442、XLKD1、 CASKIN2、COL5A2、BRD3、ATP6V0A4、PRODH2、EPHB2、LYAR、 COX6B、PRH1、LAPTM5、RPS6KA4、GCC2、FGF2、MMP14及ERBB2 基因编码的多肽、其同源物、或其变异体或衍生物，能够组合使用1 个或多个、优选2个以上针对上述多肽的抗体。
(B)本发明的抗体组合物的第2例是含有针对下述多肽的1种或 多种抗体、该抗体的片段、或其化学修饰衍生物的组合物，所述多肽 含有上述II组(g)、(h)分别记载的序列号151～160、191、序列号 161～190、192～197表示的氨基酸序列。
上述多肽由表1、表2及表3所述的基因编码。各基因的碱基序列 可以通过登录NCBI主页根据表中所示的基因名容易地获得。
上述多肽可以利用DNA重组技术得到。例如，可以将如上所述得 到的cDNA克隆整合到表达载体中，通过培养由该载体转化或转染的 原核或真核宿主细胞，从该细胞或培养上清液中得到上述多肽。载体 及表达系统可以从Novagen公司、宝酒造、第一化学药品、Qiagen公 司、Stratagene公司、Promega公司、Roche Diagnositics公司、Invitrogen 公司、Genetics Institute公司、Amersham Bioscience公司等购买。
作为宿主细胞，可以使用细菌等原核细胞(例如大肠杆菌、枯草 杆菌)、酵母(例如酿酒酵母)、昆虫细胞(例如Sf细胞)、哺乳动 物细胞(例如COS、CHO、BHK)等。
载体中除含有编码该多肽的DNA以外，还可以含有调节元件，例 如启动子、增强子、多聚腺苷酸化信号、核糖体结合部位、复制起点、 终止子、选择标记等。为了容易进行多肽的纯化，可以将多肽制成在 多肽的C末端或N末端结合了标记肽的融合多肽。作为代表性的标记 肽，可以举出6～10个残基的组氨酸重复序列、FLAG、myc肽、GFP 多肽等，但标记肽并不限定于此。DNA重组技术记载于Sambrook，J. &Russel，D.(参见上述记载)。
在不结合标记肽的状态下制备本发明的多肽时，作为其纯化方 法，例如可以举出利用超滤、盐析、凝胶过滤、离子交换色谱等的方 法。除此之外，还可以使用组合亲和色谱、HPLC、疏水性色谱、等 电点色谱等的方法。另一方面，在该蛋白质上结合组氨酸重复序列、 FLAG、myc、GFP等标记肽时，可以举出适合通常使用的各种标记肽 的亲和色谱法。可以构建能易于分离、纯化的表达载体。特别是构建 能以多肽和标记肽的融合多肽的形式进行表达的表达载体，利用基因 工程技术制备该多肽时，也可容易地进行分离、纯化。
本发明中上述多肽的变异体如上述定义所述，是在序列号101～ 197表示的氨基酸序列或其部分序列中，缺失、置换、添加或插入1个 以上、优选1个或数个氨基酸的变异体、或者与该氨基酸序列或其部 分序列具有约80％以上、约85％以上、优选约90％以上、较优选约95 ％以上、约97％以上、约98％以上、约99％以上的同源性百分比的变 异体。上述变异体例如包括不同于人的哺乳动物种的同源物、以人的 多态性变异或剪接变异为基础的变异体等天然变异体。
本发明中上述多肽或变异体的片段，由该多肽的氨基酸序列的至 少5个、至少7个、至少10个、至少15个、优选至少20个、至少25个、 较优选至少30个、至少40个、至少50个连续氨基酸残基构成，并保持 1个或几个表位。上述片段可以免疫特异性地与本发明的抗体或其片 段结合。推测上述多肽可能在存在于生物体内的蛋白酶或肽酶等酶的 作用下被切断而形成片段，以片段形式存在。
识别如上所述得到的多肽的抗体可以通过抗体的抗原结合部位 特异性结合该多肽。具体而言，可以将具有序列号101～197的氨基酸 序列的多肽或其片段、其变异体多肽或融合多肽等，分别用作用于产 生免疫反应性抗体的免疫原。
更具体而言，多肽、片段、变异体、融合多肽等含有促使抗体形 成的抗原决定簇或表位，上述抗原决定簇或表位可以是直链，也可以 是较高级结构(断开)。需要说明的是，该抗原决定簇或表位可以通 过本领域已知的所有表位分析法、例如噬菌体展示技术(Phage display)、反向免疫遗传学技术(reverse immunogenetics)等进行确定。
利用本发明的多肽能诱导所有种类的抗体。如果分离该多肽的全 部或一部分或表位，那么使用常规技术即可制备多克隆抗体及单克隆 抗体中的任一种。方法例如包括Kennet等(主编)，Monoclonal Antibodies，Hybridomas：A New Dimension in Biological Analyses， Ple num Press，NewYork，1980中列举的方法。
多克隆抗体可以通过用本发明的多肽免疫禽类(例如鸡等)、哺 乳动物(例如家兔、山羊、马、绵羊、小鼠等)等动物进行制备。可 以适当组合硫酸铵分级分离、离子交换色谱、亲和色谱等方法，从被 免疫的动物的血液中纯化目标抗体。
单克隆抗体可以通过包括利用常规技术在小鼠中生产杂交瘤细 胞株的方法得到，所述杂交瘤细胞株产生对各多肽特异的单克隆抗 体。用于生产上述杂交瘤细胞株的1种方法如下所述：用本发明的酶 多肽免疫动物，从被免疫的动物中采集脾细胞，使该脾细胞与骨髓瘤 细胞株融合，由此制备杂交瘤细胞，然后鉴定生产与该酶结合的单克 隆抗体的杂交瘤细胞。单克隆抗体可以通过常规技术回收。
作为本发明的抗体，只要是能与本发明的靶多肽或其片段特异性 结合的抗体即可，没有特别限定，可以使用单克隆抗体，也可以使用 多克隆抗体，优选使用单克隆抗体。其他抗体包括重组抗体、合成酶、 多特异性抗体(例如，双特异性抗体)、单链抗体、抗体片段等。上 述抗体的例子为Fab、F(ab’)2、scFv、Fv、dsFv等。本发明抗体的 球蛋白类型只要具有上述特征即可，没有特别限定，可以是IgG、IgM、 IgA、IgE、IgD中的任一种。
<单克隆抗体的制备>
(1)免疫及抗体产生细胞的采集
对哺乳动物例如大鼠、小鼠(例如近交系小鼠Balb/c)、家兔等 给予由靶多肽构成的免疫原。免疫原的1次给药量可以根据免疫动物 种类、给药途径等适当确定，每1只动物给药约50～200μg。主要通过 在皮下、腹腔内注入免疫原进行免疫。另外，免疫的间隔没有特别限 定，初次免疫后，间隔数日至数周，优选间隔1～4周，进行2～10次、 优选3～4次加强免疫。初次免疫后，利用ELISA(酶联免疫吸附测定 (Enzyme-Linked Immuno Sorbent Assay))法等反复测定免疫动物 血清中的抗体值，抗体值达到平台时，向静脉内或腹腔内注射免疫原， 进行最终免疫。从最终免疫日起2～5日后，优选3日后，采集抗体产生 细胞。作为抗体产生细胞，可以举出脾细胞、淋巴结细胞、外周血细 胞等，优选脾细胞或局部淋巴结细胞。
(2)细胞融合
制备产生对各靶多肽特异的单克隆抗体的杂交瘤细胞株。该杂交 瘤可以通过常规技术进行生产并鉴定。用于生产该杂交瘤细胞株的方 法之一是用本发明的蛋白质免疫动物，从被免疫的动物中采集脾细 胞，使该脾细胞与骨髓瘤细胞株融合，由此生成杂交瘤细胞，鉴定产 生与该酶结合的单克隆抗体的杂交瘤细胞株。作为能与抗体产生细胞 融合的骨髓瘤细胞株，可以使用通常能购买到的小鼠等动物的细胞 株。作为使用的细胞株，优选具有下述性质的细胞株，即具有药剂选 择性，并具有在未融合状态下在HAT选择培养基(含有次黄嘌呤、氨 基蝶呤、胸腺嘧啶)中不能存活，只有在与抗体产生细胞融合的状态 下才能存活的性质。细胞株优选来自与免疫动物同种系的动物的细 胞。作为骨髓瘤细胞株的具体例，可以举出来自BALB/c小鼠的次黄 嘌呤·鸟嘌呤·磷酸核糖基·转移酶(HGPRT)缺陷细胞株P3X63- Ag.8株(ATCC TIB9)等。
接下来使上述骨髓瘤细胞株与抗体产生细胞进行细胞融合。细胞 融合如下进行：在不含有血清的DMEM、RPMI-1640培养基等动物 细胞培养用培养基中，以约1∶1～20∶1的比例混合抗体产生细胞和 骨髓瘤细胞株，在细胞融合促进剂的存在下进行融合反应。作为细胞 融合促进剂，可以使用浓度约为10～80％、平均分子量为1500～4000 道尔顿的聚乙二醇等。另外，视情况的不同，为了提高融合效率，可 以并用二甲基亚砜等辅助剂。还可以使用利用电刺激(例如电穿孔) 的市售的细胞融合装置使抗体产生细胞和骨髓瘤细胞株融合。
(3)杂交瘤的筛选及克隆
从细胞融合处理后的细胞中筛选目标杂交瘤。作为筛选方法，使 用例如含有胎牛血清的RPMI-1640培养基等适当稀释细胞悬浮液 后，以约200万个细胞/孔接种到微孔板上，向各孔中加入选择培养基， 并在以后适当更换选择培养基，进行培养。培养温度为20～40℃、优 选为约37℃。骨髓瘤细胞是HGPRT缺陷株或胸苷激酶缺陷株时，可以 通过使用含有次黄嘌呤·氨基蝶呤·胸腺嘧啶核苷的选择培养基(HAT 培养基)，仅选择性培养、增殖具有抗体产生能力的细胞与骨髓瘤细 胞株的杂交瘤。结果在用选择培养基开始培养后，生长约14天左右的 细胞可以作为杂交瘤被得到。
接下来，对进行了增殖的杂交瘤的培养上清液中是否存在目标抗 体进行筛选。杂交瘤的筛选可以按照常规方法进行，没有特别限定。 例如，采集作为杂交瘤培养的包含在孔中的培养上清液的一部分，通 过酶免疫测定法(EIA：Enzyme Immuno Assay、及ELISA)、放射免 疫测定法(RIA：Radio Immuno Assay)等进行筛选。融合细胞的克 隆通过极限稀释法等进行，从而最终确立产生单克隆抗体的细胞即杂 交瘤。本发明的杂交瘤如后所述，在RPMI-1640、DMEM等基本培 养基中的培养稳定，并能产生、分泌与靶多肽特异性反应的单克隆抗 体。
(4)抗体的回收
单克隆抗体可以利用常规技术进行回收。即，作为从确立的杂交 瘤中采集单克隆抗体的方法，可以采用通常的细胞培养法或腹水形成 法等。采用细胞培养法时，在通常的培养条件(例如，37℃、5％CO2 浓度)下，在含有10％胎牛血清的RPMI-1640培养基、MEM培养基 或无血清培养基等动物细胞培养基中培养杂交瘤2～10日，从该培养上 清液中获得抗体。采用腹水形成法的情况下，向与提供骨髓瘤细胞的 哺乳动物同种系的动物的腹腔内给予约1000万个杂交瘤，使杂交瘤大 量增殖。并在1～2周后采集腹水或血清。
对于上述抗体的采集方法，在需要纯化抗体的情况下，可以通过 适当选择硫酸铵盐析法、离子交换色谱法、亲和色谱法、凝胶过滤色 谱法等公知的方法，或组合使用上述方法，得到纯化的单克隆抗体。
<多克隆抗体的制备>
制备多克隆抗体时，与上述相同，免疫家兔等动物，从最终免疫 日起6～60天后，利用酶免疫测定法(EIA及ELISA)、放射免疫测定 法(RIA)等测定抗体值，在显示最大抗体值的当天采血，得到抗血 清。然后，利用ELISA法等测定抗血清中的多克隆抗体的反应性。
<化学修饰衍生物>
本发明的抗体或其片段可以是经化学修饰的衍生物。例如，可以 举出利用酶、荧光团、放射性同位素等标记得到的标记化衍生物，或 乙酰化、酰化、烷基化、磷酸化、硫酸化、糖基化衍生物等化学修饰 衍生物。
作为标记物质，在酶免疫测定法中，可以使用过氧化物酶(POD)、 碱性磷酸酶、β-半乳糖苷酶、脲酶、过氧化氢酶、葡萄糖氧化酶、 乳酸脱氢酶、淀粉酶等酶或生物素-抗生物素蛋白复合体，荧光免疫 测定法中，可以使用异硫氰酸荧光素、四甲基罗丹明异硫氰酸盐、取 代异硫氰酸罗丹明、二氯三嗪异硫氰酸盐、Alexa或AlexaFluoro等荧 光性物质或荧光团，放射免疫测定法中，可以使用氚、碘(131I，125I， 123I，121I)、磷(32P)、硫(35S)、金属类(例如68Ga，67Ga，68Ge， 54Mn，99Mo，99Tc，133Xe等)等放射性同位素。发光免疫测定法可以 使用NADH-、FMNH2-、荧光素酶类、鲁米诺-过氧化氢-POD 类、吖啶酯类或二氧杂环丁烷化合物类等发光性分子、发光物质、生 物发光物质。
另外，根据需要，还可以利用抗生物素蛋白-生物素系统或链霉 抗生物素蛋白-生物素系统，此种情况下，可以在本发明的抗体或其 片段上结合例如生物素。对于标记物质和抗体的结合法，在酶免疫测 定法中，可以使用戊二醛法、马来酰亚胺法、吡啶基二硫化物或高碘 酸法等公知的方法，放射免疫测定法中，可以使用氯胺T法、Bolton -Hunter法等公知的方法。
4.肾癌诊断用及/或肾癌预后预测或转移预测用试剂盒
4.1核酸试剂盒
本发明还提供用于体外检测、确定或预测肾癌的存在或肾癌的转 移、或预后预测的试剂盒，其中含有上述2中的I组中记载的多核苷 酸、其变异体及/或其片段中的1种或几种。
本发明的试剂盒中可以含有下述I组中的核酸探针。上述各探针可 以单独或组合收纳在适当的容器中。
即、本发明的试剂盒可以含有下述多核苷酸中的至少一种，所述 多核苷酸为含有序列号1～10、12～20、22～47表示的碱基序列的多 核苷酸、含有其互补序列的多核苷酸、与上述多核苷酸在严格条件下 杂交的多核苷酸、或上述多核苷酸的片段。
本发明的试剂盒可以进一步含有下述多核苷酸中的至少一种，所 述多核苷酸为含有序列号11、21、48～50表示的碱基序列的多核苷酸、 含有其互补序列的多核苷酸、与上述多核苷酸在严格条件下杂交的多 核苷酸、或上述多核苷酸的片段。
本发明的试剂盒中可以含有的多核苷酸片段例如是选自下述(1) ～(5)中的1种以上DNA：
(1)序列号1～10、11、12～20、21、22～47、48～50表示的碱 基序列或其互补序列中，含有15个以上连续碱基的DNA。
(2)序列号1～10、11、12～20、21、22～47、48～50表示的碱 基序列或其互补序列中，含有60个以上连续碱基的DNA。
(3)序列号1～10、11、12～20、21、22～47、48～50表示的碱 基序列或其互补序列中，分别含有序列号51～60、61、62～70、71、 72～97、98～100表示的碱基序列或其互补序列、且含有60个以上连 续碱基的DNA。
(4)由序列号51～60、61、62～70、71、72～97、98～100表示 的碱基序列构成的DNA。
(5)含有与序列号51～60、61、62～70、71、72～97、98～100 表示的碱基序列互补的碱基序列的DNA。
优选实施方案中，上述多核苷酸是由序列号1～10、12～20、22～ 47中任一个表示的碱基序列构成的多核苷酸、由其互补序列构成的多 核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、或其含有15 个以上连续碱基的片段。
其它优选实施方案中，本发明的试剂盒除含有上述多核苷酸之 外，还可以含有由序列号11、21、48～50表示的碱基序列构成的多核 苷酸、由其互补序列构成的多核苷酸、与上述多核苷酸在严格条件下 杂交的多核苷酸、或其含有15个以上连续碱基的片段。
优选实施方案中，上述片段可以是含有15个以上、优选60个以上 的连续碱基的多核苷酸。
其它优选实施方案中，上述片段是在序列号1～10、11、12～20、 21、22～47、48～50中任一个表示的碱基序列中，分别含有序列号51～ 60、61、62～70、71、72～97、98～100中任一个表示的碱基序列、 且含有60个以上连续碱基的多核苷酸、或含有与该多核苷酸的序列互 补的碱基序列的多核苷酸。
其它优选实施方案中，上述片段是含有序列号51～60、61、62～ 70、71、72～97、98～100中任一个表示的碱基序列的多核苷酸。
其它优选实施方案中，上述片段是含有与序列号51～60、61、62～ 70、71、72～97、98～100中任一个表示的碱基序列互补的碱基序列 的多核苷酸。
其它优选实施方案中，上述片段是由序列号51～60、61、62～70、 71、72～97、98～100中任一个表示的碱基序列构成的多核苷酸。
上述组合的具体例为，含有序列号1及2的碱基序列或其互补序列 的多核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、及/或 其片段，含有序列号1～3的碱基序列或其互补序列的多核苷酸、与上 述多核苷酸在严格条件下杂交的多核苷酸、及/或其片段，含有序列 号1～4的碱基序列或其互补序列的多核苷酸、与上述多核苷酸在严格 条件下杂交的多核苷酸、及/或其片段，含有序列号1～5的碱基序列 或其互补序列的多核苷酸、与上述多核苷酸在严格条件下杂交的多核 苷酸、及/或其片段，含有序列号1～6的碱基序列或其互补序列的多 核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、及/或其片 段，含有序列号1～7的碱基序列或其互补序列的多核苷酸、与上述多 核苷酸在严格条件下杂交的多核苷酸、及/或其片段，含有序列号1～ 8的碱基序列或其互补序列的多核苷酸、与上述多核苷酸在严格条件 下杂交的多核苷酸、及/或其片段，含有序列号1～9的碱基序列或其 互补序列的多核苷酸、与上述多核苷酸在严格条件下杂交的多核苷 酸、及/或其片段，含有序列号1～10的碱基序列或其互补序列的多 核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、或其片段， 含有序列号1～11的碱基序列或其互补序列的多核苷酸、与上述多核 苷酸在严格条件下杂交的多核苷酸、及/或其片段，含有序列号1～ 12的碱基序列或其互补序列的多核苷酸、与上述多核苷酸在严格条件 下杂交的多核苷酸、及/或其片段，含有序列号1～13的碱基序列或 其互补序列的多核苷酸、与上述多核苷酸在严格条件下杂交的多核苷 酸、及/或其片段，含有序列号1～14的碱基序列或其互补序列的多 核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、及/或其片 段，含有序列号1～15的碱基序列或其互补序列的多核苷酸及/或其 片段，含有序列号1～16的碱基序列或其互补序列的多核苷酸、与上 述多核苷酸在严格条件下杂交的多核苷酸、及/或其片段，含有序列 号1～17的碱基序列或其互补序列的多核苷酸及/或其片段，含有序 列号1～18的碱基序列或其互补序列的多核苷酸、与上述多核苷酸在 严格条件下杂交的多核苷酸、及/或其片段，含有序列号1～19的碱 基序列或其互补序列的多核苷酸、与上述多核苷酸在严格条件下杂交 的多核苷酸、及/或其片段，含有序列号1～20的碱基序列或其互补 序列的多核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、及 /或其片段，含有序列号1～21的碱基序列或其互补序列的多核苷酸、 与上述多核苷酸在严格条件下杂交的多核苷酸、及/或其片段，含有 序列号1～22的碱基序列或其互补序列的多核苷酸、与上述多核苷酸 在严格条件下杂交的多核苷酸、及/或其片段，含有序列号1～23的 碱基序列或其互补序列的多核苷酸、与上述多核苷酸在严格条件下杂 交的多核苷酸、及/或其片段，含有序列号1～24的碱基序列或其互 补序列的多核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、 及/或其片段，含有序列号1～25的碱基序列或其互补序列的多核苷 酸、与上述多核苷酸在严格条件下杂交的多核苷酸、及/或其片段， 含有序列号1～26的碱基序列或其互补序列的多核苷酸、与上述多核 苷酸在严格条件下杂交的多核苷酸、及/或其片段，含有序列号1～ 27的碱基序列或其互补序列的多核苷酸、与上述多核苷酸在严格条件 下杂交的多核苷酸、及/或其片段，含有序列号1～28的碱基序列或 其互补序列的多核苷酸、与上述多核苷酸在严格条件下杂交的多核苷 酸、及/或其片段，含有序列号1～29的碱基序列或其互补序列的多 核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、及/或其片 段，含有序列号1～30的碱基序列或其互补序列的多核苷酸、与上述 多核苷酸在严格条件下杂交的多核苷酸、及/或其片段，含有序列号 1～31的碱基序列或其互补序列的多核苷酸、与上述多核苷酸在严格 条件下杂交的多核苷酸、及/或其片段，含有序列号1～32的碱基序 列或其互补序列的多核苷酸、与上述多核苷酸在严格条件下杂交的多 核苷酸、及/或其片段，含有序列号1～33的碱基序列或其互补序列 的多核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、及/或 其片段，含有序列号1～34的碱基序列或其互补序列的多核苷酸、与 上述多核苷酸在严格条件下杂交的多核苷酸、及/或其片段，含有序 列号1～35的碱基序列或其互补序列的多核苷酸、与上述多核苷酸在 严格条件下杂交的多核苷酸、及/或其片段，含有序列号1～36的碱 基序列或其互补序列的多核苷酸、与上述多核苷酸在严格条件下杂交 的多核苷酸、及/或其片段，含有序列号1～37的碱基序列或其互补 序列的多核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、及 /或其片段，含有序列号1～38的碱基序列或其互补序列的多核苷酸、 与上述多核苷酸在严格条件下杂交的多核苷酸、及/或其片段，含有 序列号1～39的碱基序列或其互补序列的多核苷酸、与上述多核苷酸 在严格条件下杂交的多核苷酸、及/或其片段，含有序列号1～40的 碱基序列或其互补序列的多核苷酸、与上述多核苷酸在严格条件下杂 交的多核苷酸、及/或其片段，含有序列号1～41的碱基序列或其互 补序列的多核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、 及/或其片段，含有序列号1～42的碱基序列或其互补序列的多核苷 酸、与上述多核苷酸在严格条件下杂交的多核苷酸、及/或其片段， 含有序列号1～43的碱基序列或其互补序列的多核苷酸、与上述多核 苷酸在严格条件下杂交的多核苷酸、及/或其片段，含有序列号1～ 44的碱基序列或其互补序列的多核苷酸、与上述多核苷酸在严格条件 下杂交的多核苷酸、及/或其片段，含有序列号1～45的碱基序列或 其互补序列的多核苷酸、与上述多核苷酸在严格条件下杂交的多核苷 酸、及/或其片段，含有序列号1～46的碱基序列或其互补序列的多 核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、及/或其片 段，含有序列号1～47的碱基序列或其互补序列的多核苷酸、与上述 多核苷酸在严格条件下杂交的多核苷酸、及/或其片段，含有序列号 1～48的碱基序列或其互补序列的多核苷酸、与上述多核苷酸在严格 条件下杂交的多核苷酸、及/或其片段，含有序列号1～49的碱基序 列或其互补序列的多核苷酸、与上述多核苷酸在严格条件下杂交的多 核苷酸、及/或其片段，含有序列号1～50的碱基序列或其互补序列 的多核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、及/或 其片段。
根据其它较优选实施方案，本发明的试剂盒可以含有下述多核苷 酸中的2种以上～全部，所述多核苷酸为含有序列号51～97、98～100 表示的碱基序列或其互补序列的多核苷酸。
其它组合的具体例为含有序列号1～19、48的碱基序列或其互补 序列或由上述序列构成的多核苷酸及/或其片段。
其它组合的具体例还有含有序列号20～47、49及50的碱基序列或 其互补序列或由上述序列构成的多核苷酸及/或其片段。
本发明中，上述多核苷酸片段的大小是各多核苷酸碱基序列中下 述范围的连续碱基数，例如15～序列的全部碱基数、15～5000个碱基、 15～4500个碱基、15～4000个碱基、15～3500个碱基、15～3000个碱 基、15～2500个碱基、15～2000个碱基、15～1500个碱基、15～1000 个碱基、15～900个碱基、15～800个碱基、15～700个碱基、15～600 个碱基、15～500个碱基、15～400个碱基、15～300个碱基、15～250 个碱基、15～200个碱基、15～150个碱基、15～140个碱基、15～130 个碱基、15～120个碱基、15～110个碱基、15～100个碱基、15～90 个碱基、15～80个碱基、15～70个碱基、15～60个碱基、15～50个碱 基、15～40个碱基、15～30个碱基或15～25个碱基，25～序列的全部 碱基数、25～1000个碱基、25～900个碱基、25～800个碱基、25～700 个碱基、25～600个碱基、25～500个碱基、25～400个碱基、25～300 个碱基、25～250个碱基、25～200个碱基、25～150个碱基、25～140 个碱基、25～130个碱基、25～120个碱基、25～110个碱基、25～100 个碱基、25～90个碱基、25～80个碱基、25～70个碱基、25～60个碱 基、25～50个碱基或25～40个碱基；50～序列的全部碱基数、50～1000 个碱基、50～900个碱基、50～800个碱基、50～700个碱基、50～600 个碱基、50～500个碱基、50～400个碱基、50～300个碱基、50～250 个碱基、50～200个碱基、50～150个碱基、50～140个碱基、50～130 个碱基、50～120个碱基、50～110个碱基、50～100个碱基、50～90 个碱基、50～80个碱基、50～70个碱基或50～60个碱基；60～序列的 全部碱基数、60～1000个碱基、60～900个碱基、60～800个碱基、60～ 700个碱基、60～600个碱基、60～500个碱基、60～400个碱基、60～ 300个碱基、60～250个碱基、60～200个碱基、60～150个碱基、60～ 140个碱基、60～130个碱基、60～120个碱基、60～110个碱基、60～ 100个碱基、60～90个碱基、60～80个碱基或60～70个碱基等。
构成本发明的试剂盒的上述组合只是列举，其他各种可能的组合 都包括在本发明中。
本发明的试剂盒除了上述说明的本发明的多核苷酸、其变异体或 其片段之外，还可以含有已知或将来发现的能够检测肾癌或预测肾癌 转移或预测预后的多核苷酸。
4.2抗体试剂盒
另外，本发明还提供一种用于体外检测、确定或预测肾癌的存在 或肾癌的转移或预后预测的试剂盒，其中包含上述2中的II组中记载的 抗体、其片段或其化学修饰衍生物、上述3.2中记载的抗体、其片段或 其化学修饰衍生物中的1种或几种。
本发明的试剂盒中可以含有下述II组(f)、(g)及(h)中的抗 体、其片段或其化学修饰衍生物作为探针。上述各探针可以单独或组 合收纳在适当的容器中。
探针的组合例如下所示。
第1例探针为了检测作为肾癌预后预测用或肾癌转移标记物的 PABPN1、PINK1、TFF2、EIF3S9、MAX、MLL4、CACNB2、ZMYND11、 BAT2、NRBP、MCM3AP、COL4A1、MKNK1、BBC3、FLJ10359、 DPT、C10orf76、DIA1、PBK、PRKD2、KRT19、FLJ23436、NPHS2、 C3orf14、AGTR2、HTR1F、KIF3B、DCN、STK22C、DKFZp566C0424、 CNR1、HOMER3、GPR2、FLJ12442、XLKD1，CASKIN2、COL5A2、 BRD3、ATP6V0A4、PRODH2、EPHB2、LYAR、COX6B、PRH1、 LAPTM5、RPS6KA4、GCC2、FGF2、MMP14及ERBB2基因编码的多 肽、其同源物、或其变异体或衍生物而含有1种或几种、优选2种以上 针对上述多肽、其变异体或其片段的抗体。
具体而言，试剂盒中含有的探针是与具有序列号101～110、112～ 120、122～147表示的氨基酸序列的多肽、其变异体、或其片段中的 至少1个特异性结合的1种或几种抗体、该抗体的片段、或其化学修饰 衍生物。
该试剂盒中可以进一步含有针对具有序列号11I、121、148～150 表示的氨基酸序列的多肽的抗体、该抗体的片段或其化学修饰衍生 物。通过并用，能提高转移的预测或术后预后的预测准确度。
第2例探针为针对下述多肽的1种或多种抗体、其片段、或其化学 修饰衍生物，所述多肽作为肾癌标记物含有上述II组(g)、(h)分 别记载的序列号151、153、155～160、序列号161～190表示的氨基酸 序列
该试剂盒中还可以包含针对含有序列号152、154、191、192～197 表示的氨基酸序列的多肽的抗体、其片段或其化学修饰衍生物。通过 并用，能提肾癌检测的准确度。
本发明的试剂盒中含有的抗体可以单独存在，也可以以混合物的 状态存在，或与固相载体结合存在，也可以以游离状态存在。另外， 本发明的试剂盒可以含有标记二抗、载体、清洗缓冲液、试样稀释液、 酶底物、反应停止液、纯化的作为标准物质的标记物(靶)多肽、使 用说明书等。
5.DNA芯片
本发明还提供用于检测肾癌或预测肾癌预后或预测转移的DNA 芯片，所述DNA芯片单独或组合、优选组合使用与上述3及/或4中记 载的本发明的组合物及/或试剂盒中含有的物质相同的多核苷酸、变异 体或片段。
作为DNA芯片的基板，只要是能够将DNA固定化的基板即可，没 有特别限定，可以举出载玻片、硅制芯片、聚合物制芯片及尼龙膜等。 另外，可以对上述基板进行聚L赖氨酸涂布或导入氨基、羧基等官能 团等表面处理。
另外，固定化法只要是通常使用的方法即可，没有特别限定，可 以举出以下方法：使用被称为点样器(spotter)或阵列点样仪(arrayer) 的高密度分液器点样DNA的方法、或使用通过压电元件等从喷嘴喷射 微量的液滴的装置(喷墨)将DNA喷射到基板上的方法、或在基板上 依次进行核苷酸合成的方法。使用高密度分液器时，例如如下进行固 定化：在具有多个孔的平板的各孔中装入不同的基因溶液，用针取出 该溶液，然后依次点到基板上。使用喷墨法时，如下进行固定化：从 喷嘴喷射基因，将基因高速地排列在基板上。在基板上合成DNA时， 如下进行固定化：用能在光的作用下离去的官能团保护与基板结合的 碱基，通过使用掩模只对特定部位的碱基曝光，使官能团离去。然后， 反复进行向反应液中加入碱基、使其与基板上的碱基偶联的步骤。
能够被固定化的多核苷酸是上述说明的本发明的全部多核苷酸。
例如，上述多核苷酸可以含有以下1种或几种多核苷酸或其片段。
(1)由序列号1～50表示的碱基序列构成的多核苷酸、其变异体、 或其含有15个以上连续碱基的片段。
(2)含有序列号1～50表示的碱基序列的多核苷酸。
(3)由序列号1～10、12～20、22～47表示的碱基序列构成的多 核苷酸、其变异体、或其含有15个以上连续碱基的片段。
(4)含有序列号1～10、12～20、22～47表示的碱基序列的多核 苷酸、其变异体、或其含有15个以上连续碱基的片段。
(5)由与序列号1～10、12～20、22～47表示的碱基序列互补的 碱基序列构成的多核苷酸、其变异体、或其含有15个以上连续碱基的 片段。
(6)含有与序列号1～10、12～20、22～47表示的碱基序列互补 的碱基序列的多核苷酸。
(7)与下述DNA在严格条件下杂交的多核苷酸、或其含有15个 以上连续碱基的片段，所述DNA由与序列号1～10、12～20、22～47 表示的各个碱基序列互补的碱基序列构成。
(8)与下述DNA在严格条件下杂交的多核苷酸、或其含有15个 以上连续碱基的片段，所述DNA由序列号1～10、12～20、22～47表 示的各个碱基序列构成。
(9)由序列号11、21、48～50表示的碱基序列构成的多核苷酸、 其变异体、或其含有15个以上连续碱基的片段。
(10)含有序列号11、21、48～50表示的碱基序列的多核苷酸、 其变异体、或其含有15个以上连续碱基的片段。
(11)由与序列号11、21、48～50表示的碱基序列互补的碱基序 列构成的多核苷酸、其变异体、或其含有15个以上连续碱基的片段。
(12)含有与序列号11、21、48～50表示的碱基序列互补的碱基 序列的多核苷酸。
(13)与下述DNA在严格条件下杂交的多核苷酸、或其含有15个 以上连续碱基的片段，所述DNA由与序列号11、21、48～50表示的各 个碱基序列互补的碱基序列构成。
(14)与下述DNA在严格条件下杂交的多核苷酸、或其含有15个 以上连续碱基的片段，所述DNA由序列号11、21、48～50表示的各个 碱基序列构成。
(15)在序列号1～10、12～20、22～47表示的碱基序列或其互 补序列的各序列中、含有15个以上连续碱基的多核苷酸。
(16)序列号1～10、12～20、22～47表示的碱基序列或其互补 序列的各序列中、含有60个以上连续碱基的多核苷酸。
(17)序列号11、21、48～50表示的碱基序列或其互补序列的各 序列中、含有15个以上连续碱基的多核苷酸。
(18)序列号11、21、48～50表示的碱基序列或其互补序列的各 序列中、含有60个以上连续碱基的多核苷酸。
(19)序列号1～10、12～20、22～47表示的碱基序列中，分别 含有序列号51～60、62～70、72～97表示的碱基序列、且含有60个以 上连续碱基的多核苷酸。
(20)与序列号1～10、12～20、22～47表示的碱基序列互补的 序列中，分别含有与序列号51～60、62～70、72～97表示的碱基序列 互补的序列、且含有60个以上连续碱基的多核苷酸。
(21)序列号11、21、48～50表示的碱基序列中，分别含有序列 号61、71、98～100表示的碱基序列、且含有60个以上连续碱基的多 核苷酸。
(22)与序列号11、21、48～50表示的碱基序列互补的序列中， 分别含有与序列号61、71、98～100表示的碱基序列互补的序列、且 含有60个以上连续碱基的多核苷酸。
根据优选实施方案，本发明的试剂盒可以包含2种以上至全部的 含有序列号51～60、61、62～70、71、72～97、98～100表示的碱基 序列或其互补序列的多核苷酸。
本发明中，固定化的多核苷酸可以为基因组DNA、cDNA、RNA、 合成DNA、合成RNA中的任一种，可以为单链也可以为双链。
作为能够检测、测定靶基因、RNA或cDNA的表达水平的DNA芯 片的例子，可以举出Affymetrix公司的Gene Chip Human Genome U133 Plus 2.0Array、Agilent公司的Whole human genome oligo microarray、 Takara Bio公司的IntelliGene(注册商标)HS Human Expression CHIP、 具有凹凸结构的聚甲基丙烯酸甲酯制DNA芯片基板(日本特开2004 -264289)等。
DNA微阵列的制作例如可以使用在固相表面固定预先制备的探 针的方法。在固相表面固定预先制备的多核苷酸探针的方法如下：合 成导入了官能团的多核苷酸，在经过表面处理的固相载体表面上点样 寡核苷酸或多核苷酸，使其共价键合(例如、J.B.Lamture等、 Nucleic.Acids.Research、1994年，第22卷，p.2121-2125、Z.Guo等、 Nucleic.Acids.Research、1994年，第22卷，p.5456-5465)。多核苷酸 通常通过间隔臂(spacer)或交联剂(crosslinker)与经过表面处理的 固相载体共价键合。还已知使聚丙烯酰胺凝胶的微小片排列在玻璃表 面上，使合成多核苷酸与其共价键合的方法(G.Yershov等、Proceedings ofthe National Academic Sciences U.S.A.、1996年，第94卷，p.4913)。 还已知下述方法：在二氧化硅微阵列上制作微小电极的阵列，在电极 上设置含有链霉抗生物素蛋白的琼脂糖的渗透层，形成反应部位，通 过使该部位带正电，固定生物素化多核苷酸，通过控制部位的电荷， 能高速且严格地进行杂交(R.G.Sosnowski等、Proceedings of the National Academic Sciences U.S.A.、1997年，第94卷，p.1119-1123)。
6.肾癌存在的检测、确定方法及/或肾癌的预后或转移预测方法
本发明提供一种方法，所述方法使用本发明的组合物、试剂盒、 DNA芯片、或它们的组合，通过将来自受试者的肾癌细胞生物试样中 靶核酸的表达水平，与来自预后不良肾癌患者群体的肾癌细胞中靶核 酸的表达水平及/或来自预后良好患者群体的肾癌细胞中靶核酸的 表达水平比较，体外预测受试者的预后及/或肾癌转移的有无，其中， 该靶核酸是可通过该组合物、试剂盒或DNA芯片中所含的多核苷酸、 其变异体或其片段检测的核酸，且在确认来自受试者的该靶核酸的表 达水平，与预后良好肾癌患者群体的表达水平及/或预后不良患者群 体的表达水平相比发生变化时，分别确定受试者预后不良、或受试者 预后良好、及/或者确定肾癌转移、或肾癌未转移。
本发明还提供本发明的组合物、试剂盒或DNA芯片在体外检测来 自受试者的生物试样中预测发生了转移的肾癌细胞中的用途。
本发明的上述方法使用下述组合物、试剂盒或DNA芯片，所述组 合物、试剂盒或DNA芯片单独或者以所有可能的组合包含上述说明的 本发明的多核苷酸、其变异体或其片段。
在本发明的肾癌转移的预测、检测或(基因)诊断、及/或肾癌 患者预后的预测中，本发明的组合物、试剂盒或DNA芯片中所含的多 核苷酸、其变异体或其片段，可以作为引物或作为检测探针(探测物) 使用。作为引物使用时，可以举出碱基长度通常为15～50个碱基、优 选15～30个碱基、较优选18～25个碱基的探针。另外，作为检测探针 使用时，例如可以举出碱基长度为15碱基～全部序列的碱基数、优选 25～1000个碱基、较优选25～100个碱基的探针，但并不限定于此范 围。
本发明的组合物或试剂盒中含有的多核苷酸、其变异体或其片 段，在RNA印迹法(Northern Blot)、RT-PCR法、原位杂交法、DNA 杂交法等特异性地检测特定基因的公知方法中，可以根据标准方法用 作引物或探针。作为测定对象试样，根据所用的检测方法的种类，可 以通过活组织检测等采集受试者的肾组织或被怀疑存在肾癌细胞的 生物组织的一部分或全部，或者从手术取出的生物组织中回收。还可 以使用按照常规方法由其制备的总RNA，还可以使用基于该RNA制备 的包括cDNA、聚A(+)RNA在内的各种多核苷酸。
或者，可以使用DNA芯片(包括DNA宏阵列)检测或定量生物组 织中的本发明的基因、RNA、cDNA等核酸的表达量。此种情况下， 本发明的组合物或试剂盒可以用作DNA阵列的探针(例如，在 Affymetrix公司的Human Genome U133 Plus 2.0 Array中，使用长度为 25个碱基的多核苷酸探针)。使上述DNA阵列与以从生物组织采集的 RNA为基础制备的标记DNA或RNA杂交，以该标记DNA或RNA的标 记为指标，检测通过该杂交形成的上述探针和标记DNA或RNA的复合 体，由此能评价生物组织中的肾癌转移及/或肾癌患者预后预测相关基 因是否表达或表达水平(表达量)。本发明方法中优选使用DNA芯片， 该DNA芯片能对一个生物试样同时评价多个基因是否表达或表达水 平。
本发明的组合物、试剂盒或DNA芯片对用于肾癌患者预后预测及 /或转移的预测、确定或检测(是否患病或患病程度的诊断)是有用 的。具体而言，使用该组合物、试剂盒或DNA芯片的肾癌患者预后预 测及/或转移预测可以如下进行：在受试者的存在肾癌细胞的生物组 织中测定用该诊断用组合物能够检测到的基因的表达水平。此时，基 因表达水平不仅包括是否表达的情况，还包括下述情况：在来自预后 良好的患者的存在肾癌细胞的生物组织和来自预后不良的患者的存 在肾癌细胞的生物组织中均表达时，比较两者间的表达量时的差有统 计学意义(p值＜0.05)。例如，由于PABPN1基因在来自预后不良的 患者的肾癌中显示表达诱导/减少，所以在预后不良的受试者的肾癌 组织中表达增加/减少，将该表达量和正常组织的表达量相比较进行 检测时，如果差异显著，则怀疑受试者肾癌转移，并且预测预后不良。
利用本发明的组合物、试剂盒或DNA芯片检测肾癌(细胞)的方 法如下：通过活组织检测等采集或从手术取出的生物组织中回收受试 者的生物组织的一部分或全部，使用选自本发明的多核苷酸组中的1 种或几种多核苷酸、其变异体或其片段检测上述生物组织中含有的基 因，测定该基因的表达量，由此预测肾癌的转移、诊断是否转移或其 程度、及/或预测肾癌患者的预后。另外，本发明的肾癌转移的预测 方法也可以例如对肾癌患者给予用于改善该疾病的治疗药时，检测、 确定或预测该疾病是否改善或改善程度。
本发明的方法，可以包括例如以下(a)、(b)及(c)步骤：
(a)步骤：使来自受试者的生物试样与本发明的组合物、试剂盒 或DNA芯片的多核苷酸接触；
(b)步骤：使用上述多核苷酸作为探针测定生物试样中靶核酸 的表达水平；
(c)步骤：根据(b)的结果，预测肾癌患者的预后、及/或、 确定在该生物试样中是否存在预测发生了转移的肾癌(细胞)。
作为本发明方法中使用的生物试样，可以举出由受试者的生物组 织例如肾组织及其周围组织、怀疑发生肾癌转移的组织等制备的试 样。具体而言，含有由该组织制备的RNA的试样、或含有由该组织制 备的多核苷酸的试样可以如下制备，即，通过活组织检测等采集或从 通过手术取出的生物组织中回收受试者的生物组织的一部分或全部， 然后按照常规方法进行制备。
此处的受试者是指哺乳动物，例如人、猴子、小鼠、大鼠等，并 无限定，优选为人。
本发明的方法，可以根据用作测定对象的生物试样的种类变更步 骤。
作为测定对象物使用RNA时，肾癌(细胞)的检测，可以包括例 如下述步骤(a)、(b)及(c)：
(a)步骤：使由受试者的生物试样制备的RNA或由该RNA转录 的互补多核苷酸(cDNA)与本发明的组合物、试剂盒或DNA芯片的 多核苷酸结合；
(b)步骤：使用上述多核苷酸作为探针，测定与该多核苷酸结 合的来自生物试样的RNA或由该RNA转录的互补多核苷酸；
(c)步骤：根据上述(b)的测定结果，确定是否存在来自预后 不良的患者的肾癌(细胞)。
为了根据本发明检测、确定或诊断发生转移的肾癌(细胞)，例 如可以使用多种杂交法。所述杂交法，例如可以使用RNA印迹法、 DNA印迹法、定量RT-PCR法、DNA芯片分析法、原位杂交法、DNA 杂交法等。
使用RNA印迹法时，通过使用本发明的诊断用组合物作为探针， 可以检测、测定RNA中的各基因是否表达或其表达水平。具体可以举 出以下方法：用放射性同位素(32P、33P、35S等)或荧光物质等标记 本发明的诊断用组合物(互补链)，使其与利用常规方法转移到尼龙 膜等上的来自受试者的生物组织的RNA杂交，然后用放射线检测器 (可以举出BAS-1800II Fuji Photo Film株式会社等)或荧光检测器 (例如STORM860，Amersham Bioscience公司等)检测、测定形成的 诊断用组合物(DNA)和RNA的双链中的来自诊断用组合物的标记物 (放射性同位素或荧光物质)的信号。
使用定量RT-PCR法时，通过使用本发明的上述诊断用组合物作 为引物，可以检测、测定RNA中的基因是否表达或其表达水平。具体 可以举出以下方法：按照常规方法由来自受试者的生物组织的RNA制 备cDNA，为了能以该cDNA为模板扩增各靶基因区域，使由本发明的 诊断用组合物制备的1对引物(由与上述cDNA结合的正链和反链组 成)与cDNA杂交，按照常规方法进行PCR法，检测得到的双链DNA。 作为双链DNA的检测方法，可以采用以下方法：使用预先用放射性同 位素或荧光物质标记的引物进行上述PCR的方法；用琼脂糖凝胶电泳 PCR产物，用溴乙锭等染色双链DNA进行检测的方法；将产生的双链 DNA按照常规方法转移到尼龙膜等上，以标记的诊断用组合物为探针 与其杂交，进行检测的方法。
使用DNA阵列分析时，使用将本发明的上述诊断用组合物作为 DNA探针(单链或双链)结合到基板上制成的DNA芯片。将基因在基 板上固定化得到的物质通常称为DNA芯片及DNA阵列，DNA阵列包 括DNA宏阵列和DNA微阵列，本说明书中称为DNA芯片时，即为含 有该DNA阵列的物质。
杂交条件没有限定，例如，包括在30℃～50℃下，在3～4×SSC、 0.1～0.5％SDS中杂交1～24小时，较优选在40℃～45℃下，在3.4×SSC、 0.3％SDS中杂交1～24小时，然后进行清洗。作为清洗条件，例如可以 举出利用含有2×SSC和0.1％SDS的溶液、及1×SSC溶液、0.2×SSC溶 液在室温下连续清洗等条件。此处，1×SSC是含有150mM氯化钠及 15mM柠檬酸钠的水溶液(pH7.2)。互补链优选为即使在上述条件下 进行清洗仍能保持与作为对象的正链杂交的状态的链。作为上述互补 链，具体可以举出由与作为对象的正链的碱基序列具有完全互补关系 的碱基序列组成的链、以及由与该链具有至少80％同源性的碱基序列 构成的链。
作为以来自本发明的组合物或试剂盒的多核苷酸片段为引物进 行PCR时的严格的杂交条件的例子，例如可以举出使用组成为10mM Tris-HCl(pH8.3)、50mM KCL、1～2mM MgCl2等的PCR缓冲液， 在由该引物序列计算的Tm-5～10℃下处理15秒～1分钟左右等。作为 上述Tm的计算方法，可以举出Tm＝2×(腺嘌呤残基数+胸腺嘧啶残 基数)+4×(鸟嘌呤残基数+胞嘧啶残基数)等。
上述杂交的“严格条件”的其它例子，记载于例如Sambrook，J.& Russel，D.著，Molecular Cloning，A LABORATORY MANUAL、Cold Spring Harbor Laboratory Press、2001年1月15日出版，第1卷7.42～7.45， 第2卷8.9～8.17等中，可以在本发明中使用。
另外，本发明还提供预测肾癌患者的预后的方法、及/或者确定 生物试样中是否含有预测转移的肾癌细胞的方法，该方法使用上述I 组及/或II组中的1种或几种探针、或本发明的组合物、试剂盒、DNA 芯片或它们的组合，测定来自受试者的生物试样中的靶核酸或基因的 表达量，以支持向量机(SVM，support vector machine)作为辨别式 进行判断，所述支持向量机(SVM)以来自预后良好的患者的肾癌组 织中的和来自预后不良的患者的肾癌组织中的基因表达量作为训练 样本。
根据本发明的实施方案，本发明的方法包括以下步骤：第1步骤， 使用本发明的组合物、试剂盒、DNA芯片、或它们的组合，体外测定 多个生物试样中的靶核酸的表达量(也称为表达水平)，所述多个生 物试样是已知来自预后良好的患者的含有肾癌细胞的组织、或来自预 后不良的患者的肾癌细胞的组织；第2步骤，以上述第1步骤得到的该 靶核酸的表达量的测定值为训练样本，制作辨别式(支持向量机)； 第3步骤，与第1步骤相同地体外测定来自受试者的生物试样中的该靶 核酸的表达量；第4步骤，将第3步骤得到的该靶乙酸的表达量的测定 值代入上述第2步骤中所得的辨别式中，根据由该辨别式得到的结果， 预测肾癌患者的预后及/或生物试样中不含预测转移的肾癌细胞、及 /或含有预测转移的肾癌细胞，此处，该靶核酸是能够通过该组合物、 试剂盒或DNA芯片中所含的多核苷酸、其变异体或其片段检测的物 质。
或者，本发明的方法，例如包括下述步骤(a)、(b)及(c)：
(a)步骤：使用本发明的诊断(检测)用组合物、试剂盒或DNA 芯片，测定生物试样中的靶基因的表达量，所述生物试样是已知的来 自预后良好的患者的含有肾癌细胞的组织或来自预后不良的患者的 含有肾癌细胞的组织的试样；
(b)步骤：将(a)测定的表达量的测定值代入下述等式1～5的 式中，制作称为SVM的辨别式；
(c)步骤：使用本发明的诊断(检测)用组合物、试剂盒或DNA 芯片，测定来自受试者的生物试样中的该靶基因的表达量，将其代入 (b)中制作的辨别式中，根据所得的结果，预测肾癌患者的预后、 及/或确定该生物试样中是否含有已转移的肾癌细胞。
SVM是为了解决二级分类问题而制作的，是1995年由AT&T的 V.Vapnik(The Nature of Statistical Leaning Theory、Springer、1995年 出版)基于统计学习理论的框架提出的学习机。SVM是一种线性辨识 器，但通过组合后述的核函数(Kernel)，能够解决非线性问题。针 对不同级别的训练样本，在辨识上述训练样本的多个超平面中，将该 超平面与训练样本的最小距离变得最大的超平面作为辨识面，由此能 最准确地辨识新给予的试样属于哪一个级别。
SVM只能解决线性问题，但作为用于解决本质上为非线性问题的 方法，已知将特征向量非线性地转换成高维，在该高维空间内进行线 性辨识的方法。使用该方法，与在原空间使用非线性模型等效。但进 行向高维转换的绘图需要庞大的计算量，归纳能力也降低。SVM中， 辨识函数仅依赖输入图案的内积，如果能计算内积，则能构建最优辨 识函数。非线性地绘制的空间中的二个要素的内积仅由各自原来的空 间的输入表示的式子称为核函数，一边在高维空间中绘制，一边避免 在实际绘制的空间中的特征的计算，仅由核函数的计算构建最优辨识 函数，即辨别式(“统计科学的前沿6图案识别与学习的统计学”p.107 -138、麻生英树、津田宏治、村田升著、岩波书店、东京、日本、 2003年4月11日出版)。
本发明的方法中能够使用的辨别式的计算例如下所示。
为了确定SVM，可以以生物试样中的靶基因的表达量作为训练样 本，按照以下步骤确定辨识函数的常数，所述生物试样是已知来自预 后良好的患者的含有肾癌细胞的组织或来自预后不良的患者的肾癌 组织的试样。
训练样本xi属于被分类为(+、-)的来自预后良好的患者的含有 肾癌细胞的组织或来自预后不良的患者的肾癌组织中的任一种。可以 用超平面线性分离上述训练样本时，辨识函数例如为下式。
[等式1]
(此处，w表示加权系数、b表示非线性常数(bias constant)、x 表示样本变量。)
但是，该函数存在限制条件：
[等式2]
yi(wTxi+b)≥1-ξi
ξi≥0，i＝1，…，n
(此处，T表示内积、y表示样本的类别、ζ表示松弛变量。)
所以，通过使用拉格朗日(Lagurange)未定乘子法，可以回归到 使用了拉格朗日乘子α的下述最优化问题。
[等式3]
此处，
[等式4]
(此处，C表示通过实验确定的限制条件参数。)
如果解决了该问题，则能够最终得到下式，
[等式5]
从而能毫无疑义地得到辨识函数。通过将新的生物试样(不知道 是否含有肾癌细胞发生了转移的组织的表达基因量)的x代入该函数， 能够分类f(x)(即+或-)，从而判断生物试样属于哪一类(即、 来自预后良好的患者的含有肾癌细胞的组织或来自预后不良的患者 的含有肾癌细胞的组织)。
如上所示，为了制作用于进行未知试样分类的SVM判定式，必需 有二组训练样本。在本发明的情况下，该训练样本例如是以下二组， 即，与“由来自预后良好的肾癌患者的肾癌组织得到的表达基因(基 因x1，x2，..xi，...xn)”的各患者对应的组、以及与“由来自预后不 良的肾癌患者的肾癌组织得到的表达基因(基因x1，x2，..xi，...xn)” 的各患者对应的组。对上述各组分别测定的表达基因数(n)因实验 设计的不同而各种各样，但对于各基因，无论在哪一个实验中，在二 组间都可以观察到存在明显差别的情况和差别比较小或无差别的情 况。为了提高SVM辨别式的精度，要求作为训练样本的二组样本之间 存在显著差异，所以，必须从基因组中仅提取在二组间表达量存在差 别的基因加以利用。
如上所述，作为提取表达量在二组间存在差别的基因的方法，可 以利用作为检测平均值的差的参数分析的t-检验、作为非参数分析的 Mann-Whitney的U检验等。作为利用生存分析法的方法，有采用Log -rank检定或Wilcoxon检定分析通过Kaplan-Meier法绘制的生存曲 线的方法等。另外，生存曲线作为回归模型处理、且用Cox比例风险 模型分析的方法，用于推测某变量是否与生存相关，特别有用。即、 Cox比例风险模型表示，对于采用Kaplan-Meier法对在某范围内分类 的患者组绘制的多个生存曲线，其各变量描述回归模型的充分性。
另外，在本发明的方法中，例如使用选自以上述序列号1～10、 12～20、22～47为基础的1种或几种上述多核苷酸及以上述序列号11、 21、48～50为基础的1种或几种多核苷酸中的任意组合，且上述50种 靶基因的表达量在与来自预后良好的患者的含有肾癌细胞的组织和 来自预后不良的患者的含有肾癌细胞的组织之间均具有显著差异，以 在来自预后不良的患者的含有肾癌细胞的组织中表达变化为指标，测 定上述50种基因的表达量，由此，能以85％以上、89％以上、90％以 上、优选92％以上、较优选93％以上、更优选94％以上的概率，预测 肾癌患者的预后、及/或发现肾癌转移(图2)。
进而，本发明提供一种预测肾癌的预后、或者检测、确定或预测 肾癌转移的方法，该方法使用针对下述多肽的1种或几种抗体或其片 段，体外测定来自预后良好的患者的含有肾癌细胞的组织和来自预后 不良的患者的含有肾癌细胞的组织中该多肽的表达量、或者血液中该 多肽的水平(或存在量)，所述多肽是由上述50种基因(即、与序列 号1～50相当)或其片段(例如、与序列号51～100相当)编码的多肽、 例如由序列号101～150表示的氨基酸序列构成的多肽。
本发明还提供一种检测、确定或预测肾癌的方法，所述方法使用 针对下述多肽的1种或几种、例如2种以上、3种以上、5种以上至全部 的抗体或其片段，体外测定肾癌组织和非癌组织中该多肽的表达量、 或者血液中该多肽的水平(或存在量)，所述多肽是由上述47种多肽 (即、与序列号151～160、191、序列号161～190、192～197相当) 或其片段编码的多肽。
具体而言，上述测定可以通过免疫学方法进行。
作为免疫学测定方法，例如可以举出酶免疫测定法(ELISA、EIA)、 荧光免疫测定法、放射免疫测定法(RIA)、发光免疫测定法、免疫 比浊法、乳胶凝集反应、乳胶比浊法、红细胞凝集反应、颗粒凝集反 应或蛋白质印迹法。
上述方法通过使用了标记的免疫测定法进行时，可以在将本发明 的抗体、或试样中的成分固定化后，进行其免疫学反应。
作为固相载体，可以使用由聚苯乙烯、聚碳酸酯、聚乙烯基甲苯、 聚丙烯、聚乙烯、聚氯乙烯、尼龙、聚甲基丙烯酸酯、乳胶、明胶、 琼脂糖、纤维素、琼脂糖凝胶、玻璃、金属、陶瓷或磁性体等材料组 成的微珠、微量培养板、试管、棒(stick)或试验片等形状的不溶性 载体。
可以通过物理吸附法、化学结合法或并用两种方法等公知的方 法，使固相载体和本发明的抗体或试样成分结合，进行固定化。
本发明中，为了容易地检测本发明的抗体与试样中的靶多肽的反 应，通过标记本发明的抗体直接检测该反应，或通过使用标记二抗间 接检测该反应。本发明的检测方法，从灵敏度方面考虑，优选使用后 者的间接检测(例如，夹心法等)。
作为标记物质，使用酶免疫测定法时，可以使用过氧化物酶 (POD)、碱性磷酸酶、β-半乳糖苷酶、脲酶、过氧化氢酶、葡萄 糖氧化酶、乳酸脱氢酶、淀粉酶或生物素-抗生物素蛋白复合体等； 使用荧光免疫测定法时，可以使用异硫氰酸荧光素、四甲基罗丹明异 硫氰酸盐、取代异硫氰酸罗丹明、二氯三嗪异硫氰酸盐、Alexa或 AlexaFluoro等荧光性物质或荧光团；使用放射免疫测定法时，可以使 用氚、碘(131I，125I，123I，121I)、磷(32P，33P)、硫(35S)、金属 类(例如68Ga，67Ga，68Ge，54Mn，99Mo，99Tc，133Xe等)等放射性同 位素。另外，使用发光免疫测定法时，可以使用NADH-、FMNH2 -、萤光素酶类、鲁米诺-过氧化氢-POD类、吖啶酯类或二氧杂环 丁烷化合物类等。
另外，根据需要，也可以使用抗生物素蛋白-生物素系统或链霉 抗生物素蛋白-生物素系统，此种情况下，例如生物素也可与本发明 的抗体或其片段结合。
作为标记物质和抗体的结合方法，在使用酶免疫测定法时，可以 使用戊二醛法、马来酰亚胺法、吡啶基二硫化物法或高碘酸法等公知 方法；在使用放射免疫测定法时，可以使用氯胺T法、Bolton-Hunter 法等公知方法。测定操作方法可以通过公知的方法(Current protocols in Protein Sciences、1995年，John Wiley & Sons Inc.、Current protocols in Immunology、2001年，John Wiley & Sons Inc.)进行。例如，直接标记 本发明的抗体时，将试样中的成分固定化，使其与标记的本发明的抗 体接触，形成标记多肽和本发明的抗体的复合体。然后将未结合的标 记抗体洗涤分离，可以由结合的标记抗体量或未结合的标记抗体量测 定试样中的靶多肽的量。
另外，使用例如标记二抗时，使本发明的抗体与试样反应(一次 反应)，再与标记二抗反应(二次反应)。一次反应和二次反应可以 以相反的顺序进行，也可以同时进行，还可以错开时间进行。通过一 次反应及二次反应，形成固定化的靶多肽-本发明的抗体-标记二抗 的复合体、或固定化的本发明的抗体-靶多肽-标记二抗的复合体。 然后洗涤分离未结合的标记二抗，可以通过结合的标记二抗量或未结 合的标记二抗量测定试样中的靶多肽的量。
具体而言，使用酶免疫测定法时，在标记酶的最适条件下使其与 底物反应，通过光学方法等测定反应生成物的量。使用荧光免疫测定 法时，测定由荧光物质标记产生的荧光强度，使用放射免疫测定法时， 测定由放射性物质标记产生的放射能量。使用发光免疫测定法时，测 定由发光反应体系产生的发光量。
本发明的方法中，通过采用光学方法测定或者肉眼观测其透射光 或散射光的测定方法来测定免疫比浊法、乳胶凝聚反应、乳胶比浊法、 红细胞凝集反应或颗粒凝集反应等中免疫复合体凝集物的生成，此 时，作为溶剂可以使用磷酸缓冲液、甘氨酸缓冲液、Tris缓冲液或 Good’s缓冲液等，还可以在反应体系中含有聚乙二醇等反应促进剂或 非特异性反应抑制剂。
上述抗体或片段包括多克隆抗体、单克隆抗体、合成抗体、重组 抗体、多特异性抗体(包括双特异性抗体)、单链抗体、Fab片段、F (ab’)2片段等。多克隆抗体可以通过与结合有纯化多肽的亲和柱结 合的所谓吸附法，作为特异性抗体进行制备。
测定方法可以包括以下步骤：使被惯用的酶或荧光团标记的抗体 或片段与组织切片或匀浆化的组织或者体液(例如血液、血清、血浆、 尿等)接触的步骤、定性或定量测定抗原-抗体复合体的步骤。可以 通过以下方法进行检测：例如，利用免疫电子显微镜测定靶多肽的存 在和水平的方法、利用ELISA或荧光抗体法等惯用方法测定靶多肽的 水平的方法等，由此，不仅能够检测肾癌，而且在来自预后良好的患 者的含有肾癌细胞的组织或来自预后不良的患者的肾癌组织中的靶 多肽的表达量减少时，或者与来自预后良好的患者的患有肾癌的受试 者相比，来自预后不良的患者的患有肾癌的受试者血液中该多肽的水 平显著变化时，能够确定预后不良、及/或肾癌转移。换言之，上述 多肽的表达量或水平，与正常值相比具有显著变化时，可以诊断为肾 癌、或者、确定预后不良及/或为已发生转移的肾癌。此处，所谓显 著是指有统计学意义。
实施例
通过以下实施例进一步具体地说明本发明。但是，本发明的范围 并不限定于这些实施例。
<实施例1>
(1)实验者的临床病理学观察
从取得知情同意的进行肾癌切除手术的31名日本肾癌患者得到 组织。对切除的组织片进行肉眼及/或病理组织学观察，判断肾癌组织 后立即冷冻，于液氮中保存。
(2)总RNA提取和cDNA的制备
作为试样，使用肾癌患者的肾组织中肾癌病变部的组织。使用 Trizol试剂(Invitrogen社)，按照该公司推荐的操作手册，由各组织 制备总RNA。
并用寡聚(dT)引物及随机九聚物，使用CyScribe First-Strand cDNA Labeling试剂盒(GE Healthcare公司，日本)，按照制造商推 荐的操作手册，对由上述方法得到的总RNA 1μg进行逆转录反应。在 来自肾癌组织的总RNA中添加Cy3-dUTP(GE Healthcare公司)，在 参考总RNA(Stratagene公司)中添加Cy5-dUTP(GE Healthcare公 司)，按照制造商推荐的操作手册，在逆转录反应时进行cDNA的标 记。被标记的cDNA用QIA quick PCR纯化试剂盒(QIAGEN公司)纯 化后用于杂交。
(3)寡DNA微阵列的制作
作为寡DNA微阵列，使用根据Affymetrix公司GeneChipTM(Human Genome U133A)及本说明书中记载的方法制作的DNA芯片。
DNA芯片的制作方法如下所示。为了确定最初载带的寡DNA的种 类，使用Affymetrix公司的GeneChipTM，进行基因的确定。GeneChipTM 的操作基于Complete GeneChipTM Instrument System等该公司规定的 顺序进行。使用Complete GeneChipTM的分析结果是提取得到有可能因 肾癌导致表达变化的基因及可以作为实验对照的基因，共计8961种。
对于提取的8961种基因，为了不引起序列的重复，分别选择序列 特异性高的位点处的含60-70个残基的序列进行合成。在 MATSUNAMI·DNA微阵列用涂层玻璃的耐DMSO的I型氨基修饰寡 DNA固定涂层(松浪硝子工业株式会社，日本)上，使用点样仪 (spotter)(GMS417 arrayer，Affymetrix公司)，在50-60％湿度环 境中点样合成寡DNA，所述合成寡DNA溶解在稀释至4倍的溶液I (TakaraBio公司，日本)中，浓度为30μM，含有序列号21-40的寡 DNA、并由8961种的60或70mer组成。
(4)杂交
在反义寡聚混合物(cocktail)(QIAGEN公司)中溶解1μg标记 的cDNA，将得到的溶液排列到载有被覆Gap的玻璃(松浪硝子工业公 司)的DNA芯片上，在42℃下杂交16小时。杂交结束后，依次用2× SSC/0.1％SDS、1×SSC、0.2×SSC清洗DNA芯片。
(5)基因表达量的测定
使用Agilent微阵列扫描仪(Agilent公司)扫描利用上述方法进行 杂交的DNA芯片，获得图像，将荧光强度转变为数值。参考Speed T. 著“Statistical analysis of gene expression microarray data”Chapman &Hall/CRC、及Causton H.C.等著“A beginner’s guide Microarray gene expression data analysis” Blackwell publishing进行统计学处理。即， 将从杂交后的图像分析得到的数据分别取对数值，进行整体最佳化 (global normalization)，并根据LOWESS(局部加权回归散点修匀 法(locally weighted scatterplot smoother))进行平滑化，通过MAD 缩放处理，进行数值校正。
(6)预测评分系统
此处，研究全部患者的各种临床信息，进行生存分析，探讨临床 信息不同是否会导致生存年数的差异。作为其一例如下，分成两组， 即手术时诊断出已转移至肾脏以外器官的患者组和未诊断出发生转 移的患者组，对各组进行生存分析，采用Kaplan-Meier法作图(图1)。 此时，在于手术时诊断出已转移至肾脏以外器官的患者组和未诊断出 发生转移的患者组间，采用使用Log-rank法的检定可见生存曲线具 有显著差异(p＜0.05)。此结果表明，两患者组的预后不同，诊断出 发生转移的患者的预后较差，未诊断出发生转移的患者的预后良好。 因此，进一步通过Cox比例风险模型法探讨各表达基因对按是否转移 分类的患者组的预后、即对生存曲线模型的影响，探讨基因表达量和 生存曲线的适合度的显著性。结果，以术后的生存曲线为指标，可以 得到321种对生存显著有利的表达基因、164种对生存不利的表达基因 (上述表1)。因此，利用上述基因，能够检测肾癌患者的预后、及 /或肾癌是否转移。
使用上述基因，制作使用搭载在Genomic Profiler(三井信息开发、 日本)上的SVM的辨别式。根据此辨别式，对全部31例的数据进行数 据预测。以全部检体为对象进行分析，以手术后5年时间内的生存为 指标，比较来自预后良好的患者的肾癌病变部和来自预后不良的患者 的肾癌病变部，使用认为有利于生存的排序高的表达基因的数据进行 分析，此时，通过分析使用序列号1～19及48的多核苷酸测定的基因 表达，能够以96％以上的概率预测预后良好的患者(图2)。
另一方面，以全部检体为对象进行分析，以手术后5年内的生存 为指标，比较来自预后良好的患者的肾癌病变部和来自预后不良的患 者的肾癌病变部，使用认为不利于生存的排序高的表达基因的数据进 行分析，此时，通过分析使用序列号20～47、49及50的多核苷酸测定 的基因表达，由此能够以87％以上的概率预测预后不良的患者(图2)。
需要说明的是，除上述使用的探针以外的本发明的其它探针也可 以同样地用于肾癌患者预后的预测。
在上述预后的确定中，同时针对1个受试组织的基因表达量套用 上述2个识别来自预后良好的患者的肾癌组织的SVM和识别来自预后 不良的患者的肾癌组织的SVM，进行分析。
结果，针对某一受试组织，当2个识别式同时得到为来自预后良 好的患者的肾癌组织的结果时、或当2个识别式同时得到为来自预后 不良的患者的肾癌组织的结果时，各诊断的准确度显著高于根据现有 的通过1个辨别式进行诊断的方法。
<实施例2>
(1)健康人及肾癌患者血浆的蛋白质鉴定
在肾癌切除手术前、及肾癌切除手术1个月后的健康状态下，由5 名50～70岁日本肾癌患者分别得到添加EDTA的血浆成分。
用孔径0.22μm的过滤器过滤血浆，除去杂质物质，进行调整，使 蛋白质浓度为50mg/mL。进一步将该血浆注入到25mM碳酸氢铵溶液 (pH8.0)中进行稀释，使浓度为12.5mg/mL，用中空纤维过滤器(东 丽，日本)进行分子量截留。用ProteomeLab(注册商标)PF2D System (Beckman Coulter公司)反相色谱将截留后的血浆样品(总量1.8mL、 含有最多250μg的蛋白质)分离成7个馏分，冻干后，再溶解于100μL 25mM碳酸氢铵溶液(pH8.0)。将该样品用蛋白质的五十分之一的量 的胰蛋白酶在37℃下消化2～3小时，进行肽化。再利用离子交换柱 (KYA Technologies，日本)将各馏分的肽分离成4个馏分。
将上述各馏分进一步用反相柱(KYA Technologies)分馏，用在 线连接的质谱Q-TOF Ultima(Micromass公司)，通过分析扫描模式 (survey scan mode)对洗脱的肽进行测定。通过用蛋白质鉴定软件 MASCOT(Matrix Science)分析上述测定数据，进行彻底的蛋白质鉴 定。结果从手术前、手术后的所有血浆成分中，均能够鉴定到MASCOT 分数在40以上(鉴定肽数2个以上)的约3500种蛋白质。
(2)肾癌患者的肾癌切除手术前及手术后的血浆蛋白质表达比 较
在肾癌切除手术前及手术后，对上述实施例2(1)中鉴定的血浆 蛋白质进行比较。找到了手术后未检测到表达、手术前在6名中有4名 以上检测到表达的蛋白质。上述蛋白质为上述表2所示的序列号151～ 160、191表示的多肽，表明其作为所谓肾癌标记物在肾癌的检测中有 用。在各患者中的表达频率如表2所示。在接受肾癌切除手术前的患 者中，6名中有4名以上能够检测到表达(以+表示)(表4)。
所以，可以通过使用例如上述多肽中的至少1种的特异抗体测定 该多肽的存在或量来检测肾癌。
[表4]
序列号 蛋白质序号 基因名 患者1 患者2 患者3 患者4 患者5 患者6 151 P54646 AAK2 - + + + + + 152 Q8IW52 SLK4 - - + + + + 153 Q8TC36 SP4L - + - + + + 154 Q96SZ6 C5P1 + - + + - + 155 Q16739 CEGT + + + + - - 156 Q92185 SI8A + + - - + + 157 P13861 KAP2 + + - + - + 158 O60825 F262 + + - + + - 159 Q99832 TCPH - + + - + + 160 P29992 GB11 + - + + + 191 Q9H423 CT67 + - + - + +
<实施例3>
(1)健康人及肾癌患者血浆的蛋白质鉴定
在肾癌切除手术前、及肾癌切除手术1个月后的健康状态下由7名 50～70岁日本肾癌患者分别获取添加EDTA的血浆成分。
用孔径0.22μm的过滤器过滤血浆，除去杂质物质，进行调整，使 蛋白质浓度为50mg/mL。进一步将该血浆注入到25mM碳酸氢铵溶液 (pH8.0)中进行稀释，使浓度为12.5mg/mL，用中空纤维过滤器(东 丽，日本)进行分子量截留。用ProteomeLab(注册商标)PF2D System (Beckman Coulter公司)反相色谱将截留后的血浆样品(总量1.8mL、 含有最多250μg的蛋白质)分离成7个馏分，冻干后，再溶解于100μL 25mM碳酸氢铵溶液(pH8.0)。将该样品用蛋白质的五十分之一的量 的胰蛋白酶在37℃下消化2～3小时，进行肽化。再利用离子交换柱 (KYA Technologies，日本)将各馏分的肽分离成4个馏分。
将上述各馏分进一步用反相柱(KYA Technologies)分馏，用在 线连接的质谱Q-TOF Ultima(Micromass公司)，通过分析扫描模式 (survey scan mode)对洗脱的肽进行测定。通过用蛋白质鉴定软件 MASCOT(Matrix Science)分析上述测定数据，进行彻底的蛋白质鉴 定。结果从手术前、手术后的所有血浆成分中，均能够鉴定到MASCOT 分数在40以上(鉴定肽数2个以上)的约3500种蛋白质。
(2)肾癌患者在肾癌切除手术前及手术后的血浆蛋白质表达比 较
在肾癌切除手术前及手术后之间，对上述实施例3(1)中鉴定的 血浆蛋白质进行比较。找到手术后未检测到表达、手术前在7名中有3 名以上检测到表达的蛋白质。上述蛋白质为上述表1所示的序列号 161～182、192、193表示的多肽，表明其作为所谓肾癌标记物在肾癌 的检测中有用。各患者中的表达频率如表5所示。在接受肾癌切除手 术前的患者中，7名中有3名以上检测到上述蛋白质的表达(以+表 示)。
所以，可以针对上述多肽的至少1种、优选至少3～5种，例如通 过使用其特异抗体，测定该多肽的存在或量来检测肾癌。
[表5]
序列号 蛋白质序号 基因名 患者 1 患者 2 患者 3 患者 4 患者 5 患者 6 患者 7 161 Q16671 AMHR2 - - + + - + - 162 O95236 APOL3 + - + - - + - 163 Q8WXF8 DEDD2 - - - + + + - 164 P07686 HEXB + - - + - - + 165 P61978 HNRPK - - + + + - - 166 P52294 KPNA1 - - + + - - + 167 Q14847 LASP1 - + - - + + - 168 O43766 LIAS - - + - + + - 169 Q8TD91 MAGEC3 - + - + - - + 170 Q14934 NFATC4 + + + - - - - 171 Q96PB7 OLFM3 + - - + - - + 172 Q9H1D9 POLR3F + - + - + - - 173 NP_066955 PPP3CB + - - - - + + 174 Q15637 SF1 + + - - - - + 175 Q9UI40 SLC24A2 + + + - - - - 176 O43511 SLC26A4 + + - + - - - 177 P46721 SLCO1A2 - + - + + - + 178 P07951 TPM2 - - - + + + - 179 Q9Y5K5 UCHL5 - + + - + - - 180 Q16880 UGT8 + + - - + - - 181 P52738 ZNF140 + - + - - - + 182 Q96GC6 ZNF274 + + + + - - - 192 P08253 MMP2 - + - + + + - 193 P26842 TNFRSF7 + + - + - + -
(3)肾癌患者在肾癌切除手术前及手术后的血浆蛋白质表达比较
分别在肾癌切除手术前及手术后比较7名患者的上述(1)中鉴定 的血浆蛋白质。在各个人中找到与同一人相比在手术后未检测到表 达、手术前检测到表达的肾癌特异性蛋白质。其中，在7名患者中的5 名中共同发现的蛋白质如表6所示。上述蛋白质为上述表6所示的序列 号183～190、194～197表示的多肽，表明其作为所谓肾癌标记物在肾 癌的检测中有用。
[表6]
序列号 蛋白质序号 基因名 患者 1 患者 2 患者 3 患者 4 患者 5 患者 6 患者 7 183 Q9UJV3 MID2 + + + + - - + 184 Q05469 LIPE + + - + - + + 185 Q9UBN7 HDAC6 - + + + + + + 186 Q99798 ACO2 + + + - + - + 187 P51693 APLP1 + - + + - + + 188 P49757 NUMB + + + + - + - 189 Q14155 ARHGEF7 + - - + + + + 190 P50148 GNAQ + - - + + + + 194 O95263 PDE8B - + + + + + - 195 O75955 FLOT1 + + - + + + + 196 P06127 CD5 + + + - + + - 197 Q16610 ECM1 + + - + + + -
产业上的可利用性
根据本发明，能够提供特异性、灵敏度优良的用于肾癌的检测、 诊断、转移预测及/或肾癌患者预后预测的组合物、试剂盒、DNA芯 片、及方法，因此，本发明特别是在制药及医药产业中是有用的。
专利文献1：国际公开第2005/024603号说明书
专利文献2：国际公开第2004/042077号说明书
专利文献3：国际公开第2004/048933号说明书
专利文献4：美国专利第6303765号说明书
专利文献5：特表2005-520536
专利文献6：特表2005-507997
专利文献7：国际公开第2002/06339号说明书
专利文献8：特表2004-518402
非专利文献1：Latif，F.等，Science、1993年、第260卷、p.1317 -1320
非专利文献2：Maxwell，P.等，Nature、1999年、第399卷、p.271 -275
非专利文献3：Lein，M.等，International Journal of Cancer、2000 年、第85卷、p.801-804
非专利文献4：Nakatsuji，T.、Clinical and Experimental Medicine、 2003年、第2卷、p.192-196
非专利文献5：Nagase，Y.等，日本泌尿器科学会杂志、1991年、 第82卷、p.1781-1789
非专利文献6：Miyake，H.等，1996年、Cancer Research、第56 卷、p.2440-2445
非专利文献7：Kitagawa，Y.等，1999年、Journal of Urology、第 162卷、p.905-909
非专利文献8：Freeman，M.R.等，1989年、Cancer Research、第 49卷、p.6221-6225
序列表
<110>东丽株式会社
国立大学法人京都大学
<120>用于肾癌诊断、肾癌患者预后预测的组合物及方法
<130>PH-2870-PCT
<140>PCT/JP2006/317380
<141>2006-09-01
<150>JP 2005-255499
<151>2005-09-02
<150>JP 2005-318589
<151>2005-11-01
<160>197
<170>PatentIn version 3.1
<210>1
<211>3072
<212>DNA
<213>人
<400>1
aatgaaggtg gacacccaaa tagccccaat acaaatgcct gttcaatcaa ccaaacatct 60
agcagcaca tctatgtggt agcatattgc caggccgtga gactgcgaat ataaatagga 120
accgcccctc atctgcaggc gctcacaacc tagttagcaa acagtaaaac aattaagcgc 180
gccgtggaca taggcccact tgtcctggga aatgagggga agctggggtt tgcagtggtt 240
tgattgaagg gggactacat gttagaggca cagactgggt gcaggtacac ccaaaggaac 300
gagaagagtg gaaggaaaca acatccacaa agtaaccaca tgctggcgta tcgaaggccg 360
tgatttacgg ttttgagact ttacctcgcc agcaaagggg ggccagtctg ttagcggtgc 420
agattggagg ggtgacattg gaagctgtcc aggaaaaaga aaatggaact ggggagcaga 480
aggcctacgc aagagggcgg gacagacagg acttgtgact agtagctctg gactgaggaa 540
tcctccctgc tttctggtgc gggagagcta gtggatgatg gtgccaataa cctggatggg 600
gaaagtaagc tccctcctgg aatgcttcat tcacaacctc cattttcagc aacatcccat 660
ctactggtgc ttcctggtcg agatacaagt ttcctgaaac tgctgctctg ttttgggcct 720
cacccggcca acagctcact agctggcaag cagtagtatc aagatggcgg ccccctagga 780
ctggctagtc atgtgacctc gggtttccca agtttgaagc ccggcagtcc tttcgggggc 840
aaggttcacc tgtcacgaaa cgagtgtcac cccttcgact ctcgcaagcc aatcggcatc 900
tgagactggg ccactgcggt gaggcgatcg gaagattggt cctttccagt cgcctagcta 960
gggccaatca cggagcgtcc catacttcgc gggcccgccc gtaggccggg gagaagcagg 1020
aatatcgtca cagcgtggcg gtattattac ctaaggactc gataggaggt gggacgcgtg 1080
ttgattgaca ggcagatttc cctaccggga tttgagaatt tggcgcagtg cccgccttag 1140
aggtgcgctt atttgattgc caagtaatat tccccaatgg agtactagct catggtgacg 1200
caggcagc ttgagctaat gagtcctccg tggccggcgc agctctccac atgccgggcg 1260
gcgggcccca gtctgagcgg cgatggcggc ggcggcggcg gcggcagcag cagcgggggc 1320
tgcgggcggt cggggctccg ggccggggcg gcggcgccat cttgtgcccg gggccggtgg 1380
ggaggccggg gagggggccc cggggggcgc aggggactac gggaacggcc tggagtctga 1440
ggaactggag cctgaggagc tgctgctgga gcccgagccg gagcccgagc ccgaagagga 1500
gccgccccgg ccccgcgccc ccccgggagc tccgggccct gggcctggtt cgggagcccc 1560
cggcagccaa gaggaggagg aggagccggg actggtcgag ggtgacccgg gggacggcgc 1620
cattgaggac ccggagctgg aagctatcaa agctcgagtc agggagatgg aggaagaagc 1680
tgagaagcta aaggagctac agaacgaggt agagaagcag atgaatatga gtccacctcc 1740
aggcaatgct ggcccggtga tcatgtccat tgaggagaag atggaggctg atgcccgttc 1800
atctatgtt ggcaatgtgg actatggtgc aacagcagaa gagctggaag ctcactttca 1860
tggctgtggt tcagtcaacc gtgttaccat actgtgtgac aaatttagtg gccatcccaa 1920
agggtttgcg tatatagagt tctcagacaa agagtcagtg aggacttcct tggccttaga 1980
tgagtcccta tttagaggaa ggcaaatcaa ggtgatccca aaacgaacca acagaccagg 2040
catcagcaca acagaccggg gttttccacg agcccgctac cgcgcccgga ccaccaacta 2100
caacagctcc cgctctcgat tctacagtgg ttttaacagc aggccccggg gtcgcgtcta 2160
caggggccgg gctagagcga catcatggta ttccccttac taaaaaaagt gtgtattagg 2220
aggagagaga ggaaaaaaag aggaaagaag gaaaaaaaaa agaattaaaa aaaaaaaaaa 2280
gaaaaacaga agatgacctt gatggaaaaa aaatattttt taaaaaaaag atatactgtg 2340
gaagggggga gaatcccata actaactgct gaggagggac ctgctttggg gagtagggga 2400
aggcccaggg agtggggcag ggggctgctt attcactctg gggattcgcc atggacacgt 2460
ctcaactgcg caagctgctt gcccatgttt ccctgccccc ttcaccccct tgggcctgct 2520
caagggtagg tgggcgtggg tggtaggagg gtttttttta cccagggctc tggaaggaca 2580
ccaaactgtt ctgcttgtta ccttccctcc cgtcttctcc tcgcctttca cagtcccctc 2640
ctgcctgctc ctgtccagcc aggtctacca cccaccccac ccctctttct ccggctccct 2700
gcccctccag attgcctggt gatctatttt gtttcctttt gtgtttcttt ttctgttttg 2760
agtgtctttc tttgcaggtt tctgtagccg gaagatctcc gttccgctcc cagcggctcc 2820
agtgtaaatt ccccttcccc ctggggaaat gcactacctt gttttggggg gtttaggggt 2880
gtttttgttt ttcagttgtt ttgttttttt gttttttttt tttcctttgc cttttttccc 2940
ttatttgg agggaatggg aggaagtggg aacagggagg tgggaggtgg attttgttta 3000
tttttttagc tcatttccag gggtgggaat ttttttttaa tatgtgtcat gaataaagtt 3060
gtttttgaaa at 3072
<210>2
<211>2658
<212>DNA
<213>人
<400>2
cgcagaggca ccgccccaag tttgttgtga ccggcggggg acgccggtgg tggcggcagc 60
gcggctgcg ggggcaccgg gccgcggcgc caccatggcg gtgcgacagg cgctgggccg 120
cggcctgcag ctgggtcgag cgctgctgct gcgcttcacg ggcaagcccg gccgggccta 180
cggcttgggg cggccgggcc cggcggcggg ctgtgtccgc ggggagcgtc caggctgggc 240
cgcaggaccg ggcgcggagc ctcgcagggt cgggctcggg ctccctaacc gtctccgctt 300
cttccgccag tcggtggccg ggctggcggc gcggttgcag cggcagttcg tggtgcgggc 360
ctggggctgc gcgggccctt gcggccgggc agtctttctg gccttcgggc tagggctggg 420
cctcatcgag gaaaaacagg cggagagccg gcgggcggtc tcggcctgtc aggagatcca 480
ggcaattttt acccagaaaa gcaagccggg gcctgacccg ttggacacga gacgcttgca 540
gggctttcgg ctggaggagt atctgatagg gcagtccatt ggtaagggct gcagtgctgc 600
tgtgtatgaa gccaccatgc ctacattgcc ccagaacctg gaggtgacaa agagcaccgg 660
gttgcttcca gggagaggcc caggtaccag tgcaccagga gaagggcagg agcgagctcc 720
gggggcccct gccttcccct tggccatcaa gatgatgtgg aacatctcgg caggttcctc 780
cagcgaagcc atcttgaaca caatgagcca ggagctggtc ccagcgagcc gagtggcctt 840
ggctggggag tatggagcag tcacttacag aaaatccaag agaggtccca agcaactagc 900
ccctcacccc aacatcatcc gggttctccg cgccttcacc tcttccgtgc cgctgctgcc 960
aggggccctg gtcgactacc ctgatgtgct gccctcacgc ctccaccctg aaggcctggg 1020
ccatggccgg acgctgttcc tcgttatgaa gaactatccc tgtaccctgc gccagtacct 1080
ttgtgtgaac acacccagcc cccgcctcgc cgccatgatg ctgctgcagc tgctggaagg 1140
cgtggaccat ctggttcaac agggcatcgc gcacagagac ctgaaatccg acaacatcct 1200
tggagctg gacccagacg gctgcccctg gctggtgatc gcagattttg gctgctgcct 1260
ggctgatgag agcatcggcc tgcagttgcc cttcagcagc tggtacgtgg atcggggcgg 1320
aaacggctgt ctgatggccc cagaggtgtc cacggcccgt cctggcccca gggcagtgat 1380
tgactacagc aaggctgatg cctgggcagt gggagccatc gcctatgaaa tcttcgggct 1440
tgtcaatccc ttctacggcc agggcaaggc ccaccttgaa agccgcagct accaagaggc 1500
tcagctacct gcactgcccg agtcagtgcc tccagacgtg agacagttgg tgagggcact 1560
gctccagcga gaggccagca agagaccatc tgcccgagta gccgcaaatg tgcttcatct 1620
aagcctctgg ggtgaacata ttctagccct gaagaatctg aagttagaca agatggttgg 1680
ctggctcctc caacaatcgg ccgccacttt gttggccaac aggctcacag agaagtgttg 1740
tgtggaaaca aaaatgaaga tgctctttct ggctaacctg gagtgtgaaa cgctctgcca 1800
ggcagccctc ctcctctgct catggagggc agccctgtga tgtccctgca tggagctggt 1860
gaattactaa aagaacttgg catcctctgt gtcgtgatgg tctgtgaatg gtgagggtgg 1920
gagtcaggag acaagacagc gcagagaggg ctggttagcc ggaaaaggcc tcgggcttgg 1980
caaatggaag aacttgagtg agagttcagt ctgcagtcct gtgctcacag acatctgaaa 2040
agtgaatggc caagctggtc tagtagatga ggctggactg aggaggggta ggcctgcatc 2100
cacagagagg atccaggcca aggcactggc tgtcagtggc agagtttggc tgtgaccttt 2160
gcccctaaca cgaggaactc gtttgaaggg ggcagcgtag catgtctgat ttgccacctg 2220
gatgaaggca gacatcaaca tgggtcagca cgttcagtta cgggagtggg aaattacatg 2280
aggcctgggc ctctgcgttc ccaagctgtg cgttctggac cagctactga attattaatc 2340
tcacttagcg aaagtgacgg atgagcagta agtaagtaag tgtggggatt taaacttgag 2400
ggtttccctc ctgactagcc tctcttacag gaattgtgaa atattaaatg caaatttaca 2460
actgcagatg acgtatgtgc cttgaactga atatttggct ttaagaatga ttcttatact 2520
ctgaaggtga gaatattttg tgggcaggta tcaacattgg ggaagagatt tcatgtctaa 2580
ctaactaact ttatacatga tttttaggaa gctatgccta aatcagcgtc aacatgcagt 2640
aaaggttgtc ttcaactg 2658
<210>3
<211>604
<212>DNA
<213>人
<400>3
atgcattctg caagccaccc tggggtgcag ctgagctaga catgggacgg cgagacgccc 60
agctcctggc agcgctcctc gtcctggggc tatgtgccct ggcggggagt gagaaaccct 120
ccccctgcca gtgctccagg ctgagccccc ataacaggac gaactgcggc ttccctggaa 180
tcaccagtga ccagtgtttt gacaatggat gctgtttcga ctccagtgtc actggggtcc 240
cctggtgttt ccaccccctc ccaaagcaag agtcggatca gtgcgtcatg gaggtctcag 300
accgaagaaa ctgtggctac ccgggcatca gccccgagga atgcgcctct cggaagtgct 360
gcttctccaa cttcatcttt gaagtgccct ggtgcttctt cccgaagtct gtggaagact 420
gccattacta agagaggctg gttccagagg atgcatctgg ctcaccgggt gttccgaaac 480
aaagaagaa acttcgcctt atcagcttca tacttcatga aatcctgggt tttcttaacc 540
atcttttcct cattttcaat ggtttaacat ataatttctt taaataaaac ccttaaaatc 600
tgct 604
<210>4
<211>2977
<212>DNA
<213>人
<400>4
gggagagtcg gaagcgcggc ggccgcggag ccctgcgagt aggcagcgtt gggcccatgc 60
aggacgcgga gaacgtggcg gtgcccgagg cggccgagga gcgcgccgag cccggccagc 120
agcagccggc cgccgagccg ccgccagccg aggggctgct gcggcccgcg gggcccggcg 180
ctccggaggc cgcggggacc gaggcctcca gtgaggaggt ggggatcgcg gaggccgggc 240
cggagtccga ggtgaggacc gagccggcgg ccgaggcaga ggcggcctcc ggcccgtccg 300
agtcgccctc gccgccggcc gccgaggagc tgcccgggtc gcatgctgag ccccctgtcc 360
cggcacaggg cgaggcccca ggagagcagg ctcgggacga gcgctccgac agccgggccc 420
aggcggtgtc cgaggacgcg ggaggaaacg agggcagagc ggccgaggcc gaaccccggg 480
cgctggagaa cggcgacgcg gacgagccct ccttcagcga ccccgaggac ttcgtggacg 540
acgtgagcga ggaagaatta ctgggagatg tactcaaaga tcggccccag gaagcagatg 600
gaatcgattc ggtgattgta gtggacaatg tccctcaggt gggacccgac cgacttgaga 660
ctcaaaaa tgtcatccac aagatctttt ccaagtttgg gaaaatcaca aatgattttt 720
atcctgaaga ggatgggaag acaaaagggt atattttcct ggagtacgcg tcccctgccc 780
acgctgtgga tgctgtgaag aacgccgacg gctacaagct tgacaagcag cacacattcc 840
gggtcaacct ctttacggat tttgacaagt atatgacgat cagtgacgag tgggatattc 900
cagagaaaca gcctttcaaa gacctgggga acttacgtta ctggcttgaa gaggcagaat 960
gcagagatca gtacagtgtg atttttgaga gtggagaccg cacttccata ttctggaatg 1020
acgtaaaaga ccctgtctca attgaagaaa gagcgagatg gacagagacg tatgtgcgtt 1080
ggtctcctaa gggcacctac ctggctacct ttcatcaaag aggcattgct ctatgggggg 1140
gagagaaatt caagcaaatt cagagattca gccaccaagg ggttcagctt attgacttct 1200
caccttgtga aaggtacctg gtgaccttta gccccctgat ggacacgcag gatgaccctc 1260
aggccataat catctgggac atccttacgg ggcacaagaa gaggggtttt cactgtgaga 1320
gctcagccca ttggcctatt tttaagtgga gccatgatgg caaattcttt gccagaatga 1380
ccctggatac gcttagcatc tatgaaactc cttctatggg tcttttggac aagaagagtt 1440
tgaagatctc tgggataaaa gacttttctt ggtctcctgg tggtaacata atcgccttct 1500
gggtgcctga agacaaagat attccagcca gggtaaccct gatgcagctc cctaccaggc 1560
aagagatccg agtgaggaac ctgttcaatg tggtggactg caagctccat tggcagaaga 1620
acggagacta cttgtgtgtg aaagtagata ggactccgaa aggcacccag ggtgttgtca 1680
caaattttga aattttccga atgagggaga aacaggtacc tgtggatgtg gtcgagatga 1740
aagaaaccat catagccttt gcctgggaac caaatggaag taagtttgct gtgctgcacg 1800
gagaggctcc gcggatatct gtgtctttct accacgtcaa aaacaacggg aagattgaac 1860
tcatcaagat gttcgacaag cagcaggcga acaccatctt ctggagcccc caaggacagt 1920
tcgtggtgtt ggcgggcctg aggagtatga acggtgcctt agcgtttgtg gacacttcgg 1980
actgcacggt catgaacatc gcagagcact acatggcttc cgacgtcgaa tgggatccta 2040
ctgggcgcta cgtcgtcacc tctgtgtcct ggtggagcca taaggtggac aacgcgtact 2100
ggctgtggac tttccaggga cgcctcctgc agaagaacaa caaggaccgc ttctgccagc 2160
tgctgtggcg gccccggcct cccacactcc tgagccagga acagatcaag caaattaaaa 2220
aggatctgaa gaaatactct aagatctttg aacagaagga tcgtttgagt cagtccaaag 2280
cctcaaagga attggtggag agaaggcgca ccatgatgga agatttccgg aagtaccgga 2340
aaatggccca ggagctctat atggagcaga aaaacgagcg cctggagttg cgaggagggg 2400
gacactga cgagctggac agcaacgtgg acgactggga agaggagacc attgagttct 2460
tcgtcactga agaaatcatt cccctcggga atcaggagtg acctggagca ctgtgcgcag 2520
ccgtgtgtgc tgtggagccg aggccgtcct gcaggaagcc gcgtgactcc cgcctcctcc 2580
ctgtgctctc tggctctgga ctgtgactgc gcctggattc tgccattgcg acacattttt 2640
gtgcctttca gcccctggtg tctgcagtgg gggatttaag gcacccgctt ccacttcttt 2700
cttgtttgga gttttctgtt ggaaccgccg gcgttggctc cgaagactta gcgacgccac 2760
tggcggcacc ttctcctgcg cccagtgatg tttccacggt gcctgtacac agccgagcag 2820
catttccgtt gaaggacttg catccccatt gcgggcagtg ctggacgtgt cccggagacc 2880
caccgggagg gcgccgccat gccttgtacc cccaccgtgc aggttgtggc cggttttctc 2940
caggttga acatggaaat aaaagcaaac ttgtatg 2977
<210>5
<211>2002
<212>DNA
<213>人
<400>5
ggtggttctt gcccgtgttg tgtgtgtgtg tgagtgagag agcgagtgag tgagtgagtg 60
agtgtgtgtg tgggggggac tcggcttgtt gttgtcggtg acttccccct ccccttcacc 120
ccttcccctc cccgccgccg ctgcagtggc cgctccctgg gccgtaggaa atgagcgata 180
acgatgacat cgaggtggag agcgacgaag agcaaccgag gtttcaatct gcggctgaca 240
aacgggctca tcataatgca ctggaacgaa aacgtaggga ccacatcaaa gacagctttc 300
acagtttgcg ggactcagtc ccatcactcc aaggagagaa ggcatcccgg gcccaaatcc 360
tagacaaagc cacagaatat atccagtata tgcgaaggaa aaaccacaca caccagcaag 420
atattgacga cctcaagcgg cagaatgctc ttctggagca gcaagtccgt gcactggaga 480
aggcgaggtc aagtgcccaa ctgcagacca actacccctc ctcagacaac agcctctaca 540
ccaacgccaa gggcagcacc atctctgcct tcgatggggg ctcggactcc agctcggagt 600
ctgagcctga agagccccaa agcaggaaga agctccggat ggaggccagc taagccactc 660
ggggcaggcc agcaataaaa actgtctgtc tccatcgtct catcctcctt tcagttcgtt 720
ggtagagccc tcagaaccat ttaagagact ctttattttt ctctttctcc cttttttttt 780
aattttta tttttacgta gaagctcttg gacaacagct ctcgttctcc ttccccattt 840
ccactgtata ttttttaatg tattcccttc agggattccc tgtccccaac aggaattttt 900
aaaccaaaac accccaactt ggcagctttt tctgtggagg acagacggcc ggccggacct 960
ctgagcacat agtgtcctgc ccaccctacc agctcctcca gccctgccgg gcacatgccc 1020
gggggacgcc tgccctgccc aggtggcctc ctggcccgcc ctcacctctg atagactttg 1080
tgaatctgaa ctgctctact ttgagaagat gaccggtttg gagtaatcag aatgaaccct 1140
cctccttttt aagggttttt tttttttcct ttttctaaaa agctatgtat cgctcctatt 1200
gaaagaccag atccttagag aagtttgtgg tataaaaagg aagtggggac agattcgcag 1260
cacagagtcg ctggcatgtt tcactcctgc ttctctcagc cagctgttta agcctgcggc 1320
gccagcctca cggagggccg tgtgacactc tcgtggtatg tatgggagat ggcagcagtg 1380
gcagcagc caccagggag tggccatttg gggttgggac agggagggtg ttttgggtgg 1440
catagaggtt ttgtattgag ggccagtgat gatgttttga tatttatttc ctgctactta 1500
aatttgaatc tgagtgaatt gtacctattt ctgatgatgt cggtcttgca aagcgacaga 1560
ttcataaagt aatgatgaaa tctttctttc ttcccgtgtg tatttctaag aaatagagcc 1620
aactgatttt gtatgtaaat accaagagca atttacctgg tactaaaccc gcaccccagt 1680
gcggaccctt cccagccctc atcccacttc ctttcctact gtcctggaac ctgtctccat 1740
tgtgtgatcc agccctggtt ctggctgtgg tcagcagatg ccagtgaagg gttttgtgtg 1800
tttaggcctc atttctttgt ctttttccta ctccgttcct ggcatttgct gatttctagt 1860
gtatactctg tagtctcagt tcgtgtttga ttccattcca tggaaataaa aagtatgttg 1920
tacatactgc cgaagaattg tcttgcaagt taaggcttcc ccctttacta taagactata 1980
aataaaaact tattttatcc tt 2002
<210>6
<211>8469
<212>DNA
<213>人
<400>6
atggcggcgg cggcgggcgg cggcagttgc cccgggcctg gctccgcgcg gggccgcttc 60
ccgggccggc cgcggggcgc cggcgggggc gggggccgcg gcggacgggg caacggggcc 120
gaaagagtgc gggtagctct gcggcgcggc ggtggcgcga cggggccggg cggagccgag 180
cggggagg acacggccct gctccgtttg ctggggctcc gccggggcct gcgccggctc 240
cgccgcctgt gggccggccc gcgggtccag cggggccggg gacggggtcg gggccggggc 300
tggggcccga gtcgaggctg cgtgccggag gaggagagca gtgacgggga atccgacgag 360
gaggagtttc agggttttca ttcagatgaa gatgtggccc ccagttccct gcgctctgcg 420
ctccgatccc agcgaggtcg agcgccccga ggtcggggtc gcaagcataa gacgaccccc 480
cttcctcctc ctcgcctagc agatgtggct cctacccccc caaagacccc tgcccggaaa 540
cggggtgagg aaggcacaga acggatggtg caggcactga ctgaacttct ccggcgggcc 600
caggcacccc aagcaccccg gagccgggca tgtgagccct ccaccccccg gcggtctcgg 660
ggacggcccc caggacggcc agcaggcccc tgcaggagga agcagcaagc agtagtggtg 720
agaagcag ctgtgacaat ccccaaacct gagcccccac ctcctgtggt tccagtgaaa 780
catcagactg gcagctggaa atgcaaggag gggcccggtc caggacctgg gacccccagg 840
cgtggaggac agtcaagccg tggaggccgt ggaggcaggg gccgcggccg aggtggtggg 900
ctcccctttg tgatcaagtt tgtttcaagg gccaaaaaag taaagatggg acaattgtcc 960
ttgggactcg aatcaggtca aggtcaaggt caacatgagg aaagttggca ggatgtcccc 1020
caaagaagag ttggatctgg acagggaggg agcccttgct ggaaaaagca ggaacagaag 1080
ctggatgacg aggaagaaga gaagaaagaa gaagaagaaa aagacaagga gggagaagag 1140
aaggaagaaa gagctgtagc tgaggagatg atgccagctg cggaaaagga agaggcaaag 1200
ctgccaccac cgcctctgac tcctccagcc ccttcacctc ctccacccct cccaccccct 1260
tcgacatctc ctccaccccc actctgccct ccaccaccac ccccagtgtc cccaccacct 1320
ctaccatccc ctccaccgcc tcctgcccaa gaggagcagg aggaatcccc tcctcctgtg 1380
gtcccagcta cgtgctccag gaagaggggc cggcctcccc tgactcccag ccagcgggcg 1440
gagcgggaag ctgctcgggc agggccagag ggcacctctc ctcccactcc aacccccagc 1500
accgccacgg gaggccctcc ggaagacagt cccaccgtgg cccccaaaag caccaccttc 1560
ctgaagaata tccggcagtt tattatgcct gtggtgagtg cccgctcctc ccgtgtcatc 1620
aagacacccc ggcgatttat ggatgaagac ccccccaaac ccccaaaggt ggaggtctca 1680
cctgtcctgc gacctcccat taccacctcc ccacctgttc cccaggagcc agcaccagtc 1740
ccctctccac cacgtgcccc aactcctcca tctaccccag ttccactccc tgagaagaga 1800
cggtccatcc taagggaacc cacatttcgc tggacctcac tgacccggga gctgccccct 1860
tcccccag cccctccacc tcccccggcc ccctccccac cccctgctcc tgccacctcc 1920
tcccggaggc ccctactcct tcgggcccct cagtttaccc caagcgaagc ccacctgaag 1980
atctacgaat cggtgcttac tcctcctcct cttggggctc ctgaagcccc tgagccagag 2040
cctcctcctg ccgatgactc tccagctgag cctgagcctc gggcagtggg ccgcaccaac 2100
cacctcagcc tgcctcgatt cgcccctgtg gtcaccactc ctgttaaggc cgaggtgtcc 2160
cctcacgggg ctccagctct gagcaacggg ccacagacac aggctcagct actgcagccc 2220
ctgcaggcct tgcaaaccca gctcctgccc caggcactac cgccaccaca gccacagctg 2280
cagccaccgc cgtcaccaca gcagatgcct cccctggaaa aagcccggat tgcgggcgtg 2340
ggttccttgc cgctgtctgg ggtagaggag aagatgttca gcctcctcaa gagagccaaa 2400
gtgcagctat tcaagatcga tcagcagcag cagcagaagg tggcagcttc catgccgctg 2460
ccctggag ggcagatgga ggaggtggcc ggggctgtca agcagatctc cgacagaggc 2520
cctgtccggt ctgaagatga gtcggtggaa gctaagagag agcggccctc aggtcccgag 2580
tcccctgtgc aaggtccccg catcaaacat gtctgccgtc atgctgctgt ggccctgggt 2640
caggcccggg ccatggtgcc tgaagatgtc cctcgcctca gtgccctccc tctccgggat 2700
cggcaggacc tcgccacaga ggatacatca tcggcgtccg agactgagag tgtcccgtca 2760
cggtcccggc ggggaaaggt ggaggcagca ggccctgggg gagaatcaga gcccacaggt 2820
tctggaggga ccctggccca cacaccccgg cgctcactgc cctcccatca cggcaagaag 2880
atgcgcatgg ctcgatgtgg acactgtcgg ggctgcctac gtgtgcagga ctgtgggtcc 2940
tgtgtcaact gcctagacaa gcccaagttt gggggcccta acaccaagaa gcagtgctgt 3000
gtataccgga agtgtgacaa aatagaggct cggaagatgg aacgactggc taaaaaaggc 3060
cggacgatag tgaagacgct gttgccctgg gattccgatg aatctcctga ggcctcccct 3120
ggtcctccag gcccacgccg gggggcggga gctggggggc cccgggagga ggtggtggcc 3180
cacccagggc ccgaggagca ggactccctc ctgcagcgca agtcagctcg gcgctgcgtc 3240
aaacagcgac cctcctatga tatcttcgag gattcggatg actcggagcc cgggggcccc 3300
cctgctcctc ggcgtcggac cccccgagaa aatgagctgc cactgccaga acctgaggag 3360
cagagccggc cccgcaaacc taccctgcag cctgtgttgc agctcaaggc ccgaaggcgc 3420
ctggacaagg atgctttggc ccctggcccc tttgcttctt ttcccaatgg ctggactgga 3480
aagcagaagt ctcccgatgg tgtgcaccgc gtccgtgtgg attttaagga ggattgtgat 3540
ttagagaacg tgtggctgat ggggggcctg agtgtgctca cctctgtgcc agggggcccc 3600
gatggtgt gcttgctgtg tgccagcaaa ggactccacg agctggtgtt ctgtcaagtc 3660
tgctgtgacc cattccaccc attctgcctg gaggaggccg agcggcccct gccccagcat 3720
cacgacacct ggtgctgccg tcgctgcaaa ttctgccacg tctgtggacg caaaggtcgt 3780
ggatccaagc acctcctgga gtgcgagcgc tgccgccatg cataccaccc ggcctgtctg 3840
gggcccagct atccaacccg ggccacgcgc aaacggcgcc actggatctg ttcagcctgt 3900
gtgcgctgta agagctgtgg ggcaactcca ggcaagaact gggacgtcga gtggtctgga 3960
gattacagcc tctgccccag gtgcacccag ctatatgaga aaggaaacta ctgcccgatc 4020
tgtacacgct gctatgaaga caacgactat gagagcaaga tgatgcagtg cgcacagtgc 4080
gatcactggg tgcatgccaa gtgcgagggg ctctcagatg aagactacga gatcctttca 4140
actgccag actcggtgct gtacacctgc ggaccgtgtg ctggggcagc gcagccccgc 4200
tggcgagagg ccctgagcgg ggccctccag gggggcctgc gccaggtgct ccagggcctg 4260
ctgagctcca aggtggtggg cccactgctg ctctgcaccc agtgtgggcc agatgggaag 4320
caactgcacc caggaccctg cggcctgcaa gctgtgagtc agcgcttcga ggatggccac 4380
tacaagtctg tgcacagctt catggaggac atggtgggca tcctcatgcg gcactcggag 4440
gagggagaga ccccggaccg ccgggctgga ggccagatga aggggctcct gctgaagctg 4500
ctagaatctg cgttcggctg gttcgacgcc cacgacccca agtactggcg acggagtacc 4560
cggctgccaa acggagtcct tcccaatgcg gtgttgcccc catccctgga tcatgtctat 4620
gcgcagtgga gacagcagga accagagacc ccagaatcag ggcagcctcc aggggatccc 4680
tcagcagcat tccagggcaa ggatccggct gccttctcac acctggagga cccccgtcag 4740
tgtgcactct gcctcaaata cggggatgca gactccaagg aggcggggcg gctcttgtac 4800
atcgggcaga acgagtggac acacgtcaac tgtgccatct ggtcggcgga agtcttcgag 4860
gagaacgacg gctccctcaa gaatgtgcat gctgctgtgg cccgagggag gcagatgcgc 4920
tgcgagctct gcctgaagcc tggcgccacg gtgggctgct gcctgtcctc ctgcctcagc 4980
aacttccact tcatgtgtgc ccgggccagc tactgcatct tccaggatga caagaaagtc 5040
ttctgccaga aacacactga tctcctggat ggcaaggaaa ttgtgaaccc cgatggtttt 5100
gatgttctcc gccgagtcta tgtggacttc gagggcatca acttcaagcg gaagttcttg 5160
acggggcttg aacccgatgc catcaacgtg ctcattggtt ccatccgcat tgactccctg 5220
ggtactctgt ctgatctctc ggactgcgag ggacggctct tccccattgg ctaccagtgc 5280
ccgtctgt actggagcac agtggatgct cggaggcgct gctggtatcg gtgccgaatt 5340
ctggagtatc ggccatgggg gccgagggaa gagccagctc acctggaggc tgcagaggag 5400
aaccagacca ttgtgcacag ccccgcccct tcctcagagc ccccaggtgg tgaggacccc 5460
ccactggaca cagatgttct tgtccctgga gctcctgagc gccactcgcc cattcagaac 5520
ctggaccctc cactgcggcc agattcaggc agcgcccctc ctccagcccc ccgttctttt 5580
tcgggggctc gaatcaaagt gcccaactac tcgccatccc ggaggccctt ggggggtgtc 5640
tcctttggcc ccctgccctc ccctggaagt ccatcttcac tgacccacca catccccaca 5700
gtgggagacc cggacttccc agctcccccc agacgttccc gtcgtcccag ccctttggct 5760
cccaggccgc ctccatcacg gtgggcctcc cctcctctaa aaacctcccc tcagctcagg 5820
gtgccccctc ctacctcagt cgtcacagcc ctcacaccta cctcagggga gctggctccc 5880
tggcccgg ccccatctcc accaccccct gaagacctgg gcccagactt cgaggacatg 5940
gaggtggtgt caggactgag tgctgctgac ctggacttcg cggccagcct gctggggact 6000
gagcccttcc aggaagagat tgtagccgct ggggccatgg ggagcagcca cgggggcccg 6060
ggggacagct ccgaggagga gtccagcccc acctcccgct acatccactt ccctgtgact 6120
gtggtgtccg cccctggtct ggcccccagc gctacccctg gagccccccg cattgaacag 6180
ctggacggcg tggacgacgg cactgacagt gaggctgagg cggtgcagca gcctcggggc 6240
cagggcacgc ctccttcggg gccaggagta gtccgggcag gggtccttgg ggctgcaggg 6300
gacagggccc ggcctcctga ggacctgcca tcggaaattg tggattttgt gttgaagaac 6360
ctagggggtc ctggggatgg aggtgctggc cctagagagg agtcactccc cccggcgcct 6420
cccctggcta atggcagcca gccctcccaa ggcctgaccg ccagcccagc tgaccccacc 6480
cgcacatttg cctggctccc aggggcccca ggggtccggg tgttaagcct tggccctgcc 6540
cctgagcccc ccaaacccgc cacatccaaa atcatacttg tcaacaagct ggggcaagta 6600
tttgtgaaga tggctgggga gggtgaacct gtcccacccc cagtgaagca gccacctttg 6660
ccccccacca tttcccccac ggctcccacc tcctggactc tgcccccagg ccccctcctc 6720
ggcgtgctgc ccgtggtcgg agtggtccgc cctgccccgc ccccgccacc ccctcccctg 6780
acgctggtgc tgagcagtgg gccagccagc ccgccccgcc aggccatccg cgtcaagagg 6840
gtgtccactt tctccggccg gtccccgcca gcacctcccc catacaaagc cccccggctg 6900
gatgaagatg gagaggcctc agaggatacc cctcaggttc cagggcttgg cagtggcggg 6960
tttagccgtg tgaggatgaa aacccccaca gtgcgtgggg tccttgacct ggatcggcct 7020
ggagcccg ctggggaaga aagtcctggg cccctccagg aacggtcccc tttgctgcca 7080
cttccggaag atggtcctcc ccaggtcccc gatggtcccc cagacctgct gcttgagtcc 7140
cagtggcacc actattcagg tgaggcttcg agctctgagg aagagcctcc atccccagat 7200
gataaagaga accaggcccc aaaacggact ggcccacatc tgcgcttcga gatcagcagt 7260
gaggatgggt tcagcgttga ggcagagagc ttggaggggg cgtggagaac tctgatcgag 7320
aaagtgcaag aggcccgagg gcatgcccga ctcagacatc tctcctttag tggaatgagt 7380
ggggcgagac tcctgggcat ccaccatgat gctgtcatct tcctggccga gcagctcccc 7440
ggagcccagc gttgccagca ctataagttc cgttaccacc agcagggaga gggccaggag 7500
gagccgcccc tgaatcccca tggggctgct cgggcagagg tctatctccg gaagtgcacc 7560
tgacatgt tcaacttcct ggcctcccag caccgggtgc tccctgaggg ggccacctgt 7620
gatgaggaag aggatgaggt gcagctcagg tcaaccagac gtgccaccag cctggagctg 7680
cccatggcca tgcgttttcg tcaccttaag aagacgtcca aagaagctgt gggtgtctac 7740
agatcagcca tccacgggcg aggcctgttc tgtaagcgca acatcgacgc gggggagatg 7800
gtcatcgagt actctggcat tgtcatccgc tcggtgttga ctgacaagcg ggagaagttc 7860
tacgatggga agggcatcgg gtgctatatg ttccgcatgg atgactttga tgtagtggac 7920
gccacgatgc atggcaatgc cgcccgcttc atcaaccact cctgtgagcc caactgcttc 7980
tctcgggtca tccacgtgga gggccagaaa cacattgtta tcttcgccct gcgccgcatc 8040
ctgcgtggtg aggagctcac ctacgactac aagttcccca tcgaggatgc cagcaacaag 8100
ctgccctgca actgtggcgc caagcgctgc cgtcggttcc ttaactgagg ccgtggctgc 8160
ccaccacgac ccctcacacc tcctgctgcc gtcgctgcca tcttgcccct agcctggggg 8220
ctccctagcc cctcccagag catctcaccc ccaccctcat gttcagggtg gatgtgggca 8280
tgcaggtgac aagggccctg cctccacccc tccagcccat ccagcaatcg ccccctttct 8340
gccctggggg cccaggatgt agatattgta caaaggtttc taaatccctt cttttctatg 8400
cactttttta tttaagaggt ggggtcccag gtgggaaccc ccccacaata aagtctgtca 8460
atgtttgga 8469
<210>7
<211>3704
<212>DNA
<213>人
cagcagcgtg ctaagaagca gtcacataaa cagcagcagg agtaggcctc ctgcttttca 60
aaagcagagt actgcagggt cgcgaaatgc aagacactca gatgtttgaa aatctcccga 120
gttgagaatg gctactgtaa aagcgtcacc aagaaactct gacgatctgg acagtcctaa 180
ctctgtgtta gcaatactta cttccggaaa attaatgcta cttcttgtag atttttgcaa 240
ataggaaacc cccttgaaga agatctcaaa ttacgccccc cacccccaaa aaaagacaaa 300
caggggagaa caaagttttg gcatgcctgc aggaacggtg gcttttttag aaactaccta 360
ggaggcagaa gctaagtgat ttgctcatgc ctcttacctg ggagtagaag gtgggaagaa 420
atggaccgag gctgtgacga gaagacaagg cacagtgcag cttggtgaag ccacacgctg 480
tgcgttct gccccctctt catgcagtgc tgcgggctgg tgcatcgccg gcgagtacgg 540
gtgtcctatg gttcggcaga ctcctacact agccgtccat ccgattccga tgtatctctg 600
gaggaggacc gggaggcagt gcgcagagaa gcggagcggc aggcccaggc acagttggaa 660
aaagcaaaga caaagcccgt tgcatttgcg gttcggacaa atgtcagcta cagtgcggcc 720
catgaagatg atgttccagt gcctggcatg gccatctcat tcgaagcaaa agattttctg 780
catgttaagg aaaaatttaa caatgactgg tggatagggc gattggtaaa agaaggctgt 840
gaaatcggat tcattccaag cccagtcaaa ctagaaaaca tgaggctgca gcatgaacag 900
agagccaagc aagggaaatt ctactccagt aaatcaggag gaaattcatc atccagtttg 960
ggtgacatag tacctagttc cagaaaatca acacctccat catctgctat agacatagat 1020
gctactggct tagatgcaga agaaaatgat attccagcaa accaccgctc ccctaaaccc 1080
agtgcaaaca gtgtaacgtc accccactcc aaagagaaaa gaatgccctt ctttaagaag 1140
acagagcaca ctcctccgta tgatgtggta ccttccatgc gaccagtggt cctagtgggc 1200
ccttctctga agggctacga ggtcacagat atgatgcaaa aagcgctgtt tgatttttta 1260
aaacacagat ttgaagggcg gatatccatc acaagggtca ccgctgacat ctcgcttgcc 1320
aaacgctcgg tattaaacaa tcccagtaag cacgcaataa tagaaagatc caacacaagg 1380
tcaagcttag cggaagttca gagtgaaatc gaaaggattt ttgaacttgc aagaacattg 1440
cagttggtgg tccttgacgc ggatacaatt aatcatccag ctcaactcag taaaacctcc 1500
ttggccccta ttatagtata tgtaaagatt tcttctccta aggttttaca aaggttaata 1560
aaatctcgag ggaaatctca agctaaacac ctcaacgtcc agatggtagc agctgataaa 1620
ggctcagt gtcctccaga gctgttcgat gtgatcttgg atgagaacca gcttgaggat 1680
gcctgtgagc accttgccga ctatctggag gcctactgga aggccaccca tcctcccagc 1740
agtagcctcc ccaaccctct ccttagccgt acattagcca cttcaagtct gcctcttagc 1800
cccaccctag cctctaattc acagggttct caaggtgatc agaggactga tcgctccgct 1860
cctatccgtt ctgcttccca agctgaagaa gaacctagtg tggaaccagt caagaaatcc 1920
cagcaccgct cttcctcctc agccccacac cacaaccatc gcagtgggac aagtcgcggc 1980
ctctccaggc aagagacatt tgactcggaa acccaggaga gtcgagactc tgcctacgta 2040
gagccaaagg aagattattc ccatgaccac gtggaccact atgcctcaca ccgtgaccac 2100
aaccacagag acgagaccca cgggagcagt gaccacagac acagggagtc ccggcaccgt 2160
cccgggacg tggatcgaga gcaggaccac aacgagtgca acaagcagcg cagccgtcat 2220
aaatccaagg atcgctactg tgaaaaggat ggagaagtga tatcaaaaaa acggaatgag 2280
gctggggagt ggaacaggga tgtttacatc ccccaatgag ttttgccctt ttgtgttttt 2340
tttttttttt ttttgaagtc ttgtataact aacagcatcc ccaaaacaaa gtctttgggg 2400
tctacactgc aatcatatgt gatctgtctt gtaatatttt gtattattgc tgttgcttga 2460
atagcaatag catggataga gtattgagat actttttctt ttgtaagtgc tacataaatt 2520
ggcctggtat ggctgcagtc ctccggttgc atactggact cttcaaaaac tgttttgggt 2580
agctgccact tgaacaaaat ctgttgccac ccaggtgatg ttagtgtttt aagaaatgta 2640
gttgatgtat ccaacaagcc agaatcagca cagataaaaa gtggaatttc ttgtttctcc 2700
agatttttaa tacgttaata cgcaggcatc tgatttgcat attcattcat ggaccactgt 2760
ttcttgcttg tacctctggc tgactaaatt tggggacaga ttcagtcttg ccttacacaa 2820
aggggatcat aaagttagaa tctattttct atgtactagt actgtgtact gtatagacag 2880
tttgtaaatg ttatttctgc aaacaaacac ctccttatta tatataatat atatatatat 2940
atcagtttga tcacactatt ttagagtctt aatgccaagt cagcagattt gctttatgaa 3000
ttacagggac tagaaatgcc cacattcagg aaatttgtaa taacattgtc tagacaccta 3060
tcctcattct agtagaaagt gtgtacatac tgtaaatatg tgtgattgct tgacttgaaa 3120
aggtttgaat tctgaatgtt ataccatcct tgtaagtaag tttgtaattt ccaccataaa 3180
ttatggtaaa tataaaactc cagaggttgt tctactccat acagttcaca ctgattgtga 3240
cacattctta gtagctagtg tctgttctag tcactgcact ggagtctacg agccggaact 3300
ctatatgc acgtgtgtgt gtccgtatgt aagaaagtgt gcaccgagtg actgaatggt 3360
tgagatgaat tggaatgctg aagactaacg aagaaactag agactgatat cgagcattct 3420
gcccacctcg ctctgtattt aattaattgt gctatatgtt gctttaacaa cccattgagc 3480
agtcagggaa tgtgagtaag cttgctgcca aaggtaacta ggaaagcatt catctgctgc 3540
ctccttgttt ttgctcctag agagtgaaaa tacaggcaat tttactgtga gtgtttcact 3600
ggaaatgtac aatctttgtg tgttagagta tttgttttag taagaaatgt ttacacagct 3660
tgtggaatta tttcgtggga aaataaattt ttataacttc tccc 3704
<210>8
<211>4184
<212>DNA
<213>人
<400>8
ccggggctga gctgcggcgg cgcctgacaa tgccccctcg cgccccggcc tcggcgcccg 60
ctcccggctc cagcgcgcct gcacgtacgt agccttcacg tgtgtgtgga tacggagtgc 120
atgtgtggag acagaggaat atgctccaac aaatttcgga tagaggcgcc gaagacagga 180
cgtggggaag ctaaagaagt aaacaggtca tggcacgttt aacaaaaaga cgacaggcgg 240
atacaaaagc tatccagcat ctttgggcag ccattgagat tatacggaac cagaagcaga 300
ttgccaacat tgaccgtatt acaaagtata tgtctcgagt ccacggtatg caccctaaag 360
agaccacccg tcagctgagc ttagctgtga aagatggtct tattgtcgaa actctaacag 420
tgggctgcaa aggttcaaaa gctggtattg aacaagaagg atattggttg ccaggagatg 480
agattgactg ggaaacagaa aatcatgact ggtattgttt tgaatgccat ttgcctggag 540
aggtgttgat atgtgacctg tgttttcgtg tgtatcattc caagtgtttg tctgatgagt 600
tcaggcttag agacagcagt agtccctggc agtgcccagt ttgcaggagc attaagaaga 660
agaatacaaa caaacaggag atgggcacat acctcagatt cattgtctcc cgcatgaagg 720
agagggctat agatcttaat aaaaagggga aggacaataa acacccgatg tacaggaggc 780
tggtgcactc agctgtggac gttcccacca ttcaagagaa agtgaatgaa gggaaatacc 840
gaagttatga agagttcaaa gctgatgccc aattgcttct ccacaatacc gtgattttct 900
atggagcaga cagtgagcaa gctgacattg cgaggatgct atataaagac acatgtcatg 960
agctggatga actgcagctt tgcaagaatt gcttttactt gtcaaatgct cgtcctgaca 1020
tggttctg ttatccttgt atacctaatc atgagctggt ttgggctaaa atgaaaggtt 1080
ttgggttttg gccagccaaa gtcatgcaga aagaagacaa tcaagtcgac gttcgcttct 1140
ttggccacca ccaccagagg gcctggattc cttctgaaaa cattcaagat atcacagtca 1200
acattcatcg gctgcacgtg aagcgcagta tgggttggaa aaaggcctgt gatgagctgg 1260
agctgcatca gcgtttccta cgagaaggga gattttggaa atctaagaat gaggaccgag 1320
gtgaggaaga ggcagaatcc agtatctcct ccaccagtaa tgagcagcta aaggtcactc 1380
aagaaccaag agcaaagaaa ggacgacgta atcaaagtgt ggagcccaaa aaggaagaac 1440
cagagcctga aacagaagca gtaagttcta gccaggaaat acccacgatg cctcagccca 1500
tcgaaaaagt ctccgtgtca actcagacaa agaagttaag tgcctcttca ccaagaatgc 1560
catcggag cacccagacc acaaacgacg gcgtgtgtca gagcatgtgc catgacaaat 1620
acaccaagat cttcaatgac ttcaaagacc ggatgaagtc ggaccacaag cgggagacag 1680
agcgtgttgt ccgagaagct ctggagaagc tgcgttctga aatggaagaa gaaaagagac 1740
aagctgtaaa taaagctgta gccaacatgc agggtgagat ggacagaaaa tgtaagcaag 1800
taaaggaaaa gtgtaaggaa gaatttgtag aagaaatcaa gaagctggca acacagcaca 1860
agcaactgat ttctcagacc aagaagaagc agtggtgcta caactgtgag gaggaggcca 1920
tgtaccactg ctgctggaac acatcctact gctccatcaa gtgccagcag gagcactggc 1980
acgcggagca caagcgcacc tgccgccgga aaagatgaag ctggcccttc ccggagtcac 2040
cccgatgatt actcttttca gacacagcgg tttttgtttc caagaagcca aaattgttta 2100
gaatttgctt cccattttgc accagccttt aaacactttt cgtgaagaaa ttttgcacag 2160
tagtttaaat cttttgttaa tgctcctccg aagtttttca gggggtaaaa gtaacatcag 2220
tggagggtat tattttaaat aaattttaat tgagaatttg ttgcattttc agcaaatttt 2280
aaaacatttt taggttttac agagatttta acctttaaac aacagatctt taaaaaacag 2340
gtgaatacaa gtgagtttaa caaagaaaca tttagaatag atctgaatgt aagaactaca 2400
gaactgtttc agaaataaaa catactacct tgatgtgaca tttttttctt aaccttgttg 2460
agctggtttt gttcagctta atttactgtt caaaggcatt atctgttggt cacaccagtg 2520
ggtatatgat tgaatttagg gaacagggtt gacacagcag ggctagtcct gcatattttt 2580
tcttaaatat ttcccaattg tgtttttcat tatttctttt caatatataa cttttataac 2640
aaattattag ctttgatctt gtagtttaaa attgcaggga actggggtaa tcttttactg 2700
ctggatct tagagaaaat gaatatttaa attttaaagt ttgcacattt catctttgtc 2760
ctaacatgag tgcttgtaac aaaataaaca acaaaaacaa agccaaaaac tacctttatc 2820
catatgtgaa attatagatg aggcatacga atttgtttaa tgcttccctt cccttcccac 2880
atatcatctc actgcctatt atctggtgtc acctcatgta tcgtaagtta atactaaaag 2940
aagagaaagc acttaagttt cacagaagcc gttatgtttg tagtaatggg tcattgccta 3000
ctaatgaact ccatcactgt acacagaatg aagaataatg catgttaatt ttcttgtatt 3060
aaagatgccg tgatttgtaa aaagtctgta ttttgcggaa tgtctggatt aagaagcatt 3120
accaatagga atggatcgat agttgaataa tgatttttta tacatagata tataaaatac 3180
agccaggaaa acttaaatta cttttctttt aaaatatctc acaatttatg tggtattttt 3240
aaagactgat cttagaccaa gtcaaattcc catttatcat ttagttattt tttgaggtta 3300
gaataatt tgtacatatt tatttagacc tttgatattt attaaagcaa ttactcacaa 3360
tggaagtgaa agaatcagga gaaaagcctt ttaaaaagta ttctccaggt ttgtcagggt 3420
cactctaaag ataaaaatgt aactaagtct tctgtgaaat atcatccatc taatcttgat 3480
gctgttgcag atggtggtga cacaagttaa ttgacaaact actgccaaat ggtgcacaat 3540
attttgtaaa aagtacccag tagccccatt tcatacaatg tacctaaatt atgcagtaac 3600
ttggcatcat cgttccctcc ttgttgctgt gtaattagtc agtgttgcca cagtgtgtgg 3660
cgctgatgga gatgtcagaa ccgagaacac ttaaccttct ttgattgttt ttcaagtttt 3720
aagacttcga tccaccccta tgagagcaag taattgtgga aatatttttg gtgtaaaatc 3780
attccagagt atgtaatatt taactgatag ctgcatgaaa gtgagattcg tgttactttg 3840
gcttttctgt ctctgttgac acggttgcac atttccaagt tactacagcg tgaaaactgt 3900
gtgtttaaaa aaaaacaaaa ttaaaaaaag agattgtggc ctggttttgt aaaagtttta 3960
ggtaaaatta caattgattg ttttaggaat cattattaaa aattttctgc aaatcataaa 4020
gctatatcga ggtgttgagc ttagccacta tgcacattgt aattattcat tgtggctgtc 4080
cagttctatg atgcattctg gcattttgta agctgctctg actagcaata tatagattca 4140
tttaatgtgt taacattggt taataaatgt atttaaaaaa aact 4184
<210>9
<211>6714
<212>DNA
<213>人
<400>9
ccctaggccc gggtcccgga tccccgcgca cccggccagg ctctggcacg ttttggggga 60
ggtgcctgca ggacccaaca tactcaatga gcttccagcg caatgtccga tcgctcgggg 120
ccgactgcca agggaaagga tggaaagaag tattcctcgc tcaacctgtt tgatacgtat 180
aagggcaagt ccttagagat ccagaaaccc gctgttgccc ctcgccatgg cctgcagagt 240
ctcgggaaag ttgccattgc ccggcgtatg ccacctccag ccaaccttcc aagcctgaaa 300
gccgagaaca aaggcaatga ccccaatgtc tcactagtgc caaaagacgg aacaggatgg 360
gcaagcaaac aggagcagtc cgaccccaag agttccgatg cctcaaccgc tcagccgccg 420
gaatcgcagc cactgccggc ttcacagacg cctgcctcca accagccgaa acgaccccca 480
agcccccg agaacactcc tttggttcca agcggggtaa agtcctgggc acaagccagc 540
gtcacccatg gagcacatgg agatggtgga agggcatcaa gcctactgtc acgattctct 600
cgagaggaat ttccgaccct gcaggcggct ggcgaccagg acaaggctgc caaggaaagg 660
gagtctgccg aacagtcgtc tgggcccgga ccaagcctcc gcccccaaaa ttctacaact 720
tggagggacg gaggtgggcg tggccctgat gagctggagg gcccggactc caaacttcat 780
catggtcatg atccccgggg tgggctacag ccttcaggcc caccccagtt ccctccctac 840
cgcggaatga tgccgccttt catgtatccc ccatatctcc cgttccctcc gccctatgga 900
ccccaggggc cttaccgata ccccactcct gatgggccca gccgttttcc ccgtgtggcg 960
ggcccccgag gctcagggcc accaatgcgc ttagtagagc ctgtgggtcg tccctctatt 1020
ctcaaagagg ataatctcaa agagtttgat cagttggatc aggagaatga tgatggttgg 1080
gcaggggccc atgaagaggt tgactacact gaaaagctca agttcagcga tgaggaagat 1140
gggcgagact ctgatgagga gggagctgag ggccacaggg attcccaatc agcttctggt 1200
gaggaacggc cccctgaagc agatggcaaa aagggcaact cccccaacag cgaaccgccc 1260
actcctaaga cggcctgggc agaaacctct cggcctccag agacagagcc gggacctcct 1320
gccccaaagc ctcccctacc ccctggggac tacccagatc gtgggggtcc tccctgcaag 1380
cccccagcac ctgaagatga ggatgaggca tggcggcagc gacgaaagca gtcgtcatct 1440
gagatttccc tggcagtgga gcgggcccgg cgacggcgag aagaagagga gcggcgcatg 1500
caagaagagc gccgggcagc ctgtgctgag aagctcaagc gactcgatga aaagtttggg 1560
gcacctgaca agcggctcaa agcagagcct gctgccccac ctgctgcccc ttctacccca 1620
tccaccac ctgcagtccc taaagaactc cctgcacctc cagctccacc tccagcatca 1680
gccccaacac cagagaaaga acctgaagag ccagcacagg cccctcctgc ccaatctact 1740
cctactccag gtgtggctgc ggctcccact ctggtgagtg gtggtggcag taccagtagc 1800
accagcagtg gcagcttcga agccagccca gtggaaccac aactgccctc aaaagagggt 1860
cctgaaccac cagaagaggt tcctcctcct accacacccc cagttccaaa ggtggaaccc 1920
aagggtgatg ggattggtcc cacccgccag ccccctagtc agggcttggg ctaccccaaa 1980
tatcagaagt cgttgcctcc tcgtttccag cggcagcagc aggagcagct cctgaagcag 2040
cagcagcagc accagtggca gcagcatcaa cagggctctg cccctcctac cccagtgccc 2100
ccatcaccac cacagcctgt gaccctgggg gctgtgccag ctccacaggc tccacccccg 2160
ccccccaagg ccctgtaccc aggtgctctg ggccggcccc cacccatgcc cccaatgaac 2220
tgatcccc gatggatgat gattcctcct tatgtggacc cccggctcct ccagggtcgt 2280
ccccctctag acttctaccc tcctggtgtg catccctctg gcctagttcc ccgagagcgt 2340
tcagacagtg ggggctcaag ctcagagcca tttgaccgtc atgcacctgc tatgttacgg 2400
gaacggggca ctccaccggt ggatccaaag ttggcctggg taggagatgt cttcaccgcc 2460
acacccgctg aaccccgccc acttacctca cctctgcgcc aggctgcgga tgaggatgac 2520
aaggggatga ggagcgagac tcctccagta cctcccccac caccctatct ggccagttat 2580
ccaggctttc ctgagaatgg agcccctggg cccccaatct ctcgctttcc tctggaggaa 2640
ccagggcccc gtccactccc ctggccccca ggcagtgatg aagtggccaa gatacaaact 2700
ccaccaccca agaaggagcc ccctaaggag gagactgcac agctgacggg gccagaagca 2760
ggccgaaagc ctgcccgcgg agtcgggagt ggaggccagg gccccccacc accacgcaga 2820
gagagtcgca cagagacccg ctggggccct cgtccaggga gcagtcgtcg tggaatccct 2880
ccagaggagc caggggcccc accccgccgg gctgggccta taaagaaacc tccaccacct 2940
acaaaagtag aagagctgcc tcccaagccc ctcgaacagg gggatgaaac ccccaaaccc 3000
ccaaagccag acccactcaa gataaccaag gggaagctag ggggccccaa ggagacccca 3060
cccaatggaa atctttcccc tgccccaagg cttcggaggg actattcgta tgaaagagtg 3120
ggtcctacct cttgccgggg tcggggccga ggcgagtatt ttgccagagg gaggggtttt 3180
cgggggacct atgggggacg agggcgggga gcccgaagcc gggaattccg cagttaccga 3240
gagtttcgag gagatgatgg gcgtggaggt gggacagggg gaccaaacca ccctcctgct 3300
ccccgaggcc gcactgccag cgagacacgg agcgagggtt cagagtatga ggaaatcccc 3360
gcggcgcc ggcagcgggg ctcagaaaca ggcagcgaga cccatgagag tgatctggct 3420
ccttcagaca aggaggctcc cacacccaag gagggaacac tcacccaggt ccctctcgct 3480
cccccaccac caggagcccc accttcacca gccccagccc gcttcactgc ccggggtggg 3540
cgagtcttca ctcccagagg ggtgccatct cgccggggcc gaggaggagg gaggccccct 3600
cctcaagttt gcccaggctg gagccctcca gccaagtctc tggctcccaa gaaacctccc 3660
acaggccctt tgccaccaag taaggagcct ttgaaagaga agttgatccc agggcctctg 3720
tcccctgtgg cgcgcggagg cagcaatgga ggtagcaatg tgggcatgga agatggggag 3780
cgaccccgaa ggaggcgaca tgggagggct cagcagcagg ataaaccgcc tcgtttccgg 3840
aggctgaagc aggaacggga gaatgccgca agggggtctg agggcaagcc ctccctaacc 3900
ttccagcct ccgctcctgc acctgaggag gccctcacaa cagtcacagt ggccccagca 3960
cctcgccggg cagctgccaa gtctcctgat ctgtcaaacc agaactcaga ccaagccaat 4020
gaggaatggg agactgcatc agagagcagt gacttcacca gtgagcgccg aggggacaaa 4080
gaggcacccc caccagtact gctgacaccc aaggctgtgg gaactcctgg gggaggtgga 4140
ggtggagccg taccaggtat ttcagccatg tcccgcggag atctgagcca gagagccaag 4200
gatttgagta aacggagctt ctcaagtcag cggccaggca tggaacggca gaatcggcgc 4260
cctggcccag ggggcaaggc tggcagcagt ggcagcagca gtggaggagg cggtgggggt 4320
cctggaggaa ggaccgggcc aggacgaggc gacaagagga gctggccctc tcccaagaac 4380
cgaagtcgtc ctccagagga gcgtcccccg gggcttcccc tgcctccccc acctcccagc 4440
agttctgctg tcttccgcct ggaccaagtt atccacagca accctgctgg catccaacag 4500
gctctggccc agcttagtag ccgtcaaggg agtgtaactg caccaggggg tcatccaagg 4560
cacaagcctg ggcctcccca agcccctcag ggcccctctc ctaggccccc aacccgatac 4620
gagccccaga gggtcaacag cggcctcagt tctgaccccc actttgagga gccggggcca 4680
atggtgagag gggtgggtgg gactcctcgg gactctgccg gggttagtcc ctttccccct 4740
aaacgtcggg agcggcctcc cagaaaacca gagctgctac aggaggaatc tttgccacct 4800
cctcatagct ctggattctt gggctctaag cctgagggcc caggccctca ggcagagtcc 4860
agagatacag gcacagaggc cctgacccct cacatctgga accgtttaca tactgccact 4920
agccgaaaga gttaccggcc cagctccatg gagccttgga tggagcccct gagtcctttt 4980
gaggatgtgg ctggcacaga aatgagtcag tctgacagtg gggtggacct gagtggggat 5040
tcaggtgt catcaggtcc ctgcagccag cgaagttccc ctgatggagg actcaagggg 5100
gcagcagagg gaccccccaa gaggcctgga ggctcctcac ccctgaatgc tgttccttgt 5160
gagggtccac ctggctctga acctcctagg agaccaccac ctgcccccca cgatggggac 5220
agaaaggagc tgccccggga gcagcctctg ccccctggcc ccattggcac agaacgatca 5280
cagcatacag accgaggcac agagcctggc cccattcggc catcccatcg acctggtccc 5340
ccagtccagt ttggcactag tgacaaggac tcagacttac gcctagtggt aggagacagc 5400
ttgaaagcag agaaggagct aacagcatca gtcactgagg ccattcctgt atcacgagac 5460
tgggagctgc ttcccagtgc tgctgcctct gctgagccac aatccaagaa cctggattct 5520
gggcactgtg tcccggagcc cagctcctca ggccagcgcc tgtatcctga ggttttctat 5580
ggcagtgctg ggccttccag ttctcagatc tctgggggag ccatggactc tcaattacat 5640
aaacagtg gaggcttccg ccctgggaca ccctcactgc acccttacag atcacagccc 5700
ctatacctac cccccggccc agcccctccc tcagcactgc tctctggggt agctctcaag 5760
ggccagtttc tggatttctc cacaatgcaa gctacagagc tggggaagtt gccggctgga 5820
ggagttctct accctccacc ttccttcctc tactctccgg ctttctgccc cagtcctttg 5880
cctgacacat cgttgcttca ggtacgccag gatctgccat ccccttcgga tttttattct 5940
actcctctgc agcctggtgg ccaaagtggc tttctccctt caggggctcc tgcccagcag 6000
atgcttctac ccatggtaga ctcacagctg cctgtggtga actttggctc cctgccgcca 6060
gcaccacctc ctgccccacc tcccctttct ctgttacctg tgggccctgc tctgcagccc 6120
cccagcctgg ctgtgcggcc cccacctgct cctgctactc gggtgctgcc ttcacctgcc 6180
aggcccttcc ccgctagctt ggggcgagca gagctgcatc cagtggaact aaagccgttc 6240
caggattatc aaaaactgag cagcaacctt gggggacctg gatcatcacg gactccccca 6300
actggaaggt ccttctctgg cctcaattcc cgtctcaagg ccacgccttc cacctacagt 6360
ggagtcttcc gcacccagcg cgtcgacctt taccagcagg cctccccacc agatgccctg 6420
cgctggatac ctaagccttg ggagcggaca gggctgccac ctcgagaagg gccctcccga 6480
cgggcagagg agcctgggtc ccgaggggac aaggagcctg ggttgccccc accccgctga 6540
gggagttcct cttgccccct acccccgggg cttgtatata gattataaat atataagggg 6600
gaaaggggtg ggcggggagg ggttgtgggg ctggggcctc acttcccctc ctcccccttc 6660
ccctggtccc ctgtccctgg ggctgtttgt taaaaaagag taataaaagg attt 6714
<210>10
<211>2197
<212>DNA
<213>人
<400>10
gccgcgaggg cggggcccgc agttcggttg cgctgcggag cgcagctgtg agggagtcgc 60
tgtgatccgg ggccccggaa cccgagctgg agctgaagcg caggctgcgg ggcgcggagt 120
cgggaggcct gagtgttcct tccagcatgt cggaggggga gtcccagaca gtacttagca 180
gtggctcaga cccaaaggta gaatcctcat cttcagctcc tggcctgaca tcagtgtcac 240
ctcctgtgac ctccacaacc tcagctgctt ccccagagga agaagaagaa agtgaagatg 300
tctgagat tttggaagag tcgccctgtg ggcgctggca gaagaggcga gaagaggtga 360
atcaacggaa tgtaccaggt attgacagtg catacctggc catggataca gaggaaggtg 420
tagaggttgt gtggaatgag gtacagttct ctgaacgcaa gaactacaag ctgcaggagg 480
aaaaggttcg tgctgtgttt gataatctga ttcaattgga gcatcttaac attgttaagt 540
ttcacaaata ttgggctgac attaaagaga acaaggccag ggtcattttt atcacagaat 600
acatgtcatc tgggagtctg aagcaatttc tgaagaagac caaaaagaac cacaagacga 660
tgaatgaaaa ggcatggaag cgttggtgca cacaaatcct ctctgcccta agctacctgc 720
actcctgtga cccccccatc atccatggga acctgacctg tgacaccatc ttcatccagc 780
acaacggact catcaagatt ggctctgtgg ctcctgacac tatcaacaat catgtgaaga 840
ct tgtcgaga agagcagaag aatctacact tctttgcacc agagtatgga gaagtcacta 900
atgtgacaac agcagtggac atctactcct ttggcatgtg tgcactggag atggcagtgc 960
tggagattca gggcaatgga gagtcctcat atgtgccaca ggaagccatc agcagtgcca 1020
tccagcttct agaagaccca ttacagaggg agttcattca aaagtgcctg cagtctgagc 1080
ctgctcgcag accaacagcc agagaacttc tgttccaccc agcattgttt gaagtgccct 1140
cgctcaaact ccttgcggcc cactgcattg tgggacacca acacatgatc ccagagaacg 1200
ctctagagga gatcaccaaa aacatggata ctagtgccgt actggctgaa atccctgcag 1260
gaccaggaag agaaccagtt cagactttgt actctcagtc accagctctg gaattagata 1320
aattccttga agatgtcagg aatgggatct atcctctgac agcctttggg ctgcctcggc 1380
cccagcagcc acagcaggag gaggtgacat cacctgtcgt gcccccctct gtcaagactc 1440
acacctga accagctgag gtggagactc gcaaggtggt gctgatgcag tgcaacattg 1500
agtcggtgga ggagggagtc aaacaccacc tgacacttct gctgaagttg gaggacaaac 1560
tgaaccggca cctgagctgt gacctgatgc caaatgagaa tatccccgag ttggcggctg 1620
agctggtgca gctgggcttc attagtgagg ctgaccagag ccggttgact tctctgctag 1680
aagagacctt gaacaagttc aattttgcca ggaacagtac cctcaactca gccgctgtca 1740
ccgtctcctc ttagagctca ctcgggccag gccctgatct gcgctgtggc tgtccctgga 1800
cgtgctgcag ccctcctgtc ccttcccccc agtcagtatt accctgtgaa gccccttccc 1860
tcctttatta ttcaggaggg ctgggggggc tccctggttc tgagcatcat cctttcccct 1920
cccctctctt cctcccctct gcactttgtt tacttgtttt gcacagacgt gggcctgggc 1980
cttctcagca gccgccttct agttgggggc tagtcgctga tctgccggct cccgcccagc 2040
gtgtggaa aggaggccca cgggcactag gggagccgaa ttctacaatc ccgctggggc 2100
ggccggggcg ggagagaaag gtggtgctgc agtggtggcc ctggggggcc attcgattcg 2160
cctcagttgc tgctgtaata aaagtctact ttttgct 2197
<210>11
<211>6113
<212>DNA
<213>人
<400>11
taatacttaa ttaccttcta ataattggag cagaagatga acccaactaa tcctttcagt 60
gggcagcagc ctagtgcttt ttcggcgtct tctagtaatg taggaacact tccatctaag 120
ccgccatttc gatttggtca accttctctt tttggacaaa acagtacctt atctgggaag 180
agctcgggat tttcacaggt atccagcttt ccagcgtctt ctggagtaag tcattcctct 240
tcagtgcaaa cattagggtt cacccaaacc tcaagtgttg gacccttttc tggacttgag 300
cacacttcca cctttgtggc tacctctggg ccttcaagtt catctgtgct gggaaacaca 360
ggatttagtt ttaaatcacc caccagtgtt ggggctttcc caagcacttc tgcttttgga 420
caagaagctg gagaaatagt gaactctggt tttgggaaaa cagaattcag ctttaaacct 480
ctggaaaatg cagtgttcaa accaatactg ggggctgaat ctgagccaga gaaaacccag 540
agccaaattg cttctgggtt ttttacattt tcccacccaa ttagtagtgc acctggaggc 600
ctggcccctt tctcttttcc tcaagtaaca agtagttcag ctaccacttc aaattttacc 660
ttcaaaac ctgttagtag taataattca ttatctgcct ttacccctgc tttgtcaaac 720
caaaatgtag aggaagagaa gagaggacct aagtcaatat ttggaagttc taataatagc 780
ttcagtagct tccctgtatc atctgcggtt ttgggcgaac ctttccaggc tagcaaagca 840
ggtgtcaggc aggggtgtga agaagctgtt tcccaggtgg aaccacttcc cagcctaatg 900
aaaggactga aaaggaagga ggaccaggat cgctccccaa ggagacatgg ccacgagcca 960
gcagaagatt cggatcctct gtcccggggc gatcatcctc cagacaaacg acctgtccgc 1020
ctgaatcgac cccggggagg tactttattt ggtcggacga tacaggatgt tttcaaaagc 1080
aataaggaag taggtcgtct gggcaacaag gaggccaaaa aggaaactgg ctttgttgag 1140
tctgcagaaa gtgaccacat ggctatccca ggagggaatc agtctgtcct ggcaccttcc 1200
gattccag gtgtgaataa agaggaagaa actgaaagta gagagaagaa agaagattct 1260
ctaagaggaa ctccggcgcg tcagagtaac agaagcgaga gcacagacag tcttgggggc 1320
ttgtctccct ctgaagtcac agccatccag tgcaagaaca tccctgacta cctcaacgac 1380
aggaccattc tggagaacca ttttggcaaa attgctaaag tgcagcgcat ctttaccagg 1440
cgcagcaaaa agcttgcagt ggtacatttc tttgatcatg catctgcagc cctggctaga 1500
aagaagggga aaagtttgca taaagacatg gctatctttt ggcacaggaa gaaaataagc 1560
cccaataaga aacccttttc cctgaaggag aagaaaccag gtgacggtga agtcagcccg 1620
agcacagagg atgcaccctt tcagcactct cctcttggca aggccgcagg gaggactggt 1680
gctagcagcc tcctgaataa aagctctcca gtgaagaagc caagtcttct aaaggcccac 1740
caattcgagg gagactcttt tgactcagcc tccgagggct ccgagggcct cgggccatgt 1800
gtgctctccc tcagtaccct gataggcact gtggctgaga catccaagga gaagtaccgc 1860
ctgcttgacc agagagacag gatcatgcgg caagctcggg tgaagagaac cgatctggac 1920
aaagcgagga cttttgttgg cacctgcctg gatatgtgtc ctgagaagga gaggtacatg 1980
cgggagaccc gtagccagct gagcgtgttc gaagtggtcc cagggactga ccaggtggac 2040
cacgcagcag ctgtgaaaga gtacagtcgg tcctcggcgg atcaggagga gcccctgccc 2100
cacgagctgc ggcccttgcc agtgctcagc aggaccatgg actacctggt gacccagatc 2160
atggaccaga aggagggcag cctgcgggat tggtatgact tcgtgtggaa ccgcacgcgt 2220
ggcatacgga aggatatcac gcagcagcac ctctgtgacc ccctgacggt gtccctgatt 2280
gagaagtgca cccggtttca catccactgt gcccacttca tgtgtgagga gcccatgtcc 2340
ctttgatg ccaagatcaa taatgagaac atgaccaagt gcctgcagag cctgaaggag 2400
atgtaccagg acctgagaaa caagggtgtc ttctgtgcca gcgaagcgga gttccagggc 2460
tacaatgttc tgctcagtct caacaaggga gacatcctaa gagaagtaca acagttccat 2520
cctgctgtta gaaactcatc tgaggtgaaa tttgctgttc aggcttttgc tgcattgaac 2580
agtaataatt ttgtgagatt tttcaaactg gtccagtcag cttcttacct gaacgcttgt 2640
cttttacact gttacttcag tcagatccgc aaggatgctc tccgggcgct caactttgcg 2700
tacacggtga gcacacagcg atctaccatc tttcccctgg atggtgtggt gcgcatgctg 2760
ctgttcagag actgtgaaga ggccaccgac ttcctcacct gccacggcct caccgtttcc 2820
gacggctgtg tggagctgaa ccggtctgca ttcctggaac cagagggatt atccaagacc 2880
aggaagtcgg tgtttattac taggaagctg acggtgtcag tcggggaaat tgtgaacgga 2940
gggccattgc cccccgtccc tcgtcatacc cctgtgtgca gcttcaactc ccagaacaag 3000
tacatcgggg agagcctggc cgcggagctg cccgtcagca cccagagacc cggctccgac 3060
acagtgggcg gagggagagg agaggagtgt ggtgtagagc cggatgcacc cctgtccagt 3120
ctcccacagt ctctaccagc ccctgcgccc tcaccagtgc ctctgcctcc tgtcctggca 3180
ctgaccccgt ctgtggcgcc cagcctcttc cagctgtctg tgcagcctga accaccgcct 3240
ccagagcccg tgcccatgta ctctgacgag gacctggcgc aggtggtgga cgagctcatc 3300
caggaggccc tgcagaggga ctgtgaggaa gttggctctg cgggtgctgc ctacgcagct 3360
gccgccctgg gtgtttctaa tgctgctatg gaggatttgt taacagctgc aaccacgggc 3420
attttgaggc acattgcagc tgaagaagtg tctaaggaaa gagagcgaag ggagcaggag 3480
aggcagcggg ctgaagagga aaggttgaaa caagagagag agctggtgtt aagtgagctg 3540
agccagggcc tggccgtgga gctgatggaa cgcgtgatga tggagtttgt gagggaaacc 3600
tgctcccagg agttgaagaa tgcagtagag acagaccaga gggtccgtgt ggcccgttgc 3660
tgtgaggatg tctgtgccca cttagtggac ttgtttctcg tggaggaaat cttccagact 3720
gcaaaggaga ccctccagga gcttcagtgc ttctgcaagt atctacagcg gtggagggaa 3780
gctgtcacag cccgcaagaa actgaggcgc caaatgcggg ctttccctgc tgcgccctgc 3840
tgcgtggacg tgagcgaccg gctgagggcg ctggcgccca gcgcagagtg ccccattgct 3900
gaagagaacc tggccagggg cctcctggac ctgggccatg cagggagatt gggcatctcc 3960
tgcaccaggt taaggcggct cagaaacaag acagctcacc agatgaaggt tcagcacttc 4020
taccagcagc tgctgagtga tgtggcatgg gcgtctctgg acctgccatc cctcgtggct 4080
gcacctcc ctgggaggca ggagcatgtg ttttggaagc tggtgctggt gttgccggat 4140
gtagaggagc agtccccaga gagttgtggc agaattctag caaattggtt aaaagtcaag 4200
ttcatgggag atgaaggctc agtggatgac acatccagcg atgctggtgg gattcagacg 4260
ctttcgcttt tcaactcact tagcagcaaa ggggatcaga tgatttctgt taacgtgtgt 4320
ataaaggtgg cccatggcgc cctcagtgat ggtgccattg atgctgtgga gacacagaag 4380
gacctcctgg gagccagtgg gctcatgctg ctgcttcccc ccaaaatgaa gagtgaggac 4440
atggcagagg aggacgtgta ctggctgtcg gccttgctgc agctcaagca gctcctgcag 4500
gctaagccct tccagcctgc gcttcctctg gtggttcttg tgcctagccc aggaggggac 4560
gccgttgaga aggaagtaga agatggtctg atgctacagg acttggtttc agctaagctg 4620
ttcagatt acactgttac cgagatccct gataccatta atgatctaca aggttcaact 4680
aaggttttgc aagcagtgca gtggctggtt tcccactgcc cccattccct tgacctctgc 4740
tgccagactc tcattcagta cgtcgaagac gggattggcc atgagtttag tggccgcttt 4800
ttccatgaca gaagagagag gcgtctgggc ggtcttgctt ctcaggagcc tggcgccatc 4860
attgagctgt ttaacagtgt gctgcagttc ctggcttctg tggtgtcctc tgaacagctg 4920
tgtgacctgt cctggcctgt cactgagttt gctgaggcag ggggcagccg gctgcttcct 4980
cacctgcact ggaatgcccc agagcacctg gcctggctga agcaggctgt gctcgggttc 5040
cagcttccgc agatggacct tccacccctg ggggccccct ggctccccgt gtgctccatg 5100
gttgtccagt acgcctccca gatccccagc tcacgccaga cacagcctgt cctccagtcc 5160
caggtggaga acctgctcca cagaacctac tgtaggtgga agagcaagag tccctcccca 5220
gtccatgggg caggcccctc ggtcatggag atcccatggg atgatcttat cgccttgtgt 5280
atcaaccaca agctgagaga ctggacgccc ccccggcttc ctgttacatc agaggcgctg 5340
agtgaagatg gtcagatatg tgtgtatttt tttaaaaacg atttgaaaaa atatgatgtt 5400
cctttgtcgt gggaacaagc caggttgcag acgcagaagg agctacagct gagagaggga 5460
cgtttggcaa taaagccttt tcatccttct gcaaacaatt ttcccatacc attgcttcac 5520
atgcaccgta actggaagag gagcacagag tgtgctcaag aggggaggat tcccagcaca 5580
gaggatctga tgcgaggagc ttctgctgag gagctcttgg cgcagtgttt gtcgagcagt 5640
ctgctgctgg agaaagaaga gaacaagagg tttgaagatc agcttcagca atggttgtct 5700
gaagactcag gagcatttac ggatttaact tcccttcccc tctatcttcc tcagactcta 5760
gtctcttt ctcacactat tgaacctgtg atgaaaacat ctgtaactac tagcccacag 5820
agtgacatga tgagggagca actgcagctg tcagaggcga caggaacgtg tctaggcgaa 5880
cgactaaagc acctggaaag gctgatccgg agttcaaggg aagaggaagt tgcctctgag 5940
ctccatctct ctgcgctgct agacatggtg gacatttgag cagcctgacc tgtggggagg 6000
gggtctctcc cgaagagttt ctgtttttac tcaaaataat gttattctca gatgcttgat 6060
gcactgttgg aaatgtgatt aatttaatca tgcagataaa ccatttaaat gtc 6113
<210>12
<211>6493
<212>DNA
<213>人
<400>12
gaagtccggc cttccgagag ctagctgtcc gccgcggccc ccgcacgccg ggcagccgtc 60
cctcgccgcc tcgggcgcgc caccatgggg ccccggctca gcgtctggct gctgctgctg 120
cccgccgccc ttctgctcca cgaggagcac agccgggccg ctgcgaaggg tggctgtgct 180
ggctctggct gtggcaaatg tgactgccat ggagtgaagg gacaaaaggg tgaaagaggc 240
ctcccggggt tacaaggtgt cattgggttt cctggaatgc aaggacctga ggggccacag 300
ggaccaccag gacaaaaggg tgatactgga gaaccaggac tacctggaac aaaagggaca 360
agaggacctc cgggagcatc tggctaccct ggaaacccag gacttcccgg aattcctggc 420
caagacggcc cgccaggccc cccaggtatt ccaggatgca atggcacaaa gggggagaga 480
gggccgctcg ggcctcctgg cttgcctggt ttcgctggaa atcccggacc accaggctta 540
ccagggatga agggtgatcc aggtgagata cttggccatg tgcccgggat gctgttgaaa 600
ggtgaaagag gatttcccgg aatcccaggg actccaggcc caccaggact gccagggctt 660
caaggtcctg ttgggcctcc aggatttacc ggaccaccag gtcccccagg ccctcccggc 720
cctccaggtg aaaagggaca aatgggctta agttttcaag gaccaaaagg tgacaagggt 780
gaccaagggg tcagtgggcc tccaggagta ccaggacaag ctcaagttca agaaaaagga 840
gacttcgcca ccaagggaga aaagggccaa aaaggtgaac ctggatttca ggggatgcca 900
ggggtcggag agaaaggtga acccggaaaa ccaggaccca gaggcaaacc cggaaaagat 960
ggtgacaaag gggaaaaagg gagtcccggt tttcctggtg aacccgggta cccaggactc 1020
ataggccgcc agggcccgca gggagaaaag ggtgaagcag gtcctcctgg cccacctgga 1080
tgttatag gcacaggacc tttgggagaa aaaggagaga ggggctaccc tggaactccg 1140
gggccaagag gagagccagg cccaaaaggt ttcccaggac taccaggcca acccggacct 1200
ccaggcctcc ctgtacctgg gcaggctggt gcccctggct tccctggtga aagaggagaa 1260
aaaggtgacc gaggatttcc tggtacatct ctgccaggac caagtggaag agatgggctc 1320
ccgggtcctc ctggttcccc tgggccccct gggcagcctg gctacacaaa tggaattgtg 1380
gaatgtcagc ccggacctcc aggtgaccag ggtcctcctg gaattccagg gcagccagga 1440
tttataggcg aaattggaga gaaaggtcaa aaaggagaga gttgcctcat ctgtgatata 1500
gacggatatc gggggcctcc cgggccacag ggacccccgg gagaaatagg tttcccaggg 1560
cagccagggg ccaagggcga cagaggtttg cctggcagag atggtgttgc aggagtgcca 1620
gccctcaag gtacaccagg gctgataggc cagccaggag ccaaggggga gcctggtgag 1680
ttttatttcg acttgcggct caaaggtgac aaaggagacc caggctttcc aggacagccc 1740
ggcatgccag ggagagcggg ttctcctgga agagatggcc atccgggtct tcctggcccc 1800
aagggctcgc cgggttctgt aggattgaaa ggagagcgtg gcccccctgg aggagttgga 1860
ttcccaggca gtcgtggtga caccggcccc cctgggcctc caggatatgg tcctgctggt 1920
cccattggtg acaaaggaca agcaggcttt cctggaggcc ctggatcccc aggcctgcca 1980
ggtccaaagg gtgaaccagg aaaaattgtt cctttaccag gcccccctgg agcagaagga 2040
ctgccggggt ccccaggctt cccaggtccc caaggagacc gaggctttcc cggaacccca 2100
ggaaggccag gcctgccagg agagaagggc gctgtgggcc agccaggcat tggatttcca 2160
gggccccccg gccccaaagg tgttgacggc ttacctggag acatggggcc accggggact 2220
ccaggtcgcc cgggatttaa tggcttacct gggaacccag gtgtgcaggg ccagaaggga 2280
gagcctggag ttggtctacc gggactcaaa ggtttgccag gtcttcccgg cattcctggc 2340
acacccgggg agaaggggag cattggggta ccaggcgttc ctggagaaca tggagcgatc 2400
ggaccccctg ggcttcaggg gatcagaggt gaaccgggac ctcctggatt gccaggctcc 2460
gtggggtctc caggagttcc aggaataggc ccccctggag ctaggggtcc ccctggagga 2520
cagggaccac cggggttgtc aggccctcct ggaataaaag gagagaaggg tttccccgga 2580
ttccctggac tggacatgcc gggccctaaa ggagataaag gggctcaagg actccctggc 2640
ataacgggac agtcggggct ccctggcctt cctggacagc agggggctcc tgggattcct 2700
gggtttccag gttccaaggg agaaatgggc gtcatgggga cccccgggca gccgggctca 2760
aggaccag tgggtgctcc tggattaccg ggtgaaaaag gggaccatgg ctttccgggc 2820
tcctcaggac ccaggggaga ccctggcttg aaaggtgata agggggatgt cggtctccct 2880
ggcaagcctg gctccatgga taaggtggac atgggcagca tgaagggcca gaaaggagac 2940
caaggagaga aaggacaaat tggaccaatt ggtgagaagg gatcccgagg agaccctggg 3000
accccaggag tgcctggaaa ggacgggcag gcaggacagc ctgggcagcc aggacctaaa 3060
ggtgatccag gtataagtgg aaccccaggt gctccaggac ttccgggacc aaaaggatct 3120
gttggtggaa tgggcttgcc aggaacacct ggagagaaag gtgtgcctgg catccctggc 3180
ccacaaggtt cacctggctt acctggagac aaaggtgcaa aaggagagaa agggcaggca 3240
ggcccacctg gcataggcat cccagggctg cgaggtgaaa agggagatca agggatagcg 3300
ggtttcccag gaagccctgg agagaaggga gaaaaaggaa gcattgggat cccaggaatg 3360
cagggtccc caggccttaa agggtctccc gggagtgttg gctatccagg aagtcctggg 3420
ctacctggag aaaaaggtga caaaggcctc ccaggattgg atggcatccc tggtgtcaaa 3480
ggagaagcag gtcttcctgg gactcctggc cccacaggcc cagctggcca gaaaggggag 3540
ccaggcagtg atggaatccc ggggtcagca ggagagaagg gtgaaccagg tctaccagga 3600
agaggattcc cagggtttcc aggggccaaa ggagacaaag gttcaaaggg tgaggtgggt 3660
ttcccaggat tagccgggag cccaggaatt cctggatcca aaggagagca aggattcatg 3720
ggtcctccgg ggccccaggg acagccgggg ttaccgggat ccccaggcca tgccacggag 3780
gggcccaaag gagaccgcgg acctcagggc cagcctggcc tgccaggact tccgggaccc 3840
atggggcctc cagggcttcc tgggattgat ggagttaaag gtgacaaagg aaatccaggc 3900
tggccaggag cacccggtgt cccagggccc aagggagacc ctggattcca gggcatgcct 3960
ggtattggtg gctctccagg aatcacaggc tctaagggtg atatggggcc tccaggagtt 4020
ccaggatttc aaggtccaaa aggtcttcct ggcctccagg gaattaaagg tgatcaaggc 4080
gatcaaggcg tcccgggagc taaaggtctc ccgggtcctc ctggcccccc aggtccttac 4140
gacatcatca aaggggagcc cgggctccct ggtcctgagg gccccccagg gctgaaaggg 4200
cttcagggac tgccaggccc gaaaggccag caaggtgtta caggattggt gggtatacct 4260
ggacctccag gtattcctgg gtttgacggt gcccctggcc agaaaggaga gatgggacct 4320
gccgggccta ctggtccaag aggatttcca ggtccaccag gccccgatgg gttgccagga 4380
tccatggggc ccccaggcac cccatctgtt gatcacggct tccttgtgac caggcatagt 4440
caaacaatag atgacccaca gtgtccttct gggaccaaaa ttctttacca cgggtactct 4500
gctctacg tgcaaggcaa tgaacgggcc catggccagg acttgggcac ggccggcagc 4560
tgcctgcgca agttcagcac aatgcccttc ctgttctgca atattaacaa cgtgtgcaac 4620
tttgcatcac gaaatgacta ctcgtactgg ctgtccaccc ctgagcccat gcccatgtca 4680
atggcaccca tcacggggga aaacataaga ccatttatta gtaggtgtgc tgtgtgtgag 4740
gcgcctgcca tggtgatggc cgtgcacagc cagaccattc agatcccacc gtgccccagc 4800
gggtggtcct cgctgtggat cggctactct tttgtgatgc acaccagcgc tggtgcagaa 4860
ggctctggcc aagccctggc gtcccccggc tcctgcctgg aggagtttag aagtgcgcca 4920
ttcatcgagt gtcacggccg tgggacctgc aattactacg caaacgctta cagcttttgg 4980
ctcgccacca tagagaggag cgagatgttc aagaagccta cgccgtccac cttgaaggca 5040
gggagctgc gcacgcacgt cagccgctgc caagtctgta tgagaagaac ataatgaagc 5100
ctgactcagc taatgtcaca acatggtgct acttcttctt ctttttgtta acagcaacga 5160
accctagaaa tatatcctgt gtacctcact gtccaatatg aaaaccgtaa agtgccttat 5220
aggaatttgc gtaactaaca caccctgctt cattgacctc tacttgctga aggagaaaaa 5280
gacagcgata agctttcaat agtggcatac caaatggcac ttttgatgaa ataaaatatc 5340
aatattttct gcaatccaat gcactgatgt gtgaagtgag aactccatca gaaaaccaaa 5400
gggtgctagg aggtgtgggt gccttccata ctgtttgccc attttcattc ttgtattata 5460
attaattttc tacccccaga gataaatgtt tgtttatatc actgtctagc tgtttcaaaa 5520
tttaggtccc ttggtctgta caaataatag caatgtaaaa atggtttttt gaacctccaa 5580
atggaattac agactcagta gccatatctt ccaacccccc agtataaatt tctgtctttc 5640
tgctatgtgt ggtactttgc agctgctttt gcagaaatca caattttcct gtggaataaa 5700
gatggtccaa aaatagtcaa aaattaaata tatatatata ttagtaattt atatagatgt 5760
cagcaattag gcagatcaag gtttagttta acttccactg ttaaaataaa gcttacatag 5820
ttttcttcct ttgaaagact gtgctgtcct ttaacatagg tttttaaaga ctaggatatt 5880
gaatgtgaaa catccgtttt cattgttcac ttctaaacca aaaattatgt gttgccaaaa 5940
ccaaacccag gttcatgaat atggtgtcta ttatagtgaa acatgtactt tgagcttatt 6000
gtttttattc tgtattaaat attttcaggg ttttaaacac taatcacaaa ctgaatgact 6060
tgacttcaaa agcaacaacc ttaaaggccg tcatttcatt agtattcctc attctgcatc 6120
ctggcttgaa aaacagctct gttgaatcac agtatcagta ttttcacacg taagcacatt 6180
ggccattt ccgtggtttc tcatgagctg tgttcacaga cctcagcagg gcatcgcatg 6240
gaccgcagga gggcagattc ggaccactag gcctgaaatg acatttcact aaaagtctcc 6300
aaaacatttc taagactact aaggcctttt atgtaatttc tttaaatgtg tatttcttaa 6360
gaattcaaat ttgtaataaa actatttgta taaaaattaa gcttttatta atttgttgct 6420
agtattgcca cagacgcatt aaaagaaact tactgcacaa gctgctaata aatttgtaag 6480
ctttgcatac ctt 6493
<210>13
<211>2718
<212>DNA
<213>人
<400>13
gcgaccgctc cccggcggga gccagcgaag gtttccatgt cagaggccga tggagaactg 60
aagattgcca cctacgcaca aaggccattg agacacttcg tgtagctgga agacaccaac 120
ttcctgacag gagctttatt tcatttggga tttcaagttt acagatggta tcttctcaaa 180
agttggaaaa acctatagag atgggcagta gcgaacccct tcccatcgca gatggtgaca 240
ggaggaggaa gaagaagcgg aggggccggg ccactgactc cttgccagga aagtttgaag 300
atatgtacaa gctgacctct gaattgcttg gagagggagc ctatgccaaa gttcaaggtg 360
ccgtgagcct acagaatggc aaagagtatg ccgtcaaaat catcgagaaa caagcagggc 420
acagtcggag tagggtgttt cgagaggtgg agacgctgta tcagtgtcag ggaaacaaga 480
acattttgga gctgattgag ttctttgaag atgacacaag gttttacttg gtctttgaga 540
aattgcaagg aggttccatc ttagcccaca tccagaagca aaagcacttc aatgagcgag 600
aagccagccg agtggtgcgg gacgttgctg ctgcccttga cttcctgcat accaaagaca 660
aagtctctct ctgtcaccta ggctggagtg ctatggcgcc atcagggctc actgcagccc 720
caacctccct gggctccagt gatcctccca cctcagcctc ccaagtagct gggactacag 780
gcattgctca tcgtgatctg aaaccagaaa atatattgtg tgaatctcca gaaaaggtgt 840
ctccagtgaa aatctgtgac tttgacttgg gcagtgggat gaaactgaac aactcctgta 900
cccccataac cacaccagag ctgaccaccc catgtggctc tgcagaatac atggcccctg 960
aggtagtgga ggtcttcacg gaccaggcca cattctacga caagcgctgt gacctgtgga 1020
ctgggcgt ggtcctctac atcatgctga gtggctaccc acccttcgtg ggtcactgcg 1080
gggccgactg tggctgggac cggggcgagg tctgcagggt gtgccagaac aagctgtttg 1140
aaagcatcca ggaaggcaag tatgagtttc ctgacaagga ctgggcacac atctccagtg 1200
aagccaaaga cctcatctcc aagctcctgg tgcgagatgc aaagcagaga cttagcgccg 1260
cccaagttct gcagcaccca tgggtgcagg ggcaagctcc agaaaaggga ctccccacgc 1320
cgcaagtcct ccagaggaac agcagcacaa tggacctgac gctcttcgca gctgaggcca 1380
tcgcccttaa ccgccagcta tctcagcacg aagagaacga actagcagag gagccagagg 1440
cactagctga tggcctctgc tccatgaagc tttcccctcc ctgcaagtca cgcctggccc 1500
ggagacgggc cctggcccag gcaggccgtg gtgaagacag gagcccgccc acagcactct 1560
aatgctcc agtcacacct tataggccct aggcctggcc aggcattgtc ccctggaaac 1620
ctgtgtggct aaagtctgct gagcaggcag cagcctctgc tctgtggctc cattcaggct 1680
ttttcatcta cgaaggccct gaggttccca tcaaccccca tttccctagg gtcctggagg 1740
aaaaagcttt ttccaaaggg gttgtctttg aaaaggaaag caatcacttc tcactttgca 1800
taattgcctg cagcaggaac atctcttcac tgggctccac ctgctcaccc gcctgcagat 1860
ctgggatcca gcctgctctc accgctgtag ctgtggcggc tggggctgca gcctgcaggg 1920
agaagcaaga agcatcagtt gacagaggct gccgacacgt gcctcttccc tctcttctct 1980
gtcaccctcc tctggcggtc cttccacctt cctctgtcct ccggatgtcc tctttgcccg 2040
tcttctccct tggctgagca aagccatccc ctcaattcag ggaagggcaa ggagccttcc 2100
tcattcagga aatcaaatca gtcttccggt ctgcagcacg gaaaagcaca taatctttct 2160
ttgctgtgac tgaaatgtat ccctcgttta tcatcccctt tgtttgtgat tgctgctaaa 2220
gtcagtagta tcgttttttt aaaaaaaaag tttggtgttt ttaaccatgc tgttccagca 2280
aagatgatac cttaaactcc cactgcaagc ccatgaactt cccagagagt ggaacggctt 2340
gctcttcttt ctagaatgtc catgcacttg ggttttaatc agcagttccc tattattctg 2400
attttaagct gttcctgtga tgaacttaga gacagcatcg gtgtctgctg ctgtgtcccc 2460
aggtcttgtg tgggtggcac agatctgggc agttagatag tgctctgtgc ctaaggtgaa 2520
gccacactag ggtgaagcct cacttccctg tttgagcaat gcagtgcctg ctgcccgtgt 2580
gcatgaaggt acagccattc agataagtgg aactattgag ttacataaag aaaatagatt 2640
tgcatttgtc aggcagacgt ttatacaaca ccacggtgct tttatacatt gtgcttattt 2700
ataaaact gaaattct 2718
<210>14
<211>1840
<212>DNA
<213>人
<400>14
gcggcgcgag ccacatgcga gcgggcgcct ggcggcggcg gcggcggcac cagcgatccc 60
agcagcggcc acgacgcgga cgcgcctgcg gcccggggag cagcagcagc cacagccaca 120
gcagccgcca ctgcagttag agcggcagca gcagcgacag ccacagcagc agccgccgcg 180
gagagcggcg ctcggcgggc gcgccctcct gaaggaagcc gcccgccccc caccgccgcc 240
ccctccggcg tgttcatgcc cccggggccc cagggagcgc catggcccgc gcacgccagg 300
agggcagctc cccggagccc gtagagggcc tggcccgcga cggcccgcgc cccttcccgc 360
tcggccgcct ggtgccctcg gcagtgtcct gcggcctctg cgagcccggc ctggctgccg 420
cccccgccgc ccccaccctg ctgcccgctg cctacctctg cgcccccacc gccccacccg 480
ccgtcaccgc cgccctgggg ggttcccgct ggcctggggg tccccgcagc cggccccgag 540
gcccgcgccc ggacggtcct cagccctcgc tctcgctggc ggagcagcac ctggagtcgc 600
ccgtgcccag cgccccgggg gctctggcgg gcggtcccac ccaggcggcc ccgggagtcc 660
gcggggagga ggaacagtgg gcccgggaga tcggggccca gctgcggcgg atggcggacg 720
acctcaacgc acagtacgag cggcggagac aagaggagca gcagcggcac cgcccctcac 780
cctggagggt cctgtacaat ctcatcatgg gactcctgcc cttacccagg ggccacagag 840
cccccgagat ggagcccaat taggtgcctg cacccgcccg gtggacgtca gggactcggg 900
gggcaggccc ctcccacctc ctgacaccct ggccagcgcg ggggactttc tctgcaccat 960
gtagcatact ggactcccag ccctgcctgt cccgggggcg ggccggggca gccactccag 1020
ccccagccca gcctggggtg cactgacgga gatgcggact cctgggtccc tggccaagaa 1080
gccaggagag ggacggctga tggactcagc atcggaaggt ggcggtgacc gagggggtgg 1140
ggactgagcc gcccgcctct gccgcccacc accatctcag gaaaggctgt tgtgctggtg 1200
cccgttccag ctgcaggggt gacactgggg gggggggggc tctcctctcg gtgctccttc 1260
actctgggcc tggcctcagg cccctggtgc ttccccccct cctcctggga gggggcccgt 1320
gaagagcaaa tgagccaaac gtgaccacta gcctcctgga gccagagagt ggggctcgtt 1380
tgccggttgc tccagcccgg cgcccagcca tcttccctga gccagccggc gggtggtggg 1440
catgcctgcc tcaccttcat cagggggtgg ccaggagggg cccagactgt gaatcctgtg 1500
ctctgcccgt gaccgccccc cgccccatca atcccattgc ataggtttag agagagcgac 1560
gtgtgaccac tggcattcat ttggggggtg ggagattttg gctgaagccg ccccagcctt 1620
agtccccagg gccaagcgct ggggggaaga cggggagtca gggagggggg gaaatctcgg 1680
aagagggagg agtctgggag tggggaggga tggcccagcc tgtaagatac tgtatatgcg 1740
ctgctgtaga taccggaatg aattttctgt acatgtttgg ttaatttttt ttgtacatga 1800
tttttgtatg tttccttttc aataaaatca gattggaaca 1840
<210>15
<211>3093
<212>DNA
<213>人
<400>15
tagaatctgt tcaggaagtt ggaggttctt actggcaaag agtaactctc atcctggaat 60
tactgcagca caaaaagaag ctcagaagtc ctcagatatt ggtgccaact ctttttaact 120
tgctatcaag atgtttagaa cccttgccac aagagcaggg aaatatggaa tacaccaaac 180
aattaattct tagttgtctg ctcaacatct gccaaaaact atctccagat ggtggcaaaa 240
tacccaaaga tattttagat gaggagaagt tcaacgtgga gttgatagtt cagtgcatcc 300
gcctttcgga gatgccgcag acccatcacc atgccctttt acttttgggc actgttgctg 360
gaatatttcc ggataaagtt ttacacaata tcatgtctat ttttacattt atgggagcca 420
atgtcatgcg cctagatgat acttacagtt ttcaagttat taacaagaca gtgaaaatgg 480
ttattcccgc acttattcag tctgatagtg gagattctat agaagtttca agaaacgttg 540
aagagattgt ggtaaaaatc attagtgtat ttgtggatgc gctgccacac gtcccggagc 600
acaggcgcct gcccatcctt gttcaacttg ttgatacact gggtgcagag aaattcctct 660
ggattctcct catcttgctt tttgaacagt atgtcacaaa aacagtgctg gcggctgcct 720
atggcgaaaa ggatgctatt ttagaagcag acactgaatt ttggttttca gtctgttgtg 780
tttagtgt ccagcatcag atacaaagct tgatgaatat cctccagtac ttactaaagc 840
tgccagagga aaaagaagaa accattccca aagcagtgtc atttaataag agtgaatcac 900
aagaagaaat gctacaggtt tttaatgtag agactcacac tagcaagcaa ctgcggcatt 960
ttaaattttt gtcagtgtcc ttcatgtctc agctcctgtc ttccaatgat tttctgaaaa 1020
aggtagttga gagtggtggt cctgagattt taaaaggcct tgaagagagg ttgctggaga 1080
ccgttctcgg ctatatcagt gcagttgcac agtccatgga aaggaacgca gacaaactca 1140
ccgtgaagtt ctggcgcgcg ctccttagta aagcttacga cctgttagat aaggtcaatg 1200
ccttgctgcc cacagagaca ttcattcctg tgatcagagg gctggtgggc aatcccctgc 1260
catctgttcg ccgcaaagcg ctggaccttt tgaataacaa gctgcagcaa aatatatcct 1320
ggaagaagac aatagttacc cgtttcctaa aactggttcc agaccttttg gccattgtgc 1380
agcgtaagaa aaaggaaggg gaagaagaac aagcaatcaa cagacagaca gcgttgtata 1440
ccttaaagct tttatgcaag aattttggtg cagaaaatcc agatcctttt gtcccagtgc 1500
tgagcactgc tgtgaaactg attgctccag agagaaagga ggagaagaat gtcttgggaa 1560
gcgcgctgct gtgcatagca gaggtgacct ccaccctgga ggcgctggcc atcccccagc 1620
ttcccagcct gatgccatcg ttgctgacaa caatgaagaa caccagcgag ctggtctcca 1680
gcgaggtcta cctgctcagt gccttggctg ctctgcagaa ggttgtggag actctcccgc 1740
acttcatcag cccctatctg gaaggcattc tctcccaggt gattcatctg gagaaaatca 1800
ctagtgaaat gggttctgcg tcacgggcta atatccgtct cacatctctt aaaaagacac 1860
tggctaccac acttgcaccc cgagtcctgt tgcccgccat caaaaaaact tacaagcaga 1920
ttgagaagaa ctggaagaat cacatgggtc cgtttatgag catcttgcaa gagcatattg 1980
gggcgatgaa gaaggaagag ctcacctccc atcagtctca gctaaccgcc tttttcctgg 2040
aggccctgga cttccgagcc cagcactctg agaacgatct ggaggaagtt ggaaaaacgg 2100
aaaattgtat cattgactgt ctagtagcca tggttgtcaa actttccgag gtcacattca 2160
ggcccctgtt cttcaagctg tttgattggg ctaaaacaga agatgcccca aaggacaggt 2220
tgttgacatt ttacaacttg gcagattgca ttgctgaaaa gctgaaaggg ctttttactc 2280
tgtttgccgg ccacttagtg aagccttttg ctgacacctt ggaccaggtg aacatctcca 2340
aaacagatga agcatttttt gactctgaaa atgaccctga aaagtgctgc ttgctgttgc 2400
agtttatttt gaactgttta tacaaaatct tcctttttga tacccagcat tttataagta 2460
aagagagagc aggagccttg atgatgcctc tggtggatca gctggtaaac aggcttgggg 2520
gagaagagaa attccaggaa cgggtgacaa agcacctgat accatgcatc gcacagtttt 2580
cagtggccat ggcggatgac tctctttgga aaccactgaa ctaccagatt ctgctaaaga 2640
cgagagactc ctcgcctaag gttcgatttg ctgctttgat tactgtgtta gcactggctg 2700
aaaaactaaa ggagaattat attgtcttgc taccagaatc cattcctttc ttagcagagt 2760
tgatggaaga tgaatgtgaa gaagtagaac atcagtgcca aaagactatt cagcaactgg 2820
aaactgtcct gggagagcca ctccagagct atttctaaga ctttctgtgg tgtttcatac 2880
tctactcaga gttcacactc atatttcata tttttatttt tgggtgttgg gtgccatgtt 2940
acttttggtg ccttaataca cctacttgga ttacttacaa atgttttatc acttcgttac 3000
aaaatcccca cctggcttgt gctgccacat aagcctctcc tgcctatcgt atagagctgc 3060
gaaagagta aatgatacac ggtattttta tac 3093
<210>16
<211>1702
<212>DNA
<213>人
<400>16
caaaatccca ggcagcatgg acctcagtct tctctgggta cttctgcccc tagtcaccat 60
ggcctggggc cagtatggcg attatggata cccataccag cagtatcatg actacagcga 120
tgatgggtgg gtgaatttga accggcaagg cttcagctac cagtgtcccc aggggcaggt 180
gatagtggcc gtgaggagca tcttcagcaa gaaggaaggt tctgacagac aatggaacta 240
cgcctgcatg cccacgccac agagcctcgg ggaacccacg gagtgctggt gggaggagat 300
caacagggct ggcatggaat ggtaccagac gtgctccaac aatgggctgg tggcaggatt 360
ccagagccgc tacttcgagt cagtgctgga tcgggagtgg cagttttact gttgtcgcta 420
cagcaagagg tgcccatatt cctgctggct aacaacagaa tatccaggtc actatggtga 480
ggaaatggac atgatttcct acaattatga ttactatatc cgaggagcaa caaccacttt 540
ctctgcagtg gaaagggatc gccagtggaa gttcataatg tgccggatga ctgaatacga 600
ctgtgaattt gcaaatgttt agatttgcca cataccaaat ctgggtgaaa ggaaaggggc 660
cggggacagg agggtgtcca catatgttaa catcagttgg atctcctata gaagtttctg 720
gctctctt tccttctccc tgagctggta actgcaatgc caacttcctg ggcctttctg 780
actagtatca cacttctaat aaaatccaca attaaaccat gtttctcact tttcacatgt 840
ttcatagcaa ctgctttata tgactgatga tggcttcctt gcacaccaca tatacagtgc 900
gcatgcttac agccgggctt ctggagcacc agctgcagcc tggctactgc tttttactgc 960
agaatgaact gcaagttcag catagtggag gggagaggca gaactggagg agaggtgcag 1020
tgaaggttct ctacagctaa gcctgtttga atgatacgta ggttccccac caaaagcagg 1080
ctttctgccc tgagggacat cttcccactc ccctgctcca catgagccat gcatgcttag 1140
caatccaagt gcagagctct ttgctccagg agtgaggaga ctgggaggtg aaatggggaa 1200
atggaagggt ttggaggcag agctgaaaac agggttggaa ggatttcctg aattagaaga 1260
caaacgttag catacccagt aaggaaaatg agtgcagggg ccaggggaac ccgtgaggat 1320
actctcaaa tgagattaaa aacaaggaag cagagaatgg tcagagaatg ggattcagat 1380
tgggaacttg tggggatgag agtgaccagg ttgaactggg aagtggaaaa aggagtttga 1440
gtcactggca cctagaagcc tgcccacgat tcctaggaag gctggcagac accctggaac 1500
cctggggagc tactggcaaa ctctcctgga ttgggcctga tttttttggt gggaaaggct 1560
gccctgggga tcaactttcc ttctgtgtgt ggctcaggag ttcttctgca gagatggcgc 1620
tatctttcct cctcctgtga tgtcctgctc ccaaccattt gtactcttca ttacaaaaga 1680
aataaaaata ttaacgttca ct 1702
<210>17
<211>2730
<212>DNA
<213>人
<400>17
agaatgccta tgagacacag gaagaaggca gcagacaaga atcttccctg ccgtccttta 60
gtatgtgcag tactggacct gatggtagag tttattgtaa cacacatgat gaaggagttt 120
cctatggatc tctatatacg ctgcatccag gtagtacaca aactgctctg ctaccagaag 180
aagtgtcggg tacgcctgca ttacacctgg cgggagctct ggtcagcctt gataaatttg 240
ctgaagttcc ttatgtcaaa tgagactgta cttttggcca aacacaacat ttttacatta 300
gcccttatga ttgtgaacct atttaatatg tttatcacat atggcgacac atttctgcca 360
ccccagca gctatgatga actttactat gagattatcc gcatgcacca gagctttgac 420
aacctctact ccatggtcct gaggctttct accaatgcag gccagtggaa ggaagcagct 480
agcaaggtga cccatgcatt ggttaatatc agagccatca tcaaccactt taaccccaaa 540
attgagtcct acgctgctgt gaatcacata tcccaactgt cagaggagca ggtgctggag 600
gtggtgagag ccaactatga cacgctcacg ctgaagctgc aggatggcct ggaccagtat 660
gagcgctact cagagcagca caaggaagct gccttcttca aagagctggt tcgatccatt 720
agcaccaacg tccggagaaa cctggtcttc cacacactca gccaagaagt cctgctcaag 780
gagttctcca ctatctcctg aggccacgcc tacctgagca gcctctgact gcccttaccc 840
atgaggatca tgggctggag ggggagcgag gggagagggg gctgcccccg aggttggaga 900
aaacacaga taccaagttc tcttggtgaa gaccgcactt caatggagct tgggcagcag 960
gggcaggagg gtcaagccag ggataatctt atttggggag gaatgggtgg gcacagtggg 1020
gagaggcctc caggaatgtg gggacttcca gagtgggctc cctaaacagc ccctcacatt 1080
tccaatcttg aggttacaag ctgtagctac tgactaattt tcgggagctg gtgaggcaag 1140
cctcagggta atgccagcac cctgaaagtc agtggctctg ctcggcttct gaaaacagat 1200
caactctcag atatagctgg agctacatcc tgcttccttt gggcctgggg ctgtgcttgg 1260
cttgaaatct gtgtcccctg cctgcactgg cactttgtcc agtcatcggg acctttggct 1320
cagatttagg gtaagatagg aatagggtac ctttttcctt ttttttctga gacggagtct 1380
cactctgtcg cccaggctgg aatgcagtgg cgtgatctcg gctttactgc agcctccgct 1440
tcctgggttc aagcgattct cctgcctcag cctcccgagt agctgggact acaggagcgt 1500
gtgccacgcc cggctaattt tttgtatttt tagtagagat ggagtttcac catgttaccc 1560
aggatggtct caatatcctg agttcatgat ccacccacct tggcctccca aagtgctggg 1620
attacaggcg tgagccacca cacccagcca gttttcctat tttctgaatt cagaattgac 1680
ttctctggga aaactggaga tgagaatctg cccagtgctc tgctgtccag tcaccgcctt 1740
ttgaatttta gttttggcac caggagtacc gttagctttc cccttcttct ggcccatttg 1800
actcatcagc acaatagggt caccacctta acttttaatt tctaatctgc tttactgtct 1860
ttagggtgtg tatgaaataa acattgacag gctttctgga gccctcaagg tgcctacttt 1920
gctggttccc tttccagcag ctcccccacc tcccttagcc ccccctcctc tggcagcctc 1980
tcctgcctct gctgagctcc cctccacgtg ttccaccccc ttaccctgct gttgtttaca 2040
caacctgc ctgagaattt cctctgggga ggaatctatt cctgtcatgg tctagtgcct 2100
gggagggaga gaacttcctg ggggtagggt gccctccatc tgaaacaggc caggtgagca 2160
tcatgcataa ggcctccatt ctgtccgctc agattctggg tggggccaca ggcaaatctc 2220
ctgacttatg gggagttggc ttgtggttcc tcccttggat agcctccatg gaaccactat 2280
aggctttccc aacagctgcc tctgaaatag ctgctgcttc gagatcctcc ctttttaaag 2340
cactttctaa agccctcagg atggcgggag caaacagcac tggtatattc taggagtaag 2400
tgcaggaatt cagcagtgag agcatgtctg ggaccacctg gactgccatc catttaacct 2460
caaatctctt tgggatactc gccctccctg ggaaccagag ttctggctct aacattgagc 2520
agctatgcac tagttccaga gaagccacta acaggctgcc atgtgtagat gtaggttctt 2580
aagagatcac aggctgggtc atctgatcac tggatggata gctcagcctg gggcatttag 2640
ttttccct ggtgataaat ccccaaggca gctggatttg gagctggtgg caagttgaaa 2700
ttattaaaaa ttgatttgtg tgggactgtc 2730
<210>18
<211>1972
<212>DNA
<213>人
<400>18
aggggttggc cctggagtct gccagccaca ctgggaaaac attggagctt ggtctgccat 60
cctgaactgt ggttcccctg cctcccagcc cggctgtgag tgctcagcga ccctgacagg 120
ctgacagttg ggccatatgg tgctcttccc agtctggttc ctgtacagtc tgctcatgaa 180
gctgttccag cgctccacgc cagccatcac cctcgagagc ccggacatca agtacccgct 240
gcggctcatc gaccgggaga tcatcagcca tgacacccgg cgcttccgct ttgccctgcc 300
gtcaccccag cacatcctgg gcctccctgt cggccagcac atctacctct cggctcgaat 360
tgatggaaac ctggtcgtcc ggccctatac acccatctcc agcgatgatg acaagggctt 420
cgtggacctg gtcatcaagg tttacttcaa ggacacccat cccaagtttc ccgctggagg 480
gaagatgtct cagtacctgg agagcatgca gattggagac accattgagt tccggggccc 540
cagtgggctg ctggtctacc agggcaaagg gaagttcgcc atccgacctg acaaaaagtc 600
caaccctatc atcaggacag tgaagtctgt gggcatgatc gcgggaggga caggcatcac 660
cgatgctg caggtgatcc gcgccatcat gaaggaccct gatgaccaca ctgtgtgcca 720
cctgctcttt gccaaccaga ccgagaagga catcctgctg cgacctgagc tggaggaact 780
caggaacaaa cattctgcac gcttcaagct ctggtacacg ctggacagag cccctgaagc 840
ctgggactac ggccagggct tcgtgaatga ggagatgatc cgggaccacc ttccaccccc 900
agaggaggag ccgctggtgc tgatgtgtgg ccccccaccc atgatccagt acgcctgcct 960
tcccaacctg gaccacgtgg gccaccccac ggagcgctgc ttcgtcttct gagggccggg 1020
cacggtcaca cggccacccg ccccgcgcac cccacgccct gttcacgctc acccagtcac 1080
ctccccacat cgcacactgg ggccccgggt tcagcctggc ctgcccgtgc cctggtgaat 1140
cacctggctg agcagttccc ctggagcccc ttcgggagca gggctgtgtc ccagatgggc 1200
acggctgag ccttcagagt acgtcctgcc tggcacttac tggtccttac cagagacgcc 1260
cagccccatc cctgtcctca tgacccctcg tccacccccc acacacacta taaggctgag 1320
ggctgccagc agccccgtct gcccaccatt cccggccgtg gaccatagtc gggatgtcag 1380
cagacacaca tgggcagccc aaagctgcag gtgccagggc ccaccccagc ctcgcctgtc 1440
acccccactc ccgcctcagg gccaggccca ggcctcacca cctgacgctg catgagacat 1500
tgacaccaga aagccctctt gggggcactg ctccctaccc cagggccctg gccagccggg 1560
agcttggctc tcctctggct agagtgggaa gagggggctg gccatggggc cctcccagaa 1620
cctcagcatt tccttccagc ccatccaaac actgaggcag ccttggggaa ccccgagctg 1680
gggggttggc agcccactgc accgcctcag ggttttgggg tcctgggctg gggccaccat 1740
ccctgatggc agaactccca caaccacatg tatttattcc tctgtcctaa accgtcccct 1800
ccttccctca cccccagcac agggggattc tgagcagtgc ctcttgtctg agggacatat 1860
cagtgacctc gacgttgcct ttagactaca gttgtgttag cctcttgcgt attggctttt 1920
tcagagtcat ttatgagcag aaaaaaaaaa agtaaaactt tgctaatatt aa 1972
<210>19
<211>1852
<212>DNA
<213>人
<400>19
cgcgcgac tttttgaaag ccaggagggt tcgaattgca acggcagctg ccgggcgtat 60
gtgttggtgc tagaggcagc tgcagggtct cgctgggggc cgctcgggac caattttgaa 120
gaggtacttg gccacgactt attttcacct ccgacctttc cttccaggcg gtgagactct 180
ggactgagag tggctttcac aatggaaggg atcagtaatt tcaagacacc aagcaaatta 240
tcagaaaaaa agaaatctgt attatgttca actccaacta taaatatccc ggcctctccg 300
tttatgcaga agcttggctt tggtactggg gtaaatgtgt acctaatgaa aagatctcca 360
agaggtttgt ctcattctcc ttgggctgta aaaaagatta atcctatatg taatgatcat 420
tatcgaagtg tgtatcaaaa gagactaatg gatgaagcta agattttgaa aagccttcat 480
catccaaaca ttgttggtta tcgtgctttt actgaagcca atgatggcag tctgtgtctt 540
gctatggaat atggaggtga aaagtctcta aatgacttaa tagaagaacg atataaagcc 600
gccaagatc cttttccagc agccataatt ttaaaagttg ctttgaatat ggcaagaggg 660
ttaaagtatc tgcaccaaga aaagaaactg cttcatggag acataaagtc ttcaaatgtt 720
gtaattaaag gcgattttga aacaattaaa atctgtgatg taggagtctc tctaccactg 780
gatgaaaata tgactgtgac tgaccctgag gcttgttaca ttggcacaga gccatggaaa 840
cccaaagaag ctgtggagga gaatggtgtt attactgaca aggcagacat atttgccttt 900
ggccttactt tgtgggaaat gatgacttta tcgattccac acattaatct ttcaaatgat 960
gatgatgatg aagataaaac ttttgatgaa agtgattttg atgatgaagc atactatgca 1020
gcgttgggaa ctaggccacc tattaatatg gaagaactgg atgaatcata ccagaaagta 1080
attgaactct tctctgtatg cactaatgaa gaccctaaag atcgtccttc tgctgcacac 1140
attgttgaag ctctggaaac agatgtctag tgatcatctc agctgaagtg tggcttgcgt 1200
aaataactgt ttattccaaa atatttacat agttactatc agtagttatt agactctaaa 1260
attggcatat ttgaggacca tagtttcttg ttaacatatg gataactatt tctaatatga 1320
aatatgctta tattggctat aagcacttgg aattgtactg ggttttctgt aaagttttag 1380
aaactagcta cataagtact ttgatactgc tcatgctgac ttaaaacact agcagtaaaa 1440
cgctgtaaac tgtaacatta aattgaatga ccattacttt tattaatgat ctttcttaaa 1500
tattctatat tttaatggat ctactgacat tagcactttg tacagtacaa aataaagtct 1560
acatttgttt aaaacactga accttttgct gatgtgttta tcaaatgata actggaagct 1620
gaggagaata tgcctcaaaa agagtagctc cttggatact tcagactctg gttacagatt 1680
gtcttgatct cttggatctc ctcagatctt tggtttttgc tttaatttat taaatgtatt 1740
ccatactg agtttaaaat ttattaattt gtaccttaag catttcccag ctgtgtaaaa 1800
acaataaaac tcaaatagga tgataaagaa taaaggacac tttgggtacc ag 1852
<210>20
<211>2883
<212>DNA
<213>人
<400>20
ccgggtgggc tccaggcggc cggtccccgg cctcccccca tggccaccgc cccctcttat 60
ccgccgggc tccctggctc tcccgggccg gggtctcctc cgccccccgg cggcctagag 120
ctgcagtcgc cgccaccgct actgccccag atcccggccc cgggttccgg ggtctccttt 180
cacatccaga tcgggctgac ccgcgagttc gtgctgttgc ccgccgcctc cgagctggct 240
catgtgaagc agctggcctg ttccatcgtg gaccagaagt tccctgagtg tggcttctac 300
ggcctttacg acaagatcct gcttttcaaa catgacccca cgtcggccaa cctcctgcag 360
ctggtgcgct cgtccggaga catccaggag ggcgacctgg tggaggtggt gctgtcggcc 420
tcggccacct tcgaggactt ccagatccgc ccgcacgccc tcacggtgca ctcctatcgg 480
gcgcctgcct tctgtgatca ctgcggggag atgctcttcg gcctagtgcg ccagggcctc 540
aagtgcgatg gctgcgggct gaactaccac aagcgctgtg ccttcagcat ccccaacaac 600
tgtagtgggg cccgcaaacg gcgcctgtca tccacgtctc tggccagtgg ccactcggtg 660
cgcctcggca cctccgagtc cctgccctgc acggctgaag agctgagccg tagcaccacc 720
gaactcctgc ctcgccgtcc cccgtcatcc tcttcctcct cttctgcctc atcgtatacg 780
ggccgcccca ttgagctgga caagatgctg ctctccaagg tcaaggtgcc gcacaccttc 840
ctcatccaca gctatacacg gcccaccgtt tgccaggctt gcaagaaact cctcaagggc 900
ctcttccggc agggcctgca atgcaaagac tgcaagttta actgtcacaa acgctgcgcc 960
acccgcgtcc ctaatgactg cctgggggag gcccttatca atggagatgt gccgatggag 1020
gaggccaccg atttcagcga ggctgacaag agcgccctca tggatgagtc agaggactcc 1080
ggtgtcatcc ctggctccca ctcagagaat gcgctccacg ccagtgagga ggaggaaggc 1140
gagggaggca aggcccagag ctccctgggg tacatccccc taatgagggt ggtgcaatcg 1200
gcgacaca cgacgcggaa atccagcacc acgctgcggg agggttgggt ggttcattac 1260
agcaacaagg acacgctgag aaagcggcac tattggcgcc tggactgcaa gtgtatcacg 1320
ctcttccaga acaacacgac caacagatac tataaggaaa ttccgctgtc agaaatcctc 1380
acggtggagt ccgcccagaa cttcagcctt gtgccgccgg gcaccaaccc acactgcttt 1440
gagatcgtca ctgccaatgc cacctacttc gtgggcgaga tgcctggcgg gactccgggt 1500
gggccaagtg ggcagggggc tgaggccgcc cggggctggg agacagccat ccgccaggcc 1560
ctgatgcccg tcatccttca ggacgcaccc agcgccccag gccacgcgcc ccacagacaa 1620
gcttctctga gcatctctgt gtccaacagt cagatccaag agaatgtgga cattgccact 1680
gtctaccaga tcttccctga cgaagtgctg ggctcagggc agtttggagt ggtctatgga 1740
ggaaaacacc ggaagacagg ccgggacgtg gcagttaagg tcattgacaa actgcgcttc 1800
cctaccaagc aggagagcca gctccggaat gaagtggcca ttctgcagag cctgcggcat 1860
cccgggatcg tgaacctgga gtgcatgttc gagacgcctg agaaagtgtt tgtggtgatg 1920
gagaagctgc atggggacat gttggagatg atcctgtcca gtgagaaggg ccggctgcct 1980
gagcgcctca ccaagttcct catcacccag atcctggtgg ctttgagaca ccttcacttc 2040
aagaacattg tccactgtga cttgaaacca gaaaacgtgt tgctggcatc agcagaccca 2100
tttcctcagg tgaagctgtg tgactttggc tttgctcgca tcatcggcga gaagtcgttc 2160
cgccgctcag tggtgggcac gccggcctac ctggcacccg aggtgctgct caaccagggc 2220
tacaaccgct cgctggacat gtggtcagtg ggcgtgatca tgtacgtcag cctcagcggc 2280
accttccctt tcaacgagga tgaggacatc aatgaccaga tccagaacgc cgccttcatg 2340
tacccggcca gcccctggag ccacatctca gctggagcca ttgacctcat caacaacctg 2400
ctgcaggtga agatgcgcaa acgctacagc gtggacaaat ctctcagcca cccctggtta 2460
caggagtacc agacgtggct ggacctccga gagctggagg ggaagatggg agagcgatac 2520
atcacgcatg agagtgacga cgcgcgctgg gagcagtttg cagcagagca tccgctgcct 2580
gggtctgggc tgcccacgga cagggatctc ggtggggcct gtccaccaca ggaccacgac 2640
atgcaggggc tggcggagcg catcagtgtt ctctgaggtc ctgtgccctc gtccagctgc 2700
tgccctccac agcggttctt cacaggatcc cagcaatgaa ctgttctagg gaaagtggct 2760
tcctgcccaa actggatggg acacgtgggg agtggggtgg ggggagctat ttccaaggcc 2820
cctccctgtt tccccagcaa ttaaaacgga ctcatctctg gccccatggc cttgatctca 2880
gca 2883
<210>21
<211>1463
<212>DNA
<213>人
<400>21
cgcccctgac accattcctc ccttcccccc tccaccggcc gcgggcataa aaggcgccag 60
gtgagggcct cgccgctcct cccgcgaatc gcagcttctg agaccagggt tgctccgtcc 120
gtgctccgcc tcgccatgac ttcctacagc tatcgccagt cgtcggccac gtcgtccttc 180
ggaggcctgg gcggcggctc cgtgcgtttt gggccggggg tcgcctttcg cgcgcccagc 240
attcacgggg gctccggcgg ccgcggcgta tccgtgtcct ccgcccgctt tgtgtcctcg 300
tcctcctcgg gggcctacgg cggcggctac ggcggcgtcc tgaccgcgtc cgacgggctg 360
ctggcgggca acgagaagct aaccatgcag aacctcaacg accgcctggc ctcctacctg 420
gacaaggtgc gcgccctgga ggcggccaac ggcgagctag aggtgaagat ccgcgactgg 480
taccagaagc aggggcctgg gccctcccgc gactacagcc actactacac gaccatccag 540
gacctgcggg acaagattct tggtgccacc attgagaact ccaggattgt cctgcagatc 600
gacaatgccc gtctggctgc agatgacttc cgaaccaagt ttgagacgga acaggctctg 660
cgcatgagcg tggaggccga catcaacggc ctgcgcaggg tgctggatga gctgaccctg 720
gccaggaccg acctggagat gcagatcgaa ggcctgaagg aagagctggc ctacctgaag 780
aagaaccatg aggaggaaat cagtacgctg aggggccaag tgggaggcca ggtcagtgtg 840
gaggtggatt ccgctccggg caccgatctc gccaagatcc tgagtgacat gcgaagccaa 900
tatgaggtca tggccgagca gaaccggaag gatgctgaag cctggttcac cagccggact 960
gaagaattga accgggaggt cgctggccac acggagcagc tccagatgag caggtccgag 1020
gttactgacc tgcggcgcac ccttcagggt cttgagattg agctgcagtc acagctgagc 1080
atgaaagctg ccttggaaga cacactggca gaaacggagg cgcgctttgg agcccagctg 1140
gcgcatatcc aggcgctgat cagcggtatt gaagcccagc tgggcgatgt gcgagctgat 1200
agtgagcggc agaatcagga gtaccagcgg ctcatggaca tcaagtcgcg gctggagcag 1260
gagattgcca cctaccgcag cctgctcgag ggacaggaag atcactacaa caatttgtct 1320
ctccaagg tcctctgagg cagcaggctc tggggcttct gctgtccttt ggagggtgtc 1380
ttctgggtag agggatggga aggaagggac ccttaccccc ggctcttctc ctgacctgcc 1440
aataaaaatt tatggtccaa ggg 1463
<210>22
<211>2309
<212>DNA
<213>人
<400>22
cgcgctggag aggcgcgggg tcaagacgtc cggcctcggg ggcccgggct gggccgccga 60
gtcccctggg cggcgctgag cgggcgggag gcgggggccc gcggctcggg gcaaccgagg 120
ccgggtcgcg ggatcggccg ccatcgccgc cgccgctgca ctgggagccc gcggggatgg 180
agcgggaggc gttgccgtgg ggcctcgagc cccaggatgt gcagagttct gacgaaatga 240
ggagccccga agggtacctc agaggcaaca tgagtgagaa tgaggaagag gaaatttctc 300
agcaagaagg cagtggggac tatgaagtcg aagagatacc atttgggctt gaaccccaga 360
gccctgggtt tgagccacaa agcccagagt ttgaacccca aagccccaga tttgagcctg 420
aaagcccggg gtttgagtcc cgaagccctg ggcttgtgcc cccaagccct gagtttgcac 480
ccagaagccc tgaatcagat tctcagagcc ctgagtttga atcccagagc cctaggtatg 540
aaccccaaag ccctggctat gaacctcgga gccccgggta tgaaccccgg agccctggct 600
atgaatctga gagctctaga tatgaatccc agaacactga gctcaaaacc caaagcccag 660
aatttgaagc tcaaagttcc aaattccagg aaggtgcgga gatgcttctg aaccccgacg 720
aaaagagtcc tttgaatatc tccgtaggag ttcaccccct ggactccttc actcaggggt 780
ttggggagca gcccacaggg gacctgccca tagggccacc ttttgagatg cccacagggg 840
ccctgctgtc tacaccgcag tttgagatgc ttcagaatcc cctgggtctc acaggagccc 900
ttcgaggtcc aggtcggcgg ggtggccggg ccaggggtgg gcagggccct cggcctaaca 960
tctgcggcat ctgcgggaag agcttcgggc ggggctccac cctgatccag caccagcgca 1020
tccacaccgg tgagaagccc tacaaatgtg aggtctgcag caaggccttc tcccagagct 1080
ctgacctcat caaacaccag cgcacccaca ctggcgagcg gccctacaaa tgtccccgtt 1140
gcggcaaggc cttcgccgac agctcttacc tgcttcgcca ccagcgcact cactctggcc 1200
aagcccta caagtgccca cattgtggca aggccttcgg cgacagctcc tacctcctgc 1260
gacaccagcg cacccacagc cacgagcggc cctacagctg caccgagtgc ggcaagtgct 1320
atagccagaa ctcgtccctg cgcagccatc agagggtgca caccggtcag aggcccttca 1380
gctgtggcat ctgcggcaag agcttctccc agcggtcggc ccttatcccc catgcccgca 1440
gccacgcccg ggagaagccc ttcaagtgcc ctgagtgcgg caagcgcttt ggccagagct 1500
cggtgctggc catccacgcc cgcacccacc tgccaggccg cacctacagc tgccccgact 1560
gcggcaagac cttcaatcgc tcctccactc tcatccagca ccagcgctcc cacacgggcg 1620
agcggcccta caggtgcgcc gtgtgcggca agggcttctg ccgctcctcc acgcttctgc 1680
agcatcaccg ggtccacagt ggcgagcggc cttacaagtg cgatgactgc ggaaaggcct 1740
ctcccagag ctccgacctc atccgccacc agcggaccca cgcggcgggc cggcgctgac 1800
ctggggcccc agcaggggtg ggaggtgtgg gcagaagata aggggccagg gagctagagg 1860
aacctttagg gaggatagtg gagaagccgc aggagaatgg aggagctgag gatgctggaa 1920
gaagagaacc agggtggagg aagtgacatg ccctggagac ttgtgggaag tgggttggag 1980
ggaggccagg ccggcagcgg gaggccctgg gagaaatgga gagaggtcag cggagggctg 2040
gcctcagccg cggctccttg gtgggtgcct ggcttggcaa ctgctagagc agggaggggg 2100
gagggcaggg gattacctaa ttagagtggg ttagcttaga ttggtagctg ctgaaactct 2160
cgttgagtca ggagcgggta aaaggtaggt ggggtgggga gtggggcccc ggggtggggc 2220
ctgggcctct gcgtgcaaac cccagcctcc ctcttcttcc tcaggctttg gagcccctga 2280
gtttgagttc aataaaaact ttatgtggt 2309
<210>23
<211>1853
<212>DNA
<213>人
<400>23
cacagggact gcgctccctt gcccctagcg ctcccgcgct gctgctccag ccgcccggca 60
gctctgagga tggagaggag ggcgcggagc tcctccaggg agtcccgcgg gcgaggcggc 120
aggactccgc acaaggagaa caagagggca aaggccgaga ggagcggcgg gggccgcggg 180
ccaggagg ctgggcccga gccgtcgggc tccggacggg cggggacccc gggggagccc 240
cgagcgcccg ccgccacggt ggtggacgtg gatgaggtcc gaggctccgg cgaggagggc 300
accgaggtgg tggcgctgtt ggagagcgag cggcccgagg aaggtaccaa atcctccggc 360
ttaggggcct gtgagtggct tcttgtcctc atttccctgc tcttcatcat catgaccttc 420
cctttttcca tctggttctg cgtaaaggtt gtacaagagt atgaaagagt aattatattc 480
cgactgggac atctgcttcc tggaagagcc aaaggccctg gtcttttctt ttttttgccc 540
tgcctggata cctaccacaa ggttgacctt cgtctccaaa ctctggagat accttttcat 600
gagatcgtga ccaaagacat gtttataatg gagatagatg ccatttgcta ctaccgaatg 660
gaaaatgcct ctcttctcct aagcagtctt gctcatgtat ctaaagctgt gcaattcctt 720
gtgcaaacca ctatgaagcg tctcctagca catcgatccc tcactgaaat tcttctagag 780
gaagagca tcgcccaaga tgcaaaggtt gccttggatt cagtgacctg tatttgggga 840
atcaaagtgg agagaataga aattaaagat gtgaggttgc cagctgggct tcagcactca 900
ctggctgtgg aggctgaagc gcaaagacaa gccaaagtgc ggatgattgc tgcagaagcg 960
gaaaaggctg cttctgagtc cctgaggatg gcagctgaga ttctgtcagg cacccctgct 1020
gctgttcagc ttcgatacct ccacaccctt cagtctctgt ccacagagaa gccttccact 1080
gtggttttac ctttgccatt tgacctactg aattgcctgt cttctcccag caacagaact 1140
cagggaagcc tccccttccc aagtccttcc aaacctgttg agccactaaa tcctaaaaag 1200
aaagactctc ccatgttata ggaaggatgg ggcataatgt gactgtaaag gggcctgcca 1260
tagaaaagtc acatccctga gggagacact ctgtcctcat tccctgccct tcctttggtt 1320
gccatatgga atggccatgg aatgcacgaa gtcacaatgc accatccatg agaagacagt 1380
gaaatgatgt aatgacagag aaggcagaca acatgtttcc gtgactcatc tagtcagagc 1440
aattatggga aacagctttg gtcaacattc tactttggaa agaattttga gtctagatgt 1500
ggttaaattt tgacttctgg gaacttggtt cagatgtccc tttcactgta tgtcctctga 1560
cccctttggc aaggttgcca cagctcccac agcccttcct acaagcacct atcattgggc 1620
ttgtcacact ctattgctct tctgtcccga agatgcagtc ttctctccaa tgatactacc 1680
aagtcttagt tttcctcaac cacactcaat ctttttgctc caccctgaat tcctcacacc 1740
taaccctgat agttacctaa agtgacactt aaatgtttca gagtgaatgc aaaaaagaga 1800
gatgtacttg gagtcggata tacaatttat ccctaattaa agcatttaaa agg 1853
<210>24
<211>765
<212>DNA
<213>人
<400>24
ggcaagcact ttaacctttt aagcccaacc agatgagttg cctgcagttt tggaggcctt 60
cagagcattt cactagacct ctgtctgtgt cggtccagtg tctttagcca agctttgatt 120
aaagatgact tccttgtttg ctcaagaaat tcgcctttct aaaagacatg aagaaatagt 180
atcacaaaga ttaatgttac ttcaacaaat ggagaataaa ttgggtgatc aacacacaga 240
aaaggcatct caactccaaa ctgttgagac tgcttttaaa aggaacctta gtcttttaaa 300
ggatatagaa gcagcagaaa agtcactaca gaccaggatt cacccacttc cacggcctga 360
ggtggtttct cttgagactc gttactgggc atcagtagaa gaatatattc ccaaatggga 420
acagtttctt ttaggaagag caccatatcc ttttgctgtt gaaaatcaaa atgaagcaga 480
aaataccatt caaaatgagg cacagcgata acttcttcac atgctatttc aaaaagcctg 540
tttaataaag ctgaatgtta aggtgtatgt aggttattgc aggaacttta ggaattaaat 600
atgttcatat tcttcgatta tctcctaagt gacagtgaag atatgagaat ttactggcaa 660
gtcacatgtt atcacctact actatttcaa ggtcatgaat ttgctttcta ccaaacccat 720
agatgtgtta aacacgaata ttaaaaggtg gactctttat taatt 765
<210>25
<211>2448
<212>DNA
<213>人
<400>25
acgtcccagc gtctgagaga acgagtaagc acagaattca aagcattctg cagcctgaat 60
tttgaaggag tgtgtttagg cactaagcaa gctgatttat gataactgct ttaaacttca 120
acaaccaaag gcataagaac taggagctgc tgacatttca atatgaaggg caactccacc 180
cttgccacta ctagcaaaaa cattaccagc ggtcttcact tcgggcttgt gaacatctct 240
ggcaacaatg agtctacctt gaactgttca cagaaaccat cagataagca tttagatgca 300
attcctattc tttactacat tatatttgta attggatttc tggtcaatat tgtcgtggtt 360
acactgtttt gttgtcaaaa gggtcctaaa aaggtttcta gcatatacat cttcaacctc 420
gctgtggctg atttactcct tttggctact cttcctctat gggcaaccta ttattcttat 480
agatatgact ggctctttgg acctgtgatg tgcaaagttt ttggttcttt tcttaccctg 540
aacatgtttg caagcatttt ttttatcacc tgcatgagtg ttgataggta ccaatctgtc 600
atctacccct ttctgtctca aagaagaaat ccctggcaag catcttatat agttcccctt 660
gtttggtgta tggcctgttt gtcctcattg ccaacatttt attttcgaga cgtcagaacc 720
attgaatact taggagtgaa tgcttgcatt atggctttcc cacctgagaa atatgcccaa 780
tggtcagctg ggattgcctt aatgaaaaat atccttggtt ttattatccc tttaatattc 840
tagcaacat gctattttgg aattagaaaa cacttactga agacgaatag ctatgggaag 900
aacaggataa cccgtgacca agtcctgaag atggcagctg ctgttgttct ggccttcatc 960
atttgctggc ttcccttcca tgttctgacc ttcctggatg ctctggcctg gatgggtgtc 1020
attaatagct gcgaagttat agcagtcatt gacctggcac ttccttttgc catcctcttg 1080
ggattcacca acagctgcgt taatccgttt ctgtattgtt ttgttggaaa ccggttccaa 1140
cagaagctcc gcagtgtgtt tagggttcca attacttggc tccaagggaa aagagagagt 1200
atgtcttgcc ggaaaagcag ttctcttaga gaaatggaga cctttgtgtc ttaaacgtga 1260
gagcaaaatg catgtaatca acatggctac ttgctttgag gctcaccaga attattttta 1320
agtggtttta ataaaataat aaaatttccc ctaatctttt ctgaatcttc tgaaaccaaa 1380
tgtaactatg ttttatcgtc cagtgacttt caggaattgc ccattgtttt tctgatatgt 1440
ttgtacaaga tttcattggt gagacatatt tacaacctag aagtaactgg tgatatatct 1500
caaattgtaa ttaataatag attgtgaata atgatttggg gattcagatt tctctttgaa 1560
acatgcttgt gtttcttagt ggggttttat atccattttt atcaggattt cctcttgaac 1620
cagaaccagt ctttcaactc attgcatcat ttacaagaca acattgtaag agagatgagc 1680
acttctaagt tgagtatatt ataatagatt agtactggat tattcaggct ttaggcatat 1740
gcttctttaa aaacgctata aattatattc ctcttgcatt tcacttgagt ggaggtttat 1800
agttaatcta taactacata ttgaataggg ctaggaatat agattaaatc atactcctat 1860
gctttagctt atttttacag ttatagaaag caagatgtac tataacatag aattgcaatc 1920
tataatattt gtgtgttcac taaactctga ataagcactt tttaaaaaac tttctactca 1980
ttaatgat tgtttaaagg tttctatttt ctctgatact tttttgaaat cagtaaacac 2040
tgtgtattgt tgtaaaatgt aaaggtcact tttcacatcc ttgacttttt agatgtgctg 2100
ctttgatata taggacattg atttgatttt tattattaat gctttggttc tgggttgttt 2160
cctaaaatat ctgggtggct taaaaaaaac tctttaactt gtaataaacc cttaactggc 2220
ataggaaatg gtatccagaa tggaattttg ctacatgggg tctgggtggg ggcaaagaga 2280
cccagtcaat tacatgtttg gtaccaagaa aggaacctgt cagggcagta caatgtgact 2340
ttgaaaatat ataccgtggg ggtagtttta ccctatatct ataaacactg tttgttccag 2400
aatctgtatg attctatgga gctattttaa accaattgca ggtctaga 2448
<210>26
<211>1101
<212>DNA
<213>人
<400>26
atggatttct taaattcatc tgatcaaaac ttgacctcag aggaactgtt aaacagaatg 60
ccatccaaaa ttctggtgtc cctcactctg tctgggctgg cactgatgac aacaactatc 120
aactcccttg tgatcgctgc aattattgtg acccggaagc tgcaccatcc agccaattat 180
ttaatttgtt cccttgcagt cacagatttt cttgtggctg tcctggtgat gcccttcagc 240
attgtgtata ttgtgagaga gagctggatt atggggcaag tggtctgtga catttggctg 300
agtgttgaca ttacctgctg cacgtgctcc atcttgcatc tctcagctat agctttggat 360
cggtatcgag caatcacaga tgctgttgag tatgccagga aaaggactcc aaagcatgct 420
ggcattatga ttacaatagt ttggattata tctgttttta tctctatgcc tcctctattc 480
tggaggcacc aaggaactag cagagatgat gaatgcatca tcaagcacga ccacattgtt 540
tccaccattt actcaacatt tggagctttc tacatcccac tggcattgat tttgatcctt 600
tactacaaaa tatatagagc agcaaagaca ttataccaca agagacaagc aagtaggatt 660
gcaaaggagg aggtgaatgg ccaagtcctt ttggagagtg gtgagaaaag cactaaatca 720
gtttccacat cctatgtact agaaaagtct ttatctgacc catcaacaga ctttgataaa 780
attcatagca cagtgagaag tctcaggtct gaattcaagc atgagaaatc ttggagaagg 840
aaagatct caggtacaag agaacggaaa gcagccacta ccctgggatt aatcttgggt 900
gcatttgtaa tatgttggct tccttttttt gtaaaagaat tagttgttaa tgtctgtgac 960
aaatgtaaaa tttctgaaga aatgtccaat tttttggcat ggcttgggta tctcaattcc 1020
cttataaatc cactgattta cacaatcttt aatgaagact tcaagaaagc attccaaaag 1080
cttgtgcgatgtcgatgtta g 1101
<210>27
<211>6103
<212>DNA
<213>人
<400>27
atccggggca gcggggaatg gctgagccag gggttcgccg cccccgccgc cgccgccgcc 60
gccgccgccg ccgccgccgc ccgctttcgg ctcgggcctc aggaccgtag catcctgaga 120
cattttgaat tgacacttct caagatttga ctggatcaga gttcatcatg tcaaagttga 180
aaagctcaga gtcagtcagg gtggtggttc gctgtcggcc catgaatggc aaggaaaagg 240
ctgcttcgta tgacaaagtg gtggatgtgg atgttaagct ggggcaggtg tctgtgaaga 300
accccaaagg gacggcccat gaaatgccca agaccttcac ctttgatgcc gtctatgact 360
ggaatgccaa gcagtttgaa ctgtacgatg agacgttccg accacttgtt gactctgtcc 420
tgcaaggttt caatggaacc atttttgcct atggacaaac tgggacagga aaaacctaca 480
ccatggaagg aatccgtggt gaccctgaaa aaagaggagt cattcctaac tcatttgacc 540
atatcttcac ccacatctct cgatcccaga atcaacaata cctggtcagg gcttcttact 600
tagagatcta ccaggaggag atccgagatt tgctctcaaa ggatcagacc aaaaggcttg 660
agctcaaaga gaggcctgac acaggagtgt atgtgaaaga cctgtcttcc tttgtcacca 720
agagtgtgaa ggagatagag catgtgatga atgtggggaa ccagaaccgt tctgtcggtg 780
ctaccaacat gaacgagcac agctcgcgtt ctcatgcaat tttcgttatc actattgagt 840
gcagcgaggt gggcctcgat ggtgaaaacc acatccgtgt aggaaaattg aaccttgtag 900
atcttgctgg cagcgaacgg caagccaaga ccggcgcaca aggggagaga ttaaaagaag 960
ctaccaagat caacctctcc ctttccgctt tgggtaatgt catctctgct ctagtggacg 1020
gcaaaagcac tcacattcca tatcgggact caaagcttac caggctcctc caagattccc 1080
ggtggcaa tgccaagact gtgatggtgg ccaacgtggg gcctgcctct tacaacgtag 1140
aagagactct gaccactctg cgatatgcca accgtgccaa aaacattaag aacaaaccaa 1200
gggtcaatga ggaccccaag gatgccctcc ttcgagaatt ccaggaagag attgctcggc 1260
tcaaggccca gctggaaaaa cggtccattg gtaggaggaa gaggcgagag aagcggaggg 1320
aaggtggtgg cagtggtggg ggtggggaag aggaggagga ggagggagaa gagggtgagg 1380
aggaagggga tgataaggat gattactggc gggaacagca agaaaaactg gagattgaga 1440
agcgggccat tgtagaggat cacagcttgg ttgcagagga gaagatgagg ctgctgaagg 1500
agaaagagaa aaagatggag gacctgcggc gggagaagga tgctgccgag atgctgggcg 1560
ccaagatcaa ggccatggag agtaagttgc ttgttggagg aaaaaatata gtagatcata 1620
cgaatgaaca gcagaaaatc ctggagcaga aacgacagga aattgcagag cagaaacgtc 1680
gagaaagaga aatccagcaa cagatggaaa gtcgagatga ggagaccttg gaacttaaag 1740
agacatacag ctcattgcag caagaggtgg acatcaagac caaaaaactc aaaaagctct 1800
tctccaagct tcaggcagtg aaggctgaga tccatgacct ccaagaagaa cacatcaagg 1860
agcgccaaga gctagagcag actcagaatg agctcaccag ggagctgaaa ctcaagcatc 1920
ttattataga aaactttatc cctctggaag aaaaaagtaa aattatgaat agagccttct 1980
ttgatgaaga ggaagatcat tggaaactac atcctataac cagactggag aaccagcaga 2040
tgatgaagcg gccagtctca gccgtgggat ataagagacc attgagccag cacgcaagaa 2100
tgtccatgat gattcgtcca gaggcccgat atagggcaga aaacattgtg ctgttagagc 2160
tggacatgcc cagccggacc accagagact atgagggtcc agccattgcc cccaaggtcc 2220
aggctgcatt ggatgcggct ctgcaggatg aagatgagat acaggtggat gcatcatcat 2280
ttgaaagcac tgcaaataag aaatccaagg ccaggcctaa aagtggaagg aagtcgggat 2340
cctcctcctc ttcctcagga acccctgcat ctcagcttta tccacagtct cgggggctgg 2400
ttccaaagta aagccagctt ctcctctccc agggcggaaa cagcatttgc cttctgagag 2460
aagagactag caaaaagctg cagagaggat tcggcccaaa ctcagaactg ttcccctgag 2520
gagaagcggt ggcctctttg cagatcaacc aacttaatct ggttgaacgt gctgttccta 2580
atctggcact cagcccctct gggaaacatc ttttaattag catctcagaa atgcatgggt 2640
aaggtaaagt gcgatagttc aagtggaaag caagagaatg accagtgacc ttgcttcctt 2700
cccccttgcc ttcttctccc ccttcccctg tgctcccttt ctctcctctc tccttttcta 2760
ctgttctt tacatggggc tcccttcttg ttgaacaata gggcagaatc aggagtcacc 2820
ttagcaggac cacatctttg gagcctcggg ataaaatgac agtgaggttg aaaagtgaaa 2880
accctagaac ttgaataggt gcctgttctt gtagggagaa atgagaaatc gcatttggat 2940
ccaggcccca ggtgggcacc atcagcagtc ttgcttccat gcacctcagt aagaagtgga 3000
tctgcctttg ggacctgctc agtgaggaaa tctcttccaa tttctgcttc tgaatgattc 3060
aatgttggga gcaatagaaa taacattccc tttgccttct ctgagtgttt agggaaatag 3120
cttctttaaa acctcaaaac catgaccatc ctgtcaaaga cctaagtctg taagctggtg 3180
ccatgtccat acaccatgtc actttactct tcatttgtca ccatcttttc ccatgcacgc 3240
atactctgaa catccttgtg tgggcccatc ctctgcatcc agagcatgct ctgcagtggg 3300
cctgttttgt ggaagaaagg aggctgtctc tgccttctct gatgggactg gagttgaggg 3360
aaggagctgt attgtggcac ttctgaattc cccgttttgt tccatattgg tatagagagc 3420
agaagagtag ctaggcagat gcagagatgg agacatgaga ctcagtgcag tgggcaggga 3480
agacataaca gatggaagca aaggaatcct gcctgccttc agcagagaat tcaccgaatc 3540
ctagaactgt ggctccctcc aggcagagcc taagatgctg gtgaagaata gctgtgtgat 3600
tgaataggct caaaggagag ttcagaattc ccatttacat attactagtt tggtttgtaa 3660
gttttagttc cttgtattat tgagattcag agcttcattt tatgttggtc attaggtgaa 3720
tattactcat tttccctcaa gagaagctca taagtgtgtg tgggtgtgag agcacgatgg 3780
tgcctgtgtt ctgtgaatgt gtccatatgt gtctgtaaga gagacagaga ccaagaactt 3840
gcccaatttt agaaatacac taatgtgcag ttgttgcctt ttgtctgtat tgaaggccca 3900
ttgaatgact aatccaggct ggaagcattc ccatgtgggt gtctgagtcc atgagccaag 3960
cctgagggga cagtgagtct ccaggtctgc cacactggtg caccttgctg gcacggtgcc 4020
tcaggaaggt ggcgactcag gtgggccttg agttatattt taactcagct gctcagttcc 4080
cagggcacat ttctggatca gaacccatgg gaaacaggag gtactaagtg caatgtctta 4140
gcattctgca aaatggagat ctgttgtcca gcggcttatc tcctttttag taacccttct 4200
ttctgaaccc agggcccttt tcagccttcc ctcatatttt cttgagatca aactttactt 4260
ctttcttatt tactaagaat ttgcctgttt gaataagaac aaaacgctaa ggtgggtagc 4320
ctaagctgat tttctgctgg ttacacgtgt ctctcacacc acatttcctc aaagctaatc 4380
tgaattctgt aggctaaaaa tattcatgta gcaaatctga gaattgaaaa ctgcagataa 4440
ccggccgggt atggtgactc atgcctgtaa tcctagcact ttgggaggcc gaggtgggtg 4500
ccacctga ggttaggact tcaagaccag cctggccaac atggtgaaac cccatctgta 4560
ctaaaaatac aaaaatttgc ctggtgtggt ggtgcatgcc tctagtccta gctactcggg 4620
aggctgaggc acgagaatca cttgaacctg ggaggcggag gttgcagtga gtcgagataa 4680
cactactgca ttccagcctg ggtgacagag tgagactcca cctcaaaaaa aaaaaaaaaa 4740
aaaaaaaaaa cagaaagaaa gaaaaagaaa actgcagata accctataca ttaatactgg 4800
tatctcgagg tgactcttct gaccaagggt ggttaagtga cacatagaac ttttctaaga 4860
gaagacagac aagttgacag gcatgccttg tactcagctg tgttcatgtg gtggtctgtg 4920
gaaagaaaag aagactcatt tggaaatgaa gctgtccctt tccaagcagt ctctggtgct 4980
tttcttctct caaaatggat ccgataaata tttgaataga gcagattgta gaatgtcgtg 5040
tgtcaccag aaagctgctg ttttgggttc tgcattgagc caaatatgta gaggacctac 5100
caagcccact gagggactag gttttcatgt ctctagtcat acctagaatg ttctgagccg 5160
tctgagggcc ttcatgccgg cagcagctag caaagccaga aagcaagtct aacaggatct 5220
aagatgacca tcaggagaag gagtttgaga ctgtgtatgc aacccccaat agaccccctt 5280
ttactctgat ctggagaatg tatctggctt catattttca agtcacatgt ctctcagacc 5340
cctggattca gaacccaagg ccacaaatca taggcatgaa gcactttctt aagactgacc 5400
taacgctgga ttatttcccg tccaatgcct gcatgctgct tgaattgctc cacccacacc 5460
tccatgacca agggcgccag agtgctgcaa ctggggcgtg ggccgctctc tgcttttcct 5520
gtctgactct gacaagtcct ccctcactga atgtagaatc gttgccaagt ttctgagaag 5580
tgtcgattcc ctgttaacat ggatatcagt tctgcctcac atttcccact tgaggttgag 5640
gcgtactgga gacaacacct cagaccatct gaaccccatc agtggacgaa aatggggctg 5700
ttaatatact ctaaaagcca tactaaaaat gctctgaggg aactggctaa gaatagtggg 5760
cctggtgatt gtctatcacg caaggctttg ttttgtactg ttcagaaatc tgtcaccttt 5820
ctgcctgccc ttgtttcctg aatgaaatgc ttctggggtt atttatgaaa ggagtgatcc 5880
tggggcaggc aggaggcagt gggcttcatg gctccttgaa gttattactg atcttgacct 5940
tctctttggc tacctttaga caaagaatac gccaatcaat acttggggct ctaagtttta 6000
caattgatat ttatttgtat catctctttg tctaggaatg taaaagtgat tctaaactaa 6060
gatgtgtaat aaaaatcaat cagatttatt gtacctacaa aaa 6103
<210>28
<211>1318
<212>DNA
<213>人
<400>28
atgaaggcca ctatcatcct ccttctgctt gcacaagttt cctgggctgg accgtttcaa 60
cagagaggct tatttgactt tatgctagaa gatgaggctt ctgggatagg cccagaagtt 120
cctgatgacc gcgacttcga gccctcccta ggcccagtgt gccccttccg ctgtcaatgc 180
catcttcgag tggtccagtg ttctgatttg ggtctggaca aagtgccaaa ggatcttccc 240
cctgacacaa ctctgctaga cctgcaaaac aacaaaataa ccgaaatcaa agatggagac 300
tttaagaacc tgaagaacct tcacgttgtc taccttcata acaacaatat ctctgtagtt 360
ggatcaagtg acttctgccc acctggacac aacaccaaaa aggcttctta ttcgggtgtg 420
agtcttttca gcaacccggt ccagtactgg gagatacagc catccacctt cagatgtgtc 480
tacgtgcgct ctgccattca actcggaaac tataagtaat tctcaagaaa gccctcattt 540
ttataacctg gcaaaatctt gttaatgtca ttgctaaaaa ataaataaaa gctagatact 600
ggaaacctaa ctgcaatgtg gatgttttac ccacatgact tattatgcat aaagccaaat 660
ttccagttta agtaattgcc tacaataaaa agaaattttg cctgccattt tcagaatcat 720
cttttgaagc tttctgttga tgttaactga gctactagag atattcttat ttcactaaat 780
gtaaaatttg gagtaaatat atatgtcaat atttagtaaa gcttttcttt tttaatttcc 840
aggaaaaaat aaaaagagta tgagtcttct gtaattcatt gagcagttag ctcatttgag 900
ataaagtcaa atgccaaaca ctagctctgt attaatcccc atcattactg gtaaagcctc 960
atttgaatgt gtgaattcaa tacaggctat gtaaaatttt tactaatgtc attattttga 1020
aaaaataaat ttaaaaatac attcaaaatt actattgtat acaagcttaa ttgttaatat 1080
tccctaaaca caattttatg aagggagaag acattggttt gttgacaata acagtacatc 1140
ttttcaagtt ctcagctatt tcttctacct ctccctatct tacatttgag tatggtaact 1200
tatgtcatct atgttgaatg taagcttata aagcacaaag catacatttc ctgactggtc 1260
tagagaactg atgtttcaat ttacccctct gctaaataaa tattaaaact atcatgtg 1318
<210>29
<211>1313
<212>DNA
<213>人
<400>29
ggggggcgca gcaggccagg gcaacccgcc gcgaggcggc gtccacgccg aggagccgcg 60
cattcccggt ccacacagac gcggcggagc gccctcccag gcgggactac aactcaatgc 120
ctggcacggg ggcgggctcg gcggtgactt aatccgggct gagtttggtg gtggtagtga 180
gggcaggtag gggcactgcc cattttggcc aagggtcaca cagcatctac atcacaattg 240
caccggagtt taaaaatgtc tggccctgtc cctccccacc acccgccgct gtgtccagac 300
gagaatgtt ctaacgctgg gggcggctgc ggatgaagtc cttggggaga aaaggagcag 360
gccaagggcg atggtggagt agagctgcct ctcagaggca gcatgagctg agagggtgat 420
aggaaggcgg cgctagacag catggaggac tttctgctct ccaatgggta ccagctgggc 480
aagaccattg gggaagggac ctactcaaaa gtcaaagaag cattttccaa aaaacaccaa 540
agaaaagtgg caattaaagt tatagacaag atgggagggc cagaagagtt tatccagaga 600
ttcctccctc gggagctcca aatcgtccgt accctggacc acaagaacat catccaggtg 660
tatgagatgc tggagtctgc cgacgggaaa atctgcctgg tgatggagct cgctgaggga 720
ggggatgtct ttgactgcgt gctgaatggg gggccactgc ctgaaagccg ggccaaggcc 780
ctcttccgtc agatggttga ggccatccgc tactgccatg gctgtggtgt ggcccaccgg 840
gacctcaaat gtgagaacgc cttgttgcag ggcttcaacc tgaagctgac tgactttggc 900
tttgccaagg tgttgcccaa gtcacaccgg gagctgagcc agaccttctg cggcagtaca 960
gcctatgctg cccccgaggt gctgcagggc attccccacg atagcaaaaa aggtgatgtc 1020
tggagcatgg gtgtggtcct gtatgtcatg ctctgtgcca gcctaccttt tgacgacaca 1080
gacatcccca agatgctgtg gcagcagcag aagggggtgt ccttccccac tcatctgagc 1140
atctcggccg attgccagga cctgctcaag aggctcctgg aacccgatat gatcctccgg 1200
ccttcaattg aagaagttag ttggcatcca tggctagcaa gcacttgata aaagcaatgg 1260
caagtgctct ccaataaagt agggggagaa agcaaaccca aaaacccgct tct 1313
<210>30
<211>3401
<212>DNA
<213>人
<400>30
atgaggaggt cgctgagagc tgggaagagg cggcagacag cggggaaatc caaatctcct 60
cccaaagtgc ccattgtgat tcaggacgat agccttcccg cggggccccc tccacagatc 120
cgcatcctca agaggcccac cagcaacggt gtggtcagca gccccaactc caccagcagg 180
cccacccttc cagtcaagtc cctagcacag cgagaggccg agtacgccga ggcccggaag 240
cggatcctgg gcagcgccag ccccgaggag gagcaggaga aacccatcct cgacaggcca 300
accaggatct cccaacccga agacagcagg cagcccaata atgtgatcag acagcctttg 360
gtcctgatg ggtctcaagg cttcaaacag cgcagataaa tgcaggcaag aaaagatgcc 420
gccgttgctg ccgtcaccgc ctcctgggtc gtccgccacg ggttgcactg ccgtggcaga 480
cagctggact tgagcagagg gaacgacctg acttacttgc actgtgatcc cccttgctcc 540
gcccactgtg accttgaacc ccatgcactg tgacctcccc ccttctcccc cttcccactg 600
tgattggcac atcgacaagg gctgtcccaa gtcaatggaa agggaaaggg tgggggttag 660
gggaaggttg gggggaccca gcaaggactc agagagtcag acagtgccac ttggccactt 720
ggggtaaagc cagtgccagc aataacagtt tatcatgctc attaatttgg gatttcaaaa 780
cacaaatgaa aactcacacc cacccacccc caagtgcatg tctccatcac ttaaaaagta 840
agttccattt gaaaatatcc tttctttttt ttttcttcct atttttgttt gtttatacaa 900
atatctgatt tgcaagaaaa agtgcatggg aggggtttta gtggtttaat gaatttttaa 960
ttaagaaagg gtagtttggt agtctactta aaaatgtttc tgggaaattc actagaaaca 1020
ttaaccaata ggattttggt gagcttagct tctgtattcc tactgccgcc cagaaaaggg 1080
gcagggctct gcagccgcca ggacagacga gcaccccatg cctatacctc cctccccgag 1140
ctaagtccca gggcatctgg gccttgcctg gagactgggc tagctctgta ggctcggaga 1200
gcctggggag ggtgccaacc ccacctctag tattttggga gatagggaaa gtgaaccgac 1260
ttccccttcc catacccctc agggtggttc cctaccagcc aggcttacta cttctagaag 1320
aaagcagagt gccagggagt gagattgcat ccctgggctt agaagtgacg gagagaagac 1380
ttgtttagta ttttgccatc agcacaagga aaaccaggag agagtctgcc tccaggactc 1440
tgagccttct gcctcatatg ttcagaaggt ggataggtct tcccactcca gcatggcttg 1500
ctcttagg ggtctgcagt gctccatctc cattggtggc cccagctcag taactatacc 1560
tggtacattt cctgtgtgca atcagtacct tgaaggcaga acattctgaa taaagttgga 1620
aaaagaacag ctttgctttg caaagattga tgacagactg gttcctcaga ggcctaggct 1680
acccgtcacc cctttttcca gagcgagggc ctggaatgaa ggcagtttat cctctgtccc 1740
tggagcctgg ggtttgcttt ggctccttga ggtggaagag actaagaggg cagctgccca 1800
gagcagctgt gtgtacctgg ctcctctcag gcttcctgat cccttccgtt gcactgcgcc 1860
ttatccctca gccagccaga cagcctccct gctcctgacc agcagatacg tttcggagtg 1920
gttggtgtgg tttttgtgat gagggcagca cgtggtggcc aaggtggcaa gctgagtctc 1980
acaggctcac tccctcgttg gttccctgtg ggaatggtag gccaggccca gtaagccatg 2040
cccaacacg tcctctcctc cggaggaagg gccagctgcc agctgagtca gcagctagtc 2100
catagcacag ccttataact gtaaagccag gcattgccca tgagcagagc tggaaccaga 2160
gcttcagtca gtaagaggga ggattacctt caggagaagg caaggaagaa aactggctgc 2220
tatctttata gttccactgc cctaaccaag tgtccacatt ctaaatgtgt agtgtccatc 2280
ccttatgtaa tagtggtttc ccgcccaaag tgagactttc cttttaattg gagaagggta 2340
tagaggtagt ccaggtggga acgccagaag tgctgattgc ccagccattg ggaccacctg 2400
ttcttgcccc actaccctct agtgggaggc caaagtaaag gctggctggt gggtgtctgt 2460
ggattgagga tgtggcaggg actggtcctc ccacctccct ctggccaaag atgggctttg 2520
cccgctgtgt gcctgtcacc acccaccagc agtcatgccc tgggcttccc aaatggagag 2580
gtagcaggca acgtttttaa aaagaaagaa aacaggaaac tgtattgtgt cgggggaggc 2640
gggagggaga tgaggaaacg gtttggattt tgtgtgtggg agggtatttt ttgggggtag 2700
ttgtctgtaa ctttcctaag tgcttttttt ccttttcttt tttaaagtaa gttgcaggct 2760
ttggcttgga aaaccccagg gggatggggg gcagaaacct gaggctgctg cccctttatc 2820
tgccttcacg gtactgtccc cttcccccag ctcctccctg accccatggg ccaggcctca 2880
gaccttccag ctaaccgctt cccatgagcc actactctga tgtcagccta taaccaaagg 2940
agctgggggg tccaggcctg gtgaccaacc tttctcagcc cactcaatca gggtgctccc 3000
cacctgcagg caggaggcaa caccctatct gctaccatca gccccttcca gagcccatct 3060
gccccgccca gccctgccct gcccagccat accctgctct gccccatctg ggggtgccct 3120
gctcagggat gggctggcag ggctgtaccc agcctccctg gtaagcagag actcaagaaa 3180
tctggggt cctgttttct ggtcgtgtga tcccaggggt gcacatgggc cccttgggtg 3240
tctgaacaga agggcatggg agggagggct gcacccctgc agtcttactc tgctggtgta 3300
gcgggcagct gcccactccc accccaccct gcaccgcggg ctcctgagtc ggcagattaa 3360
gcattttata aattgtattt taaatacatg ttttaaactt g 3401
<210>31
<211>5470
<212>DNA
<213>人
<400>31
gattgccccc tgtgggtcac tttctcagtc attttgagct cagcctaatc aaagactgag 60
gttatgaagt cgatcctaga tggccttgca gataccacct tccgcaccat caccactgac 120
ctcctgtacg tgggctcaaa tgacattcag tacgaagaca tcaaaggtga catggcatcc 180
aaattagggt acttcccaca gaaattccct ttaacttcct ttaggggaag tcccttccaa 240
gagaagatga ctgcgggaga caacccccag ctagtcccag cagaccaggt gaacattaca 300
gaattttaca acaagtctct ctcgtccttc aaggagaatg aggagaacat ccagtgtggg 360
gagaacttca tggacataga gtgtttcatg gtcctgaacc ccagccagca gctggccatt 420
gcagtcctgt ccctcacgct gggcaccttc acggtcctgg agaacctcct ggtgctgtgc 480
gtcatcctcc actcccgcag cctccgctgc aggccttcct accacttcat cggcagcctg 540
gcggtggcag acctcctggg gagtgtcatt tttgtctaca gcttcattga cttccacgtg 600
ttccaccgca aagatagccg caacgtgttt ctgttcaaac tgggtggggt cacggcctcc 660
ttcactgcct ccgtgggcag cctgttcctc acagccatcg acaggtacat atccattcac 720
aggcccctgg cctataagag gattgtcacc aggcccaagg ccgtggtggc gttttgcctg 780
atgtggacca tagccattgt gatcgccgtg ctgcctctcc tgggctggaa ctgcgagaaa 840
ctgcaatctg tttgctcaga cattttccca cacattgatg aaacctacct gatgttctgg 900
atcggggtca ccagcgtact gcttctgttc atcgtgtatg cgtacatgta tattctctgg 960
aaggctcaca gccacgccgt ccgcatgatt cagcgtggca cccagaagag catcatcatc 1020
cacacgtctg aggatgggaa ggtacaggtg acccggccag accaagcccg catggacatt 1080
aggttagcca agaccctggt cctgatcctg gtggtgttga tcatctgctg gggccctctg 1140
tgcaatca tggtgtatga tgtctttggg aagatgaaca agctcattaa gacggtgttt 1200
gcattctgca gtatgctctg cctgctgaac tccaccgtga accccatcat ctatgctctg 1260
aggagtaagg acctgcgaca cgctttccgg agcatgtttc cctcttgtga aggcactgcg 1320
cagcctctgg ataacagcat gggggactcg gactgcctgc acaaacacgc aaacaatgca 1380
gccagtgttc acagggccgc agaaagctgc atcaagagca cggtcaagat tgccaaggta 1440
accatgtctg tgtccacaga cacgtctgcc gaggctctgt gagcctgatg cctccctggc 1500
agcacaggaa aagaattttt ttttttaagc tcaaaatcta gaagagtcta ttgtctcctt 1560
ggttatattt ttttaacttt accatgctca atgaaaaggt gattgtcacc atgatcactt 1620
atcagtttgc taatgtttcc atagtttagg tactcaaact ccattctcca ggggtttaca 1680
gtgaagaaag cctgttgttt aagtgactga acgatccttc aaagtctcaa tgaaatagga 1740
gggaaacctt tggctacaca attggaagtc taagaaccca tggaaaaatg ccatcaaatg 1800
aataatgcct ttgtaaccac aactttcact ataatgtgaa atgtaactgt ccgtagtatc 1860
agagatgtcc atttttacaa gttatagtac tagagatatt ttgtaaaatg tattatgtcc 1920
tgtgagatgt gtatcagtgt ttatgtgcta ttaatatttg tttagttcag caaaactgaa 1980
aggtagactt ttatgagaac aatggacaag cagtggatac gtgtcaatgt gtgcactttt 2040
tttctatatt attgcccatg atataacttt agaaataaac cttaatattt cttcaaatat 2100
ctctatttaa ttttgacact gaaataaccg taaaggttta tttttctgtt acctcaacaa 2160
gaagaatttg aagacttcaa aatattgagc agaattcatt catacttaaa aatttattag 2220
ccctgcattt tcataggaag acacattatc ttctggacta tagctgttct aatggattat 2280
aatcagaatg gaagagagaa agcatattga ctttttttga gcgacatctc tgactttctt 2340
tagtctttag ctattactgg atctcttaag acagcatgtg ttaatcttaa tgtatatcgt 2400
tatcactgtg cagttgctgt ttacttgaat agtattgtgt tcctatattc caggtttaag 2460
tagatttcat gcctgggtgg ccaaacaaca gtcttcattt tttttaattg aaaagaagta 2520
gtgtctggat cagtaaaatt atactgtgtg tgagtgtgaa tataaatgtg tgtatgtgtg 2580
tttctgtcct gtaactgtta cagtaatgtc ataaagtgag aaaactgtga ccaagtataa 2640
acttttacca cttgctgcac tcttgcacat ggattcagtt tctaaaattg agttcttcct 2700
gtaatcttgt tgataaaaat actgactcca accattcaaa aatttcaccc catccctcct 2760
taagagattg gatcaagtat tactaaattg acctttaggt attacacaag accagtgctt 2820
caaaaaat aatgacaggc atccaaggaa gggatgtatt tgtagtgtta ttgccaggaa 2880
aggagagtac tttggtttct gagcaccgaa tattgagcaa tatgtcagtc actaaaagga 2940
agacagttct acagaaaaac aatggtaaca tttttcaata gcgtgtgtag atagtatgca 3000
ctatatacat cacgttaaag taggactatc acacccagcc catgtggcta aaaaagctga 3060
atcagacagt ggatgagaca cacaacggca gtgaagaacc gatacacttg gcattgacgt 3120
ctagctatgc tgtatctgtg ctttgcccac atgcccttgg tgacagctga gcacccagct 3180
ctgtcttggt aggtttgggc taaggaacaa atctctcctt tgctcgtggt tagcaagata 3240
cactcaagca tgaagataaa cacagctgct ttcttcttac accccggtct catgctcctt 3300
aatggcgcca tgggtgcttg ttgggccttt ttccagtaag gaatgatatt gctgaagaat 3360
ctacttaacc ctgacaaatt ttaattataa tctcttctta tacagataaa acatgactcc 3420
acaaggccc caaggtttac atagtctgaa gtgaagtaca gagctggcat ctatctggtg 3480
atttctagct ctcgagatac ccaagcagcc tgatggggca gttccccttc ttacggttca 3540
cgctctaagg caggatgtgg cttatgagat actttgcatt gtctgtctgc acaccttgaa 3600
tctgcctgct ggctccctta ctttacctct ctgtcatgtg cagatgaagg ctcagggtgc 3660
tagaggatta gtaagatctc tttctaaaga caggagagat tatttacaag aagaactcac 3720
cagggtttag tttgcattta agaattgcca gtcttttgtc ctgcatcatc ttgaacatta 3780
atccacatgt ttcagagctc accaggcagt accaatgctc ttttcacagc tatgaagagc 3840
tagagaaatt cttgttatgg tagaaaaatt tcacgattca tttttgaaac tgcatttgtg 3900
cgtatgcagt gtagatttta tagtgtgttg tgctttcaag atctaaatca tatataataa 3960
attaagggac aatggggctg acagcactaa acttggtgct tattgatatt ctaagaaata 4020
tctgtgaaat atcatcacgt atgttataca accttcattt aaaaaggttt aaaactagtt 4080
agattcactt tgacactttt catatcattt cttaacccaa gtgacgaaaa cattgtcccc 4140
aatgaatata ctcattagaa ttaccatttg ttaatatcac tcattaatta accccataat 4200
tagatccatt aatttaaatg atttaaattt aagtaagttt tataaggtct gacatcagag 4260
gtatcttact ttcctctgag gatgatgtac ttgccctgac catgcatttt accatcacac 4320
atgttcagaa agggccaaat tcccaacctg ctcatttttt ttttatcaga gtcatgatga 4380
atcagtccta gaatgtttca tttgcacaag tagggctgcc tccaagagga acctctgatt 4440
tattttgtat gaaatatatg tgaaaggata tgaatctgag agatgctgta gacatctgtc 4500
ctacacttga gatgatttcc aagcctctct ggcactttga gttaagtcta tctggtatta 4560
tgccaagg accttttgct gcctaaatcc actctgcagg aaataggccc aaccaccaga 4620
tgagaattag gccctggatg agtagcgcta tagttactgt cctgttgatt aatttctgcc 4680
atttcatgtc cataaaagag accacccata tcatgcacac aattagattt ctcacactct 4740
aactgtatat ttgtatgata ttttaaaatc tcctaaatgc tgggcaatgg ctattaacaa 4800
ttaattgtct tgcactggcc ttctgatgaa atgttaacaa tgcctattgt aatatagaaa 4860
aaaacattct atctactgat ttgggctgaa tgtatgtaaa taggtttcta aaaagtcaga 4920
tgtttgagca gtggcctaca aatcagtaat tttcggatgg gagagtttct ttacattgcc 4980
gtggcatctt aaaagctatc ttcatgtaaa ttgactgtac taggcctact ggggatcaga 5040
gttcccaaga aaggaaacct tttcttgtat ctggattcaa atttatttcc aatgtttcaa 5100
cgggaaaca tgactcttta ttgtctgtaa atctaacatt attacttttc ctcttagaag 5160
aatattgtat tgttagatgt ttgttgagct ggtaacatcg ttgcaaccac tgcaatatct 5220
tcgttagtaa tctgtataat actttgtata caagtactgg taagattgtt attaaatgta 5280
gcttcagtca ttaaattact atagcaaagt agtacttctt ctgtaatatt tacaatgtat 5340
taagcccaca gtatatttta tttcaatgta attaaactgt taacttattc aaagagaaaa 5400
catctcatca tgtctattgt ccaaagttac ctggaatcaa ataaaaattc tagattacca 5460
tgaagaacat 5470
<210>32
<211>1517
<212>DNA
<213>人
<400>32
gcggcgcgga gggcgcgggc ccgggagcca gggagcgagc ggggcgcccg gcagcgcgga 60
gtcagcgccg cgggggccgc acccgactcg cgcctggaca ctcgcggggc gccgacctgg 120
cagggggcca aaccagtgct cctgccacct ctctggctgc cccctagagc ctgcccatcc 180
cagcctgacc aatgtccaca gccagggagc agccaatctt cagcacacgg gcgcacgtgt 240
tccaaattga cccagccacc aagcgaaact ggatcccagc gggcaagcac gcactcactg 300
tctcctattt ctacgatgcc acccgcaatg tgtaccgcat catcagcatc ggaggcgcca 360
gccatcat caacagcact gtcactccca acatgacctt caccaaaact tcccagaagt 420
tcgggcagtg ggccgacagt cgcgccaaca cagtctacgg cttgggcttt gcctctgaac 480
agcatctgac acagtttgcc gagaagttcc aggaagtgaa ggaagcagcc aggctggcca 540
gggagaaatc tcaggatggc ggggagctca ccagtccagc cctggggctc gcctcccacc 600
aggtgccccc gagccctctc gtcagtgcca acggccccgg cgaggaaaaa ctgttccgca 660
gccagagcgc tgatgccccc ggccccacag agcgcgagcg gctaaagaag atgttgtctg 720
agggctccgt gggcgaggta cagtgggagg ccgagttttt cgcactgcag gacagcaaca 780
acaagctggc aggcgccctg cgagaggcca acgccgccgc agcccagtgg aggcagcagc 840
tggaggctca gcgtgcagag gccgagcggc tgcggcagcg ggtggctgag ctggaggctc 900
aggcagcttc agaggtgacc cccaccggtg agaaggaggg gctgggccag ggccagtcgc 960
ggaacagct ggaagctctg gtgcaaacca aggaccagga gattcagacc ctgaagagtc 1020
agactggggg gccccgcgag gccctggagg ctgccgagcg tgaggagact cagcagaagg 1080
tgcaggacct ggagacccgc aatgcggagt tggagcacca gctgcgggcg atggagcgca 1140
gcctggagga ggcacgggca gagcgggagc gggcgcgggc tgaggtgggc cgggcagcgc 1200
agctgctgga cgtcaggctg tttgagctga gtgagctgcg tgagggcctg gcccgcctgg 1260
ctgaggctgc gccctgagcc ggggctggtt ttctatgaac gattccggcc tgggatgcgg 1320
gccaggctgc aggcggcata gttgggccca ttcgtcctgg aaagggactg gggggtccca 1380
acttagccct gggtgggccg ggccgggctg ggctggggtg ggccccagtc ggctctggtt 1440
gttggcagct ttggggctgt ttttgagctt ctcattgtgt agaatttcta gatcccccga 1500
ttacatttct aagcgtg 1517
<210>33
<211>1228
<212>DNA
<213>人
<400>33
agagatgggg acggaggcca cagagcaggt ttcctggggc cattactctg gggatgaaga 60
ggacgcatac tcggctgagc cactgccgga gctttgctac aaggccgatg tccaggcctt 120
cagccgggcc ttccaaccca gtgtctccct gaccgtggct gcgctgggtc tggccggcaa 180
gcctggtc ctggccaccc acctggcagc ccgacgcgca gcgcgctcgc ccacctctgc 240
ccacctgctc cagctggccc tggccgacct cttgctggcc ctgactctgc ccttcgcggc 300
agcaggggct cttcagggct ggagtctggg aagtgccacc tgccgcacca tctctggcct 360
ctactcggcc tccttccacg ccggcttcct cttcctggcc tgtatcagcg ccgaccgcta 420
cgtggccatc gcgcgagcgc tcccagccgg gccgcggccc tccactcccg gccgcgcaca 480
cttggtctcc gtcatcgtgt ggctgctgtc actgctcctg gcgctgcctg cgctgctctt 540
cagccaggat gggcagcggg aaggccaacg acgctgtcgc ctcatcttcc ccgagggcct 600
cacgcagacg gtgaaggggg cgagcgccgt ggcgcaggtg gccctgggct tcgcgctgcc 660
gctgggcgtc atggtagcct gctacgcgct tctgggccgc acgctgctgg ccgccagggg 720
gcccgagcgc cggcgtgcgc tgcgcgtcgt ggtggctctg gtggcggcct tcgtggtgct 780
gcagctgccc tacagcctcg ccctgctgct ggatactgcc gatctactgg ctgcgcgcga 840
gcggagctgc cctgccagca aacgcaagga tgtcgcactg ctggtgacca gcggcttggc 900
cctcgcccgc tgtggcctca atcccgttct ctacgccttc ctgggcctgc gcttccgcca 960
ggacctgcgg aggctgctac ggggtgggag ctcgccctca gggcctcaac cccgccgcgg 1020
ctgcccccgc cggccccgcc tttcttcctg ctcagctccc acggagaccc acagtctctc 1080
ctgggacaac tagggctgcg aatctagagg agggggcagg ctgagggtcg tgggaaaggg 1140
gagtaggtgg gggaacactg agaaagaggc agggacctaa agggactacc tctgtgcctt 1200
gccacattaa attgataaca tggaaatg 1228
<210>34
<211>2057
<212>DNA
<213>人
<400>34
aaaaaaaaaa acacaggctt gatgctcgct cccgtttcta caggaggttt tgacggctgg 60
atgctgcagg gcatcccctc gcctggagga ggttcacttg tggccaggtt cccagcacac 120
ccacttgctc actggggccc tggggacacc gccacactcg agcccatcct acggcctcaa 180
tccttaccag tccccaggcc atggactgcc acactgtagg tcttcaatca aggtttagtg 240
gtttcgaa tgtacacaca ccctgaaaga cagcgaggcc acctcagaaa acaacgcgcg 300
cccagctggc tcccctccga cagggcccac ggctactggg tcggcctcct ccggaccctg 360
agcacagcct ggtatgcgtg cgggctcgga atacggatct gagcagaaga aatgcgagtg 420
gagagcggtt ctgcgcagga aagaggaatt ttgttggaaa gcctgtcgac gttgctagaa 480
aagaccacag catctcacga ggggcgtgcg ccgggaaacc gggagttgac ggacctcctg 540
ccccccgagg tctgcagtct cctgaaccca gcagccatct acgccaacaa cgagatcagc 600
ctgcgtgacg ttgaggtcta cggctttgac tacgactaca ccctggccca gtatgcagac 660
gcactgcacc ccgagatctt cagtaccgcc cgtgacatcc tgatcgagca ctacaagtac 720
ccagaaggga ttcggaagta tgactacaac cccagctttg ccatccgtgg cctccactat 780
gacattcaga agagccttct gatgaagatt gacgccttcc actacgtgca gctggggaca 840
gcctacaggg gcctccagcc tgtgccagac gaggaggtga ttgagctgta tgggggtacc 900
cagcacatcc cactatacca gatgagtggc ttctatggca agggtccctc cattaagcag 960
ttcatggaca tcttctcgct accggagatg gctctgctgt cctgtgtggt ggactacttt 1020
ctgggccaca gcctggagtt tgaccaagca catctctaca aggacgtgac ggacgccatc 1080
cgagacgtgc atgtgaaggg cctcatgtac cagtggatcg agcaggacat ggagaagtac 1140
atcctgagag gggatgagac gtttgctgtc ctgagccgcc tggtggccca tgggaaacag 1200
ctgttcctca tcaccaacag tcctttcagc ttcgtagaca aggggatgcg gcacatggtg 1260
ggtcccgatt ggcgccagct cttcgatgtg gtcattgtcc aggcagacaa gcccagcttc 1320
ttcactgacc ggcgcaagcc tttcagaaaa ctcgatgaga agggctcact tcagtgggac 1380
cggatcaccc gcttggaaaa gggcaagatc tatcggcagg gaaacctgtt tgacttctta 1440
cgcttgacgg aatggcgtgg cccccgcgtg ctctacttcg gggaccacct ctatagtgat 1500
ctggcggatc tcatgctgcg gcacggctgg cgcacaggcg ccatcatccc cgagctggag 1560
cgtgagatcc gcatcatcaa cacggagcag tacatgcact cgctgacgtg gcagcaggcg 1620
ctcacggggc tgctggagcg catgcagacc tatcaggacg cggagtcgag gcaggtgctg 1680
gctgcctgga tgaaagagcg gcaggagctg aggtgcatca ccaaggccct gttcaatgcg 1740
cagttcggca gcatcttccg caccttccac aaccccacct acttctcaag gcgcctcgtg 1800
cgcttctctg acctctacat ggcctccctc agctgcctgc tcaactaccg cgtggacttc 1860
accttctacc cacgccgtac gccgctgcag cacgaggcac ccctctggat ggaccagctc 1920
tgcaccggct gcatgaagac ccccttcctt ggtgacatgg cccacatccg ctgagggcac 1980
ttattgtc tgggacaggc cctcagcccc tcctgcccca tccacccaga caagcaataa 2040
aagtggtctc ctccctg 2057
<210>35
<211>2413
<212>DNA
<213>人
<400>35
attcatttcc cccagtgacc ttgacaagtc agaagcttga aagcagggaa atccggatgt 60
tcggttatg aagtggagca gtgagtgtga gcctcaacat agttccagaa ctctccatcc 120
ggactagtta ttgagcatct gcctctcata tcaccagtgg ccatctgagg tgtttccctg 180
gctctgaagg ggtaggcacg atggccaggt gcttcagcct ggtgttgctt ctcacttcca 240
tctggaccac gaggctcctg gtccaaggct ctttgcgtgc agaagagctt tccatccagg 300
tgtcatgcag aattatgggg atcacccttg tgagcaaaaa ggcgaaccag cagctgaatt 360
tcacagaagc taaggaggcc tgtaggctgc tgggactaag tttggccggc aaggaccaag 420
ttgaaacagc cttgaaagct agctttgaaa cttgcagcta tggctgggtt ggagatggat 480
tcgtggtcat ctctaggatt agcccaaacc ccaagtgtgg gaaaaatggg gtgggtgtcc 540
tgatttggaa ggttccagtg agccgacagt ttgcagccta ttgttacaac tcatctgata 600
cttggactaa ctcgtgcatt ccagaaatta tcaccaccaa agatcccata ttcaacactc 660
aaactgcaac acaaacaaca gaatttattg tcagtgacag tacctactcg gtggcatccc 720
cttactctac aatacctgcc cctactacta ctcctcctgc tccagcttcc acttctattc 780
cacggagaaa aaaattgatt tgtgtcacag aagtttttat ggaaactagc accatgtcta 840
cagaaactga accatttgtt gaaaataaag cagcattcaa gaatgaagct gctgggtttg 900
gaggtgtccc cacggctctg ctagtgcttg ctctcctctt ctttggtgct gcagctggtc 960
ttggattttg ctatgtcaaa aggtatgtga aggccttccc ttttacaaac aagaatcagc 1020
agaaggaaat gatcgaaacc aaagtagtaa aggaggagaa ggccaatgat agcaacccta 1080
atgaggaatc aaagaaaact gataaaaacc cagaagagtc caagagtcca agcaaaacta 1140
ccgtgcgatg cctggaagct gaagtttaga tgagacagaa atgaggagac acacctgagg 1200
ggtttctt tcatgctcct taccctgccc cagctgggga aatcaaaagg gccaaagaac 1260
caaagaagaa agtccaccct tggttcctaa ctggaatcag ctcaggactg ccattggact 1320
atggagtgca ccaaagagaa tgcccttctc cttattgtaa ccctgtctgg atcctatcct 1380
cctacctcca aagcttccca cggcctttct agcctggcta tgtcctaata atatcccact 1440
gggagaaagg agttttgcaa agtgcaagga cctaaaacat ctcatcagta tccagtggta 1500
aaaaggcctc ctggctgtct gaggctaggt gggttgaaag ccaaggagtc actgagacca 1560
aggctttctc tactgattcc gcagctcaga ccctttcttc agctctgaaa gagaaacacg 1620
tatcccacct gacatgtcct tctgagcccg gtaagagcaa aagaatggca gaaaagttta 1680
gcccctgaaa gccatggaga ttctcataac ttgagaccta atctctgtaa agctaaaata 1740
aagaaataga acaaggctga ggatacgaca gtacactgtc agcagggact gtaaacacag 1800
cagggtcaa agtgttttct ctgaacacat tgagttggaa tcactgttta gaacacacac 1860
acttactttttctggtctct accactgctg atattttctc taggaaatat acttttacaa 1920
gtaacaaaaa taaaaactct tataaatttc tatttttatc tgagttacag aaatgattac 1980
taaggaagat tactcagtaa tttgtttaaa aagtaataaa attcaacaaa catttgctga 2040
atagctacta tatgtcaagt gctgtgcaag gtattacact ctgtaattga atattattcc 2100
tcaaaaaatt gcacatagta gaacgctatc tgggaagcta tttttttcag ttttgatatt 2160
tctagcttat ctacttccaa actaattttt atttttgctg agactaatct tattcatttt 2220
ctctaatatg gcaaccatta taaccttaat ttattattaa catacctaag aagtacattg 2280
ttacctctat ataccaaagc acattttaaa agtgccatta acaaatgtat cactagccct 2340
cctttttcca acaagaaggg actgagagat gcagaaatat ttgtgacaaa aaattaaagc 2400
atttagaaaa ctt 2413
<210>36
<211>4977
<212>DNA
<213>人
<400>36
gggaggggcg ggatttcctg cgggaggcgc cgagccggcc ttggaaaagg agaaggagaa 60
aggggggcag gggggagtgg gagccaccgt cctgagtgcc agggaccgag cagggccagc 120
gaccccgg cgggcggccg ggagagagcc ctgagaccag tgcaccgctg ctgcctgagg 180
cccaagggaa tgctggctgc tctctgggtg ggcactggtg ttccacagcc aagccgggaa 240
gattggtgtg cccagtccca gcccatcctg gagctgtcgg aagccacaag ctgatatcca 300
tccagatttc catgtagcct tcaccccctc aaagattagc tttccttcgt gtggtggcag 360
ttcacggagc acctttggga gtatccctca gtacctgacg aggagcccac tgcctgggac 420
accagacttg ctcccccgga accgggagcc ctccaagggg ctgtggcatg gcgccctgac 480
gccccagctt ggacccgttg cctgcctttg ccctggactc ctgagtgtag agctcagccc 540
aggagccagt atgggtcgtg aacaggacct gatcctcgcc gtcaagaatg gagatgtgac 600
cggtgtgcag aaactggtgg cgaaggtcaa ggccacaaag acaaagctcc tgggctccac 660
aaagaggctc aacgtgaact accaggatgc tgatggattc tctgccctcc accacgctgc 720
tttggggggc agcctggagc tcatagcctt gctgctagag gctcaggcca ctgttgacat 780
caaggacagc aatggcatgc gcccgctgca ctacgcagcc tggcagggcc ggctggagcc 840
tgtgaggctg ctgctgcgcg cctctgcggc tgtcaatgcc gcctcgctgg acggacagat 900
ccccctgcac ctggctgcac agtatggaca ttatgaggtg tcagaaatgc tcctccagca 960
tcagtccaac ccatgcctgg tcaacaaggc caagaagacg cccctggacc tggcctgtga 1020
atttggccga ctcaaggtgg cccagctgct tctgaacagc cacttatgtg tggcactgct 1080
ggagggtgag gccaaagacc cgtgtgaccc caactacacc acgcccctgc acttggctgc 1140
caagaatggc cacagagaag tcatcaggca gctcctgaga gctgggatcg agatcaaccg 1200
ccagaccaag acgggtacgg cgctccacga ggccgcactg tatggcaaga ccgaggtggt 1260
gcggctgctt ctggagggag gtgtggacgt gaacatccgg aatacgtata accagacggc 1320
gctggacata gtgaatcagt tcaccacctc ccaggccagc cgggaaatca agcagctact 1380
gcgggaggcc tcagggatcc tgaaggtccg agcgctcaag gatttctgga acctccacga 1440
tcccactgct ctcaatgtcc gggcagggga tgtcatcacg gtgctagaac agcatcccga 1500
cggccgctgg aagggccaca tccacgagag ccagaggggc acagaccgca taggctactt 1560
ccccccgggc attgtcgagg tggtcagcaa gcgggtgggc atccctgcag cccgcctccc 1620
ctccgcaccc acccccctgc gcccaggctt ctcccggaca ccgcagcctc ctgccgaaga 1680
acccccgcac cctcttacct acagccagct tcctcgggtg ggcctcagcc cagacagccc 1740
agcaggtgac aggaatagtg tgggcagtga gggcagcgtg ggcagcatcc gcagtgccgg 1800
agcgggcag agctctgagg gcactaatgg ccatggccct ggcctcctga ttgagaacgc 1860
ccagccactg ccctctgctg gagaggacca ggtgctgcca ggactccacc cgccgtccct 1920
ggcagacaac ctgagccacc gccctctggc caactgccgc tctggggagc agatcttcac 1980
ccaggacgtg cggccagaac agctgctgga ggggaaggac gcgcaggcca ttcataactg 2040
gctaagcgag ttccagctgg agggctacac tgcccacttt ctgcaggccg gctatgatgt 2100
gcctaccatc agccgcatga cacctgagga cctgacggcc atcggggtga ccaagcctgg 2160
gcacaggaag aagatcgcct cagagatcgc tcagctcagc atcgccgagt ggctgcccag 2220
ctacatccca acggacctgc tggagtggct gtgtgcactg gggctgccac agtaccacaa 2280
gcagctggtg agcagcggct acgactccat ggggctggtg gccgacctca cctgggagga 2340
gctgcaggag attggggtca acaagctcgg gcatcagaag aagctcatgc tgggggtgaa 2400
gcggctggcg gagcttcggc ggggcctgct gcagggggag gccctcagcg aaggcgggcg 2460
ccggctggcc aagggtccgg agctgatggc catcgaggga ctggagaacg gagaaggccc 2520
agctacagct ggcccacggc tcctcacctt ccagggcagc gaactaagcc cagagctaca 2580
ggcggccatg gcagggggtg gccctgaacc actccccctc ccacctgccc gctctcccag 2640
ccaggagagc atcggggcac gctcacgggg gtctggccac tcacaggaac agcctgcccc 2700
acagcccagc ggtggagatc ccagcccccc ccaggagagg aacctcccag agggcacaga 2760
gcggccccct aagctttgtt cttcacttcc tggccaagga cccccaccct atgtttttat 2820
gtacccccag ggctcaccct ctagcccggc cccagggcca cctcctggcg caccctgggc 2880
cttctcctac ttggccgggc cccctgccac tcccccagac ccgcctcgac ctaagcgccg 2940
gtcccacagc ctaagccgcc ctggccccac agagggggat gctgaggggg aggccgaagg 3000
gccagtgggc agcaccctag gcagttatgc tacccttacc cggcggccag gacgcagtgc 3060
ccttgtccgg accagtccta gcgtgacccc aaccccagct cgggggactc ctcgcagcca 3120
gtcctttgcc ctgcgggccc ggcgcaaagg ccccccgccc ccgcccccca agcgcctcag 3180
ctccgtctct ggccccagcc cggagccacc tccactagat gggagcccag ggcccaagga 3240
aggggccaca gggccccgaa ggcgaacact gagtgaacct gctggcccct cagagccccc 3300
tggcccacct gccccggctg ggcccgcgtc agacacggag gaggaggagc caggccctga 3360
ggggacgccc ccatctcggg gcagctctgg ggaagggctg ccgtttgcag aggaagggaa 3420
cctgaccatc aaacagcgcc cgaagcccgc tggccccccg ccccgagaga cacccgtgcc 3480
ccccggcctc gatttcaacc tcacggaatc agacactgtt aagcggaggc ccaagtgccg 3540
ggagagagag ccactgcaga ccgcactgct ggccttcgga gtggccagtg ccacgcctgg 3600
ccccgctgcc ccactgcctt ccccaactcc tggcgagtct cctccagctt ctagccttcc 3660
ccagcccgag cccagcagcc ttccagccca aggagttcca accccccttg ctcccagccc 3720
cgccatgcag cctccagtgc cgccctgccc agggccaggt ctggaaagct cagcagctag 3780
tcggtggaat ggggagacag aacccccggc cgcccctgct gccctcctca aggtgcccgg 3840
agcaggaaca gcccccaagc ctgtgtcggt ggcctgcacc cagctggcat tttctggccc 3900
taagctagcg ccccggctcg gcccccgccc agtgcctcct ccacggcctg agagcactgg 3960
gactgtgggc ccaggccagg cccagcagag actggagcag accagctcgt ccctggcagc 4020
tgcactgaga gccgcagaga agagcattgg caccaaggag caagagggca cccccagcgc 4080
ctccaccaag cacattctgg atgacatcag caccatgttc gacgccctgg ctgaccagct 4140
ggacgccatg ctggactgag ccctccagca gtgcccactg tgacctgccg aagtccactg 4200
cctttgcccc agcacagaag aggcccctgc caccctaggg acgggccaag ggctggtcag 4260
gctgaagtgc ccctcctagc agggcccctt cccactcagc ccgcggctgt gggcaccaca 4320
gctcttgtgg ggcagcccac cttagaacct gactagcgag ggacctccgc tgcatctcag 4380
caaagcccct cccagggttt gatcgattga gcaggacagc cctgctcctg gacagggacc 4440
ctggtaagag ctctctcctc agggaggaag taggggtggg gctttggggg tgctttctct 4500
gtacccccca gcccatgtcc caagttgtgc caagggaatg cctcttgcca cccaccatcc 4560
tgcccaggcc ctgagaggct ggaggaggcg tgtgtctggc cgggccccct ctccgtaggt 4620
gtacagagga catgtaaata cacagcggtg gtgcccaggc agctcctgcc cccgccttcc 4680
ctcactgagg cagggctagc aggggtggga ggcagtgggg ttaacagatc ccacaagtcc 4740
taacttttca attgtaaatg ttattttcta agcagagaga aatgcatata ttttaaatgg 4800
aatttattct atcaactgcc tgagaggaca caatggggga ggggcttcgg accacagcag 4860
gagccccgac tgcccacctg agggcaggga gagcctgacc ccattggccc aggccctggc 4920
tctgtaacca ttaacctctt cccccaacta acaccaatga aaacaccatt ccacgtg 4977
<210>37
<211>6202
<212>DNA
<213>人
<400>37
cgcagactgt gctggagctg gtgctgaaaa agggggtttg cagaggctgc cctggggctg 60
gtgctgaaag aagagcccac agctgacttc atggtgctac aataacctca gaatctactt 120
ttcactctca ggagaaccca cagtctaata tttagacatg atggcaaact gggcggaagc 180
aagacctctc ctcattctta ttgttttatt agggcaattt gtctcaataa aagcccagga 240
agaagacgag gatgaaggat atggtgaaga aatagcctgc actcagaatg gccagatgta 300
cttaaacagg gacatttgga aacctgcccc ttgtcagatc tgtgtctgtg acaatggagc 360
cattctctgt gacaagatag aatgccagga tgtgctggac tgtgccgacc ctgtaacgcc 420
ccctggggaa tgctgtcctg tctgttcaca aacacctgga ggtggcaata caaattttgg 480
agaggaaga aagggacaaa agggagaacc aggattagtg cctgttgtaa caggcatacg 540
tggtcgtcca ggaccggcag gacctccagg atcacaggga ccaagaggag agcgagggcc 600
aaaaggaaga cctggccctc gtggacctca gggaattgat ggagaaccag gtgttcctgg 660
tcaacctggt gctccaggac ctcctggaca tccgtcccac ccaggacccg atggcttgag 720
caggccgttt tcagctcaaa tggctgggtt ggatgaaaaa tctggacttg ggagtcaagt 780
aggactaatg cctggctctg tgggtcctgt tggcccaagg ggaccacagg gtttacaagg 840
acagcaaggt ggtgcaggac ctacaggacc tcctggtgaa cctggtgatc ctggaccaat 900
gggtccgatt ggttcacgtg gaccagaggg ccctcctggt aaacctgggg aagatggtga 960
acctggcaga aatggaaatc ctggtgaagt gggatttgca ggatctccgg gagctcgtgg 1020
atttcctggg gctcctggtc ttccaggtct gaagggtcac cgaggacaca aaggtcttga 1080
aggccctaaa ggtgaagttg gagcacctgg ttccaagggt gaagctggcc ccactggtcc 1140
aatgggtgcc atgggtcctc tgggtccgag gggaatgcca ggagagagag ggagacttgg 1200
gccacagggt gctcctggac aacgaggtgc acatggtatg cctggaaaac ctggaccaat 1260
gggtcctctt gggataccag gctcttctgg ttttccagga aatcctggaa tgaagggaga 1320
agcaggtcct acaggggcgc gaggccctga aggtcctcag gggcagagag gtgaaactgg 1380
gcccccaggt ccagttggct ctccaggtct tcctggtgca ataggaactg atggtactcc 1440
tggtcccaaa ggcccaacgg gctctccggg tacctctggt cctcctggct cagcagggcc 1500
tcctggatct ccaggacctc agggtagcac tggtcctcag gggaattcgg gccttccggg 1560
tgatccaggt ttcaaaggag aagctggccc aaaaggggaa ccagggccac atggtattca 1620
gggtccgata ggcccacccg gtgaagaagg caaaagaggt cccagaggtg acccaggaac 1680
acttggtcct ccagggccag tgggagaaag gggtgctcct ggcaatcgtg gttttccagg 1740
ctctgatggt ttacctgggc caaagggtgc tcaaggagaa cggggtcctg taggttcttc 1800
aggacccaaa ggaagccagg gggatccagg acgtccaggg gaacctgggc ttccaggtgc 1860
tcggggtttg acaggaaatc ctggtgttca aggtcctgaa ggaaaacttg gacctttggg 1920
tgcgccaggg gaagatggcc gtccaggtcc tccaggctcc ataggaatca aagggcagcc 1980
cgggaccatg ggccttccag gccccaaagg tagcaatggt gaccctggga aacctggaga 2040
agcaggaaat cctggagttc ctgggcaaag gggagctcct ggaaaagatg gtaaagttgg 2100
tccttatggt cctcctgggc cgccgggtct acgtggtgaa agaggagaac aaggacctcc 2160
gggcccaca ggttttcagg ggcatcctgg tcctccaggt cctcctggag aaggtggaaa 2220
accaggtgat caaggtgttc ctggaggtcc cggagcagtt ggcccgttag gacctagagg 2280
agaacgagga aatcctgggg aaagaggaga acctgggata actggactcc ctggtgagaa 2340
gggaatggct ggaggacatg gtcctgatgg cccaaaaggc agtccaggtc catctgggac 2400
ccctggagat acaggcccac caggtcttca aggtatgccg ggagaaagag gaattgcagg 2460
aactcctggc cccaagggtg acagaggtgg cataggagaa aaaggtgctg aaggcacagc 2520
tggaaatgat ggtgcaggag gtcttccagg tcctttgggc cctccaggtc cggcaggcct 2580
actgggagaa aagggtgaac ctggtcctcg aggtttagtt ggtcctcctg gctcccgggg 2640
caatcctggt tctcgaggtg aaaatgggcc aactggagct gttggttttg ccggacccca 2700
ggggtctgac ggacagcctg gagtaaaagg tgaacctgga gagccaggac agaagggaga 2760
tgctggttct cctggaccac aaggtttagc aggatcccct ggccctcatg gtcctaatgg 2820
tgttcctgga ctaaaaggtg gtcgaggaac ccaaggtccg cctggtgcta caggatttcc 2880
tggttctgcg ggcagagttg gacctccagg ccctgctgga gctccaggac ctgcgggacc 2940
cctaggggaa cccgggaagg agggacctcc aggtcctcgt ggggaccctg gctctcatgg 3000
gcgtgtggga gtccgaggac cagctggccc ccctggtggc ccaggagaca aaggggaccc 3060
aggagaagat gggcaacctg gtccagatgg cccccctggt ccagctggaa cgaccgggca 3120
gagaggaatt gttggcatgc ctgggcaacg tggagagaga ggcatgcccg gcctaccagg 3180
cccagcggga acaccaggaa aagtaggacc aactggtgca acaggagata aaggtccacc 3240
tggacctgtg gggcccccag gctccaatgg tcctgtaggg gaacctggac cagaaggtcc 3300
ctggcaat gatggtaccc caggacggga tggtgctgtt ggagaacgtg gtgatcgtgg 3360
agaccctggg cctgcaggtc tgccaggctc tcagggtgcc cctggaactc ctggccctgt 3420
gggtgctcca ggagatgcag gacaaagagg agatccgggt tctcggggtc ctataggaca 3480
cctgggtcga gctggaaaac gtggattacc tggaccccaa ggacctcgtg gtgacaaagg 3540
tgatcatgga gaccgaggcg acagaggtca gaagggccac agaggcttta ctggtcttca 3600
gggtcttcct ggccctcctg gtccaaatgg tgaacaagga agtgctggaa tccctggacc 3660
atttggccca agaggtcctc caggcccagt tggtccttca ggtaaagaag gaaaccctgg 3720
gccacttggg ccattgggac ctccaggtgt acgaggcagt gtaggagaag caggacctga 3780
gggccctcct ggtgagcctg gcccacctgg ccctccgggt ccccctggcc accttacagc 3840
tgctcttggg gatatcatgg ggcactatga tgaaagcatg ccagatccac ttcctgagtt 3900
tactgaagat caggcggctc ctgatgacaa aaacaaaacg gacccagggg ttcatgctac 3960
cctgaagtca ctcagtagtc agattgaaac catgcgcagc cccgatggct cgaaaaagca 4020
cccagcccgc acgtgtgatg acctaaagct ttgccattcc gcaaagcaga gtggtgaata 4080
ctggattgat cctaaccaag gatctgttga agatgccatc aaagtttact gcaacatgga 4140
aacaggagaa acatgtattt cagcaaaccc atccagtgta ccacgtaaaa cctggtgggc 4200
cagtaaatct cctgacaata aacctgtttg gtatggtctt gatatgaaca gagggtctca 4260
gttcgcttat ggagaccacc aatcacctaa tacagccatt actcagatga cttttttgcg 4320
ccttttatca aaagaagcct cccagaacat cacttacatc tgtaaaaaca gtgtaggata 4380
catggacgat caagctaaga acctcaaaaa agctgtggtt ctcaaagggg caaatgactt 4440
agatatcaaa gcagagggaa atattagatt ccggtatatc gttcttcaag acacttgctc 4500
taagcggaat ggaaatgtgg gcaagactgt ctttgaatat agaacacaga atgtggcacg 4560
cttgcccatc atagatcttg ctcctgtgga tgttggcggc acagaccagg aattcggcgt 4620
tgaaattggg ccagtttgtt ttgtgtaaag taagccaaga cacatcgaca atgagcacca 4680
ccatcaatga ccaccgccat tcacaagaac tttgactgtt tgaagttgat cctgagactc 4740
ttgaagtaat ggctgatcct gcatcagcat tgtatatatg gtcttaagtg cctggcctcc 4800
ttatccttca gaatatttat tttacttaca atcctcaagt tttaattgat tttaaatatt 4860
tttcaataca acagtttagg tttaagatga ccaatgacaa tgaccacctt tgcagaaagt 4920
aaactgattg aataaataaa tctccgtttt cttcaattta tttcagtgta atgaaaaagt 4980
tgcttagtat ttatgaggaa attcttcttc ctggcaggta gcttaaagag tggggtatat 5040
gagccacaa cacatgttta ttttgcttgg ctgcagttga aaaatagaaa ttagtgccct 5100
tttgtgacct ctcattccaa gattgtcaat taaaaatgag tttaaaatgt ttaacttgtg 5160
atcgagacct acatgcatgt cttgatattg tgtaactata atagagactc tttaaggaga 5220
atcttaaaaa aaaaaaacgt ttctcactgt cttaaataga atttttaaat agtatatatt 5280
cagtggcatt ttggagaaca aagtgaattt acttcgactt cttaaatttt tgtaaaagac 5340
tataagttta gacatctttc tcattcaaat ttaaagatat ctttctcctc ttgatcaatc 5400
tatcaatatt gatagaagtc acactagtat ataccattta atacatttac actttcttat 5460
ttaagaagat attgaatgca aaataattga catatagaac tttacaaaca tatgtccaag 5520
gactctaaat tgagactctt ccacatgtac aatctcatca tcctgaagcc tataatgaag 5580
aaaaagatct agaaactgag ttgtggagct gactctaatc aaatgtgatg attggaatta 5640
gaccatttgg cctttgaact ttcataggaa aaatgaccca acatttctta gcatgagcta 5700
cctcatctct agaagctggg atggacttac tattcttgtt tatattttag atactgaaag 5760
gtgctatgct tctgttatta ttccaagact ggagataggc agggctaaaa aggtattatt 5820
atttttcctt taatgatggt gctaaaattc ttcctataaa attccttaaa aataaagatg 5880
gtttaatcac taccattgtg aaaacataac tgttagactt cccgtttctg aaagaaagag 5940
catcgttcca atgcttgttc actgttcctc tgtcatactg tatctggaat gctttgtaat 6000
acttgcatgc ttcttagacc agaacatgta ggtccccttg tgtctcaata cttttttttt 6060
cttaattgca tttgttggct ctattttaat ttttttcttt taaaataaac agctgggacc 6120
atcccaaaag acaagccatg catacaactt tggtcatgta tctctgcaaa gcatcaaatt 6180
aaatgcacgc ttttgtcatg tc 6202
<210>38
<211>3085
<212>DNA
<213>人
<400>38
gacggccgcc ggagccgcga ggccaactgt cgcctggttg ggcccggaaa tgggacgtcg 60
cgctttctca gggagcgtag aagcagccag ggcctctcca agccgctgct gtgacagaaa 120
gtgagtgagc tgccggagga tgtccaccgc cacgacagtc gcccccgcgg ggatcccggc 180
gaccccgggc cctgtgaacc cacccccccc ggaggtctcc aaccccagca agcccggccg 240
caagaccaac cagctgcagt acatgcagaa tgtggtggtg aagacgctct ggaaacacca 300
gttcgcctgg cccttctacc agcccgtgga cgcaatcaaa ttgaacctgc cggattatca 360
taaaataatt aaaaacccaa tggatatggg gactattaag aagagactag aaaataatta 420
ttattggagt gcaagcgaat gtatgcagga cttcaacacc atgtttacaa attgttacat 480
ttataacaag cccacagatg acatagtgct aatggcccaa gctttagaga aaatttttct 540
acaaaaagtg gcccagatgc cccaagagga agttgaatta ttaccccctg ctccaaaggg 600
caaaggtcgg aagccggctg cgggagccca gagcgcaggt acacagcaag tggcggccgt 660
gtcctctgtc tccccagcga ccccctttca gagcgtgccc cccaccgtct cccagacgcc 720
cgtcatcgct gccacccctg taccaaccat cactgcaaac gtcacgtcgg tcccagtccc 780
cccagctgcc gccccacctc ctcctgccac acccatcgtc cccgtggtcc ctcctacgcc 840
gcctgtcgtc aagaaaaagg gcgtgaagcg gaaagcagac acaaccactc ccacgacgtc 900
ggccatcact gccagccgga gtgagtcgcc cccgccgttg tcagacccca agcaggccaa 960
agtggtggcc cggcgggaga gtggtggccg ccccatcaag cctcccaaga aggacctgga 1020
ggacggcgag gtgccccagc acgcaggcaa gaagggcaag ctgtcggagc acctgcgcta 1080
ctgcgacagc atcctcaggg agatgctatc caagaagcac gcggcctacg cctggccctt 1140
ctacaagcca gtggatgccg aggccctgga gctgcacgac taccacgaca tcatcaagca 1200
cccgatggac ctcagcaccg tgaaaaggaa gatggatggc cgagagtacc cagacgcaca 1260
gggctttgct gctgatgtcc ggctgatgtt ctcgaattgc tacaaataca atcccccaga 1320
ccacgaggtt gtggccatgg cccggaagct ccaggacgtg tttgagatga ggtttgccaa 1380
gatgccagat gagcccgtgg aggcaccggc gctgcctgcc cccgcggccc ccatggtgag 1440
caagggcgct gagagcagcc gtagcagtga ggagagctct tcggactcag gcagctcgga 1500
ctcggaggag gagcgggcca ccaggctggc ggagctgcag gagcagctga aggccgtgca 1560
cgagcagctg gccgccctgt ctcaggcccc agtaaacaaa ccaaagaaga agaaggagaa 1620
gaaggagaag gagaagaaga agaaggacaa ggagaaggag aaggagaagc acaaagtgaa 1680
ggccgaggaa gagaagaagg ccaaggtggc tccgcctgcc aagcaggctc agcagaagaa 1740
ggctcctgcc aagaaggcca acagcacgac cacggccggc agacagctga agaaaggcgg 1800
caagcaggca tctgcctcct acgactcaga ggaagaggag gagggcctgc ccatgagcta 1860
atgaaaag cgccagctta gcctggacat caaccggctg cccggggaga agctgggccg 1920
ggtagtgcac atcatccaat ctcgggagcc ctcgctcagg gactccaacc ccgacgagat 1980
agaaattgac tttgagactc tgaaacccac cactttgcgg gaactggaga gatatgtcaa 2040
gtcttgttta cagaaaaagc aaaggaaacc gttctcagca agcgggaaga aacaggcagc 2100
caagtcgaaa gaggagctag ctcaggaaaa gaagaaggag ctggaaaagc gtctgcagga 2160
tgtcagcggg cagctgagca gcagcaagaa gcccgcccgg aaagagaagc ccggctcagc 2220
accctcaggg ggcccgtcca ggctcagcag cagcagctcc tccgagtctg ggagcagcag 2280
ctccagcggg tccagctctg acagcagtga ctcagaatga actggcttcg gacagaacag 2340
gacagatgga tgtcgcacac gccgagactc tgccgtaccc ctctgtggtt catattacta 2400
ttctgttcc atggtgtgca ggtctgcttc ttaattcagt gttatgatat cttccagttt 2460
ttgctttcat aggtcagaga tctatcttgt gtgtgcgtta gacttgatga gaaggtgtga 2520
actctgcaga aagtctcttc ttcatcactg aattcagtca cttggagatg acaacttcaa 2580
atgctaaccc gatgacccca gaaaaccgtg tgagattcgt accgaagaac cttgtggaat 2640
ccctttgctt aggcccaacc tggtcgatag ctcgagaaag aattttttcc aaggaaatgt 2700
ctcggatatg ggtactgtat ttgaaagctg ttagctttgt caacacgcat tgtccttgtc 2760
atttgggccc cgagctctga ccctcgtgtc tgacgcggcc acctctttct ggaggggctg 2820
aggacagatg tgcctgcttg tggagaccag gctgggccta agcgaagggt catcgcagcc 2880
ccagcccgga gcgtggagcc cttggggggt ggtcgggtgg gatgtgcgtt ctccgctcgt 2940
ggtgatgtca ggagctcctc ggagggaaca gagcggctgt gtatgcagcc tgcaggtttc 3000
catacactga agcttttacc tcaactttaa aaaaaaaaaa gaagaaaaga ttaaaaaaaa 3060
aaaaaaaaaa ctcgaggcat ctatg 3085
<210>39
<211>3120
<212>DNA
<213>人
<400>39
gagcaagccg agtggaggga ggcaaaggcc aggctgagga tcagggtggc ccgggtggca 60
gcggggaggc gctgcatgct ggaggctgtg ctgagtgccc ggtgcaggtg agccggtcct 120
gcggagttgt gccgagtgcc tgctgcagtc tcatttccag ttcctccatg acgtggcaag 180
tgaagacagg aatgaaagga atgtaaagca gcttttctct gaagagaaga agagagagag 240
acacagccaa gaccgaggct gggccaagat ggcgtctgtg tttcgaagcg aggagatgtg 300
tttgtcacaa ctgtttctcc aggtggaagc tgcatattgc tgtgtggctg agctcggaga 360
gctcggattg gttcagttca aagatttaaa tatgaatgtg aacagctttc aaaggaaatt 420
tgtgaatgaa gtcagaaggt gtgaatcact ggagagaatc ctccgttttc tggaagacga 480
gatgcaaaat gagattgtag ttcagttgct cgagaaaagc ccactgaccc cgctcccacg 540
ggaaatgatt accctggaga ctgttctaga aaaactggaa ggagagttac aggaagccaa 600
ccagaaccag caggccttga aacaaagctt cctagaactg acagaactga aatacctcct 660
agaaaacc caagacttct ttgagacgga aaccaattta gctgatgatt tctttactga 720
ggacacttct ggcctcctgg agttgaaagc agtgcctgca tatatgaccg gaaagttggg 780
gttcatagcc ggtgtgatca acagggagag gatggcttcc tttgagcggt tactgtggcg 840
aatctgccga ggaaacgtgt acttgaagtt cagtgagatg gacgcccctc tggaggatcc 900
tgtgacgaaa gaagaaattc agaagaacat attcatcata ttttaccaag gagagcagct 960
caggcagaaa atcaagaaga tctgtgatgg gtttcgagcc actgtctacc cttgcccaga 1020
gcctgcggtg gagcgcagag agatgttgga gagcgtcaat gtgaggctgg aagatttaat 1080
caccgtcata acacaaacag agtctcaccg ccagcgcctg ctgcaggaag ccgctgccaa 1140
ctggcactcc tggctcatca aggtgcagaa gatgaaagct gtctaccaca tcctgaacat 1200
gtgcaacatc gacgtcaccc agcagtgtgt catcgccgag atctggttcc cggtggcaga 1260
tgccacacgt atcaagaggg cactggagca aggcatggaa ctaagtggct cctccatggc 1320
ccccatcatg accacagtgc aatctaaaac agcccctccc acatttaaca ggaccaataa 1380
attcacagct ggcttccaga atattgttga tgcctatggt gtcggcagct accgggagat 1440
aaacccagcc ccctacacca tcatcacttt ccccttcctg ttcgctgtga tgtttggaga 1500
ctgtggtcat ggaaccgtga tgctcctggc tgcactttgg atgattctga atgagagacg 1560
cttgctctcc cagaagacag acaatgagat ttggaacacc ttcttccacg ggcgctatct 1620
gatcctactt atgggcatct tctccatcta cacgggtttg atctacaatg actgcttctc 1680
caagtccttg aacatctttg gctcttcttg gagtgtccaa cccatgttca gaaacggcac 1740
atggaatact catgtaatgg aggaaagtct atatctgcag ctggacccag ccataccagg 1800
gtgtatttt ggaaatccat acccgtttgg gattgatccg atttggaact tggcttcaaa 1860
caaactcaca tttctgaact cgtataaaat gaagatgtcg gtgatcctgg gaattgtcca 1920
gatggttttt ggtgtcatcc tcagcctttt caatcacata tacttcagaa gaactctcaa 1980
catcattctg caatttatcc ctgagatgat ttttatcctg tgtctgtttg gatacctggt 2040
tttcatgatc attttcaaat ggtgctgctt tgacgtccac gtatctcagc acgcccccag 2100
catcctcatc cacttcatca acatgtttct gtttaactac agtgactctt ccaacgcacc 2160
cctctacaaa catcagcaag aagtccaaag tttctttgtg gttatggctt tgatttctgt 2220
gccgtggatg cttctgatta agccgtttat tcttagagcc agtcatcgga aatcccagct 2280
gcaggcatcc aggatccaag aagatgccac tgagaacatt gaaggtgata gctccagccc 2340
tctagccgt tctggccaga ggacttctgc agatacccac ggggctctgg acgaccatgg 2400
agaagagttc aactttggag acgtctttgt ccaccaagcc atccacacca tcgagtactg 2460
cctgggctgc atttcaaaca cagcctccta cctgcggctc tgggccctca gcctggctca 2520
tgcacaactg tctgaagtgc tctggactat ggtgatgaac agcggccttc agacgcgagg 2580
ctggggagga atcgtcgggg tttttattat ttttgccgta tttgctgtcc tgacagtagc 2640
catccttctg atcatggagg gcctctctgc tttcctgcac gccctgcgac tgcactgggt 2700
tgagttccag aacaagttct atgtcgggga tggttacaag ttttctccat tctcctttaa 2760
acacatcctg gatggcacag ccgaggagta ggctgagggc tgcacctccc acggtggtca 2820
ccatgccaat gaaggaagtt cagtcttgtc tttgatatca gcccctgcaa ggcgctcaat 2880
gggaaggttg ttcttggctc acctgaagca tgaaactgtg tattatttgg acgtcagcct 2940
gtggatttga tacgacttaa ccacgtcaga ggaaggactt tggcaagtga tattgtcttc 3000
atgtggggta ttaattctca aataataaag taattgacaa atgaggggag aatgctaaac 3060
agatgtcttc ttgcaatatt ttaaatattg tatttgagaa aataaacatc tgagtcattc 3120
<210>40
<211>2538
<212>DNA
<213>人
<400>40
ccctcggggc tgcccctgct gcctgtgctg ttcgctcttg gggggcttct gctcctctcc 60
aatgcctcct gtgtcggggg ggtcctctgg cagcggagac tcaggcgtct tgctgaggca 120
ctcaacttcc ccccacacct tcatcctgga aggtcggaag aggaccgagt caggaacgaa 180
tatgaggaga gccagtggac aggagagcgg gacactcaga gctccacggt cagcacaaca 240
gaggcagagc cgtattaccg ctccctgagg gacttcagcc cccagctgcc cccgacgcag 300
gaggaggtgt cttattcccg aggtttcaca ggtgaagatg aggatatggc cttccctggg 360
cacttgtatg atgaggtaga aagaacgtac cccccgtctg gagcctgggg acccctctac 420
gatgaagtgc agatgggacc ctgggacctc cactggcctg aagacacata tcaggatcca 480
agaggaatct atgaccaggt ggccggagac ttggacactc tggaacccga ttctctgccc 540
ttcgagctga ggggacatct ggtatggggt ttcaaccatg ttagccaggc tggtctcaaa 600
ctcctggcct caagtgatcc acccgcctca gcctcccaaa gtgctgagat tacagagtct 660
cactctgtag tccaggttgg agtgcagtgg cgttatttcg gctcactgca tcctctgcct 720
cctggttcaa gagattctct tgcctcagcc tcccgcatag ctgggattac agcaccttgg 780
gaggcagagg tgagcagatc acctcagggc actcaggatt ccccagtgac caggtctggt 840
cccccctcca ggggctggca gtccctgagc tttgatggcg gggccttcca ccttaagggc 900
acaggagagc tgacacgggc cttgctggtt ctccggctgt gtgcctggcc cccactcgtc 960
actcacgggc tgttgctcca ggcctggtct cggcgactcc tgggctcccg gctctcaggc 1020
gcatttctcc gagcatccgt ctatgggcag tttgtggctg gtgagacagc agaggaggtg 1080
aagggctgcg tgcagcagct gcggaccctc agcctccgac cactgctggc agtgcccact 1140
gaggaggagc cggactctgc tgccaagagg atgaggcttc accatgttgg ccaggctggt 1200
cttgaactcc tgaccccagc ggcatctggc tctgttgccc aggctggagt gcagtggaga 1260
caatcctctg acaggggagg aggaaaccag gctgctgcct ccaggtcttc ccttctccag 1320
gaggcagcat tctccccacc atgcggaagg ttgcagcttc cagcccaacc tgcctccaga 1380
cacggtgcta ggggccgagg aagcatgaag gcaaaatccc tgacctcgag gcacttactt 1440
gcaagtcagg ggcaagagac aataattaaa accaaagtca gaatcccagc actttggaag 1500
gctgagcctg ggcaacacag caagaccccg tctcagcaaa acaaaagtca gtacgtaaca 1560
acactttggg aggccgatgt gggcagatca cttgagaacc tccaggtctc ctgcctcaat 1620
gctgagcaga accagcacct ccgggcctcc ctcagccgcc tgcatcgggt ggcacaggta 1680
acccctcctg ctggaaccag cacctccggg cctccctctg ccgcctgcat tgggtggcac 1740
agccgcctgc atcgggtggc acagtatgcc cgggcccagc acgtgcggct cctggtggat 1800
gcggagtaca cctcactgaa ccctgcgctc tcgctgctgg tggctgccct ggctgtgcgc 1860
tggaacagcc cgggtgaagg cgggccctgg gtgtggaaca cctaccaggc ctgtctaaag 1920
gacacattcg agcggctggg gagggatgca gaggctgcgc acagggccgg cctggccttc 1980
ggagtgaagc tggtacgagg tgcatatctg gacaaggaga gagcggtggc ccagctccat 2040
gggatggaag accccactca gcctgactat gaggccacca gtgagctgaa cagagcatct 2100
cccttcagtt acagccgctg cctggaactg atgctgacgc acgtggcccg ccatggcccc 2160
atgtgccacc tcatggtggc ttcccacaat gaggaatctg ttcgccaggc aaccaagcgc 2220
atgtgggagc tgggcattcc tctggatggg actgtctgtt tcggacaact tctgggcatg 2280
tgtgaccacg tctctctagc actggggcag gccggctatg tagtgtataa gtccattccc 2340
tatggctcct tggaggaggt aatcccctac ctgatccgga gggcccagga gaaccggagc 2400
gtgcttcagg gtgcccgcag ggaacaggag ctgctcagcc aagaactgtg gcggcggctg 2460
ctgccaggat gccgaaggat accccactag cacccctgag ggggtcatgt ggtcaataaa 2520
agtccttagg tgctgcct 2538
<210>41
<211>4737
<212>DNA
<213>人
<400>41
gccccgggaa gcgcagccat ggctctgcgg aggctggggg ccgcgctgct gctgctgccg 60
ctgctcgccg ccgtggaaga aacgctaatg gactccacta cagcgactgc tgagctgggc 120
tggatggtgc atcctccatc agggtgggaa gaggtgagtg gctacgatga gaacatgaac 180
acgatccgca cgtaccaggt gtgcaacgtg tttgagtcaa gccagaacaa ctggctacgg 240
accaagttta tccggcgccg tggcgcccac cgcatccacg tggagatgaa gttttcggtg 300
cgtggctgca gcagcatccc cagcgtgcct ggctcctgca aggagacctt caacctctat 360
tactatgagg ctgactttga ctcggccacc aagaccttcc ccaactggat ggagaatcca 420
tgggtgaagg tggataccat tgcagccgac gagagcttct cccaggtgga cctgggtggc 480
ggcgtcatga aaatcaacac cgaggtgcgg agcttcggac ctgtgtcccg cagcggcttc 540
tacctggcct tccaggacta tggcggctgc atgtccctca tcgccgtgcg tgtcttctac 600
cgcaagtgcc cccgcatcat ccagaatggc gccatcttcc aggaaaccct gtcgggggct 660
gagagcacat cgctggtggc tgcccggggc agctgcatcg ccaatgcgga agaggtggat 720
gtacccatca agctctactg taacggggac ggcgagtggc tggtgcccat cgggcgctgc 780
atgtgcaaag caggcttcga ggccgttgag aatggcaccg tctgccgagg ttgtccatct 840
gggactttca aggccaacca aggggatgag gcctgtaccc actgtcccat caacagccgg 900
accacttctg aaggggccac caactgtgtc tgccgcaatg gctactacag agcagacctg 960
gaccccctgg acatgccctg cacaaccatc ccctccgcgc cccaggctgt gatttccagt 1020
gtcaatgaga cctccctcat gctggagtgg acccctcccc gcgactccgg aggccgagag 1080
gacctcgtct acaacatcat ctgcaagagc tgtggctcgg gccggggtgc ctgcacccgc 1140
tgcggggaca atgtacagta cgcaccacgc cagctaggcc tgaccgagcc acgcatttac 1200
atcagtgacc tgctggccca cacccagtac accttcgaga tccaggctgt gaacggcgtt 1260
actgaccaga gccccttctc gcctcagttc gcctctgtga acatcaccac caaccaggca 1320
gctccatcgg cagtgtccat catgcatcag gtgagccgca ccgtggacag cattaccctg 1380
tcgtggtccc agccggacca gcccaatggc gtgatcctgg actatgagct gcagtactat 1440
gagaaggagc tcagtgagta caacgccaca gccataaaaa gccccaccaa cacggtcacc 1500
gtgcagggcc tcaaagccgg cgccatctat gtcttccagg tgcgggcacg caccgtggca 1560
ggctacgggc gctacagcgg caagatgtac ttccagacca tgacagaagc cgagtaccag 1620
acaagcatcc aggagaagtt gccactcatc atcggctcct cggccgctgg cctggtcttc 1680
ctcattgctg tggttgtcat cgccatcgtg tgtaacagaa gacgggggtt tgagcgtgct 1740
gactcggagt acacggacaa gctgcaacac tacaccagtg gccacatgac cccaggcatg 1800
aagatctaca tcgatccttt cacctacgag gaccccaacg aggcagtgcg ggagtttgcc 1860
aaggaaattg acatctcctg tgtcaaaatt gagcaggtga tcggagcagg ggagtttggc 1920
gaggtctgca gtggccacct gaagctgcca ggcaagagag agatctttgt ggccatcaag 1980
acgctcaagt cgggctacac ggagaagcag cgccgggact tcctgagcga agcctccatc 2040
atgggccagt tcgaccatcc caacgtcatc cacctggagg gtgtcgtgac caagagcaca 2100
cctgtgatga tcatcaccga gttcatggag aatggctccc tggactcctt tctccggcaa 2160
aacgatgggc agttcacagt catccagctg gtgggcatgc ttcggggcat cgcagctggc 2220
gtgaagtacc tggcagacat gaactatgtt caccgtgacc tggctgcccg caacatcctc 2280
gtcaacagca acctggtctg caaggtgtcg gactttgggc tctcacgctt tctagaggac 2340
gatacctcag accccaccta caccagtgcc ctgggcggaa agatccccat ccgctggaca 2400
gccccggaag ccatccagta ccggaagttc acctcggcca gtgatgtgtg gagctacggc 2460
attgtcatgt gggaggtgat gtcctatggg gagcggccct actgggacat gaccaaccag 2520
gatgtaatca atgccattga gcaggactat cggctgccac cgcccatgga ctgcccgagc 2580
gccctgcacc aactcatgct ggactgttgg cagaaggacc gcaaccaccg gcccaagttc 2640
ggccaaattg tcaacacgct agacaagatg atccgcaatc ccaacagcct caaagccatg 2700
gcgcccctct cctctggcat caacctgccg ctgctggacc gcacgatccc cgactacacc 2760
agctttaaca cggtggacga gtggctggag gccatcaaga tggggcagta caaggagagc 2820
ttcgccaatg ccggcttcac ctcctttgac gtcgtgtctc agatgatgat ggaggacatt 2880
ctccgggttg gggtcacttt ggctggccac cagaaaaaaa tcctgaacag tatccaggtg 2940
atgcgggcgc agatgaacca gattcagtct gtggaggttt gacattcacc tgcctcggct 3000
cacctcttcc tccaagcccc gccccctctg ccccacgtgc cggccctcct ggtgctctat 3060
ccactgcagg gccagccact cgccaggagg ccacgggcca cgggaagaac caagcggtgc 3120
cagccacgag acgtcaccaa gaaaacatgc aactcaaacg acggaaaaaa aaagggaatg 3180
ggaaaaaaga aaacagatcc tgggaggggg cgggaaatac aaggaatatt ttttaaagag 3240
gattctcata aggaaagcaa tgactgttct tgcgggggat aaaaaagggc ttgggagatt 3300
catgcgatgt gtccaatcgg agacaaaagc agtttctctc caactccctc tgggaaggtg 3360
acctggccag agccaagaaa cactttcaga aaaacaaatg tgaaggggag agacaggggc 3420
cgcccttggc tcctgtccct gctgctcctc taggcctcac tcaacaacca agcgcctgga 3480
ggacgggaca gatggacaga cagccaccct gagaacccct ctgggaaaat ctattcctgc 3540
caccactggg caaacagaag aatttttctg tctttggaga gtattttaga aactccaatg 3600
aaagacactg tttctcctgt tggctcacag ggctgaaagg ggcttttgtc ctcctgggtc 3660
agggagaacg cggggacccc agaaaggtca gccttcctga ggatgggcaa cccccaggtc 3720
tgcagctcca ggtacatatc acgcgcacag cctggcagcc tggccctcct ggtgcccact 3780
cccgccagcc cctgcctcga ggactgatac tgcagtgact gccgtcagct ccgactgccg 3840
ctgagaaggg ttgatcctgc atctgggttt gtttacagca attcctggac tcgggggtat 3900
tttggtcaca gggtggtttt ggtttagggg gtttgtttgt tgggttgttt tttgtttttt 3960
ggtttttttt aatgacaatg aagtgacact ttgacatttc ctaccttttg aggacttgat 4020
ccttctccag gaagaaggtg ctttctgctt actgacttag gcaatacacc aagggcgaga 4080
ttttatatgc acatttctgg atttttttat acggttttca ttgacactct tccctcctcc 4140
cacctgccac caggcctcac caaagcccac tgccatgggg ccatctgggc cattcagaga 4200
ctggagtgag atttgggtgt ggagggggag gcgccaaggt ggaggagctt cccactccag 4260
gactgttgat gaaagggaca gattgaggag gaagtgggct ctgaggctgc agggctggaa 4320
gtccttgccc acttcccact ctcctgcccc aatctatcta gtacttccca ggcaaatagg 4380
cccctttgag gctcctgagt gccctcagat ggtcaaaacc cagttttccc tctgggagcc 4440
taaaccaggc tgcatcggag gccaggaccc ggatcattca ctgtgatacc ctgccctcca 4500
gagggtgcgc tcagagacac gggcaagcat gcctcttccc ttccctggag agaaagtgtg 4560
tgatttctct cccacctcct tccccccacc agacctttgc tgggcctaaa ggtcttggcc 4620
atggggacgc cctcagtcta gggatctggc cacagactcc ctcctgtgaa ccaacacaga 4680
cacccaagca gagcaatcag ttagtgaatt gaatggaaat aaacgcttta gttataa 4737
<210>42
<211>1505
<212>DNA
<213>人
<400>42
agctgcggcg ctgggctggc ggcggcgagt ccacgtgctc cccgcggccg gttgaaaccg 60
ttggcgggcg ctggctgaga ggcaatgttt gctgtcttcc attggagtga ctgaatttct 120
acatgacggc tttttgacaa gacttaaaac ctgtcttgga tagagaatat ttagccattt 180
acctaaaaat ggtatttttt acatgcaatg catgtggtga atcagtgaag aaaatacaag 240
tggaaaagca tgtgtctgtt tgcagaaact gtgaatgcct ttcttgcatt gactgcggta 300
aagatttctg gggcgatgac tataaaaacc acgtgaaatg cataagtgaa gatcagaagt 360
atggtggcaa aggctatgaa ggtaaaaccc acaaaggcga catcaaacag caggcgtgga 420
ttcagaaaat tagtgaatta ataaagagac ccaatgtcag ccccaaagtg agagaacttt 480
tagagcaaat tagtgctttt gacaacgttc ccaggaaaaa ggcaaaattt cagaattgga 540
tgaagaacag tttaaaagtt cataatgaat ccattctgga ccaggtgtgg aatatctttt 600
ctgaagcttc caacagcgaa ccagtcaata aggaacagga tcaacggcca ctccacccag 660
tggcaaatcc acatgcagaa atctccacca aggttccagc ctccaaagtg aaagacgccg 720
tggaacagca aggggaggtg aagaagaata aaagagaaag aaaggaagaa cggcagaaga 780
aaaggaaaag agaaaagaaa gaactaaagt tagaaaacca ccaggaaaac tcaaggaatc 840
agaagcctaa gaagcgcaaa aagggacagg aggctgacct tgaggctggt ggggaggaag 900
tccctgaggc caatggctct gcagggaaga ggagcaagaa gaagaagcag cgcaaggaca 960
gcgccagtga ggaagaggca cgcgtgggcg cagggaagag gaagcggagg cactcggaag 1020
ttgaaacaga ttctaagaag aaaaagatga agctcccaga gcatcctgag ggcggagaac 1080
cagaagacga tgaggctcct gcaaaaggta aattcaactg gaagggaact attaaagcaa 1140
ttctgaaaca ggccccagac aatgaaataa ccatcaaaaa gctaaggaaa aaggttttag 1200
ctcagtacta cacagtgaca gatgagcatc acagatccga agaggaactc ctggtcatct 1260
ttaacaagaa aatcagcaag aaccctacct ttaagttatt aaaggacaaa gtcaagcttg 1320
tgaaatgaac atttgtgtat ttaaaaattg aatccattct gctgacttct tcctttcact 1380
gctgtttata aaatgtgtaa tgaattctaa caactcaaat tttgcttttt gaagctgtat 1440
ttttaagtta agaaaatata tttttggtat aacttttatg agaaaaataa aatatattct 1500
ggtcc 1505
<210>43
<211>557
<212>DNA
<213>人
<400>43
cctcctggga gggagctgaa gccgctcgca agactcccgt agtccccacc tctctcagct 60
tccggctggt agtagttccg cttcctgtcc gactgtggtg tctttgctga gggtcacatt 120
gagctgcagg ttgaatccgg ggtgccttta ggattcagca ccatggcgga agacatggag 180
accaaaatca agaactacaa gaccgcccct tttgacagcc gcttccccaa ccagaaccag 240
actagaaact gctggcagaa ctacctggac ttccaccgct gtcagaaggc aatgaccgct 300
aaaggaggcg atatctctgt gtgcgaatgg taccagcgtg tgtaccagtc cctctgcccc 360
acatcctggg tcacagactg ggatgagcaa cgggctgaag gcacgtttcc cgggaagatc 420
tgaactggct gcatctccct ttcctctgtc ctccatcctt ctcccaggat ggtgaagggg 480
gacctggtac ccagtgatcc ccaccccagg atcctaaatc atgacttacc tgctaataaa 540
aactcattgg aaaagtg 557
<210>44
<211>662
<212>DNA
<213>人
<400>44
ggggggggga gcacaaagtt gggagtgaca ccagagcctc ctgcaagatg cttctgattc 60
tgctgtcagt ggccctgctg gccttcagct cagctcagga tttaaatgaa gatgtcagcc 120
aggaagatgt tcccctcgta atatcagatg gaggagactc tgagcagttc atagatgagg 180
agcgtcaggg accacctttg ggaggacagc aatctcaacc ctctgctggt gatgggaacc 240
aggatgatgg ccctcagcag ggaccacccc aacaaggagg ccagcagcaa caaggtccac 300
cacctcctca gggaaagcca caaggaccac cccaacaggg aggccatccc cctcctcctc 360
aaggaaggcc acaaggacca ccccaacagg gaggccatcc ccgtcctcct cgaggaaggc 420
cacaaggacc accccaacag ggaggccatc agcaaggtcc tcccccacct cctcctggaa 480
agccccaggg accacctccc caagggggcc gcccacaagg acctccacag gggcagtctc 540
ctcagtaatc caggattcaa tgacaggaag tgaataagaa gataacagtg tttcaaatgc 600
cgtgaaacat ggcatcatgc tctaacttca gtataccaat aaaacaatca gcttgcaatt 660
tc 662
<210>45
<211>2232
<212>DNA
<213>人
<400>45
tttccccttc tctgccctgc tccaggcacc aggctctttc cccttcagtg tctcagagga 60
ggggacggca gcaccatgga cccccgcttg tccactgtcc gccagacctg ctgctgcttc 120
aatgtccgca tcgcaaccac cgccctggcc atctaccatg tgatcatgag cgtcttgttg 180
ttcatcgagc actcagtaga ggtggcccat ggcaaggcgt cctgcaagct ctcccagatg 240
ggctacctca ggatcgctga cctgatctcc agcttcctgc tcatcaccat gctcttcatc 300
atcagcctga gcctactgat cggcgtagtc aagaaccggg agaagtacct gctgcccttc 360
ctgtccctgc aaatcatgga ctatctcctg tgcctgctca ccctgctggg ctcctacatt 420
gagctgcccg cctacctcaa gttggcctcc cggagccgtg ctagctcctc caagttcccc 480
ctgatgacgc tgcagctgct ggacttctgc ctgagcatcc tgaccctctg cagctcctac 540
atggaagtgc ccacctatct caacttcaag tccatgaacc acatgaatta cctccccagc 600
caggaggata tgcctcataa ccagttcatc aagatgatga tcatcttttc catcgccttc 660
atcactgtcc ttatcttcaa ggtctacatg ttcaagtgcg tgtggcggtg ctacagattg 720
atcaagtgca tgaactcggt ggaggagaag agaaactcca agatgctcca gaaggtggtc 780
ctgccgtcct acgaggaagc cctgtctttg ccatcgaaga ccccagaggg gggcccagca 840
ccacccccat actcagaggt gtgaccctcg ccaggcccca gccccagtgc tgggaggggt 900
ggagctgcct cataatctgc ttttttgctt tggtggcccc tgtggcctgg gtgggccctc 960
ccgcccctcc ctggcaggac aatctgcttg tgtctccctc gctggcctgc tcctcctgca 1020
gggcctgtga gctgctcaca actgggtcaa cgctttaggc tgagtcactc ctcgggtctc 1080
tccataattc agcccaacaa tgcttggttt atttcaatca gctctgacac ttgtttagac 1140
gattggccat tctaaagttg gtgagtttgt caagcaacta tcgacttgat cagttcagcc 1200
aagcaactga caaatcaaaa acccacttgt cagttcagta aaataatttg gtcaaacaac 1260
agtctattgc attgatttat aaatagttgt cagttcacat agcaatttaa tcaagtaatc 1320
attaattagt taccccctat atataaatat atgtaatcaa tttcttcaaa tagcttgctt 1380
acatgataat caattagcca accatgagtc atttagaata gtgataaata gaatacacag 1440
aatagtgatg aaattcaatt taaaaaatca cgttagcctc caaaccattt aattcaaatg 1500
aacccatcaa ctggatgcca actctggcga atgtaggacc tctgagtggc tgtataattg 1560
ttaattcaaa tgaaattcat ttaaacagtt gacaaactgt cattcaacaa ttagctccag 1620
gaaataacag ttatttcatc ataaaacagt cccttcaaac acacaattgt tctgctgaag 1680
agttgtcatc aacaatccaa tgctcaccta ttcagttgct ctgtggtcag tgtggctgca 1740
tagcagtgga ttccatgaaa ggagtcattt tagtgatgag ctgccagtcc attcccaggc 1800
caggctgtcg ctggccatcc attcagtcga ttcagtcata ggcgaatctg ttctgcccga 1860
ggcttgtggt caagcaaaaa ttcagccctg aaatcaggca catctgttcg ttggactaaa 1920
cccacaggtt agttcagtca aagcaggcaa cccccttgtg ggcactgacc ctgccactgg 1980
ggtcatggcg gttgtggcag ctggggaggt ttggccccaa cagccctcct gtgcctgctt 2040
ccctgtgtgt cggggtcctc cagggagctg acccagaggt ggaggccacg gaggcagggt 2100
ctctggggac tgtcgggggg tacagaggga gaaggctctg caagagctcc ctggcaatac 2160
ccccttgtgt aattgctttg tgtgcgacag ggaggaagtt tcaataaagc aacaacaagc 2220
ttcaaggaat tc 2232
<210>46
<211>3136
<212>DNA
<213>人
<400>46
gaagcgcccg ccccggccgg agccgccatg taaccggcgc cgcccggagc ccgagccgcg 60
cgggccccag cgacccgccc gccatggggg acgaggacga cgatgagagc tgcgccgtgg 120
agctgcggat cacagaagcc aacctgaccg ggcacgagga gaaggtgagc gtggagaact 180
tcgagctgct caaggtgctg ggcacgggag cctacggcaa ggtgttcctg gtgcggaagg 240
cgggcgggca cgacgcgggg aagctgtacg ccatgaaggt gctgcgcaag gcggcgctgg 300
tgcagcgcgc caagacgcaa gagcacacgc gcaccgagcg ctcggtgctg gagctggtgc 360
gccaggcgcc cttcctggtc acgctgcact acgctttcca gacggatgcc aagctgcacc 420
tcatcctgga ctatgtgagc ggcggggaga tgttcaccca cctctaccag cgccagtact 480
tcaaggaggc tgaggtgcgc gtgtatgggg gtgagatcgt gctggccctg gaacacctgc 540
acaagctcgg catcatttac cgagacctga aactggagaa tgtgctgctg gactccgagg 600
gccacattgt cctcacggac ttcgggctga gcaaggagtt cctgacggag gagaaagagc 660
ggaccttctc cttctgtggc accatcgagt acatggcccc cgaaatcatc cgtagcaaga 720
cggggcatgg caaggctgtg gactggtgga gcctgggcat cttgctcttc gagctgctga 780
gggggcctc gcccttcacc ctggagggcg agaggaacac gcaggctgag gtgtctcgac 840
ggatcctgaa gtgctcccct cccttccccc ctcggatcgg gcccgtggcg caggacctgc 900
tgcagcggct gctttgtaag gatcctaaga agcgattggg cgcggggccc cagggggcac 960
aagaagtccg gaaccatccc ttcttccagg gcctcgattg ggtggctctg gctgccagga 1020
agattccagc cccattccgg ccccaaatcc gctcagagct ggatgtgggc aactttgcgg 1080
aggaattcac tcggctggag cctgtctact caccccctgg cagcccccca cctggggacc 1140
cccgaatctt tcagggatac tcctttgtgg caccctccat tctctttgac cacaacaacg 1200
cggtgatgac cgatgggctg gaagcgcctg gtgctggaga ccggccaggt cgggcagcgg 1260
tggccaggag cgctatgatg caggactcgc ccttcttcca gcagtacgag ctggacctgc 1320
gggagcctgc gctgggccag ggcagctttt ctgtgtgtcg ccgctgccgc cagcgccaga 1380
gcggccagga gttcgcagtc aagatcctca gtcgcaggct ggaggcgaac acgcagcgcg 1440
aagtggctgc cctgcgcctg tgccagtcac accccaacgt ggtgaatctg cacgaggtgc 1500
atcacgacca gctgcacacg tacctggtcc tggagctgct gcggggcggg gagctgctgg 1560
agcacatccg caagaagcgg cacttcagcg agtcggaagc aagccagatc ctgcgcagcc 1620
tcgtgtcggc cgtgagcttc atgcacgagg aggcgggcgt ggtgcaccgc gacctcaagc 1680
cggagaacat cctgtacgcc gacgacacgc ccggggcccc ggtgaaaatc atcgacttcg 1740
ggttcgcgcg gttgcggccg cagagtcccg gggtgcccat gcagacgccc tgcttcacgc 1800
tgcagtacgc tgcccccgag ctgctggcgc agcagggcta cgacgagtcc tgcgacctct 1860
ggagcctggg cgtcattctg tacatgatgc tgtcggggca ggtccccttc cagggggcct 1920
ctggccaggg cgggcagagc caggcggccg agatcatgtg caaaatccgc gaggggcgct 1980
tctcccttga cggggaggcc tggcagggtg tatccgagga agccaaggag ctggtccgag 2040
ggctcctgac cgtggacccc gccaagcggc tgaagctcga gggactgcgg ggcagctcgt 2100
ggctgcagga cggcagcgcg cgctcctcgc ccccgctccg gacgcccgac gtgctcgagt 2160
cctctgggcc cgcagtgcgc tcgggtctca acgccacctt catggcattc aaccggggca 2220
agcgggaggg cttcttcctg aagagcgtgg agaatgcacc cctggccaag cggcggaagc 2280
agaagctgcg gagcgccacc gcctcccgcc ggggctcccc tgcaccagcc aacccgggcc 2340
gagcccccgt cgcctccaaa ggggcccccc gccgagccaa cggccccctg cccccctcct 2400
aatccccacc actgtgaccc ccttccctca taggggctgt gacctgggag cccggctcac 2460
tcccggaggc ctctgcctgc ggctgacctg atccccaagg gactgtcctt tcctctccta 2520
ccccacccca ctcccagaca gagcagaagt atttttataa gcagagaatt ttttatgtct 2580
taccagatag agttgcaggg aagggggggc ctgctgggga gtggggtttg gggggccctc 2640
tcccaggaca ctgcctcttc tgggcagaag gcccctccag ggggactgct ccaacaggaa 2700
agagcccctc ccccacttct aagcactgag ttaggagtgc taactcctaa actgggaccc 2760
cctaccctgt tctcccctga ggccccgttc ctgggagggg cacccctcaa ctgtcacttt 2820
atggactgtc tgtgcaatta cgtccaccaa agacccgtgt tgggggtact gaaggagagg 2880
ccctggggga ccctctgaag catttctgcc tcactttatg tcatctgctt ctcccctgtt 2940
ggggctaagg aaggagatag gtggctccta aaagaggagg ccatcttctc acccacccct 3000
tcctctttgg cacagctact cctggctggg ggtggggcct tgggggtctg ggctgggcat 3060
ccatggtcac tgcctcagcc cagccaggct gtgcctttga ctttaaaata aaagtccacc 3120
cagtgctgtg tgtggc 3136
<210>47
<211>6918
<212>DNA
<213>人
<400>47
ctttgacctg cagtagagcc tacgtcagag gctggcgcaa acagaagtgc agcggtggcg 60
gcggctggtt gcgggccggc ggcgggctgg cggagatgga ggatcttgtt caagatgggg 120
tggcttcacc agctacccct gggaccggga aatctaagct ggaaacattg cccaaagaag 180
acctcatcaa gtttgccaag aaacagatga tgctaataca gaaagctaaa tcaaggtgta 240
cagaattgga gaaagaaatt gaagaactca gatcaaaacc tgttactgaa ggaactggtg 300
atattattaa ggcattaact gaacgtctgg atgctcttct tctggaaaaa gcagagactg 360
agcaacagtg tctttctctg aaaaaggaaa atataaaaat gaagcaagag gttgaggatt 420
ctgtaacaaa gatgggagat gcacataagg agttggaaca atcacatata aactatgtga 480
aagaaattga aaatttgaaa aatgagttga tggcagtacg ttccaaatac agtgaagaca 540
aagctaactt acaaaagcag ctggaagaag caatgaatac gcaattagaa ctttcagaac 600
aacttaaatt tcagaacaac tctgaagata atgttaaaaa actacaagaa gagattgaga 660
aaattaggcc aggctttgag gagcaaattt tatatctgca aaagcaatta gacgctacca 720
ctgatgaaaa gaaggaaaca gttactcaac tccaaaatat cattgaggct aattctcagc 780
attaccaaaa aaatattaat agtttgcagg aagagctttt acagttgaaa gctatacacc 840
aagaagaggt gaaagagttg atgtgccaga ttgaagcatc agctaaggaa catgaagcag 900
agataaataa gttgaacgag ctaaaagaga acttagtaaa acaatgtgag gcaagtgaaa 960
agaacatcca gaagaaatat gaatgtgagt tagaaaattt aaggaaagcc acctcaaatg 1020
caaaccaaga caatcagata tgttctattc tcttgcaaga aaatacattt gtagaacaag 1080
tagtaaatga aaaagtcaaa cacttagaag ataccttaaa agaacttgaa tctcaacaca 1140
gtatcttaaa agatgaggta acttatatga ataatcttaa gttaaaactt gaaatggatg 1200
ctcaacatat aaaggatgag ttttttcatg aacgggaaga cttagagttt aaaattaatg 1260
aattattact agctaaagaa gaacagggct gtgtaattga aaaattaaaa tctgagctag 1320
caggtttaaa taaacagttt tgctatactg tagaacagca taacagagaa gtacagagtc 1380
ttaaggaaca acatcaaaaa gaaatatcag aactaaatga gacatttttg tcagattcag 1440
aaaaagaaaa attaacatta atgtttgaaa tacagggtct taaggaacag tgtgaaaacc 1500
tacagcaaga aaagcaagaa gcaattttaa attatgagag tttacgagag attatggaaa 1560
ttttacaaac agaactgggg gaatctgctg gaaaaataag tcaagagttc gaatcaatga 1620
agcaacagca agcatctgat gttcatgaac tgcagcagaa gctcagaact gcttttactg 1680
aaaaagatgc ccttctcgaa actgtgaatc gcctccaggg agaaaatgaa aagttactat 1740
ctcaacaaga attggtacca gaacttgaaa ataccataaa gaaccttcaa gaaaagaatg 1800
gagtatactt acttagtctc agtcaaagag ataccatgtt aaaagaatta gaaggaaaga 1860
taaattctct tactgaggaa aaagatgatt ttataaataa actgaaaaat tcccatgaag 1920
aaatggataa tttccataag aaatgtgaaa gggaagaaag attgattctt gaacttggga 1980
agaaagtaga gcaaacaatc cagtacaaca gtgaactaga acaaaaggta aatgaattaa 2040
caggaggact agaggagact ttaaaagaaa aggatcaaaa tgaccaaaaa ctagaaaaac 2100
ttatggttca aatgaaagtt ctctctgaag acaaagaagt attgtcagct gaagtgaagt 2160
ctctttatga ggaaaacaat aaactcagtt cagaaaaaaa acagttgagt agggatttgg 2220
aggttttttt gtctcaaaaa gaagatgtta tccttaaaga acatattact caattagaaa 2280
agaaacttca gttaatggtt gaagagcaag ataatttaaa taaactgctt gaaaatgagc 2340
aagttcagaa gttatttgtt aaaactcagt tgtatggttt tcttaaagaa atgggatcag 2400
aagtttcaga agacagtgaa gagaaagatg ttgttaatgt cctacaggca gtcggtgaat 2460
ccttggcaaa aataaatgag gaaaaatgca acctggcttt tcagcgtgat gaaaaagtat 2520
tagagttaga aaaagagatt aagtgccttc aagaagagag tgtagttcag tgtgaagaac 2580
ttaagtcttt attgagagac tatgagcaag agaaagttct cttaaggaaa gagttagaag 2640
aaatacagtc agaaaaagag gccctgcagt ctgatcttct agaaatgaag aatgctaatg 2700
aaaaaacaag gcttgaaaat cagaatcttt taattcaagt tgaagaagta tctcaaacat 2760
gtagcaaaag tgaaatccat aatgaaaaag aaaaatgttt tataaaggaa catgaaaacc 2820
taaagccact actagaacaa aaagaattac gagataggag agcagagttg atactattaa 2880
aggattcctt agcaaaatca ccttctgtaa aaaatgatcc tctgtcttca gtaaaagagt 2940
tggaagaaaa aatagaaaat ctggaaaaag aatgcaaaga aaaggaggag aaaataaata 3000
agataaaatt agttgccgta aaggcaaaga aagaactaga ttccagcaga aaagagaccc 3060
agactgtgaa ggaagaactt gaatctcttc gatcagaaaa ggaccagtta tctgcttcca 3120
tgagagatct cattcaagga gcagaaagct ataagaatct tttattagaa tatgaaaagc 3180
agtcagagca actggatgtg gaaaaagaac gtgctaataa ttttgagcat cgtattgaag 3240
accttacaag acaattaaga aattcgactt tgcagtgtga aacaataaat tctgataatg 3300
aagatctcct ggctcgtatt gagacattac agtctaatgc caaattatta gaagtacaga 3360
ttttagaagt ccagagagcc aaagcaatgg tagacaaaga attagaagct gaaaaacttc 3420
agaaagaaca gaagataaag gaacatgcca ctactgtaaa tgaacttgaa gaacttcagg 3480
tacaacttca aaaggaaaag aaacagcttc agaaaaccat gcaagaatta gagctggtta 3540
aaaaggatgc ccaacaaacc acattgatga atatggaaat agctgattat gaacgtttga 3600
tgaaagaact aaatcaaaag ttaactaata aaaacaacaa gatagaagat ttggagcaag 3660
aaataaaaat tcaaaaacag aaacaagaaa ccctacaaga agaaataact tcattacagt 3720
cttcagtaca acaatatgaa gaaaaaaaca ccaaaatcaa gcaattgctt gtgaaaacca 3780
aaaaggaact ggcagattca aagcaagcag aaactgatca cttaatactt caagcatctt 3840
taaaaggtga gctggaggca agccagcagc aagtagaagt ctataaaata cagctggctg 3900
aaataacatc agagaagcac aaaatccacg agcacctgaa aacctctgcg gaacagcacc 3960
agcgtacgct aagtgcatac cagcagagag tgacagcact acaggaagag tgccgtgctg 4020
ccaaggcaga acaagctact gtaacctctg aattcgagag ctacaaagtc cgagttcata 4080
ttgttctaaa acaacagaaa aataaatcta tgtctcaggc tgaaactgag ggcgctaaac 4140
aagaaaggga acatctggaa atgctgattg accagctaaa aatcaaatta caagatagcc 4200
aaaataactt acagattaat gtatctgaac ttcaaacatt gcagtctgaa catgatacac 4260
tgctagaaag gcacaacaag atgctgcagg aaactgtgtc caaagaggcg gaactccggg 4320
aaaaattgtg ttcaatacag tcagagaaca tgatgatgaa atctgaacat acacagactg 4380
tgagtcagct aacatcccag aacgaggtcc ttcgaaatag cttccgagat caagtgcgac 4440
atttgcagga agaacacaga aagacagtgg agacattaca gcagcagctc tccaagatgg 4500
aagcacagct cttccagctt aagaatgaac cgaccacaag aagcccagtt tcctctcaac 4560
aatctttgaa gaaccttcga gaaaggagaa acacagacct cccgcttcta gacatgcaca 4620
ctgtaacccg ggaagaggga gaaggcatgg agacaactga tacggagtct gtgtcttccg 4680
ccagcacata cacacagtct ttagagcagc tgcttaactc tcccgaaact aaacttgagc 4740
ctccattatg gcatgctgaa tttaccaaag aagaattggt tcagaagctc agttccacca 4800
caaaaagtgc agatcactta aacggcctgc ttcgggaaac agaagcaacc aatgcaattc 4860
ttatggagca aattaagctt ctcaaaagtg aaataagaag attggaaagg aatcaagagc 4920
gagagaagtc tgcagctaac ctggaatact tgaagaacgt cttgctgcag ttcattttct 4980
tgaaaccagg tagtgaaaga gagagacttc ttcctgttat aaatacgatg ttgcagctca 5040
gccctgaaga aaagggaaaa cttgctgcgg ttgctcaagg tgaggaagaa aatgcttccc 5100
gttcttctgg atgggcatcc tatcttcata gttggtctgg acttcgatag gttgatggaa 5160
ggaatatttt tattaaccaa atagaatcta tttacaaaaa tggttcacgt atattaccac 5220
aattcttttg tcaaaaagtg tgtatatatg tttgcatcta catatatttg tacatctata 5280
tgacagatgt attttaaaag tttcatcttg aagtaaaagt acaacagctt gaagtgttga 5340
tagcaggcca cagccctcta actcatgtga tttcccatgc atgctgccag aataaaacca 5400
ccaggaatga attcactccc cacttctctg gaacctcagg acccgcccat ttctcggcag 5460
tactgtgaat tttgaagtta aactaaattt tggtaccata ccaactggaa tttaggcttt 5520
aaaaataatg tttcaaggcc aggtgtggtg attcatgcct gaaatcccac tactttggga 5580
ggctgaggct ggagaattgc ttgaggctag tgagctgtga ctcccactgc actccagctc 5640
ggggaacaga gcgagacctt gtctctaaaa ataatagtaa taaaataaaa ataacgtttt 5700
atgactattt attgcaaggt cagagttaca gattgttata aattgttgag aaatttttgt 5760
gattagaata tgaaggaaaa agctttgttg gtaaaagtga catgttaagg ggctatgaag 5820
taaatatgct gcagttaatt atgctaagtt aaaatacagt ttagttattt gctttaaaat 5880
aaactcttct ttttttcttt aaagtatact atctcaaaac tcattatgtt gtcagagccc 5940
tagagctggc tagtgtaaca ctgactatga gtaggtgggc ccacacttga gttgaggtga 6000
tttcatggtg tctttccagg ctcttgatag ggtgtcactg catgcaagcc atgaatctgt 6060
tttgagaatc ctctccattt tcccaaataa aaacctatca caacagtgac tatatcactc 6120
agcattggat ctaaatataa aagtggtgct ttcagtgttt ttggcagata gtgttccata 6180
agctttccat cagaagggat tttagacacc ttagaggtcc gtgctacatc gtcacagttc 6240
ctccgaataa ccttaggtgg tagtgttact tgcctttgac acctctgcat atgttttaat 6300
gactagatcc aaactgtgtt gttcttaaat caaaaattgg ataatttgta atatttatgt 6360
gttaatcaca cagtatgctc tctgaagttc tcttaagcct tcagtttata ctcttaattt 6420
aattttcttt ctgagctgga gaactggctt tgcactttgg ttacacagaa cattggtttc 6480
caattcagtt taactgaaat ttgctgctga tatgttgagt ttgttcttta aaaaatagct 6540
catatatctc atctttcctc ctgtcttaga agaacagacc taactagtga atgtattaat 6600
gaaaatgcat ctatttcaga gctgacatga agagtttagt ttttttactt tataaactgt 6660
gaatatgagt atgccagctg catacgatgt aactaatcat atttaaatat atttcacttt 6720
ctctttgact ttagaccttt tgaagtctgt ataaacttgt tttgaaatat agtctctgct 6780
tacgaatgtc ataacaaaat aattttttgc atgataaaaa attactttga ttacaaaagg 6840
catattcttt catggtttct gcaatgagag gaagtgtaat gattatttta atatttctat 6900
taaatatgtt taactgta 6918
<210>48
<211>6773
<212>DNA
<213>人
<400>48
cggccccaga aaacccgagc gagtaggggg cggcgcgcag gagggaggag aactgggggc 60
gcgggaggct ggtgggtgtc gggggtggag atgtagaaga tgtgacgccg cggcccggcg 120
ggtgccagat tagcggacgc gctgcccgcg gttgcaacgg gatcccgggc gctgcagctt 180
gggaggcggc tctccccagg cggcgtccgc ggagacaccc atccgtgaac cccaggtccc 240
gggccgccgg ctcgccgcgc accaggggcc ggcggacaga agagcggccg agcggctcga 300
ggctggggga ccgcgggcgc ggccgcgcgc tgccgggcgg gaggctgggg ggccggggcc 360
ggggccgtgc cccggagcgg gtcggaggcc ggggccgggg ccgggggacg gcggctcccc 420
gcgcggctcc agcggctcgg ggatcccggc cgggccccgc agggaccatg gcagccggga 480
gcatcaccac gctgcccgcc ttgcccgagg atggcggcag cggcgccttc ccgcccggcc 540
acttcaagga ccccaagcgg ctgtactgca aaaacggggg cttcttcctg cgcatccacc 600
ccgacggccg agttgacggg gtccgggaga agagcgaccc tcacatcaag ctacaacttc 660
aagcagaaga gagaggagtt gtgtctatca aaggagtgtg tgctaaccgt tacctggcta 720
tgaaggaaga tggaagatta ctggcttcta aatgtgttac ggatgagtgt ttcttttttg 780
aacgattgga atctaataac tacaatactt accggtcaag gaaatacacc agttggtatg 840
tggcactgaa acgaactggg cagtataaac ttggatccaa aacaggacct gggcagaaag 900
ctatactttt tcttccaatg tctgctaaga gctgatttta atggccacat ctaatctcat 960
ttcacatgaa agaagaagta tattttagaa atttgttaat gagagtaaaa gaaaataaat 1020
gtgtatagct cagtttggat aattggtcaa acaatttttt atccagtagt aaaatatgta 1080
accattgtcc cagtaaagaa aaataacaaa agttgtaaaa tgtatattct cccttttata 1140
ttgcatctgc tgttacccag tgaagcttac ctagagcaat gatctttttc acgcatttgc 1200
tttattcgaa aagaggcttt taaaatgtgc atgtttagaa acaaaatttc ttcatggaaa 1260
tcatatacat tagaaaatca cagtcagatg tttaatcaat ccaaaatgtc cactatttct 1320
tatgtcattc gttagtctac atgtttctaa acatataaat gtgaatttaa tcaattcctt 1380
tcatagtttt ataattctct ggcagttcct tatgatagag tttataaaac agtcctgtgt 1440
aaactgctgg aagttcttcc acagtcaggt caattttgtc aaacccttct ctgtacccat 1500
acagcagcag cctagcaact ctgctggtga tgggagttgt attttcagtc ttcgccaggt 1560
cattgagatc catccactca catcttaagc attcttcctg gcaaaaattt atggtgaatg 1620
aatatggctt taggcggcag atgatataca tatctgactt cccaaaagct ccaggatttg 1680
tgtgctgttg ccgaatactc aggacggacc tgaattctga ttttatacca gtctcttcaa 1740
aaacttctcg aaccgctgtg tctcctacgt aaaaaaagag atgtacaaat caataataat 1800
tacactttta gaaactgtat catcaaagat tttcagttaa agtagcatta tgtaaaggct 1860
caaaacatta ccctaacaaa gtaaagtttt caatacaaat tctttgcctt gtggatatca 1920
agaaatccca aaatattttc ttaccactgt aaattcaaga agcttttgaa atgctgaata 1980
tttctttggc tgctacttgg aggcttatct acctgtacat ttttggggtc agctcttttt 2040
aacttcttgc tgctcttttt cccaaaaggt aaaaatatag attgaaaagt taaaacattt 2100
tgcatggctg cagttccttt gtttcttgag ataagattcc aaagaactta gattcatttc 2160
ttcaacaccg aaatgctgga ggtgtttgat cagttttcaa gaaacttgga atataaataa 2220
ttttataatt caacaaaggt tttcacattt tataaggttg atttttcaat taaatgcaaa 2280
tttgtgtggc aggattttta ttgccattaa catatttttg tggctgcttt ttctacacat 2340
ccagatggtc cctctaactg ggctttctct aattttgtga tgttctgtca ttgtctccca 2400
aagtatttag gagaagccct ttaaaaagct gccttcctct accactttgc tggaaagctt 2460
cacaattgtc acagacaaag atttttgttc caatactcgt tttgcctcta tttttcttgt 2520
ttgtcaaata gtaaatgata tttgcccttg cagtaattct actggtgaaa aacatgcaaa 2580
gaagaggaag tcacagaaac atgtctcaat tcccatgtgc tgtgactgta gactgtctta 2640
ccatagactg tcttacccat cccctggata tgctcttgtt ttttccctct aatagctatg 2700
gaaagatgca tagaaagagt ataatgtttt aaaacataag gcattcatct gccatttttc 2760
aattacatgc tgacttccct tacaattgag atttgcccat aggttaaaca tggttagaaa 2820
caactgaaag cataaaagaa aaatctaggc cgggtgcagt ggctcatgcc tatattccct 2880
gcactttggg aggccaaagc aggaggatcg cttgagccca ggagttcaag accaacctgg 2940
tgaaaccccg tctctacaaa aaaacacaaa aaatagccag gcatggtggc gtgtacatgt 3000
ggtctcagat acttgggagg ctgaggtggg agggttgatc acttgaggct gagaggtcaa 3060
ggttgcagtg agccataatc gtgccactgc agtccagcct aggcaacaga gtgagacttt 3120
gtctcaaaaa aagagaaatt ttccttaata agaaaagtaa tttttactct gatgtgcaat 3180
acatttgtta ttaaatttat tatttaagat ggtagcacta gtcttaaatt gtataaaata 3240
tcccctaaca tgtttaaatg tccattttta ttcattatgc tttgaaaaat aattatgggg 3300
aaatacatgt ttgttattaa atttattatt aaagatagta gcactagtct taaatttgat 3360
ataacatctc ctaacttgtt taaatgtcca tttttattct ttatgcttga aaataaatta 3420
tggggatcct atttagctct tagtaccact aatcaaaagt tcggcatgta gctcatgatc 3480
tatgctgttt ctatgtcgtg gaagcaccgg atgggggtag tgagcaaatc tgccctgctc 3540
agcagtcacc atagcagctg actgaaaatc agcactgcct gagtagtttt gatcagttta 3600
cttgaatca ctaactgact gaaaattgaa tgggcaaata agtgcttttg tctccagagt 3660
atgcgggaga cccttccacc tcaagatgga tatttcttcc ccaaggattt caagatgaat 3720
tgaaattttt aatcaagata gtgtgcttta ttctgttgta ttttttatta ttttaatata 3780
ctgtaagcca aactgaaata acatttgctg ttttataggt ttgaagaaca taggaaaaac 3840
taagaggttt tgtttttatt tttgctgatg aagagatatg tttaaatatg ttgtattgtt 3900
ttgtttagtt acaggacaat aatgaaatgg agtttatatt tgttatttct attttgttat 3960
atttaataat agaattagat tgaaataaaa tataatggga aataatctgc agaatgtggg 4020
tttcctggtg tttcctctga ctctagtgca ctgatgatct ctgataaggc tcagctgctt 4080
tatagttctc tggctaatgc agcagatact cttcctgcca gtggtaatac gattttttaa 4140
gaaggcagtt tgtcaatttt aatcttgtgg atacctttat actcttaggg tattatttta 4200
tacaaaagcc ttgaggattg cattctattt tctatatgac cctcttgata tttaaaaaac 4260
actatggata acaattcttc atttacctag tattatgaaa gaatgaagga gttcaaacaa 4320
atgtgtttcc cagttaacta gggtttactg tttgagccaa tataaatgtt taactgtttg 4380
tgatggcagt attcctaaag tacattgcat gttttcctaa atacagagtt taaataattt 4440
cagtaattct tagatgattc agcttcatca ttaagaatat cttttgtttt atgttgagtt 4500
agaaatgcct tcatatagac atagtctttc agacctctac tgtcagtttt catttctagc 4560
tgctttcagg gttttatgaa ttttcaggca aagctttaat ttatactaag cttaggaagt 4620
atggctaatg ccaacggcag tttttttctt cttaattcca catgactgag gcatatatga 4680
tctctgggta ggtgagttgt tgtgacaacc acaagcactt tttttttttt taaagaaaaa 4740
aaggtagtga atttttaatc atctggactt taagaaggat tctggagtat acttaggcct 4800
gaaattatat atatttggct tggaaatgtg tttttcttca attacatcta caagtaagta 4860
cagctgaaat tcagaggacc cataagagtt cacatgaaaa aaatcaattc atttgaaaag 4920
gcaagatgca ggagagagga agccttgcaa acctgcagac tgctttttgc ccaatataga 4980
ttgggtaagg ctgcaaaaca taagcttaat tagctcacat gctctgctct cacgtggcac 5040
cagtggatag tgtgagagaa ttaggctgta gaacaaatgg ccttctcttt cagcattcac 5100
accactacaa aatcatcttt tatatcaaca gaagaataag cataaactaa gcaaaaggtc 5160
aataagtacc tgaaaccaag attggctaga gatatatctt aatgcaatcc attttctgat 5220
ggattgttac gagttggcta tataatgtat gtatggtatt ttgatttgtg taaaagtttt 5280
aaaaatcaag ctttaagtac atggacattt ttaaataaaa tatttaaaga caatttagaa 5340
aattgcctta atatcattgt tggctaaata gaatagggga catgcatatt aaggaaaagg 5400
tcatggagaa ataatattgg tatcaaacaa atacattgat ttgtcatgat acacattgaa 5460
tttgatccaa tagtttaagg aataggtagg aaaatttggt ttctattttt cgatttcctg 5520
taaatcagtg acataaataa ttcttagctt attttatatt tccttgtctt aaatactgag 5580
ctcagtaagt tgtgttaggg gattatttct cagttgagac tttcttatat gacattttac 5640
tatgttttga cttcctgact attaaaaata aatagtagaa acaattttca taaagtgaag 5700
aattatataa tcactgcttt ataactgact ttattatatt tatttcaaag ttcatttaaa 5760
ggctactatt catcctctgt gatggaatgg tcaggaattt gttttctcat agtttaattc 5820
caacaacaat attagtcgta tccaaaataa cctttaatgc taaactttac tgatgtatat 5880
ccaaagcttc tccttttcag acagattaat ccagaagcag tcataaacag aagaataggt 5940
ggtatgttcc taatgatatt atttctacta atggaataaa ctgtaatatt agaaattatg 6000
ctgctaatta tatcagctct gaggtaattt ctgaaatgtt cagactcagt cggaacaaat 6060
tggaaaattt aaatttttat tcttagctat aaagcaagaa agtaaacaca ttaatttcct 6120
caacattttt aagccaatta aaaatataaa agatacacac caatatcttc ttcaggctct 6180
gacaggcctc ctggaaactt ccacatattt ttcaactgca gtataaagtc agaaaataaa 6240
gttaacataa ctttcactaa cacacacata tgtagatttc acaaaatcca cctataattg 6300
gtcaaagtgg ttgagaatat attttttagt aattgcatgc aaaatttttc tagcttccat 6360
cctttctccc tcgtttcttc tttttttggg ggagctggta actgatgaaa tcttttccca 6420
ccttttctct tcaggaaata taagtggttt tgtttggtta acgtgataca ttctgtatga 6480
atgaaacatt ggagggaaac atctactgaa tttctgtaat ttaaaatatt ttgctgctag 6540
ttaactatga acagatagaa gaatcttaca gatgctgcta taaataagta gaaaatataa 6600
atttcatcac taaaatatgc tattttaaaa tctatttcct atattgtatt tctaatcaga 6660
tgtattactc ttattatttc tattgtatgt gttaatgatt ttatgtaaaa atgtaattgc 6720
ttttcatgag tagtatgaat aaaattgatt agtttgtgtt ttcttgtctc ccg 6773
<210>49
<211>3537
<212>DNA
<213>人
<400>49
cagaccccag ttcgccgact aagcagaaga aagatcaaaa accggaaaag aggagaagag 60
caaacaggca ctttgaggaa caatcccctt taactccaag ccgacagcgg tctaggaatt 120
caagttcagt gcctaccgaa gacaaaggcg ccccgaggga gtggcggtgc gaccccaggg 180
cgtgggcccg gccgcggagc ccacactgcc cggctgaccc ggtggtctcg gaccatgtct 240
cccgccccaa gacccccccg ttgtctcctg ctccccctgc tcacgctcgg caccgcgctc 300
gcctccctcg gctcggccca aagcagcagc ttcagccccg aagcctggct acagcaatat 360
ggctacctgc ctcccgggga cctacgtacc cacacacagc gctcacccca gtcactctca 420
gcggccatcg ctgccatgca gaagttttac ggcttgcaag taacaggcaa agctgatgca 480
gacaccatga aggccatgag gcgcccccga tgtggtgttc cagacaagtt tggggctgag 540
atcaaggcca atgttcgaag gaagcgctac gccatccagg gtctcaaatg gcaacataat 600
gaaatcactt tctgcatcca gaattacacc cccaaggtgg gcgagtatgc cacatacgag 660
gccattcgca aggcgttccg cgtgtgggag agtgccacac cactgcgctt ccgcgaggtg 720
ccctatgcct acatccgtga gggccatgag aagcaggccg acatcatgat cttctttgcc 780
gagggcttcc atggcgacag cacgcccttc gatggtgagg gcggcttcct ggcccatgcc 840
tacttcccag gccccaacat tggaggagac acccactttg actctgccga gccttggact 900
gtcaggaatg aggatctgaa tggaaatgac atcttcctgg tggctgtgca cgagctgggc 960
catgccctgg ggctcgagca ttccagtgac ccctcggcca tcatggcacc cttttaccag 1020
tggatggaca cggagaattt tgtgctgccc gatgatgacc gccggggcat ccagcaactt 1080
tatgggggtg agtcagggtt ccccaccaag atgccccctc aacccaggac tacctcccgg 1140
ccttctgttc ctgataaacc caaaaacccc acctatgggc ccaacatctg tgacgggaac 1200
tttgacaccg tggccatgct ccgaggggag atgtttgtct tcaaggagcg ctggttctgg 1260
cgggtgagga ataaccaagt gatggatgga tacccaatgc ccattggcca gttctggcgg 1320
ggcctgcctg cgtccatcaa cactgcctac gagaggaagg atggcaaatt cgtcttcttc 1380
aaaggagaca agcattgggt gtttgatgag gcgtccctgg aacctggcta ccccaagcac 1440
attaaggagc tgggccgagg gctgcctacc gacaagattg atgctgctct cttctggatg 1500
cccaatggaa agacctactt cttccgtgga aacaagtact accgtttcaa cgaagagctc 1560
agggcagtgg atagcgagta ccccaagaac atcaaagtct gggaagggat ccctgagtct 1620
cccagagggt cattcatggg cagcgatgaa gtcttcactt acttctacaa ggggaacaaa 1680
tactggaaat tcaacaacca gaagctgaag gtagaaccgg gctaccccaa gtcagccctg 1740
agggactgga tgggctgccc atcgggaggc cggccggatg aggggactga ggaggagacg 1800
gaggtgatca tcattgaggt ggacgaggag ggcggcgggg cggtgagcgc ggctgccgtg 1860
gtgctgcccg tgctgctgct gctcctggtg ctggcggtgg gccttgcagt cttcttcttc 1920
agacgccatg ggacccccag gcgactgctc tactgccagc gttccctgct ggacaaggtc 1980
tgacgcccac cgccggcccg cccactccta ccacaaggac tttgcctctg aaggccagtg 2040
gcagcaggtg gtggtgggtg ggctgctccc atcgtcccga gccccctccc cgcagcctcc 2100
ttgcttctct ctgtcccctg gctggcctcc ttcaccctga ccgcctccct ccctcctgcc 2160
ccggcattgc atcttcccta gataggtccc ctgagggctg agtgggaggg cggccctttc 2220
cagcctctgc ccctcagggg aaccctgtag ctttgtgtct gtccagcccc atctgaatgt 2280
gttgggggct ctgcacttga aggcaggacc ctcagacctc gctggtaaag gtcaaatggg 2340
gtcatctgct ccttttccat cccctgacat accttaacct ctgaactctg acctcaggag 2400
gctctgggca ctccagccct gaaagcccca ggtgtaccca attggcagcc tctcactact 2460
ctttctggct aaaaggaatc taatcttgtt gagggtagag accctgagac agtgtgaggg 2520
ggtggggact gccaagccac cctaagacct tgggaggaaa actcagagag ggtcttcgtt 2580
gctcagtcag tcaagttcct cggagatctg cctctgcctc acctacccca gggaacttcc 2640
aaggaaggag cctgagccac tggggactaa gtgggcagaa gaaacccttg gcagccctgt 2700
gcctctcgaa tgttagcctt ggatggggct ttcacagtta gaagagctga aaccaggggt 2760
gcagctgtca ggtagggtgg ggccggtggg agaggcccgg gtcagagccc tgggggtgag 2820
cctgaaggcc acagagaaag aaccttgccc aaactcaggc agctggggct gaggcccaaa 2880
ggcagaacag ccagaggggg caggagggga ccaaaaagga aaatgaggac gtgcagcagc 2940
attggaaggc tggggccggg caggccaggc caagccaagc agggggccac agggtgggct 3000
gtggagctct caggaagggc cctgaggaag gcacacttgc tcctgttggt ccctgtcctt 3060
gctgcccagg cagcgtggag gggaagggta gggcagccag agaaaggagc agagaaggca 3120
cacaaacgag gaatgagggg cttcacgaga ggccacaggg cctggctggc cacgctgtcc 3180
cggcctgctc accatctcag tgaggggcag gagctggggc tcgcttaggc tgggtccacg 3240
cttccctggt gccagcaccc ctcaagcctg tctcaccagt ggcctgccct ctcgctcccc 3300
cacccagccc acccattgaa gtctccttgg gccaccaaag gtggtggcca tggtaccggg 3360
gacttgggag agtgagaccc agtggaggga gcaagaggag agggatgtcg ggggggtggg 3420
gcacggggta ggggaaatgg ggtgaacggt gctggcagtt cggctagatt tctgtcttgt 3480
ttgttttttt gttttgttta atgtatattt ttattataat tattatatat gaattcc 3537
<210>50
<211>4624
<212>DNA
<213>人
<400>50
ggaggaggtg gaggaggagg gctgcttgag gaagtataag aatgaagttg tgaagctgag 60
attcccctcc attgggaccg gagaaaccag gggagccccc cgggcagccg cgcgcccctt 120
cccacggggc cctttactgc gccgcgcgcc cggcccccac ccctcgcagc accccgcgcc 180
ccgcgccctc ccagccgggt ccagccggag ccatggggcc ggagccgcag tgagcaccat 240
ggagctggcg gccttgtgcc gctgggggct cctcctcgcc ctcttgcccc ccggagccgc 300
gagcacccaa gtgtgcaccg gcacagacat gaagctgcgg ctccctgcca gtcccgagac 360
ccacctggac atgctccgcc acctctacca gggctgccag gtggtgcagg gaaacctgga 420
actcacctac ctgcccacca atgccagcct gtccttcctg caggatatcc aggaggtgca 480
gggctacgtg ctcatcgctc acaaccaagt gaggcaggtc ccactgcaga ggctgcggat 540
tgtgcgaggc acccagctct ttgaggacaa ctatgccctg gccgtgctag acaatggaga 600
cccgctgaac aataccaccc ctgtcacagg ggcctcccca ggaggcctgc gggagctgca 660
gcttcgaagc ctcacagaga tcttgaaagg aggggtcttg atccagcgga acccccagct 720
ctgctaccag gacacgattt tgtggaagga catcttccac aagaacaacc agctggctct 780
cacactgata gacaccaacc gctctcgggc ctgccacccc tgttctccga tgtgtaaggg 840
ctcccgctgc tggggagaga gttctgagga ttgtcagagc ctgacgcgca ctgtctgtgc 900
cggtggctgt gcccgctgca aggggccact gcccactgac tgctgccatg agcagtgtgc 960
tgccggctgc acgggcccca agcactctga ctgcctggcc tgcctccact tcaaccacag 1020
tggcatctgt gagctgcact gcccagccct ggtcacctac aacacagaca cgtttgagtc 1080
tatgcccaat cccgagggcc ggtatacatt cggcgccagc tgtgtgactg cctgtcccta 1140
caactacctt tctacggacg tgggatcctg caccctcgtc tgccccctgc acaaccaaga 1200
ggtgacagca gaggatggaa cacagcggtg tgagaagtgc agcaagccct gtgcccgagt 1260
gtgctatggt ctgggcatgg agcacttgcg agaggtgagg gcagttacca gtgccaatat 1320
ccaggagttt gctggctgca agaagatctt tgggagcctg gcatttctgc cggagagctt 1380
tgatggggac ccagcctcca acactgcccc gctccagcca gagcagctcc aagtgtttga 1440
gactctggaa gagatcacag gttacctata catctcagca tggccggaca gcctgcctga 1500
cctcagcgtc ttccagaacc tgcaagtaat ccggggacga attctgcaca atggcgccta 1560
ctcgctgacc ctgcaagggc tgggcatcag ctggctgggg ctgcgctcac tgagggaact 1620
gggcagtgga ctggccctca tccaccataa cacccacctc tgcttcgtgc acacggtgcc 1680
ctgggaccag ctctttcgga acccgcacca agctctgctc cacactgcca accggccaga 1740
ggacgagtgt gtgggcgagg gcctggcctg ccaccagctg tgcgcccgag ggcactgctg 1800
gggtccaggg cccacccagt gtgtcaactg cagccagttc cttcggggcc aggagtgcgt 1860
ggaggaatgc cgagtactgc aggggctccc cagggagtat gtgaatgcca ggcactgttt 1920
gccgtgccac cctgagtgtc agccccagaa tggctcagtg acctgttttg gaccggaggc 1980
tgaccagtgt gtggcctgtg cccactataa ggaccctccc ttctgcgtgg cccgctgccc 2040
cagcggtgtg aaacctgacc tctcctacat gcccatctgg aagtttccag atgaggaggg 2100
cgcatgccag ccttgcccca tcaactgcac ccactcctgt gtggacctgg atgacaaggg 2160
ctgccccgcc gagcagagag ccagccctct gacgtccatc atctctgcgg tggttggcat 2220
tctgctggtc gtggtcttgg gggtggtctt tgggatcctc atcaagcgac ggcagcagaa 2280
gatccggaag tacacgatgc ggagactgct gcaggaaacg gagctggtgg agccgctgac 2340
acctagcgga gcgatgccca accaggcgca gatgcggatc ctgaaagaga cggagctgag 2400
gaaggtgaag gtgcttggat ctggcgcttt tggcacagtc tacaagggca tctggatccc 2460
tgatggggag aatgtgaaaa ttccagtggc catcaaagtg ttgagggaaa acacatcccc 2520
caaagccaac aaagaaatct tagacgaagc atacgtgatg gctggtgtgg gctccccata 2580
tgtctcccgc cttctgggca tctgcctgac atccacggtg cagctggtga cacagcttat 2640
gccctatggc tgcctcttag accatgtccg ggaaaaccgc ggacgcctgg gctcccagga 2700
cctgctgaac tggtgtatgc agattgccaa ggggatgagc tacctggagg atgtgcggct 2760
cgtacacagg gacttggccg ctcggaacgt gctggtcaag agtcccaacc atgtcaaaat 2820
tacagacttc gggctggctc ggctgctgga cattgacgag acagagtacc atgcagatgg 2880
gggcaaggtg cccatcaagt ggatggcgct ggagtccatt ctccgccggc ggttcaccca 2940
ccagagtgat gtgtggagtt atggtgtgac tgtgtgggag ctgatgactt ttggggccaa 3000
accttacgat gggatcccag cccgggagat ccctgacctg ctggaaaagg gggagcggct 3060
gccccagccc cccatctgca ccattgatgt ctacatgatc atggtcaaat gttggatgat 3120
tgactctgaa tgtcggccaa gattccggga gttggtgtct gaattctccc gcatggccag 3180
ggacccccag cgctttgtgg tcatccagaa tgaggacttg ggcccagcca gtcccttgga 3240
cagcaccttc taccgctcac tgctggagga cgatgacatg ggggacctgg tggatgctga 3300
ggagtatctg gtaccccagc agggcttctt ctgtccagac cctgccccgg gcgctggggg 3360
catggtccac cacaggcacc gcagctcatc taccaggagt ggcggtgggg acctgacact 3420
agggctggag ccctctgaag aggaggcccc caggtctcca ctggcaccct ccgaaggggc 3480
tggctccgat gtatttgatg gtgacctggg aatgggggca gccaaggggc tgcaaagcct 3540
ccccacacat gaccccagcc ctctacagcg gtacagtgag gaccccacag tacccctgcc 3600
ctctgagact gatggctacg ttgcccccct gacctgcagc ccccagcctg aatatgtgaa 3660
ccagccagat gttcggcccc agcccccttc gccccgagag ggccctctgc ctgctgcccg 3720
acctgctggt gccactctgg aaaggcccaa gactctctcc ccagggaaga atggggtcgt 3780
caaagacgtt tttgcctttg ggggtgccgt ggagaacccc gagtacttga caccccaggg 3840
aggagctgcc cctcagcccc accctcctcc tgccttcagc ccagccttcg acaacctcta 3900
ttactgggac caggacccac cagagcgggg ggctccaccc agcaccttca aagggacacc 3960
tacggcagag aacccagagt acctgggtct ggacgtgcca gtgtgaacca gaaggccaag 4020
tccgcagaag ccctgatgtg tcctcaggga gcagggaagg cctgacttct gctggcatca 4080
agaggtggga gggccctccg accacttcca ggggaacctg ccatgccagg aacctgtcct 4140
aaggaacctt ccttcctgct tgagttccca gatggctgga aggggtccag cctcgttgga 4200
agaggaacag cactggggag tctttgtgga ttctgaggcc ctgcccaatg agactctagg 4260
gtccagtgga tgccacagcc cagcttggcc ctttccttcc agatcctggg tactgaaagc 4320
cttagggaag ctggcctgag aggggaagcg gccctaaggg agtgtctaag aacaaaagcg 4380
acccattcag agactgtccc tgaaacctag tactgccccc catgaggaag gaacagcaat 4440
ggtgtcagta tccaggcttt gtacagagtg cttttctgtt tagtttttac tttttttgtt 4500
ttgttttttt aaagatgaaa taaagaccca gggggagaat gggtgttgta tggggaggca 4560
agtgtggggg gtccttctcc acacccactt tgtccatttg caaatatatt ttggaaaaca 4620
gcta 4624
<210>51
<211>69
<212>DNA
<213>人
<400>51
gagtgtcttt ctttgcaggt ttctgtagcc ggaagatctc cgttccgctc ccagcggctc 60
cagtgtaaa 69
<210>52
<211>70
<212>DNA
<213>人
<400>52
aagagaccat ctgcccgagt agccgcaaat gtgcttcatc taagcctctg gggtgaacat 60
attctagccc 70
<210>53
<211>69
<212>DNA
<213>人
<400>53
accgaagaaa ctgtggctac ccgggcatca gccccgagga atgcgcctct cggaagtgct 60
gcttctcca 69
<210>54
<211>69
<212>DNA
<213>人
<400>54
acacagccga gcagcatttc cgttgaagga cttgcatccc cattgcgggc agtgctggac 60
gtgtcccgg 69
<210>55
<211>70
<212>DNA
<213>人
<400>55
acaaacgggc tcatcataat gcactggaac gaaaacgtag ggaccacatc aaagacagct 60
ttcacagttt 70
<210>56
<211>69
<212>DNA
<213>人
<400>56
tccagcccat ccagcaatcg ccccctttct gccctggggg cccaggatgt agatattgta 60
caaaggttt 69
<210>57
<211>70
<212>DNA
<213>人
<400>57
agtatggctg cagtcctccg gttgcatact ggactcttca aaaactgttt tgggtagctg 60
ccacttgaac 70
<210>58
<211>69
<212>DNA
<213>人
<400>58
ccggagtcac cccgatgatt actcttttca gacacagcgg tttttgtttc caagaagcca 60
aaattgttt 69
<210>59
<211>69
<212>DNA
<213>人
<400>59
tctccacaat gcaagctaca gagctgggga agttgccggc tggaggagtt ctctaccctc 60
caccttcct 69
<210>60
<211>69
<212>DNA
<213>人
<400>60
gctgggcttc attagtgagg ctgaccagag ccggttgact tctctgctag aagagacctt 60
gaacaagtt 69
<210>61
<211>69
<212>DNA
<213>人
<400>61
ggcgacagga acgtgtctag gcgaacgact aaagcacctg gaaaggctga tccggagttc 60
aagggaaga 69
<210>62
<211>69
<212>DNA
<213>人
<400>62
cattcgggcc atttccgtgg tttctcatga gctgtgttca cagacctcag cagggcatcg 60
catggaccg 69
<210>63
<211>69
<212>DNA
<213>人
<400>63
agatagtgct ctgtgcctaa ggtgaagcca cactagggtg aagcctcact tccctgtttg 60
agcaatgca 69
<210>64
<211>70
<212>DNA
<213>人
<400>64
tggggaggga tggcccagcc tgtaagatac tgtatatgcg ctgctgtaga taccggaatg 60
aattttctgt 70
<210>65
<211>69
<212>DNA
<213>人
<400>65
tcacattcag gcccctgttc ttcaagctgt ttgattgggc taaaacagaa gatgccccaa 60
aggacaggt 69
<210>66
<211>69
<212>DNA
<213>人
<400>66
attatgatta ctatatccga ggagcaacaa ccactttctc tgcagtggaa agggatcgcc 60
agtggaagt 69
<210>67
<211>69
<212>DNA
<213>人
<400>67
caccaggagt accgttagct ttccccttct tctggcccat ttgactcatc agcacaatag 60
ggtcaccac 69
<210>68
<211>69
<212>DNA
<213>人
<400>68
acccccagca cagggggatt ctgagcagtg cctcttgtct gagggacata tcagtgacct 60
cgacgttgc 69
<210>69
<211>69
<212>DNA
<213>人
<400>69
tctgtgatgt aggagtctct ctaccactgg atgaaaatat gactgtgact gaccctgagg 60
cttgttaca 69
<210>70
<211>69
<212>DNA
<213>人
<400>70
ctccacagcg gttcttcaca ggatcccagc aatgaactgt tctagggaaa gtggcttcct 60
gcccaaact 69
<210>71
<211>69
<212>DNA
<213>人
<400>71
atgggaagga agggaccctt acccccggct cttctcctga cctgccaata aaaatttatg 60
gtccaaggg 69
<210>72
<211>69
<212>DNA
<213>人
<400>72
cttggcaact gctagagcag ggagggggga gggcagggga ttacctaatt agagtgggtt 60
agcttagat 69
<210>73
<211>69
<212>DNA
<213>人
<400>73
gtcctcattc cctgcccttc ctttggttgc catatggaat ggccatggaa tgcacgaagt 60
cacaatgca 69
<210>74
<211>69
<212>DNA
<213>人
<400>74
tctcttgaga ctcgttactg ggcatcagta gaagaatata ttcccaaatg ggaacagttt 60
cttttagga 69
<210>75
<211>69
<212>DNA
<213>人
<400>75
tggtatccag aatggaattt tgctacatgg ggtctgggtg ggggcaaaga gacccagtca 60
attacatgt 69
<210>76
<211>69
<212>DNA
<213>人
<400>76
ctattctgga ggcaccaagg aactagcaga gatgatgaat gcatcatcaa gcacgaccac 60
attgtttcc 69
<210>77
<211>69
<212>DNA
<213>人
<400>77
tcaggtgggc cttgagttat attttaactc agctgctcag ttcccagggc acatttctgg 60
atcagaacc 69
<210>78
<211>70
<212>DNA
<213>人
<400>78
gggagataca gccatccacc ttcagatgtg tctacgtgcg ctctgccatt caactcggaa 60
actataagta 70
<210>79
<211>69
<212>DNA
<213>人
<400>79
aattaaagtt atagacaaga tgggagggcc agaagagttt atccagagat tcctccctcg 60
ggagctcca 69
<210>80
<211>70
<212>DNA
<213>人
<400>80
cagctttgct ttgcaaagat tgatgacaga ctggttcctc agaggcctag gctacccgtc 60
accccttttt 70
<210>81
<211>70
<212>DNA
<213>人
cctcctgggg agtgtcattt ttgtctacag cttcattgac ttccacgtgt tccaccgcaa 60
agatagccgc 70
<210>82
<211>60
<212>DNA
<213>人
<400>82
gaaggagggg ctgggccagg gccagtcgct ggaacagctg gaagctctgg tgcaaaccaa 60
<210>83
<211>69
<212>DNA
<213>人
<400>83
ggtgggggaa cactgagaaa gaggcaggga cctaaaggga ctacctctgt gccttgccac 60
attaaattg 69
<210>84
<211>69
<212>DNA
<213>人
<400>84
ggcaagatct atcggcaggg aaacctgttt gacttcttac gcttgacgga atggcgtggc 60
ccccgcgtg 69
<210>85
<211>69
<212>DNA
<213>人
<400>85
aggctaggtg ggttgaaagc caaggagtca ctgagaccaa ggctttctct actgattccg 60
cagctcaga 69
<210>86
<211>69
<212>DNA
<213>人
<400>86
tgactagcga gggacctccg ctgcatctca gcaaagcccc tcccagggtt tgatcgattg 60
agcaggaca 69
<210>87
<211>69
<212>DNA
<213>人
<400>87
tcctctgtca tactgtatct ggaatgcttt gtaatacttg catgcttctt agaccagaac 60
atgtaggtc 69
<210>88
<211>69
<212>DNA
<213>人
<400>88
agctcctcgg agggaacaga gcggctgtgt atgcagcctg caggtttcca tacactgaag 60
cttttacct 69
<210>89
<211>69
<212>DNA
<213>人
<400>89
gtaggctgag ggctgcacct cccacggtgg tcaccatgcc aatgaaggaa gttcagtctt 60
gtctttgat 69
<210>90
<211>70
<212>DNA
<213>人
<400>90
acctcgaggc acttacttgc aagtcagggg caagagacaa taattaaaac caaagtcaga 60
atcccagcac 70
<210>91
<211>69
<212>DNA
<213>人
<400>91
attcctgcca ccactgggca aacagaagaa tttttctgtc tttggagagt attttagaaa 60
ctccaatga 69
<210>92
<211>70
<212>DNA
<213>人
<400>92
gagaaccaga agacgatgag gctcctgcaa aagctcagta ctacacagtg acagatgagc 60
atcacagatc 70
<210>93
<211>69
<212>DNA
<213>人
<400>93
ttctcccagg atggtgaagg gggacctggt acccagtgat ccccacccca ggatcctaaa 60
tcatgactt 69
<210>94
<211>70
<212>DNA
<213>人
<400>94
cagtgtttca aatgccgtga aacatggcat catgctctaa cttcagtata ccaataaaac 60
aatcagcttg 70
<210>95
<211>69
<212>DNA
<213>人
<400>95
tcgattcagt cataggcgaa tctgttctgc ccgaggcttg tggtcaagca aaaattcagc 60
cctgaaatc 69
<210>96
<211>69
<212>DNA
<213>人
<400>96
tgcaattacg tccaccaaag acccgtgttg ggggtactga aggagaggcc ctgggggacc 60
ctctgaagc 69
<210>97
<211>71
<212>DNA
<213>人
<400>97
gggaaaactt gctgcggttg ctcaaggtga ggaataaaat gcttcccgtt cttctggatg 60
ggcatcctat c 71
<210>98
<211>69
<212>DNA
<213>人
<400>98
atataaaaga tacacaccaa tatcttcttc aggctctgac aggcctcctg gaaacttcca 60
catattttt 69
<210>99
<211>70
<212>DNA
<213>人
<400>99
agctcagggc agtggatagc gagtacccca agaacatcaa agtctgggaa gggatccctg 60
agtctcccag 70
<210>100
<211>69
<212>DNA
<213>人
<400>100
gactgtccct gaaacctagt actgcccccc atgaggaagg aacagcaatg gtgtcagtat 60
ccaggcttt 69
<210>101
<211>306
<212>PRT
<213>人
<400>101
Met Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Ala Ala Gly Gly
1 5 10 15
Arg Gly Ser Gly Pro Gly Arg Arg Arg His Leu Val Pro Gly Ala Gly
20 25 30
Gly Glu Ala Gly Glu Gly Ala Pro Gly Gly Ala Gly Asp Tyr Gly Asn
35 40 45
Gly Leu Glu Ser Glu Glu Leu Glu Pro Glu Glu Leu Leu Leu Glu Pro
50 55 60
Glu Pro Glu Pro Glu Pro Glu Glu Glu Pro Pro Arg Pro Arg Ala Pro
65 70 75 80
Pro Gly Ala Pro Gly Pro Gly Pro Gly Ser Gly Ala Pro Gly Ser Gln
85 90 95
Glu Glu Glu Glu Glu Pro Gly Leu Val Glu Gly Asp Pro Gly Asp Gly
100 105 110
Ala Ile Glu Asp Pro Glu Leu Glu Ala Ile Lys Ala Arg Val Arg Glu
115 120 125
Met Glu Glu Glu Ala Glu Lys Leu Lys Glu Leu Gln Asn Glu ValGlu
130 135 140
Lys Gln Met Asn Met Ser Pro Pro Pro Gly Asn Ala Gly Pro Val Ile
145 150 155 160
Met Ser Ile Glu Glu Lys Met Glu Ala Asp Ala Arg Ser Ile Tyr Val
165 170 175
Gly Asn Val Asp Tyr Gly Ala Thr Ala Glu Glu Leu Glu Ala His Phe
180 185 190
His Gly Cys Gly Ser Val Asn Arg ValThr Ile Leu Cys Asp Lys Phe
195 200 205
Ser Gly His Pro Lys Gly Phe Ala Tyr Ile Glu Phe Ser Asp Lys Glu
210 215 220
Ser Val Arg Thr Ser Leu Ala Leu Asp Glu Ser Leu Phe Arg Gly Arg
225 230 235 240
Gln Ile Lys Val Ile Pro Lys Arg Thr Asn Arg Pro Gly Ile Ser Thr
245 250 255
Thr Asp Arg Gly Phe Pro Arg Ala Arg Tyr Arg Ala Arg Thr Thr Asn
260 265 270
Tyr Asn Ser Ser Arg Ser Arg Phe Tyr Ser Gly Phe Asn Ser Arg Pro
275 280 285
Arg Gly Arg Val Tyr Arg Gly Arg Ala Arg Ala Thr Ser Trp Tyr Ser
290 295 300
Pro Tyr
305
<210>102
<211>581
<212>PRT
<213>人
<400>102
Met Ala Val Arg Gln Ala Leu Gly Arg Gly Leu Gln Leu Gly Arg Ala
1 5 10 15
Leu Leu Leu Arg Phe Thr Gly Lys Pro Gly Arg Ala Tyr Gly Leu Gly
20 25 30
Arg Pro Gly Pro Ala Ala Gly Cys Val Arg Gly Glu Arg Pro Gly Trp
35 40 45
Ala Ala Gly Pro Gly Ala Glu Pro Arg Arg Val Gly Leu Gly Leu Pro
50 55 60
Asn Arg Leu Arg Phe Phe Arg Gln Ser Val Ala Gly Leu Ala Ala Arg
65 70 75 80
Leu Gln Arg Gln Phe Val Val Arg Ala Trp Gly Cys Ala Gly Pro Cys
85 90 95
Gly Arg Ala Val Phe Leu Ala Phe Gly Leu Gly Leu Gly Leu Ile Glu
100 105 110
Glu Lys Gln Ala Glu Ser Arg Arg Ala Val Ser Ala Cys Gln Glu Ile
115 120 125
Gln Ala Ile Phe Thr Gln Lys Ser Lys Pro Gly Pro Asp Pro Leu Asp
130 135 140
Thr Arg Arg Leu Gln Gly Phe Arg Leu Glu Glu Tyr Leu Ile Gly Gln
145 150 155 160
Ser Ile Gly Lys Gly Cys Ser Ala Ala Val Tyr Glu Ala Thr Met Pro
165 170 175
Thr Leu Pro Gln Asn Leu Glu Val Thr Lys Ser Thr Gly Leu Leu Pro
180 185 190
Gly Arg Gly Pro Gly Thr Ser Ala Pro Gly Glu Gly Gln Glu Arg Ala
195 200 205
Pro Gly Ala Pro Ala Phe Pro Leu Ala Ile Lys Met Met Trp Asn Ile
210 215 220
Ser Ala Gly Ser Ser Ser Glu Ala Ile Leu Asn Thr Met Ser Gln Glu
225 230 235 240
Leu Val Pro Ala Ser Arg Val Ala Leu Ala Gly Glu Tyr Gly Ala Val
245 250 255
Thr Tyr Arg Lys Ser Lys Arg Gly Pro Lys Gln Leu Ala Pro His Pro
260 265 270
Asn Ile Ile Arg Val Leu Arg Ala Phe Thr Ser Ser Val Pro Leu Leu
275 280 285
Pro Gly Ala Leu Val Asp Tyr Pro Asp Val Leu Pro Ser Arg Leu His
290 295 300
Pro Glu Gly Leu Gly His Gly Arg Thr Leu Phe Leu Val Met Lys Asn
305 310 315 320
Tyr Pro Cys Thr Leu Arg Gln Tyr Leu Cys Val Asn Thr Pro Ser Pro
325 330 335
Arg Leu Ala Ala Met Met Leu Leu Gln Leu Leu Glu Gly Val Asp His
340 345 350
Leu Val Gln Gln Gly Ile Ala His Arg Asp Leu Lys Ser Asp Asn Ile
355 360 365
Leu Val Glu Leu Asp Pro Asp Gly Cys Pro Trp Leu Val Ile Ala Asp
370 375 380
Phe Gly Cys Cys Leu Ala Asp Glu Ser Ile Gly Leu Gln Leu Pro Phe
385 390 395 400
Ser Ser Trp Tyr Val Asp Arg Gly Gly Asn Gly Cys Leu Met Ala Pro
405 410 415
Glu Val Ser Thr Ala Arg Pro Gly Pro Arg Ala Val Ile Asp Tyr Ser
420 425 430
Lys Ala Asp Ala Trp Ala Val Gly Ala Ile Ala Tyr Glu Ile Phe Gly
435 440 445
Leu Val Asn Pro Phe Tyr Gly Gln Gly Lys Ala His Leu Glu Ser Arg
450 455 460
Ser Tyr Gln Glu Ala Gln Leu Pro Ala Leu Pro Glu Ser Val Pro Pro
465 470 475 480
Asp Val Arg Gln Leu Val Arg Ala Leu Leu Gln Arg Glu Ala Ser Lys
485 490 495
Arg Pro Ser Ala Arg Val Ala Ala Asn Val Leu His Leu Ser Leu Trp
500 505 510
Gly Glu His Ile Leu Ala Leu Lys Asn Leu Lys Leu Asp Lys Met Val
515 520 525
Gly Trp Leu Leu Gln Gln Ser Ala Ala Thr Leu Leu Ala Asn Arg Leu
530 535 540
Thr Glu Lys Cys Cys Val Glu Thr Lys Met Lys Met Leu Phe Leu Ala
545 550 555 560
Asn Leu Glu Cys Glu Thr Leu Cys Gln Ala Ala Leu Leu Leu Cys Ser
565 570 575
Trp Arg Ala Ala Leu
580
<210>103
<211>129
<212>PRT
<213>人
<400>103
Met Gly Arg Arg Asp Ala Gln Leu Leu Ala Ala Leu Leu Val Leu Gly
1 5 10 15
Leu Cys Ala Leu Ala Gly Ser Glu Lys Pro Ser Pro Cys Gln Cys Ser
20 25 30
Arg Leu Ser Pro His Asn Arg Thr Asn Cys Gly Phe Pro Gly Ile Thr
35 40 45
Ser Asp Gln Cys Phe Asp Asn Gly Cys Cys Phe Asp Ser Ser Val Thr
50 55 60
Gly Val Pro Trp Cys Phe His Pro Leu Pro Lys Gln Glu Ser Asp Gln
65 70 75 80
Cys Val Met Glu Val Ser Asp Arg Arg Asn Cys Gly Tyr Pro Gly Ile
85 90 95
Ser Pro Glu Glu Cys Ala Ser Arg Lys Cys Cys Phe Ser Asn Phe Ile
100 105 110
Phe Glu Val Pro Trp Cys Phe Phe Pro Lys Ser Val Glu Asp Cys His
115 120 125
Tyr
<210>104
<211>814
<212>PRT
<213>人
<400>104
Met Gln Asp Ala Glu Asn Val Ala Val Pro Glu Ala Ala Glu Glu Arg
1 5 10 15
Ala Glu Pro Gly Gln Gln Gln Pro Ala Ala Glu Pro Pro Pro Ala Glu
20 25 30
Gly Leu Leu Arg Pro Ala Gly Pro Gly Ala Pro Glu Ala Ala Gly Thr
35 40 45
Glu Ala Ser Ser Glu Glu Val Gly Ile Ala Glu Ala Gly Pro Glu Ser
50 55 60
Glu Val Arg Thr Glu Pro Ala Ala Glu Ala Glu Ala Ala Ser Gly Pro
65 70 75 80
Ser Glu Ser Pro Ser Pro Pro Ala Ala Glu Glu Leu Pro Gly Ser His
85 90 95
Ala Glu Pro Pro Val Pro Ala Gln Gly Glu Ala Pro Gly Glu Gln Ala
100 105 110
Arg Asp Glu Arg Ser Asp Ser Arg Ala Gln Ala Val Ser Glu Asp Ala
115 120 125
Gly Gly Asn Glu Gly Arg Ala Ala Glu Ala Glu Pro Arg Ala Leu Glu
130 135 140
Asn Gly Asp Ala Asp Glu Pro Ser Phe Ser Asp Pro Glu Asp Phe Val
145 150 155 160
Asp Asp Val Ser Glu Glu Glu Leu Leu Gly Asp Val Leu Lys Asp Arg
165 170 175
Pro Gln Glu Ala Asp Gly Ile Asp Ser Val Ile ValVal Asp Asn Val
180 185 190
Pro Gln Val Gly Pro Asp Arg Leu Glu Lys Leu Lys Asn Val Ile His
195 200 205
Lys Ile Phe Ser Lys Phe Gly Lys Ile Thr Asn Asp Phe Tyr Pro Glu
210 215 220
Glu Asp Gly Lys Thr Lys Gly Tyr Ile Phe Leu Glu Tyr Ala Ser Pro
225 230 235 240
Ala His Ala Val Asp Ala Val Lys Asn Ala Asp Gly Tyr Lys Leu Asp
245 250 255
Lys Gln His Thr Phe Arg Val Asn Leu Phe Thr Asp Phe Asp Lys Tyr
260 265 270
Met Thr Ile Ser Asp Glu Trp AspIle Pro Glu Lys Gln Pro Phe Lys
275 280 285
Asp Leu Gly Asn Leu Arg Tyr Trp Leu Glu Glu Ala Glu Cys Arg Asp
290 295 300
Gln Tyr Ser Val Ile Phe Glu Ser Gly Asp Arg Thr Ser Ile Phe Trp
305 310 315 320
Asn Asp Val Lys Asp Pro Val Ser Ile Glu Glu Arg Ala Arg Trp Thr
325 330 335
Glu Thr Tyr Val Arg Trp Ser Pro Lys Gly Thr Tyr Leu Ala Thr Phe
340 345 350
His Gln Arg Gly Ile Ala Leu Trp Gly Gly Glu Lys Phe Lys Gln Ile
355 360 365
Gln Arg Phe Ser His Gln Gly Val Gln Leu Ile Asp Phe Ser Pro Cys
370 375 380
Glu Arg Tyr Leu Val Thr Phe Ser Pro Leu Met Asp Thr Gln Asp Asp
385 390 395 400
Pro Gln Ala Ile Ile Ile Trp Asp Ile Leu Thr Gly His Lys Lys Arg
405 410 415
Gly Phe His Cys Glu Ser Ser Ala His Trp Pro Ile Phe Lys Trp Ser
420 425 430
His Asp Gly Lys Phe Phe Ala Arg Met Thr Leu Asp Thr Leu Ser Ile
435 440 445
Tyr Glu Thr Pro Ser Met Gly Leu Leu Asp Lys Lys Ser Leu Lys Ile
450 455 460
Ser Gly Ile Lys Asp Phe Ser Trp Ser Pro Gly Gly Asn Ile Ile Ala
465 470 475 480
Phe Trp Val Pro Glu Asp Lys Asp Ile Pro Ala Arg Val Thr Leu Met
485 490 495
Gln Leu Pro Thr Arg Gln Glu Ile Arg Val Arg Asn Leu Phe Asn Val
500 505 510
Val Asp Cys Lys Leu His Trp Gln Lys Asn Gly Asp Tyr Leu Cys Val
515 520 525
Lys Val Asp Arg Thr Pro Lys Gly Thr Gln Gly Val Val Thr Asn Phe
530 535 540
Glu Ile Phe Arg Met Arg Glu Lys Gln Val Pro Val Asp Val Val Glu
545 550 555 560
Met Lys Glu Thr Ile Ile Ala Phe Ala Trp Glu Pro Asn Gly Ser Lys
565 570 575
Phe Ala Val Leu His Gly Glu Ala Pro Arg Ile Ser Val Ser Phe Tyr
580 585 590
His Val Lys Asn Asn Gly Lys Ile Glu Leu Ile Lys Met Phe Asp Lys
595 600 605
Gln Gln Ala Asn Thr Ile Phe Trp Ser Pro Gln Gly Gln Phe Val Val
610 615 620
Leu Ala Gly Leu Arg Ser Met Asn Gly Ala Leu Ala Phe Val Asp Thr
625 630 635 640
Ser Asp Cys Thr Val Met Asn Ile Ala Glu His Tyr Met Ala Ser Asp
645 650 655
Val Glu Trp Asp Pro Thr Gly Arg Tyr Val Val Thr Ser Val Ser Trp
660 665 670
Trp Ser His Lys Val Asp Asn Ala Tyr Trp Leu Trp Thr Phe Gln Gly
675 680 685
Arg Leu Leu Gln Lys Asn Asn Lys Asp Arg Phe Cys Gln Leu Leu Trp
690 695 700
Arg Pro Arg Pro Pro Thr Leu Leu Ser Gln Glu Gln Ile Lys Gln Ile
705 710 715 720
Lys Lys Asp Leu Lys Lys Tyr Ser Lys Ile Phe Glu Gln Lys Asp Arg
725 730 735
Leu Ser Gln Ser Lys Ala Ser Lys Glu Leu Val Glu Arg Arg Arg Thr
740 745 750
Met Met Glu Asp Phe Arg Lys Tyr Arg Lys Met Ala Gln Glu Leu Tyr
755 760 765
Met Glu Gln Lys Asn Glu Arg Leu Glu Leu Arg Gly Gly Val Asp Thr
770 775 780
Asp Glu Leu Asp Ser Asn Val Asp Asp Trp Glu Glu Glu Thr Ile Glu
785 790 795 800
Phe Phe Val Thr Glu Glu Ile Ile Pro Leu Gly Asn Gln Glu
805 810
<210>105
<211>160
<212>PRT
<213>人
<400>105
Met Ser Asp Asn Asp Asp Ile Glu Val Glu Ser Asp Glu Glu Gln Pro
1 5 10 15
Arg Phe Gln Ser Ala Ala Asp Lys Arg Ala His His Asn Ala Leu Glu
20 25 30
Arg Lys Arg Arg Asp His Ile Lys Asp Ser Phe His Ser Leu Arg Asp
35 40 45
Ser Val Pro Ser Leu Gln Gly Glu Lys Ala Ser Arg Ala Gln Ile Leu
50 55 60
Asp Lys Ala Thr Glu Tyr Ile Gln Tyr Met Arg Arg Lys Asn His Thr
65 70 75 80
His Gln Gln Asp Ile Asp Asp Leu Lys Arg Gln Asn Ala Leu Leu Glu
85 90 95
Gln Gln Val Arg Ala Leu Glu Lys Ala Arg Ser Ser Ala Gln Leu Gln
100 105 110
Thr Asn Tyr Pro Ser Ser Asp Asn Ser Leu Tyr Thr Asn Ala Lys Gly
115 120 125
Ser Thr Ile Ser Ala Phe Asp Gly Gly Ser Asp Ser Ser Ser Glu Ser
130 135 140
Glu Pro Glu Glu Pro Gln Ser Arg Lys Lys Leu Arg Met Glu Ala Ser
145 150 155 160
<210>106
<211>2715
<212>PRT
<213>人
<400>106
Met Ala Ala Ala Ala Gly Gly Gly Ser Cys Pro Gly Pro Gly Ser Ala
1 5 10 15
Arg Gly Arg Phe Pro Gly Arg Pro Arg Gly Ala Gly Gly Gly Gly Gly
20 25 30
Arg Gly Gly Arg Gly Asn Gly Ala Glu Arg Val Arg Val Ala Leu Arg
35 40 45
Arg Gly Gly Gly Ala Thr Gly Pro Gly Gly Ala Glu Pro Gly Glu Asp
50 55 60
Thr Ala Leu Leu Arg Leu Leu Gly Leu Arg Arg Gly Leu Arg Arg Leu
65 70 75 80
Arg Arg Leu Trp Ala Gly Pro Arg Val Gln Arg Gly Arg Gly Arg Gly
85 90 95
Arg Gly Arg Gly Trp Gly Pro Ser Arg Gly Cys Val Pro Glu Glu Glu
100 105 110
Ser Ser Asp Gly Glu Ser Asp Glu Glu Glu Phe Gln Gly Phe His Ser
115 120 125
Asp Glu Asp Val Ala Pro Ser Ser Leu Arg Ser Ala Leu Arg Ser Gln
130 135 140
Arg Gly Arg Ala Pro Arg Gly Arg Gly Arg Lys His Lys Thr Thr Pro
145 150 155 160
Leu Pro Pro Pro Arg Leu Ala Asp Val Ala Pro Thr Pro Pro Lys Thr
165 170 175
Pro Ala Arg Lys Arg Gly Glu Glu Gly Thr Glu Arg Met Val Gln Ala
180 185 190
Leu Thr Glu Leu Leu Arg Arg Ala Gln Ala Pro Gln Ala Pro Arg Ser
195 200 205
Arg Ala Cys Glu Pro Ser Thr Pro Arg Arg Ser Arg Gly Arg Pro Pro
210 215 220
Gly Arg Pro Ala Gly Pro Cys Arg Arg Lys Gln Gln Ala Val Val Val
225 230 235 240
Ala Glu Ala Ala Val Thr Ile Pro Lys Pro Glu Pro Pro Pro Pro Val
245 250 255
Val Pro Val Lys His Gln Thr Gly Ser Trp Lys Cys Lys Glu Gly Pro
260 265 270
Gly Pro Gly Pro Gly Thr Pro Arg Arg Gly Gly Gln Ser Ser Arg Gly
275 280 285
Gly Arg Gly Gly Arg Gly Arg Gly Arg Gly Gly Gly Leu Pro Phe Val
290 295 300
Ile Lys Phe Val Ser Arg Ala Lys Lys Val Lys Met Gly Gln Leu Ser
305 310 315 320
Leu Gly Leu Glu Ser Gly Gln Gly Gln Gly Gln His Glu Glu Ser Trp
325 330 335
Gln Asp Val Pro Gln Arg Arg Val Gly Ser Gly Gln Gly Gly Ser Pro
340 345 350
Cys Trp Lys Lys Gln Glu Gln Lys Leu Asp Asp Glu Glu Glu Glu Lys
355 360 365
Lys Glu Glu Glu Glu Lys Asp Lys Glu Gly Glu Glu Lys Glu Glu Arg
370 375 380
Ala Val Ala Glu Glu Met Met Pro Ala Ala Glu Lys Glu Glu Ala Lys
385 390 395 400
Leu Pro Pro Pro Pro Leu Thr Pro Pro Ala Pro Ser Pro Pro Pro Pro
405 410 415
Leu Pro Pro Pro Ser Thr Ser Pro Pro Pro Pro Leu Cys Pro Pro Pro
420 425 430
Pro Pro Pro Val Ser Pro Pro Pro Leu Pro Ser Pro Pro Pro Pro Pro
435 440 445
Ala Gln Glu Glu Gln Glu Glu Ser Pro Pro Pro Val Val Pro Ala Thr
450 455 460
Cys Ser Arg Lys Arg Gly Arg Pro Pro Leu Thr Pro Ser Gln Arg Ala
465 470 475 480
Glu Arg Glu Ala Ala Arg Ala Gly Pro Glu Gly Thr Ser Pro Pro Thr
485 490 495
Pro Thr Pro Ser Thr Ala Thr Gly Gly Pro Pro Glu Asp Ser Pro Thr
500 505 510
Val Ala Pro Lys Ser Thr Thr Phe Leu Lys Asn Ile Arg Gln Phe Ile
515 520 525
Met Pro Val Val Ser Ala Arg Ser Ser Arg Val Ile Lys Thr Pro Arg
530 535 540
Arg Phe Met Asp Glu Asp Pro Pro Lys Pro Pro Lys Val Glu Val Ser
545 550 555 560
Pro Val Leu Arg Pro Pro Ile Thr Thr Ser Pro Pro Val Pro Gln Glu
565 570 575
Pro Ala Pro Val Pro Ser Pro Pro Arg Ala Pro Thr Pro Pro Ser Thr
580 585 590
Pro Val Pro Leu Pro Glu Lys Arg Arg Ser Ile Leu Arg Glu Pro Thr
595 600 605
Phe Arg Trp Thr Ser Leu Thr Arg Glu Leu Pro Pro Pro Pro Pro Ala
610 615 620
Pro Pro Pro Pro Pro Ala Pro Ser Pro Pro Pro Ala Pro Ala Thr Ser
625 630 635 640
Ser Arg Arg Pro Leu Leu Leu Arg Ala Pro Gln Phe Thr Pro Ser Glu
645 650 655
Ala His Leu Lys Ile Tyr Glu Ser Val Leu Thr Pro Pro Pro Leu Gly
660 665 670
Ala Pro Glu Ala Pro Glu Pro Glu Pro Pro Pro Ala Asp Asp Ser Pro
675 680 685
Ala Glu Pro Glu Pro Arg Ala Val Gly Arg Thr Asn His Leu Ser Leu
690 695 700
Pro Arg Phe Ala Pro Val Val Thr Thr Pro Val Lys Ala Glu Val Ser
705 710 715 720
Pro His Gly Ala Pro Ala Leu Ser Asn Gly Pro Gln Thr Gln Ala Gln
725 730 735
Leu Leu Gln Pro Leu Gln Ala Leu Gln Thr Gln Leu Leu Pro Gln Ala
740 745 750
Leu Pro Pro Pro Gln Pro Gln Leu Gln Pro Pro Pro Ser Pro Gln Gln
755 760 765
Met Pro Pro Leu Glu Lys Ala Arg Ile Ala Gly Val Gly Ser Leu Pro
770 775 780
Leu Ser Gly ValGlu Glu Lys Met Phe Ser Leu Leu Lys Arg Ala Lys
785 790 795 800
Val Gln Leu Phe Lys Ile Asp Gln Gln Gln Gln Gln Lys Val Ala Ala
805 810 815
Ser Met Pro Leu Ser Pro Gly Gly Gln Met Glu Glu Val Ala Gly Ala
820 825 830
Val Lys Gln Ile Ser Asp Arg Gly Pro Val Arg Ser Glu Asp Glu Ser
835 840 845
Val Glu Ala Lys Arg Glu Arg Pro Ser Gly Pro Glu Ser Pro Val Gln
850 855 860
Gly Pro Arg Ile Lys His Val Cys Arg His Ala Ala Val Ala Leu Gly
865 870 875 880
Gln Ala Arg Ala Met Val Pro Glu Asp Val Pro Arg Leu Ser Ala Leu
885 890 895
Pro Leu Arg Asp Arg Gln Asp Leu Ala Thr Glu Asp Thr Ser Ser Ala
900 905 910
Ser Glu Thr Glu Ser Val Pro Ser Arg Ser Arg Arg Gly Lys Val Glu
915 920 925
Ala Ala Gly Pro Gly Gly Glu Ser Glu Pro Thr Gly Ser Gly Gly Thr
930 935 940
Leu Ala His Thr Pro Arg Arg Ser Leu Pro Ser His His Gly Lys Lys
945 950 955 960
Met Arg Met Ala Arg Cys Gly His Cys Arg Gly Cys Leu Arg Val Gln
965 970 975
Asp Cys Gly Ser Cys Val Asn Cys Leu Asp Lys Pro Lys Phe Gly Gly
980 985 990
Pro Asn Thr Lys Lys Gln Cys Cys Val Tyr Arg Lys Cys Asp Lys Ile
995 1000 1005
Glu Ala Arg Lys Met Glu Arg Leu Ala Lys Lys Gly Arg Thr Ile
1010 1015 1020
Val Lys Thr Leu Leu Pro Trp Asp Ser Asp Glu Ser Pro Glu Ala
1025 1030 1035
Ser Pro Gly Pro Pro Gly Pro Arg Arg Gly Ala Gly Ala Gly Gly
1040 1045 1050
Pro Arg Glu Glu Val Val Ala His Pro Gly Pro Glu Glu Gln Asp
1055 1060 1065
Ser Leu Leu Gln Arg Lys Ser Ala Arg Arg Cys Val Lys Gln Arg
1070 1075 1080
Pro Ser Tyr Asp Ile Phe Glu Asp Ser Asp Asp Ser Glu Pro Gly
1085 1090 1095
Gly Pro Pro Ala Pro Arg Arg Arg Thr Pro Arg Glu Asn Glu Leu
1100 1105 1110
Pro Leu Pro Glu Pro Glu Glu Gln Ser Arg Pro Arg Lys Pro Thr
1115 1120 1125
Leu Gln Pro Val Leu Gln Leu Lys Ala Arg Arg Arg Leu Asp Lys
1130 1135 1140
Asp Ala Leu Ala Pro Gly Pro Phe Ala Ser Phe Pro Asn Gly Trp
1145 1150 1155
Thr Gly Lys Gln Lys Ser Pro Asp Gly Val His Arg Val Arg Val
1160 1165 1170
Asp Phe Lys Glu Asp Cys Asp Leu Glu Asn Val Trp Leu Met Gly
1175 1180 1185
Gly Leu Ser Val Leu Thr Ser Val Pro Gly Gly Pro Pro Met Val
1190 1195 1200
Cys Leu Leu Cys Ala Ser Lys Gly Leu His Glu Leu Val Phe Cys
1205 1210 1215
Gln Val Cys Cys Asp Pro Phe His Pro Phe Cys Leu Glu Glu Ala
1220 1225 1230
Glu Arg Pro Leu Pro Gln His His Asp Thr Trp Cys Cys Arg Arg
1235 1240 1245
Cys Lys Phe Cys His Val Cys Gly Arg Lys Gly Arg Gly Ser Lys
1250 1255 1260
His Leu Leu Glu Cys Glu Arg Cys Arg His Ala Tyr His Pro Ala
1265 1270 1275
Cys Leu Gly Pro Ser Tyr Pro Thr Arg Ala Thr Arg Lys Arg Arg
1280 1285 1290
His Trp Ile Cys Ser Ala Cys Val Arg Cys Lys Ser Cys Gly Ala
1295 1300 1305
Thr Pro Gly Lys Asn Trp Asp Val Glu Trp Ser Gly Asp Tyr Ser
1310 1315 1320
Leu Cys Pro Arg Cys Thr Gln Leu Tyr Glu Lys Gly Asn Tyr Cys
1325 1330 1335
Pro Ile Cys Thr Arg Cys Tyr Glu Asp Asn Asp Tyr Glu Ser Lys
1340 1345 1350
Met Met Gln Cys Ala Gln Cys Asp His Trp Val His Ala Lys Cys
1355 1360 1365
Glu Gly Leu Ser Asp Glu Asp Tyr Glu Ile Leu Ser Gly Leu Pro
1370 1375 1380
Asp Ser Val Leu Tyr Thr Cys Gly Pro Cys Ala Gly Ala Ala Gln
1385 1390 1395
Pro Arg Trp Arg Glu Ala Leu Ser Gly Ala Leu Gln Gly Gly Leu
1400 1405 1410
Arg Gln Val Leu Gln Gly Leu Leu Ser Ser Lys Val Val Gly Pro
1415 1420 1425
Leu Leu Leu Cys Thr Gln Cys Gly Pro Asp Gly Lys Gln Leu His
1430 1435 1440
Pro Gly Pro Cys Gly Leu Gln Ala Val Ser Gln Arg Phe Glu Asp
1445 1450 1455
Gly His Tyr Lys Ser Val His Ser Phe Met Glu Asp Met Val Gly
1460 1465 1470
Ile Leu Met Arg His Ser Glu Glu Gly Glu Thr Pro Asp Arg Arg
1475 1480 1485
Ala Gly Gly Gln Met Lys Gly Leu Leu Leu Lys Leu Leu Glu Ser
1490 1495 1500
Ala Phe Gly Trp Phe Asp Ala His Asp Pro Lys Tyr Trp Arg Arg
1505 1510 1515
Ser Thr Arg Leu Pro Asn Gly Val Leu Pro Asn Ala Val Leu Pro
1520 1525 1530
Pro Ser Leu Asp His Val Tyr Ala Gln Trp Arg Gln Gln Glu Pro
1535 1540 1545
Glu Thr Pro Glu Ser Gly Gln Pro Pro Gly Asp Pro Ser Ala Ala
1550 1555 1560
Phe Gln Gly Lys Asp Pro Ala Ala Phe Ser His Leu Glu Asp Pro
1565 1570 1575
Arg Gln Cys Ala Leu Cys Leu Lys Tyr Gly Asp Ala Asp Ser Lys
1580 1585 1590
Glu Ala Gly Arg Leu Leu Tyr Ile Gly Gln Asn Glu Trp Thr His
1595 1600 1605
Val Asn Cys Ala Ile Trp Ser Ala Glu Val Phe Glu Glu Asn Asp
1610 1615 1620
Gly Ser Leu Lys Asn Val His Ala Ala Val Ala Arg Gly Arg Gln
1625 1630 1635
Met Arg Cys Glu Leu Cys Leu Lys Pro Gly Ala Thr Val Gly Cys
1640 1645 1650
Cys Leu Ser Ser Cys Leu Ser Asn Phe His Phe Met Cys Ala Arg
1655 1660 1665
Ala Ser Tyr Cys Ile Phe Gln Asp Asp Lys Lys Val Phe Cys Gln
1670 1675 1680
Lys His Thr Asp Leu Leu Asp Gly Lys Glu Ile Val Asn Pro Asp
1685 1690 1695
Gly Phe Asp Val Leu Arg Arg Val Tyr Val Asp Phe Glu Gly Ile
1700 1705 1710
Asn Phe Lys Arg Lys Phe Leu Thr Gly Leu Glu Pro Asp Ala Ile
1715 1720 1725
Asn Val Leu Ile Gly Ser Ile Arg Ile Asp Ser Leu Gly Thr Leu
1730 1735 1740
Ser Asp Leu Ser Asp Cys Glu Gly Arg Leu Phe Pro Ile Gly Tyr
1745 1750 1755
Gln Cys Ser Arg Leu Tyr Trp Ser Thr Val Asp Ala Arg Arg Arg
1760 1765 1770
Cys Trp Tyr Arg Cys Arg Ile Leu Glu Tyr Arg Pro Trp Gly Pro
1775 1780 1785
Arg Glu Glu Pro Ala His Leu Glu Ala Ala Glu Glu Asn Gln Thr
1790 1795 1800
Ile Val His Ser Pro Ala Pro Ser Ser Glu Pro Pro Gly Gly Glu
1805 1810 1815
Asp Pro Pro Leu Asp Thr Asp Val Leu Val Pro Gly Ala Pro Glu
1820 1825 1830
Arg His Ser Pro Ile Gln Asn Leu Asp Pro Pro Leu Arg Pro Asp
1835 1840 1845
Ser Gly Ser Ala Pro Pro Pro Ala Pro Arg Ser Phe Ser Gly Ala
1850 1855 1860
Arg Ile Lys Val Pro Asn Tyr Ser Pro Ser Arg Arg Pro Leu Gly
1865 1870 1875
Gly Val Ser Phe Gly Pro Leu Pro Ser Pro Gly Ser Pro Ser Ser
1880 1885 1890
Leu Thr His His Ile Pro Thr Val Gly Asp Pro Asp Phe Pro Ala
1895 1900 1905
Pro Pro Arg Arg Ser Arg Arg Pro Ser Pro Leu Ala Pro Arg Pro
1910 1915 1920
Pro Pro Ser Arg Trp Ala Ser Pro Pro Leu Lys Thr Ser Pro Gln
1925 1930 1935
Leu Arg Val Pro Pro Pro Thr Ser Val Val Thr Ala Leu Thr Pro
1940 1945 1950
Thr Ser Gly Glu Leu Ala Pro Pro Gly Pro Ala Pro Ser Pro Pro
1955 1960 1965
Pro Pro Glu Asp Leu Gly Pro Asp Phe Glu Asp Met Glu Val Val
1970 1975 1980
Ser Gly Leu Ser Ala Ala Asp Leu Asp Phe Ala Ala Ser Leu Leu
1985 1990 1995
Gly Thr Glu Pro Phe Gln Glu Glu Ile Val Ala Ala Gly Ala Met
2000 2005 2010
Gly Ser Ser His Gly Gly Pro Gly Asp Ser Ser Glu Glu Glu Ser
2015 2020 2025
Ser Pro Thr Ser Arg Tyr Ile His Phe Pro Val Thr Val Val Ser
2030 2035 2040
Ala Pro Gly Leu Ala Pro Ser Ala Thr Pro Gly Ala Pro Arg Ile
2045 2050 2055
Glu Gln Leu Asp Gly Val Asp Asp Gly Thr Asp Ser Glu Ala Glu
2060 2065 2070
Ala Val Gln Gln Pro Arg Gly Gln Gly Thr Pro Pro Ser Gly Pro
2075 2080 2085
Gly Val Val Arg Ala Gly Val Leu Gly Ala Ala Gly Asp Arg Ala
2090 2095 2100
Arg Pro Pro Glu Asp Leu Pro Ser Glu Ile Val Asp Phe Val Leu
2105 2110 2115
Lys Asn Leu Gly Gly Pro Gly Asp Gly Gly Ala Gly Pro Arg Glu
2120 2125 2130
Glu Ser Leu Pro Pro Ala Pro Pro Leu Ala Asn Gly Ser Gln Pro
2135 2140 2145
Ser Gln Gly Leu Thr Ala Ser Pro Ala Asp Pro Thr Arg Thr Phe
2150 2155 2160
Ala Trp Leu Pro Gly Ala Pro Gly ValArg Val Leu Ser Leu Gly
2165 2170 2175
Pro Ala Pro Glu Pro Pro Lys Pro Ala Thr Ser Lys Ile Ile Leu
2180 2185 2190
Val Asn Lys Leu Gly Gln Val Phe Val Lys Met Ala Gly Glu Gly
2195 2200 2205
Glu Pro Val Pro Pro Pro Val Lys Gln Pro Pro Leu Pro Pro Thr
2210 2215 2220
Ile Ser Pro Thr Ala Pro Thr Ser Trp Thr Leu Pro Pro Gly Pro
2225 2230 2235
Leu Leu Gly Val Leu Pro Val Val Gly Val Val Arg Pro Ala Pro
2240 2245 2250
Pro Pro Pro Pro Pro Pro Leu Thr Leu Val Leu Ser Ser Gly Pro
2255 2260 2265
Ala Ser Pro Pro Arg Gln Ala Ile Arg Val Lys Arg Val Ser Thr
2270 2275 2280
Phe Ser Gly Arg Ser Pro Pro Ala Pro Pro Pro Tyr Lys Ala Pro
2285 2290 2295
Arg Leu Asp Glu Asp Gly Glu Ala Ser Glu Asp Thr Pro Gln Val
2300 2305 2310
Pro Gly Leu Gly Ser Gly Gly Phe Ser Arg Val Arg Met Lys Thr
2315 2320 2325
Pro Thr Val Arg Gly Val Leu Asp Leu Asp Arg Pro Gly Glu Pro
2330 2335 2340
Ala Gly Glu Glu Ser Pro Gly Pro Leu Gln Glu Arg Ser Pro Leu
2345 2350 2355
Leu Pro Leu Pro Glu Asp Gly Pro Pro Gln Val Pro Asp Gly Pro
2360 2365 2370
Pro Asp Leu Leu Leu Glu Ser Gln Trp His His Tyr Ser Gly Glu
2375 2380 2385
Ala Ser Ser Ser Glu Glu Glu Pro Pro Ser Pro Asp Asp Lys Glu
2390 2395 2400
Asn Gln Ala Pro Lys Arg Thr Gly Pro His Leu Arg Phe Glu Ile
2405 2410 2415
Ser Ser Glu Asp Gly Phe Ser Val Glu Ala Glu Ser Leu Glu Gly
2420 2425 2430
Ala Trp Arg Thr Leu Ile Glu Lys Val Gln Glu Ala Arg Gly His
2435 2440 2445
Ala Arg Leu Arg His Leu Ser Phe Ser Gly Met Ser Gly Ala Arg
2450 2455 2460
Leu Leu Gly Ile His His Asp Ala Val Ile Phe Leu Ala Glu Gln
2465 2470 2475
Leu Pro Gly Ala Gln Arg Cys Gln His Tyr Lys Phe Arg Tyr His
2480 2485 2490
Gln Gln Gly Glu Gly Gln Glu Glu Pro Pro Leu Asn Pro His Gly
2495 2500 2505
Ala Ala Arg Ala Glu Val Tyr Leu Arg Lys Cys Thr Phe Asp Met
2510 2515 2520
Phe Asn Phe Leu Ala Ser Gln His Arg Val Leu Pro Glu Gly Ala
2525 2530 2535
Thr Cys Asp Glu Glu Glu Asp Glu Val Gln Leu Arg Ser Thr Arg
2540 2545 2550
Arg Ala Thr Ser Leu Glu Leu Pro Met Ala Met Arg Phe Arg His
2555 2560 2565
Leu Lys Lys Thr Ser Lys Glu Ala Val Gly Val Tyr Arg Ser Ala
2570 2575 2580
Ile His Gly Arg Gly Leu Phe Cys Lys Arg Asn Ile Asp Ala Gly
2585 2590 2595
Glu Met Val Ile Glu Tyr Ser Gly Ile Val Ile Arg Ser Val Leu
2600 2605 2610
Thr Asp Lys Arg Glu Lys Phe Tyr Asp Gly Lys Gly Ile Gly Cys
2615 2620 2625
Tyr Met Phe Arg Met Asp Asp Phe Asp Val Val Asp Ala Thr Met
2630 2635 2640
His Gly Asn Ala Ala Arg Phe Ile Asn His Ser Cys Glu Pro Asn
2645 2650 2655
Cys Phe Ser Arg Val Ile His Val Glu Gly Gln Lys His Ile Val
2660 2665 2670
Ile Phe Ala Leu Arg Arg Ile Leu Arg Gly Glu Glu Leu Thr Tyr
2675 2680 2685
Asp Tyr Lys Phe Pro Ile Glu Asp Ala Ser Asn Lys Leu Pro Cys
2690 2695 2700
Asn Cys Gly Ala Lys Arg Cys Arg Arg Phe Leu Asn
2705 2710 2715
<210>107
<211>605
<212>PRT
<213>人
<400>107
Met Gln Cys Cys Gly Leu Val His Arg Arg Arg Val Arg Val Ser Tyr
1 5 10 15
Gly Ser Ala Asp Ser Tyr Thr Ser Arg Pro Ser Asp Ser Asp Val Ser
20 25 30
Leu Glu Glu Asp Arg Glu Ala Val Arg Arg Glu Ala Glu Arg Gln Ala
35 40 45
Gln Ala Gln Leu Glu Lys Ala Lys Thr Lys Pro Val Ala Phe Ala Val
50 55 60
Arg Thr Asn Val Ser Tyr Ser Ala Ala His Glu Asp Asp Val Pro Val
65 70 75 80
Pro Gly Met Ala Ile Ser Phe Glu Ala Lys Asp Phe Leu His Val Lys
85 90 95
Glu Lys Phe Asn Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu Gly
100 105 110
Cys Glu Ile Gly Phe Ile Pro Ser Pro Val Lys Leu Glu Asn Met Arg
115 120 125
Leu Gln His Glu Gln Arg Ala Lys Gln Gly Lys Phe Tyr Ser Ser Lys
130 135 140
Ser Gly Gly Asn Ser Ser Ser Ser Leu Gly Asp Ile Val Pro Ser Ser
145 150 155 160
Arg Lys Ser Thr Pro Pro Ser Ser Ala Ile Asp Ile Asp Ala Thr Gly
165 170 175
Leu Asp Ala Glu Glu Asn Asp Ile Pro Ala Asn His Arg Ser Pro Lys
180 185 190
Pro Ser Ala Asn Ser Val Thr Ser Pro His Ser Lys Glu Lys Arg Met
195 200 205
Pro Phe Phe Lys Lys Thr Glu His Thr Pro Pro Tyr Asp Val Val Pro
210 215 220
Ser Met Arg Pro Val Val Leu Val Gly Pro Ser Leu Lys Gly Tyr Glu
225 230 235 240
Val Thr Asp Met Met Gln Lys Ala Leu Phe Asp Phe Leu Lys His Arg
245 250 255
Phe Glu Gly Arg Ile Ser Ile Thr Arg Val Thr Ala Asp Ile Ser Leu
260 265 270
Ala Lys Arg Ser Val Leu Asn Asn Pro Ser Lys His Ala Ile Ile Glu
275 280 285
Arg Ser Asn Thr Arg Ser Ser Leu Ala Glu Val Gln Ser Glu Ile Glu
290 295 300
Arg Ile Phe Glu Leu Ala Arg Thr Leu Gln Leu Val Val Leu Asp Ala
305 310 315 320
Asp Thr Ile Asn His Pro Ala Gln Leu Ser Lys Thr Ser Leu Ala Pro
325 330 335
Ile Ile Val Tyr Val Lys Ile Ser Ser Pro Lys Val Leu Gln Arg Leu
340 345 350
Ile Lys Ser Arg Gly Lys Ser Gln Ala Lys His Leu Asn Val Gln Met
355 360 365
Val Ala Ala Asp Lys Leu Ala Gln Cys Pro Pro Glu Leu Phe Asp Val
370 375 380
lle Leu Asp Glu Asn Gln Leu Glu Asp Ala Cys Glu His Leu Ala Asp
385 390 395 400
Tyr Leu Glu Ala Tyr Trp Lys Ala Thr His Pro Pro Ser Ser Ser Leu
405 410 415
Pro Asn Pro Leu Leu Ser Arg Thr Leu Ala Thr Ser Ser Leu Pro Leu
420 425 430
Ser Pro Thr Leu Ala Ser Asn Ser Gln Gly Ser Gln Gly Asp Gln Arg
435 440 445
Thr Asp Arg Ser Ala Pro Ile Arg Ser Ala Ser Gln Ala Glu Glu Glu
450 455 460
Pro Ser Val Glu Pro Val Lys Lys Ser Gln His Arg Ser Ser Ser Ser
465 470 475 480
Ala Pro His His Asn His Arg Ser Gly Thr Ser Arg Gly Leu Ser Arg
485 490 495
Gln Glu Thr Phe Asp Ser Glu Thr Gln Glu Ser Arg Asp Ser Ala Tyr
500 505 510
Val Glu Pro Lys Glu Asp Tyr Ser His Asp His Val Asp His Tyr Ala
515 520 525
Ser His Arg Asp His Asn His Arg Asp Glu Thr His Gly Ser Ser Asp
530 535 540
His Arg His Arg Glu Ser Arg His Arg Ser Arg Asp Val Asp Arg Glu
545 550 555 560
Gln Asp His Asn Glu Cys Asn Lys Gln Arg Ser Arg His Lys Ser Lys
565 570 575
Asp Arg Tyr Cys Glu Lys Asp Gly Glu Val Ile Ser Lys Lys Arg Asn
580 585 590
Glu Ala Gly Glu Trp Asn Arg Asp Val Tyr Ile Pro Gln
595 600 605
<210>108
<211>562
<212>PRT
<213>人
<400>108
Met Ser Arg Val His Gly Met His Pro Lys Glu Thr Thr Arg Gln Leu
1 5 10 15
Ser Leu Ala Val Lys Asp Gly Leu Ile Val Glu Thr Leu Thr Val Gly
20 25 30
Cys Lys Gly Ser Lys Ala Gly Ile Glu Gln Glu Gly Tyr Trp Leu Pro
35 40 45
Gly Asp Glu Ile Asp Trp Glu Thr Glu Asn His Asp Trp Tyr Cys Phe
50 55 60
Glu Cys His Leu Pro Gly Glu Val Leu Ile Cys Asp Leu Cys Phe Arg
65 70 75 80
Val Tyr His Ser Lys Cys Leu Ser Asp Glu Phe Arg Leu Arg Asp Ser
85 90 95
Ser Ser Pro Trp Gln Cys Pro Val Cys Arg Ser Ile Lys Lys Lys Asn
100 105 110
Thr Asn Lys Gln Glu Met Gly Thr Tyr Leu Arg Phe Ile Val Ser Arg
115 120 125
Met Lys Glu Arg Ala Ile Asp Leu Asn Lys Lys Gly Lys Asp Asn Lys
130 135 140
His Pro Met Tyr Arg Arg Leu Val His Ser Ala Val Asp Val Pro Thr
145 150 155 160
Ile Gln Glu Lys Val Asn Glu Gly Lys Tyr Arg Ser Tyr Glu Glu Phe
165 170 175
Lys Ala Asp Ala Gln Leu Leu Leu His Asn Thr Val Ile Phe Tyr Gly
180 185 190
Ala Asp Ser Glu Gln Ala Asp Ile Ala Arg Met Leu Tyr Lys Asp Thr
195 200 205
Cys His Glu Leu Asp Glu Leu Gln Leu Cys Lys Asn Cys Phe Tyr Leu
210 215 220
Ser Asn Ala Arg Pro Asp Asn Trp Phe Cys Tyr Pro Cys Ile Pro Asn
225 230 235 240
His Glu Leu Val Trp Ala Lys Met Lys Gly Phe Gly Phe Trp Pro Ala
245 250 255
Lys Val Met Gln Lys Glu Asp Asn Gln Val Asp Val Arg Phe Phe Gly
260 265 270
His His His Gln Arg Ala Trp Ile Pro Ser Glu Asn Ile Gln Asp Ile
275 280 285
Thr Val Asn Ile His Arg Leu His Val Lys Arg Ser Met Gly Trp Lys
290 295 300
Lys Ala Cys Asp Glu Leu Glu Leu His Gln Arg Phe Leu Arg Glu Gly
305 310 315 320
Arg Phe Trp Lys Ser Lys Asn Glu Asp Arg Gly Glu Glu Glu Ala Glu
325 330 335
Ser Ser Ile Ser Ser Thr Ser Asn Glu Gln Leu Lys Val Thr Gln Glu
340 345 350
Pro Arg Ala Lys Lys Gly Arg Arg Asn Gln Ser Val Glu Pro Lys Lys
355 360 365
Glu Glu Pro Glu Pro Glu Thr Glu Ala Val Ser Ser Ser Gln Glu Ile
370 375 380
Pro Thr Met Pro Gln Pro Ile Glu Lys Val Ser Val Ser Thr Gln Thr
385 390 395 400
Lys Lys Leu Ser Ala Ser Ser Pro Arg Met Leu His Arg Ser Thr Gln
405 410 415
Thr Thr Asn Asp Gly Val Cys Gln Ser Met Cys His Asp Lys Tyr Thr
420 425 430
Lys Ile Phe Asn Asp Phe Lys Asp Arg Met Lys Ser Asp His Lys Arg
435 440 445
Glu Thr Glu Arg Val ValArg Glu Ala Leu Glu Lys Leu Arg Ser Glu
450 455 460
Met Glu Glu Glu Lys Arg Gln Ala Val Asn Lys Ala Val Ala Asn Met
465 470 475 480
Gln Gly Glu Met Asp Arg Lys Cys Lys Gln ValLys Glu Lys Cys Lys
485 490 495
Glu Glu Phe Val Glu Glu Ile Lys Lys Leu Ala Thr Gln His Lys Gln
500 505 510
Leu Ile Ser Gln Thr Lys Lys Lys Gln Trp Cys Tyr Asn Cys Glu Glu
515 520 525
Glu Ala Met Tyr His Cys Cys Trp Asn Thr Ser Tyr Cys Ser Ile Lys
530 535 540
Cys Gln Gln Glu His Trp His Ala Glu His Lys Arg Thr Cys Arg Arg
545 550 555 560
Lys Arg
<210>109
<211>2145
<212>PRT
<213>人
<400>109
Met Ser Asp Arg Ser Gly Pro Thr Ala Lys Gly Lys Asp Gly Lys Lys
1 5 10 15
Tyr Ser Ser Leu Asn Leu Phe Asp Thr Tyr Lys Gly Lys Ser Leu Glu
20 25 30
Ile Gln Lys Pro Ala Val Ala Pro Arg His Gly Leu Gln Ser Leu Gly
35 40 45
Lys Val Ala Ile Ala Arg Arg Met Pro Pro Pro Ala Asn Leu Pro Ser
50 55 60
Leu Lys Ala Glu Asn Lys Gly Asn Asp Pro Asn Val Ser Leu Val Pro
65 70 75 80
Lys Asp Gly Thr Gly Trp Ala Ser Lys Gln Glu Gln Ser Asp Pro Lys
85 90 95
Ser Ser Asp Ala Ser Thr Ala Gln Pro Pro Glu Ser Gln Pro Leu Pro
100 105 110
Ala Ser Gln Thr Pro Ala Ser Asn Gln Pro Lys Arg Pro Pro Ala Ala
115 120 125
Pro Glu Asn Thr Pro Leu Val Pro Ser Gly Val Lys Ser Trp Ala Gln
130 135 140
Ala Ser Val Thr His Gly Ala His Gly Asp Gly Gly Arg Ala Ser Ser
145 150 155 160
Leu Leu Ser Arg Phe Ser Arg Glu Glu Phe Pro Thr Leu Gln Ala Ala
165 170 175
Gly Asp Gln Asp Lys Ala Ala Lys Glu Arg Glu Ser Ala Glu Gln Ser
180 185 190
Ser Gly Pro Gly Pro Ser Leu Arg Pro Gln Asn Ser Thr Thr Trp Arg
195 200 205
Asp Gly Gly Gly Arg Gly Pro Asp Glu Leu Glu Gly Pro Asp Ser Lys
210 215 220
Leu His His Gly His Asp Pro Arg Gly Gly Leu Gln Pro Ser Gly Pro
225 230 235 240
Pro Gln Phe Pro Pro Tyr Arg Gly Met Met Pro Pro Phe Met Tyr Pro
245 250 255
Pro Tyr Leu Pro Phe Pro Pro Pro Tyr Gly Pro Gln Gly Pro Tyr Arg
260 265 270
Tyr Pro Thr Pro Asp Gly Pro Ser Arg Phe Pro Arg Val Ala Gly Pro
275 280 285
Arg Gly Ser Gly Pro Pro Met Arg Leu Val Glu Pro Val Gly Arg Pro
290 295 300
Ser Ile Leu Lys Glu Asp Asn Leu Lys Glu Phe Asp Gln Leu Asp Gln
305 310 315 320
Glu Asn Asp Asp Gly Trp Ala Gly Ala His Glu Glu Val Asp Tyr Thr
325 330 335
Glu Lys Leu Lys Phe Ser Asp Glu Glu Asp Gly Arg Asp Ser Asp Glu
340 345 350
Glu Gly Ala Glu Gly His Arg Asp Ser Gln Ser Ala Ser Gly Glu Glu
355 360 365
Arg Pro Pro Glu Ala Asp Gly Lys Lys Gly Asn Ser Pro Asn Ser Glu
370 375 380
Pro Pro Thr Pro Lys Thr Ala Trp Ala Glu Thr Ser Arg Pro Pro Glu
385 390 395 400
Thr Glu Pro Gly Pro Pro Ala Pro Lys Pro Pro Leu Pro Pro Gly Asp
405 410 415
Tyr Pro Asp Arg Gly Gly Pro Pro Cys Lys Pro Pro Ala Pro Glu Asp
420 425 430
Glu Asp Glu Ala Trp Arg Gln Arg Arg Lys Gln Ser Ser Ser Glu Ile
435 440 445
Ser Leu Ala Val Glu Arg Ala Arg Arg Arg Arg Glu Glu Glu Glu Arg
450 455 460
Arg Met Gln Glu Glu Arg Arg Ala Ala Cys Ala Glu Lys Leu Lys Arg
465 470 475 480
Leu Asp Glu Lys Phe Gly Ala Pro Asp Lys Arg Leu Lys Ala Glu Pro
485 490 495
Ala Ala Pro Pro Ala Ala Pro Ser Thr Pro Ala Pro Pro Pro Ala Val
500 505 510
Pro Lys Glu Leu Pro Ala Pro Pro Ala Pro Pro Pro Ala Ser Ala Pro
515 520 525
Thr Pro Glu Lys Glu Pro Glu Glu Pro Ala Gln Ala Pro Pro Ala Gln
530 535 540
Ser Thr Pro Thr Pro Gly Val Ala Ala Ala Pro Thr Leu Val Ser Gly
545 550 555 560
Gly Gly Ser Thr Ser Ser Thr Ser Ser Gly Ser Phe Glu Ala Ser Pro
565 570 575
Val Glu Pro Gln Leu Pro Ser Lys Glu Gly Pro Glu Pro Pro Glu Glu
580 585 590
Val Pro Pro Pro Thr Thr Pro Pro Val Pro Lys Val Glu Pro Lys Gly
595 600 605
Asp Gly Ile Gly Pro Thr Arg Gln Pro Pro Ser Gln Gly Leu Gly Tyr
610 615 620
Pro Lys Tyr Gln Lys Ser Leu Pro Pro Arg Phe Gln Arg Gln Gln Gln
625 630 635 640
Glu Gln Leu Leu Lys Gln Gln Gln Gln His Gln Trp Gln Gln His Gln
645 650 655
Gln Gly Ser Ala Pro Pro Thr Pro Val Pro Pro Ser Pro Pro Gln Pro
660 665 670
Val Thr Leu Gly Ala Val Pro Ala Pro Gln Ala Pro Pro Pro Pro Pro
675 680 685
Lys Ala Leu Tyr Pro Gly Ala Leu Gly Arg Pro Pro Pro Met Pro Pro
690 695 700
Met Asn Phe Asp Pro Arg Trp Met Met Ile Pro Pro Tyr Val Asp Pro
705 710 715 720
Arg Leu Leu Gln Gly Arg Pro Pro Leu Asp Phe Tyr Pro Pro Gly Val
725 730 735
His Pro Ser Gly Leu Val Pro Arg Glu Arg Ser Asp Ser Gly Gly Ser
740 745 750
Ser Ser Glu Pro Phe Asp Arg His Ala Pro Ala Met Leu Arg Glu Arg
755 760 765
Gly Thr Pro Pro Val Asp Pro Lys Leu Ala Trp Val Gly Asp Val Phe
770 775 780
Thr Ala Thr Pro Ala Glu Pro Arg Pro Leu Thr Ser Pro Leu Arg Gln
785 790 795 800
Ala Ala Asp Glu Asp Asp Lys Gly Met Arg Ser Glu Thr Pro Pro Val
805 810 815
Pro Pro Pro Pro Pro Tyr Leu Ala Ser Tyr Pro Gly Phe Pro Glu Asn
820 825 830
Gly Ala Pro Gly Pro Pro Ile Ser Arg Phe Pro Leu Glu Glu Pro Gly
835 840 845
Pro Arg Pro Leu Pro Trp Pro Pro Gly Ser Asp Glu Val Ala Lys Ile
850 855 860
Gln Thr Pro Pro Pro Lys Lys Glu Pro Pro Lys Glu Glu Thr Ala Gln
865 870 875 880
Leu Thr Gly Pro Glu Ala Gly Arg Lys Pro Ala Arg Gly Val Gly Ser
885 890 895
Gly Gly Gln Gly Pro Pro Pro Pro Arg Arg Glu Ser Arg Thr Glu Thr
900 905 910
Arg Trp Gly Pro Arg Pro Gly Ser Ser Arg Arg Gly Ile Pro Pro Glu
915 920 925
Glu Pro Gly Ala Pro Pro Arg Arg Ala Gly Pro Ile Lys Lys Pro Pro
930 935 940
Pro Pro Thr Lys Val Glu Glu Leu Pro Pro Lys Pro Leu Glu Gln Gly
945 950 955 960
Asp Glu Thr Pro Lys Pro Pro Lys Pro Asp Pro Leu Lys Ile Thr Lys
965 970 975
Gly Lys Leu Gly Gly Pro Lys Glu Thr Pro Pro Asn Gly Asn Leu Ser
980 985 990
Pro Ala Pro Arg Leu Arg Arg Asp Tyr Ser Tyr Glu Arg Val Gly Pro
995 1000 1005
Thr Ser Cys Arg Gly Arg Gly Arg Gly Glu Tyr Phe Ala Arg Gly
1010 1015 1020
Arg Gly Phe Arg Gly Thr Tyr Gly Gly Arg Gly Arg Gly Ala Arg
1025 1030 1035
Ser Arg Glu Phe Arg Ser Tyr Arg Glu Phe Arg Gly Asp Asp Gly
1040 1045 1050
Arg Gly Gly Gly Thr Gly Gly Pro Asn His Pro Pro Ala Pro Arg
1055 1060 1065
Gly Arg Thr Ala Ser Glu Thr Arg Ser Glu Gly Ser Glu Tyr Glu
1070 1075 1080
Glu Ile Pro Lys Arg Arg Arg Gln Arg Gly Ser Glu Thr Gly Ser
1085 1090 1095
Glu Thr His Glu Ser Asp Leu Ala Pro Ser Asp Lys Glu Ala Pro
1100 1105 1110
Thr Pro Lys Glu Gly Thr Leu Thr Gln Val Pro Leu Ala Pro Pro
1115 1120 1125
Pro Pro Gly Ala Pro Pro Ser Pro Ala Pro Ala Arg Phe Thr Ala
1130 1135 1140
Arg Gly Gly Arg Val Phe Thr Pro Arg Gly Val Pro Ser Arg Arg
1145 1150 1155
Gly Arg Gly Gly Gly Arg Pro Pro Pro Gln Val Cys Pro Gly Trp
1160 1165 1170
Ser Pro Pro Ala Lys Ser Leu Ala Pro Lys Lys Pro Pro Thr Gly
1175 1180 1185
Pro Leu Pro Pro Ser Lys Glu Pro Leu Lys Glu Lys Leu Ile Pro
1190 1195 1200
Gly Pro Leu Ser Pro Val Ala Arg Gly Gly Ser Asn Gly Gly Ser
1205 1210 1215
Asn Val Gly Met Glu Asp Gly Glu Arg Pro Arg Arg Arg Arg His
1220 1225 1230
Gly Arg Ala Gln Gln Gln Asp Lys Pro Pro Arg Phe Arg Arg Leu
1235 1240 1245
Lys Gln Glu Arg Glu Asn Ala Ala Arg Gly Ser Glu Gly Lys Pro
1250 1255 1260
Ser Leu Thr Leu Pro Ala Ser Ala Pro Ala Pro Glu Glu Ala Leu
1265 1270 1275
Thr Thr Val Thr Val Ala Pro Ala Pro Arg Arg Ala Ala Ala Lys
1280 1285 1290
Ser Pro Asp Leu Ser Asn Gln Asn Ser Asp Gln Ala Asn Glu Glu
1295 1300 1305
Trp Glu Thr Ala Ser Glu Ser Ser Asp Phe Thr Ser Glu Arg Arg
1310 1315 1320
Gly Asp Lys Glu Ala Pro Pro Pro Val Leu Leu Thr Pro Lys Ala
1325 1330 1335
Val Gly Thr Pro Gly Gly Gly Gly Gly Gly Ala Val Pro Gly Ile
1340 1345 1350
Ser Ala Met Ser Arg Gly Asp Leu Ser Gln Arg Ala Lys Asp Leu
1355 1360 1365
Ser Lys Arg Ser Phe Ser Ser Gln Arg Pro Gly Met Glu Arg Gln
1370 1375 1380
Asn Arg Arg Pro Gly Pro Gly Gly Lys Ala Gly Ser Ser Gly Ser
1385 1390 1395
Ser Ser Gly Gly Gly Gly Gly Gly Pro Gly Gly Arg Thr Gly Pro
1400 1405 1410
Gly Arg Gly Asp Lys Arg Ser Trp Pro Ser Pro Lys Asn Arg Ser
1415 1420 1425
Arg Pro Pro Glu Glu Arg Pro Pro Gly Leu Pro Leu Pro Pro Pro
1430 1435 1440
Pro Pro Ser Ser Ser Ala Val Phe Arg Leu Asp Gln Val Ile His
1445 1450 1455
Ser Asn Pro Ala Gly Ile Gln Gln Ala Leu Ala Gln Leu Ser Ser
1460 1465 1470
Arg Gln Gly Ser Val Thr Ala Pro Gly Gly His Pro Arg His Lys
1475 1480 1485
Pro Gly Pro Pro Gln Ala Pro Gln Gly Pro Ser Pro Arg Pro Pro
1490 1495 1500
Thr Arg Tyr Glu Pro Gln Arg Val Asn Ser Gly Leu Ser Ser Asp
1505 1510 1515
Pro His Phe Glu Glu Pro Gly Pro Met Val Arg Gly Val Gly Gly
1520 1525 1530
Thr Pro Arg Asp Ser Ala Gly Val Ser Pro Phe Pro Pro Lys Arg
1535 1540 1545
Arg Glu Arg Pro Pro Arg Lys Pro Glu Leu Leu Gln Glu Glu Ser
1550 1555 1560
Leu Pro Pro Pro His Ser Ser Gly Phe Leu Gly Ser Lys Pro Glu
1565 1570 1575
Gly Pro Gly Pro Gln Ala Glu Ser Arg Asp Thr Gly Thr Glu Ala
1580 1585 1590
Leu Thr Pro His Ile Trp Asn Arg Leu His Thr Ala Thr Ser Arg
1595 1600 1605
Lys Ser Tyr Arg Pro Ser Ser Met Glu Pro Trp Met Glu Pro Leu
1610 1615 1620
Ser Pro Phe Glu Asp Val Ala Gly Thr Glu Met Ser Gln Ser Asp
1625 1630 1635
Ser Gly Val Asp Leu Ser Gly Asp Ser Gln Val Ser Ser Gly Pro
1640 1645 1650
Cys Ser Gln Arg Ser Ser Pro Asp Gly Gly Leu Lys Gly Ala Ala
1655 1660 1665
Glu Gly Pro Pro Lys Arg Pro Gly Gly Ser Ser Pro Leu Asn Ala
1670 1675 1680
Val Pro Cys Glu Gly Pro Pro Gly Ser Glu Pro Pro Arg Arg Pro
1685 1690 1695
Pro Pro Ala Pro His Asp Gly Asp Arg Lys Glu Leu Pro Arg Glu
1700 1705 1710
Gln Pro Leu Pro Pro Gly Pro Ile Gly Thr Glu Arg Ser Gln His
1715 1720 1725
Thr Asp Arg Gly Thr Glu Pro Gly Pro Ile Arg Pro Ser His Arg
1730 1735 1740
Pro Gly Pro Pro Val Gln Phe Gly Thr Ser Asp Lys Asp Ser Asp
1745 1750 1755
Leu Arg Leu Val Val Gly Asp Ser Leu Lys Ala Glu Lys Glu Leu
1760 1765 1770
Thr Ala Ser Val Thr Glu Ala Ile Pro Val Ser Arg Asp Trp Glu
1775 1780 1785
Leu Leu Pro Ser Ala Ala Ala Ser Ala Glu Pro Gln Ser Lys Asn
1790 1795 1800
Leu Asp Ser Gly His Cys Val Pro Glu Pro Ser Ser Ser Gly Gln
1805 1810 1815
Arg Leu Tyr Pro Glu Val Phe Tyr Gly Ser Ala Gly Pro Ser Ser
1820 1825 1830
Ser Gln Ile Ser Gly Gly Ala Met Asp Ser Gln Leu His Pro Asn
1835 1840 1845
Ser Gly Gly Phe Arg Pro Gly Thr Pro Ser Leu His Pro Tyr Arg
1850 1855 1860
Ser Gln Pro Leu Tyr Leu Pro Pro Gly Pro Ala Pro Pro Ser Ala
1865 1870 1875
Leu Leu Ser Gly Val Ala Leu Lys Gly Gln Phe Leu Asp Phe Ser
1880 1885 1890
Thr Met Gln Ala Thr Glu Leu Gly Lys Leu Pro Ala Gly Gly Val
1895 1900 1905
Leu Tyr Pro Pro Pro Ser Phe Leu Tyr Ser Pro Ala Phe Cys Pro
1910 1915 1920
Ser Pro Leu Pro Asp Thr Ser Leu Leu Gln Val Arg Gln Asp Leu
1925 1930 1935
Pro Ser Pro Ser Asp Phe Tyr Ser Thr Pro Leu Gln Pro Gly Gly
1940 1945 1950
Gln Ser Gly Phe Leu Pro Ser Gly Ala Pro Ala Gln Gln Met Leu
1955 1960 1965
Leu Pro Met Val Asp Ser Gln Leu Pro Val Val Asn Phe Gly Ser
1970 1975 1980
Leu Pro Pro Ala Pro Pro Pro Ala Pro Pro Pro Leu Ser Leu Leu
1985 1990 1995
Pro Val Gly Pro Ala Leu Gln Pro Pro Ser Leu Ala Val Arg Pro
2000 2005 2010
Pro Pro Ala Pro Ala Thr Arg Val Leu Pro Ser Pro Ala Arg Pro
2015 2020 2025
Phe Pro Ala Ser Leu Gly Arg Ala Glu Leu His Pro Val Glu Leu
2030 2035 2040
Lys Pro Phe Gln Asp Tyr Gln Lys Leu Ser Ser Asn Leu Gly Gly
2045 2050 2055
Pro Gly Ser Ser Arg Thr Pro Pro Thr Gly Arg Ser Phe Ser Gly
2060 2065 2070
Leu Asn Ser Arg Leu Lys Ala Thr Pro Ser Thr Tyr Ser Gly Val
2075 2080 2085
Phe Arg Thr Gln Arg Val Asp Leu Tyr Gln Gln Ala Ser Pro Pro
2090 2095 2100
Asp Ala Leu Arg Trp Ile Pro Lys Pro Trp Glu Arg Thr Gly Leu
2105 2110 2115
Pro Pro Arg Glu Gly Pro Ser Arg Arg Ala Glu Glu Pro Gly Ser
2120 2125 2130
Arg Gly Asp Lys Glu Pro Gly Leu Pro Pro Pro Arg
2135 2140 2145
<210>110
<211>535
<212>PRT
<213>人
<400>110
Met Ser Glu Gly Glu Ser Gln Thr Val Leu Ser Ser Gly Ser Asp Pro
1 5 10 15
Lys Val Glu Ser Ser Ser Ser Ala Pro Gly Leu Thr Ser Val Ser Pro
20 25 30
Pro Val Thr Ser Thr Thr Ser Ala Ala Ser Pro Glu Glu Glu Glu Glu
35 40 45
Ser Glu Asp Glu Ser Glu Ile Leu Glu Glu Ser Pro Cys Gly Arg Trp
50 55 60
Gln Lys Arg Arg Glu Glu Val Asn Gln Arg Asn Val Pro Gly Ile Asp
65 70 75 80
Ser Ala Tyr Leu Ala Met Asp Thr Glu Glu Gly Val Glu Val Val Trp
85 90 95
Asn Glu Val Gln Phe Ser Glu Arg Lys Asn Tyr Lys Leu Gln Glu Glu
100 105 110
Lys Val Arg Ala Val Phe Asp Asn Leu Ile Gln Leu Glu His Leu Asn
115 120 125
Ile Val Lys Phe His Lys Tyr Trp Ala Asp Ile Lys Glu Asn Lys Ala
130 135 140
Arg Val Ile Phe Ile Thr Glu Tyr Met Ser Ser Gly Ser Leu Lys Gln
145 150 155 160
Phe Leu Lys Lys Thr Lys Lys Asn His Lys Thr Met Asn Glu Lys Ala
165 170 175
Trp Lys Arg Trp Cys Thr Gln Ile Leu Ser Ala Leu Ser Tyr Leu His
180 185 190
Ser Cys Asp Pro Pro Ile Ile His Gly Asn Leu Thr Cys Asp Thr Ile
195 200 205
Phe Ile Gln His Asn Gly Leu Ile Lys Ile Gly Ser Val Ala Pro Asp
210 215 220
Thr Ile Asn Asn His Val Lys Thr Cys Arg Glu Glu Gln Lys Asn Leu
225 230 235 240
His Phe Phe Ala Pro Glu Tyr Gly Glu Val Thr Asn Val Thr Thr Ala
245 250 255
Val Asp Ile Tyr Ser Phe Gly Met Cys Ala Leu Glu Met Ala Val Leu
260 265 270
Glu Ile Gln Gly Asn Gly Glu Ser Ser Tyr Val Pro Gln Glu Ala Ile
275 280 285
Ser Ser Ala Ile Gln Leu Leu Glu Asp Pro Leu Gln Arg Glu Phe Ile
290 295 300
Gln Lys Cys Leu Gln Ser Glu Pro Ala Arg Arg Pro Thr Ala Arg Glu
305 310 315 320
Leu Leu Phe His Pro Ala Leu Phe Glu Val Pro Ser Leu Lys Leu Leu
325 330 335
Ala Ala His Cys Ile Val Gly His Gln His Met Ile Pro Glu Asn Ala
340 345 350
Leu Glu Glu Ile Thr Lys Asn Met Asp Thr Ser Ala Val Leu Ala Glu
355 360 365
Ile Pro Ala Gly Pro Gly Arg Glu Pro Val Gln Thr Leu Tyr Ser Gln
370 375 380
Ser Pro Ala Leu Glu Leu Asp Lys Phe Leu Glu Asp Val Arg Asn Gly
385 390 395 400
Ile Tyr Pro Leu Thr Ala Phe Gly Leu Pro Arg Pro Gln Gln Pro Gln
405 410 415
Gln Glu Glu Val Thr Ser Pro Val Val Pro Pro Ser Val Lys Thr Pro
420 425 430
Thr Pro Glu Pro Ala Glu Val Glu Thr Arg Lys Val Val Leu Met Gln
435 440 445
Cys Asn Ile Glu Ser Val Glu Glu Gly Val Lys His His Leu Thr Leu
450 455 460
Leu Leu Lys Leu Glu Asp Lys Leu Asn Arg His Leu Ser Cys Asp Leu
465 470 475 480
Met Pro Asn Glu Asn Ile Pro Glu Leu Ala Ala Glu Leu Val Gln Leu
485 490 495
Gly Phe Ile Ser Glu Ala Asp Gln Ser Arg Leu Thr Ser Leu Leu Glu
500 505 510
Glu Thr Leu Asn Lys Phe Asn Phe Ala Arg Asn Ser Thr Leu Asn Ser
515 520 525
Ala Ala Val Thr Val Ser Ser
530 535
<210>111
<211>1980
<212>PRT
<213>人
<400>111
Met Asn Pro Thr Asn Pro Phe Ser Gly Gln Gln Pro Ser Ala Phe Ser
1 5 10 15
Ala Ser Ser Ser Asn Val Gly Thr Leu Pro Ser Lys Pro Pro Phe Arg
20 25 30
Phe Gly Gln Pro Ser Leu Phe Gly Gln Asn Ser Thr Leu Ser Gly Lys
35 40 45
Ser Ser Gly Phe Ser Gln Val Ser Ser Phe Pro Ala Ser Ser Gly Val
50 55 60
Ser His Ser Ser Ser Val Gln Thr Leu Gly Phe Thr Gln Thr Ser Ser
65 70 75 80
ValGly Pro Phe Ser Gly Leu Glu His Thr Ser Thr Phe Val Ala Thr
85 90 95
Ser Gly Pro Ser Ser Ser Ser Val Leu Gly Asn Thr Gly Phe Ser Phe
100 105 110
Lys Ser Pro Thr Ser Val Gly Ala Phe Pro Ser Thr Ser Ala Phe Gly
115 120 125
Gln Glu Ala Gly Glu Ile Val Asn Ser Gly Phe Gly Lys Thr Glu Phe
130 135 140
Ser Phe Lys Pro Leu Glu Asn Ala Val Phe Lys Pro Ile Leu Gly Ala
145 150 155 160
Glu Ser Glu Pro Glu Lys Thr Gln Ser Gln Ile Ala Ser Gly Phe Phe
165 170 175
Thr Phe Ser His Pro Ile Ser Ser Ala Pro Gly Gly Leu Ala Pro Phe
180 185 190
Ser Phe Pro Gln Val Thr Ser Ser Ser Ala Thr Thr Ser Asn Phe Thr
195 200 205
Phe Ser Lys Pro Val Ser Ser Asn Asn Ser Leu Ser Ala Phe Thr Pro
210 215 220
Ala Leu Ser Asn Gln Asn Val Glu Glu Glu Lys Arg Gly Pro Lys Ser
225 230 235 240
Ile Phe Gly Ser Ser Asn Asn Ser Phe Ser Ser Phe Pro Val Ser Ser
245 250 255
Ala Val Leu Gly Glu Pro Phe Gln Ala Ser Lys Ala Gly Val Arg Gln
260 265 270
Gly Cys Glu Glu Ala Val Ser Gln Val Glu Pro Leu Pro Ser Leu Met
275 280 285
Lys Gly Leu Lys Arg Lys Glu Asp Gln Asp Arg Ser Pro Arg Arg His
290 295 300
Gly His Glu Pro Ala Glu Asp Ser Asp Pro Leu Ser Arg Gly Asp His
305 310 315 320
Pro Pro Asp Lys Arg Pro Val Arg Leu Asn Arg Pro Arg Gly Gly Thr
325 330 335
Leu Phe Gly Arg Thr Ile Gln Asp Val Phe Lys Ser Asn Lys Glu Val
340 345 350
Gly Arg Leu Gly Asn Lys Glu Ala Lys Lys Glu Thr Gly Phe Val Glu
355 360 365
Ser Ala Glu Ser Asp His Met Ala Ile Pro Gly Gly Asn Gln Ser Val
370 375 380
Leu Ala Pro Ser Arg Ile Pro Gly Val Asn Lys Glu Glu Glu Thr Glu
385 390 395 400
Ser Arg Glu Lys Lys Glu Asp Ser Leu Arg Gly Thr Pro Ala Arg Gln
405 410 415
Ser Asn Arg Ser Glu Ser Thr Asp Ser Leu Gly Gly Leu Ser Pro Ser
420 425 430
Glu Val Thr Ala Ile Gln Cys Lys Asn Ile Pro Asp Tyr Leu Asn Asp
435 440 445
Arg Thr Ile Leu Glu Asn His Phe Gly Lys Ile Ala Lys Val Gln Arg
450 455 460
Ile Phe Thr Arg Arg Ser Lys Lys Leu Ala Val Val His Phe Phe Asp
465 470 475 480
His Ala Ser Ala Ala Leu Ala Arg Lys Lys Gly Lys Ser Leu His Lys
485 490 495
Asp Met Ala Ile Phe Trp His Arg Lys Lys Ile Ser Pro Asn Lys Lys
500 505 510
Pro Phe Ser Leu Lys Glu Lys Lys Pro Gly Asp Gly Glu Val Ser Pro
515 520 525
Ser Thr Glu Asp Ala Pro Phe Gln His Ser Pro Leu Gly Lys Ala Ala
530 535 540
Gly Arg Thr Gly Ala Ser Ser Leu Leu Asn Lys Ser Ser Pro Val Lys
545 550 555 560
Lys Pro Ser Leu Leu Lys Ala His Gln Phe Glu Gly Asp Ser Phe Asp
565 570 575
Ser Ala Ser Glu Gly Ser Glu Gly Leu Gly Pro Cys Val Leu Ser Leu
580 585 590
Ser Thr Leu Ile Gly Thr Val Ala Glu Thr Ser Lys Glu Lys Tyr Arg
595 600 605
Leu Leu Asp Gln Arg Asp Arg Ile Met Arg Gln Ala Arg Val Lys Arg
610 615 620
Thr Asp Leu Asp Lys Ala Arg Thr Phe Val Gly Thr Cys Leu Asp Met
625 630 635 640
Cys Pro Glu Lys Glu Arg Tyr Met Arg Glu Thr Arg Ser Gln Leu Ser
645 650 655
Val Phe Glu Val Val Pro Gly Thr Asp Gln Val Asp His Ala Ala Ala
660 665 670
Val Lys Glu Tyr Ser Arg Ser Ser Ala Asp Gln Glu Glu Pro Leu Pro
675 680 685
His Glu Leu Arg Pro Leu Pro Val Leu Ser Arg Thr Met Asp Tyr Leu
690 695 700
Val Thr Gln Ile Met Asp Gln Lys Glu Gly Ser Leu Arg Asp Trp Tyr
705 710 715 720
Asp Phe Val Trp Asn Arg Thr Arg Gly Ile Arg Lys Asp Ile Thr Gln
725 730 735
Gln His Leu Cys Asp Pro Leu Thr Val Ser Leu Ile Glu Lys Cys Thr
740 745 750
Arg Phe His Ile His Cys Ala His Phe Met Cys Glu Glu Pro Met Ser
755 760 765
Ser Phe Asp Ala Lys Ile Asn Asn Glu Asn Met Thr Lys Cys Leu Gln
770 775 780
Ser Leu Lys Glu Met Tyr Gln Asp Leu Arg Asn Lys Gly Val Phe Cys
785 790 795 800
Ala Ser Glu Ala Glu Phe Gln Gly Tyr Asn Val Leu Leu Ser Leu Asn
805 810 815
Lys Gly Asp Ile Leu Arg Glu Val Gln Gln Phe His Pro Ala Val Arg
820 825 830
Asn Ser Ser Glu Val Lys Phe Ala Val Gln Ala Phe Ala Ala Leu Asn
835 840 845
Ser Asn Asn Phe Val Arg Phe Phe Lys Leu Val Gln Ser Ala Ser Tyr
850 855 860
Leu Asn Ala Cys Leu Leu His Cys Tyr Phe Ser Gln Ile Arg Lys Asp
865 870 875 880
Ala Leu Arg Ala Leu Asn Phe Ala Tyr Thr Val Ser Thr Gln Arg Ser
885 890 895
Thr Ile Phe Pro Leu Asp Gly Val Val Arg Met Leu Leu Phe Arg Asp
900 905 910
Cys Glu Glu Ala Thr Asp Phe Leu Thr Cys His Gly Leu Thr Val Ser
915 920 925
Asp Gly Cys Val Glu Leu Asn Arg Ser Ala Phe Leu Glu Pro Glu Gly
930 935 940
Leu Ser Lys Thr Arg Lys Ser Val Phe Ile Thr Arg Lys Leu Thr Val
945 950 955 960
Ser Val Gly Glu Ile Val Asn Gly Gly Pro Leu Pro Pro Val Pro Arg
965 970 975
His Thr Pro Val Cys Ser Phe Asn Ser Gln Asn Lys Tyr Ile Gly Glu
980 985 990
Ser Leu Ala Ala Glu Leu Pro Val Ser Thr Gln Arg Pro Gly Ser Asp
995 1000 1005
Thr Val Gly Gly Gly Arg Gly Glu Glu Cys Gly Val Glu Pro Asp
1010 1015 1020
Ala Pro Leu Ser Ser Leu Pro Gln Ser Leu Pro Ala Pro Ala Pro
1025 1030 1035
Ser Pro Val Pro Leu Pro Pro Val Leu Ala Leu Thr Pro Ser Val
1040 1045 1050
Ala Pro Ser Leu Phe Gln Leu Ser Val Gln Pro Glu Pro Pro Pro
1055 1060 1065
Pro Glu Pro Val Pro Met Tyr Ser Asp Glu Asp Leu Ala Gln Val
1070 1075 1080
Val Asp Glu Leu Ile Gln Glu Ala Leu Gln Arg Asp Cys Glu Glu
1085 1090 1095
Val Gly Ser Ala Gly Ala Ala Tyr Ala Ala Ala Ala Leu Gly Val
1100 1105 1110
Ser Asn Ala Ala Met Glu Asp Leu Leu Thr Ala Ala Thr Thr Gly
1115 1120 1125
Ile Leu Arg His Ile Ala Ala Glu Glu Val Ser Lys Glu Arg Glu
1130 1135 1140
Arg Arg Glu Gln Glu Arg Gln Arg Ala Glu Glu Glu Arg Leu Lys
1145 1150 1155
Gln Glu Arg Glu Leu Val Leu Ser Glu Leu Ser Gln Gly Leu Ala
1160 1165 1170
Val Glu Leu Met Glu Arg Val Met Met Glu Phe Val Arg Glu Thr
1175 1180 1185
Cys Ser Gln Glu Leu Lys Asn Ala Val Glu Thr Asp Gln Arg Val
1190 1195 1200
Arg Val Ala Arg Cys Cys Glu Asp Val Cys Ala His Leu Val Asp
1205 1210 1215
Leu Phe Leu Val Glu Glu Ile Phe Gln Thr Ala Lys Glu Thr Leu
1220 1225 1230
Gln Glu Leu Gln Cys Phe Cys Lys Tyr Leu Gln Arg Trp Arg Glu
1235 1240 1245
Ala Val Thr Ala Arg Lys Lys Leu Arg Arg Gln Met Arg Ala Phe
1250 1255 1260
Pro Ala Ala Pro Cys Cys Val Asp Val Ser Asp Arg Leu Arg Ala
1265 1270 1275
Leu Ala Pro Ser Ala Glu Cys Pro Ile Ala Glu Glu Asn Leu Ala
1280 1285 1290
Arg Gly Leu Leu Asp Leu Gly His Ala Gly Arg Leu Gly Ile Ser
1295 1300 1305
Cys Thr Arg Leu Arg Arg Leu Arg Asn Lys Thr Ala His Gln Met
1310 1315 1320
Lys Val Gln His Phe Tyr Gln Gln Leu Leu Ser Asp Val Ala Trp
1325 1330 1335
Ala Ser Leu Asp Leu Pro Ser Leu Val Ala Glu His Leu Pro Gly
1340 1345 1350
Arg Gln Glu His Val Phe Trp Lys Leu Val Leu Val Leu Pro Asp
1355 1360 1365
Val Glu Glu Gln Ser Pro Glu Ser Cys Gly Arg Ile Leu Ala Asn
1370 1375 1380
Trp Leu Lys Val Lys Phe Met Gly Asp Glu Gly Ser Val Asp Asp
1385 1390 1395
Thr Ser Ser Asp Ala Gly Gly Ile Gln Thr Leu Ser Leu Phe Asn
1400 1405 1410
Ser Leu Ser Ser Lys Gly Asp Gln Met Ile Ser Val Asn Val Cys
1415 1420 1425
Ile Lys Val Ala His Gly Ala Leu Ser Asp Gly Ala Ile Asp Ala
1430 1435 1440
Val Glu Thr Gln Lys Asp Leu Leu Gly Ala Ser Gly Leu Met Leu
1445 1450 1455
Leu Leu Pro Pro Lys Met Lys Ser Glu Asp Met Ala Glu Glu Asp
1460 1465 1470
Val Tyr Trp Leu Ser Ala Leu Leu Gln Leu Lys Gln Leu Leu Gln
1475 1480 1485
Ala Lys Pro Phe Gln Pro Ala Leu Pro Leu Val Val Leu Val Pro
1490 1495 1500
Ser Pro Gly Gly Asp Ala Val Glu Lys Glu Val Glu Asp Gly Leu
1505 1510 1515
Met Leu Gln Asp Leu Val Ser Ala Lys Leu Ile Ser Asp Tyr Thr
1520 1525 1530
Val Thr Glu Ile Pro Asp Thr Ile Asn Asp Leu Gln Gly Ser Thr
1535 1540 1545
Lys Val Leu Gln Ala Val Gln Trp Leu Val Ser His Cys Pro His
1550 1555 1560
Ser Leu Asp Leu Cys Cys Gln Thr Leu Ile Gln Tyr Val Glu Asp
1565 1570 1575
Gly Ile Gly His Glu Phe Ser Gly Arg Phe Phe His Asp Arg Arg
1580 1585 1590
Glu Arg Arg Leu Gly Gly Leu Ala Ser Gln Glu Pro Gly Ala Ile
1595 1600 1605
Ile Glu Leu Phe Asn Ser Val Leu Gln Phe Leu Ala Ser Val Val
1610 1615 1620
Ser Ser Glu Gln Leu Cys Asp Leu Ser Trp Pro Val Thr Glu Phe
1625 1630 1635
Ala Glu Ala Gly Gly Ser Arg Leu Leu Pro His Leu His Trp Asn
1640 1645 1650
Ala Pro Glu His Leu Ala Trp Leu Lys Gln Ala Val Leu Gly Phe
1655 1660 1665
Gln Leu Pro Gln Met Asp Leu Pro Pro Leu Gly Ala Pro Trp Leu
1670 1675 1680
Pro Val Cys Ser Met Val Val Gln Tyr Ala Ser Gln Ile Pro Ser
1685 1690 1695
Ser Arg Gln Thr Gln Pro Val Leu Gln Ser Gln Val Glu Asn Leu
1700 1705 1710
Leu His Arg Thr Tyr Cys Arg Trp Lys Ser Lys Ser Pro Ser Pro
1715 1720 1725
Val His Gly Ala Gly Pro Ser Val Met Glu Ile Pro Trp Asp Asp
1730 1735 1740
Leu Ile Ala Leu Cys Ile Asn His Lys Leu Arg Asp Trp Thr Pro
1745 1750 1755
Pro Arg Leu Pro Val Thr Ser Glu Ala Leu Ser Glu Asp Gly Gln
1760 1765 1770
Ile Cys Val Tyr Phe Phe Lys Asn Asp Leu Lys Lys Tyr Asp Val
1775 1780 1785
Pro Leu Ser Trp Glu Gln Ala Arg Leu Gln Thr Gln Lys Glu Leu
1790 1795 1800
Gln Leu Arg Glu Gly Arg Leu Ala Ile Lys Pro Phe His Pro Ser
1805 1810 1815
Ala Asn Asn Phe Pro Ile Pro Leu Leu His Met His Arg Asn Trp
1820 1825 1830
Lys Arg Ser Thr Glu Cys Ala Gln Glu Gly Arg Ile Pro Ser Thr
1835 1840 1845
Glu Asp Leu Met Arg Gly Ala Ser Ala Glu Glu Leu Leu Ala Gln
1850 1855 1860
Cys Leu Ser Ser Ser Leu Leu Leu Glu Lys Glu Glu Asn Lys Arg
1865 1870 1875
Phe Glu Asp Gln Leu Gln Gln Trp Leu Ser Glu Asp Ser Gly Ala
1880 1885 1890
Phe Thr Asp Leu Thr Ser Leu Pro Leu Tyr Leu Pro Gln Thr Leu
1895 1900 1905
Val Ser Leu Ser His Thr Ile Glu Pro Val Met Lys Thr Ser Val
1910 1915 1920
Thr Thr Ser Pro Gln Ser Asp Met Met Arg Glu Gln Leu Gln Leu
1925 1930 1935
Ser Glu Ala Thr Gly Thr Cys Leu Gly Glu Arg Leu Lys His Leu
1940 1945 1950
Glu Arg Leu Ile Arg Ser Ser Arg Glu Glu Glu Val Ala Ser Glu
1955 1960 1965
Leu His Leu Ser Ala Leu Leu Asp Met Val Asp Ile
1970 1975 1980
<210>112
<211>1669
<212>PRT
<213>人
<400>112
Met Gly Pro Arg Leu Ser Val Trp Leu Leu Leu Leu Pro Ala Ala Leu
1 5 10 15
Leu Leu His Glu Glu His Ser Arg Ala Ala Ala Lys Gly Gly Cys Ala
20 25 30
Gly Ser Gly Cys Gly Lys Cys Asp Cys His Gly Val Lys Gly Gln Lys
35 40 45
Gly Glu Arg Gly Leu Pro Gly Leu Gln Gly Val Ile Gly Phe Pro Gly
50 55 60
Met Gln Gly Pro Glu Gly Pro Gln Gly Pro Pro Gly Gln Lys Gly Asp
65 70 75 80
Thr Gly Glu Pro Gly Leu Pro Gly Thr Lys Gly Thr Arg Gly Pro Pro
85 90 95
Gly Ala Ser Gly Tyr Pro Gly Asn Pro Gly Leu Pro Gly Ile Pro Gly
100 105 110
Gln Asp Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly Cys Asn Gly Thr
115 120 125
Lys Gly Glu Arg Gly Pro Leu Gly Pro Pro Gly Leu Pro Gly Phe Ala
130 135 140
Gly Asn Pro Gly Pro Pro Gly Leu Pro Gly Met Lys Gly Asp Pro Gly
145 150 155 160
Glu Ile Leu Gly His Val Pro Gly Met Leu Leu Lys Gly Glu Arg Gly
165 170 175
Phe Pro Gly Ile Pro Gly Thr Pro Gly Pro Pro Gly Leu Pro Gly Leu
180 185 190
Gln Gly Pro Val Gly Pro Pro Gly Phe Thr Gly Pro Pro Gly Pro Pro
195 200 205
Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Gln Met Gly Leu Ser Phe
210 215 220
Gln Gly Pro Lys Gly Asp Lys Gly Asp Gln Gly Val Ser Gly Pro Pro
225 230 235 240
Gly Val Pro Gly Gln Ala Gln Val Gln Glu Lys Gly Asp Phe Ala Thr
245 250 255
Lys Gly Glu Lys Gly Gln Lys Gly Glu Pro Gly Phe Gln Gly Met Pro
260 265 270
Gly Val Gly Glu Lys Gly Glu Pro Gly Lys Pro Gly Pro Arg Gly Lys
275 280 285
Pro Gly Lys Asp Gly Asp Lys Gly Glu Lys Gly Ser Pro Gly Phe Pro
290 295 300
Gly Glu Pro Gly Tyr Pro Gly Leu Ile Gly Arg Gln Gly Pro Gln Gly
305 310 315 320
Glu Lys Gly Glu Ala Gly Pro Pro Gly Pro Pro Gly Ile Val Ile Gly
325 330 335
Thr Gly Pro Leu Gly Glu Lys Gly Glu Arg Gly Tyr Pro Gly Thr Pro
340 345 350
Gly Pro Arg Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Leu Pro Gly
355 360 365
Gln Pro Gly Pro Pro Gly Leu Pro Val Pro Gly Gln Ala Gly Ala Pro
370 375 380
Gly Phe Pro Gly Glu Arg Gly Glu Lys Gly Asp Arg Gly Phe Pro Gly
385 390 395 400
Thr Ser Leu Pro Gly Pro Ser Gly Arg Asp Gly Leu Pro Gly Pro Pro
405 410 415
Gly Ser Pro Gly Pro Pro Gly Gln Pro Gly Tyr Thr Asn Gly Ile Val
420 425 430
Glu Cys Gln Pro Gly Pro Pro Gly Asp Gln Gly Pro Pro Gly Ile Pro
435 440 445
Gly Gln Pro Gly Phe Ile Gly Glu Ile Gly Glu Lys Gly Gln Lys Gly
450 455 460
Glu Ser Cys Leu Ile Cys Asp Ile Asp Gly Tyr Arg Gly Pro Pro Gly
465 470 475 480
Pro Gln Gly Pro Pro Gly Glu Ile Gly Phe Pro Gly Gln Pro Gly Ala
485 490 495
Lys Gly Asp Arg Gly Leu Pro Gly Arg Asp Gly Val Ala Gly Val Pro
500 505 510
Gly Pro Gln Gly Thr Pro Gly Leu Ile Gly Gln Pro Gly Ala Lys Gly
515 520 525
Glu Pro Gly Glu Phe Tyr Phe Asp Leu Arg Leu Lys Gly Asp Lys Gly
530 535 540
Asp Pro Gly Phe Pro Gly Gln Pro Gly Met Pro Gly Arg Ala Gly Ser
545 550 555 560
Pro Gly Arg Asp Gly His Pro Gly Leu Pro Gly Pro Lys Gly Ser Pro
565 570 575
Gly Ser Val Gly Leu Lys Gly Glu Arg Gly Pro Pro Gly Gly Val Gly
580 585 590
Phe Pro Gly Ser Arg Gly Asp Thr Gly Pro Pro Gly Pro Pro Gly Tyr
595 600 605
Gly Pro Ala Gly Pro Ile Gly Asp Lys Gly Gln Ala Gly Phe Pro Gly
610 615 620
Gly Pro Gly Ser Pro Gly Leu Pro Gly Pro Lys Gly Glu Pro Gly Lys
625 630 635 640
Ile Val Pro Leu Pro Gly Pro Pro Gly Ala Glu Gly Leu Pro Gly Ser
645 650 655
Pro Gly Phe Pro Gly Pro Gln Gly Asp Arg Gly Phe Pro Gly Thr Pro
660 665 670
Gly Arg Pro Gly Leu Pro Gly Glu Lys Gly Ala Val Gly Gln Pro Gly
675 680 685
Ile Gly Phe Pro Gly Pro Pro Gly Pro Lys Gly Val Asp Gly Leu Pro
690 695 700
Gly Asp Met Gly Pro Pro Gly Thr Pro Gly Arg Pro Gly Phe Asn Gly
705 710 715 720
Leu Pro Gly Asn Pro Gly Val Gln Gly Gln Lys Gly Glu Pro Gly Val
725 730 735
Gly Leu Pro Gly Leu Lys Gly Leu Pro Gly Leu Pro Gly Ile Pro Gly
740 745 750
Thr Pro Gly Glu Lys Gly Ser Ile Gly Val Pro Gly Val Pro Gly Glu
755 760 765
His Gly Ala Ile Gly Pro Pro Gly Leu Gln Gly Ile Arg Gly Glu Pro
770 775 780
Gly Pro Pro Gly Leu Pro Gly Ser Val Gly Ser Pro Gly Val Pro Gly
785 790 795 800
Ile Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Gly Gln Gly Pro Pro
805 810 815
Gly Leu Ser Gly Pro Pro Gly Ile Lys Gly Glu Lys Gly Phe Pro Gly
820 825 830
Phe Pro Gly Leu Asp Met Pro Gly Pro Lys Gly Asp Lys Gly Ala Gln
835 840 845
Gly Leu Pro Gly Ile Thr Gly Gln Ser Gly Leu Pro Gly Leu Pro Gly
850 855 860
Gln Gln Gly Ala Pro Gly Ile Pro Gly Phe Pro Gly Ser Lys Gly Glu
865 870 875 880
Met Gly Val Met Gly Thr Pro Gly Gln Pro Gly Ser Pro Gly Pro Val
885 890 895
Gly Ala Pro Gly Leu Pro Gly Glu Lys Gly Asp His Gly Phe Pro Gly
900 905 910
Ser Ser Gly Pro Arg Gly Asp Pro Gly Leu Lys Gly Asp Lys Gly Asp
915 920 925
Val Gly Leu Pro Gly Lys Pro Gly Ser Met Asp Lys Val Asp Met Gly
930 935 940
Ser Met Lys Gly Gln Lys Gly Asp Gln Gly Glu Lys Gly Gln Ile Gly
945 950 955 960
Pro Ile Gly Glu Lys Gly Ser Arg Gly Asp Pro Gly Thr Pro Gly Val
965 970 975
Pro Gly Lys Asp Gly Gln Ala Gly Gln Pro Gly Gln Pro Gly Pro Lys
980 985 990
Gly Asp Pro Gly Ile Ser Gly Thr Pro Gly Ala Pro Gly Leu Pro Gly
995 1000 1005
Pro Lys Gly Ser Val Gly Gly Met Gly Leu Pro Gly Thr Pro Gly
1010 1015 1020
Glu Lys Gly Val Pro Gly Ile Pro Gly Pro Gln Gly Ser Pro Gly
1025 1030 1035
Leu Pro Gly Asp Lys Gly Ala Lys Gly Glu Lys Gly Gln Ala Gly
1040 1045 1050
Pro Pro Gly Ile Gly Ile Pro Gly Leu Arg Gly Glu Lys Gly Asp
1055 1060 1065
Gln Gly Ile Ala Gly Phe Pro Gly Ser Pro Gly Glu Lys Gly Glu
1070 1075 1080
Lys Gly Ser Ile Gly Ile Pro Gly Met Pro Gly Ser Pro Gly Leu
1085 1090 1095
Lys Gly Ser Pro Gly Ser Val Gly Tyr Pro Gly Ser Pro Gly Leu
1100 1105 1110
Pro Gly Glu Lys Gly Asp Lys Gly Leu Pro Gly Leu Asp Gly Ile
1115 1120 1125
Pro Gly Val Lys Gly Glu Ala Gly Leu Pro Gly Thr Pro Gly Pro
1130 1135 1140
Thr Gly Pro Ala Gly Gln Lys Gly Glu Pro Gly Ser Asp Gly Ile
1145 1150 1155
Pro Gly Ser Ala Gly Glu Lys Gly Glu Pro Gly Leu Pro Gly Arg
1160 1165 1170
Gly Phe Pro Gly Phe Pro Gly Ala Lys Gly Asp Lys Gly Ser Lys
1175 1180 1185
Gly Glu Val Gly Phe Pro Gly Leu Ala Gly Ser Pro Gly Ile Pro
1190 1195 1200
Gly Ser Lys Gly Glu Gln Gly Phe Met Gly Pro Pro Gly Pro Gln
1205 1210 1215
Gly Gln Pro Gly Leu Pro Gly Ser Pro Gly His Ala Thr Glu Gly
1220 1225 1230
Pro Lys Gly Asp Arg Gly Pro Gln Gly Gln Pro Gly Leu Pro Gly
1235 1240 1245
Leu Pro Gly Pro Met Gly Pro Pro Gly Leu Pro Gly Ile Asp Gly
1250 1255 1260
Val Lys Gly Asp Lys Gly Asn Pro Gly Trp Pro Gly Ala Pro Gly
1265 1270 1275
Val Pro Gly Pro Lys Gly Asp Pro Gly Phe Gln Gly Met Pro Gly
1280 1285 1290
Ile Gly Gly Ser Pro Gly Ile Thr Gly Ser Lys Gly Asp Met Gly
1295 1300 1305
Pro Pro Gly Val Pro Gly Phe Gln Gly Pro Lys Gly Leu Pro Gly
1310 1315 1320
Leu Gln Gly Ile Lys Gly Asp Gln Gly Asp Gln Gly Val Pro Gly
1325 1330 1335
Ala Lys Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Tyr Asp
1340 1345 1350
Ile Ile Lys Gly Glu Pro Gly Leu Pro Gly Pro Glu Gly Pro Pro
1355 1360 1365
Gly Leu Lys Gly Leu Gln Gly Leu Pro Gly Pro Lys Gly Gln Gln
1370 1375 1380
Gly Val Thr Gly Leu Val Gly Ile Pro Gly Pro Pro Gly Ile Pro
1385 1390 1395
Gly Phe Asp Gly Ala Pro Gly Gln Lys Gly Glu Met Gly Pro Ala
1400 1405 1410
Gly Pro Thr Gly Pro Arg Gly Phe Pro Gly Pro Pro Gly Pro Asp
1415 1420 1425
Gly Leu Pro Gly Ser Met Gly Pro Pro Gly Thr Pro Ser Val Asp
1430 1435 1440
His Gly Phe Leu Val Thr Arg His Ser Gln Thr Ile Asp Asp Pro
1445 1450 1455
Gln Cys Pro Ser Gly Thr Lys Ile Leu Tyr His Gly Tyr Ser Leu
1460 1465 1470
Leu Tyr Val Gln Gly Asn Glu Arg Ala His Gly Gln Asp Leu Gly
1475 1480 1485
Thr Ala Gly Ser Cys Leu Arg Lys Phe Ser Thr Met Pro Phe Leu
1490 1495 1500
Phe Cys Asn Ile Asn Asn Val Cys Asn Phe Ala Ser Arg Asn Asp
1505 1510 1515
Tyr Ser Tyr Trp Leu Ser Thr Pro Glu Pro Met Pro Met Ser Met
1520 1525 1530
Ala Pro Ile Thr Gly Glu Asn Ile Arg Pro Phe Ile Ser Arg Cys
1535 1540 1545
Ala Val Cys Glu Ala Pro Ala Met Val Met Ala Val His Ser Gln
1550 1555 1560
Thr Ile Gln Ile Pro Pro Cys Pro Ser Gly Trp Ser Ser Leu Trp
1565 1570 1575
Ile Gly Tyr Ser Phe Val Met His Thr Ser Ala Gly Ala Glu Gly
1580 1585 1590
Ser Gly Gln Ala Leu Ala Ser Pro Gly Ser Cys Leu Glu Glu Phe
1595 1600 1605
Arg Ser Ala Pro Phe Ile Glu Cys His Gly Arg Gly Thr Cys Asn
1610 1615 1620
Tyr Tyr Ala Asn Ala Tyr Ser Phe Trp Leu Ala Thr Ile Glu Arg
1625 1630 1635
Ser Glu Met Phe Lys Lys Pro Thr Pro Ser Thr Leu Lys Ala Gly
1640 1645 1650
Glu Leu Arg Thr His Val Ser Arg Cys Gln Val Cys Met Arg Arg
1655 1660 1665
Thr
<210>113
<211>465
<212>PRT
<213>人
<400>113
Met Val Ser Ser Gln Lys Leu Glu Lys Pro Ile Glu Met Gly Ser Ser
1 5 10 15
Glu Pro Leu Pro Ile Ala Asp Gly Asp Arg Arg Arg Lys Lys Lys Arg
20 25 30
Arg Gly Arg Ala Thr Asp Ser Leu Pro Gly Lys Phe Glu Asp Met Tyr
35 40 45
Lys Leu Thr Ser Glu Leu Leu Gly Glu Gly Ala Tyr Ala Lys Val Gln
50 55 60
Gly Ala Val Ser Leu Gln Asn Gly Lys Glu Tyr Ala Val Lys Ile Ile
65 70 75 80
Glu Lys Gln Ala Gly His Ser Arg Ser Arg Val Phe Arg Glu Val Glu
85 90 95
Thr Leu Tyr Gln Cys Gln Gly Asn Lys Asn Ile Leu Glu Leu Ile Glu
100 105 110
Phe Phe Glu Asp Asp Thr Arg Phe Tyr Leu Val Phe Glu Lys Leu Gln
115 120 125
Gly Gly Ser Ile Leu Ala His Ile Gln Lys Gln Lys His Phe Asn Glu
130 135 140
Arg Glu Ala Ser Arg Val ValArg Asp Val Ala Ala Ala Leu Asp Phe
145 150 155 160
Leu His Thr Lys Asp Lys Val Ser Leu Cys His Leu Gly Trp Ser Ala
165 170 175
Met Ala Pro Ser Gly Leu Thr Ala Ala Pro Thr Ser Leu Gly Ser Ser
180 185 190
Asp Pro Pro Thr Ser Ala Ser Gln Val Ala Gly Thr Thr Gly Ile Ala
195 200 205
His Arg Asp Leu Lys Pro Glu Asn Ile Leu Cys Glu Ser Pro Glu Lys
210 215 220
Val Ser Pro Val Lys Ile Cys Asp Phe Asp Leu Gly Ser Gly Met Lys
225 230 235 240
Leu Asn Asn Ser Cys Thr Pro Ile Thr Thr Pro Glu Leu Thr Thr Pro
245 250 255
Cys Gly Ser Ala Glu Tyr Met Ala Pro Glu Val Val Glu Val Phe Thr
260 265 270
Asp Gln Ala Thr Phe Tyr Asp Lys Arg Cys Asp Leu Trp Ser Leu Gly
275 280 285
Val Val Leu Tyr Ile Met Leu Ser Gly Tyr Pro Pro Phe Val Gly His
290 295 300
Cys Gly Ala Asp Cys Gly Trp Asp Arg Gly Glu Val Cys Arg Val Cys
305 310 315 320
Gln Asn Lys Leu Phe Glu Ser Ile Gln Glu Gly Lys Tyr Glu Phe Pro
325 330 335
Asp Lys Asp Trp Ala His Ile Ser Ser Glu Ala Lys Asp Leu Ile Ser
340 345 350
Lys Leu Leu Val Arg Asp Ala Lys Gln Arg Leu Ser Ala Ala Gln Val
355 360 365
Leu Gln His Pro Trp Val Gln Gly Gln Ala Pro Glu Lys Gly Leu Pro
370 375 380
Thr Pro Gln Val Leu Gln Arg Asn Ser Ser Thr Met Asp Leu Thr Leu
385 390 395 400
Phe Ala Ala Glu Ala Ile Ala Leu Asn Arg Gln Leu Ser Gln His Glu
405 410 415
Glu Asn Glu Leu Ala Glu Glu Pro Glu Ala Leu Ala Asp Gly Leu Cys
420 425 430
Ser Met Lys Leu Ser Pro Pro Cys Lys Ser Arg Leu Ala Arg Arg Arg
435 440 445
Ala Leu Ala Gln Ala Gly Arg Gly Glu Asp Arg Ser Pro Pro Thr Ala
450 455 460
Leu
465
<210>114
<211>193
<212>PRT
<213>人
<400>114
Met Ala Arg Ala Arg Gln Glu Gly Ser Ser Pro Glu Pro Val Glu Gly
1 5 10 15
Leu Ala Arg Asp Gly Pro Arg Pro Phe Pro Leu Gly Arg Leu Val Pro
20 25 30
Ser Ala Val Ser Cys Gly Leu Cys Glu Pro Gly Leu Ala Ala Ala Pro
35 40 45
Ala Ala Pro Thr Leu Leu Pro Ala Ala Tyr Leu Cys Ala Pro Thr Ala
50 55 60
Pro Pro Ala Val Thr Ala Ala Leu Gly Gly Ser Arg Trp Pro Gly Gly
65 70 75 80
Pro Arg Ser Arg Pro Arg Gly Pro Arg Pro Asp Gly Pro Gln Pro Ser
85 90 95
Leu Ser Leu Ala Glu Gln His Leu Glu Ser Pro Val Pro Ser Ala Pro
100 105 110
Gly Ala Leu Ala Gly Gly Pro Thr Gln Ala Ala Pro Gly Val Arg Gly
115 120 125
Glu Glu Glu Gln Trp Ala Arg Glu Ile Gly Ala Gln Leu Arg Arg Met
130 135 140
Ala Asp Asp Leu Asn Ala Gln Tyr Glu Arg Arg Arg Gln Glu Glu Gln
145 150 155 160
Gln Arg His Arg Pro Ser Pro Trp Arg Val Leu Tyr Asn Leu Ile Met
165 170 175
Gly Leu Leu Pro Leu Pro Arg Gly His Arg Ala Pro Glu Met Glu Pro
180 185 190
Asn
<210>115
<211>897
<212>PRT
<213>人
<400>115
Met Glu Tyr Thr Lys Gln Leu Ile Leu Ser Cys Leu Leu Asn Ile Cys
1 5 10 15
Gln Lys Leu Ser Pro Asp Gly Gly Lys Ile Pro Lys Asp Ile Leu Asp
20 25 30
Glu Glu Lys Phe Asn Val Glu Leu Ile Val Gln Cys Ile Arg Leu Ser
35 40 45
Glu Met Pro Gln Thr His His His Ala Leu Leu Leu Leu Gly Thr Val
50 55 60
Ala Gly Ile Phe Pro Asp Lys Val Leu His Asn Ile Met Ser Ile Phe
65 70 75 80
Thr Phe Met Gly Ala Asn Val Met Arg Leu Asp Asp Thr Tyr Ser Phe
85 90 95
Gln Val Ile Asn Lys Thr Val Lys Met Val Ile Pro Ala Leu Ile Gln
100 105 110
Ser Asp Ser Gly Asp Ser Ile Glu Val Ser Arg Asn Val Glu Glu Ile
115 120 125
Val Val Lys Ile Ile Ser Val Phe Val Asp Ala Leu Pro His Val Pro
130 135 140
Glu His Arg Arg Leu Pro Ile Leu Val Gln Leu Val Asp Thr Leu Gly
145 150 155 160
Ala Glu Lys Phe Leu Trp Ile Leu Leu Ile Leu Leu Phe Glu Gln Tyr
165 170 175
Val Thr Lys Thr Val Leu Ala Ala Ala Tyr Gly Glu Lys Asp Ala Ile
180 185 190
Leu Glu Ala Asp Thr Glu Phe Trp Phe Ser Val Cys Cys Glu Phe Ser
195 200 205
Val Gln His Gln Ile Gln Ser Leu Met Asn Ile Leu Gln Tyr Leu Leu
210 215 220
Lys Leu Pro Glu Glu Lys Glu Glu Thr Ile Pro Lys Ala Val Ser Phe
225 230 235 240
Asn Lys Ser Glu Ser Gln Glu Glu Met Leu Gln Val Phe Asn Val Glu
245 250 255
Thr His Thr Ser Lys Gln Leu Arg His Phe Lys Phe Leu Ser Val Ser
260 265 270
Phe Met Ser Gln Leu Leu Ser Ser Asn Asp Phe Leu Lys Lys Val Val
275 280 285
Glu Ser Gly Gly Pro Glu Ile Leu Lys Gly Leu Glu Glu Arg Leu Leu
290 295 300
Glu Thr Val Leu Gly Tyr Ile Ser Ala Val Ala Gln Ser Met Glu Arg
305 310 315 320
Asn Ala Asp Lys Leu Thr Val Lys Phe Trp Arg Ala Leu Leu Ser Lys
325 330 335
Ala Tyr Asp Leu Leu Asp Lys Val Asn Ala Leu Leu Pro Thr Glu Thr
340 345 350
Phe Ile Pro Val Ile Arg Gly Leu Val Gly Asn Pro Leu Pro Ser Val
355 360 365
Arg Arg Lys Ala Leu Asp Leu Leu Asn Asn Lys Leu Gln Gln Asn Ile
370 375 380
Ser Trp Lys Lys Thr Ile Val Thr Arg Phe Leu Lys Leu Val Pro Asp
385 390 395 400
Leu Leu Ala Ile Val Gln Arg Lys Lys Lys Glu Gly Glu Glu Glu Gln
405 410 415
Ala Ile Asn Arg Gln Thr Ala Leu Tyr Thr Leu Lys Leu Leu Cys Lys
420 425 430
Asn Phe Gly Ala Glu Asn Pro Asp Pro Phe Val Pro Val Leu Ser Thr
435 440 445
Ala Val Lys Leu Ile Ala Pro Glu Arg Lys Glu Glu Lys Asn Val Leu
450 455 460
Gly Ser Ala Leu Leu Cys Ile Ala Glu Val Thr Ser Thr Leu Glu Ala
465 470 475 480
Leu Ala Ile Pro Gln Leu Pro Ser Leu Met Pro Ser Leu Leu Thr Thr
485 490 495
Met Lys Asn Thr Ser Glu Leu Val Ser Ser Glu Val Tyr Leu Leu Ser
500 505 510
Ala Leu Ala Ala Leu Gln Lys Val Val Glu Thr Leu Pro His Phe Ile
515 520 525
Ser Pro Tyr Leu Glu Gly Ile Leu Ser Gln Val Ile His Leu Glu Lys
530 535 540
Ile Thr Ser Glu Met Gly Ser Ala Ser Arg Ala Asn Ile Arg Leu Thr
545 550 555 560
Ser Leu Lys Lys Thr Leu Ala Thr Thr Leu Ala Pro Arg Val Leu Leu
565 570 575
Pro Ala Ile Lys Lys Thr Tyr Lys Gln Ile Glu Lys Asn Trp Lys Asn
580 585 590
His Met Gly Pro Phe Met Ser Ile Leu Gln Glu His Ile Gly Ala Met
595 600 605
Lys Lys Glu Glu Leu Thr Ser His Gln Ser Gln Leu Thr Ala Phe Phe
610 615 620
Leu Glu Ala Leu Asp Phe Arg Ala Gln His Ser Glu Asn Asp Leu Glu
625 630 635 640
Glu Val Gly Lys Thr Glu Asn Cys Ile Ile Asp Cys Leu Val Ala Met
645 650 655
Val Val Lys Leu Ser Glu Val Thr Phe Arg Pro Leu Phe Phe Lys Leu
660 665 670
Phe Asp Trp Ala Lys Thr Glu Asp Ala Pro Lys Asp Arg Leu Leu Thr
675 680 685
Phe Tyr Asn Leu Ala Asp Cys Ile Ala Glu Lys Leu Lys Gly Leu Phe
690 695 700
Thr Leu Phe Ala Gly His Leu Val Lys Pro Phe Ala Asp Thr Leu Asp
705 710 715 720
Gln Val Asn Ile Ser Lys Thr Asp Glu Ala Phe Phe Asp Ser Glu Asn
725 730 735
Asp Pro Glu Lys Cys Cys Leu Leu Leu Gln Phe Ile Leu Asn Cys Leu
740 745 750
Tyr Lys Ile Phe Leu Phe Asp Thr Gln His Phe Ile Ser Lys Glu Arg
755 760 765
Ala Gly Ala Leu Met Met Pro Leu Val Asp Gln Leu Val Asn Arg Leu
770 775 780
Gly Gly Glu Glu Lys Phe Gln Glu Arg Val Thr Lys His Leu Ile Pro
785 790 795 800
Cys Ile Ala Gln Phe Ser Val Ala Met Ala Asp Asp Ser Leu Trp Lys
805 810 815
Pro Leu Asn Tyr Gln Ile Leu Leu Lys Thr Arg Asp Ser Ser Pro Lys
820 825 830
Val Arg Phe Ala Ala Leu Ile Thr Val Leu Ala Leu Ala Glu Lys Leu
835 840 845
Lys Glu Asn TyrIle Val Leu Leu Pro Glu Ser Ile Pro Phe Leu Ala
850 855 860
Glu Leu Met Glu Asp Glu Cys Glu Glu Val Glu His Gln Cys Gln Lys
865 870 875 880
Thr Ile Gln Gln Leu Glu Thr Val Leu Gly Glu Pro Leu Gln Ser Tyr
885 890 895
Phe
<210>116
<211>201
<212>PRT
<213>人
<400>116
Met Asp Leu Ser Leu Leu Trp Val Leu Leu Pro Leu Val Thr Met Ala
1 5 10 15
Trp Gly Gln Tyr Gly Asp Tyr Gly Tyr Pro Tyr Gln Gln Tyr His Asp
20 25 30
Tyr Ser Asp Asp Gly Trp Val Asn Leu Asn Arg Gln Gly Phe Ser Tyr
35 40 45
Gln Cys Pro Gln Gly Gln Val Ile Val Ala Val Arg Ser Ile Phe Ser
50 55 60
Lys Lys Glu Gly Ser Asp Arg Gln Trp Asn Tyr Ala Cys Met Pro Thr
65 70 75 80
Pro Gln Ser Leu Gly Glu Pro Thr Glu Cys Trp Trp Glu Glu Ile Asn
85 90 95
Arg Ala Gly Met Glu Trp Tyr Gln Thr Cys Ser Asn Asn Gly Leu Val
100 105 110
Ala Gly Phe Gln Ser Arg Tyr Phe Glu Ser Val Leu Asp Arg Glu Trp
115 120 125
Gln Phe Tyr Cys Cys Arg Tyr Ser Lys Arg Cys Pro Tyr Ser Cys Trp
130 135 140
Leu Thr Thr Glu Tyr Pro Gly His Tyr Gly Glu Glu Met Asp Met Ile
145 150 155 160
Ser Tyr Asn Tyr Asp Tyr Tyr Ile Arg Gly Ala Thr Thr Thr Phe Ser
165 170 175
Ala Val Glu Arg Asp Arg Gln Trp Lys Phe Ile Met Cys Arg Met Thr
180 185 190
Glu Tyr Asp Cys Glu Phe Ala Asn Val
195 200
<210>117
<211>265
<212>PRT
<213>人
<400>117
Met Pro Met Arg His Arg Lys Lys Ala Ala Asp Lys Asn Leu Pro Cys
1 5 10 15
Arg Pro Leu Val Cys Ala Val Leu Asp Leu Met Val Glu Phe Ile Val
20 25 30
Thr His Met Met Lys Glu Phe Pro Met Asp Leu Tyr Ile Arg Cys Ile
35 40 45
Gln Val Val His Lys Leu Leu Cys Tyr Gln Lys Lys Cys Arg Val Arg
50 55 60
Leu His Tyr Thr Trp Arg Glu Leu Trp Ser Ala Leu Ile Asn Leu Leu
65 70 75 80
Lys Phe Leu Met Ser Asn Glu Thr Val Leu Leu Ala Lys Hi s Asn Ile
85 90 95
Phe Thr Leu Ala Leu Met Ile Val Asn Leu Phe Asn Met Phe Ile Thr
100 105 110
Tyr Gly Asp Thr Phe Leu Pro Thr Pro Ser Ser Tyr Asp Glu Leu Tyr
115 120 125
Tyr Glu Ile Ile Arg Met His Gln Ser Phe Asp Asn Leu Tyr Ser Met
130 135 140
Val Leu Arg Leu Ser Thr Asn Ala Gly Gln Trp Lys Glu Ala Ala Ser
145 150 155 160
Lys Val Thr His Ala Leu Val Asn Ile Arg Ala Ile Ile Asn His Phe
165 170 175
Asn Pro Lys Ile Glu Ser Tyr Ala Ala Val Asn His Ile Ser Gln Leu
180 185 190
Ser Glu Glu Gln Val Leu Glu Val Val Arg Ala Asn Tyr Asp Thr Leu
195 200 205
Thr Leu Lys Leu Gln Asp Gly Leu Asp Gln Tyr Glu Arg Tyr Ser Glu
210 215 220
Gln His Lys Glu Ala Ala Phe Phe Lys Glu Leu Val Arg Ser Ile Ser
225 230 235 240
Thr Asn Val Arg Arg Asn Leu Val Phe His Thr Leu Ser Gln Glu Val
245 250 255
Leu Leu Lys Glu Phe Ser Thr Ile Ser
260 265
<210>118
<211>278
<212>PRT
<213>人
<400>118
Met Lys Leu Phe Gln Arg Ser Thr Pro Ala Ile Thr Leu Glu Ser Pro
1 5 10 15
Asp Ile Lys Tyr Pro Leu Arg Leu Ile Asp Arg Glu Ile Ile Ser His
20 25 30
Asp Thr Arg Arg Phe Arg Phe Ala Leu Pro Ser Pro Gln His Ile Leu
35 40 45
Gly Leu Pro Val Gly Gln His Ile Tyr Leu Ser Ala Arg Ile Asp Gly
50 55 60
Asn Leu Val Val Arg Pro Tyr Thr Pro Ile Ser Ser Asp Asp Asp Lys
65 70 75 80
Gly Phe Val Asp Leu Val Ile Lys Val Tyr Phe Lys Asp Thr His Pro
85 90 95
Lys Phe Pro Ala Gly Gly Lys Met Ser Gln Tyr Leu Glu Ser Met Gln
100 105 110
Ile Gly Asp Thr Ile Glu Phe Arg Gly Pro Ser Gly Leu Leu Val Tyr
115 120 125
Gln Gly Lys Gly Lys Phe Ala Ile Arg Pro Asp Lys Lys Ser Asn Pro
130 135 140
Ile Ile Arg Thr Val Lys Ser Val Gly Met Ile Ala Gly Gly Thr Gly
145 150 155 160
Ile Thr Pro Met Leu Gln Val Ile Arg Ala Ile Met Lys Asp Pro Asp
165 170 175
Asp His Thr Val Cys His Leu Leu Phe Ala Asn Gln Thr Glu Lys Asp
180 185 190
Ile Leu Leu Arg Pro Glu Leu Glu Glu Leu Arg Asn Lys His Ser Ala
195 200 205
Arg Phe Lys Leu Trp Tyr Thr Leu Asp Arg Ala Pro Glu Ala Trp Asp
210 215 220
Tyr Gly Gln Gly Phe Val Asn Glu Glu Met Ile Arg Asp His Leu Pro
225 230 235 240
Pro Pro Glu Glu Glu Pro Leu Val Leu Met Cys Gly Pro Pro Pro Met
245 250 255
Ile Gln Tyr Ala Cys Leu Pro Asn Leu Asp His Val Gly His Pro Thr
260 265 270
Glu Arg Cys Phe Val Phe
275
<210>119
<211>322
<212>PRT
<213>人
<400>119
Met Glu Gly Ile Ser Asn Phe Lys Thr Pro Ser Lys Leu Ser Glu Lys
1 5 10 15
Lys Lys Ser Val Leu Cys Ser Thr Pro Thr Ile Asn Ile Pro Ala Ser
20 25 30
Pro Phe Met Gln Lys Leu Gly Phe Gly Thr Gly Val Asn Val Tyr Leu
35 40 45
Met Lys Arg Ser Pro Arg Gly Leu Ser His Ser Pro Trp Ala Val Lys
50 55 60
Lys Ile Asn Pro Ile Cys Asn Asp His Tyr Arg Ser Val Tyr Gln Lys
65 70 75 80
Arg Leu Met Asp Glu Ala Lys Ile Leu Lys Ser Leu His His Pro Asn
85 90 95
Ile Val Gly Tyr Arg Ala Phe Thr Glu Ala Asn Asp Gly Ser Leu Cys
100 105 110
Leu Ala Met Glu Tyr Gly Gly Glu Lys Ser Leu Asn Asp Leu Ile Glu
115 120 125
Glu Arg Tyr Lys Ala Ser Gln Asp Pro Phe Pro Ala Ala Ile Ile Leu
130 135 140
Lys Val Ala Leu Asn Met Ala Arg Gly Leu Lys Tyr Leu His Gln Glu
145 150 155 160
Lys Lys Leu Leu His Gly Asp Ile Lys Ser Ser Asn Val Val Ile Lys
165 170 175
Gly Asp Phe Glu Thr Ile Lys Ile Cys Asp Val Gly Val Ser Leu Pro
180 185 190
Leu Asp Glu Asn Met Thr Val Thr Asp Pro Glu Ala Cys Tyr Ile Gly
195 200 205
Thr Glu Pro Trp Lys Pro Lys Glu Ala Val Glu Glu Asn Gly Val Ile
210 215 220
Thr Asp Lys Ala Asp Ile Phe Ala Phe Gly Leu Thr Leu Trp Glu Met
225 230 235 240
Met Thr Leu Ser Ile Pro His Ile Asn Leu Ser Asn Asp Asp Asp Asp
245 250 255
Glu Asp Lys Thr Phe Asp Glu Ser Asp Phe Asp Asp Glu Ala Tyr Tyr
260 265 270
Ala Ala Leu Gly Thr Arg Pro Pro Ile Asn Met Glu Glu Leu Asp Glu
275 280 285
Ser Tyr Gln Lys Val Ile Glu Leu Phe Ser Val Cys Thr Asn Glu Asp
290 295 300
Pro Lys Asp Arg Pro Ser Ala Ala His Ile ValGlu Ala Leu Glu Thr
305 310 315 320
Asp Val
<210>120
<211>878
<212>PRT
<213>人
<400>120
Met Ala Thr Ala Pro Ser Tyr Pro Ala Gly Leu Pro Gly Ser Pro Gly
1 5 10 15
Pro Gly Ser Pro Pro Pro Pro Gly Gly Leu Glu Leu Gln Ser Pro Pro
20 25 30
Pro Leu Leu Pro Gln Ile Pro Ala Pro Gly Ser Gly Val Ser Phe His
35 40 45
Ile Gln Ile Gly Leu Thr Arg Glu Phe Val Leu Leu Pro Ala Ala Ser
50 55 60
Glu Leu Ala His Val Lys Gln Leu Ala Cys Ser Ile Val Asp Gln Lys
65 70 75 80
Phe Pro Glu Cys Gly Phe Tyr Gly Leu Tyr Asp Lys Ile Leu Leu Phe
85 90 95
Lys His Asp Pro Thr Ser Ala Asn Leu Leu Gln Leu Val Arg Ser Ser
100 105 110
Gly Asp Ile Gln Glu Gly Asp Leu Val Glu Val Val Leu Ser Ala Ser
115 120 125
Ala Thr Phe Glu Asp Phe Gln Ile Arg Pro His Ala Leu Thr Val His
130 135 140
Ser Tyr Arg Ala Pro Ala Phe Cys Asp His Cys Gly Glu Met Leu Phe
145 150 155 160
Gly Leu Val Arg Gln Gly Leu Lys Cys Asp Gly Cys Gly Leu Asn Tyr
165 170 175
His Lys Arg Cys Ala Phe Ser Ile Pro Asn Asn Cys Ser Gly Ala Arg
180 185 190
Lys Arg Arg Leu Ser Ser Thr Ser Leu Ala Ser Gly His Ser Val Arg
195 200 205
Leu Gly Thr Ser Glu Ser Leu Pro Cys Thr Ala Glu Glu Leu Ser Arg
210 215 220
Ser Thr Thr Glu Leu Leu Pro Arg Arg Pro Pro Ser Ser Ser Ser Ser
225 230 235 240
Ser Ser Ala Ser Ser Tyr Thr Gly Arg Pro Ile Glu Leu Asp Lys Met
245 250 255
Leu Leu Ser Lys Val Lys Val Pro His Thr Phe Leu Ile His Ser Tyr
260 265 270
Thr Arg Pro Thr Val Cys Gln Ala Cys Lys Lys Leu Leu Lys Gly Leu
275 280 285
Phe Arg Gln Gly Leu Gln Cys Lys Asp Cys Lys Phe Asn Cys His Lys
290 295 300
Arg Cys Ala Thr Arg Val Pro Asn Asp Cys Leu Gly Glu Ala Leu Ile
305 310 315 320
Asn Gly Asp Val Pro Met Glu Glu Ala Thr Asp Phe Ser Glu Ala Asp
325 330 335
Lys Ser Ala Leu Met Asp Glu Ser Glu Asp Ser Gly Val Ile Pro Gly
340 345 350
Ser His Ser Glu Asn Ala Leu His Ala Ser Glu Glu Glu Glu Gly Glu
355 360 365
Gly Gly Lys Ala Gln Ser Ser Leu Gly Tyr Ile Pro Leu Met Arg Val
370 375 380
Val Gln Ser Val Arg His Thr Thr Arg Lys Ser Ser Thr Thr Leu Arg
385 390 395 400
Glu Gly Trp Val Val His Tyr Ser Asn Lys Asp Thr Leu Arg Lys Arg
405 410 415
His Tyr Trp Arg Leu Asp Cys Lys Cys Ile Thr Leu Phe Gln Asn Asn
420 425 430
Thr Thr Asn Arg Tyr Tyr Lys Glu Ile Pro Leu Ser Glu Ile Leu Thr
435 440 445
Val Glu Ser Ala Gln Asn Phe Ser Leu Val Pro Pro Gly Thr Asn Pro
450 455 460
His Cys Phe Glu Ile ValThr Ala Asn Ala Thr Tyr Phe Val Gly Glu
465 470 475 480
Met Pro Gly Gly Thr Pro Gly Gly Pro Ser Gly Gln Gly Ala Glu Ala
485 490 495
Ala Arg Gly Trp Glu Thr Ala Ile Arg Gln Ala Leu Met Pro Val Ile
500 505 510
Leu Gln Asp Ala Pro Ser Ala Pro Gly His Ala Pro His Arg Gln Ala
515 520 525
Ser Leu Ser Ile Ser Val Ser Asn Ser Gln Ile Gln Glu Asn Val Asp
530 535 540
Ile Ala Thr Val Tyr Gln Ile Phe Pro Asp Glu Val Leu Gly Ser Gly
545 550 555 560
Gln Phe Gly Val Val Tyr Gly Gly Lys His Arg Lys Thr Gly Arg Asp
565 570 575
Val Ala Val Lys Val Ile Asp Lys Leu Arg Phe Pro Thr Lys Gln Glu
580 585 590
Ser Gln Leu Arg Asn Glu Val Ala Ile Leu Gln Ser Leu Arg His Pro
595 600 605
Gly Ile Val Asn Leu Glu Cys Met Phe Glu Thr Pro Glu Lys Val Phe
610 615 620
Val Val Met Glu Lys Leu His Gly Asp Met Leu Glu Met Ile Leu Ser
625 630 635 640
Ser Glu Lys Gly Arg Leu Pro Glu Arg Leu Thr Lys Phe Leu Ile Thr
645 650 655
Gln Ile Leu Val Ala Leu Arg His Leu His Phe Lys Asn Ile Val His
660 665 670
Cys Asp Leu Lys Pro Glu Asn Val Leu Leu Ala Ser Ala Asp Pro Phe
675 680 685
Pro Gln Val Lys Leu Cys Asp Phe Gly Phe Ala Arg Ile Ile Gly Glu
690 695 700
Lys Ser Phe Arg Arg Ser Val Val Gly Thr Pro Ala Tyr Leu Ala Pro
705 710 715 720
Glu Val Leu Leu Asn Gln Gly Tyr Asn Arg Ser Leu Asp Met Trp Ser
725 730 735
Val Gly Val Ile Met Tyr Val Ser Leu Ser Gly Thr Phe Pro Phe Asn
740 745 750
Glu Asp Glu Asp Ile Asn Asp Gln Ile Gln Asn Ala Ala Phe Met Tyr
755 760 765
Pro Ala Ser Pro Trp Ser His Ile Ser Ala Gly Ala Ile Asp Leu Ile
770 775 780
Asn Asn Leu Leu Gln Val Lys Met Arg Lys Arg Tyr Ser Val Asp Lys
785 790 795 800
Ser Leu Ser His Pro Trp Leu Gln Glu Tyr Gln Thr Trp Leu Asp Leu
805 810 815
Arg Glu Leu Glu Gly Lys Met Gly Glu Arg Tyr Ile Thr His Glu Ser
820 825 830
Asp Asp Ala Arg Trp Glu Gln Phe Ala Ala Glu His Pro Leu Pro Gly
835 840 845
Ser Gly Leu Pro Thr Asp Arg Asp Leu Gly Gly Ala Cys Pro Pro Gln
850 855 860
Asp His Asp Met Gln Gly Leu Ala Glu Arg Ile Ser Val Leu
865 870 875
<210>121
<211>400
<212>PRT
<213>人
<400>121
Met Thr Ser Tyr Ser Tyr Arg Gln Ser Ser Ala Thr Ser Ser Phe Gly
1 5 10 15
Gly Leu Gly Gly Gly Ser Val Arg Phe Gly Pro Gly Val Ala Phe Arg
20 25 30
Ala Pro Ser Ile His Gly Gly Ser Gly Gly Arg Gly Val Ser Val Ser
35 40 45
Ser Ala Arg Phe Val Ser Ser Ser Ser Ser Gly Ala Tyr Gly Gly Gly
50 55 60
Tyr Gly Gly Val Leu Thr Ala Ser Asp Gly Leu Leu Ala Gly Asn Glu
65 70 75 80
Lys Leu Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser Tyr Leu Asp
85 90 95
Lys Val Arg Ala Leu Glu Ala Ala Asn Gly Glu Leu Glu Val Lys Ile
100 105 110
Arg Asp Trp Tyr Gln Lys Gln Gly Pro Gly Pro Ser Arg Asp Tyr Ser
115 120 125
His Tyr Tyr Thr Thr Ile Gln Asp Leu Arg Asp Lys Ile Leu Gly Ala
130 135 140
Thr Ile Glu Asn Ser Arg Ile Val Leu Gln Ile Asp Asn Ala Arg Leu
145 150 155 160
Ala Ala Asp Asp Phe Arg Thr Lys Phe Glu Thr Glu Gln Ala Leu Arg
165 170 175
Met Ser Val Glu Ala Asp Ile Asn Gly Leu Arg Arg Val Leu Asp Glu
180 185 190
Leu Thr Leu Ala Arg Thr Asp Leu Glu Met Gln Ile Glu Gly Leu Lys
195 200 205
Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu Glu Glu Ile Ser Thr
210 215 220
Leu Arg Gly Gln Val Gly Gly Gln Val Ser Val Glu Val Asp Ser Ala
225 230 235 240
Pro Gly Thr Asp Leu Ala Lys Ile Leu Ser Asp Met Arg Ser Gln Tyr
245 250 255
Glu Val Met Ala Glu Gln Asn Arg Lys Asp Ala Glu Ala Trp Phe Thr
260 265 270
Ser Arg Thr Glu Glu Leu Asn Arg Glu Val Ala Gly His Thr Glu Gln
275 280 285
Leu Gln Met Ser Arg Ser Glu Val Thr Asp Leu Arg Arg Thr Leu Gln
290 295 300
Gly Leu Glu Ile Glu Leu Gln Ser Gln Leu Ser Met Lys Ala Ala Leu
305 310 315 320
Glu Asp Thr Leu Ala Glu Thr Glu Ala Arg Phe Gly Ala Gln Leu Ala
325 330 335
His Ile Gln Ala Leu Ile Ser Gly Ile Glu Ala Gln Leu Gly Asp Val
340 345 350
Arg Ala Asp Ser Glu Arg Gln Asn Gln Glu Tyr Gln Arg Leu Met Asp
355 360 365
Ile Lys Ser Arg Leu Glu Gln Glu Ile Ala Thr Tyr Arg Ser Leu Leu
370 375 380
Glu Gly Gln Glu Asp His Tyr Asn Asn Leu Ser Ala Ser Lys Val Leu
385 390 395 400
<210>122
<211>520
<212>PRT
<213>人
<400>122
Met Arg Ser Pro Glu Gly Tyr Leu Arg Gly Asn Met Ser Glu Asn Glu
1 5 10 15
Glu Glu Glu Ile Ser Gln Gln Glu Gly Ser Gly Asp Tyr Glu Val Glu
20 25 30
Glu Ile Pro Phe Gly Leu Glu Pro Gln Ser Pro Gly Phe Glu Pro Gln
35 40 45
Ser Pro Glu Phe Glu Pro Gln Ser Pro Arg Phe Glu Pro Glu Ser Pro
50 55 60
Gly Phe Glu Ser Arg Ser Pro Gly Leu Val Pro Pro Ser Pro Glu Phe
65 70 75 80
Ala Pro Arg Ser Pro Glu Ser Asp Ser Gln Ser Pro Glu Phe Glu Ser
85 90 95
Gln Ser Pro Arg Tyr Glu Pro Gln Ser Pro Gly Tyr Glu Pro Arg Ser
100 105 110
Pro Gly Tyr Glu Pro Arg Ser Pro Gly Tyr Glu Ser Glu Ser Ser Arg
115 120 125
Tyr Glu Ser Gln Asn Thr Glu Leu Lys Thr Gln Ser Pro Glu Phe Glu
130 135 140
Ala Gln Ser Ser Lys Phe Gln Glu Gly Ala Glu Met Leu Leu Asn Pro
145 150 155 160
Asp Glu Lys Ser Pro Leu Asn Ile Ser Val Gly Val His Pro Leu Asp
165 170 175
Ser Phe Thr Gln Gly Phe Gly Glu Gln Pro Thr Gly Asp Leu Pro Ile
180 185 190
Gly Pro Pro Phe Glu Met Pro Thr Gly Ala Leu Leu Ser Thr Pro Gln
195 200 205
Phe Glu Met Leu Gln Asn Pro Leu Gly Leu Thr Gly Ala Leu Arg Gly
210 215 220
Pro Gly Arg Arg Gly Gly Arg Ala Arg Gly Gly Gln Gly Pro Arg Pro
225 230 235 240
Asn Ile Cys Gly Ile Cys Gly Lys Ser Phe Gly Arg Gly Ser Thr Leu
245 250 255
Ile Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
260 265 270
Val Cys Ser Lys Ala Phe Ser Gln Ser Ser Asp Leu Ile Lys His Gln
275 280 285
Arg Thr His Thr Gly Glu Arg Pro Tyr Lys Cys Pro Arg Cys Gly Lys
290 295 300
Ala Phe Ala Asp Ser Ser Tyr Leu Leu Arg His Gln Arg Thr His Ser
305 310 315 320
Gly Gln Lys Pro Tyr Lys Cys Pro His Cys Gly Lys Ala Phe Gly Asp
325 330 335
Ser Ser Tyr Leu Leu Arg His Gln Arg Thr His Ser His Glu Arg Pro
340 345 350
Tyr Ser Cys Thr Glu Cys Gly Lys Cys Tyr Ser Gln Asn Ser Ser Leu
355 360 365
Arg Ser His Gln Arg Val His Thr Gly Gln Arg Pro Phe Ser Cys Gly
370 375 380
Ile Cys Gly Lys Ser Phe Ser Gln Arg Ser Ala Leu Ile Pro His Ala
385 390 395 400
Arg Ser His Ala Arg Glu Lys Pro Phe Lys Cys Pro Glu Cys Gly Lys
405 410 415
Arg Phe Gly Gln Ser Ser Val Leu Ala Ile His Ala Arg Thr His Leu
420 425 430
Pro Gly Arg Thr Tyr Ser Cys Pro Asp Cys Gly Lys Thr Phe Asn Arg
435 440 445
Ser Ser Thr Leu Ile Gln His Gln Arg Ser His Thr Gly Glu Arg Pro
450 455 460
Tyr Arg Cys Ala Val Cys Gly Lys Gly Phe Cys Arg Ser Ser Thr Leu
465 470 475 480
Leu Gln His His Arg Val His Ser Gly Glu Arg Pro Tyr Lys Cys Asp
485 490 495
Asp Cys Gly Lys Ala Phe Ser Gln Ser Ser Asp Leu Ile Arg His Gln
500 505 510
Arg Thr His Ala Ala Gly Arg Arg
515 520
<210>123
<211>383
<212>PRT
<213>人
<400>123
Met Glu Arg Arg Ala Arg Ser Ser Ser Arg Glu Ser Arg Gly Arg Gly
1 5 10 15
Gly Arg Thr Pro His Lys Glu Asn Lys Arg Ala Lys Ala Glu Arg Ser
20 25 30
Gly Gly Gly Arg Gly Arg Gln Glu Ala Gly Pro Glu Pro Ser Gly Ser
35 40 45
Gly Arg Ala Gly Thr Pro Gly Glu Pro Arg Ala Pro Ala Ala Thr Val
50 55 60
Val Asp Val Asp Glu Val Arg Gly Ser Gly Glu Glu Gly Thr Glu Val
65 70 75 80
Val Ala Leu Leu Glu Ser Glu Arg Pro Glu Glu Gly Thr Lys Ser Ser
85 90 95
Gly Leu Gly Ala Cys Glu Trp Leu Leu Val Leu Ile Ser Leu Leu Phe
100 105 110
Ile Ile Met Thr Phe Pro Phe Ser Ile Trp Phe Cys Val Lys Val Val
115 120 125
Gln Glu Tyr Glu Arg Val Ile Ile Phe Arg Leu Gly His Leu Leu Pro
130 135 140
Gly Arg Ala Lys Gly Pro Gly Leu Phe Phe Phe Leu Pro Cys Leu Asp
145 150 155 160
Thr Tyr His Lys Val Asp Leu Arg Leu Gln Thr Leu Glu Ile Pro Phe
165 170 175
His Glu Ile Val Thr Lys Asp Met Phe Ile Met Glu Ile Asp Ala Ile
180 185 190
Cys Tyr Tyr Arg Met Glu Asn Ala Ser Leu Leu Leu Ser Ser Leu Ala
195 200 205
His Val Ser Lys Ala Val Gln Phe Leu Val Gln Thr Thr Met Lys Arg
210 215 220
Leu Leu Ala His Arg Ser Leu Thr Glu Ile Leu Leu Glu Arg Lys Ser
225 230 235 240
Ile Ala Gln Asp Ala Lys Val Ala Leu Asp Ser Val Thr Cys Ile Trp
245 250 255
Gly Ile Lys Val Glu Arg Ile Glu Ile Lys Asp Val Arg Leu Pro Ala
260 265 270
Gly Leu Gln His Ser Leu Ala Val Glu Ala Glu Ala Gln Arg Gln Ala
275 280 285
Lys Val Arg Met Ile Ala Ala Glu Ala Glu Lys Ala Ala Ser Glu Ser
290 295 300
Leu Arg Met Ala Ala Glu Ile Leu Ser Gly Thr Pro Ala Ala Val Gln
305 310 315 320
Leu Arg Tyr Leu His Thr Leu Gln Ser Leu Ser Thr Glu Lys Pro Ser
325 330 335
Thr Val Val Leu Pro Leu Pro Phe Asp Leu Leu Asn Cys Leu Ser Ser
340 345 350
Pro Ser Asn Arg Thr Gln Gly Ser Leu Pro Phe Pro Ser Pro Ser Lys
355 360 365
Pro Val Glu Pro Leu Asn Pro Lys Lys Lys Asp Ser Pro Met Leu
370 375 380
<210>124
<211>128
<212>PRT
<213>人
<400>124
Met Thr Ser Leu Phe Ala Gln Glu Ile Arg Leu Ser Lys Arg His Glu
l 5 10 15
Glu Ile Val Ser Gln Arg Leu Met Leu Leu Gln Gln Met Glu Asn Lys
20 25 30
Leu Gly Asp Gln His Thr Glu Lys Ala Ser Gln Leu Gln Thr Val Glu
35 40 45
Thr Ala Phe Lys Arg Asn Leu Ser Leu Leu Lys Asp Ile Glu Ala Ala
50 55 60
Glu Lys Ser Leu Gln Thr Arg Ile His Pro Leu Pro Arg Pro Glu Val
65 70 75 80
Val Ser Leu Glu Thr Arg Tyr Trp Ala Ser Val Glu Glu Tyr Ile Pro
85 90 95
Lys Trp Glu Gln Phe Leu Leu Gly Arg Ala Pro Tyr Pro Phe Ala Val
100 105 110
Glu Asn Gln Asn Glu Ala Glu Asn Thr Ile Gln Asn Glu Ala Gln Arg
115 120 125
<210>125
<211>363
<212>PRT
<213>人
<400>125
Met Lys Gly Asn Ser Thr Leu Ala Thr Thr Ser Lys Asn Ile Thr Ser
1 5 10 15
Gly Leu His Phe Gly Leu Val Asn Ile Ser Gly Asn Asn Glu Ser Thr
20 25 30
Leu Asn Cys Ser Gln Lys Pro Ser Asp Lys His Leu Asp Ala Ile Pro
35 40 45
Ile Leu Tyr Tyr Ile Ile Phe Val Ile Gly Phe Leu Val Asn Ile Val
50 55 60
Val Val Thr Leu Phe Cys Cys Gln Lys Gly Pro Lys Lys Val Ser Ser
65 70 75 80
Ile Tyr Ile Phe Asn Leu Ala Val Ala Asp Leu Leu Leu Leu Ala Thr
85 90 95
Leu Pro Leu Trp Ala Thr Tyr Tyr Ser Tyr Arg Tyr Asp Trp Leu Phe
100 105 110
Gly Pro Val Met Cys Lys Val Phe Gly Ser Phe Leu Thr Leu Asn Met
115 120 125
Phe Ala Ser Ile Phe Phe Ile Thr Cys Met Ser Val Asp Arg Tyr Gln
130 135 140
Ser Val Ile Tyr Pro Phe Leu Ser Gln Arg Arg Asn Pro Trp Gln Ala
145 150 155 160
Ser Tyr Ile Val Pro Leu Val Trp Cys Met Ala Cys Leu Ser Ser Leu
165 170 175
Pro Thr Phe Tyr Phe Arg Asp Val Arg Thr Ile Glu Tyr Leu Gly Val
180 185 190
Asn Ala Cys Ile Met Ala Phe Pro Pro Glu Lys Tyr Ala Gln Trp Ser
195 200 205
Ala Gly Ile Ala Leu Met Lys Asn Ile Leu Gly Phe Ile Ile Pro Leu
210 215 220
Ile Phe Ile Ala Thr Cys Tyr Phe Gly Ile Arg Lys His Leu Leu Lys
225 230 235 240
Thr Asn Ser Tyr Gly Lys Asn Arg Ile Thr Arg Asp Gln Val Leu Lys
245 250 255
Met Ala Ala Ala Val Val Leu Ala Phe Ile Ile Cys Trp Leu Pro Phe
260 265 270
His Val Leu Thr Phe Leu Asp Ala Leu Ala Trp Met Gly Val Ile Asn
275 280 285
Ser Cys Glu Val Ile Ala Val Ile Asp Leu Ala Leu Pro Phe Ala Ile
290 295 300
Leu Leu Gly Phe Thr Asn Ser Cys Val Asn Pro Phe Leu Tyr Cys Phe
305 310 315 320
Val Gly Asn Arg Phe Gln Gln Lys Leu Arg Ser Val Phe Arg Val Pro
325 330 335
Ile Thr Trp Leu Gln Gly Lys Arg Glu Ser Met Ser Cys Arg Lys Ser
340 345 350
Ser Ser Leu Arg Glu Met Glu Thr Phe Val Ser
355 360
<210>126
<211>366
<212>PRT
<213>人
<400>126
Met Asp Phe Leu Asn Ser Ser Asp Gln Asn Leu Thr Ser Glu Glu Leu
1 5 10 15
Leu Asn Arg Met Pro Ser Lys Ile Leu Val Ser Leu Thr Leu Ser Gly
20 25 30
Leu Ala Leu Met Thr Thr Thr Ile Asn Ser Leu Val Ile Ala Ala Ile
35 40 45
Ile Val Thr Arg Lys Leu His His Pro Ala Asn Tyr Leu Ile Cys Ser
50 55 60
Leu Ala Val Thr Asp Phe Leu Val Ala Val Leu Val Met Pro Phe Ser
65 70 75 80
Ile Val Tyr Ile Val Arg Glu Ser Trp Ile Met Gly Gln Val Val Cys
85 90 95
Asp Ile Trp Leu Ser Val Asp Ile Thr Cys Cys Thr Cys Ser Ile Leu
100 105 110
His Leu Ser Ala Ile Ala Leu Asp Arg Tyr Arg Ala Ile Thr Asp Ala
115 120 125
Val Glu Tyr Ala Arg Lys Arg Thr Pro Lys His Ala Gly Ile Met Ile
130 135 140
Thr Ile Val Trp Ile Ile Ser Val Phe Ile Ser Met Pro Pro Leu Phe
145 150 155 160
Trp Arg His Gln Gly Thr Ser Arg Asp Asp Glu Cys Ile Ile Lys His
165 170 175
Asp His Ile Val Ser Thr Ile Tyr Ser Thr Phe Gly Ala Phe Tyr Ile
180 185 190
Pro Leu Ala Leu Ile Leu Ile Leu Tyr Tyr Lys Ile Tyr Arg Ala Ala
195 200 205
Lys Thr Leu Tyr His Lys Arg Gln Ala Ser Arg Ile Ala Lys Glu Glu
210 215 220
Val Asn Gly Gln Val Leu Leu Glu Ser Gly Glu Lys Ser Thr Lys Ser
225 230 235 240
Val Ser Thr Ser Tyr Val Leu Glu Lys Ser Leu Ser Asp Pro Ser Thr
245 250 255
Asp Phe Asp Lys Ile His Ser Thr Val Arg Ser Leu Arg Ser Glu Phe
260 265 270
Lys His Glu Lys Ser Trp Arg Arg Gln Lys Ile Ser Gly Thr Arg Glu
275 280 285
Arg Lys Ala Ala Thr Thr Leu Gly Leu Ile Leu Gly Ala Phe Val Ile
290 295 300
Cys Trp Leu Pro Phe Phe Val Lys Glu Leu Val Val Asn Val Cys Asp
305 310 315 320
Lys Cys Lys Ile Ser Glu Glu Met Ser Asn Phe Leu Ala Trp Leu Gly
325 330 335
Tyr Leu Asn Ser Leu Ile Asn Pro Leu Ile Tyr Thr Ile Phe Asn Glu
340 345 350
Asp Phe Lys Lys Ala Phe Gln Lys Leu Val Arg Cys Arg Cys
355 360 365
<210>127
<211>747
<212>PRT
<213>人
<400>127
Met Ser Lys Leu Lys Ser Ser Glu Ser Val Arg Val Val Val Arg Cys
1 5 10 15
Arg Pro Met Asn Gly Lys Glu Lys Ala Ala Ser Tyr Asp Lys Val Val
20 25 30
Asp Val Asp Val Lys Leu Gly Gln Val Ser Val Lys Asn Pro Lys Gly
35 40 45
Thr Ala His Glu Met Pro Lys Thr Phe Thr Phe Asp Ala Val Tyr Asp
50 55 60
Trp Asn Ala Lys Gln Phe Glu Leu Tyr Asp Glu Thr Phe Arg Pro Leu
65 70 75 80
Val Asp Ser Val Leu Gln Gly Phe Asn Gly ThrIle Phe Ala Tyr Gly
85 90 95
Gln Thr Gly Thr Gly Lys Thr Tyr Thr Met Glu Gly Ile Arg Gly Asp
100 105 110
Pro Glu Lys Arg Gly Val Ile Pro Asn Ser Phe Asp His Ile Phe Thr
115 120 125
His Ile Ser Arg Ser Gln Asn Gln Gln Tyr Leu Val Arg Ala Ser Tyr
130 135 140
Leu Glu Ile Tyr Gln Glu Glu Ile Arg Asp Leu Leu Ser Lys Asp Gln
145 150 155 160
Thr Lys Arg Leu Glu Leu Lys Glu Arg Pro Asp Thr Gly Val Tyr Val
165 170 175
Lys Asp Leu Ser Ser Phe Val Thr Lys Ser Val Lys Glu Ile Glu His
180 185 190
Val Met Asn Val Gly Asn Gln Asn Arg Ser Val Gly Ala Thr Asn Met
195 200 205
Asn Glu His Ser Ser Arg Ser His Ala Ile Phe Val Ile Thr Ile Glu
210 215 220
Cys Ser Glu Val Gly Leu Asp Gly Glu Asn His Ile Arg Val Gly Lys
225 230 235 240
Leu Asn Leu Val Asp Leu Ala Gly Ser Glu Arg Gln Ala Lys Thr Gly
245 250 255
Ala Gln Gly Glu Arg Leu Lys Glu Ala Thr Lys Ile Asn Leu Ser Leu
260 265 270
Ser Ala Leu Gly Asn Val Ile Ser Ala Leu Val Asp Gly Lys Ser Thr
275 280 285
His Ile Pro Tyr Arg Asp Ser Lys Leu Thr Arg Leu Leu Gln Asp Ser
290 295 300
Leu Gly Gly Asn Ala Lys Thr Val Met Val Ala Asn Val Gly Pro Ala
305 310 315 320
Ser Tyr Asn Val Glu Glu Thr Leu Thr Thr Leu Arg Tyr Ala Asn Arg
325 330 335
Ala Lys Asn Ile Lys Asn Lys Pro Arg Val Asn Glu Asp Pro Lys Asp
340 345 350
Ala Leu Leu Arg Glu Phe Gln Glu Glu Ile Ala Arg Leu Lys Ala Gln
355 360 365
Leu Glu Lys Arg Ser Ile Gly Arg Arg Lys Arg Arg Glu Lys Arg Arg
370 375 380
Glu Gly Gly Gly Ser Gly Gly Gly Gly Glu Glu Glu Glu Glu Glu Gly
385 390 395 400
Glu Glu Gly Glu Glu Glu Gly Asp Asp Lys Asp Asp Tyr Trp Arg Glu
405 410 415
Gln Gln Glu Lys Leu Glu Ile Glu Lys Arg Ala Ile Val Glu Asp His
420 425 430
Ser Leu Val Ala Glu Glu Lys Met Arg Leu Leu Lys Glu Lys Glu Lys
435 440 445
Lys Met Glu Asp Leu Arg Arg Glu Lys Asp Ala Ala Glu Met Leu Gly
450 455 460
Ala Lys Ile Lys Ala Met Glu Ser Lys Leu Leu Val Gly Gly Lys Asn
465 470 475 480
Ile Val Asp His Thr Asn Glu Gln Gln Lys Ile Leu Glu Gln Lys Arg
485 490 495
Gln Glu Ile Ala Glu Gln Lys Arg Arg Glu Arg Glu Ile Gln Gln Gln
500 505 510
Met Glu Ser Arg Asp Glu Glu Thr Leu Glu Leu Lys Glu Thr Tyr Ser
515 520 525
Ser Leu Gln Gln Glu Val Asp Ile Lys Thr Lys Lys Leu Lys Lys Leu
530 535 540
Phe Ser Lys Leu Gln Ala Val Lys Ala Glu Ile His Asp Leu Gln Glu
545 550 555 560
Glu His Ile Lys Glu Arg Gln Glu Leu Glu Gln Thr Gln Asn Glu Leu
565 570 575
Thr Arg Glu Leu Lys Leu Lys Hi s Leu Ile Ile Glu Asn Phe Ile Pro
580 585 590
Leu Glu Glu Lys Ser Lys Ile Met Asn Arg Ala Phe Phe Asp Glu Glu
595 600 605
Glu Asp His Trp Lys Leu His Pro Ile Thr Arg Leu Glu Asn Gln Gln
610 615 620
Met Met Lys Arg Pro Val Ser Ala Val Gly Tyr Lys Arg Pro Leu Ser
625 630 635 640
Gln His Ala Arg Met Ser Met Met Ile Arg Pro Glu Ala Arg Tyr Arg
645 650 655
Ala Glu Asn Ile Val Leu Leu Glu Leu Asp Met Pro Ser Arg Thr Thr
660 665 670
Arg Asp Tyr Glu Gly Pro Ala Ile Ala Pro Lys Val Gln Ala Ala Leu
675 680 685
Asp Ala Ala Leu Gln Asp Glu Asp Glu Ile Gln Val Asp Ala Ser Ser
690 695 700
Phe Glu Ser Thr Ala Asn Lys Lys Ser Lys Ala Arg Pro Lys Ser Gly
705 710 715 720
Arg Lys Ser Gly Ser Ser Ser Ser Ser Ser Gly Thr Pro Ala Ser Gln
725 730 735
Leu Tyr Pro Gln Ser Arg Gly Leu Val Pro Lys
740 745
<210>128
<211>172
<212>PRT
<213>人
<400>128
Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala
1 5 10 15
Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu
20 25 30
Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro
35 40 45
Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val
50 55 60
Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu Pro
65 70 75 80
Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile
85 90 95
Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Val Val Tyr Leu
100 105 110
His Asn Asn Asn Ile Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro
115 120 125
Gly His Asn Thr Lys Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser
130 135 140
Asn Pro Val Gln Tyr Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys Val
145 150 155 160
Tyr Val Arg Ser Ala Ile Gln Leu Gly Asn Tyr Lys
165 170
<210>129
<211>268
<212>PRT
<213>人
<400>129
Met Glu Asp Phe Leu Leu Ser Asn Gly Tyr Gln Leu Gly Lys Thr Ile
1 5 10 15
Gly Glu Gly Thr Tyr Ser Lys Val Lys Glu Ala Phe Ser Lys Lys His
20 25 30
Gln Arg Lys Val Ala Ile Lys Val Ile Asp Lys Met Gly Gly Pro Glu
35 40 45
Glu Phe Ile Gln Arg Phe Leu Pro Arg Glu Leu Gln Ile Val Arg Thr
50 55 60
Leu Asp His Lys Asn Ile Ile Gln Val Tyr Glu Met Leu Glu Ser Ala
65 70 75 80
Asp Gly Lys Ile Cys Leu Val Met Glu Leu Ala Glu Gly Gly Asp Val
85 90 95
Phe Asp Cys Val Leu Asn Gly Gly Pro Leu Pro Glu Ser Arg Ala Lys
100 105 110
Ala Leu Phe Arg Gln Met Val Glu Ala Ile Arg Tyr Cys His Gly Cys
115 120 125
Gly Val Ala His Arg Asp Leu Lys Cys Glu Asn Ala Leu Leu Gln Gly
130 135 140
Phe Asn Leu Lys Leu Thr Asp Phe Gly Phe Ala Lys Val Leu Pro Lys
145 150 155 160
Ser His Arg Glu Leu Ser Gln Thr Phe Cys Gly Ser Thr Ala Tyr Ala
165 170 175
Ala Pro Glu Val Leu Gln Gly Ile Pro His Asp Ser Lys Lys Gly Asp
180 185 190
Val Trp Ser Met Gly Val Val Leu Tyr Val Met Leu Cys Ala Ser Leu
195 200 205
Pro Phe Asp Asp Thr Asp Ile Pro Lys Met Leu Trp Gln Gln Gln Lys
210 215 220
Gly Val Ser Phe Pro Thr His Leu Ser Ile Ser Ala Asp Cys Gln Asp
225 230 235 240
Leu Leu Lys Arg Leu Leu Glu Pro Asp MetIle Leu Arg Pro Ser Ile
245 250 255
Glu Glu Val Ser Trp His Pro Trp Leu Ala Ser Thr
260 265
<210>130
<211>133
<212>PRT
<213>人
<400>130
Met Arg Arg Ser Leu Arg Ala Gly Lys Arg Arg Gln Thr Ala Gly Arg
1 5 10 15
Lys Ser Lys Ser Pro Pro Lys Val Pro Ile Val Ile Gln Asp Asp Ser
20 25 30
Leu Pro Ala Gly Pro Pro Pro Gln Ile Arg Ile Leu Lys Arg Pro Thr
35 40 45
Ser Asn Gly Val Val Ser Ser Pro Asn Ser Thr Ser Arg Pro Thr Leu
50 55 60
Pro Val Lys Ser Leu Ala Gln Arg Glu Ala Glu Tyr Ala Glu Ala Arg
65 70 75 80
Lys Arg Ile Leu Gly Ser Ala Ser Pro Glu Glu Glu Gln Glu Lys Pro
85 90 95
Ile Leu Asp Arg Pro Thr Arg Ile Ser Gln Pro Glu Asp Ser Arg Gln
100 105 110
Pro Asn Asn Val Ile Arg Gln Pro Leu Gly Pro Asp Gly Ser Gln Gly
115 120 125
Phe Lys Gln Arg Arg
130
<210>131
<211>472
<212>PRT
<213>人
<400>131
Met Lys Ser Ile Leu Asp Gly Leu Ala Asp Thr Thr Phe Arg Thr Ile
1 5 10 15
Thr Thr Asp Leu Leu Tyr Val Gly Ser Asn Asp Ile Gln Tyr Glu Asp
20 25 30
Ile Lys Gly Asp Met Ala Ser Lys Leu Gly Tyr Phe Pro Gln Lys Phe
35 40 45
Pro Leu Thr Ser Phe Arg Gly Ser Pro Phe Gln Glu Lys Met Thr Ala
50 55 60
Gly Asp Asn Pro Gln Leu Val Pro Ala Asp Gln Val Asn Ile Thr Glu
65 70 75 80
Phe Tyr Asn Lys Ser Leu Ser Ser Phe Lys Glu Asn Glu Glu Asn Ile
85 90 95
Gln Cys Gly Glu Asn Phe Met Asp Ile Glu Cys Phe Met Val Leu Asn
100 105 110
Pro Ser Gln Gln Leu Ala Ile Ala Val Leu Ser Leu Thr Leu Gly Thr
115 120 125
Phe Thr Val Leu Glu Asn Leu Leu Val Leu Cys Val Ile Leu His Ser
130 135 140
Arg Ser Leu Arg Cys Arg Pro Ser Tyr His Phe Ile Gly Ser Leu Ala
145 150 155 160
Val Ala Asp Leu Leu Gly Ser Val Ile Phe Val Tyr Ser Phe Ile Asp
165 170 175
Phe His Val Phe His Arg Lys Asp Ser Arg Asn Val Phe Leu Phe Lys
180 185 190
Leu Gly Gly Val Thr Ala Ser Phe Thr Ala Ser Val Gly Ser Leu Phe
195 200 205
Leu Thr Ala Ile Asp Arg Tyr Ile Ser Ile His Arg Pro Leu Ala Tyr
210 215 220
Lys Arg Ile Val Thr Arg Pro Lys Ala Val Val Ala Phe Cys Leu Met
225 230 235 240
Trp Thr Ile Ala Ile Val Ile Ala Val Leu Pro Leu Leu Gly Trp Asn
245 250 255
Cys Glu Lys Leu Gln Ser Val Cys Ser Asp Ile Phe Pro His Ile Asp
260 265 270
Glu Thr Tyr Leu Met Phe Trp Ile Gly Val Thr Ser Val Leu Leu Leu
275 280 285
Phe Ile Val Tyr Ala Tyr Met Tyr Ile Leu Trp Lys Ala His Ser His
290 295 300
Ala Val Arg Met Ile Gln Arg Gly Thr Gln Lys Ser Ile Ile Ile His
305 310 315 320
Thr Ser Glu Asp Gly Lys Val Gln Val Thr Arg Pro Asp Gln Ala Arg
325 330 335
Met Asp Ile Arg Leu Ala Lys Thr Leu Val Leu Ile Leu Val Val Leu
340 345 350
Ile Ile Cys Trp Gly Pro Leu Leu Ala Ile Met Val Tyr Asp Val Phe
355 360 365
Gly Lys Met Asn Lys Leu Ile Lys Thr Val Phe Ala Phe Cys Ser Met
370 375 380
Leu Cys Leu Leu Asn Ser Thr Val Asn Pro Ile Ile Tyr Ala Leu Arg
385 390 395 400
Ser Lys Asp Leu Arg His Ala Phe Arg Ser Met Phe Pro Ser Cys Glu
405 410 415
Gly Thr Ala Gln Pro Leu Asp Asn Ser Met Gly Asp Ser Asp Cys Leu
420 425 430
His Lys His Ala Asn Asn Ala Ala Ser Val His Arg Ala Ala Glu Ser
435 440 445
Cys Ile Lys Ser Thr Val Lys Ile Ala Lys Val Thr Met Ser Val Ser
450 455 460
Thr Asp Thr Ser Ala Glu Ala Leu
465 470
<210>132
<211>361
<212>PRT
<213>人
<400>132
Met Ser Thr Ala Arg Glu Gln Pro Ile Phe Ser Thr Arg Ala His Val
1 5 10 15
Phe Gln Ile Asp Pro Ala Thr Lys Arg Asn Trp Ile Pro Ala Gly Lys
20 25 30
His Ala Leu Thr Val Ser Tyr Phe Tyr Asp Ala Thr Arg Asn Val Tyr
35 40 45
Arg Ile Ile Ser Ile Gly Gly Ala Lys Ala Ile Ile Asn Ser Thr Val
50 55 60
Thr Pro Asn Met Thr Phe Thr Lys Thr Ser Gln Lys Phe Gly Gln Trp
65 70 75 80
Ala Asp Ser Arg Ala Asn Thr ValTyr Gly Leu Gly Phe Ala Ser Glu
85 90 95
Gln His Leu Thr Gln Phe Ala Glu Lys Phe Gln Glu Val Lys Glu Ala
100 105 110
Ala Arg Leu Ala Arg Glu Lys Ser Gln Asp Gly Gly Glu Leu Thr Ser
115 120 125
Pro Ala Leu Gly Leu Ala Ser His Gln Val Pro Pro Ser Pro Leu Val
130 135 140
Ser Ala Asn Gly Pro Gly Glu Glu Lys Leu Phe Arg Ser Gln Ser Ala
145 150 155 160
Asp Ala Pro Gly Pro Thr Glu Arg Glu Arg Leu Lys Lys Met Leu Ser
165 170 175
Glu Gly Ser Val Gly Glu Val Gln Trp Glu Ala Glu Phe Phe Ala Leu
180 185 190
Gln Asp Ser Asn Asn Lys Leu Ala Gly Ala Leu Arg Glu Ala Asn Ala
195 200 205
Ala Ala Ala Gln Trp Arg Gln Gln Leu Glu Ala Gln Arg Ala Glu Ala
210 215 220
Glu Arg Leu Arg Gln Arg Val Ala Glu Leu Glu Ala Gln Ala Ala Ser
225 230 235 240
Glu Val Thr Pro Thr Gly Glu Lys Glu Gly Leu Gly Gln Gly Gln Ser
245 250 255
Leu Glu Gln Leu Glu Ala Leu Val Gln Thr Lys Asp Gln Glu Ile Gln
260 265 270
Thr Leu Lys Ser Gln Thr Gly Gly Pro Arg Glu Ala Leu Glu Ala Ala
275 280 285
Glu Arg Glu Glu Thr Gln Gln Lys Val Gln Asp Leu Glu Thr Arg Asn
290 295 300
Ala Glu Leu Glu His Gln Leu Arg Ala Met Glu Arg Ser Leu Glu Glu
305 310 315 320
Ala Arg Ala Glu Arg Glu Arg Ala Arg Ala Glu Val Gly Arg Ala Ala
325 330 335
Gln Leu Leu Asp Val Arg Leu Phe Glu Leu Ser Glu Leu Arg Glu Gly
340 345 350
Leu Ala Arg Leu Ala Glu Ala Ala Pro
355 360
<210>133
<211>362
<212>PRT
<213>人
<400>133
Met Gly Thr Glu Ala Thr Glu Gln Val Ser Trp Gly His Tyr Ser Gly
1 5 10 15
Asp Glu Glu Asp Ala Tyr Ser Ala Glu Pro Leu Pro Glu Leu Cys Tyr
20 25 30
Lys Ala Asp Val Gln Ala Phe Ser Arg Ala Phe Gln Pro Ser Val Ser
35 40 45
Leu Thr Val Ala Ala Leu Gly Leu Ala Gly Asn Gly Leu Val Leu Ala
50 55 60
Thr His Leu Ala Ala Arg Arg Ala Ala Arg Ser Pro Thr Ser Ala His
65 70 75 80
Leu Leu Gln Leu Ala Leu Ala Asp Leu Leu Leu Ala Leu Thr Leu Pro
85 90 95
Phe Ala Ala Ala Gly Ala Leu Gln Gly Trp Ser Leu Gly Ser Ala Thr
100 105 110
Cys Arg Thr Ile Ser Gly Leu Tyr Ser Ala Ser Phe His Ala Gly Phe
115 120 125
Leu Phe Leu Ala Cys Ile Ser Ala Asp Arg Tyr Val Ala Ile Ala Arg
130 135 140
Ala Leu Pro Ala Gly Pro Arg Pro Ser Thr Pro Gly Arg Ala His Leu
145 150 155 160
Val Ser Val Ile Val Trp Leu Leu Ser Leu Leu Leu Ala Leu Pro Ala
165 170 175
Leu Leu Phe Ser Gln Asp Gly Gln Arg Glu Gly Gln Arg Arg Cys Arg
180 185 190
Leu Ile Phe Pro Glu Gly Leu Thr Gln Thr Val Lys Gly Ala Ser Ala
195 200 205
Val Ala Gln Val Ala Leu Gly Phe Ala Leu Pro Leu Gly Val Met Val
210 215 220
Ala Cys Tyr Ala Leu Leu Gly Arg Thr Leu Leu Ala Ala Arg Gly Pro
225 230 235 240
Glu Arg Arg Arg Ala Leu Arg Val Val Val Ala Leu Val Ala Ala Phe
245 250 255
Val Val Leu Gln Leu Pro Tyr Ser Leu Ala Leu Leu Leu Asp Thr Ala
260 265 270
Asp Leu Leu Ala Ala Arg Glu Arg Ser Cys Pro Ala Ser Lys Arg Lys
275 280 285
Asp Val Ala Leu Leu Val Thr Ser Gly Leu Ala Leu Ala Arg Cys Gly
290 295 300
Leu Asn Pro Val Leu Tyr Ala Phe Leu Gly Leu Arg Phe Arg Gln Asp
305 310 315 320
Leu Arg Arg Leu Leu Arg Gly Gly Ser Ser Pro Ser Gly Pro Gln Pro
325 330 335
Arg Arg Gly Cys Pro Arg Arg Pro Arg Leu Ser Ser Cys Ser Ala Pro
340 345 350
Thr Glu Thr His Ser Leu Ser Trp Asp Asn
355 360
<210>134
<211>520
<212>PRT
<213>人
<400>134
Met Arg Val Glu Ser Gly Ser Ala Gln Glu Arg Gly Ile Leu Leu Glu
5 10 15
Ser Leu Ser Thr Leu Leu Glu Lys Thr Thr Ala Ser His Glu Gly Arg
20 25 30
Ala Pro Gly Asn Arg Glu Leu Thr Asp Leu Leu Pro Pro Glu Val Cys
35 40 45
Ser Leu Leu Asn Pro Ala Ala Ile Tyr Ala Asn Asn Glu Ile Ser Leu
50 55 60
Arg Asp Val Glu Val Tyr Gly Phe Asp Tyr Asp Tyr Thr Leu Ala Gln
65 70 75 80
Tyr Ala Asp Ala Leu His Pro Glu Ile Phe Ser Thr Ala Arg Asp Ile
85 90 95
Leu Ile Glu His Tyr Lys Tyr Pro Glu Gly Ile Arg Lys Tyr Asp Tyr
100 105 110
Asn Pro Ser Phe Ala Ile Arg Gly Leu His Tyr Asp Ile Gln Lys Ser
115 120 125
Leu Leu Met Lys Ile Asp Ala Phe His Tyr Val Gln Leu Gly Thr Ala
130 135 140
Tyr Arg Gly Leu Gln Pro Val Pro Asp Glu Glu Val Ile Glu Leu Tyr
145 150 155 160
Gly Gly Thr Gln His Ile Pro Leu Tyr Gln Met Ser Gly Phe Tyr Gly
165 170 175
Lys Gly Pro Ser Ile Lys Gln Phe Met Asp Ile Phe Ser Leu Pro Glu
180 185 190
Met Ala Leu Leu Ser Cys Val Val Asp Tyr Phe Leu Gly His Ser Leu
195 200 205
Glu Phe Asp Gln Ala His Leu Tyr Lys Asp Val Thr Asp Ala Ile Arg
210 215 220
Asp Val His Val Lys Gly Leu Met Tyr Gln Trp Ile Glu Gln Asp Met
225 230 235 240
Glu Lys Tyr Ile Leu Arg Gly Asp Glu Thr Phe Ala Val Leu Ser Arg
245 250 255
Leu Val Ala His Gly Lys Gln Leu Phe Leu Ile Thr Asn Ser Pro Phe
260 265 270
Ser Phe Val Asp Lys Gly Met Arg His Met Val Gly Pro Asp Trp Arg
275 280 285
Gln Leu Phe Asp Val Val Ile Val Gln Ala Asp Lys Pro Ser Phe Phe
290 295 300
Thr Asp Arg Arg Lys Pro Phe Arg Lys Leu Asp Glu Lys Gly Ser Leu
305 310 315 320
Gln Trp Asp Arg Ile Thr Arg Leu Glu Lys Gly Lys Ile Tyr Arg Gln
325 330 335
Gly Asn Leu Phe Asp Phe Leu Arg Leu Thr Glu Trp Arg Gly Pro Arg
340 345 350
Val Leu Tyr Phe Gly Asp His Leu Tyr Ser Asp Leu Ala Asp Leu Met
355 360 365
Leu Arg His Gly Trp Arg Thr Gly Ala Ile Ile Pro Glu Leu Glu Arg
370 375 380
Glu Ile Arg Ile Ile Asn Thr Glu Gln Tyr Met His Ser Leu Thr Trp
385 390 395 400
Gln Gln Ala Leu Thr Gly Leu Leu Glu Arg Met Gln Thr Tyr Gln Asp
405 410 415
Ala Glu Ser Arg Gln Val Leu Ala Ala Trp Met Lys Glu Arg Gln Glu
420 425 430
Leu Arg Cys Ile Thr Lys Ala Leu Phe Asn Ala Gln Phe Gly Ser Ile
435 440 445
Phe Arg Thr Phe His Asn Pro Thr Tyr Phe Ser Arg Arg Leu Val Arg
450 455 460
Phe Ser Asp Leu Tyr Met Ala Ser Leu Ser Cys Leu Leu Asn Tyr Arg
465 470 475 480
Val Asp Phe Thr Phe Tyr Pro Arg Arg Thr Pro Leu Gln His Glu Ala
485 490 495
Pro Leu Trp Met Asp Gln Leu Cys Thr Gly Cys Met Lys Thr Pro Phe
500 505 510
Leu Gly Asp Met Ala His Ile Arg
515 520
<210>135
<211>322
<212>PRT
<213>人
<400>135
Met Ala Arg Cys Phe Ser Leu Val Leu Leu Leu Thr Ser Ile Trp Thr
1 5 10 15
Thr Arg Leu Leu Val Gln Gly Ser Leu Arg Ala Glu Glu Leu Ser Ile
20 25 30
Gln Val Ser Cys Arg Ile Met Gly Ile Thr Leu Val Ser Lys Lys Ala
35 40 45
Asn Gln Gln Leu Asn Phe Thr Glu Ala Lys Glu Ala Cys Arg Leu Leu
50 55 60
Gly Leu Ser Leu Ala Gly Lys Asp Gln Val Glu Thr Ala Leu Lys Ala
65 70 75 80
Ser Phe Glu Thr Cys Ser Tyr Gly Trp Val Gly Asp Gly Phe Val Val
85 90 95
Ile Ser Arg Ile Ser Pro Asn Pro Lys Cys Gly Lys Asn Gly Val Gly
100 105 110
Val Leu ILe Trp Lys Val Pro Val Ser Arg Gln Phe Ala Ala Tyr Cys
115 120 125
Tyr Asn Ser Ser Asp Thr Trp Thr Asn Ser Cys Ile Pro Glu Ile Ile
130 135 140
Thr Thr Lys Asp Pro Ile Phe Asn Thr Gln Thr Ala Thr Gln Thr Thr
145 150 155 160
Glu Phe Ile Val Ser Asp Ser Thr Tyr Ser Val Ala Ser Pro Tyr Ser
165 170 175
Thr Ile Pro Ala Pro Thr Thr Thr Pro Pro Ala Pro Ala Ser Thr Ser
180 185 190
Ile Pro Arg Arg Lys Lys Leu Ile Cys Val Thr Glu Val Phe Met Glu
195 200 205
Thr Ser Thr Met Ser Thr Glu Thr Glu Pro Phe Val Glu Asn Lys Ala
210 215 220
Ala Phe Lys Asn Glu Ala Ala Gly Phe Gly Gly Val Pro Thr Ala Leu
225 230 235 240
Leu Val Leu Ala Leu Leu Phe Phe Gly Ala Ala Ala Gly Leu Gly Phe
245 250 255
Cys Tyr Val Lys Arg Tyr Val Lys Ala Phe Pro Phe Thr Asn Lys Asn
260 265 270
Gln Gln Lys Glu Met Ile Glu Thr Lys Val Val Lys Glu Glu Lys Ala
275 280 285
Asn Asp Ser Asn Pro Asn Glu Glu Ser Lys Lys Thr Asp Lys Asn Pro
290 295 300
Glu Glu Ser Lys Ser Pro Ser Lys Thr Thr Val Arg Cys Leu Glu Ala
305 310 315 320
Glu Val
<210>136
<211>1202
<212>PRT
<213>人
<400>136
Met Gly Arg Glu Gln Asp Leu Ile Leu Ala Val Lys Asn Gly Asp Val
1 5 10 15
Thr Gly Val Gln Lys Leu Val Ala Lys Val Lys Ala Thr Lys Thr Lys
20 25 30
Leu Leu Gly Ser Thr Lys Arg Leu Asn Val Asn Tyr Gln Asp Ala Asp
35 40 45
Gly Phe Ser Ala Leu His His Ala Ala Leu Gly Gly Ser Leu Glu Leu
50 55 60
Ile Ala Leu Leu Leu Glu Ala Gln Ala Thr Val Asp Ile Lys Asp Ser
65 70 75 80
Asn Gly Met Arg Pro Leu His Tyr Ala Ala Trp Gln Gly Arg Leu Glu
85 90 95
Pro Val Arg Leu Leu Leu Arg Ala Ser Ala Ala Val Asn Ala Ala Ser
100 105 110
Leu Asp Gly Gln Ile Pro Leu His Leu Ala Ala Gln Tyr Gly His Tyr
115 120 125
Glu Val Ser Glu Met Leu Leu Gln His Gln Ser Asn Pro Cys Leu Val
130 135 140
Asn Lys Ala Lys Lys Thr Pro Leu Asp Leu Ala Cys Glu Phe Gly Arg
145 150 155 160
Leu Lys ValAla Gln Leu Leu Leu Asn Ser His Leu Cys Val Ala Leu
165 170 175
Leu Glu Gly Glu Ala Lys Asp Pro Cys Asp Pro Asn Tyr Thr Thr Pro
180 185 190
Leu His Leu Ala Ala Lys Asn Gly His Arg Glu Val Ile Arg Gln Leu
195 200 205
Leu Arg Ala Gly Ile Glu Ile Asn Arg Gln Thr Lys Thr Gly Thr Ala
210 215 220
Leu His Glu Ala Ala Leu Tyr Gly Lys Thr Glu Val Val Arg Leu Leu
225 230 235 240
Leu Glu Gly Gly Val Asp Val Asn Ile Arg Asn Thr Tyr Asn Gln Thr
245 250 255
Ala Leu Asp Ile Val Asn Gln Phe Thr Thr Ser Gln Ala Ser Arg Glu
260 265 270
Ile Lys Gln Leu Leu Arg Glu Ala Ser Gly Ile Leu Lys Val Arg Ala
275 280 285
Leu Lys Asp Phe Trp Asn Leu His Asp Pro Thr Ala Leu Asn Val Arg
290 295 300
Ala Gly Asp Val Ile Thr Val Leu Glu Gln His Pro Asp Gly Arg Trp
305 310 315 320
Lys Gly His Ile His Glu Ser Gln Arg Gly Thr Asp Arg Ile Gly Tyr
325 330 335
Phe Pro Pro Gly Ile Val Glu Val Val Ser Lys Arg Val Gly Ile Pro
340 345 350
Ala Ala Arg Leu Pro Ser Ala Pro Thr Pro Leu Arg Pro Gly Phe Ser
355 360 365
Arg Thr Pro Gln Pro Pro Ala Glu Glu Pro Pro His Pro Leu Thr Tyr
370 375 380
Ser Gln Leu Pro Arg Val Gly Leu Ser Pro Asp Ser Pro Ala Gly Asp
385 390 395 400
Arg Asn Ser Val Gly Ser Glu Gly Ser Val Gly Ser Ile Arg Ser Ala
405 410 415
Gly Ser Gly Gln Ser Ser Glu Gly Thr Asn Gly His Gly Pro Gly Leu
420 425 430
Leu Ile Glu Asn Ala Gln Pro Leu Pro Ser Ala Gly Glu Asp Gln Val
435 440 445
Leu Pro Gly Leu His Pro Pro Ser Leu Ala Asp Asn Leu Ser His Arg
450 455 460
Pro Leu Ala Asn Cys Arg Ser Gly Glu Gln Ile Phe Thr Gln Asp Val
465 470 475 480
Arg Pro Glu Gln Leu Leu Glu Gly Lys Asp Ala Gln Ala Ile His Asn
485 490 495
Trp Leu Ser Glu Phe Gln Leu Glu Gly Tyr Thr Ala His Phe Leu Gln
500 505 510
Ala Gly Tyr Asp Val Pro Thr Ile Ser Arg Met Thr Pro Glu Asp Leu
515 520 525
Thr Ala Ile Gly Val Thr Lys Pro Gly His Arg Lys Lys Ile Ala Ser
530 535 540
Glu Ile Ala Gln Leu Ser Ile Ala Glu Trp Leu Pro Ser Tyr Ile Pro
545 550 555 560
Thr Asp Leu Leu Glu Trp Leu Cys Ala Leu Gly Leu Pro Gln Tyr His
565 570 575
Lys Gln Leu Val Ser Ser Gly Tyr Asp Ser Met Gly Leu Val Ala Asp
580 585 590
Leu Thr Trp Glu Glu Leu Gln Glu Ile Gly Val Asn Lys Leu Gly His
595 600 605
Gln Lys Lys Leu Met Leu Gly Val Lys Arg Leu Ala Glu Leu Arg Arg
610 615 620
Gly Leu Leu Gln Gly Glu Ala Leu Ser Glu Gly Gly Arg Arg Leu Ala
625 630 635 640
Lys Gly Pro Glu Leu Met Ala Ile Glu Gly Leu Glu Asn Gly Glu Gly
645 650 655
Pro Ala Thr Ala Gly Pro Arg Leu Leu Thr Phe Gln Gly Ser Glu Leu
660 665 670
Ser Pro Glu Leu Gln Ala Ala Met Ala Gly Gly Gly Pro Glu Pro Leu
675 680 685
Pro Leu Pro Pro Ala Arg Ser Pro Ser Gln Glu Ser Ile Gly Ala Arg
690 695 700
Ser Arg Gly Ser Gly His Ser Gln Glu Gln Pro Ala Pro Gln Pro Ser
705 710 715 720
Gly Gly Asp Pro Ser Pro Pro Gln Glu Arg Asn Leu Pro Glu Gly Thr
725 730 735
Glu Arg Pro Pro Lys Leu Cys Ser Ser Leu Pro Gly Gln Gly Pro Pro
740 745 750
Pro Tyr Val Phe Met Tyr Pro Gln Gly Ser Pro Ser Ser Pro Ala Pro
755 760 765
Gly Pro Pro Pro Gly Ala Pro Trp Ala Phe Ser Tyr Leu Ala Gly Pro
770 775 780
Pro Ala Thr Pro Pro Asp Pro Pro Arg Pro Lys Arg Arg Ser His Ser
785 790 795 800
Leu Ser Arg Pro Gly Pro Thr Glu Gly Asp Ala Glu Gly Glu Ala Glu
805 810 815
Gly Pro Val Gly Ser Thr Leu Gly Ser Tyr Ala Thr Leu Thr Arg Arg
820 825 830
Pro Gly Arg Ser Ala Leu Val Arg Thr Ser Pro Ser ValThr Pro Thr
835 840 845
Pro Ala Arg Gly Thr Pro Arg Ser Gln Ser Phe Ala Leu Arg Ala Arg
850 855 860
Arg Lys Gly Pro Pro Pro Pro Pro Pro Lys Arg Leu Ser Ser Val Ser
865 870 875 880
Gly Pro Ser Pro Glu Pro Pro Pro Leu Asp Gly Ser Pro Gly Pro Lys
885 890 895
Glu Gly Ala Thr Gly Pro Arg Arg Arg Thr Leu Ser Glu Pro Ala Gly
900 905 910
Pro Ser Glu Pro Pro Gly Pro Pro Ala Pro Ala Gly Pro Ala Ser Asp
915 920 925
Thr Glu Glu Glu Glu Pro Gly Pro Glu Gly Thr Pro Pro Ser Arg Gly
930 935 940
Ser Ser Gly Glu Gly Leu Pro Phe Ala Glu Glu Gly Asn Leu Thr Ile
945 950 955 960
Lys Gln Arg Pro Lys Pro Ala Gly Pro Pro Pro Arg Glu Thr Pro Val
965 970 975
Pro Pro Gly Leu Asp Phe Asn Leu Thr Glu Ser Asp Thr Val Lys Arg
980 985 990
Arg Pro Lys Cys Arg Glu Arg Glu Pro Leu Gln Thr Ala Leu Leu Ala
995 1000 1005
Phe Gly Val Ala Ser Ala Thr Pro Gly Pro Ala Ala Pro Leu Pro
1010 1015 1020
Ser Pro Thr Pro Gly Glu Ser Pro Pro Ala Ser Ser Leu Pro Gln
1025 1030 1035
Pro Glu Pro Ser Ser Leu Pro Ala Gln Gly Val Pro Thr Pro Leu
1040 1045 1050
Ala Pro Ser Pro Ala Met Gln Pro Pro Val Pro Pro Cys Pro Gly
1055 1060 1065
Pro Gly Leu Glu Ser Ser Ala Ala Ser Arg Trp Asn Gly Glu Thr
1070 1075 1080
Glu Pro Pro Ala Ala Pro Ala Ala Leu Leu Lys Val Pro Gly Ala
1085 1090 1095
Gly Thr Ala Pro Lys Pro Val Ser Val Ala Cys Thr Gln Leu Ala
1100 1105 1110
Phe Ser Gly Pro Lys Leu Ala Pro Arg Leu Gly Pro Arg Pro Val
1115 1120 1125
Pro Pro Pro Arg Pro Glu Ser Thr Gly Thr Val Gly Pro Gly Gln
1130 1135 1140
Ala Gln Gln Arg Leu Glu Gln Thr Ser Ser Ser Leu Ala Ala Ala
1145 1150 1155
Leu Arg Ala Ala Glu Lys Ser Ile Gly Thr Lys Glu Gln Glu Gly
1160 1165 1170
Thr Pro Ser Ala Ser Thr Lys His Ile Leu Asp Asp Ile Ser Thr
1175 1180 1185
Met Phe Asp Ala Leu Ala Asp Gln Leu Asp Ala Met Leu Asp
1190 1195 1200
<210>137
<211>1496
<212>PRT
<213>人
<400>137
Met Met Ala Asn Trp Ala Glu Ala Arg Pro Leu Leu Ile Leu Ile Val
1 5 10 15
Leu Leu Gly Gln Phe Val Ser Ile Lys Ala Gln Glu Glu Asp Glu Asp
20 25 30
Glu Gly Tyr Gly Glu Glu Ile Ala Cys Thr Gln Asn Gly Gln Met Tyr
35 40 45
Leu Asn Arg Asp Ile Trp Lys Pro Ala Pro Cys Gln Ile Cys ValCys
50 55 60
Asp Asn Gly Ala Ile Leu Cys Asp Lys Ile Glu Cys Gln Asp Val Leu
65 70 75 80
Asp Cys Ala Asp Pro Val Thr Pro Pro Gly Glu Cys Cys Pro Val Cys
85 90 95
Ser Gln Thr Pro Gly Gly Gly Asn Thr Asn Phe Gly Arg Gly Arg Lys
100 105 110
Gly Gln Lys Gly Glu Pro Gly Leu Val Pro Val ValThr Gly Ile Arg
115 120 125
Gly Arg Pro Gly Pro Ala Gly Pro Pro Gly Ser Gln Gly Pro Arg Gly
130 135 140
Glu Arg Gly Pro Lys Gly Arg Pro Gly Pro Arg Gly Pro Gln Gly Ile
145 150 155 160
Asp Gly Glu Pro Gly Val Pro Gly Gln Pro Gly Ala Pro Gly Pro Pro
165 170 175
Gly His Pro Ser His Pro Gly Pro Asp Gly Leu Ser Arg Pro Phe Ser
180 185 190
Ala Gln Met Ala Gly Leu Asp Glu Lys Ser Gly Leu Gly Ser Gln Val
195 200 205
Gly Leu Met Pro Gly Ser Val Gly Pro Val Gly Pro Arg Gly Pro Gln
210 215 220
Gly Leu Gln Gly Gln Gln Gly Gly Ala Gly Pro Thr Gly Pro Pro Gly
225 230 235 240
Glu Pro Gly Asp Pro Gly Pro Met Gly ProIle Gly Ser Arg Gly Pro
245 250 255
Glu Gly Pro Pro Gly Lys Pro Gly Glu Asp Gly Glu Pro Gly Arg Asn
260 265 270
Gly Asn Pro Gly Glu Val Gly Phe Ala Gly Ser Pro Gly Ala Arg Gly
275 280 285
Phe Pro Gly Ala Pro Gly Leu Pro Gly Leu Lys Gly His Arg Gly His
290 295 300
Lys Gly Leu Glu Gly Pro Lys Gly Glu Val Gly Ala Pro Gly Ser Lys
305 310 315 320
Gly Glu Ala Gly Pro Thr Gly Pro Met Gly Ala Met Gly Pro Leu Gly
325 330 335
Pro Arg Gly Met Pro Gly Glu Arg Gly Arg Leu Gly Pro Gln Gly Ala
340 345 350
Pro Gly Gln Arg Gly Ala His Gly Met Pro Gly Lys Pro Gly Pro Met
355 360 365
Gly Pro Leu Gly Ile Pro Gly Ser Ser Gly Phe Pro Gly Asn Pro Gly
370 375 380
Met Lys Gly Glu Ala Gly Pro Thr Gly Ala Arg Gly Pro Glu Gly Pro
385 390 395 400
Gln Gly Gln Arg Gly Glu Thr Gly Pro Pro Gly Pro Val Gly Ser Pro
405 410 415
Gly Leu Pro Gly Ala Ile Gly Thr Asp Gly Thr Pro Gly Pro Lys Gly
420 425 430
Pro Thr Gly Ser Pro Gly Thr Ser Gly Pro Pro Gly Ser Ala Gly Pro
435 440 445
Pro Gly Ser Pro Gly Pro Gln Gly Ser Thr Gly Pro Gln Gly Asn Ser
450 455 460
Gly Leu Pro Gly Asp Pro Gly Phe Lys Gly Glu Ala Gly Pro Lys Gly
465 470 475 480
Glu Pro Gly Pro His Gly Ile Gln Gly Pro Ile Gly Pro Pro Gly Glu
485 490 495
Glu Gly Lys Arg Gly Pro Arg Gly Asp Pro Gly Thr Leu Gly Pro Pro
500 505 510
Gly Pro Val Gly Glu Arg Gly Ala Pro Gly Asn Arg Gly Phe Pro Gly
515 520 525
Ser Asp Gly Leu Pro Gly Pro Lys Gly Ala Gln Gly Glu Arg Gly Pro
530 535 540
Val Gly Ser Ser Gly Pro Lys Gly Ser Gln Gly Asp Pro Gly Arg Pro
545 550 555 560
Gly Glu Pro Gly Leu Pro Gly Ala Arg Gly Leu Thr Gly Asn Pro Gly
565 570 575
Val Gln Gly Pro Glu Gly Lys Leu Gly Pro Leu Gly Ala Pro Gly Glu
580 585 590
Asp Gly Arg Pro Gly Pro Pro Gly Ser Ile Gly Ile Lys Gly Gln Pro
595 600 605
Gly Thr Met Gly Leu Pro Gly Pro Lys Gly Ser Asn Gly Asp Pro Gly
610 615 620
Lys Pro Gly Glu Ala Gly Asn Pro Gly Val Pro Gly Gln Arg Gly Ala
625 630 635 640
Pro Gly Lys Asp Gly Lys Val Gly Pro Tyr Gly Pro Pro Gly Pro Pro
645 650 655
Gly Leu Arg Gly Glu Arg Gly Glu Gln Gly Pro Pro Gly Pro Thr Gly
660 665 670
Phe Gln Gly His Pro Gly Pro Pro Gly Pro Pro Gly Glu Gly Gly Lys
675 680 685
Pro Gly Asp Gln Gly Val Pro Gly Gly Pro Gly Ala Val Gly Pro Leu
690 695 700
Gly Pro Arg Gly Glu Arg Gly Asn Pro Gly Glu Arg Gly Glu Pro Gly
705 710 715 720
Ile Thr Gly Leu Pro Gly Glu Lys Gly Met Ala Gly Gly His Gly Pro
725 730 735
Asp Gly Pro Lys Gly Ser Pro Gly Pro Ser Gly Thr Pro Gly Asp Thr
740 745 750
Gly Pro Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ile Ala Gly
755 760 765
Thr Pro Gly Pro Lys Gly Asp Arg Gly Gly Ile Gly Glu Lys Gly Ala
770 775 780
Glu Gly Thr Ala Gly Asn Asp Gly Ala Gly Gly Leu Pro Gly Pro Leu
785 790 795 800
Gly Pro Pro Gly Pro Ala Gly Leu Leu Gly Glu Lys Gly Glu Pro Gly
805 810 815
Pro Arg Gly Leu Val Gly Pro Pro Gly Ser Arg Gly Asn Pro Gly Ser
820 825 830
Arg Gly Glu Asn Gly Pro Thr Gly Ala Val Gly Phe Ala Gly Pro Gln
835 840 845
Gly Ser Asp Gly Gln Pro Gly ValLys Gly Glu Pro Gly Glu Pro Gly
850 855 860
Gln Lys Gly Asp Ala Gly Ser Pro Gly Pro Gln Gly Leu Ala Gly Ser
865 870 875 880
Pro Gly Pro His Gly Pro Asn Gly Val Pro Gly Leu Lys Gly Gly Arg
885 890 895
Gly Thr Gln Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ser Ala Gly
900 905 910
Arg Val Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Ala Gly Pro
915 920 925
Leu Gly Glu Pro Gly Lys Glu Gly Pro Pro Gly Pro Arg Gly Asp Pro
930 935 940
Gly Ser His Gly Arg Val Gly Val Arg Gly Pro Ala Gly Pro Pro Gly
945 950 955 960
Gly Pro Gly Asp Lys Gly Asp Pro Gly Glu Asp Gly Gln Pro Gly Pro
965 970 975
Asp Gly Pro Pro Gly Pro Ala Gly Thr Thr Gly Gln Arg Gly Ile Val
980 985 990
Gly Met Pro Gly Gln Arg Gly Glu Arg Gly Met Pro Gly Leu Pro Gly
995 1000 1005
Pro Ala Gly Thr Pro Gly Lys Val Gly Pro Thr Gly Ala Thr Gly
1010 1015 1020
Asp Lys Gly Pro Pro Gly Pro Val Gly Pro Pro Gly Ser Asn Gly
1025 1030 1035
Pro Val Gly Glu Pro Gly Pro Glu Gly Pro Ala Gly Asn Asp Gly
1040 1045 1050
Thr Pro Gly Arg Asp Gly Ala Val Gly Glu Arg Gly Asp Arg Gly
1055 1060 1065
Asp Pro Gly Pro Ala Gly Leu Pro Gly Ser Gln Gly Ala Pro Gly
1070 1075 1080
Thr Pro Gly Pro Val Gly Ala Pro Gly Asp Ala Gly Gln Arg Gly
1085 1090 1095
Asp Pro Gly Ser Arg Gly Pro Ile Gly His Leu Gly Arg Ala Gly
1100 1105 1110
Lys Arg Gly Leu Pro Gly Pro Gln Gly Pro Arg Gly Asp Lys Gly
1115 1120 1125
Asp His Gly Asp Arg Gly Asp Arg Gly Gln Lys Gly His Arg Gly
1130 1135 1140
Phe Thr Gly Leu Gln Gly Leu Pro Gly Pro Pro Gly Pro Asn Gly
1145 1150 1155
Glu Gln Gly Ser Ala Gly Ile Pro Gly Pro Phe Gly Pro Arg Gly
1160 1165 1170
Pro Pro Gly Pro Val Gly Pro Ser Gly Lys Glu Gly Asn Pro Gly
1175 1180 1185
Pro Leu Gly Pro Leu Gly Pro Pro Gly Val Arg Gly Ser Val Gly
1190 1195 1200
Glu Ala Gly Pro Glu Gly Pro Pro Gly Glu Pro Gly Pro Pro Gly
1205 1210 1215
Pro Pro Gly Pro Pro Gly His Leu Thr Ala Ala Leu Gly Asp Ile
1220 1225 1230
Met Gly His Tyr Asp Glu Ser Met Pro Asp Pro Leu Pro Glu Phe
1235 1240 1245
Thr Glu Asp Gln Ala Ala Pro Asp Asp Lys Asn Lys Thr Asp Pro
1250 1255 1260
Gly Val His Ala Thr Leu Lys Ser Leu Ser Ser Gln Ile Glu Thr
1265 1270 1275
Met Arg Ser Pro Asp Gly Ser Lys Lys His Pro Ala Arg Thr Cys
1280 1285 1290
Asp Asp Leu Lys Leu Cys His Ser Ala Lys Gln Ser Gly Glu Tyr
1295 1300 1305
Trp Ile Asp Pro Asn Gln Gly Ser ValGlu Asp Ala Ile Lys Val
1310 1315 1320
Tyr Cys Asn Met Glu Thr Gly Glu Thr Cys Ile Ser Ala Asn Pro
1325 1330 1335
Ser Ser Val Pro Arg Lys Thr Trp Trp Ala Ser Lys Ser Pro Asp
1340 1345 1350
Asn Lys Pro Val Trp Tyr Gly Leu Asp Met Asn Arg Gly Ser Gln
1355 1360 1365
Phe Ala Tyr Gly Asp His Gln Ser Pro Asn Thr Ala Ile Thr Gln
1370 1375 1380
Met Thr Phe Leu Arg Leu Leu Ser Lys Glu Ala Ser Gln Asn Ile
1385 1390 1395
Thr Tyr Ile Cys Lys Asn Ser Val Gly Tyr Met Asp Asp Gln Ala
1400 1405 1410
Lys Asn Leu Lys Lys Ala Val Val Leu Lys Gly Ala Asn Asp Leu
1415 1420 1425
Asp Ile Lys Ala Glu Gly Asn Ile Arg Phe Arg Tyr Ile Val Leu
1430 1435 1440
Gln Asp Thr Cys Ser Lys Arg Asn Gly Asn Val Gly Lys Thr Val
1445 1450 1455
Phe Glu Tyr Arg Thr Gln Asn Val Ala Arg Leu Pro Ile Ile Asp
1460 1465 1470
Leu Ala Pro Val Asp Val Gly Gly Thr Asp Gln Glu Phe Gly Val
1475 1480 1485
Glu Ile Gly Pro Val Cys Phe Val
1490 1495
<210>138
<211>726
<212>PRT
<213>人
<400>138
Met Ser Thr Ala Thr Thr Val Ala Pro Ala Gly Ile Pro Ala Thr Pro
1 5 10 15
Gly Pro Val Asn Pro Pro Pro Pro Glu Val Ser Asn Pro Ser Lys Pro
20 25 30
Gly Arg Lys Thr Asn Gln Leu Gln Tyr Met Gln Asn Val Val Val Lys
35 40 45
Thr Leu Trp Lys His Gln Phe Ala Trp Pro Phe Tyr Gln Pro Val Asp
50 55 60
Ala Ile Lys Leu Asn Leu Pro Asp Tyr His LysIle Ile Lys Asn Pro
65 70 75 80
Met Asp Met Gly Thr Ile Lys Lys Arg Leu Glu Asn Asn Tyr Tyr Trp
85 90 95
Ser Ala Ser Glu Cys Met Gln Asp Phe Asn Thr Met Phe Thr Asn Cys
100 105 110
Tyr Ile Tyr Asn Lys Pro Thr Asp Asp Ile Val Leu Met Ala Gln Ala
115 120 125
Leu Glu Lys Ile Phe Leu Gln Lys Val Ala Gln Met Pro Gln Glu Glu
130 135 140
Val Glu Leu Leu Pro Pro Ala Pro Lys Gly Lys Gly Arg Lys Pro Ala
145 150 155 160
Ala Gly Ala Gln Ser Ala Gly Thr Gln Gln Val Ala Ala Val Ser Ser
165 170 175
Val Ser Pro Ala Thr Pro Phe Gln Ser Val Pro Pro Thr Val Ser Gln
180 185 190
Thr Pro Val Ile Ala Ala Thr Pro Val Pro Thr Ile Thr Ala Asn Val
195 200 205
Thr Ser Val Pro Val Pro Pro Ala Ala Ala Pro Pro Pro Pro Ala Thr
210 215 220
Pro Ile Val Pro Val Val Pro Pro Thr Pro Pro Val Val Lys Lys Lys
225 230 235 240
Gly Val Lys Arg Lys Ala Asp Thr Thr Thr Pro Thr Thr Ser Ala Ile
245 250 255
Thr Ala Ser Arg Ser Glu Ser Pro Pro Pro Leu Ser Asp Pro Lys Gln
260 265 270
Ala Lys Val Val Ala Arg Arg Glu Ser Gly Gly Arg Pro Ile Lys Pro
275 280 285
Pro Lys Lys Asp Leu Glu Asp Gly Glu Val Pro Gln His Ala Gly Lys
290 295 300
Lys Gly Lys Leu Ser Glu His Leu Arg Tyr Cys Asp Ser Ile Leu Arg
305 310 315 320
Glu Met Leu Ser Lys Lys His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys
325 330 335
Pro Val Asp Ala Glu Ala Leu Glu Leu His Asp Tyr His Asp Ile Ile
340 345 350
Lys His Pro Met Asp Leu Ser Thr Val Lys Arg Lys Met Asp Gly Arg
355 360 365
Glu Tyr Pro Asp Ala Gln Gly Phe Ala Ala Asp Val Arg Leu Met Phe
370 375 380
Ser Asn Cys Tyr Lys Tyr Asn Pro Pro Asp His Glu Val Val Ala Met
385 390 395 400
Ala Arg Lys Leu Gln Asp Val Phe Glu Met Arg Phe Ala Lys Met Pro
405 410 415
Asp Glu Pro Val Glu Ala Pro Ala Leu Pro Ala Pro Ala Ala Pro Met
420 425 430
Val Ser Lys Gly Ala Glu Ser Ser Arg Ser Ser Glu Glu Ser Ser Ser
435 440 445
Asp Ser Gly Ser Ser Asp Ser Glu Glu Glu Arg Ala Thr Arg Leu Ala
450 455 460
Glu Leu Gln Glu Gln Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu
465 470 475 480
Ser Gln Ala Pro Val Asn Lys Pro Lys Lys Lys Lys Glu Lys Lys Glu
485 490 495
Lys Glu Lys Lys Lys Lys Asp Lys Glu Lys Glu Lys Glu Lys His Lys
500 505 510
Val Lys Ala Glu Glu Glu Lys Lys Ala Lys Val Ala Pro Pro Ala Lys
515 520 525
Gln Ala Gln Gln Lys Lys Ala Pro Ala Lys Lys Ala Asn Ser Thr Thr
530 535 540
Thr Ala Gly Arg Gln Leu Lys Lys Gly Gly Lys Gln Ala Ser Ala Ser
545 550 555 560
Tyr Asp Ser Glu Glu Glu Glu Glu Gly Leu Pro Met Ser Tyr Asp Glu
565 570 575
Lys Arg Gln Leu Ser Leu Asp Ile Asn Arg Leu Pro Gly Glu Lys Leu
580 585 590
Gly Arg Val Val His Ile Ile Gln Ser Arg Glu Pro Ser Leu Arg Asp
595 600 605
Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe Glu Thr Leu Lys Pro Thr
610 615 620
Thr Leu Arg Glu Leu Glu Arg Tyr Val Lys Ser Cys Leu Gln Lys Lys
625 630 635 640
Gln Arg Lys Pro Phe Ser Ala Ser Gly Lys Lys Gln Ala Ala Lys Ser
645 650 655
Lys Glu Glu Leu Ala Gln Glu Lys Lys Lys Glu Leu Glu Lys Arg Leu
660 665 670
Gln Asp Val Ser Gly Gln Leu Ser Ser Ser Lys Lys Pro Ala Arg Lys
675 680 685
Glu Lys Pro Gly Ser Ala Pro Ser Gly Gly Pro Ser Arg Leu Ser Ser
690 695 700
Ser Ser Ser Ser Glu Ser Gly Ser Ser Ser Ser Ser Gly Ser Ser Ser
705 710 715 720
Asp Ser Ser Asp Ser Glu
725
<210>139
<211>840
<212>PRT
<213>人
<400>139
Met Ala Ser Val Phe Arg Ser Glu Glu Met Cys Leu Ser Gln Leu Phe
1 5 10 15
Leu Gln Val Glu Ala Ala Tyr Cys Cys Val Ala Glu Leu Gly Glu Leu
20 25 30
Gly Leu Val Gln Phe Lys Asp Leu Asn Met Asn Val Asn Ser Phe Gln
35 40 45
Arg Lys Phe Val Asn Glu Val Arg Arg Cys Glu Ser Leu Glu Arg Ile
50 55 60
Leu Arg Phe Leu Glu Asp Glu Met Gln Asn Glu Ile Val Val Gln Leu
65 70 75 80
Leu Glu Lys Ser Pro Leu Thr Pro Leu Pro Arg Glu Met Ile Thr Leu
85 90 95
Glu Thr Val Leu Glu Lys Leu Glu Gly Glu Leu Gln Glu Ala Asn Gln
100 105 110
Asn Gln Gln Ala Leu Lys Gln Ser Phe Leu Glu Leu Thr Glu Leu Lys
115 120 125
Tyr Leu Leu Lys Lys Thr Gln Asp Phe Phe Glu Thr Glu Thr Asn Leu
130 135 140
Ala Asp Asp Phe Phe Thr Glu Asp Thr Ser Gly Leu Leu Glu Leu Lys
145 150 155 160
Ala Val Pro Ala Tyr Met Thr Gly Lys Leu Gly Phe Ile Ala Gly Val
165 170 175
Ile Asn Arg Glu Arg Met Ala Ser Phe Glu Arg Leu Leu Trp Arg Ile
180 185 190
Cys Arg Gly Asn Val Tyr Leu Lys Phe Ser Glu Met Asp Ala Pro Leu
195 200 205
Glu Asp Pro Val Thr Lys Glu Glu Ile Gln Lys Asn Ile Phe Ile Ile
210 215 220
Phe Tyr Gln Gly Glu Gln Leu Arg Gln Lys Ile Lys Lys Ile Cys Asp
225 230 235 240
Gly Phe Arg Ala Thr Val Tyr Pro Cys Pro Glu Pro Ala Val Glu Arg
245 250 255
Arg Glu Met Leu Glu Ser Val Asn Val Arg Leu Glu Asp Leu Ile Thr
260 265 270
Val Ile Thr Gln Thr Glu Ser His Arg Gln Arg Leu Leu Gln Glu Ala
275 280 285
Ala Ala Asn Trp His Ser Trp Leu Ile Lys Val Gln Lys Met Lys Ala
290 295 300
Val Tyr His Ile Leu Asn Met Cys Asn Ile Asp Val Thr Gln Gln Cys
305 310 315 320
Val Ile Ala Glu Ile Trp Phe Pro Val Ala Asp Ala Thr Arg Ile Lys
325 330 335
Arg Ala Leu Glu Gln Gly Met Glu Leu Ser Gly Ser Ser Met Ala Pro
340 345 350
Ile Met Thr Thr Val Gln Ser Lys Thr Ala Pro Pro Thr Phe Asn Arg
355 360 365
Thr Asn Lys Phe Thr Ala Gly Phe Gln Asn Ile Val Asp Ala Tyr Gly
370 375 380
Val Gly Ser Tyr Arg Glu Ile Asn Pro Ala Pro Tyr Thr Ile Ile Thr
385 390 395 400
Phe Pro Phe Leu Phe Ala Val Met Phe Gly Asp Cys Gly His Gly Thr
405 410 415
Val Met Leu Leu Ala Ala Leu Trp Met Ile Leu Asn Glu Arg Arg Leu
420 425 430
Leu Ser Gln Lys Thr Asp Asn Glu Ile Trp Asn Thr Phe Phe His Gly
435 440 445
Arg Tyr Leu Ile Leu Leu Met Gly Ile Phe Ser Ile Tyr Thr Gly Leu
450 455 460
Ile Tyr Asn Asp Cys Phe Ser Lys Ser Leu Asn Ile Phe Gly Ser Ser
465 470 475 480
Trp Ser Val Gln Pro Met Phe Arg Asn Gly Thr Trp Asn Thr His Val
485 490 495
Met Glu Glu Ser Leu Tyr Leu Gln Leu Asp Pro Ala Ile Pro Gly Val
500 505 510
Tyr Phe Gly Asn Pro Tyr Pro Phe Gly Ile Asp Pro Ile Trp Asn Leu
515 520 525
Ala Ser Asn Lys Leu Thr Phe Leu Asn Ser Tyr Lys Met Lys Met Ser
530 535 540
Val Ile Leu Gly Ile Val Gln Met Val Phe Gly Val Ile Leu Ser Leu
545 550 555 560
Phe Asn His Ile Tyr Phe Arg Arg Thr Leu Asn Ile Ile Leu Gln Phe
565 570 575
Ile Pro Glu Met Ile Phe Ile Leu Cys Leu Phe Gly Tyr Leu Val Phe
580 585 590
Met Ile Ile Phe Lys Trp Cys Cys Phe Asp Val His Val Ser Gln His
595 600 605
Ala Pro Ser Ile Leu Ile His Phe Ile Asn Met Phe Leu Phe Asn Tyr
610 615 620
Ser Asp Ser Ser Asn Ala Pro Leu Tyr Lys His Gln Gln Glu Val Gln
625 630 635 640
Ser Phe Phe Val Val Met Ala Leu Ile Ser Val Pro Trp Met Leu Leu
645 650 655
Ile Lys Pro Phe Ile Leu Arg Ala Ser His Arg Lys Ser Gln Leu Gln
660 665 670
Ala Ser Arg Ile Gln Glu Asp Ala Thr Glu Asn Ile Glu Gly Asp Ser
675 680 685
Ser Ser Pro Ser Ser Arg Ser Gly Gln Arg Thr Ser Ala Asp Thr His
690 695 700
Gly Ala Leu Asp Asp His Gly Glu Glu Phe Asn Phe Gly Asp Val Phe
705 710 715 720
Val His Gln Ala Ile His Thr Ile Glu Tyr Cys Leu Gly Cys Ile Ser
725 730 735
Asn Thr Ala Ser Tyr Leu Arg Leu Trp Ala Leu Ser Leu Ala His Ala
740 745 750
Gln Leu Ser Glu Val Leu Trp Thr Met Val Met Asn Ser Gly Leu Gln
755 760 765
Thr Arg Gly Trp Gly Gly Ile Val Gly Val Phe Ile Ile Phe Ala Val
770 775 780
Phe Ala Val Leu Thr Val Ala Ile Leu Leu Ile Met Glu Gly Leu Ser
785 790 795 800
Ala Phe Leu His Ala Leu Arg Leu His Trp Val Glu Phe Gln Asn Lys
805 810 815
Phe Tyr Val Gly Asp Gly Tyr Lys Phe Ser Pro Phe Ser Phe Lys His
820 825 830
Ile Leu Asp Gly Thr Ala Glu Glu
835 840
<210>140
<211>826
<212>PRT
<213>人
<400>140
Pro Ser Gly Leu Pro Leu Leu Pro Val Leu Phe Ala Leu Gly Gly Leu
1 5 10 15
Leu Leu Leu Ser Asn Ala Ser Cys Val Gly Gly Val Leu Trp Gln Arg
20 25 30
Arg Leu Arg Arg Leu Ala Glu Ala Leu Asn Phe Pro Pro His Leu His
35 40 45
Pro Gly Arg Ser Glu Glu Asp Arg Val Arg Asn Glu Tyr Glu Glu Ser
50 55 60
Gln Trp Thr Gly Glu Arg Asp Thr Gln Ser Ser Thr Val Ser Thr Thr
65 70 75 80
Glu Ala Glu Pro Tyr Tyr Arg Ser Leu Arg Asp Phe Ser Pro Gln Leu
85 90 95
Pro Pro Thr Gln Glu Glu Val Ser Tyr Ser Arg Gly Phe Thr Gly Glu
100 105 110
Asp Glu Asp Met Ala Phe Pro Gly His Leu Tyr Asp Glu Val Glu Arg
115 120 125
Thr Tyr Pro Pro Ser Gly Ala Trp Gly Pro Leu Tyr Asp Glu Val Gln
130 135 140
Met Gly Pro Trp Asp Leu His Trp Pro Glu Asp Thr Tyr Gln Asp Pro
145 150 155 160
Arg Gly Ile Tyr Asp Gln Val Ala Gly Asp Leu Asp Thr Leu Glu Pro
165 170 175
Asp Ser Leu Pro Phe Glu Leu Arg Gly His Leu Val Trp Gly Phe Asn
180 185 190
His Val Ser Gln Ala Gly Leu Lys Leu Leu Ala Ser Ser Asp Pro Pro
195 200 205
Ala Ser Ala Ser Gln Ser Ala Glu Ile Thr Glu Ser His Ser Val Val
210 215 220
Gln Val Gly Val Gln Trp Arg Tyr Phe Gly Ser Leu His Pro Leu Pro
225 230 235 240
Pro Gly Ser Arg Asp Ser Leu Ala Ser Ala Ser Arg Ile Ala Gly Ile
245 250 255
Thr Ala Pro Trp Glu Ala Glu Val Ser Arg Ser Pro Gln Gly Thr Gln
260 265 270
Asp Ser Pro Val Thr Arg Ser Gly Pro Pro Ser Arg Gly Trp Gln Ser
275 280 285
Leu Ser Phe Asp Gly Gly Ala Phe His Leu Lys Gly Thr Gly Glu Leu
290 295 300
Thr Arg Ala Leu Leu Val Leu Arg Leu Cys Ala Trp Pro Pro Leu Val
305 310 315 320
Thr His Gly Leu Leu Leu Gln Ala Trp Ser Arg Arg Leu Leu Gly Ser
325 330 335
Arg Leu Ser Gly Ala Phe Leu Arg Ala Ser Val Tyr Gly Gln Phe Val
340 345 350
Ala Gly Glu Thr Ala Glu Glu Val Lys Gly Cys Val Gln Gln Leu Arg
355 360 365
Thr Leu Ser Leu Arg Pro Leu Leu Ala Val Pro Thr Glu Glu Glu Pro
370 375 380
Asp Ser Ala Ala Lys Arg Met Arg Leu His His Val Gly Gln Ala Gly
385 390 395 400
Leu Glu Leu Leu Thr Pro Ala Ala Ser Gly Ser Val Ala Gln Ala Gly
405 410 415
Val Gln Trp Arg Gln Ser Ser Asp Arg Gly Gly Gly Asn Gln Ala Ala
420 425 430
Ala Ser Arg Ser Ser Leu Leu Gln Glu Ala Ala Phe Ser Pro Pro Cys
435 440 445
Gly Arg Leu Gln Leu Pro Ala Gln Pro Ala Ser Arg His Gly Ala Arg
450 455 460
Gly Arg Gly Ser Met Lys Ala Lys Ser Leu Thr Ser Arg His Leu Leu
465 470 475 480
Ala Ser Gln Gly Gln Glu Thr Ile Ile Lys Thr Lys Val Arg Ile Pro
485 490 495
Ala Leu Trp Lys Ala Glu Pro Gly Gln His Ser Lys Thr Pro Ser Gln
500 505 510
Gln Asn Lys Ser Gln Tyr Val Thr Thr Leu Trp Glu Ala Asp Val Gly
515 520 525
Arg Ser Leu Glu Asn Leu Gln Val Ser Cys Leu Asn Ala Glu Gln Asn
530 535 540
Gln His Leu Arg Ala Ser Leu Ser Arg Leu His Arg Val Thr Pro Pro
545 550 555 560
Ala Gly Thr Ser Thr Ser Gly Pro Pro Ser Ala Ala Cys Ile Gly Trp
565 570 575
His Ser Arg Leu His Arg Val Ala Gln Tyr Ala Arg Ala Gln His Val
580 585 590
Arg Leu Leu Val Asp Ala Glu Tyr Thr Ser Leu Asn Pro Ala Leu Ser
595 600 605
Leu Leu Val Ala Ala Leu Ala Val Arg Trp Asn Ser Pro Gly Glu Gly
610 615 620
Gly Pro Trp Val Trp Asn Thr Tyr Gln Ala Cys Leu Lys Asp Thr Phe
625 630 635 640
Glu Arg Leu Gly Arg Asp Ala Glu Ala Ala His Arg Ala Gly Leu Ala
645 650 655
Phe Gly Val Lys Leu Val Arg Gly Ala Tyr Leu Asp Lys Glu Arg Ala
660 665 670
Val Ala Gln Leu His Gly Met Glu Asp Pro Thr Gln Pro Asp Tyr Glu
675 680 685
Ala Thr Ser Glu Leu Asn Arg Ala Ser Pro Phe Ser Tyr Ser Arg Cys
690 695 700
Leu Glu Leu Met Leu Thr His Val Ala Arg His Gly Pro Met Cys His
705 710 715 720
Leu Met Val Ala Ser His Asn Glu Glu Ser Val Arg Gln Ala Thr Lys
725 730 735
Arg Met Trp Glu Leu Gly Ile Pro Leu Asp Gly Thr Val Cys Phe Gly
740 745 750
Gln Leu Leu Gly Met Cys Asp His Val Ser Leu Ala Leu Gly Gln Ala
755 760 765
Gly Tyr Val Val Tyr Lys Ser Ile Pro Tyr Gly Ser Leu Glu Glu Val
770 775 780
Ile Pro Tyr Leu Ile Arg Arg Ala Gln Glu Asn Arg Ser Val Leu Gln
785 790 795 800
Gly Ala Arg Arg Glu Gln Glu Leu Leu Ser Gln Glu Leu Trp Arg Arg
805 810 815
Leu Leu Pro Gly Cys Arg Arg Ile Pro His
820 825
<210>141
<211>987
<212>PRT
<213>人
<400> 141
Met Ala Leu Arg Arg Leu Gly Ala Ala Leu Leu Leu Leu Pro Leu Leu
1 5 10 15
Ala Ala Val Glu Glu Thr Leu Met Asp Ser Thr Thr Ala Thr Ala Glu
20 25 30
Leu Gly Trp Met Val His Pro Pro Ser Gly Trp Glu Glu Val Ser Gly
35 40 45
Tyr Asp Glu Asn Met Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val
50 55 60
Phe Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Lys Phe Ile Arg Arg
65 70 75 80
Arg Gly Ala His Arg Ile His Val Glu Met Lys Phe Ser Val Arg Asp
85 90 95
Cys Ser Ser Ile Pro Ser Val Pro Gly Ser Cys Lys Glu Thr Phe Asn
100 105 110
Leu Tyr Tyr Tyr Glu Ala Asp Phe Asp Ser Ala Thr Lys Thr Phe Pro
115 120 125
Asn Trp Met Glu Asn Pro Trp Val Lys Val Asp Thr Ile Ala Ala Asp
130 135 140
Glu Ser Phe Ser Gln Val Asp Leu Gly Gly Arg Val Met Lys Ile Asn
145 150 155 160
Thr Glu ValArg Ser Phe Gly Pro Val Ser Arg Ser Gly Phe Tyr Leu
165 170 175
Ala Phe Gln Asp Tyr Gly Gly Cys Met Ser Leu Ile Ala Val Arg Val
180 185 190
Phe Tyr Arg Lys Cys Pro Arg Ile Ile Gln Asn Gly Ala Ile Phe Gln
195 200 205
Glu Thr Leu Ser Gly Ala Glu Ser Thr Ser Leu Val Ala Ala Arg Gly
210 215 220
Ser Cys Ile Ala Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr
225 230 235 240
Cys Asn Gly Asp Gly Glu Trp Leu Val Pro Ile Gly Arg Cys Met Cys
245 250 255
Lys Ala Gly Phe Glu Ala Val Glu Asn Gly Thr Val Cys Arg Gly Cys
260 265 270
Pro Ser Gly Thr Phe Lys Ala Asn Gln Gly Asp Glu Ala Cys Thr His
275 280 285
Cys Pro Ile Asn Ser Arg Thr Thr Ser Glu Gly Ala Thr Asn Cys Val
290 295 300
Cys Arg Asn Gly Tyr Tyr Arg Ala Asp Leu Asp Pro Leu Asp Met Pro
305 310 315 320
Cys Thr Thr Ile Pro Ser Ala Pro Gln Ala Val Ile Ser Ser Val Asn
325 330 335
Glu Thr Ser Leu Met Leu Glu Trp Thr Pro Pro Arg Asp Ser Gly Gly
340 345 350
Arg Glu Asp Leu Val Tyr Asn Ile Ile Cys Lys Ser Cys Gly Ser Gly
355 360 365
Arg Gly Ala Cys Thr Arg Cys Gly Asp Asn Val Gln Tyr Ala Pro Arg
370 375 380
Gln Leu Gly Leu Thr Glu Pro Arg Ile Tyr Ile Ser Asp Leu Leu Ala
385 390 395 400
His Thr Gln Tyr Thr Phe Glu Ile Gln Ala Val Asn Gly Val Thr Asp
405 410 415
Gln Ser Pro Phe Ser Pro Gln Phe Ala Ser Val Asn Ile Thr Thr Asn
420 425 430
Gln Ala Ala Pro Ser Ala Val Ser Ile Met His Gln Val Ser Arg Thr
435 440 445
Val Asp Ser Ile Thr Leu Ser Trp Ser Gln Pro Asp Gln Pro Asn Gly
450 455 460
Val Ile Leu Asp Tyr Glu Leu Gln Tyr Tyr Glu Lys Glu Leu Ser Glu
465 470 475 480
Tyr Asn Ala Thr Ala Ile Lys Ser Pro Thr Asn Thr Val Thr Val Gln
485 490 495
Gly Leu Lys Ala Gly Ala Ile Tyr Val Phe Gln Val Arg Ala Arg Thr
500 505 510
Val Ala Gly Tyr Gly Arg Tyr Ser Gly Lys Met Tyr Phe Gln Thr Met
515 520 525
Thr Glu Ala Glu Tyr Gln Thr Ser Ile Gln Glu Lys Leu Pro Leu Ile
530 535 540
Ile Gly Ser Ser Ala Ala Gly Leu ValPhe Leu Ile Ala Val Val Val
545 550 555 560
Ile Ala Ile Val Cys Asn Arg Arg Arg Gly Phe Glu Arg Ala Asp Ser
565 570 575
Glu Tyr Thr Asp Lys Leu Gln His Tyr Thr Ser Gly His Met Thr Pro
580 585 590
Gly Met Lys Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu
595 600 605
Ala Val Arg Glu Phe Ala Lys Glu Ile Asp Ile Ser Cys Val Lys Ile
610 615 620
Glu Gln Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly His
625 630 635 640
Leu Lys Leu Pro Gly Lys Arg Glu Ile Phe Val Ala Ile Lys Thr Leu
645 650 655
Lys Ser Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala
660 665 670
Ser Ile Met Gly Gln Phe Asp His Pro Asn Val Ile His Leu Glu Gly
675 680 685
Val Val Thr Lys Ser Thr Pro Val Met Ile Ile Thr Glu Phe Met Glu
690 695 700
Asn Gly Ser Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr
705 710 715 720
Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys
725 730 735
Tyr Leu Ala Asp Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn
740 745 750
Ile Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu
755 760 765
Ser Arg Phe Leu Glu Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ala
770 775 780
Leu Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Gln
785 790 795 800
Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val
805 810 815
Met Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Thr
820 825 830
Asn Gln Asp Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro
835 840 845
Pro Met Asp Cys Pro Ser Ala Leu His Gln Leu Met Leu Asp Cys Trp
850 855 860
Gln Lys Asp Arg Asn His Arg Pro Lys Phe Gly Gln Ile Val Asn Thr
865 870 875 880
Leu Asp Lys Met Ile Arg Asn Pro Asn Ser Leu Lys Ala Met Ala Pro
885 890 895
Leu Ser Ser Gly Ile Asn Leu Pro Leu Leu Asp Arg Thr Ile Pro Asp
900 905 910
Tyr Thr Ser Phe Asn Thr Val Asp Glu Trp Leu Glu Ala Ile Lys Met
915 920 925
Gly Gln Tyr Lys Glu Ser Phe Ala Asn Ala Gly Phe Thr Ser Phe Asp
930 935 940
Val Val Ser Gln Met Met Met Glu Asp Ile Leu Arg Val Gly Val Thr
945 950 955 960
Leu Ala Gly His Gln Lys Lys Ile Leu Asn Ser Ile Gln Val Met Arg
965 970 975
Ala Gln Met Asn Gln Ile Gln Ser Val Glu Val
980 985
<210>142
<211>379
<212>PRT
<213>人
<400>142
Met Val Phe Phe Thr Cys Asn Ala Cys Gly Glu Ser Val Lys Lys Ile
1 5 10 15
Gln Val Glu Lys His Val Ser Val Cys Arg Asn Cys Glu Cys Leu Ser
20 25 30
Cys Ile Asp Cys Gly Lys Asp Phe Trp Gly Asp Asp Tyr Lys Asn His
35 40 45
Val Lys Cys Ile Ser Glu Asp Gln Lys Tyr Gly Gly Lys Gly Tyr Glu
50 55 60
Gly Lys Thr His Lys Gly Asp Ile Lys Gln Gln Ala Trp Ile Gln Lys
65 70 75 80
Ile Ser Glu Leu Ile Lys Arg Pro Asn Val Ser Pro Lys Val Arg Glu
85 90 95
Leu Leu Glu Gln Ile Ser Ala Phe Asp Asn Val Pro Arg Lys Lys Ala
100 105 110
Lys Phe Gln Asn Trp Met Lys Asn Ser Leu Lys Val His Asn Glu Ser
115 120 125
Ile Leu Asp Gln Val Trp Asn Ile Phe Ser Glu Ala Ser Asn Ser Glu
130 135 140
Pro Val Asn Lys Glu Gln Asp Gln Arg Pro Leu His Pro Val Ala Asn
145 150 155 160
Pro His Ala Glu Ile Ser Thr Lys Val Pro Ala Ser Lys Val Lys Asp
165 170 175
Ala Val Glu Gln Gln Gly Glu Val Lys Lys Asn Lys Arg Glu Arg Lys
180 185 190
Glu Glu Arg Gln Lys Lys Arg Lys Arg Glu Lys Lys Glu Leu Lys Leu
195 200 205
Glu Asn His Gln Glu Asn Ser Arg Asn Gln Lys Pro Lys Lys Arg Lys
210 215 220
Lys Gly Gln Glu Ala Asp Leu Glu Ala Gly Gly Glu Glu Val Pro Glu
225 230 235 240
Ala Asn Gly Ser Ala Gly Lys Arg Ser Lys Lys Lys Lys Gln Arg Lys
245 250 255
Asp Ser Ala Ser Glu Glu Glu Ala Arg Val Gly Ala Gly Lys Arg Lys
260 265 170
Arg Arg His Ser Glu Val Glu Thr Asp Ser Lys Lys Lys Lys Met Lys
275 280 285
Leu Pro Glu His Pro Glu Gly Gly Glu Pro Glu Asp Asp Glu Ala Pro
290 295 300
Ala Lys Gly Lys Phe Asn Trp Lys Gly Thr Ile Lys Ala Ile Leu Lys
305 310 315 320
Gln Ala Pro Asp Asn Glu Ile Thr Ile Lys Lys Leu Arg Lys Lys Val
325 330 335
Leu Ala Gln Tyr Tyr Thr Val Thr Asp Glu His His Arg Ser Glu Glu
340 345 350
Glu Leu Leu Val Ile Phe Asn Lys Lys Ile Ser Lys Asn Pro Thr Phe
355 360 365
Lys Leu Leu Lys Asp Lys Val Lys Leu Val Lys
370 375
<210>143
<211>86
<212>PRT
<213>人
<400>143
Met Ala Glu Asp Met Glu Thr Lys Ile Lys Asn Tyr Lys Thr Ala Pro
1 5 10 15
Phe Asp Ser Arg Phe Pro Asn Gln Asn Gln Thr Arg Asn Cys Trp Gln
20 25 30
Asn Tyr Leu Asp Phe His Arg Cys Gln Lys Ala Met Thr Ala Lys Gly
35 40 45
Gly Asp Ile Ser Val Cys Glu Trp Tyr Gln Arg Val Tyr Gln Ser Leu
50 55 60
Cys Pro Thr Ser Trp Val Thr Asp Trp Asp Glu Gln Arg Ala Glu Gly
65 70 75 80
Thr Phe Pro Gly Lys Ile
85
<210>144
<211>166
<212>PRT
<213>人
<400>144
Met Leu Leu Ile Leu Leu Ser Val Ala Leu Leu Ala Phe Ser Ser Ala
1 5 10 15
Gln Asp Leu Asn Glu Asp Val Ser Gln Glu Asp Val Pro Leu Val Ile
20 25 30
Ser Asp Gly Gly Asp Ser Glu Gln Phe Ile Asp Glu Glu Arg Gln Gly
35 40 45
Pro Pro Leu Gly Gly Gln Gln Ser Gln Pro Ser Ala Gly Asp Gly Asn
50 55 60
Gln Asp Asp Gly Pro Gln Gln Gly Pro Pro Gln Gln Gly Gly Gln Gln
65 70 75 80
Gln Gln Gly Pro Pro Pro Pro Gln Gly Lys Pro Gln Gly Pro Pro Gln
85 90 95
Gln Gly Gly His Pro Pro Pro Pro Gln Gly Arg Pro Gln Gly Pro Pro
100 105 110
Gln Gln Gly Gly His Pro Arg Pro Pro Arg Gly Arg Pro Gln Gly Pro
115 120 125
Pro Gln Gln Gly Gly His Gln Gln Gly Pro Pro Pro Pro Pro Pro Gly
130 135 140
Lys Pro Gln Gly Pro Pro Pro Gln Gly Gly Arg Pro Gln Gly Pro Pro
145 150 155 160
Gln Gly Gln Ser Pro Gln
165
<210>145
<211>262
<212>PRT
<213>人
<400>145
Met Asp Pro Arg Leu Ser Thr Val Arg Gln Thr Cys Cys Cys Phe Asn
5 10 15
Val Arg Ile Ala Thr Thr Ala Leu Ala Ile Tyr His Val Ile Met Ser
20 25 30
Val Leu Leu Phe Ile Glu His Ser Val Glu Val Ala His Gly Lys Ala
35 40 45
Ser Cys Lys Leu Ser Gln Met Gly Tyr Leu Arg Ile Ala Asp Leu Ile
50 55 60
Ser Ser Phe Leu Leu Ile Thr Met Leu Phe Ile Ile Ser Leu Ser Leu
65 70 75 80
Leu Ile Gly Val Val Lys Asn Arg Glu Lys Tyr Leu Leu Pro Phe Leu
85 90 95
Ser Leu Gln Ile Met Asp Tyr Leu Leu Cys Leu Leu Thr Leu Leu Gly
100 105 110
Ser Tyr Ile Glu Leu Pro Ala Tyr Leu Lys Leu Ala Ser Arg Ser Arg
115 120 125
Ala Ser Ser Ser Lys Phe Pro Leu Met Thr Leu Gln Leu Leu Asp Phe
130 135 140
Cys Leu Ser Ile Leu Thr Leu Cys Ser Ser Tyr Met Glu Val Pro Thr
145 150 155 160
Tyr Leu Asn Phe Lys Ser Met Asn His Met Asn Tyr Leu Pro Ser Gln
165 170 175
Glu Asp Met Pro His Asn Gln Phe Ile Lys Met Met Ile Ile Phe Ser
180 185 190
Ile Ala Phe Ile Thr Val Leu Ile Phe Lys Val Tyr Met Phe Lys Cys
195 200 205
Val Trp Arg Cys Tyr Arg Leu Ile Lys Cys Met Asn Ser Val Glu Glu
210 215 220
Lys Arg Asn Ser Lys Met Leu Gln Lys Val Val Leu Pro Ser Tyr Glu
225 230 235 240
Glu Ala Leu Ser Leu Pro Ser Lys Thr Pro Glu Gly Gly Pro Ala Pro
245 250 255
Pro Pro Tyr Ser Glu Val
260
<210>146
<21l>772
<212>PRT
<213>人
<400>146
Met Gly Asp Glu Asp Asp Asp Glu Ser Cys Ala Val Glu Leu Arg Ile
l 5 10 15
Thr Glu Ala Asn Leu Thr Gly His Glu Glu Lys Val Ser Val Glu Asn
20 25 30
Phe Glu Leu Leu Lys Val Leu Gly Thr Gly Ala Tyr Gly Lys Val Phe
35 40 45
Leu Val Arg Lys Ala Gly Gly His Asp Ala Gly Lys Leu Tyr Ala Met
50 55 60
Lys Val Leu Arg Lys Ala Ala Leu Val Gln Arg Ala Lys Thr Gln Glu
65 70 75 80
His Thr Arg Thr Glu Arg Ser Val Leu Glu Leu Val Arg Gln Ala Pro
85 90 95
Phe Leu Val Thr Leu His Tyr Ala Phe Gln Thr Asp Ala Lys Leu His
100 105 110
Leu Ile Leu Asp Tyr Val Ser Gly Gly Glu Met Phe Thr His Leu Tyr
115 120 125
Gln Arg Gln Tyr Phe Lys Glu Ala Glu Val Arg Val Tyr Gly Gly Glu
130 135 140
Ile Val Leu Ala Leu Glu His Leu His Lys Leu Gly Ile Ile Tyr Arg
145 150 155 160
Asp Leu Lys Leu Glu Asn Val Leu Leu Asp Ser Glu Gly His Ile Val
165 170 175
Leu Thr Asp Phe Gly Leu Ser Lys Glu Phe Leu Thr Glu Glu Lys Glu
180 185 190
Arg Thr Phe Ser Phe Cys Gly Thr Ile Glu Tyr Met Ala Pro Glu Ile
195 200 205
Ile Arg Ser Lys Thr Gly His Gly Lys Ala Val Asp Trp Trp Ser Leu
210 215 220
Gly Ile Leu Leu Phe Glu Leu Leu Thr Gly Ala Ser Pro Phe Thr Leu
225 230 235 240
Glu Gly Glu Arg Asn Thr Gln Ala Glu Val Ser Arg Arg Ile Leu Lys
245 250 255
Cys Ser Pro Pro Phe Pro Pro Arg Ile Gly Pro Val Ala Gln Asp Leu
260 265 270
Leu Gln Arg Leu Leu Cys Lys Asp Pro Lys Lys Arg Leu Gly Ala Gly
275 280 285
Pro Gln Gly Ala Gln Glu Val Arg Asn His Pro Phe Phe Gln Gly Leu
290 295 300
Asp Trp Val Ala Leu Ala Ala Arg Lys Ile Pro Ala Pro Phe Arg Pro
305 3l0 315 320
Gln Ile Arg Ser Glu Leu Asp Val Gly Asn Phe Ala Glu Glu Phe Thr
325 330 335
Arg Leu Glu Pro Val Tyr Ser Pro Pro Gly Ser Pro Pro Pro Gly Asp
340 345 350
Pro Arg Ile Phe Gln Gly Tyr Ser Phe Val Ala Pro Ser Ile Leu Phe
355 360 365
Asp His Asn Asn Ala Val Met Thr Asp Gly Leu Glu Ala Pro Gly Ala
370 375 380
Gly Asp Arg Pro Gly Arg Ala Ala Val Ala Arg Ser Ala Met Met Gln
385 390 395 400
Asp Ser Pro Phe Phe Gln Gln Tyr Glu Leu Asp Leu Arg Glu Pro Ala
405 410 415
Leu Gly Gln Gly Ser Phe Ser Val Cys Arg Arg Cys Arg Gln Arg Gln
420 425 430
Ser Gly Gln Glu Phe Ala Val Lys Ile Leu Ser Arg Arg Leu Glu Ala
435 440 445
Asn Thr Gln Arg Glu Val Ala Ala Leu Arg Leu Cys Gln Ser His Pro
450 455 460
Asn Val Val Asn Leu His Glu Val His His Asp Gln Leu His Thr Tyr
465 470 475 480
Leu Val Leu Glu Leu Leu Arg Gly Gly Glu Leu Leu Glu His Ile Arg
485 490 495
Lys Lys Arg His Phe Ser Glu Ser Glu Ala Ser Gln Ile Leu Arg Ser
500 505 510
Leu Val Ser Ala Val Ser Phe Met His Glu Glu Ala Gly Val Val His
515 520 525
Arg Asp Leu Lys Pro Glu Asn Ile Leu Tyr Ala Asp Asp Thr Pro Gly
530 535 540
Ala Pro Val Lys Ile Ile Asp Phe Gly Phe Ala Arg Leu Arg Pro Gln
545 550 555 560
Ser Pro Gly Val Pro Met Gln Thr Pro Cys Phe Thr Leu Gln Tyr Ala
565 570 575
Ala Pro Glu Leu Leu Ala Gln Gln Gly Tyr Asp Glu Ser Cys Asp Leu
580 585 590
Trp Ser Leu Gly Val Ile Leu Tyr Met Met Leu Ser Gly Gln Val Pro
595 600 605
Phe Gln Gly Ala Ser Gly Gln Gly Gly Gln Ser Gln Ala Ala Glu Ile
610 615 620
Met Cys Lys Ile Arg Glu Gly Arg Phe Ser Leu Asp Gly Glu Ala Trp
625 630 635 640
Gln Gly Val Ser Glu Glu Ala Lys Glu Leu Val Arg Gly Leu Leu Thr
645 650 655
Val Asp Pro Ala Lys Arg Leu Lys Leu Glu Gly Leu Arg Gly Ser Ser
660 665 670
Trp Leu Gln Asp Gly Ser Ala Arg Ser Ser Pro Pro Leu Arg Thr Pro
675 680 685
Asp Val Leu Glu Ser Ser Gly Pro Ala Val Arg Ser Gly Leu Asn Ala
690 695 700
Thr Phe Met Ala Phe Asn Arg Gly Lys Arg Glu Gly Phe Phe Leu Lys
705 710 715 720
Ser ValGlu Asn Ala Pro Leu Ala Lys Arg Arg Lys Gln Lys Leu Arg
725 730 735
Ser Ala Thr Ala Ser Arg Arg Gly Ser Pro Ala Pro Ala Asn Pro Gly
740 745 750
Arg Ala Pro Val Ala Ser Lys Gly Ala Pro Arg Arg Ala Asn Gly Pro
755 760 765
Leu Pro Pro Ser
770
<210>147
<211>1684
<212>PRT
<213>人
<400>147
Met Glu Asp Leu Val Gln Asp Gly Val Ala Ser Pro Ala Thr Pro Gly
1 5 10 15
Thr Gly Lys Ser Lys Leu Glu Thr Leu Pro Lys Glu Asp Leu Ile Lys
20 25 30
Phe Ala Lys Lys Gln Met Met Leu Ile Gln Lys Ala Lys Ser Arg Cys
35 40 45
Thr Glu Leu Glu Lys Glu Ile Glu Glu Leu Arg Ser Lys Pro Val Thr
50 55 60
Glu Gly Thr Gly Asp Ile Ile Lys Ala Leu Thr Glu Arg Leu Asp Ala
70 75 80
Leu Leu Leu Glu Lys Ala Glu Thr Glu Gln Gln Cys Leu Ser Leu Lys
85 90 95
Lys Glu Asn Ile Lys Met Lys Gln Glu Val Glu Asp Ser Val Thr Lys
100 105 110
Met Gly Asp Ala His Lys Glu Leu Glu Gln Ser His Ile Asn Tyr Val
115 120 125
Lys Glu Ile Glu Asn Leu Lys Asn Glu Leu Met Ala Val Arg Ser Lys
130 135 140
Tyr Ser Glu Asp Lys Ala Asn Leu Gln Lys Gln Leu Glu Glu Ala Met
145 150 155 160
Asn Thr Gln Leu Glu Leu Ser Glu Gln Leu Lys Phe Gln Asn Asn Ser
165 170 175
Glu Asp Asn Val Lys Lys Leu Gln Glu Glu Ile Glu Lys Ile Arg Pro
180 185 190
Gly Phe Glu Glu Gln Ile Leu Tyr Leu Gln Lys Gln Leu Asp Ala Thr
195 200 205
Thr Asp Glu Lys Lys Glu Thr Val Thr Gln Leu Gln Asn Ile Ile Glu
210 215 220
Ala Asn Ser Gln His Tyr Gln Lys Asn Ile Asn Ser Leu Gln Glu Glu
225 230 235 240
Leu Leu Gln Leu Lys Ala Ile His Gln Glu Glu Val Lys Glu Leu Met
245 250 255
Cys Gln Ile Glu Ala Ser Ala Lys Glu His Glu Ala Glu Ile Asn Lys
260 265 270
Leu Asn Glu Leu Lys Glu Asn Leu ValLys Gln Cys Glu Ala Ser Glu
275 280 285
Lys Asn Ile Gln Lys Lys Tyr Glu Cys Glu Leu Glu Asn Leu Arg Lys
290 295 300
Ala Thr Ser Asn Ala Asn Gln Asp Asn Gln Ile Cys Ser Ile Leu Leu
305 310 315 320
Gln Glu Asn Thr Phe Val Glu Gln Val Val Asn Glu Lys Val Lys His
325 330 335
Leu Glu Asp Thr Leu Lys Glu Leu Glu Ser Gln His Ser Ile Leu Lys
340 345 350
Asp Glu Val Thr Tyr Met Asn Asn Leu Lys Leu Lys Leu Glu Met Asp
355 360 365
Ala Gln His Ile Lys Asp Glu Phe Phe His Glu Arg Glu Asp Leu Glu
370 375 380
Phe Lys Ile Asn Glu Leu Leu Leu Ala Lys Glu Glu Gln Gly Cys Val
385 390 395 400
Ile Glu Lys Leu Lys Ser Glu Leu Ala Gly Leu Asn Lys Gln Phe Cys
405 410 415
Tyr Thr Val Glu Gln His Asn Arg Glu Val Gln Ser Leu Lys Glu Gln
420 425 430
His Gln Lys Glu Ile Ser Glu Leu Asn Glu Thr Phe Leu Ser Asp Ser
435 440 445
Glu Lys Glu Lys Leu Thr Leu Met Phe Glu Ile Gln Gly Leu Lys Glu
450 455 460
Gln Cys Glu Asn Leu Gln Gln Glu Lys Gln Glu Ala Ile Leu Asn Tyr
465 470 475 480
Glu Ser Leu Arg Glu Ile Met Glu Ile Leu Gln Thr Glu Leu Gly Glu
485 490 495
Ser Ala Gly Lys Ile Ser Gln Glu Phe Glu Ser Met Lys Gln Gln Gln
500 505 510
Ala Ser Asp Val His Glu Leu Gln Gln Lys Leu Arg Thr Ala Phe Thr
515 520 525
Glu Lys Asp Ala Leu Leu Glu Thr Val Asn Arg Leu Gln Gly Glu Asn
530 535 540
Glu Lys Leu Leu Ser Gln Gln Glu Leu Val Pro Glu Leu Glu Asn Thr
545 550 555 560
Ile Lys Asn Leu Gln Glu Lys Asn Gly Val Tyr Leu Leu Ser Leu Ser
565 570 575
Gln Arg Asp Thr Met Leu Lys Glu Leu Glu Gly Lys Ile Asn Ser Leu
580 585 590
Thr Glu Glu Lys Asp Asp Phe Ile Asn Lys Leu Lys Asn Ser His Glu
595 600 605
Glu Met Asp Asn Phe His Lys Lys Cys Glu Arg Glu Glu Arg Leu Ile
610 615 620
Leu Glu Leu Gly Lys Lys Val Glu Gln Thr Ile Gln Tyr Asn Ser Glu
625 630 635 640
Leu Glu Gln Lys Val Asn Glu Leu Thr Gly Gly Leu Glu Glu Thr Leu
645 650 655
Lys Glu Lys Asp Gln Asn Asp Gln Lys Leu Glu Lys Leu Met Val Gln
660 665 670
Met Lys Val Leu Ser Glu Asp Lys Glu Val Leu Ser Ala Glu Val Lys
675 680 685
Ser Leu Tyr Glu Glu Asn Asn Lys Leu Ser Ser Glu Lys Lys Gln Leu
690 695 700
Ser Arg Asp Leu Glu Val Phe Leu Ser Gln Lys Glu Asp Val Ile Leu
705 710 715 720
Lys Glu His Ile Thr Gln Leu Glu Lys Lys Leu Gln Leu Met Val Glu
725 730 735
Glu Gln Asp Asn Leu Asn Lys Leu Leu Glu Asn Glu Gln Val Gln Lys
740 745 750
Leu Phe Val Lys Thr Gln Leu Tyr Gly Phe Leu Lys Glu Met Gly Ser
755 760 765
Glu Val Ser Glu Asp Ser Glu Glu Lys Asp Val Val Asn Val Leu Gln
770 775 780
Ala Val Gly Glu Ser Leu Ala Lys Ile Asn Glu Glu Lys Cys Asn Leu
785 790 795 800
Ala Phe Gln Arg Asp Glu Lys Val Leu Glu Leu Glu Lys Glu Ile Lys
805 810 815
Cys Leu Gln Glu Glu Ser Val Val Gln Cys Glu Glu Leu Lys Ser Leu
820 825 830
Leu Arg Asp Tyr Glu Gln Glu Lys Val Leu Leu Arg Lys Glu Leu Glu
835 840 845
Glu Ile Gln Ser Glu Lys Glu Ala Leu Gln Ser Asp Leu Leu Glu Met
850 855 860
Lys Asn Ala Asn Glu Lys Thr Arg Leu Glu Asn Gln Asn Leu Leu Ile
865 870 875 880
Gln Val Glu Glu Val Ser Gln Thr Cys Ser Lys Ser Glu Ile His Asn
885 890 895
Glu Lys Glu Lys Cys Phe lle Lys Glu His Glu Asn Leu Lys Pro Leu
900 905 910
Leu Glu Gln Lys Glu Leu Arg Asp Arg Arg Ala Glu Leu Ile Leu Leu
915 920 925
Lys Asp Ser Leu Ala Lys Ser Pro Ser Val Lys Asn Asp Pro Leu Ser
930 935 940
Ser Val Lys Glu Leu Glu Glu Lys Ile Glu Asn Leu Glu Lys Glu Cys
945 950 955 960
Lys Glu Lys Glu Glu Lys Ile Asn Lys Ile Lys Leu Val Ala Val Lys
965 970 975
Ala Lys Lys Glu Leu Asp Ser Ser Arg Lys Glu Thr Gln Thr Val Lys
980 985 990
Glu Glu Leu Glu Ser Leu Arg Ser Glu Lys Asp Gln Leu Ser Ala Ser
995 1000 1005
Met Arg Asp Leu Ile Gln Gly Ala Glu Ser Tyr Lys Asn Leu Leu
1010 1015 1020
Leu Glu Tyr Glu Lys Gln Ser Glu Gln Leu Asp Val Glu Lys Glu
1025 1030 1035
Arg Ala Asn Asn Phe Glu His Arg Ile Glu Asp Leu Thr Arg Gln
1040 1045 1050
Leu Arg Asn Ser Thr Leu Gln Cys Glu Thr Ile Asn Ser Asp Asn
1055 1060 1065
Glu Asp Leu Leu Ala Arg Ile Glu Thr Leu Gln Ser Asn Ala Lys
1070 1075 1080
Leu Leu Glu Val Gln Ile Leu Glu Val Gln Arg Ala Lys Ala Met
1085 1090 1095
Val Asp Lys Glu Leu Glu Ala Glu Lys Leu Gln Lys Glu Gln Lys
1100 1105 1110
Ile Lys Glu His Ala Thr Thr Val Asn Glu Leu Glu Glu Leu Gln
1115 1120 1125
Val Gln Leu Gln Lys Glu Lys Lys Gln Leu Gln Lys Thr Met Gln
1130 1135 1140
Glu Leu Glu Leu Val Lys Lys Asp Ala Gln Gln Thr Thr Leu Met
1145 1150 1155
Asn Met Glu Ile Ala Asp Tyr Glu Arg Leu Met Lys Glu Leu Asn
1160 1165 1170
Gln Lys Leu Thr Asn Lys Asn Asn Lys Ile Glu Asp Leu Glu Gln
1175 1180 1185
Glu Ile Lys Ile Gln Lys Gln Lys Gln Glu Thr Leu Gln Glu Glu
1190 1195 1200
Ile Thr Ser Leu Gln Ser Ser Val Gln Gln Tyr Glu Glu Lys Asn
1205 1210 1215
Thr Lys Ile Lys Gln Leu Leu Val Lys Thr Lys Lys Glu Leu Ala
1220 1225 1230
Asp Ser Lys Gln Ala Glu Thr Asp His Leu Ile Leu Gln Ala Ser
1235 1240 1245
Leu Lys Gly Glu Leu Glu Ala Ser Gln Gln Gln Val Glu Val Tyr
1250 1255 1260
Lys Ile Gln Leu Ala Glu Ile Thr Ser Glu Lys His Lys Ile His
1265 1270 1275
Glu His Leu Lys Thr Ser Ala Glu Gln His Gln Arg Thr Leu Ser
1280 1285 1290
Ala Tyr Gln Gln Arg Val Thr Ala Leu Gln Glu Glu Cys Arg Ala
1295 1300 1305
Ala Lys Ala Glu Gln Ala Thr Val Thr Ser Glu Phe Glu Ser Tyr
1310 1315 1320
Lys Val Arg Val His Asn Val Leu Lys Gln Gln Lys Asn Lys Ser
1325 1330 1335
Met Ser Gln Ala Glu Thr Glu Gly Ala Lys Gln Glu Arg Glu His
1340 1345 1350
Leu Glu Met Leu Ile Asp Gln Leu Lys Ile Lys Leu Gln Asp Ser
1355 1360 1365
Gln Asn Asn Leu Gln Ile Asn Val Ser Glu Leu Gln Thr Leu Gln
1370 1375 1380
Ser Glu His Asp Thr Leu Leu Glu Arg His Asn Lys Met Leu Gln
1385 1390 1395
Glu Thr Val Ser Lys Glu Ala Glu Leu Arg Glu Lys Leu Cys Ser
1400 1405 1410
Ile Gln Ser Glu Asn Met Met Met Lys Ser Glu His Thr Gln Thr
1415 1420 1425
Val Ser Gln Leu Thr Ser Gln Asn Glu Val Leu Arg Asn Ser Phe
1430 1435 1440
Arg Asp Gln Val Arg His Leu Gln Glu Glu His Arg Lys Thr Val
1445 1450 1455
Glu Thr Leu Gln Gln Gln Leu Ser Lys Met Glu Ala Gln Leu Phe
1460 1465 1470
Gln Leu Lys Asn Glu Pro Thr Thr Arg Ser Pro Val Ser Ser Gln
1475 1480 1485
Gln Ser Leu Lys Asn Leu Arg Glu Arg Arg Asn Thr Asp Leu Pro
1490 1495 1500
Leu Leu Asp Met His Thr Val Thr Arg Glu Glu Gly Glu Gly Met
1505 1510 1515
Glu Thr Thr Asp Thr Glu Ser Val Ser Ser Ala Ser Thr Tyr Thr
1520 1525 1530
Gln Ser Leu Glu Gln Leu Leu Asn Ser Pro Glu Thr Lys Leu Glu
1535 1540 1545
Pro Pro Leu Trp His Ala Glu Phe Thr Lys Glu Glu Leu Val Gln
1550 1555 1560
Lys Leu Ser Ser Thr Thr Lys Ser Ala Asp His Leu Asn Gly Leu
1565 1570 1575
Leu Arg Glu Thr Glu Ala Thr Asn Ala Ile Leu Met Glu Gln Ile
1580 1585 1590
Lys Leu Leu Lys Ser Glu Ile Arg Arg Leu Glu Arg Asn Gln Glu
1595 1600 1605
Arg Glu Lys Ser Ala Ala Asn Leu Glu Tyr Leu Lys Asn Val Leu
1610 1615 1620
Leu Gln Phe Ile Phe Leu Lys Pro Gly Ser Glu Arg Glu Arg Leu
1625 1630 1635
Leu Pro Val Ile Asn Thr Met Leu Gln Leu Ser Pro Glu Glu Lys
1640 1645 1650
Gly Lys Leu Ala Ala Val Ala Gln Gly Glu Glu Glu Asn Ala Ser
1655 1660 1665
Arg Ser Ser Gly Trp Ala Ser Tyr Leu His Ser Trp Ser Gly Leu
1670 1675 1680
Arg
<210>148
<211>288
<212>PRT
<213>人
<400>148
Met Val Gly Val Gly Gly Gly Asp Val Glu Asp Val Thr Pro Arg Pro
1 5 10 15
Gly Gly Cys Gln Ile Ser Gly Arg Ala Ala Arg Gly Cys Asn Gly Ile
20 25 30
Pro Gly Ala Ala Ala Trp Glu Ala Ala Leu Pro Arg Arg Arg Pro Arg
35 40 45
Arg His Pro Ser Val Asn Pro Arg Ser Arg Ala Ala Gly Ser Pro Arg
50 55 60
Thr Arg Gly Arg Arg Thr Glu Glu Arg Pro Ser Gly Ser Arg Leu Gly
65 70 75 80
Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly Gly Arg
85 90 95
Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg Gly Arg
100 105 110
Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser Arg Pro
115 120 125
Gly Pro Ala Gly Thr Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala
130 135 140
Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys
145 150 155 160
Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile
165 170 175
His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His
180 185 190
Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys
195 200 205
Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu
210 215 220
Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu
225 230 235 240
Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp
245 250 255
Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr
260 265 270
Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser
275 280 285
<210>149
<211>582
<212>PRT
<213>人
<400>149
Met Ser Pro Ala Pro Arg Pro Pro Arg Cys Leu Leu Leu Pro Leu Leu
1 5 10 15
Thr Leu Gly Thr Ala Leu Ala Ser Leu Gly Ser Ala Gln Ser Ser Ser
20 25 30
Phe Ser Pro Glu Ala Trp Leu Gln Gln Tyr Gly Tyr Leu Pro Pro Gly
35 40 45
Asp Leu Arg Thr His Thr Gln Arg Ser Pro Gln Ser Leu Ser Ala Ala
50 55 60
Ile Ala Ala Met Gln Lys Phe Tyr Gly Leu Gln Val Thr Gly Lys Ala
65 70 75 80
Asp Ala Asp Thr Met Lys Ala Met Arg Arg Pro Arg Cys Gly Val Pro
85 90 95
Asp Lys Phe Gly Ala Glu Ile Lys Ala Asn Val Arg Arg Lys Arg Tyr
100 105 110
Ala Ile Gln Gly Leu Lys Trp Gln His Asn Glu Ile Thr Phe Cys Ile
115 120 125
Gln Asn Tyr Thr Pro Lys Val Gly Glu Tyr Ala Thr Tyr Glu Ala Ile
130 135 140
Arg Lys Ala Phe Arg Val Trp Glu Ser Ala Thr Pro Leu Arg Phe Arg
145 150 155 160
Glu Val Pro Tyr Ala Tyr Ile Arg Glu Gly His Glu Lys Gln Ala Asp
165 170 175
lle Met Ile Phe Phe Ala Glu Gly Phe His Gly Asp Ser Thr Pro Phe
180 185 190
Asp Gly Glu Gly Gly Phe Leu Ala His Ala Tyr Phe Pro Gly Pro Asn
195 200 205
Ile Gly Gly Asp Thr His Phe Asp Ser Ala Glu Pro Trp Thr Val Arg
210 215 220
Asn Glu Asp Leu Asn Gly Asn Asp Ile Phe Leu Val Ala Val His Glu
225 230 235 240
Leu Gly His Ala Leu Gly Leu Glu His Ser Ser Asp Pro Ser Ala Ile
245 250 255
Met Ala Pro Phe Tyr Gln Trp Met Asp Thr Glu Asn Phe Val Leu Pro
260 265 270
Asp Asp Asp Arg Arg Gly Ile Gln Gln Leu Tyr Gly Gly Glu Ser Gly
275 280 285
Phe Pro Thr Lys Met Pro Pro Gln Pro Arg Thr Thr Ser Arg Pro Ser
290 295 300
Val Pro Asp Lys Pro Lys Asn Pro Thr Tyr Gly Pro Asn Ile Cys Asp
305 310 315 320
Gly Asn Phe Asp Thr Val Ala Met Leu Arg Gly Glu Met Phe Val Phe
325 330 335
Lys Glu Arg Trp Phe Trp Arg Val Arg Asn Asn Gln Val Met Asp Gly
340 345 350
Tyr Pro Met Pro Ile Gly Gln Phe Trp Arg Gly Leu Pro Ala Ser Ile
355 360 365
Asn Thr Ala Tyr Glu Arg Lys Asp Gly Lys Phe Val Phe Phe Lys Gly
370 375 380
Asp Lys His Trp Val Phe Asp Glu Ala Ser Leu Glu Pro Gly Tyr Pro
385 390 395 400
Lys His Ile Lys Glu Leu Gly Arg Gly Leu Pro Thr Asp Lys Ile Asp
405 410 415
Ala Ala Leu Phe Trp Met Pro Asn Gly Lys Thr Tyr Phe Phe Arg Gly
420 425 430
Asn Lys Tyr Tyr Arg Phe Asn Glu Glu Leu Arg Ala Val Asp Ser Glu
435 440 445
Tyr Pro Lys Asn Ile Lys Val Trp Glu Gly Ile Pro Glu Ser Pro Arg
450 455 460
Gly Ser Phe Met Gly Ser Asp Glu Val Phe Thr Tyr Phe Tyr Lys Gly
465 470 475 480
Asn Lys Tyr Trp Lys Phe Asn Asn Gln Lys Leu Lys Val Glu Pro Gly
485 490 495
Tyr Pro Lys Ser Ala Leu Arg Asp Trp Met Gly Cys Pro Ser Gly Gly
500 505 510
Arg Pro Asp Glu Gly Thr Glu Glu Glu Thr Glu Val Ile Ile Ile Glu
515 520 525
Val Asp Glu Glu Gly Gly Gly Ala Val Ser Ala Ala Ala Val Val Leu
530 535 540
Pro Val Leu Leu Leu Leu Leu Val Leu Ala Val Gly Leu Ala Val Phe
545 550 555 560
Phe Phe Arg Arg His Gly Thr Pro Arg Arg Leu Leu Tyr Cys Gln Arg
565 570 575
Ser Leu Leu Asp Lys Val
580
<210>150
<211>1255
<212>PRT
<213>人
<400>150
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
1 5 10 15
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
20 25 30
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
35 40 45
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
50 55 60
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65 70 75 80
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
85 90 95
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
100 105 110
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
115 120 125
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
130 135 140
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145 150 155 160
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
165 170 175
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
180 185 190
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
195 200 205
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
210 215 220
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225 230 235 240
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
245 250 255
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
260 265 270
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
275 280 285
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
290 295 300
Ser Thr Asp ValGly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305 310 315 320
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
325 330 335
Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu
340 345 350
Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys
355 360 365
Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp
370 375 380
Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe
385 390 395 400
Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro
405 410 415
Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg
420 425 430
Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu
435 440 445
Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly
450 455 460
Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val
465 470 475 480
Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr
485 490 495
Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His
500 505 510
Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys
515 520 525
Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys
530 535 540
Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys
545 550 555 560
Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys
565 570 575
Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp
580 585 590
Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu
595 600 605
Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln
610 615 620
Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys
625 630 635 640
Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser
645 650 655
Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly
660 665 670
Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg
675 680 685
Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly
690 695 700
Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu
705 710 715 720
Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys
725 730 735
Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile
740 745 750
Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu
755 760 765
Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg
770 775 780
Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu
785 790 795 800
Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg
805 810 815
Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly
820 825 830
Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala
835 840 845
Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe
850 855 860
Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp
865 870 875 880
Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg
885 890 895
Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val
900 905 910
Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala
915 920 925
Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro
930 935 940
Pro Ile Cys Thr Ile Asp Val Tyr Met lle Met Val Lys Cys Trp Met
945 950 955 960
Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe
965 970 975
Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu
980 985 990
Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser Leu
995 1000 1005
Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu Tyr
1010 1015 1020
Leu Val Pro Gln Gln Gly Phe Phe Cys Pro Asp Pro Ala Pro Gly
1025 1030 1035
Ala Gly Gly Met Val His His Arg His Arg Ser Ser Ser Thr Arg
1040 1045 1050
Ser Gly Gly Gly Asp Leu Thr Leu Gly Leu Glu Pro Ser Glu Glu
1055 1060 1065
Glu Ala Pro Arg Ser Pro Leu Ala Pro Ser Glu Gly Ala Gly Ser
1070 1075 1080
Asp Val Phe Asp Gly Asp Leu Gly Met Gly Ala Ala Lys Gly Leu
1085 1090 1095
Gln Ser Leu Pro Thr His Asp Pro Ser Pro Leu Gln Arg Tyr Ser
1100 1105 1110
Glu Asp Pro Thr Val Pro Leu Pro Ser Glu Thr Asp Gly Tyr Val
1115 1120 1125
Ala Pro Leu Thr Cys Ser Pro Gln Pro Glu Tyr Val Asn Gln Pro
1130 1135 1140
Asp Val Arg Pro Gln Pro Pro Ser Pro Arg Glu Gly Pro Leu Pro
1145 1150 1155
Ala Ala Arg Pro Ala Gly Ala Thr Leu Glu Arg Pro Lys Thr Leu
1160 1165 1170
Ser Pro Gly Lys Asn Gly Val Val Lys Asp Val Phe Ala Phe Gly
1175 1180 1185
Gly Ala Val Glu Asn Pro Glu Tyr Leu Thr Pro Gln Gly Gly Ala
1190 1195 1200
Ala Pro Gln Pro His Pro Pro Pro Ala Phe Ser Pro Ala Phe Asp
1205 1210 1215
Asn Leu Tyr Tyr Trp Asp Gln Asp Pro Pro Glu Arg Gly Ala Pro
1220 1225 1230
Pro Ser Thr Phe Lys Gly Thr Pro Thr Ala Glu Asn Pro Glu Tyr
1235 1240 1245
Leu Gly Leu Asp Val Pro Val
1250 1255
<210>151
<211>552
<212>PRT
<213>人
<400>15l
Met Ala Glu Lys Gln Lys His Asp Gly Arg Val Lys Ile Gly His Tyr
1 5 10 15
Val Leu Gly Asp Thr Leu Gly Val Gly Thr Phe Gly Lys Val Lys Ile
20 25 30
Gly Glu His Gln Leu Thr Gly His Lys Val Ala Val Lys Ile Leu Asn
35 40 45
Arg Gln Lys Ile Arg Ser Leu Asp Val Val Gly Lys Ile Lys Arg Glu
50 55 60
Ile Gln Asn Leu Lys Leu Phe Arg His Pro His Ile Ile Lys Leu Tyr
65 70 75 80
Gln Val Ile Ser Thr Pro Thr Asp Phe Phe Met Val Met Glu Tyr Val
85 90 95
Ser Gly Gly Glu Leu Phe Asp Tyr Ile Cys Lys His Gly Arg Val Glu
100 105 110
Glu Met Glu Ala Arg Arg Leu Phe Gln Gln Ile Leu Ser Ala Val Asp
115 120 125
Tyr Cys His Arg His Met Val Val His Arg Asp Leu Lys Pro Glu Asn
130 135 140
Val Leu Leu Asp Ala His Met Asn Ala Lys Ile Ala Asp Phe Gly Leu
145 150 155 160
Ser Asn Met Met Ser Asp Gly Glu Phe Leu Arg Thr Ser Cys Gly Ser
165 170 175
Pro Asn Tyr Ala Ala Pro Glu Val Ile Ser Gly Arg Leu Tyr Ala Gly
180 185 190
Pro Glu Val Asp Ile Trp Ser Cys Gly Val Ile Leu Tyr Ala Leu Leu
195 200 205
Cys Gly Thr Leu Pro Phe Asp Asp Glu His Val Pro Thr Leu Phe Lys
210 215 220
Lys Ile Arg Gly Gly Val Phe Tyr Ile Pro Glu Tyr Leu Asn Arg Ser
225 230 235 240
Val Ala Thr Leu Leu Met His Met Leu Gln Val Asp Pro Leu Lys Arg
245 250 255
Ala Thr Ile Lys Asp Ile Arg Glu His Glu Trp Phe Lys Gln Asp Leu
260 265 270
Pro Ser Tyr Leu Phe Pro Glu Asp Pro Ser Tyr Asp Ala Asn Val Ile
275 280 285
Asp Asp Glu Ala Val Lys Glu Val Cys Glu Lys Phe Glu Cys Thr Glu
290 295 300
Ser Glu Val Met Asn Ser Leu Tyr Ser Gly Asp Pro Gln Asp Gln Leu
305 310 315 320
Ala Val Ala Tyr His Leu Ile Ile Asp Asn Arg Arg Ile Met Asn Gln
325 330 335
Ala Ser Glu Phe Tyr Leu Ala Ser Ser Pro Pro Ser Gly Ser Phe Met
340 345 350
Asp Asp Ser Ala Met His Ile Pro Pro Gly Leu Lys Pro His Pro Glu
355 360 365
Arg Met Pro Pro Leu Ile Ala Asp Ser Pro Lys Ala Arg Cys Pro Leu
370 375 380
Asp Ala Leu Asn Thr Thr Lys Pro Lys Ser Leu Ala Val Lys Lys Ala
385 390 395 400
Lys Trp His Leu Gly Ile Arg Ser Gln Ser Lys Pro Tyr Asp Ile Met
405 410 415
Ala Glu Val Tyr Arg Ala Met Lys Gln Leu Asp Phe Glu Trp Lys Val
420 425 430
Val Asn Ala Tyr His Leu Arg Val Arg Arg Lys Asn Pro Val Thr Gly
435 440 445
Asn Tyr Val Lys Met Ser Leu Gln Leu Tyr Leu Val Asp Asn Arg Ser
450 455 460
Tyr Leu Leu Asp Phe Lys Ser Ile Asp Asp Glu Val Val Glu Gln Arg
465 470 475 480
Ser Gly Ser Ser Thr Pro Gln Arg Ser Cys Ser Ala Ala Gly Leu His
485 490 495
Arg Pro Arg Ser Ser Phe Asp Ser Thr Thr Ala Glu Ser His Ser Leu
500 505 510
Ser Gly Ser Leu Thr Gly Ser Leu Thr Gly Ser Thr Leu Ser Ser Val
515 520 525
Ser Pro Arg Leu Gly Ser His Thr Met Asp Phe Phe Glu Met Cys Ala
530 535 540
Ser Leu Ile Thr Thr Leu Ala Arg
545 550
<210>152
<211>837
<212>PRT
<213>人
<400>152
Met Phe Leu Trp Leu Phe Leu Ile Leu Ser Ala Leu Ile Ser Ser Thr
1 5 10 15
Asn Ala Asp Ser Asp Ile Ser Val Glu Ile Cys Asn Val Cys Ser Cys
20 25 30
Val Ser Val Glu Asn Val Leu Tyr Val Asn Cys Glu Lys Val Ser Val
35 40 45
Tyr Arg Pro Asn Gln Leu Lys Pro Pro Trp Ser Asn Phe Tyr His Leu
50 55 60
Asn Phe Gln Asn Asn Phe Leu Asn Ile Leu Tyr Pro Asn Thr Phe Leu
65 70 75 80
Asn Phe Ser His Ala Val Ser Leu His Leu Gly Asn Asn Lys Leu Gln
85 90 95
Asn Ile Glu Gly Gly Ala Phe Leu Gly Leu Ser Ala Leu Lys Gln Leu
100 105 110
His Leu Asn Asn Asn Glu Leu Lys Ile Leu Arg Ala Asp Thr Phe Leu
115 120 125
Gly Ile Glu Asn Leu Glu Tyr Leu Gln Ala Asp Tyr Asn Leu Ile Lys
130 135 140
Tyr Ile Glu Arg Gly Ala Phe Asn Lys Leu His Lys Leu Lys Val Leu
145 150 155 160
Ile Leu Asn Asp Asn Leu Ile Ser Phe Leu Pro Asp Asn Ile Phe Arg
165 170 175
Phe Ala Ser Leu Thr His Leu Asp Ile Arg Gly Asn Arg Ile Gln Lys
180 185 190
Leu Pro Tyr Ile Gly Val Leu Glu His Ile Gly Arg Val Val Glu Leu
195 200 205
Gln Leu Glu Asp Asn Pro Trp Asn Cys Ser Cys Asp Leu Leu Pro Leu
210 215 220
Lys Ala Trp Leu Glu Asn Met Pro Tyr Asn Ile Tyr Ile Gly Glu Ala
225 230 235 240
Ile Cys Glu Thr Pro Ser Asp Leu Tyr Gly Arg Leu Leu Lys Glu Thr
245 250 255
Asn Lys Gln Glu Leu Cys Pro Met Gly Thr Gly Ser Asp Phe Asp Val
260 265 270
Arg Ile Leu Pro Pro Ser Gln Leu Glu Asn Gly Tyr Thr Thr Pro Asn
275 280 285
Gly His Thr Thr Gln Thr Ser Leu His Arg Leu Val Thr Lys Pro Pro
290 295 300
Lys Thr Thr Asn Pro Ser Lys Ile Ser Gly Ile Val Ala Gly Lys Ala
305 310 315 320
Leu Ser Asn Arg Asn Leu Ser Gln Ile Val Ser Tyr Gln Thr Arg Val
325 330 335
Pro Pro Leu Thr Pro Cys Pro Ala Pro Cys Phe Cys Lys Thr His Pro
340 345 350
Ser Asp Leu Gly Leu Ser Val Asn Cys Gln Glu Lys Asn Ile Gln Ser
355 360 365
Met Ser Glu Leu Ile Pro Lys Pro Leu Asn Ala Lys Lys Leu His Val
370 375 380
Asn Gly Asn Ser Ile Lys Asp Val Asp Val Ser Asp Phe Thr Asp Phe
385 390 395 400
Glu Gly Leu Asp Leu Leu His Leu Gly Ser Asn Gln Ile Thr Val Ile
405 410 415
Lys Gly Asp Val Phe His Asn Leu Thr Asn Leu Arg Arg Leu Tyr Leu
420 425 430
Asn Gly Asn Gln Ile Glu Arg Leu Tyr Pro Glu Ile Phe Ser Gly Leu
435 440 445
His Asn Leu Gln Tyr Leu Tyr Leu Glu Tyr Asn Leu Ile Lys Glu Ile
450 455 460
Ser Ala Gly Thr Phe Asp Ser Met Pro Asn Leu Gln Leu Leu Tyr Leu
465 470 475 480
Asn Asn Asn Leu Leu Lys Ser Leu Pro Val Tyr Ile Phe Ser Gly Ala
485 490 495
Pro Leu Ala Arg Leu Asn Leu Arg Asn Asn Lys Phe Met Tyr Leu Pro
500 505 510
Val Ser Gly Val Leu Asp Gln Leu Gln Ser Leu Thr Gln Ile Asp Leu
515 520 525
Glu Gly Asn Pro Trp Asp Cys Thr Cys Asp Leu Val Ala Leu Lys Leu
530 535 540
Trp Val Glu Lys Leu Ser Asp Gly Ile Val Val Lys Glu Leu Lys Cys
545 550 555 560
Glu Thr Pro Val Gln Phe Ala Asn Ile Glu Leu Lys Ser Leu Lys Asn
565 570 575
Glu Ile Leu Cys Pro Lys Leu Leu Asn Lys Pro Ser Ala Pro Phe Thr
580 585 590
Ser Pro Ala Pro Ala Ile Thr Phe Thr Thr Pro Leu Gly Pro Ile Arg
595 600 605
Ser Pro Pro Gly Gly Pro Val Pro Leu Ser Ile Leu Ile Leu Ser Ile
610 615 620
Leu Val Val Leu Ile Leu Thr Val Phe Val Ala Phe Cys Leu Leu Val
625 630 635 640
Phe Val Leu Arg Arg Asn Lys Lys Pro Thr Val Lys His Glu Gly Leu
645 650 655
Gly Asn Pro Asp Cys Gly Ser Met Gln Leu Gln Leu Arg Lys His Asp
660 665 670
His Lys Thr Asn Lys Lys Asp Gly Leu Ser Thr Glu Ala Phe Ile Pro
675 680 685
Gln Thr Ile Glu Gln Met Ser Lys Ser His Thr Cys Gly Leu Lys Glu
690 695 700
Ser Glu Thr Gly Phe Met Phe Ser Asp Pro Pro Gly Gln Lys Val Val
705 710 715 720
Met Arg Asn Val Ala Asp Lys Glu Lys Asp Leu Leu His Val Asp Thr
725 730 735
Arg Lys Arg Leu Ser Thr Ile Asp Glu Leu Asp Glu Leu Phe Pro Ser
740 745 750
Arg Asp Ser Asn Val Phe Ile Gln Asn Phe Leu Glu Ser Lys Lys Glu
755 760 765
Tyr Asn Ser Ile Gly Val Ser Gly Phe Glu Ile Arg Tyr Pro Glu Lys
770 775 780
Gln Pro Asp Lys Lys Ser Lys Lys Ser Leu Ile Gly Gly Asn His Ser
785 790 795 800
Lys Ile Val Val Glu Gln Arg Lys Ser Glu Tyr Phe Glu Leu Lys Ala
805 810 815
Lys Leu Gln Ser Ser Pro Asp Tyr Leu Gln Val Leu Glu Glu Gln Thr
820 825 830
Ala Leu Asn Lys Ile
835
<210>153
<211>379
<212>PRT
<213>人
<400>153
Met Pro Arg Ser Ser Arg Ser Pro Gly Asp Pro Gly Ala Leu Leu Glu
1 5 10 15
Asp Val Ala His Asn Pro Arg Pro Arg Arg Ile Ala Gln Arg Gly Arg
20 25 30
Asn Thr Ser Arg Met Ala Glu Asp Thr Ser Pro Asn Met Asn Asp Asn
35 40 45
Ile Leu Leu Pro Val Arg Asn Asn Asp Gln Ala Leu Gly Leu Thr Gln
50 55 60
Cys Met Leu Gly Cys Val Ser Trp Phe Thr Cys Phe Ala Cys Ser Leu
65 70 75 80
Arg Thr Gln Ala Gln Gln Val Leu Phe Asn Thr Cys Arg Cys Lys Leu
85 90 95
Leu Cys Gln Lys Leu Met Glu Lys Thr Gly Ile Leu Leu Leu Cys Ala
100 105 110
Phe Gly Phe Trp Met Phe Ser Ile His Leu Pro Ser Lys Met Lys Val
115 120 125
Trp Gln Asp Asp Ser Ile Asn Gly Pro Leu Gln Ser Leu Arg Leu Tyr
130 135 140
Gln Glu Lys Val Arg His His Ser Gly Glu Ile Gln Asp Leu Arg Gly
145 150 155 160
Ser Met Asn Gln Leu Ile Ala Lys Leu Gln Glu Met Glu Ala Met Ser
165 170 175
Asp Glu Gln Lys Met Ala Gln Lys Ile Met Lys Met Ile His Gly Asp
180 185 190
Tyr Ile Glu Lys Pro Asp Phe Ala Leu Lys Ser Ile Gly Ala Ser Ile
195 200 205
Asp Phe Glu His Thr Ser Val Thr Tyr Asn His Glu Lys Ala His Ser
210 215 220
Tyr Trp Asn Trp Ile Gln Leu Trp Asn Tyr Ala Gln Pro Pro Asp Val
225 230 235 240
Ile Leu Glu Pro Asn Val Thr Pro Gly Asn Cys Trp Ala Phe Glu Gly
245 250 255
Asp Arg Gly Gln Val Thr Ile Gln Leu Ala Gln Lys Val Tyr Leu Ser
260 265 270
Asn Leu Thr Leu Gln His Ile Pro Lys Thr Ile Ser Leu Ser Gly Ser
275 280 285
Leu Asp Thr Ala Pro Lys Asp Phe Val Ile Tyr Gly Met Glu Gly Ser
290 295 300
Pro Lys Glu Glu Val Phe Leu Gly Ala Phe Gln Phe Gln Pro Glu Asn
305 310 315 320
Ile Ile Gln Met Phe Pro Leu Gln Asn Gln Pro Ala Arg Ala Phe Ser
325 330 335
Ala Val Lys Val Lys Ile Ser Ser Asn Trp Gly Asn Pro Gly Phe Thr
340 345 350
Cys Leu Tyr Arg Val Arg Val His Gly Ser Val Ala Pro Pro Arg Glu
355 360 365
Gln Pro His Gln Asn Pro Tyr Pro Lys Arg Asp
370 375
<210>154
<211>601
<212>PRT
<213>人
<400>154
Met His Pro Leu Gln Cys Val Leu Gln Val Gln Arg Ser Leu Gly Trp
1 5 10 15
Gly Pro Leu Ala Ser Val Ser Trp Leu Ser Leu Arg Met Cys Arg Ala
20 25 30
His Ser Ser Leu Ser Ser Thr Met Cys Pro Ser Pro Glu Arg Gln Glu
35 40 45
Asp Gly Ala Arg Lys Asp Phe Ser Ser Arg Leu Ala Ala Gly Pro Thr
50 55 60
Phe Gln His Phe Leu Lys Ser Ala Ser Ala Pro Gln Glu Lys Leu Ser
65 70 75 80
Ser Glu Val Glu Asp Pro Pro Pro Tyr Leu Met Met Asp Glu Leu Leu
85 90 95
Gly Arg Gln Arg Lys Val Tyr Leu Glu Thr Tyr Gly Cys Gln Met Asn
100 105 110
Val Asn Asp Thr Glu Ile Ala Trp Ser Ile Leu Gln Lys Ser Gly Tyr
115 120 125
Leu Arg Thr Ser Asn Leu Gln Glu Ala Asp Val Ile Leu Leu Val Thr
130 135 140
Cys Ser Ile Arg Glu Lys Ala Glu Gln Thr Ile Trp Asn Arg Leu His
145 150 155 160
Gln Leu Lys Ala Leu Lys Thr Arg Arg Pro Arg Ser Arg Val Pro Leu
165 170 175
Arg Ile Gly Ile Leu Gly Cys Met Ala Glu Arg Leu Lys Glu Glu Ile
180 185 190
Leu Asn Arg Glu Lys Met Val Asp Ile Leu Ala Gly Pro Asp Ala Tyr
195 200 205
Arg Asp Leu Pro Arg Leu Leu Ala Val Ala Glu Ser Gly Gln Gln Ala
210 215 220
Ala Asn Val Leu Leu Ser Leu Asp Glu Thr Tyr Ala Asp Val Met Pro
225 230 235 240
Val Gln Thr Ser Ala Ser Ala Thr Ser Ala Phe Val Ser Ile Met Arg
245 250 255
Gly Cys Asp Asn Met Cys Ser Tyr Cys Ile Val Pro Phe Thr Arg Gly
260 265 270
Arg Glu Arg Ser Arg Pro Ile Ala Ser Ile Leu Glu Glu Val Lys Lys
275 280 285
Leu Ser Glu Gln Val Phe Leu Pro Pro Arg Pro Pro Lys Val Leu Gly
290 295 300
Leu Gln Gly Leu Lys Glu Val Thr Leu Leu Gly Gln Asn Val Asn Ser
305 310 315 320
Phe Arg Asp Asn Ser Glu Val Gln Phe Asn Ser Ala Val Pro Thr Asn
325 330 335
Leu Ser Arg Gly Phe Thr Thr Asn Tyr Lys Thr Lys Gln Gly Gly Leu
340 345 350
Arg Phe Ala His Leu Leu Asp Gln Val Ser Arg Val Asp Pro Glu Met
355 360 365
Arg Ile Arg Phe Thr Ser Pro His Pro Lys Asp Phe Pro Asp Glu Val
370 375 380
Leu Gln Leu Ile His Glu Arg Asp Asn Ile Cys Lys Gln Ile His Leu
385 390 395 400
Pro Ala Gln Ser Gly Ser Ser Arg Val Leu Glu Ala Met Arg Arg Gly
405 410 415
Tyr Ser Arg Glu Ala Tyr Val Glu Leu Val His His Ile Arg Glu Ser
420 425 430
Ile Pro Gly Val Ser Leu Ser Ser Asp Phe Ile Ala Gly Phe Cys Gly
435 440 445
Glu Thr Glu Glu Asp His Val Gln Thr Val Ser Leu Leu Arg Glu Val
450 455 460
Gln Tyr Asn Met Gly Phe Leu Phe Ala Tyr Ser Met Arg Gln Lys Thr
465 470 475 480
Arg Ala Tyr His Arg Leu Lys Asp Asp Val Pro Glu Glu Val Lys Leu
485 490 495
Arg Arg Leu Glu Glu Leu Ile Thr Ile Phe Arg Glu Glu Ala Thr Lys
500 505 510
Ala Asn Gln Thr Ser Val Gly Cys Thr Gln Leu Val Leu Val Glu Gly
515 520 525
Leu Ser Lys Arg Ser Ala Thr Asp Leu Cys Gly Arg Asn Asp Gly Asn
530 535 540
Leu Lys Val Ile Phe Pro Asp Ala Glu Met Glu Asp Val Asn Asn Pro
545 550 555 560
Gly Leu Arg Val Arg Ala Gln Pro Gly Asp Tyr Val Leu Val Lys Ile
565 570 575
Thr Ser Ala Ser Ser Gln Thr Leu Arg Gly His Val Leu Cys Arg Thr
580 585 590
Thr Leu Arg Asp Ser Ser Ala Tyr Cys
595 600
<210>155
<211>356
<212>PRT
<213>人
<400> 155
Met Ser Pro Cys Gly Arg Ala Arg Arg Gln Thr Ser Arg Gly Ala Met
1 5 10 15
Ala Val Leu Ala Trp Lys Phe Pro Arg Thr Arg Leu Pro Met Gly Ala
20 25 30
Ser Ala Leu Cys Val Val Val Leu Cys Trp Leu Tyr Ile Phe Pro Val
35 40 45
Tyr Arg Leu Pro Asn Glu Lys Glu Ile Val Gln Gly Val Leu Gln Gln
50 55 60
Gly Thr Ala Trp Arg Arg Asn Gln Thr Ala Ala Arg Ala Phe Arg Lys
65 70 75 80
Gln Met Glu Asp Cys Cys Asp Pro Ala His Leu Phe Ala Met Thr Lys
85 90 95
Met Asn Ser Pro Met Gly Lys Ser Met Trp Tyr Asp Gly Glu Phe Leu
100 105 110
Tyr Ser Phe Thr Ile Asp Asn Ser Thr Tyr Ser Leu Phe Pro Gln Ala
115 120 125
Thr Pro Phe Gln Leu Pro Leu Lys Lys Cys Ala Val Val Gly Asn Gly
130 135 140
Gly Ile Leu Lys Lys Ser Gly Cys Gly Arg Gln Ile Asp Glu Ala Asn
145 150 155 160
Phe Val Met Arg Cys Asn Leu Pro Pro Leu Ser Ser Glu Tyr Thr Lys
165 170 175
Asp Val Gly Ser Lys Ser Gln Leu Val Thr Ala Asn Pro Ser Ile Ile
180 185 190
Arg Gln Arg Phe Gln Asn Leu Leu Trp Ser Arg Lys Thr Phe Val Asp
195 200 205
Asn Met Lys Ile Tyr Asn His Ser Tyr Ile Tyr Met Pro Ala Phe Ser
210 215 220
Met Lys Thr Gly Thr Glu Pro Ser Leu Arg Val Tyr Tyr Thr Leu Ser
225 230 235 240
Asp Val Gly Ala Asn Gln Thr Val Leu Phe Ala Asn Pro Asn Phe Leu
245 250 255
Arg Ser Ile Gly Lys Phe Trp Lys Ser Arg Gly Ile His Ala Lys Arg
260 265 270
Leu Ser Thr Gly Leu Phe Leu Val Ser Ala Ala Leu Gly Leu Cys Glu
275 280 285
Glu Val Ala Ile Tyr Gly Phe Trp Pro Phe Ser Val Asn Met His Glu
290 295 300
Gln Pro Ile Ser His His Tyr Tyr Asp Asn Val Leu Pro Phe Ser Gly
305 310 315 320
Phe His Ala Met Pro Glu Glu Phe Leu Gln Leu Trp Tyr Leu His Lys
325 330 335
Ile Gly Ala Leu Arg Met Gln Leu Asp Pro Cys Glu Asp Thr Ser Leu
340 345 350
Gln Pro Thr Ser
355
<210>156
<211>404
<212>PRT
<213>人
<400>156
Met Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly
1 5 10 15
Tyr Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe
20 25 30
Ala Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala Pro Ala Ser
35 40 45
Val Leu Pro Ala Ala Thr Pro Arg Gln Ser Leu Gly His Pro Pro Pro
50 55 60
Glu Pro Gly Pro Asp Arg Val Ala Asp Ala Lys Gly Asp Ser Glu Ser
65 70 75 80
Glu Glu Asp Glu Asp Leu Glu Val Pro Val Pro Ser Arg Phe Asn Arg
85 90 95
Arg Val Ser Val Cys Ala Glu Thr Tyr Asn Pro Asp Glu Glu Glu Glu
100 105 110
Asp Thr Asp Pro Arg Val lle His Pro Lys Thr Asp Glu Gln Arg Cys
115 120 125
Arg Leu Gln Glu Ala Cys Lys Asp Ile Leu Leu Phe Lys Asn Leu Asp
130 135 140
Gln Glu Gln Leu Ser Gln Val Leu Asp Ala Met Phe Glu Arg Ile Val
145 150 155 160
Lys Ala Asp Glu His Val Ile Asp Gln Gly Asp Asp Gly Asp Asn Phe
165 170 175
Tyr Val Ile Glu Arg Gly Thr Tyr Asp Ile Leu Val Thr Lys Asp Asn
180 185 190
Gln Thr Arg Ser Val Gly Gln Tyr Asp Asn Arg Gly Ser Phe Gly Glu
195 200 205
Leu Ala Leu Met Tyr Asn Thr Pro Arg Ala Ala Thr Ile Val Ala Thr
210 215 220
Ser Glu Gly Ser Leu Trp Gly Leu Asp Arg Val Thr Phe Arg Arg Ile
225 230 235 240
Ile Val Lys Asn Asn Ala Lys Lys Arg Lys Met Phe Glu Ser Phe Ile
245 250 255
Glu Ser Val Pro Leu Leu Lys Ser Leu Glu Val Ser Glu Arg Met Lys
260 265 270
Ile Val Asp Val Ile Gly Glu Lys Ile Tyr Lys Asp Gly Glu Arg Ile
275 280 285
lle Thr Gln Gly Glu Lys Ala Asp Ser Phe Tyr Ile Ile Glu Ser Gly
290 295 300
Glu Val Ser Ile Leu Ile Arg Ser Arg Thr Lys Ser Asn Lys Asp Gly
305 310 315 320
Gly Asn Gln Glu Val Glu Ile Ala Arg Cys His Lys Gly Gln Tyr Phe
325 330 335
Gly Glu Leu Ala Leu Val Thr Asn Lys Pro Arg Ala Ala Ser Ala Tyr
340 345 350
Ala Val Gly Asp Val Lys Cys Leu Val Met Asp Val Gln Ala Phe Glu
355 360 365
Arg Leu Leu Gly Pro Cys Met Asp Ile Met Lys Arg Asn Ile Ser His
370 375 380
Tyr Glu Glu Gln Leu Val Lys Met Phe Gly Ser Ser Val Asp Leu Gly
385 390 395 400
Asn Leu Gly Gln
<210>157
<211>505
<212>PRT
<213>人
<400>157
Met Ser Gly Ala Ser Ser Ser Glu Gln Asn Asn Asn Ser Tyr Glu Thr
1 5 10 15
Lys Thr Pro Asn Leu Arg Met Ser Glu Lys Lys Cys Ser Trp Ala Ser
20 25 30
Tyr Met Thr Asn Ser Pro Thr Leu Ile Val Met Ile Gly Leu Pro Ala
35 40 45
Arg Gly Lys Thr Tyr Val Ser Lys Lys Leu Thr Arg Tyr Leu Asn Trp
50 55 60
Ile Gly Val Pro Thr Lys Val Phe Asn Leu Gly Val Tyr Arg Arg Glu
65 70 75 80
Ala Val Lys Ser Tyr Lys Ser Tyr Asp Phe Phe Arg His Asp Asn Glu
85 90 95
Glu Ala Met Lys Ile Arg Lys Gln Cys Ala Leu Val Ala Leu Glu Asp
100 105 110
Val Lys Ala Tyr Leu Thr Glu Glu Asn Gly Gln Ile Ala Val Phe Asp
115 120 125
Ala Thr Asn Thr Thr Arg Glu Arg Arg Asp Met Ile Leu Asn Phe Ala
130 135v 140
Glu Gln Asn Ser Phe Lys Val Phe Phe Val Glu Ser Val Cys Asp Asp
145 150 155 160
Pro Asp Val Ile Ala Ala Asn Ile Leu Glu Val Lys Val Ser Ser Pro
165 170 175
Asp Tyr Pro Glu Arg Asn Arg Glu Asn Val Met Glu Asp Phe Leu Lys
180 185 190
Arg Ile Glu Cys Tyr Lys Val Thr Tyr Arg Pro Leu Asp Pro Asp Asn
195 200 205
Tyr Asp Lys Asp Leu Ser Phe Ile Lys Val Ile Asn Val Gly Gln Arg
210 215 220
Phe Leu Val Asn Arg Val Gln Asp Tyr Ile Gln Ser Lys Ile Val Tyr
225 230 235 240
Tyr Leu Met Asn Ile His Val Gln Pro Arg Thr Ile Tyr Leu Cys Arg
245 250 255
His Gly Glu Ser Glu Phe Asn Leu Leu Gly Lys Ile Gly Gly Asp Ser
260 265 270
Gly Leu Ser Val Arg Gly Lys Gln Phe Ala Gln Ala Leu Arg Lys Phe
275 280 285
Leu Glu Glu Gln Glu Ile Thr Asp Leu Lys Val Trp Thr Ser Gln Leu
290 295 300
Lys Arg Thr Ile Gln Thr Ala Glu Ser Leu Gly Val Pro Tyr Glu Gln
305 310 315 320
Trp Lys Ile Leu Asn Glu Ile Asp Ala Gly Val Cys Glu Glu Met Thr
325 330 335
Tyr Ala Glu Ile Glu Lys Arg Tyr Pro Glu Glu Phe Ala Leu Arg Asp
340 345 350
Gln Glu Lys Tyr Leu Tyr Arg Tyr Pro Gly Gly Glu Ser Tyr Gln Asp
355 360 365
Leu Val Gln Arg Leu Glu Pro Val Ile Met Glu Leu Glu Arg Gln Gly
370 375 380
Asn Val Leu Val Ile Ser His Gln Ala Val Met Arg Cys Leu Leu Ala
385 390 395 400
Tyr Phe Leu Asp Lys Gly Ala Asp Glu Leu Pro Tyr Leu Arg Cys Pro
405 410 415
Leu His Thr Ile Phe Lys Leu Thr Pro Val Ala Tyr Gly Cys Lys Val
42 425 430
Glu Thr Ile Lys Leu Asn Val Glu Ala Val Asn Thr His Arg Asp Lys
435 440 445
Pro Thr Asn Asn Phe Pro Lys Asn Gln Thr Pro Val Arg Met Arg Arg
450 455 460
Asn Ser Phe Thr Pro Leu Ser Ser Ser Asn Thr Ile Arg Arg Pro Arg
465 470 475 480
Asn Tyr Ser Val Gly Ser Arg Pro Leu Lys Pro Leu Ser Pro Leu Arg
485 490 495
Ala Gln Asp Met Gln Glu Gly Ala Asp
500 505
<210>158
<211>543
<212>PRT
<213>人
<400> 158
Met Met Pro Thr Pro Val Ile Leu Leu Lys Glu Gly Thr Asp Ser Ser
1 5 10 15
Gln Gly Ile Pro Gln Leu Val Ser Asn Ile Ser Ala Cys Gln Val Ile
20 25 30
Ala Glu Ala Val Arg Thr Thr Leu Gly Pro Arg Gly Met Asp Lys Leu
35 40 45
Ile Val Asp Gly Arg Gly Lys Ala Thr Ile Ser Asn Asp Gly Ala Thr
50 55 60
Ile Leu Lys Leu Leu Asp Val Val His Pro Ala Ala Lys Thr Leu Val
65 70 75 80
Asp Ile Ala Lys Ser Gln Asp Ala Glu Val Gly Asp Gly Thr Thr Ser
85 90 95
Val Thr Leu Leu Ala Ala Glu Phe Leu Lys Gln Val Lys Pro Tyr Val
100 105 110
Glu Glu Gly Leu His Pro Gln Ile Ile Ile Arg Ala Phe Arg Thr Ala
115 120 125
Thr Gln Leu Ala Val Asn Lys Ile Lys Glu Ile Ala Val Thr Val Lys
130 135 140
Lys Ala Asp Lys Val Glu Gln Arg Lys Leu Leu Glu Lys Cys Ala Met
145 150 155 160
Thr Ala Leu Ser Ser Lys Leu Ile Ser Gln Gln Lys Ala Phe Phe Ala
165 170 175
Lys Met Val Val Asp Ala Val Met Met Leu Asp Asp Leu Leu Gln Leu
180 185 190
Lys Met Ile Gly Ile Lys Lys Val Gln Gly Gly Ala Leu Glu Asp Ser
195 200 205
Gln Leu Val Ala Gly Val Ala Phe Lys Lys Thr Phe Ser Tyr Ala Gly
210 215 220
300
Phe Glu Met Gln Pro Lys Lys Tyr His Asn Pro Lys Ile Ala Leu Leu
225 230 235 240
Asn Val Glu Leu Glu Leu Lys Ala Glu Lys Asp Asn Ala Glu Ile Arg
245 250 255
Val His Thr Val Glu Asp Tyr Gln Ala Ile Val Asp Ala Glu Trp Asn
260 265 270
Ile Leu Tyr Asp Lys Leu Glu Lys Ile His His Ser Gly Ala Lys Val
275 280 285
Val Leu Ser Lys Leu Pro Ile Gly Asp Val Ala Thr Gln Tyr Phe Ala
290 295 300
Asp Arg Asp Met Phe Cys Ala Gly Arg Val Pro Glu Glu Asp Leu Lys
305 310 315 320
Arg Thr Met Met Ala Cys Gly Gly Ser Ile Gln Thr Ser Val Asn Ala
325 330 335
Leu Ser Ala Asp Val Leu Gly Arg Cys Gln Val Phe Glu Glu Thr Gln
340 345 350
Ile Gly Gly Glu Arg Tyr Asn Phe Phe Thr Gly Cys Pro Lys Ala Lys
355 360 365
Thr Cys Thr Phe Ile Leu Arg Gly Gly Ala Glu Gln Phe Met Glu Glu
370 375 380
Thr Glu Arg Ser Leu His Asp Ala Ile Met Ile Val Arg Arg Ala Ile
385 390 395 400
Lys Asn Asp Ser Val Val Ala Gly Gly Gly Ala Ile Glu Met Glu Leu
405 410 415
Ser Lys Tyr Leu Arg Asp Tyr Ser Arg Thr Ile Pro Gly Lys Gln Gln
420 425 430
Leu Leu Ile Gly Ala Tyr Ala Lys Ala Leu Glu Ile Ile Pro Arg Gln
435 440 445
Leu Cys Asp Asn Ala Gly Phe Asp Ala Thr Asn Ile Leu Asn Lys Leu
450 455 460
Arg Ala Arg His Ala Gln Gly Gly Thr Trp Tyr Gly Val Asp Ile Asn
465 470 475 480
Asn Glu Asp Ile Ala Asp Asn Phe Glu Ala Phe Val Trp Glu Pro Ala
485 490 495
Met Val Arg Ile Asn Ala Leu Thr Ala Ala Ser Glu Ala Ala Cys Leu
500 505 510
Ile Val Ser Val Asp Glu Thr Ile Lys Asn Pro Arg Ser Thr Val Asp
515 520 525
Ala Pro Thr Ala Ala Gly Arg Gly Arg Gly Arg Gly Arg Pro His
530 535 540
<210>159
<211>359
<212>PRT
<21 3>人
<400>159
Met Thr Leu Glu Ser Met Met Ala Cys Cys Leu Ser Asp Glu Val Lys
1 5 10 15
Glu Ser Lys Arg Ile Asn Ala Glu Ile Glu Lys Gln Leu Arg Arg Asp
20 25 30
Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly
35 40 45
Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly
50 55 60
Ala Gly Tyr Ser Glu Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr
65 70 75 80
Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Glu Thr
85 90 95
Leu Lys Ile Leu Tyr Lys Tyr Glu Gln Asn Lys Ala Asn Ala Leu Leu
100 105 110
Ile Arg Glu Val Asp Val Glu Lys Val Thr Thr Phe Glu His Gln Tyr
115 120 125
Val Ser Ala Ile Lys Thr Leu Trp Glu Asp Pro Gly Ile Gln Glu Cys
130 135 140
Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Ala Lys Tyr Tyr
145 150 155 160
Leu Thr Asp Val Asp Arg Ile Ala Thr Leu Gly Tyr Leu Pro Thr Gln
165 170 175
Gln Asp Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr
180 185 190
Pro Phe Asp Leu Glu Asn Ile Ile Phe Arg Met Val Asp Val Gly Gly
195 200 205
Gln Arg Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr
210 215 220
Ser Ile Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val
225 230 235 240
Glu Ser Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg
245 250 255
Thr Ile Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe
260 265 270
Leu Asn Lys Lys Asp Leu Leu Glu Asp Lys Ile Leu Tyr Ser His Leu
275 280 285
Val Asp Tyr Phe Pro Glu Phe Asp Gly Pro Gln Arg Asp Ala Gln Ala
290 295 300
Ala Arg Glu Phe Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser
305 310 315 320
Asp Lys Ile Ile Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn
325 330 335
Ile Arg Phe Val Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn
340 345 350
Leu Lys Glu Tyr Asn Leu Val
355
<210>160
<211>704
<212>PRT
<213>人
<400> 60
Met Ala Asn Glu Asn His Gly Ser Pro Arg Glu Glu Ala Ser Leu Leu
1 5 10 15
Ser His Ser Pro Gly Thr Ser Asn Gln Ser Gln Pro Cys Ser Pro Lys
20 25 30
Pro Ile Arg Leu Val Gln Asp Leu Pro Glu Glu Leu Val His Ala Gly
35 40 45
Trp Glu Lys Cys Trp Ser Arg Arg Glu Asn Arg Pro Tyr Tyr Phe Asn
50 55 60
Arg Phe Thr Asn Gln Ser Leu Trp Glu Met Pro Val Leu Gly Gln His
65 70 75 80
Asp Val Ile Ser Asp Pro Leu Gly Leu Asn Ala Thr Pro Leu Pro Gln
85 90 95
Asp Ser Ser Leu Val Glu Thr Pro Pro Ala Glu Asn Lys Pro Arg Lys
100 105 110
Arg Gln Leu Ser Glu Glu Gln Pro Ser Gly Asn Gly Val Lys Lys Pro
115 120 125
Lys Ile Glu Ile Pro Val Thr Pro Thr Gly Gln Ser Val Pro Ser Ser
130 135 140
Pro Ser Ile Pro Gly Thr Pro Thr Leu Lys Met Trp Gly Thr Ser Pro
145 150 155 160
Glu Asp Lys Gln Gln Ala Ala Leu Leu Arg Pro Thr Glu Val Tyr Trp
165 170 175
Asp Leu Asp Ile Gln Thr Asn Ala Val Ile Lys His Arg Gly Pro Ser
180 185 190
Glu Val Leu Pro Pro His Pro Glu Val Glu Leu Leu Arg Ser Gln Leu
195 200 205
Ile Leu Lys Leu Arg Gln His Tyr Arg Glu Leu Cys Gln Gln Arg Glu
210 215 220
Gly Ile Glu Pro Pro Arg Glu Ser Phe Asn Arg Trp Met Leu Glu Arg
225 230 235 240
Lys Val Val Asp Lys Gly Ser Asp Pro Leu Leu Pro Ser Asn Cys Glu
245 250 255
Pro Val Val Ser Pro Ser Met Phe Arg Glu Ile Met Asn Asp Ile Pro
260 265 270
Ile Arg Leu Ser Arg Ile Lys Phe Arg Glu Glu Ala Lys Arg Leu Leu
275 280 285
Phe Lys Tyr Ala Glu Ala Ala Arg Arg Leu Ile Glu Ser Arg Ser Ala
290 295 300
Ser Pro Asp Ser Arg Lys Val Val Lys Trp Asn Val Glu Asp Thr Phe
305 310 315 320
Ser Trp Leu Arg Lys Asp His Ser Ala Ser Lys Glu Asp Tyr Met Asp
325 330 335
Arg Leu Glu His Leu Arg Arg Gln Cys Gly Pro His Val Ser Ala Ala
340 345 350
Ala Lys Asp Ser Val Glu Gly Ile Cys Ser Lys Ile Tyr His Ile Ser
355 360 365
Leu Glu Tyr Val Lys Arg Ile Arg Glu Lys His Leu Ala Ile Leu Lys
370 375 380
Glu Asn Asn Ile Ser Glu Glu Val Glu Ala Pro Glu Val Glu Pro Arg
385 390 395 400
Leu Val Tyr Cys Tyr Pro Val Arg Leu Ala Val Ser Ala Pro Pro Met
405 410 415
Pro Ser Val Glu Met His Met Glu Asn Asn Val Val Cys Ile Arg Tyr
420 425 430
Lys Gly Glu Met Val Lys Val Ser Arg Asn Tyr Phe Ser Lys Leu Trp
435 440 445
Leu Leu Tyr Arg Tyr Ser Cys Ile Asp Asp Ser Ala Phe Glu Arg Phe
450 455 460
Leu Pro Arg Val Trp Cys Leu Leu Arg Arg Tyr Gln Met Met Phe Gly
465 470 475 480
Val Gly Leu Tyr Glu Gly Thr Gly Leu Gln Gly Ser Leu Pro Val His
485 490 495
Val Phe Glu Ala Leu His Arg Leu Phe Gly Val Ser Phe Glu Cys Phe
500 505 510
Ala Ser Pro Leu Asn Cys Tyr Phe Arg Gln Tyr Cys Ser Ala Phe Pro
515 520 525
Asp Thr Asp Gly Tyr Phe Gly Ser Arg Gly Pro Cys Leu Asp Phe Ala
530 535 540
Pro Leu Ser Gly Ser Phe Glu Ala Asn Pro Pro Phe Cys Glu Glu Leu
545 550 555 560
Met Asp Ala Met Val Ser His Phe Glu Arg Leu Leu Glu Ser Ser Pro
565 570 575
Glu Pro Leu Ser Phe Ile Val Phe Ile Pro Glu Trp Arg Glu Pro Pro
580 585 590
Thr Pro Ala Leu Thr Arg Met Glu Gln Ser Arg Phe Lys Arg His Gln
595 600 605
Leu Ile Leu Pro Ala Phe Glu His Glu Tyr Arg Ser Gly Ser Gln His
610 615 620
Ile Cys Lys Lys Glu Glu Met His Tyr Lys Ala Val His Asn Thr Ala
625 630 635 640
Val Leu Phe Leu Gln Asn Asp Pro G1y Phe Ala Lys Trp Ala Pro Thr
645 650 655
Pro Glu Arg Leu Gln Glu Leu Ser Ala Ala Tyr Arg Gln Ser Gly Arg
660 665 670
Ser His Ser Ser Gly Ser Ser Ser Ser Ser Ser Ser Glu Ala Lys Asp
675 680 685
Arg Asp Ser Gly Arg Glu Gln Gly Pro Ser Arg Glu Pro His Pro Thr
690 695 700
<210>161
<211>573
<212>PRT
<213>人
<400>161
Met Leu Gly Ser Leu Gly Leu Trp Ala Leu Leu Pro Thr Ala Val Glu
5 10 15
Ala Pro Pro Asn Arg Arg Thr Cys Val Phe Phe Glu Ala Pro Gly Val
20 25 30
Arg Gly Ser Thr Lys Thr Leu Gly Glu Leu Leu Asp Thr Gly Thr Glu
35 40 45
Leu Pro Arg Ala Ile Arg Cys Leu Tyr Ser Arg Cys Cys Phe Gly Ile
50 55 60
Trp Asn Leu Thr Gln Asp Arg Ala Gln Val Glu Met Gln Gly Cys Arg
65 70 75 80
Asp Ser Asp Glu Pro Gly Cys Glu Ser Leu His Cys Asp Pro Ser Pro
85 90 95
Arg Ala His Pro Ser Pro Gly Ser Thr Leu Phe Thr Cys Ser Cys Gly
100 105 110
Thr Asp Phe Cys Asn Ala Asn Tyr Ser His Leu Pro Pro Pro Gly Ser
115 120 125
Pro Gly Thr Pro Gly Ser Gln Gly Pro Gln Ala Ala Pro Gly Glu Ser
130 135 140
lle Trp Met Ala Leu Val Leu Leu Gly Leu Phe Leu Leu Leu Leu Leu
145 150 155 160
Leu Leu Gly Ser Ile Ile Leu Ala Leu Leu Gln Arg Lys Asn Tyr Arg
165 170 175
Val Arg Gly Glu Pro Val Pro Glu Pro Arg Pro Asp Ser Gly Arg Asp
180 185 190
Trp Ser Val Glu Leu Gln Glu Leu Pro Glu Leu Cys Phe Ser Gln Val
195 200 205
lle Arg Glu Gly Gly His Ala Val Val Trp Ala Gly Gln Leu Gln Gly
210 215 220
Lys Leu Val Ala Ile Lys Ala Phe Pro Pro Arg Ser Val Ala Gln Phe
225 230 235 240
Gln Ala Glu Arg Ala Leu Tyr Glu Leu Pro Gly Leu Gln His Asp His
245 250 255
Ile Val Arg Phe Ile Thr Ala Ser Arg Gly Gly Pro Gly Arg Leu Leu
260 265 270
Ser Gly Pro Leu Leu Val Leu Glu Leu His Pro Lys Gly Ser Leu Cys
275 280 285
His Tyr Leu Thr Gln Tyr Thr Ser Asp Trp Gly Ser Ser Leu Arg Met
290 295 300
Ala Leu Ser Leu Ala Gln Gly Leu Ala Phe Leu His Glu Glu Arg Trp
305 310 315 320
Gln Asn Gly Gln Tyr Lys Pro Gly Ile Ala His Arg Asp Leu Ser Ser
325 330 335
Gln Asn Val Leu Ile Arg Glu Asp Gly Ser Cys Ala Ile Gly Asp Leu
340 345 350
Gly Leu Ala Leu Val Leu Pro Gly Leu Thr Gln Pro Pro Ala Trp Thr
355 360 365
Pro Thr Gln Pro Gln Gly Pro Ala Ala Ile Met Glu Ala Gly Thr Gln
370 375 380
Arg Tyr Met Ala Pro Glu Leu Leu Asp Lys Thr Leu Asp Leu Gln Asp
385 390 395 400
Trp Gly Met Ala Leu Arg Arg Ala Asp Ile Tyr Ser Leu Ala Leu Leu
405 410 415
Leu Trp Glu Ile Leu Ser Arg Cys Pro Asp Leu Arg Pro Asp Ser Ser
420 425 430
Pro Pro Pro Phe Gln Leu Ala Tyr Glu Ala Glu Leu Gly Asn Thr Pro
435 440 445
Thr Ser Asp Glu Leu Trp Ala Leu Ala Val Gln Glu Arg Arg Arg Pro
450 455 460
Tyr Ile Pro Ser Thr Trp Arg Cys Phe Ala Thr Asp Pro Asp Gly Leu
465 470 475 480
Arg Glu Leu Leu Glu Asp Cys Trp Asp Ala Asp Pro Glu Ala Arg Leu
485 490 495
Thr Ala Glu Cys Val Gln Gln Arg Leu Ala Ala Leu Ala His Pro Gln
500 505 510
Glu Ser His Pro Phe Pro Glu Ser Cys Pro Arg Gly Cys Pro Pro Leu
515 520 525
Cys Pro Glu Asp Cys Thr Ser Ile Pro Ala Pro Thr Ile Leu Pro Cys
530 535 540
Arg Pro Gln Arg Ser Ala Cys His Phe Ser Val Gln Gln Gly Pro Cys
545 550 555 560
Ser Arg Asn Pro Gln Pro Ala Cys Thr Leu Ser Pro Val
565 570
<210>162
<211>402
<212>PRT
<213>人
<400>162
Met Gly Leu Gly Gln Gly Trp Gly Trp Glu Ala Ser Cys Phe Ala Cys
5 10 15
Leu Ile Arg Ser Cys Cys Gln Val Val Thr Phe Thr Phe Pro Phe Gly
20 25 30
Phe Gln Gly Ile Ser Gln Arg Leu Glu Asn Val Ser Gly Tyr Tyr Ala
35 40 45
Asp Ala Arg Leu Glu Val Gly Ser Thr Gln Leu Arg Thr Ala Gly Ser
50 55 60
Cys Ser His Ser Phe Lys Arg Ser Phe Leu Glu Lys Lys Arg Phe Thr
65 70 75 80
Glu Glu Ala Thr Lys Tyr Phe Arg Glu Arg Val Ser Pro Val His Leu
85 90 95
Gln Ile Leu Leu Thr Asn Asn Glu Ala Trp Lys Arg Phe Val Thr Ala
100 105 110
Ala Glu Leu Pro Arg Asp Glu Ala Asp Ala Leu Tyr Glu Ala Leu Lys
115 120 125
Lys Leu Arg Thr Tyr Ala Ala Ile Glu Asp Glu Tyr Val Gln Gln Lys
130 135 140
Asp Glu Gln Phe Arg Glu Trp Phe Leu Lys Glu Phe Pro Gln Val Lys
145 150 155 160
Arg Lys Ile Gln Glu Ser Ile Glu Lys Leu Arg Ala Leu Ala Asn Gly
165 170 175
Ile Glu Glu Val His Arg Gly Cys Thr Ile Ser Asn Val Val Ser Ser
180 185 190
Ser Thr Gly Ala Ala Ser Gly Ile Met Ser Leu Ala Gly Leu Val Leu
195 200 205
Ala Pro Phe Thr Ala Gly Thr Ser Leu Ala Leu Thr Ala Ala Gly Val
210 215 220
Gly Leu Gly Ala Ala Ser Ala Val Thr Gly Ile Thr Thr Ser Ile Val
225 230 235 240
Glu His Ser Tyr Thr Ser Ser Ala Glu Ala Glu Ala Ser Arg Leu Thr
245 250 255
Ala Thr Ser Ile Asp Arg Leu Lys Val Phe Lys Glu Val Met Arg Asp
260 265 270
Ile Thr Pro Asn Leu Leu Ser Leu Leu Ash Asn Tyr Tyr Glu Ala Thr
275 280 285
Gln Thr Ile Gly Ser Glu Ile Arg Ala Ile Arg Gln Ala Arg Ala Arg
290 295 300
Ala Arg Leu Pro Val Thr Thr Trp Arg Ile Ser Ala Gly Ser Gly Gly
305 310 315 320
Gln Ala Glu Arg Thr Ile Ala Gly Thr Thr Arg Ala Val Ser Arg Gly
325 330 335
Ala Arg Ile Leu Ser Ala Thr Thr Ser Gly Ile Phe Leu Ala Leu Asp
340 345 350
Val Val Asn Leu Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys
355 360 365
Ser Ala Ser Ala Glu Glu Leu Arg Arg Gln Ala Gln Glu Leu Glu Glu
370 375 380
Asn Leu Met Glu Leu Thr Gln Ile Tyr Gln Arg Leu Asn Pro Cys His
385 390 395 400
Thr His
<210>163
<211>326
<212>PRT
<213>人
<400>163
Met Ala Leu Ser Gly Ser Thr Pro Ala Pro Cys Trp Glu Glu Asp Glu
1 5 10 15
Gys Leu Asp Tyr Tyr Gly Met Leu Ser Leu His Arg Met Phe Glu Val
20 25 30
Val Gly Gly Gln Leu Thr Glu Cys Glu Leu Glu Leu Leu Ala Phe Leu
35 40 45
Leu Asp Glu Ala Pro Gly Ala Ala Gly Gly Leu Ala Arg Ala Arg Ser
50 55 60
Gly Leu Glu Leu Leu Leu Glu Leu Glu Arg Arg Gly Gln Cys Asp Glu
65 70 75 80
Ser Asn Leu Arg Leu Leu Gly Gln Leu Leu Arg Val Leu Ala Arg His
85 90 95
Asp Leu Leu Pro His Leu Ala Arg Lys Arg Arg Arg Pro Val Ser Pro
100 105 110
Glu Arg Tyr Ser Tyr Gly Thr Ser Ser Ser Ser Lys Arg Thr Glu Gly
115 120 125
Ser Cys Arg Arg Arg Arg Gln Ser Ser Ser Ser Ala Asn Ser Gln Gln
130 135 140
Gly Gln Trp Glu Thr Gly Ser Pro Pro Thr Lys Arg Gln Arg Arg Ser
145 150 155 160
Arg Gly Arg Pro Ser Gly Gly Ala Arg Arg Arg Arg Arg Gly Ala Pro
165 170 175
Ala Ala Pro Gln Gln Gln Ser Glu Pro Ala Arg Pro Ser Ser Glu Gly
180 185 190
Lys Val Thr Cys Asp Ile Arg Leu Arg Val Arg Ala Glu Tyr Cys Glu
195 200 205
His Gly Pro Ala Leu Glu Gln Gly Val Ala Ser Arg Arg Pro Gln Ala
210 215 220
Leu Ala Arg Gln Leu Asp Val Phe Gly Gln Ala Thr Ala Val Leu Arg
225 230 235 240
Ser Arg Asp Leu Gly Ser Val Val Cys Asp Ile Lys Phe Ser Glu Leu
245 250 255
Ser Tyr Leu Asp Ala Phe Trp Gly Asp Tyr Leu Ser Gly Ala Leu Leu
260 265 270
Gln Ala Leu Arg Gly Val Phe Leu Thr Glu Ala Leu Arg Glu Ala Val
275 280 285
Gly Arg Glu Ala Val Arg Leu Leu Val Ser Val Asp Glu Ala Asp Tyr
290 295 300
Glu Ala Gly Arg Arg Arg Leu Leu Leu Met Glu Glu Glu Gly Gly Arg
305 310 315 320
Arg Pro Thr Glu Ala Ser
325
<210>164
<211>556
<212>PRT
<213>人
<400>164
Met Glu Leu Cys Gly Leu Gly Leu Pro Arg Pro Pro Met Leu Leu Ala
1 5 10 15
Leu Leu Leu Ala Thr Leu Leu Ala Ala Met Leu Ala Leu Leu Thr Gln
20 25 30
Val Ala Leu Val Val Gln Val Ala Glu Ala Ala Arg Ala Pro Ser Val
35 40 45
Ser Ala Lys Pro Gly Pro Ala Leu Trp Pro Leu Pro Leu Ser Val Lys
50 55 60
Met Thr Pro Asn Leu Leu His Leu Ala Pro Glu Asn Phe Tyr Ile Ser
65 70 75 80
His Ser Pro Asn Ser Thr Ala Gly Pro Ser Cys Thr Leu Leu Glu Glu
85 90 95
Ala Phe Arg Arg Tyr His Gly Tyr Ile Phe Gly Phe Tyr Lys Trp His
100 105 110
His Glu Pro Ala Glu Phe Gln Ala Lys Thr Gln Val Gln Gln Leu Leu
115 120 125
Val Ser Ile Thr Leu Gln Ser Glu Cys Asp Ala Phe Pro Asn Ile Ser
130 135 140
Ser Asp Glu Ser Tyr Thr Leu Leu Val Lys Glu Pro Val Ala Val Leu
145 150 155 160
Lys Ala Asn Arg Val Trp Gly Ala Leu Arg Gly Leu Glu Thr Phe Ser
165 170 175
Gln Leu Val Tyr Gln Asp Ser Tyr Gly Thr Phe Thr Ile Asn Glu Ser
180 185 190
Thr Ile Ile Asp Ser Pro Arg Phe Ser Hi s Arg Gly Ile Leu Ile Asp
195 200 205
Thr Ser Arg His Tyr Leu Pro Val Lys Ile Ile Leu Lys Thr Leu Asp
210 215 220
Ala Met Ala Phe Asn Lys Phe Asn Val Leu His Trp His Ile Val Asp
225 230 235 240
Asp Gln Ser Phe Pro Tyr Gln Ser Ile Thr Phe Pro Glu Leu Ser Asn
245 250 255
Lys Gly Ser Tyr Ser Leu Ser His Val Tyr Thr Pro Asn Asp Val Arg
260 265 270
Met Val Ile Glu Tyr Ala Arg Leu Arg Gly Ile Arg Val Leu Pro Glu
275 280 285
Phe Asp Thr Pro Gly His Thr Leu Ser Trp Gly Lys Gly Gln Lys Asp
290 295 300
Leu Leu Thr Pro Cys Tyr Ser Arg Gln Asn Lys Leu Asp Ser Phe Gly
305 310 315 320
Pro Ile Asn Pro Thr Leu Asn Thr Thr Tyr Ser Phe Leu Thr Thr Phe
325 330 335
Phe Lys Glu Ile Ser Glu Val Phe Pro Asp Gln Phe Ile His Leu Gly
340 345 350
Gly Asp Glu Val Glu Phe Lys Cys Trp Glu Ser Asn Pro LysIle Gln
355 360 365
Asp Phe Met Arg Gln Lys Gly Phe Gly Thr Asp Phe Lys Lys Leu Glu
370 375 380
Ser Phe Tyr Ile Gln Lys Val Leu Asp Ile Ile Ala Thr Ile Asn Lys
385 390 395 400
Gly Ser Ile Val Trp Gln Glu Val Phe Asp Asp Lys Ala Lys Leu Ala
405 410 415
Pro Gly Thr Ile Val Glu Val Trp Lys Asp Ser Ala Tyr Pro Glu Glu
420 425 430
Leu Ser Arg Val Thr Ala Ser Gly Phe Pro Val Ile Leu Ser Ala Pro
435 440 445
Trp Tyr Leu Asp Leu Ile Ser Tyr Gly Gln Asp Trp Arg Lys Tyr Tyr
450 455 460
Lys Val Glu Pro Leu Asp Phe Gly Gly Thr Gln Lys Gln Lys Gln Leu
465 470 475 480
Phe Ile Gly Gly Glu Ala Cys Leu Trp Gly Glu Tyr Val Asp Ala Thr
485 490 495
Asn Leu Thr Pro Arg Leu Trp Pro Arg Ala Ser Ala Val Gly Glu Arg
500 505 510
Leu Trp Ser Ser Lys Asp Val Arg Asp Met Asp Asp Ala Tyr Asp Arg
515 520 525
Leu Thr Arg His Arg Cys Arg Met Val Glu Arg Gly Ile Ala Ala Gln
530 535 540
Pro Leu Tyr Ala Gly Tyr Cys Asn His Glu Asn Met
545 550 555
<210>165
<211>463
<212>PRT
<213>人
<400>165
Met Glu Thr Glu Gln Pro Glu Glu Thr Phe Pro Asn Thr Glu Thr Asn
1 5 10 15
Gly Glu Phe Gly Lys Arg Pro Ala Glu Asp Met Glu Glu Glu Gln Ala
20 25 30
Phe Lys Arg Ser Arg Asn Thr Asp Glu Met Val Glu Leu Arg Ile Leu
35 40 45
Leu Gln Ser Lys Asn Ala Gly Ala Val Ile Gly Lys Gly Gly Lys Asn
50 55 60
Ile Lys Ala Leu Arg Thr Asp Tyr Asn Ala Ser Val Ser Val Pro Asp
65 70 75 80
Ser Ser Gly Pro Glu Arg Ile Leu Ser Ile Ser Ala Asp Ile Glu Thr
85 90 95
Ile Gly Glu Ile Leu Lys Lys Ile Ile Pro Thr Leu Glu Glu Gly Leu
100 105 110
Gln Leu Pro Ser Pro Thr Ala Thr Ser Gln Leu Pro Leu Glu Ser Asp
115 120 125
Ala Val Glu Cys Leu Asn Tyr Gln His Tyr Lys Gly Ser Asp Phe Asp
130 135 140
Cys Glu Leu Arg Leu Leu Ile His Gln Ser Leu Ala Gly Gly Ile Ile
145 150 155 160
Gly Val Lys Gly Ala Lys Ile Lys Glu Leu Arg Glu Asn Thr Gln Thr
165 170 175
Thr Ile Lys Leu Phe Gln Glu Cys Cys Pro His Ser Thr Asp Arg Val
180 185 190
Val Leu Ile Gly Gly Lys Pro Asp Arg Val Val Glu Cys Ile Lys Ile
195 200 205
Ile Leu Asp Leu Ile Ser Glu Ser Pro Ile Lys Gly Arg Ala Gln Pro
210 215 220
Tyr Asp Pro Asn Phe Tyr Asp Glu Thr Tyr Asp Tyr Gly Gly Phe Thr
225 230 235 240
Met Met Phe Asp Asp Arg Arg Gly Arg Pro Val Gly Phe Pro Met Arg
245 250 255
Gly Arg Gly Gly Phe Asp Arg Met Pro Pro Gly Arg Gly Gly Arg Pro
260 265 270
Met Pro Pro Ser Arg Arg Asp Tyr Asp Asp Met Ser Pro Arg Arg Gly
275 280 285
Pro Pro Pro Pro Pro Pro Gly Arg Gly Gly Arg Gly Gly Ser Arg Ala
290 295 300
Arg Asn Leu Pro Leu Pro Pro Pro Pro Pro Pro Arg Gly Gly Asp Leu
305 310 315 320
Met Ala Tyr Asp Arg Arg Gly Arg Pro Gly Asp Arg Tyr Asp Gly Met
325 330 335
Val Gly Phe Ser Ala Asp Glu Thr Trp Asp Ser Ala Ile Asp Thr Trp
340 345 350
Ser Pro Ser Glu Trp Gln Met Ala Tyr Glu Pro Gln Gly Gly Ser Gly
355 360 365
Tyr Asp Tyr Ser Tyr Ala Gly Gly Arg Gly Ser Tyr Gly Asp Leu Gly
370 375 380
Gly Pro Ile Ile Thr Thr Gln Val Thr Ile Pro Lys Asp Leu Ala Gly
385 390 395 400
Ser Ile Ile Gly Lys Gly Gly Gln Arg Ile Lys Gln Ile Arg His Glu
405 410 415
Ser Gly Ala Ser Ile Lys Ile Asp Glu Pro Leu Glu Gly Ser Glu Asp
420 425 430
Arg Ile Ile Thr Ile Thr Gly Thr Gln Asp Gln Ile Gln Asn Ala Gln
435 440 445
Tyr Leu Leu Gln Asn Ser Val Lys Gln Tyr Ser Gly Lys Phe Phe
450 455 460
<210>166
<211>538
<212>PRT
<213>人
<400>166
Met Thr Thr Pro Gly Lys Glu Asn Phe Arg Leu Lys Ser Tyr Lys Asn
1 5 10 15
Lys Ser Leu Asn Pro Asp Glu Met Arg Arg Arg Arg Glu Glu Glu Gly
20 25 30
Leu Gln Leu Arg Lys Gln Lys Arg Glu Glu Gln Leu Phe Lys Arg Arg
35 40 45
Asn Val Ala Thr Ala Glu Glu Glu Thr Glu Glu Glu Val Met Ser Asp
50 55 60
Gly Gly Phe His Glu Ala Gln Ile Asn Asn Met Glu Met Ala Pro Gly
65 70 75 80
Gly Val Ile Thr Ser Asp Met Ile Glu Met Ile Phe Ser Lys Ser Pro
85 90 95
Glu Gln Gln Leu Ser Ala Thr Gln Lys Phe Arg Lys Leu Leu Ser Lys
100 105 110
Glu Pro Asn Pro Pro Ile Asp Glu Val Ile Ser Thr Pro Gly Val Val
115 120 125
Ala Arg Phe Val Glu Phe Leu Lys Arg Lys Glu Asn Cys Thr Leu Gln
130 135 140
Phe Glu Ser Ala Trp Val Leu Thr Asn Ile Ala Ser Gly Asn Ser Leu
145 150 155 160
Gln Thr Arg Ile Val Ile Gln Ala Gly Ala Val Pro Ile Phe Ile Glu
165 170 175
Leu Leu Ser Ser Glu Phe Glu Asp Val Gln Glu Gln Ala Val Trp Ala
180 185 190
Leu Gly Asn Ile Ala Gly Asp Ser Thr Met Cys Arg Asp Tyr Val Leu
195 200 205
Asp Cys Asn Ile Leu Pro Pro Leu Leu Gln Leu Phe Ser Lys Gln Asn
210 215 220
Arg Leu Thr Met Thr Arg Asn Ala Val Trp Ala Leu Ser Asn Leu Cys
225 230 235 240
Arg Gly Lys Ser Pro Pro Pro Glu Phe Ala Lys Val Ser Pro Cys Leu
245 250 255
Asn Val Leu Ser Trp Leu Leu Phe Val Ser Asp Thr Asp Val Leu Ala
260 265 270
Asp Ala Cys Trp Ala Leu Ser Tyr Leu Ser Asp Gly Pro Asn Asp Lys
275 280 285
Ile Gln Ala Val Ile Asp Ala Gly Val Cys Arg Arg Leu Val Glu Leu
290 295 300
Leu Met His Asn Asp Tyr Lys Val Val Ser Pro Ala Leu Arg Ala Val
305 310 315 320
Gly Asn Ile Val Thr Gly Asp Asp Ile Gln Thr Gln Val Ile Leu Asn
325 330 335
Cys Ser Ala Leu Gln Ser Leu Leu His Leu Leu Ser Ser Pro Lys Glu
340 345 350
Ser Ile Lys Lys Glu Ala Cys Trp Thr Ile Ser Asn Ile Thr Ala Gly
355 360 365
Asn Arg Ala Gln Ile Gln Thr Val Ile Asp Ala Asn Ile Phe Pro Ala
370 375 380
Leu Ile Ser Ile Leu Gln Thr Ala Glu Phe Arg Thr Arg Lys Glu Ala
385 390 395 400
Ala Trp Ala Ile Thr Asn Ala Thr Ser Gly Gly Ser Ala Glu Gln Ile
405 410 415
Lys Tyr Leu Val Glu Leu Gly Cys Ile Lys Pro Leu Cys Asp Leu Leu
420 425 430
Thr Val Met Asp Ser Lys Ile Val Gln Val Ala Leu Asn Gly Leu Glu
435 440 445
Asn Ile Leu Arg Leu Gly Glu Gln Glu Ala Lys Arg Asn Gly Thr Gly
450 455 460
Ile Asn Pro Tyr Cys Ala Leu Ile Glu Glu Ala Tyr Gly Leu Asp Lys
465 470 475 480
Tle Glu Phe Leu Gln Ser His Glu Asn Gln Glu Ile Tyr Gln Lys Ala
485 490 495
Phe Asp Leu Ile Glu His Tyr Phe Gly Thr Glu Asp Glu Asp Ser Ser
500 505 510
Ile Ala Pro Gln Val Asp Leu Asn Gln Gln Gln Tyr Ile Phe Gln Gln
515 520 525
Cys Glu Ala Pro Met Glu Gly Phe Gln Leu
530 535
<210>167
<211>261
<212>PRT
<213>人
<400>167
Met Asn Pro Asn Cys Ala Arg Cys Gly Lys Ile Val Tyr Pro Thr Glu
1 5 10 15
Lys Val Asn Cys Leu Asp Lys Phe Trp His Lys Ala Cys Phe His Cys
20 25 30
Glu Thr Cys Lys Met Thr Leu Asn Met Lys Asn Tyr Lys Gly Tyr Glu
35 40 45
Lys Lys Pro Tyr Cys Asn Ala His Tyr Pro Lys Gln Ser Phe Thr Met
50 55 60
Val Ala Asp Thr Pro Glu Asn Leu Arg Leu Lys Gln Gln Ser Glu Leu
65 70 75 80
Gln Ser Gln Val Arg Tyr Lys Glu Glu Phe Glu Lys Asn Lys Gly Lys
85 90 95
Gly Phe Ser Val Val Ala Asp Thr Pro Glu Leu Gln Arg Ile Lys Lys
100 105 110
Thr Gln Asp Gln Ile Ser Asn Ile Lys Tyr His Glu Glu Phe Glu Lys
115 120 125
Ser Arg Met Gly Pro Ser Gly Gly Glu Gly Met Glu Pro Glu Arg Arg
130 135 140
Asp Ser Gln Asp Gly Ser Ser Tyr Arg Arg Pro Leu Glu Gln Gln Gln
145 150 155 160
Pro His His Ile Pro Thr Ser Ala Pro Val Tyr Gln Gln Pro Gln Gln
165 170 175
Gln Pro Val Ala Gln Ser Tyr Gly Gly Tyr Lys Glu Pro Ala Ala Pro
180 185 190
Val Ser Ile Gln Arg Ser Ala Pro Gly Gly Gly Gly Lys Arg Tyr Arg
195 200 205
Ala Val Tyr Asp Tyr Ser Ala Ala Asp Glu Asp Glu Val Ser Phe Gln
210 215 220
Asp Gly Asp Thr Ile Val Asn Val Gln Gln Ile Asp Asp Gly Trp Met
225 230 235 240
Tyr Gly Thr Val Glu Arg Thr Gly Asp Thr Gly Met Leu Pro Ala Asn
245 250 255
Tyr Val Glu Ala Ile
260
<210>168
<211>372
<212>PRT
<213>人
<400>168
Met Ser Leu Arg Cys Gly Asp Ala Ala Arg Thr Leu Gly Pro Arg Val
1 5 10 15
Phe Gly Arg Tyr Phe Cys Ser Pro Val Arg Pro Leu Ser Ser Leu Pro
20 25 30
Asp Lys Lys Lys Glu Leu Leu Gln Asn Gly Pro Asp Leu Gln Asp Phe
35 40 45
Val Ser Gly Asp Leu Ala Asp Arg Ser Thr Trp Asp Glu Tyr Lys Gly
50 55 60
Asn Leu Lys Arg Gln Lys Gly Glu Arg Leu Arg Leu Pro Pro Trp Leu
65 70 75 80
Lys Thr Glu Ile Pro Met Gly Lys Asn Tyr Asn Lys Leu Lys Asn Thr
85 90 95
Leu Arg Asn Leu Asn Leu His Thr Val Cys Glu Glu Ala Arg Cys Pro
100 105 110
Asn Ile Gly Glu Cys Trp Gly Gly Gly Glu Tyr Ala Thr Ala Thr Ala
115 120 125
Thr Ile Met Leu Met Gly Asp Thr Cys Thr Arg Gly Cys Arg Phe Cys
130 135 140
Ser Val Lys Thr Ala Arg Asn Pro Pro Pro Leu Asp Ala Ser Glu Pro
145 150 155 160
Tyr Asn Thr Ala Lys Ala Ile Ala Glu Trp Gly Leu Asp Tyr Val Val
165 170 175
Leu Thr Ser Val Asp Arg Asp Asp Mer Pro Asp Gly Gly Ala Glu His
180 185 190
Ile Ala Lys Thr Val Ser Tyr Leu Lys Glu Arg Asn Pro Lys Ile Leu
195 200 205
Val Glu Cys Leu Thr Pro Asp Phe Arg Gly Asp Leu Lys Ala Ile Glu
210 215 220
Lys Val Ala Leu Ser Gly Leu Asp Val Tyr Ala His Asn Val Glu Thr
225 230 235 240
Val Pro Glu Leu Gln Ser Lys Val Arg Asp Pro Arg Val Asn Phe Asp
245 250 255
Gln Ser Leu Arg Val Leu Lys His Ala Lys Lys Val Gln Pro Asp Val
260 265 270
Ile Ser Lys Thr Ser Ile Met Leu Gly Leu Gly Glu Asn Asp Glu Gln
275 280 285
Val Tyr Ala Thr Met Lys Ala Leu Arg Glu Ala Asp Val Asp Cys Leu
290 295 300
Thr Leu Gly Gln Tyr Met Gln Pro Thr Arg Arg His Leu Lys Val Glu
305 310 315 320
Glu Tyr Ile Thr Pro Glu Lys Phe Lys Tyr Trp Glu Lys Val Gly Asn
325 330 335
Glu Leu Gly Phe His Tyr Thr Ala Ser Gly Pro Leu Val Arg Ser Ser
340 345 350
Tyr Lys Ala Gly Glu Phe Phe Leu Lys Asn Leu Val Ala Lys Arg Lys
355 360 365
Thr Lys Asp Leu
370
<210>169
<211>643
<212>PRT
<213>人
<400>169
Met Leu Leu Pro Cys His Trp Val Leu Asp Ala Thr Phe Ser Asp Gly
1 5 10 15
Ser Leu Gly Gln Trp Val Lys Asn Thr Cys Ala Thr Tyr Ala Leu Ser
20 25 30
Pro Val Val Leu Pro Pro Gln Pro Gln Pro Arg Lys Lys Ala Thr Asp
35 40 45
Lys Asp Tyr Ser Ala Phe His Leu Gly His Leu Arg Glu Val Arg Leu
50 55 60
Phe Leu Arg Gly Gly Thr Ser Asp Gln Arg Met Asp Ser Leu Val Leu
65 70 75 80
Cys Pro Thr Tyr Phe Lys Leu Trp Arg Thr Leu Ser Gly Ser Pro Gly
85 90 95
Leu Gln Leu Ser Asp Leu His Phe Gly Ser Gln Pro Glu Gly Lys Phe
100 105 110
Ser Leu Arg Arg Ala Val Ser Val Lys Gln Arg Glu Glu Pro Gln Asp
115 120 125
Trp Pro Leu Asn Glu Lys Arg Thr Leu Trp Lys Asp Ser Asp Leu Pro
130 135 140
Thr Trp Arg Arg Gly Thr Gly Tyr Thr Leu Ser Leu Pro Ala Val Ser
145 150 155 160
Pro Gly Lys Arg Leu Trp Gly Glu Lys Ala Gly Ser Leu Pro Glu Ser
165 170 175
Glu Pro Leu Phe Thr Tyr Thr Leu Asp Glu Lys Val Asp Lys Leu Val
180 185 190
Gln Phe Leu Leu Leu Lys Tyr Gln Ala Lys Glu Pro Leu Thr Arg Ala
195 200 205
Glu Met Gln Met Asn Val Ile Asn Thr Tyr Thr Gly Tyr Phe Pro Met
210 215 220
Ile Phe Arg Lys Ala Arg Glu Phe Ile Glu Ile Leu Phe Gly Ile Ser
225 230 235 240
Leu Thr Glu Val Asp Pro Asp His Phe Tyr Val Phe Val Asn Thr Leu
245 250 255
Asp Leu Thr Cys Glu Gly Ser Leu Ser Asp Glu Gln Gly Met Pro Gln
260 265 270
Asn Arg Leu Leu Ile Leu Ile Leu Ser Val Ile Phe Ile Lys Gly Asn
275 280 285
Cys Ala Ser Glu Glu Val Ile Trp Glu Val Leu Asn Ala Ile Gly Pro
290 295 300
Trp Ser Ala Leu Ala Gly Phe Ala Asp Val Leu Ser Arg Leu Ala Leu
305 310 315 320
Trp Glu Ser Glu Gly Pro Glu Ala Phe Cys Glu Glu Ser Gly Leu Arg
325 330 335
Ser Ala Glu Gly Ser Val Leu Asp Leu Ala Asn Pro Gln Gly Leu Ala
340 345 350
Gly His Arg Gln Glu Asp Gly Arg Arg Gly Leu Thr Glu Ala Ser Pro
355 360 365
Gln Gln Lys Lys Gly Gly Glu Asp Glu Asp Met Pro Ala Ala Gly Met
370 375 380
Pro Pro Leu Pro Gln Ser Pro Pro Glu Ile Pro Pro Gln Gly Pro Pre
385 390 395 400
Lys Ile Ser Pro Gln Gly Pro Pro Gln Ser Pro Pro Gln Ser Pro Leu
405 410 415
Asp Ser Cys Ser Ser Pro Leu Leu Trp Thr Arg Leu Asp Glu Glu Ser
420 425 430
Ser Ser Glu Glu Glu Asp Thr Ala Thr Trp His Ala Leu Pro Glu Ser
435 440 445
Glu Ser Leu Pro Arg Tyr Ala Leu Asp Glu Lys Val Ala Glu Leu Val
450 455 460
Gln Phe Leu Leu Leu Lys Tyr Gln Thr Lys Glu Pro Val Thr Lys Ala
465 470 475 480
Glu Met Leu Thr Thr Val Ile Lys Lys Tyr Lys Asp Tyr Phe Pro Met
485 490 495
Ile Phe Gly Lys Ala His Glu Phe Ile Glu Leu Ile Phe Gly Ile Ala
500 505 510
Leu Thr Asp Met Asp Pro Asp Asn His Ser Tyr Phe Phe Glu Asp Thr
515 520 525
Leu Asp Leu Thr Tyr Glu Gly Ser Leu Ile Asp Asp Gln Gly Met Pro
530 535 540
Lys Asn Cys Leu Leu Ile Leu Ile Leu Ser Met Ile Phe Ile Lys Gly
545 550 555 560
Ser Cys Val Pro Glu Glu Val Ile Trp Glu Val Leu Ser Ala Ile Gly
565 570 575
Pro Ile Gln Arg Pro Ala Arg Glu Val Leu Glu Phe Leu Ser Lys Leu
580 585 590
Ser Ser Ile Ile Pro Ser Ala Phe Pro Ser Trp Tyr Met Asp Ala Leu
595 600 605
Lys Asp Met Glu Asp Arg Ala Gln Ala Ile Ile Asp Thr Thr Asp Asp
610 615 620
Ala Thr Ala Met Ala Ser Ala Ser Pro Ser Val Met Ser Thr Asn Phe
625 630 635 640
Cys Pro Glu
<210>170
<211>902
<212>PRT
<213>人
<400>170
Met Gly Ala Ala Ser Cys Glu Asp Glu Glu Leu Glu Phe Lys Leu Val
1 5 10 15
Phe Gly Glu Glu Lys Glu Ala Pro Pro Leu Gly Ala Gly Gly Leu Gly
20 25 30
Glu Glu Leu Asp Ser Glu Asp Ala Pro Pro Cys Cys Arg Leu Ala Leu
35 40 45
Gly Glu Pro Pro Pro Tyr Gly Ala Ala Pro Ile Gly Ile Pro Arg Pro
50 55 60
Pro Pro Pro Arg Pro Gly Met His Ser Pro Pro Pro Arg Pro Ala Pro
65 70 75 80
Ser Pro Gly Thr Trp Glu Ser Gln Pro Ala Arg Ser Val Arg Leu Gly
85 90 95
Gly Pro Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly Arg Val Leu Glu
100 105 110
Cys Pro Ser Ile Arg Ile Thr Ser Ile Ser Pro Thr Pro Glu Pro Pro
115 120 125
Ala Ala Leu Glu Asp Asn Pro Asp Ala Trp Gly Asp Gly Ser Pro Arg
130 135 140
Asp Tyr Pro Pro Pro Glu Gly Phe Gly Gly Tyr Arg Glu Ala Gly Ala
145 150 155 160
Gln Gly Gly Gly Ala Phe Phe Ser Pro Ser Pro Gly Ser Ser Ser Leu
165 170 175
Ser Ser Trp Ser Phe Phe Ser Asp Ala Ser Asp Glu Ala Ala Leu Tyr
180 185 190
Ala Ala Cys Asp Glu Val Glu Ser Glu Leu Asn Glu Ala Ala Ser Arg
195 200 205
Phe Gly Leu Gly Ser Pro Leu Pro Ser Pro Arg Ala Ser Pro Arg Pro
210 215 220
Trp Thr Pro Glu Asp Pro Trp Ser Leu Tyr Gly Pro Ser Pro Gly Gly
225 230 235 240
Arg Gly Pro Glu Asp Ser Trp Leu Leu Leu Ser Ala Pro Gly Pro Thr
245 250 255
Pro Ala Ser Pro Arg Pro Ala Ser Pro Cys Gly Lys Arg Arg Tyr Ser
260 265 270
Ser Ser Gly Thr Pro Ser Ser Ala Ser Pro Ala Leu Ser Arg Arg Gly
275 280 285
Ser Leu Gly Glu Glu Gly Ser Glu Pro Pro Pro Pro Pro Pro Leu Pro
290 295 300
Leu Ala Arg Asp Pro Gly Ser Pro Gly Pro Phe Asp Tyr Val Gly Ala
305 310 315 320
Pro Pro Ala Glu Ser Ile Pro Gln Lys Thr Arg Arg Thr Ser Ser Glu
325 330 335
Gln Ala Val Ala Leu Pro Arg Ser Glu Glu Pro Ala Ser Cys Asn Gly
340 345 350
Lys Leu Pro Leu Gly Ala Glu Glu Ser Val Ala Pro Pro Gly Gly Ser
355 360 365
Arg Lys Glu Val Ala Gly Met Asp Tyr Leu Ala Val Pro Ser Pro Leu
370 375 380
Ala Trp ser Lys Ala Arg Ile Gly Gly His Ser Pro Ile Phe Arg Thr
385 390 395 400
Ser Ala Leu Pro Pro Leu Asp Trp Pro Leu Pro Ser Gln Tyr Glu Gln
405 410 415
Leu Glu Leu Arg Ile Glu Val Gln Pro Arg Ala His His Arg Ala His
420 425 430
Tyr Glu Thr Glu Gly Ser Arg Gly Ala Val Lys Ala Ala Pro Gly Gly
435 440 445
His Pro Val Val Lys Leu Leu Gly Tyr Ser Glu Lys Pro Leu Thr Leu
450 455 460
Gln Met Phe Ile Gly Thr Ala Asp Glu Arg Asn Leu Arg Pro His Ala
465 470 475 480
Phe Tyr Gln Val His Arg Ile Thr Gly Lys Met Val Ala Thr Ala Ser
485 490 495
Tyr Glu Ala Val Val Ser Gly Thr Lys Val Leu Glu Met Thr Leu Leu
500 505 510
Pro Glu Asn Asn Met Ala Ala Asn Ile Asp Cys Ala Gly Ile Leu Lys
515 520 525
Leu Arg Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly
530 535 540
Arg Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val His Val Pro Gln
545 550 555 560
Gly Gly Gly Lys Val Val Ser Val Gln Ala Ala Ser Val Pro Ile Glu
565 570 575
Cys Ser Gln Arg Ser Ala Gln Glu Leu Pro Gln Val Glu Ala Tyr Ser
580 585 590
Pro Ser Ala Cys Ser Val Arg Gly Gly Glu Glu Leu Val Leu Thr Gly
595 600 605
Ser Asn Phe Leu Pro Asp Ser Lys Val Val Phe Ile Glu Arg Gly Pro
610 615 620
Asp Gly Lys Leu Gln Trp Glu Glu Glu Ala Thr Val Asn Arg Leu Gln
625 630 635 640
Ser Asn Glu Val Thr Leu Thr Leu Thr Val Pro Glu Tyr Ser Asn Lys
645 650 655
Arg Val Ser Arg Pro Val Gln Val Tyr Phe Tyr Val Ser Asn Gly Arg
660 665 670
Arg Lys Arg Ser Pro Thr Gln Ser Phe Arg Phe Leu Pro Val Ile Cys
675 680 685
Lys Glu Glu Pro Leu Pro Asp Ser Ser Leu Arg Gly Phe Pro Ser Ala
690 695 700
Ser Ala Thr Pro Phe Gly Thr Asp Met Asp Phe Ser Pro Pro Arg Pro
705 710 715 720
Pro Tyr Pro Ser Tyr Pro His Glu Asp Pro Ala Cys Glu Thr Pro Tyr
725 730 735
Leu Ser Glu Gly Phe Gly Tyr Gly Met Pro Pro Leu Tyr Pro Gln Thr
740 745 750
Gly Pro Pro Pro Ser Tyr Arg Pro Gly Leu Arg Met Phe Pro Glu Thr
755 760 765
Arg Gly Thr Thr Gly Cys Ala Gln Pro Pro Ala Val Ser Phe Leu Pro
770 775 780
Arg Pro Phe Pro Ser Asp Pro Tyr Gly Gly Arg Gly Ser Ser Phe Pro
785 790 795 800
Leu Gly Leu Pro Phe Ser Pro Pro Ala Pro Phe Arg Pro Pro Pro Leu
805 810 815
Pro Ala Ser Pro Pro Leu Glu Gly Pro Phe Pro Ser Gln Ser Asp Val
820 825 830
His Pro Leu Pro Ala Glu Gly Tyr Asn Lys Val Gly Pro Gly Tyr Gly
835 840 845
Pro Gly Glu Gly Ala Pro Glu Gln Glu Lys Ser Arg Gly Gly Tyr Ser
850 855 860
Ser Gly Phe Arg Asp Ser Val Pro Ile Gln Gly Ile Thr Leu Glu Glu
865 870 875 880
Val Ser Glu Ile Ile Gly Arg Asp Leu Ser Gly Phe Pro Ala Pro Pro
885 890 895
Gly Glu Glu Pro Pro Ala
900
<210>171
<211>478
<212>PRT
<213>人
<400>171
Met Ser Pro Pro Leu Leu Lys Leu Gly Ala Val Leu Ser Thr Met Ala
1 5 10 15
Met Ile Ser Asn Trp Met Ser Gln Thr Leu Pro Ser Leu Val Gly Leu
20 25 30
Asn Thr Thr Arg Leu Ser Thr Pro Asp Thr Leu Thr Gln Ile Ser Pro
35 40 45
Lys Glu Gly Trp Gln Val Tyr Ser Ser Ala Gln Asp Pro Asp Gly Arg
50 55 60
Cys Ile Cys Thr Val Val Ala Pro Glu Gln Asn Leu Cys Ser Arg Asp
65 70 75 80
Ala Lys Ser Arg Gln Leu Arg Gln Leu Leu Glu Lys Val Gln Asn Met
85 90 95
Ser Gln Ser Ile Glu Val Leu Asn Leu Arg Thr Gln Arg Asp Phe Gln
100 105 110
Tyr Val Leu Lys Met Glu Thr Gln Met Lys Gly Leu Lys Ala Lys Phe
115 120 125
Arg Gln Ile Glu Asp Asp Arg Lys Thr Leu Met Thr Lys His Phe Gln
130 135 140
Glu Leu Lys Glu Lys Met Asp Glu Leu Leu Pro Leu Ile Pro Val Leu
145 150 155 160
Glu Gln Tyr Lys Thr Asp Ala Lys Leu Ile Thr Gln Phe Lys Glu Glu
165 170 175
Ile Arg Asn Leu Ser Ala Val Leu Thr Gly Ile Gln Glu Glu Ile Gly
180 185 190
Ala Tyr Asp Tyr Glu Glu Leu His Gln Arg Val Leu Ser Leu Glu Thr
195 200 205
Arg Leu Arg Asp Cys Met Lys Lys Leu Thr Cys Gly Lys Leu Met Lys
210 215 220
Ile Thr Gly Pro Val Thr Val Lys Thr Ser Gly Thr Arg Phe Gly Ala
225 230 235 240
Trp Met Thr Asp Pro Leu Ala Ser Glu Lys Asn Asn Arg Val Trp Tyr
245 250 255
Met Asp Ser Tyr Thr Asn Asn Lys Ile Val Arg Glu Tyr Lys Ser Ile
260 265 270
Ala Asp Phe Val Ser Gly Ala Glu Ser Arg Thr Tyr Asn Leu Pro Phe
275 280 285
Lys Trp Ala Gly Thr Asn His Val Val Tyr Asn Gly Ser Leu Tyr Phe
290 295 300
Asn Lys Tyr Gln Ser Asn Ile Ile Ile Lys Tyr Ser Phe Asp Met Gly
305 310 315 320
Arg Val Leu Ala Gln Arg Ser Leu Glu Tyr Ala Gly Phe His Asn Val
325 330 335
Tyr Pro Tyr Thr Trp Gly Gly Phe Ser Asp Ile Asp Leu Met Ala Asp
340 345 350
Glu Ile Gly Leu Trp Ala Val Tyr Ala Thr Asn Gln Asn Ala Gly Asn
355 360 365
Ile Val Ile Ser Gln Leu Asn Gln Asp Thr Leu Glu Val Met Lys Ser
370 375 380
Trp Ser Thr Gly Tyr Pro Lys Arg Ser Ala Gly Glu Ser Phe Met Ile
385 390 395 400
Cys Gly Thr Leu Tyr Val Thr Asn Ser His Leu Thr Gly Ala Lys Val
405 410 415
Tyr Tyr Ser Tyr Ser Thr Lys Thr Ser Thr Tyr Glu Tyr Thr Asp Ile
420 425 430
Pro Phe His Asn Gln Tyr Phe His Ile Ser Met Leu Asp Tyr Asn Ala
435 440 445
Arg Asp Arg Ala Leu Tyr Ala Trp Asn Asn Gly His Gln Val Leu Phe
450 455 460
Asn Val Thr Leu Phe His Ile Ile Lys Thr Glu Asp Asp Thr
465 470 475
<210>172
<211>316
<212>PRT
<213>人
<400>172
Met Ala Glu Val Lys Val Lys Val Gln Pro Pro Asp Ala Asp Pro Val
1 5 10 15
Glu Ile Glu Asn Arg Ile Ile Glu Leu Cys His Gln Phe Pro His Gly
20 25 30
Ile Thr Asp Gln Val Ile Gln Asn Glu Met Pro His Ile Glu Ala Gln
35 40 45
Gln Arg Ala Val Ala Ile Asn Arg Leu Leu Ser Met Gly Gln Leu Asp
50 55 60
Leu Leu Arg Ser Asn Thr Gly Leu Leu Tyr Arg Ile Lys Asp Ser Gln
65 70 75 80
Asn Ala Gly Lys Met Lys Gly Ser Asp Asn Gln Glu Lys Leu Val Tyr
85 90 95
Gln Ile Ile Glu Asp Ala Gly Asn Lys Gly Ile Trp Ser Arg Asp Ile
100 105 110
Arg Tyr Lys Ser Asn Leu Pro Leu Thr Glu Ile Asn Lys Ile Leu Lys
115 120 125
Asn Leu Glu Ser Lys Lys Leu Ile Lys Ala Val Lys Ser Val Ala Ala
130 135 140
Ser Lys Lys Lys Val Tyr Met Leu Tyr Asn Leu Gln Pro Asp Arg Ser
145 150 155 160
Val Thr Gly Gly Ala Trp Tyr Ser Asp Gln Asp Phe Glu Ser Glu Phe
165 170 175
Val Glu Val Leu Asn Gln Gln Cys Phe Lys Phe Leu Gln Ser Lys Ala
180 185 190
Glu Thr Ala Arg Glu Ser Lys Gln Asn Pro Met Ile Gln Arg Asn Ser
195 200 205
Ser Phe Ala Ser Ser His Glu Val Trp Lys Tyr Ile Cys Glu Leu Gly
210 215 220
Ile Ser Lys Val Glu Leu Ser Met Glu Asp Ile Glu Thr Ile Leu Asn
225 230 235 240
Thr Leu Ile Tyr Asp Gly Lys Val Glu Met Thr Ile Ile Ala Ala Lys
245 250 255
Glu Gly Thr Val Gly Ser Val Asp Gly His Met Lys Leu Tyr Arg Ala
260 265 270
Val Asn Pro Ile Ile Pro Pro Thr Gly Leu Val Arg Ala Pro Cys Gly
275 280 285
Leu Cys Pro Val Phe Asp Asp Cys His Glu Gly Gly GluIle Ser Pro
290 295 300
Ser Asn Cys Ile Tyr Met Thr Glu Trp Leu Glu Phe
305 310 315
<210>173
<211>524
<212>PRT
<213>人
<400>173
Met Ala Ala Pro Glu Pro Ala Arg Ala Ala Pro Pro Pro Pro Pro Pro
1 5 10 15
Pro Pro Pro Pro Pro Gly Ala Asp Arg Val Val Lys Ala Val Pro Phe
20 25 30
Pro Pro Thr His Arg Leu Thr Ser Glu Glu Val Phe Asp Leu Asp Gly
35 40 45
Ile Pro Arg Val Asp Val Leu Lys Asn His Leu Val Lys Glu Gly Arg
50 55 60
Val Asp Glu Glu Ile Ala Leu Arg Ile Ile Asn Glu Gly Ala Ala Ile
65 70 75 80
Leu Arg Arg Glu Lys Thr Met Ile Glu Val Glu Ala Pro Ile Thr Val
85 90 95
Cys Gly Asp Ile His Gly Gln Phe Phe Asp Leu Met Lys Leu Phe Glu
100 105 110
Val Gly Gly Ser Pro Ala Asn Thr Arg Tyr Leu Phe Leu Gly Asp Tyr
115 120 125
Val Asp Arg Gly Tyr Phe Ser Ile Glu Cys Val Leu Tyr Leu Trp Val
130 135 140
Leu Lys Ile Leu Tyr Pro Ser Thr Leu Phe Leu Leu Arg Gly Asn His
145 150 155 160
Glu Cys Arg His Leu Thr Glu Tyr Phe Thr Phe Lys Gln Glu Cys Lys
165 170 175
Ile Lys Tyr Ser Glu Arg Val Tyr Glu Ala Cys Met Glu Ala Phe Asp
180 185 190
Ser Leu Pro Leu Ala Ala Leu Leu Asn Gln Gln Phe Leu Cys Val His
195 200 205
Gly Gly Leu Ser Pro Glu Ile His Thr Leu Asp Asp Ile Arg Arg Leu
210 215 220
Asp Arg Phe Lys Glu Pro Pro Ala Phe Gly Pro Met Cys Asp Leu Leu
225 230 235 240
Trp Ser Asp Pro Ser Glu Asp Phe Gly Asn Glu Lys Ser Gln Glu His
245 250 255
Phe Ser His Asn Thr Val Arg Gly Cys Ser Tyr Phe Tyr Asn Tyr Pro
260 265 270
Ala Val Cys Glu Phe Leu Gln Asn Asn Asn Leu Leu Ser Ile Ile Arg
275 280 285
Ala His Glu Ala Gln Asp Ala Gly Tyr Arg Met Tyr Arg Lys Ser Gln
290 295 300
Thr Thr Gly Phe Pro Ser Leu Ile Thr Ile Phe Ser Ala Pro Asn Tyr
305 310 315 320
Leu Asp Val Tyr Asn Asn Lys Ala Ala Val Leu Lys Tyr Glu Asn Asn
325 330 335
Val Met Asn Ile Arg Gln Phe Asn Cys Ser Pro His Pro Tyr Trp Leu
340 345 350
Pro Asn Phe Met Asp Val Phe Thr Trp Ser Leu Pro Phe Val Gly Glu
355 360 365
Lys Val Thr Glu Met Leu Val Asn Val Leu Ser Ile Cys Ser Asp Asp
370 375 380
Glu Leu Met Thr Glu Gly Glu Asp Gln Phe Asp Gly Ser Ala Ala Ala
385 390 395 400
Ara Lys Glu Ile Ile Arg Asn Lys Ile Arg Ala Ile Gly Lys Met Ala
405 410 415
Arg Val Phe Ser Val Leu Arg Glu Glu Ser Glu Ser Val Leu Thr Leu
420 425 430
Lys Gly Leu Thr Pro Thr Gly Met Leu Pro Ser Gly Val Leu Ala Gly
435 440 445
Gly Arg Gln Thr Leu Gln Ser Ala Thr Val Glu Ala Ile Glu Ala Glu
450 455 460
Lys Ala Ile Arg Gly Phe Ser Pro Pro His Arg Ile Cys Ser Phe Glu
465 470 475 480
Glu Ala Lys Gly Leu Asp Arg Ile Asn Glu Arg Met Pro Pro Arg Lys
485 490 495
Asp Ala Val Gln Gln Asp Gly Phe Asn Ser Leu Asn Thr Ala His Ala
500 505 510
Thr Glu Asn His Gly Thr Gly Asn His Thr Ala Gln
515 520
<210>174
<211>639
<212>PRT
<213>人
<400>174
Met Ala Thr Gly Ala Asn Ala Thr Pro Leu Asp Phe Pro Ser Lys Lys
1 5 10 15
Arg Lys Arg Ser Arg Trp Asn Gln Asp Thr Met Glu Gln Lys Thr Val
20 25 30
Ile Pro Gly Met Pro Thr Val Ile Pro Pro Gly Leu Thr Arg Glu Gln
35 40 45
Glu Arg Ala Tyr Ile Val Gln Leu Gln Ile Glu Asp Leu Thr Arg Lys
50 55 60
Leu Arg Thr Gly Asp Leu Gly Ile Pro Pro Asn Pro Glu Asp Arg Ser
65 70 75 80
Pro Ser Pro Glu Pro Ile Tyr Asn Ser Glu Gly Lys Arg Leu Asn Thr
85 90 95
Arg Glu Phe Arg Thr Arg Lys Lys Leu Glu Glu Glu Arg His Asn Leu
100 105 110
Ile Thr Glu Met Val Ala Leu Asn Pro Asp Phe Lys Pro Pro Ala Asp
115 120 125
Tyr Lys Pro Pro Ala Thr Arg Val Ser Asp Lys Val Met Ile Pro Gln
150 135 140
Asp Glu Tyr Pro Glu Ile Asn Phe Val Gly Leu Leu Ile Gly Pro Arg
145 150 155 160
Gly Asn Thr Leu Lys Asn Ile Glu Lys Glu Cys Asn Ala Lys Ile Met
165 170 175
Ile Arg Gly Lys Gly Ser Val Lys Glu Gly Lys Val Gly Arg Lys Asp
180 185 190
Gly Gln Met Leu Pro Gly Glu Asp Glu Pro Leu His Ala Leu Val Thr
195 200 205
Ala Asn Thr Met Glu Asn Val Lys Lys Ala Val Glu Gln Ile Arg Asn
210 215 220
Ile Leu Lys Gln Gly Ile Glu Thr Pro Glu Asp Gln Asn Asp Leu Arg
225 230 235 240
Lys Met Gln Leu Arg Glu Leu Ala Arg Leu Asn Gly Thr Leu Arg Glu
245 250 255
Asp Asp Asn Arg Ile Leu Arg Pro Trp Gln Ser Ser Glu Thr Arg Ser
260 265 270
Ile Thr Asn Thr Thr Val Cys Thr Lys Cys Gly Gly Ala Gly His Ile
275 280 285
Ala Ser Asp Cys Lys Phe Gln Arg Pro Gly Asp Pro Gln Ser Ala Gln
290 295 300
Asp Lys Ala Arg Met Asp Lys Glu Tyr Leu Ser Leu Met Ala Glu Leu
305 310 315 320
Gly Glu Ala Pro Val Pro Ala Ser Val Gly Ser Thr Ser Gly Pro Ala
325 330 335
Thr Thr Pro Leu Ala Ser Ala Pro Arg Pro Ala Ala Pro Ala Asn Asn
340 345 350
Pro Pro Pro Pro Ser Leu Met Ser Thr Thr Gln Ser Arg Pro Pro Trp
355 360 365
Met Asn Ser Gly Pro Ser Glu Ser Arg Pro Tyr His Gly Met His Gly
370 375 380
Gly Gly Pro Gly Gly Pro Gly Gly Gly Pro His Ser Phe Pro His Pro
385 390 395 400
Leu Pro Ser Leu Thr Gly Gly His Gly Gly His Pro Met Gln His Asn
405 410 415
Pro Asn Gly Pro Pro Pro Pro Trp Met Gln Pro Pro Pro Pro Pro Met
420 425 430
Asn Gln Gly Pro His Pro Pro Gly His His Gly Pro Pro Pro Met Asp
435 440 445
Gln Tyr Leu Gly Ser Thr Pro Val Gly Ser Gly Val Tyr Arg Leu His
450 455 460
Gln Gly Lys Gly Met Met Pro Pro Pro Pro Met Gly Met Met Pro Pro
465 470 475 480
Pro Pro Pro Pro Pro Ser Gly Gln Pro Pro Pro Pro Pro Ser Gly Pro
485 490 495
Leu Pro Pro Trp Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro
500 505 510
Pro Ser Ser Ser Met Ala Ser Ser Thr Pro Leu Pro Trp Gln Gln Asn
515 520 525
Thr Thr Thr Thr Thr Thr Ser Ala Gly Thr Gly Ser Ile Pro Pro Trp
530 535 540
Gln Gln Gln Gln Ala Ala Ala Ala Ala Ser Pro Gly Ala Pro Gln Met
545 550 555 560
Gln Gly Asn Pro Thr Met Val Pro Leu Pro Pro Gly Val Gln Pro Pro
565 570 575
Leu Pro Pro Gly Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Ser
580 585 590
Ala Gly Met Met Tyr Ala Pro Pro Pro Pro Pro Pro Pro Pro Met Asp
595 600 605
Pro Ser Asn Phe Val Thr Met Met Gly Met Gly Val Ala Gly Met Pro
610 615 620
Pro Phe Gly Met Pro Pro Ala Pro Pro Pro Pro Pro Pro Gln Asn
625 630 635
<210>175
<211>661
<212>PRT
<213>人
<400>175
Met Asp Leu Gln Gln Ser Thr Thr Ile Thr Ser Leu Glu Lys Trp Cys
1 5 10 15
Leu Asp Glu Ser Leu Ser Gly Cys Arg Arg His Tyr Ser Val Lys Lys
20 25 30
Lys Leu Lys Leu Ile Arg Val Leu Gly Leu Phe Met Gly Leu Val Ala
35 40 45
Ile Ser Thr Val Ser Phe Ser Ile Ser Ala Phe Ser Glu Thr Asp Thr
50 55 60
Gln Ser Thr Gly Glu Ala Ser Val Val Ser Gly Pro Arg Val Ala Gln
65 70 75 80
Gly Tyr His Gln Arg Thr Leu Leu Asp Leu Asn Asp Lys Ile Leu Asp
85 90 95
Tyr Thr Pro Gln Pro Pro Leu Ser Lys Glu Gly Glu Ser Glu Asn Ser
100 105 110
Thr Asp His Ala Gln Gly Asp Tyr Pro Lys Asp Ile Phe Ser Leu Glu
115 120 125
Glu Arg Arg Lys Gly Ala Ile Ile Leu His Val Ile Gly Met Ile Tyr
130 135 140
Met Phe Ile Ala Leu Ala Ile Val Cys Asp Glu Phe Phe Val Pro Ser
145 150 155 160
Leu Thr Val Ile Thr Glu Lys Leu Gly Ile Ser Asp Asp Val Ala Gly
165 170 175
Ala Thr Phe Met Ala Ala Gly Gly Ser Ala Pro Glu Leu Phe Thr Ser
180 185 190
Leu Ile Gly Val Phe Ile Ala His Ser Asn Val Gly Ile Gly Thr Ile
195 200 205
Val Gly Ser Ala Val Phe Asn Ile Leu Phe Val Ile Gly Met Cys Ala
210 215 220
Leu Phe Ser Arg Glu Ile Leu Asn Leu Thr Trp Trp Pro Leu Phe Arg
225 230 235 240
Asp Val Ser Phe Tyr Ile Val Asp Leu Ile Met Leu Ile Ile Phe Phe
245 250 255
Leu Asp Asn Val Ile Met Trp Trp Glu Ser Leu Leu Leu Leu Thr Ala
260 265 270
Tyr Phe Cys Tyr Val Val Phe Met Lys Phe Asn Val Gln Val Glu Lys
275 280 285
Trp Val Lys Gln Met Ile Asn Arg Asn Lys Val Val Lys Val Thr Ala
290 295 300
Pro Glu Ala Gln Ala Lys Pro Ser Ala Ala Arg Asp Lys Asp Glu Pro
305 310 315 320
Thr Leu Pro Ala Lys Pro Arg Leu Gln Arg Gly Gly Ser Ser Ala Ser
325 330 335
Leu His Asn Ser Leu Met Arg Asn Ser Ile Phe Gln Leu Met Ile His
340 345 350
Thr Leu Asp Pro Leu Ala Glu Glu Leu Gly Ser Tyr Gly Lys Leu Lys
355 360 365
Tyr Tyr Asp Thr Met Thr Glu Glu Gly Arg Phe Arg Glu Lys Ala Ser
370 375 380
Ile Leu His Lys Ile Ala Lys Lys Lys Cys His Val Asp Glu Asn Glu
385 390 395 400
Arg Gln Asn Gly Ala Ala Asn His Val Glu Lys Ile Glu Leu Pro Asn
405 410 415
Ser Thr Ser Thr Asp Val Glu Met Thr Pro Ser Ser Asp Ala Ser Glu
420 425 430
Pro Val Gln Asn Gly Asn Leu Ser His Asn Ile Glu Gly Ala Glu Ala
435 440 445
Gln Thr Ala Asp Glu Glu Glu Asp Gln Pro Leu Ser Leu Ala Trp Pro
450 455 460
Ser Glu Thr Arg Lys Gln Val Thr Phe Leu Ile Val Phe Pro Ile Val
465 470 475 480
Phe Pro Leu Trp Ile Thr Leu Pro Asp Val Arg Lys Pro Ser Ser Arg
485 490 495
Lys Phe Phe Pro Ile Thr Phe Phe Gly Ser Ile Thr Trp Ile Ala Val
500 505 510
Phe Ser Tyr Leu Met Val Trp Trp Ala His Gln Val Gly Glu Thr Ile
515 520 525
Gly Ile Ser Glu Glu Ile Met Gly Leu Thr Ile Leu Ala Ala Gly Thr
530 535 540
Ser Ile Pro Asp Leu Ile Thr Ser Val Ile Val Ala Arg Lys Gly Leu
545 550 555 560
Gly Asp Met Ala Val Ser Ser Ser Val Gly Ser Asn Ile Phe Asp Ile
565 570 575
Thr Val Gly Leu Pro Leu Pro Trp Leu Leu Tyr Thr Val Ile His Arg
580 585 590
Phe Gln Pro Val Ala Val Ser Ser Asn Gly Leu Phe Cys Ala Ile Val
595 600 605
Leu Leu Phe Ile Met Leu Leu Phe Val Ile Leu Ser Ile Ala Leu Cys
610 615 620
Lys Trp Arg Met Asn Lys Ile Leu Gly Phe Ile Met Phe Gly Leu Tyr
625 630 635 640
Phe Val Phe Leu Val Val Ser Val Leu Leu Glu Asp Arg Ile Leu Thr
645 650 655
Lys Pro Val Ser Ile
660
<210>176
<211>780
<212>PRT
<213>人
<400>176
Met Ala Ala Pro Gly Gly Arg Ser Glu Pro Pro Gln Leu Pro Glu Tyr
1 5 10 15
Ser Cys Ser Tyr Met Val Ser Arg Pro Val Tyr Ser Glu Leu Ala Phe
20 25 30
Gln Gln Gln His Glu Arg Arg Leu Gln Glu Arg Lys Thr Leu Arg Glu
35 40 45
Ser Leu Ala Lys Cys Cys Ser Cys Ser Arg Lys Arg Ala Phe Gly Val
50 55 60
Leu Lys Thr Leu Val Pro Ile Leu Glu Trp Leu Pro Lys Tyr Arg Val
65 70 75 80
Lys Glu Trp Leu Leu Ser Asp Val Ile Ser Gly Val Ser Thr Gly Leu
85 90 95
Val Ala Thr Leu Gln Gly Met Ala Tyr Ala Leu Leu Ala Ala Val Pro
100 105 110
Val Gly Tyr Gly Leu Tyr Ser Ala Phe Phe Pro Ile Leu Thr Tyr Phe
115 120 125
Ile Phe Gly Thr Ser Arg Hi s Ile Ser Val Gly Pro Phe Pro Val Val
130 135 140
Ser Leu Met Val Gly Ser Val Val Leu Ser Met Ala Pro Asp Glu His
145 150 155 160
Phe Leu Val Ser Ser Ser Asn Gly Thr Val Leu Asn Thr Thr Met Ile
165 170 175
Asp Thr Ala Ala Arg Asp Thr Ala Arg Val Leu Ile Ala Ser Ala Leu
180 185 190
Thr Leu Leu Val Gly Ile Ile Gln LeuIle Phe Gly Gly Leu Gln Ile
195 200 205
Gly Phe Ile Val Arg Tyr Leu Ala Asp Pro Leu Val Gly Gly Phe Thr
210 215 220
Thr Ala Ala Ala Phe Gln Val Leu Val Ser Gln Leu Lys Ile Val Leu
225 230 235 240
Asn Val Ser Thr Lys Asn Tyr Asn Gly Val Leu Ser Ile Ile Tyr Thr
245 250 255
Leu Val Glu Ile Phe Gln Asn Ile Gly Asp Thr Asn Leu Ala Asp Phe
260 265 270
Thr Ala Gly Leu Leu Thr Ile Val Val Cys Met Ala Val Lys Glu Leu
275 280 285
Asn Asp Arg Phe Arg His Lys Ile Pro Val Pro Ile Pro Ile Glu Val
290 295 300
Ile Val Thr Ile Ile Ala Thr Ala Ile Ser Tyr Gly Ala Asn Leu Glu
305 310 315 320
Lys Asn Tyr Asn Ala Gly Ile Val Lys Ser Ile Pro Arg Gly Phe Leu
325 330 335
Pro Pro Glu Leu Pro Pro Val Ser Leu Phe Ser Glu Met Leu Ala Ala
340 345 350
Ser Phe Ser Ile Ala Val Val Ala Tyr Ala Ile Ala Val Ser Val Gly
355 360 365
Lys Val Tyr Ala Thr Lys Tyr Asp Tyr Thr Ile Asp Gly Asn Gln Glu
370 375 380
Phe Ile Ala Phe Gly Ile Ser Asn Ile Phe Ser Gly Phe Phe Ser Cys
385 390 395 400
Phe Val Ala Thr Thr Ala Leu Ser Arg Thr Ala Val Gln Glu Ser Thr
405 410 415
Gly Gly Lys Thr Gln Val Ala Gly Ile Ile Ser Ala Ala Ile Val Met
420 425 430
Ile Ala Ile Leu Ala Leu Gly Lys Leu Leu Glu Pro Leu Gln Lys Ser
435 440 445
Val Leu Ala Ala Val Val Ile Ala Asn Leu Lys Gly Met Phe Met Gln
450 455 460
Leu Cys Asp Ile Pro Arg Leu Trp Arg Gln Asn Lys Ile Asp Ala Val
465 470 475 480
Ile Trp Val Phe Thr Cys Ile Val Ser Ile Ile Leu Gly Leu Asp Leu
485 490 495
Gly Leu Leu Ala Gly Leu Ile Phe Gly Leu Leu Thr Val Val Leu Arg
500 505 510
Val Gln Phe Pro Ser Trp Asn Gly Leu Gly Ser Ile Pro Ser Thr Asp
515 520 525
Ile Tyr Lys Ser Thr Lys Asn Tyr Lys Asn Ile Glu Glu Pro Gln Gly
530 535 540
Val Lys Ile Leu Arg Phe Ser Ser Pro Ile Phe Tyr Gly Asn Val Asp
545 550 555 560
Gly Phe Lys Lys Cys Ile Lys Ser Thr Val Gly Phe Asp Ala Ile Arg
565 570 575
Val Tyr Asn Lys Arg Leu Lys Ala Leu Arg Lys Ile Gln Lys Leu Ile
580 585 590
Lys Ser Gly Gln Leu Arg Ala Thr Lys Asn Gly Ile Ile Ser Asp Ala
595 600 605
Val Ser Thr Asn Asn Ala Phe Glu Pro Asp Glu Asp Ile Glu Asp Leu
610 615 620
Glu Glu Leu Asp Ile Pro Thr Lys Glu Ile Glu Ile Gln Val Asp Trp
625 630 635 640
Asn Ser Glu Leu Pro Val Lys Val Asn Val Pro Lys Val Pro Ile His
645 650 655
Ser Leu Val Leu Asp Cys Gly Ala Ile Ser Phe Leu Asp Val Val Gly
660 665 670
Val Arg Ser Leu Arg Val Ile Val Lys Glu Phe Gln Arg Ile Asp Val
675 680 685
Asn Val Tyr Phe Ala Ser Leu Gln Asp Tyr Val Ile Glu Lys Leu Glu
690 695 700
Gln Cys Gly Phe Phe Asp Asp Asn Ile Arg Lys Asp Thr Phe Phe Leu
705 710 715 720
Thr Val His Asp Ala Ile Leu Tyr Leu Gln Asn Gln Val Lys Ser Gln
725 730 735
Glu Gly Gln Gly Ser Ile Leu Glu Thr Ile Thr Leu Ile Gln Asp Cys
740 745 750
Lys Asp Thr Leu Glu Leu Ile Glu Thr Glu Leu Thr Glu Glu Glu Leu
755 760 765
Asp Val Gln Asp Glu Ala Met Arg Thr Leu Ala Ser
770 775 780
<910>177
<211>670
<212>PRT
<213>人
<400>177
Met Gly Glu Thr Glu Lys Arg Ile Glu Thr His Arg Ile Arg Cys Leu
1 5 10 15
Ser Lys Leu Lys Met Phe Leu Leu Ala Ile Thr Cys Ala Phe Val Ser
20 25 30
Lys Thr Leu Ser Gly Ser Tyr Met Asn Ser Met Leu Thr Gln Ile Glu
35 40 45
Arg Gln Phe Asn Ile Pro Thr Ser Leu Val Gly Phe Ile Asn Gly Ser
50 55 60
Phe Glu Ile Gly Asn Leu Leu Leu Ile Ile Phe Val Ser Tyr Phe Gly
65 70 75 80
Thr Lys Leu His Arg Pro Ile Met Ile Gly Ile Gly Cys Val Val Met
85 90 95
Gly Leu Gly Cys Phe Leu Lys Ser Leu Pro His Phe Leu Met Asn Gln
100 105 110
Tyr Glu Tyr Glu Ser Thr Val Ser Val Ser Gly Asn Leu Ser Ser Asn
115 120 125
Ser Phe Leu Cys Met Glu Asn Gly Thr Gln Ile Leu Arg Pro Thr Gln
130 135 140
Asp Pro Ser Glu Cys Thr Lys Glu Val Lys Ser Leu Met Trp Val Tyr
145 150 155 160
Val Leu Val Gly Asn Ile Val Arg Gly Met Gly Glu Thr Pro Ile Leu
165 170 175
Pro Leu Gly Ile Ser Tyr Ile Glu Asp Phe Ala Lys Phe Glu Asn Ser
180 185 190
Pro Leu Tyr Ile Gly Leu Val Glu Thr Gly Ala Ile Ile Gly Pro Leu
195 200 205
Ile Gly Leu Leu Leu Ala Ser Phe Cys Ala Asn Val Tyr Val Asp Thr
210 215 220
Gly Phe Val Asn Thr Asp Asp Leu Ile Ile Thr Pro Thr Asp Thr Arg
225 230 235 240
Trp Val Gly Ala Trp Trp Phe Gly Phe Leu Ile Cys Ala Gly Val Asn
245 250 255
Val Leu Thr Ala Ile Pro Phe Phe Phe Leu Pro Asn Thr Leu Pro Lys
260 265 270
Glu Gly Leu Glu Thr Asn Ala Asp Ile Ile Lys Asn Glu Asn Glu Asp
275 280 285
Lys Gln Lys Glu Glu Val Lys Lys Glu Lys Tyr Gly Ile Thr Lys Asp
290 295 300
Phe Leu Pro Phe Met Lys Ser Leu Ser Cys Asn Pro Ile Tyr Met Leu
305 310 315 320
Phe Ile Leu Val Ser Val Ile Gln Phe Asn Ala Phe Val Asn Met Ile
325 330 335
Ser Phe Met Pro Lys Tyr Leu Glu Gln Gln Tyr Gly Ile Ser Ser Ser
340 345 350
Asp Ala Ile Phe Leu Met Gly Ile Tyr Asn Leu Pro Pro Ile Cys Ile
355 360 365
Gly Tyr Ile Ile Gly Gly Leu Ile Met Lys Lys Phe Lys Ile Thr Val
370 375 380
Lys Gln Ala Ala His Ile Gly Cys Trp Leu Ser Leu Leu Glu Tyr Leu
385 390 395 400
Leu Tyr Phe Leu Ser Phe Leu Met Thr Cys Glu Asn Ser Ser Val Val
405 410 415
Gly Ile Asn Thr Ser Tyr Glu Gly Ile Pro Gln Asp Leu Tyr Val Glu
420 425 430
Asn Asp Ile Phe Ala Asp Cys Asn Val Asp Cys Asn Cys Pro Ser Lys
435 440 445
Ile Trp Asp Pro Val Cys Gly Asn Asn Gly Leu Ser Tyr Leu Ser Ala
450 455 460
Cys Leu Ala Gly Cys Glu Thr Ser Ile Gly Thr Gly Ile Asn Met Val
465 470 475 480
Phe Gln Asn Cys Ser Cys Ile Gln Thr Ser Gly Asn Ser Ser Ala Val
485 490 495
Leu Gly Leu Cys Asp Lys Gly Pro Asp Cys Ser Leu Met Leu Gln Tyr
500 505 510
Phe Leu Ile Leu Ser Ala Met Ser Ser Phe Ile Tyr Ser Leu Ala Ala
515 520 525
Ile Pro Gly Tyr Met Val Leu Leu Arg Cys Met Lys Ser Glu Glu Lys
530 535 540
Ser Leu Gly Val Gly Leu His Thr Phe Cys Thr Arg Val Phe Ala Gly
545 550 555 560
Ile Pro Ala Pro Ile Tyr Phe Gly Ala Leu Met Asp Ser Thr Cys Leu
565 570 575
His Trp Gly Thr Leu Lys Cys Gly Glu Ser Gly Ala Cys Arg Ile Tyr
580 585 590
Asp Ser Thr Thr Phe Arg Tyr Ile Tyr Leu Gly Leu Pro Ala Ala Leu
595 600 605
Arg Gly Ser Ser Phe Val Pro Ala Leu Ile Ile Leu Ile Leu Leu Arg
610 615 620
Lys Cys His Leu Pro Gly Glu Asn Ala Ser Ser Gly Thr Glu Leu Ile
625 630 635 640
Glu Thr Lys Val Lys Gly Lys Glu Asn Glu Cys Lys Asp Ile Tyr Gln
645 650 655
Lys Ser Thr Val Leu Lys Asp Asp Glu Leu Lys Thr Lys Leu
660 665 670
<210>178
<211>284
<212>PRT
<213>人
<400>178
Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu
1 5 10 15
Asn Ala Ile Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Gln Ala
20 25 30
Glu Asp Arg Cys Lys Gln Leu Glu Glu Glu Gln Gln Ala Leu Gln Lys
35 40 45
Lys Leu Lys Gly Thr Glu Asp Glu Val Glu Lys Tyr Ser Glu Ser Val
50 55 60
Lys Glu Ala Gln Glu Lys Leu Glu Gln Ala Glu Lys Lys Ala Thr Asp
65 70 75 80
Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu
85 90 95
Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys
100 105 110
Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys
115 120 125
Val Ile Glu Asn Arg Ala Met Lys Asp Glu Glu Lys Met Glu Leu Gln
130 135 140
Glu Met Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ser Asp Arg
145 150 155 160
Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Leu Glu Gly Glu Leu
165 170 175
Glu Arg Ser Glu Glu Arg Ala Glu Val Ala Glu Ser Lys Cys Gly Asp
180 185 190
Leu Glu Glu Glu Leu Lys Ile Val Thr Asn Asn Leu Lys Ser Leu Glu
195 200 205
Ala Gln Ala Asp Lys Tyr Ser Thr Lys Glu Asp Lys Tyr Glu Glu Glu
210 215 220
Ile Lys Leu Leu Glu Glu Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu
225 230 235 240
Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu
245 250 255
Glu Asp Glu Val Tyr Ala Gln Lys Met Lys Tyr Lys Ala Ile Ser Glu
260 265 270
Glu Leu Asp Asn Ala Leu Asn Asp Ile Thr Ser Leu
275 280
<210>179
<211>329
<212>PRT
<213>人
<400>179
Met Thr Gly Asn Ala Gly Glu Trp Cys Leu Met Glu Ser Asp Pro Gly
1 5 10 15
Val Phe Thr Glu Leu Ile Lys Gly Phe Gly Cys Arg Gly Ala Gln Val
20 25 30
Glu Glu Ile Trp Ser Leu Glu Pro Glu Asn Phe Glu Lys Leu Lys Pro
35 40 45
Val His Gly Leu Ile Phe Leu Phe Lys Trp Gln Pro Gly Glu Glu Pro
50 55 60
Ala Gly Ser Val Val Gln Asp Ser Arg Leu Asp Thr Ile Phe Phe Ala
65 70 75 80
Lys Gln Val Ile Asn Asn Ala Cys Ala Thr Gln Ala Ile Val Ser Val
85 90 95
Leu Leu Asn Cys Thr His Gln Asp Val His Leu Gly Glu Thr Leu Ser
100 105 110
Glu Phe Lys Glu Phe Ser Gln Ser Phe Asp Ala Ala Met Lys Gly Leu
115 120 125
Ala Leu Ser Asn Ser Asp Val Ile Arg Gln Val His Asn Ser Phe Ala
130 135 140
Arg Gln Gln Met Phe Glu Phe Asp Thr Lys Thr Ser Ala Lys Glu Glu
145 150 155 160
Asp Ala Phe His Phe Val Ser Tyr Val Pro Val Asn Gly Arg Leu Tyr
165 170 175
Glu Leu Asp Gly Leu Arg Glu Gly Pro Ile Asp Leu Gly Ala Gys Asn
180 185 190
Gln Asp Asp Trp Phe Ser Ala Val Arg Pro Val Ile Glu Lys Arg Ile
195 200 205
Gln Lys Tyr Ser Glu Gly Glu Ile Arg Phe Asn Leu Met Ala Ile Val
210 215 220
Ser Asp Arg Lys Met Ile Tyr Glu Gln Lys Ile Ala Glu Leu Gln Arg
225 230 235 240
Gln Leu Ala Glu Glu Glu Pro Met Asp Thr Asp Gln Gly Asn Ser Met
245 250 255
Leu Ser Ala Ile Gln Ser Glu Val Ala Lys Asn Gln Met Leu Ile Glu
260 265 270
Glu Glu Val Gln Lys Leu Lys Arg Tyr Lys Ile Glu Asn Ile Arg Arg
275 280 285
Lys His Asn Tyr Leu Pro Phe Ile Met Glu Leu Leu Lys Thr Leu Ala
290 295 300
Glu His Gln Gln Leu Ile Pro Leu Val Glu Lys Ala Lys Glu Lys Gln
305 310 315 320
Asn Ala Lys Lys Ala Gln Glu Thr Lys
325
<210>180
<211>54l
<212>PRT
<213>人
<400>180
Met Lys Ser Tyr Thr Pro Tyr Phe Ile Leu Leu Trp Ser Ala Val Gly
1 5 10 15
Ile Ala Lys Ala Ala Lys Ile Ile Ile Val Pro Pro Ile Met Phe Glu
20 25 30
Ser His Met Tyr Ile Phe Lys Thr Leu Ala Ser Ala Leu His Glu Arg
35 40 45
Gly His His Thr Val Phe Leu Leu Ser Glu Gly Arg Asp Ile Ala Pro
50 55 60
Ser Asn His Tyr Ser Leu Gln Arg Tyr Pro Gly Ile Phe Asn Ser Thr
65 70 75 80
Thr Ser Asp Ala Phe Leu Gln Ser Lys Met Arg Asn Ile Phe Ser Gly
85 90 95
Arg Leu Thr Ala Ile Glu Leu Phe Asp Ile Leu Asp His Tyr Thr Lys
100 105 110
Asn Cys Asp Leu Met Val Gly Asn His Ala Leu Ile Gln Gly Leu Lys
115 120 125
Lys Glu Lys Phe Asp Leu Leu Leu Val Asp Pro Asn Asp Met Cys Gly
130 135 140
Phe Val Ile Ala His Leu Leu Gly Val Lys Tyr Ala Val Phe Ser Thr
145 150 155 160
Gly Leu Trp Tyr Pro Ala Glu Val Gly Ala Pro Ala Pro Leu Ala Tyr
165 170 175
Val Pro Glu Phe Asn Ser Leu Leu Thr Asp Arg Met Asn Leu Leu Gln
180 185 190
Arg Met Lys Asn Thr Gly Val Tyr Leu Ile Ser Arg Leu Gly Val Ser
195 200 205
Phe Leu Val Leu Pro Lys Tyr Glu Arg Ile Met Gln Lys Tyr Asn Leu
210 215 220
Leu Pro Glu Lys Ser Met Tyr Asp Leu Val His Gly Ser Ser Leu Trp
225 230 235 240
Met Leu Cys Thr Asp Val Ala Leu Glu Phe Pro Arg Pro Thr Leu Pro
245 250 255
Asn Val Val Tyr Val Gly Gly Ile Leu Thr Lys Pro Ala Ser Pro Leu
260 265 270
Pro Glu Asp Leu Gln Arg Trp Val Asn Gly Ala Asn Glu His Gly Phe
275 280 285
Val Leu Val Ser Phe Gly Ala Gly Val Lys Tyr Leu Ser Glu Asp Ile
290 295 300
Ala Asn Lys Leu Ala Gly Ala Leu Gly Arg Leu Pro Gln Lys Val Ile
305 310 315 320
Trp Arg Phe Ser Gly Pro Lys Pro Lys Asn Leu Gly Asn Asn Thr Lys
325 330 335
Leu Ile Glu Trp Leu Pro Gln Asn Asp Leu Leu Gly His Ser Lys Ile
340 345 350
Lys Ala Phe Leu Ser His Gly Gly Leu Asn Ser Ile Phe Glu Thr Met
355 360 365
Tyr His Gly Val Pro Val Val Gly Ile Pro Leu Phe Gly Asp His Tyr
370 375 380
Asp Thr Met Thr Arg Val Gln Ala Lys Gly Met Gly Ile Leu Leu Glu
385 390 395 400
Trp Lys Thr Val Thr Glu Lys Glu Leu Tyr Glu Ala Leu Val Lys Val
405 410 415
Ile Asn Asn Pro Ser Tyr Arg Gln Arg Ala Gln Lys Leu Ser Glu Ile
420 425 430
His Lys Asp Gln Pro Gly His Pro Val Asn Arg Thr Ile Tyr Trp Ile
435 440 445
Asp Tyr Ile Ile Arg His Asn Gly Ala His His Leu Arg Ala Ala Val
450 455 460
His Gln Ile Ser Phe Cys Gln Tyr Phe Leu Leu Asp Ile Ala Phe Val
465 470 475 480
Leu Leu Leu Gly Ala Ala Leu Leu Tyr Phe Leu Leu Ser Trp Val Thr
485 490 495
Lys Phe Ile Tyr Arg Lys Ile Lys Ser Leu Trp Ser Arg Asn Lys His
500 505 510
Ser Thr Val Asn Gly His Tyr His Asn Gly Ile Leu Asn Gly Lys Tyr
515 520 525
Lys Arg Asn Gly His Ile Lys His Glu Lys Lys Val Lys
530 535 540
<210>181
<211>457
<212>PRT
<213>人
<400>181
Met Ser Gln Gly Ser Val Thr Phe Arg Asp Val Ala Ile Asp Phe Ser
5 10 15
Gln Glu Glu Trp Lys Trp Leu Gln Pro Ala Gln Arg Asp Leu Tyr Arg
20 25 30
Cys Val Met Leu Glu Asn Tyr Gly His Leu Val Ser Leu Gly Leu Ser
35 40 45
Ile Ser Lys Pro Asp Val Val Ser Leu Leu Glu Gln Gly Lys Glu Pro
50 55 60
Trp Leu Gly Lys Arg Glu Val Lys Arg Asp Leu Phe Ser Val Ser Glu
65 70 75 80
Ser Ser Gly Glu Ile Lys Asp Phe Ser Pro Lys Asn Val Ile Tyr Asp
85 90 95
Asp Ser Ser Gln Tyr Leu Ile Met Glu Arg Ile Leu Ser Gln Gly Pro
100 105 110
Val Tyr Ser Ser Phe Lys Gly Gly Trp Lys Cys Lys Asp His Thr Glu
115 120 125
Met Leu Gln Glu Asn Gln Gly Cys Ile Arg Lys Val Thr Val Ser His
130 135 140
Gln Glu Ala Leu Ala Gln His Met Asn Ile Ser Thr Val Glu Arg Pro
145 150 155 160
Tyr Gly Cys His Glu Cys Gly Lys Thr Phe Gly Arg Arg Phe Ser Leu
165 170 175
Val Leu His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Ala Cys Lys
180 185 190
Glu Cys Gly Lys Thr Phe Ser Gln Ile Ser Asn Leu Val Lys His Gln
195 200 205
Met Ile His Thr Gly Lys Lys Pro His Glu Cys Lys Asp Cys Asn Lys
210 215 220
Thr Phe Ser Tyr Leu Ser Phe Leu Ile Glu His Gln Arg Thr His Thr
225 230 235 240
Gly Glu Lys Pro Tyr Glu Cys Thr Glu Cys Gly Lys Ala Phe Ser Arg
245 250 255
Ala Ser Asn Leu Thr Arg His Gln Arg Ile His Ile Gly Lys Lys Gln
260 265 270
Tyr Ile Cys Arg Lys Cys Gly Lys Ala Phe Ser Ser Gly Ser Glu Leu
275 280 285
Ile Arg His Gln Ile Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Ile
290 295 300
Glu Cys Gly Lys Ala Phe Arg Arg Phe Ser His Leu Thr Arg His Gln
305 310 315 320
Ser Ile His Thr Thr Lys Thr Pro Tyr Glu Cys Asn Glu Cys Arg Lys
325 330 335
Ala Leu Arg Cys His Ser Phe Leu Ile Lys His Gln Arg Ile His Ala
340 345 350
Gly Glu Lys Leu Tyr Glu Cys Asp Glu Cys Gly Lys Val Phe Thr Trp
355 360 365
His Ala Ser Leu Ile Gln His Thr Lys Ser His Thr Gly Glu Lys Pro
370 375 380
Tyr Ala Cys Ala Glu Cys Asp Lys Ala Phe Ser Arg Ser Phe Ser Leu
385 390 395 400
Ile Leu His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Val Cys Lys
405 410 415
Val Cys Asn Lys Ser Phe Ser Trp Ser Ser Asn Leu Ala Lys His Gln
420 425 430
Arg Thr His Thr Leu Asp Asn Pro Tyr Glu Tyr Glu Asn Ser Phe Asn
435 440 445
Tyr His Ser Phe Leu Thr Glu His Gln
450 455
<210>182
<211>653
<212>PRT
<213>人
<400>182
Met Ala Ser Arg Leu Pro Thr Ala Trp Ser Cys Glu Pro Val Thr Phe
1 5 10 15
Glu Asp Val Thr Leu Gly Phe Thr Pro Glu Glu Trp Gly Leu Leu Asp
20 25 30
Leu Lys Gln Lys Ser Leu Tyr Arg Glu Val Met Leu Glu Asn Tyr Arg
35 40 45
Asn Leu Val Ser Val Glu His Gln Leu Ser Lys Pro Asp Val Val Ser
50 55 60
Gln Leu Glu Glu Ala Glu Asp Phe Trp Pro Val Glu Arg Gly Ile Pro
65 70 75 80
Gln Asp Thr Ile Pro Glu Tyr Pro Glu Leu Gln Leu Asp Pro Lys Leu
85 90 95
Asp Pro Leu Pro Ala Glu Ser Pro Leu Met Asn Ile Glu Val Val Glu
100 105 110
Val Leu Thr Leu Asn Gln Glu Val Ala Gly Pro Arg Asn Ala Gln Ile
115 120 125
Gln Ala Leu Tyr Ala Glu Asp Gly Ser Leu Ser Ala Asp Ala Pro Ser
130 135 140
Glu Gln Ile Gln Gln Gln Gly Lys His Pro Gly Asp Pro Glu Ala Ala
145 150 155 160
Arg Gln Arg Phe Arg Gln Phe Arg Tyr Lys Asp Met Thr Gly Pro Arg
165 170 175
Glu Ala Leu Asp Gln Leu Arg Glu Leu Cys His Gln Trp Leu Gln Pro
180 185 190
Lys Ala Arg Ser Lys Glu Gln Ile Leu Glu Leu Leu Val Leu Glu Gln
195 200 205
Phe Leu Gly Ala Leu Pro Val Lys Leu Arg Thr Trp Val Glu Ser Gln
210 215 220
His Pro Glu Asn Cys Gln Glu Val Val Ala Leu Val Glu Gly Val Thr
225 230 235 240
Trp Met Ser Glu Glu Glu Val Leu Pro Ala Gly Gln Pro Ala Glu Gly
245 250 255
Thr Thr Cys Cys Leu Glu Val Thr Ala Gln Gln Glu Glu Lys Gln Glu
260 265 270
Asp Ala Ala Ile Cys Pro Val Thr Val Leu Pro Glu Glu Pro Val Thr
275 280 285
Phe Gln Asp Val Ala Val Asp Phe Ser Arg Glu Glu Trp Gly Leu Leu
290 295 300
Gly Pro Thr Gln Arg Thr Glu Tyr Arg Asp Val Met Leu Glu Thr Phe
305 310 315 320
Gly His Leu Val Ser Val Gly Trp Glu Thr Thr Leu Glu Asn Lys Glu
325 330 335
Leu Ala Pro Asn Ser Asp Ile Pro Glu Glu Glu Pro Ala Pro Ser Leu
340 345 350
Lys Val Gln Glu Ser Ser Arg Asp Cys Ala Leu Ser Ser Thr Leu Glu
355 360 365
Asp Thr Leu Gln Gly Gly Val Gln Glu Val Gln Asp Thr Val Leu Lys
370 375 380
Gln Met Glu Ser Ala Gln Glu Lys Asp Leu Pro Gln Lys Lys His Phe
385 390 395 400
Asp Asn Arg Glu Ser Gln Ala Asn Ser Gly Ala Leu Asp Thr Asn Gln
405 410 415
Val Ser Leu Gln Lys Ile Asp Asn Pro Glu Ser Gln Ala Asn Ser Gly
420 425 430
Ala Leu Asp Thr Asn Gln Val Leu Leu His Lys Ile Pro Pro Arg Lys
435 440 445
Arg Leu Arg Lys Arg Asp Ser Gln Val Lys Ser Met Lys His Asn Ser
450 455 460
Arg Val Lys Ile His Gln Lys Ser Cys Glu Arg Gln Lys Ala Lys Glu
465 470 475 480
Gly Asn Gly Cys Arg Lys Thr Phe Ser Arg Ser Thr Lys Gln Ile Thr
485 490 495
Phe Ile Arg Ile His Lys Gly Ser Gln Val Cys Arg Cys Ser Glu Cys
500 505 510
Gly Lys Ile Phe Arg Asn Pro Arg Tyr Phe Ser Val His Lys Lys Ile
515 520 525
His Thr Gly Glu Arg Pro Tyr Val Cys Gln Asp Cys Gly Lys Gly Phe
530 535 540
Val Gln Ser Ser Ser Leu Thr Gln His Gln Arg Val His Ser Gly Glu
545 550 555 560
Arg Pro Phe Glu Cys Gln Glu Cys Gly Arg Thr Phe Asn Asp Arg Ser
565 570 575
Ala Ile Ser Gln His Leu Arg Thr His Thr Gly Ala Lys Pro Tyr Lys
580 585 590
Cys Gln Asp Cys Gly Lys Ala Phe Arg Gln Ser Ser His Leu Ile Arg
595 600 605
His Gln Arg Thr His Thr Gly Glu Arg Pro Tyr Ala Cys Asn Lys Cys
610 615 620
Gly Lys Ala Phe Thr Gln Ser Ser His Leu Ile Gly His Gln Arg Thr
625 630 635 640
His Asn Arg Thr Lys Arg Lys Lys Lys Gln Pro Thr Ser
645 650
<210>183
<211>715
<212>PRT
<213>人
<400>183
Met Glu Thr Leu Glu Ser Glu Leu Thr Cys Pro Ile Cys Leu Glu Leu
1 5 10 15
Phe Glu Asp Pro Leu Leu Leu Pro Cys Ala His Ser Leu Cys Phe Ser
20 25 30
Cys Ala His Arg Ile Leu Val Ser Ser Cys Ser Ser Gly Glu Ser Ile
25 40 45
Glu Pro Ile Thr Ala Phe Gln Cys Pro Thr Cys Arg Tyr Val Ile Ser
50 55 60
Leu Asn His Arg Gly Leu Asp Gly Leu Lys Arg Asn Val Thr Leu Gln
65 70 75 80
Asn Ile Ile Asp Arg Phe Gln Lys Ala Ser Val Ser Gly Pro Asn Ser
85 90 95
Pro Ser Glu Ser Arg Arg Glu Arg Thr Tyr Arg Pro Thr Thr Ala Met
100 105 110
Ser Ser Glu Arg Ile Ala Cys Gln Phe Cys Glu Gln Asp Pro Pro Arg
115 120 125
Asp Ala Val Lys Thr Cys Ile Thr Cys Glu Val Ser Tyr Cys Asp Arg
130 135 140
Cys Leu Arg Ala Thr His Pro Asn Lys Lys Pro Phe Thr Ser His Arg
145 150 155 160
Leu Val Glu Pro Val Pro Asp Thr His Leu Arg Gly Ile Thr Cys Leu
165 170 175
Asp His Glu Asn Glu Lys Val Asn Met Tyr Cys Val Ser Asp Asp Gln
180 185 190
Leu Ile Cys Ala Leu Cys Lys Leu Val Gly Arg His Arg Asp Hi s Gln
195 200 205
Val Ala Ser Leu Asn Asp Arg Phe Glu Lys Leu Lys Gln Thr Leu Glu
210 215 220
Met Asn Leu Thr Asn Leu Val Lys Arg Asn Ser Glu Leu Glu Asn Gln
225 230 235 240
Met Ala Lys Leu Ile Gln Ile Cys Gln Gln Val Glu Val Asn Thr Ala
245 250 255
Met His Glu Ala Lys Leu Met Glu Glu Cys Asp Glu Leu Val Glu Ile
260 265 270
Ile Gln Gln Arg Lys Gln Met Ile Ala Val Lys Ile Lys Glu Thr Lys
275 280 285
Val Met Lys Leu Arg Lys Leu Ala Gln Gln Val Ala Asn Cys Arg Gln
290 295 300
Cys Leu Glu Arg Ser Thr Val Leu Ile Asn Gln Ala Glu His Ile Leu
305 310 315 320
Lys Glu Asn Asp Gln Ala Arg Phe Leu Gln Ser Ala Lys Asn Ile Ala
325 330 335
Glu Arg Val Ala Met Ala Thr Ala Ser Ser Gln Val Leu Ile Pro Asp
340 345 350
lle Asn Phe Asn Asp Ala Phe Glu Asn Phe Ala Leu Asp Phe Ser Arg
355 360 365
Glu Lys Lys Leu Leu Glu Gly Leu Asp Tyr Leu Thr Ala Pro Asn Pro
370 375 380
Pro Ser Ile Arg Glu Glu Leu Cys Thr Ala Ser His Asp Thr Ile Thr
385 390 395 400
Val His Trp Ile Ser Asp Asp Glu Phe Ser Ile Ser Ser Tyr Glu Leu
405 410 415
Gln Tyr Thr Ile Phe Thr Gly Gln Ala Asn Phe Ile Ser Lys Ser Trp
420 425 430
Cys Ser Trp Gly Leu Trp Pro Glu Ile Arg Lys Cys Lys Glu Ala Val
435 440 445
Ser Cys Ser Arg Leu Ala Gly Ala Pro Arg Gly Leu Tyr Asn Ser Val
450 455 460
Asp Ser Trp Met Ile Val Pro Asn Ile Lys Gln Asn His Tyr Thr Val
465 470 475 480
His Gly Leu Gln Ser Gly Thr Arg Tyr Ile Phe Ile Val Lys Ala Ile
485 490 495
Asn Gln Ala Gly Ser Arg Asn Ser Glu Pro Thr Arg Leu Lys Thr Asn
500 505 510
Ser Gln Pro Phe Lys Leu Asp Pro Lys Met Thr His Lys Lys Leu Lys
515 520 525
Ile Ser Asn Asp Gly Leu Gln Met Glu Lys Asp Glu Ser Ser Leu Lys
530 535 540
Lys Ser His Thr Pro Glu Arg Phe Ser Gly Thr Gly Cys Tyr Gly Ala
545 550 555 560
Ala Gly Asn Ile Phe Ile Asp Ser Gly Cys His Tyr Trp Glu Val Val
565 570 575
Met Gly Ser Ser Thr Trp Tyr Ala Ile Gly Ile Ala Tyr Lys Ser Ala
580 585 590
Pro Lys Asn Glu Trp Ile Gly Lys Asn Ala Ser Ser Trp Val Phe Ser
595 600 605
Arg Cys Asn Ser Asn Phe Val Val Arg His Asn Asn Lys Glu Met Leu
610 615 620
Val Asp Val Pro Pro His Leu Lys Arg Leu Gly Val Leu Leu Asp Tyr
625 630 635 640
Asp Asn Asn Met Leu Ser Phe Tyr Asp Pro Ala Asn Ser Leu His Leu
645 650 655
His Thr Phe Asp Val Thr Phe Ile Leu Pro Val Cys Pro Thr Phe Thr
660 665 670
Ile Trp Asn Lys Ser Leu Met Ile Leu Ser Gly Leu Pro Ala Pro Asp
675 680 685
Phe Ile Asp Tyr Pro Glu Arg Gln Glu Cys Asn Cys Arg Pro Gln Glu
690 695 700
Ser Pro Tyr Val Ser Gly Met Lys Thr Cys His
705 710 715
<210>184
<211>1076
<212>PRT
<213>人
<400>184
Met Glu Pro Gly Ser Lys Ser Val Ser Arg Ser Asp Trp Gln Pro Glu
1 5 10 15
Pro His Gln Arg Pro Ile Thr Pro Leu Glu Pro Gly Pro Glu Lys Thr
20 25 30
Pro Ile Ala Gln Pro Glu Ser Lys Thr Leu Gln Gly Ser Asn Thr Gln
35 40 45
Gln Lys Pro Ala Ser Asn Gln Arg Pro Leu Thr Gln Gln Glu Thr Pro
50 55 60
Ala Gln His Asp Ala Glu Ser Gln Lys Glu Pro Arg Ala Gln Gln Lys
65 70 75 80
Ser Ala Ser Gln Glu Glu Phe Leu Ala Pro Gln Lys Pro Ala Pro Gln
85 90 95
Gln Ser Pro Tyr Ile Gln Arg Val Leu Leu Thr Gln Gln Glu Ala Ala
100 105 110
Ser Gln Gln Gly Pro Gly Leu Gly Lys Glu Ser Ile Thr Gln Gln Glu
115 120 125
Pro Ala Leu Arg Gln Arg His Val Ala Gln Pro Gly Pro Gly Pro Gly
130 135 140
Glu Pro Pro Pro Ala Gln Gln Glu Ala Glu Ser Thr Pro Ala Ala Gln
145 150 155 160
Ala Lys Pro Gly Ala Lys Arg Glu Pro Ser Ala Pro Thr Glu Ser Thr
165 170 175
Ser Gln Glu Thr Pro Glu Gln Ser Asp Lys Gln Thr Thr Pro Val Gln
180 185 190
Gly Ala Lys Ser Lys Gln Gly Ser Leu Thr Glu Leu Gly Phe Leu Thr
195 200 205
Lys Leu Gln Glu Leu Ser Ile Gln Arg Ser Ala Leu Glu Trp Lys Ala
210 215 220
Leu Ser Glu Trp Val Ala Asp Ser Glu Ser Glu Ser Asp Val Gly Ser
225 230 235 240
Ser Ser Asp Thr Asp Ser Pro Ala Thr Met Gly Gly Met Val Ala Gln
245 250 255
Gly Val Lys Leu Gly Phe Lys Gly Lys Ser Gly Tyr Lys Val Met Ser
260 265 270
Gly Tyr Ser Gly Thr Ser Pro His Glu Lys Thr Ser Ala Arg Asn His
275 280 285
Arg His Tyr Gln Asp Thr Ala Ser Arg Leu Ile His Asn Met Asp Leu
290 295 300
Arg Thr Met Thr Gln Ser Leu Val Thr Leu Ala Glu Asp Asn Ile Ala
305 310 315 320
Phe Phe Ser Ser Gln Gly Pro Gly Glu Thr Ala Gln Arg Leu Ser Gly
325 330 335
Val Phe Ala Gly Val Arg Glu Gln Ala Leu Gly Leu Glu Pro Ala Leu
340 345 350
Gly Arg Leu Leu Gly Val Ala His Leu Phe Asp Leu Asp Pro Glu Thr
355 360 365
Pro Ala Asn Gly Tyr Arg Ser Leu Val His Thr Ala Arg Cys Cys Leu
370 375 380
Ala His Leu Leu His Lys Ser Arg Tyr Val Ala Ser Asn Arg Arg Ser
385 390 395 400
Ile Phe Phe Arg Thr Ser His Asn Leu Ala Glu Leu Glu Ala Tyr Leu
405 410 415
Ala Ala Leu Thr Gln Leu Arg Ala Leu Val Tyr Tyr Ala Gln Arg Leu
420 425 430
Leu Val Thr Asn Arg Pro Gly Val Leu Phe Phe Glu Gly Asp Glu Gly
435 440 445
Leu Thr Ala Asp Phe Leu Arg Glu Tyr Val Thr Leu His Lys Gly Cys
450 455 460
Phe Tyr Gly Arg Cys Leu Gly Phe Gln Phe Thr Pro Ala Ile Arg Pro
465 470 475 480
Phe Leu Gln Thr Ile Ser Ile Gly Leu Val Ser Phe Gly Glu His Tyr
485 490 495
Lys Arg Asn Glu Thr Gly Leu Ser Val Ala Ala Ser Ser Leu Phe Thr
500 505 510
Ser Gly Arg Phe Ala Ile Asp Pro Glu Leu Arg Gly Ala Glu Phe Glu
515 520 525
Arg Ile Thr Gln Asn Leu Asp Val His Phe Trp Lys Ala Phe Trp Asn
530 535 540
Ile Thr Glu Met Glu Val Leu Ser Ser Leu Ala Asn Met Ala Ser Ala
545 550 555 560
Thr Val Arg Val Ser Arg Leu Leu Ser Leu Pro Pro Glu Ala Phe Glu
565 570 575
Met Pro Leu Thr Ala Asp Pro Thr Leu Thr Val Thr Ile Ser Pro Pro
580 585 590
Leu Ala His Thr Gly Pro Gly Pro Val Leu Val Arg Leu Ile Ser Tyr
595 600 605
Asp Leu Arg Glu Gly Gln Asp Ser Glu Glu Leu Ser Ser Leu Ile Lys
610 615 620
Ser Asn Gly Gln Arg Ser Leu Glu Leu Trp Pro Arg Pro Gln Gln Ala
625 630 635 640
Pro Arg Ser Arg Ser Leu Ile Val His Phe His Gly Gly Gly Phe Val
645 650 655
Ala Gln Thr Ser Arg Ser His Glu Pro Tyr Leu Lys Ser Trp Ala Gln
660 665 670
Glu Leu Gly Ala Pro Ile Ile Ser Ile Asp Tyr Ser Leu Ala Pro Glu
675 680 685
Ala Pro Phe Pro Arg Ala Leu Glu Glu Cys Phe Phe Ala Tyr Cys Trp
690 695 700
Ala Ile Lys His Cys Ala Leu Leu Gly Ser Thr Gly Glu Arg Ile Cys
705 710 715 720
Leu Ala Gly Asp Ser Ala Gly Gly Asn Leu Cys Phe Thr Val Ala Leu
725 730 735
Arg Ala Ala Ala Tyr Gly Val Arg Val Pro Asp Gly Ile Met Ala Ala
740 745 750
Tyr Pro Ala Thr Met Leu Gln Pro Ala Ala Ser Pro Ser Arg Leu Leu
755 760 765
Ser Leu Met Asp Pro Leu Leu Pro Leu Ser Val Leu Ser Lys Cys Val
770 775 780
Ser Ala Tyr Ala Gly Ala Lys Thr Glu Asp His Ser Asn Ser Asp Gln
785 790 795 800
Lys Ala Leu Gly Met Met Gly Leu Val Arg Arg Asp Thr Ala Leu Leu
805 810 815
Leu Arg Asp Phe Arg Leu Gly Ala Ser Ser Trp Leu Asn Ser Phe Leu
820 825 830
Glu Leu Ser Gly Arg Lys Ser Gln Lys Met Ser Glu Pro Ile Ala Glu
835 840 845
Pro Met Arg Arg Ser Val Ser Glu Ala Ala Leu Ala Gln Pro Gln Gly
850 855 860
Pro Leu Gly Thr Asp Ser Leu Lys Asn Leu Thr Leu Arg Asp Leu Ser
865 870 875 880
Leu Arg Gly Asn Ser Glu Thr Ser Ser Asp Thr Pro Glu Met Ser Leu
885 890 895
Ser Ala Glu Thr Leu Ser Pro Ser Thr Pro Ser Asp Val Asn Phe Leu
900 905 910
Leu Pro Pro Glu Asp Ala Gly Glu Glu Ala Glu Ala Lys Asn Glu Leu
915 920 925
Ser Pro Met Asp Arg Gly Leu Gly Val Arg Ala Ala Phe Pro Glu Gly
930 935 940
Phe His Pro Arg Arg Ser Ser Gln Gly Ala Thr Gln Met Pro Leu Tyr
945 950 955 960
Ser Ser Pro Ile Val Lys Asn Pro Phe Met Ser Pro Leu Leu Ala Pro
965 970 975
Asp Ser Met Leu Lys Ser Leu Pro Pro Val His Ile Val Ala Cys Ala
980 985 990
Leu Asp Pro Met Leu Asp Asp Ser Val Met Leu Ala Arg Arg Leu Arg
995 1000 1005
Asn Leu Gly Gln Pro Val Thr Leu Arg Val Val Glu Asp Leu Pro
1010 1015 1020
His Gly Phe Leu Thr Leu Ala Ala Leu Cys Arg Glu Thr Arg Gln
1025 1030 1035
Ala Ala Glu Leu Cys Val Glu Arg Ile Arg Leu Val Leu Thr Pro
1040 1045 1050
Pro Ala Gly Ala Gly Pro Ser Gly Glu Thr Gly Ala Ala Gly Val
1055 1060 1065
Asp Gly Gly Cys Gly Gly Arg His
1070 1075
<210>185
<211>1215
<212>PRT
<213>人
<400>185
Met Thr Ser Thr Gly Gln Asp Ser Thr Thr Thr Arg Gln Arg Arg Ser
1 5 10 15
Arg Gln Asn Pro Gln Ser Pro Pro Gln Asp Ser Ser Val Thr Ser Lys
20 25 30
Arg Asn Ile Lys Lys Gly Ala Val Pro Arg Ser Ile Pro Asn Leu Ala
35 40 45
Glu Val Lys Lys Lys Gly Lys Met Lys Lys Leu Gly Gln Ala Met Glu
50 55 60
Glu Asp Leu Ile Val Gly Leu Gln Gly Met Asp Leu Asn Leu Glu Ala
65 70 75 80
Glu Ala Leu Ala Gly Thr Gly Leu Val Leu Asp Glu Gln Leu Asn Glu
85 90 95
Phe His Cys Leu Trp Asp Asp Ser Phe Pro Glu Gly Pro Glu Arg Leu
100 105 110
His Ala Ile Lys Glu Gln Leu Ile Gln Glu Gly Leu Leu Asp Arg Cys
115 120 125
Val Ser Phe Gln Ala Arg Phe Ala Glu Lys Glu Glu Leu Met Leu Val
130 135 140
His Ser Leu Glu Tyr Ile Asp Leu Met Glu Thr Thr Gln Tyr Met Asn
145 150 155 160
Glu Gly Glu Leu Arg Val Leu Ala Asp Thr Tyr Asp Ser Val Tyr Leu
165 170 175
His Pro Asn Ser Tyr Ser Cys Ala Cys Leu Ala Ser Gly Ser Val Leu
180 185 190
Arg Leu Val Asp Ala Val Leu Gly Ala Glu Ile Arg Asn Gly Met Ala
195 200 205
Ile Ile Arg Pro Pro Gly His His Ala Gln His Ser Leu Met Asp Gly
210 215 220
Tyr Cys Met Phe Asn His Val Ala Val Ala Ala Arg Tyr Ala Gln Gln
225 230 235 240
Lys His Arg Ile Arg Arg Val Leu Ile Val Asp Trp Asp Val His His
245 250 255
Gly Gln Gly Thr Gln Phe Thr Phe Asp Gln Asp Pro Ser Val Leu Tyr
260 265 270
Phe Ser Ile His Arg Tyr Glu Gln Gly Arg Phe Trp Pro His Leu Lys
275 280 285
Ala Ser Asn Trp Ser Thr Thr Gly Phe Gly Gln Gly Gln Gly Tyr Thr
290 295 300
Ile Asn Val Pro Trp Asn Gln Val Gly Met Arg Asp Ala Asp Tyr Ile
305 310 315 320
Ala Ala Phe Leu His Val Leu Leu Pro Val Ala Leu Glu Phe Gln Pro
325 330 335
Gln Leu Val Leu Val Ala Ala Gly Phe Asp Ala Leu Gln Gly Asp Pro
340 345 350
Lys Gly Glu Met Ala Ala Thr Pro Ala Gly Phe Ala Gln Leu Thr His
355 360 365
Leu Leu Met Gly Leu Ala Gly Gly Lys Leu Ile Leu Ser Leu Glu Gly
370 375 380
Gly Tyr Asn Leu Arg Ala Leu Ala Glu Gly Val Ser Ala Ser Leu His
385 390 395 400
Thr Leu Leu Gly Asp Pro Cys Pro Met Leu Glu Ser Pro Gly Ala Pro
405 410 415
Cys Arg Ser Ala Gln Ala Ser Val Ser Cys Ala Leu Glu Ala Leu Glu
420 425 430
Pro Phe Trp Glu Val Leu Val Arg Ser Thr Glu Thr Val Glu Arg Asp
435 440 445
Asn Met Glu Glu Asp Asn Val Glu Glu Ser Glu Glu Glu Gly Pro Trp
450 455 460
Glu Pro Pro Val Leu Pro Ile Leu Thr Trp Pro Val Leu Gln Ser Arg
465 470 475 480
Thr Gly Leu Val Tyr Asp Gln Asn Met Met Asn His Cys Asn Leu Trp
485 490 495
Asp Ser His His Pro Glu Val Pro Gln Arg Ile Leu Arg Ile Met Cys
500 505 510
Arg Leu Glu Glu Leu Gly Leu Ala Gly Arg Cys Leu Thr Leu Thr Pro
515 520 525
Arg Pro Ala Thr Glu Ala Glu Leu Leu Thr Cys His Ser Ala Glu Tyr
530 535 540
Val Gly His Leu Arg Ala Thr Glu Lys Met Lys Thr Arg Glu Leu His
545 550 555 560
Arg Glu Ser Ser Asn Phe Asp Ser Ile Tyr Ile Cys Pro Ser Thr Phe
565 570 575
Ala Cys Ala Gln Leu Ala Thr Gly Ala Ala Cys Arg Leu Val Glu Ala
580 585 590
Val Leu Ser Gly Glu Val Leu Asn Gly Ala Ala Val Val Arg Pro Pro
595 600 605
Gly His His Ala Glu Gln Asp Ala Ala Cys Gly Phe Cys Phe Phe Asn
610 615 620
Ser Val Ala Val Ala Ala Arg His Ala Gln Thr Ile Ser Gly His Ala
625 630 635 640
Leu Arg Ile Leu Ile Val Asp Trp Asp Val His His Gly Asn Gly Thr
645 650 655
Gln His Met Phe Glu Asp Asp Pro Ser Val Leu Tyr Val Ser Leu His
660 665 670
Arg Tyr Asp His Gly Thr Phe Phe Pro Met Gly Asp Glu Gly Ala Ser
675 680 685
Ser Gln Ile Gly Arg Ala Ala Gly Thr Gly Phe Thr Val Asn Val Ala
690 695 700
Trp Asn Gly Pro Arg Met Gly Asp Ala Asp Tyr Leu Ala Ala Trp His
705 710 715 720
Arg Leu Val Leu Pro Ile Ala Tyr Glu Phe Asn Pro Glu Leu Val Leu
725 730 735
Val Ser Ala Gly Phe Asp Ala Ala Arg Gly Asp Pro Leu Gly Gly Cys
740 745 750
Gln Val Ser Pro Glu Gly Tyr Ala His Leu Thr His Leu Leu Met Gly
755 760 765
Leu Ala Ser Gly Arg Ile Ile Leu Ile Leu Glu Gly Gly Tyr Asn Leu
770 775 780
Thr Ser Ile Ser Glu Ser Met Ala Ala Cys Thr Arg Ser Leu Leu Gly
785 790 795 800
Asp Pro Pro Pro Leu Leu Thr Leu Pro Arg Pro Pro Leu Ser Gly Ala
805 810 815
Leu Ala Ser Ile Thr Glu Thr Ile Gln Val His Arg Arg Tyr Trp Arg
820 825 830
Ser Leu Arg Val Met Lys Val Glu Asp Arg Glu Gly Pro Ser Ser Ser
835 840 845
Lys Leu Val Thr Lys Lys Ala Pro Gln Pro Ala Lys Pro Arg Leu Ala
850 855 860
Glu Arg Met Thr Thr Arg Glu Lys Lys Val Leu Glu Ala Gly Met Gly
865 870 875 880
Lys Val Thr Ser Ala Ser Phe Gly Glu Glu Ser Thr Pro Gly Gln Thr
885 890 895
Asn Ser Glu Thr Ala Val Val Ala Leu Thr Gln Asp Gln Pro Ser Glu
900 905 910
Ala Ala Thr Gly Gly Ala Thr Leu Ala Gln Thr Ile Ser Glu Ala Ala
915 920 925
Ile Gly Gly Ala Met Leu Gly Gln Thr Thr Ser Glu Glu Ala Val Gly
930 935 940
Gly Ala Thr Pro Asp Gln Thr Thr Ser Glu Glu Thr Val Gly Gly Ala
945 950 955 960
Ile Leu Asp Gln Thr Thr Ser Glu Asp Ala Val Gly Gly Ala Thr Leu
965 970 975
Gly Gln Thr Thr Ser Glu Glu Ala Val Gly Gly Ala Thr Leu Ala Gln
980 985 990
Thr Ile Ser Glu Ala Ala Met Glu Gly Ala Thr Leu Asp Gln Thr Thr
995 1000 1005
Ser Glu Glu Ala Pro Gly Gly Thr Glu Leu Ile Gln Thr Pro Leu
1010 1015 1020
Ala Ser Ser Thr Asp His Gln Thr Pro Pro Thr Ser Pro Val Gln
1025 1030 1035
Gly Thr Thr Pro Gln Ile Ser Pro Ser Thr Leu Ile Gly Ser Leu
1040 1045 1050
Arg Thr Leu Glu Leu Gly Ser Glu Ser Gln Gly Ala Ser Glu Ser
1055 1060 1065
Gln Ala Pro Gly Glu Glu Asn Leu Leu Gly Glu Ala Ala Gly Gly
1070 1075 1080
Gln Asp Met Ala Asp Ser Met Leu Met Gln Gly Ser Arg Gly Leu
1085 1090 1095
Thr Asp Gln Ala Ile Phe Tyr Ala Val Thr Pro Leu Pro Trp Cys
1100 1105 1110
Pro His Leu Val Ala Val Cys Pro Ile Pro Ala Ala Gly Leu Asp
1115 1120 1125
Val Thr Gln Pro Cys Gly Asp Cys Gly Thr Ile Gln Glu Asn Trp
1130 1135 1140
Val Cys Leu Ser Cys Tyr Gln Val Tyr Cys Gly Arg Tyr Ile Asn
1145 1150 1155
Gly His Met Leu Gln His His Gly Asn Ser Gly His Pro Leu Val
1160 1165 1170
Leu Ser Tyr Ile Asp Leu Ser Ala Trp Cys Tyr Tyr Cys Gln Ala
1175 1180 1185
Tyr Val His His Gln Ala Leu Leu Asp Val Lys Asn Ile Ala His
1190 1195 1200
Gln Asn Lys Phe Gly Glu Asp Met Pro His Pro His
1205 1210 1215
<210>186
<211>780
<212>PRT
<213>人
<400>186
Met Ala Pro Tyr Ser Leu Leu Val Thr Arg Leu Gln Lys Ala Leu Gly
1 5 10 15
Val Arg Gln Tyr His Val Ala Ser Val Leu Cys Gln Arg Ala Lys Val
20 25 30
Ala Met Ser His Phe Glu Pro Asn Glu Tyr Ile His Tyr Asp Leu Leu
35 40 45
Glu Lys Asn Ile Asn Ile Val Arg Lys Arg Leu Asn Arg Pro Leu Thr
50 55 60
Leu Ser Glu Lys Ile Val Tyr Gly His Leu Asp Asp Pro Ala Ser Gln
65 70 75 80
Glu Ile Glu Arg Gly Lys Ser Tyr Leu Arg Leu Arg Pro Asp Arg Val
85 90 95
Ala Met Gln Asp Ala Thr Ala Gln Met Ala Met Leu Gln Phe Ile Ser
100 105 110
Ser Gly Leu Ser Lys Val Ala Val Pro Ser Thr Ile His Cys Asp His
115 120 125
Leu Ile Glu Ala Gln Val Gly Gly Glu Lys Asp Leu Arg Arg Ala Lys
130 135 140
Asp Ile Asn Gln Glu Val Tyr Asn Phe Leu Ala Thr Ala Gly Ala Lys
145 150 155 160
Tyr Gly Val Gly Phe Trp Lys Pro Gly Ser Gly Ile Ile His Gln Ile
165 170 175
Ile Leu Glu Asn Tyr Ala Tyr Pro Gly Val Leu Leu Ile Gly Thr Asp
180 185 190
Ser His Thr Pro Asn Gly Gly Gly Leu Gly Gly Ile Cys Ile Gly Val
195 200 205
Gly Gly Ala Asp Ala Val Asp Val Met Ala Gly Ile Pro Trp Glu Leu
210 215 220
Lys Cys Pro Lys Val Ile Gly Val Lys Leu Thr Gly Ser Leu Ser Gly
225 230 235 240
Trp Ser Ser Pro Lys Asp Val Ile Leu Lys Val Ala Gly Ile Leu Thr
245 250 255
Val Lys Gly Gly Thr Gly Ala Ile Val Glu Tyr His Gly Pro Gly Val
260 265 270
Asp Ser Ile Ser Cys Thr Gly Met Ala Thr Ile Cys Asn Met Gly Ala
275 280 285
Glu Ile Gly Ala Thr Thr Ser Val Phe Pro Tyr Asn His Arg Met Lys
290 295 300
Lys Tyr Leu Ser Lys Thr Gly Arg Glu Asp Ile Ala Asn Leu Ala Asp
305 310 315 320
Glu Phe Lys Asp His Leu Val Pro Asp Pro Gly Cys His Tyr Asp Gln
325 330 335
Leu Ile Glu Ile Asn Leu Ser Glu Leu Lys Pro His Ile Asn Gly Pro
340 345 350
Phe Thr Pro Asp Leu Ala His Pro Val Ala Glu Val Gly Lys Val Ala
355 360 365
Glu Lys Glu Gly Trp Pro Leu Asp Ile Arg Val Gly Leu Ile Gly Ser
370 375 380
Cys Thr Asn Ser Ser Tyr Glu Asp Met Gly Arg Ser Ala Ala Val Ala
385 390 395 400
Lys Gln Ala Leu Ala His Gly Leu Lys Cys Lys Ser Gln Phe Thr Ile
405 410 415
Thr Pro Gly Ser Glu Gln Ile Arg Ala Thr Ile Glu Arg Asp Gly Tyr
420 425 430
Ala Gln Ile Leu Arg Asp Leu Gly Gly Ile Val Leu Ala Asn Ala Cys
435 440 445
Gly Pro Cys Ile Gly Gln Trp Asp Arg Lys Asp Ile Lys Lys Gly Glu
450 455 460
Lys Asn Thr Ile Val Thr Ser Tyr Asn Arg Asn Phe Thr Gly Arg Asn
465 470 475 480
Asp Ala Asn Pro Glu Thr His Ala Phe Val Thr Ser Pro Glu Ile Val
485 490 495
Thr Ala Leu Ala Ile Ala Gly Thr Leu Lys Phe Asn Pro Glu Thr Asp
500 505 510
Tyr Leu Thr Gly Thr Asp Gly Lys Lys Phe Arg Leu Glu Ala Pro Asp
515 520 525
Ala Asp Glu Leu Pro Lys Gly Glu Phe Asp Pro Gly Gln Asp Thr Tyr
530 535 540
Gln His Pro Pro Lys Asp Ser Ser Gly Gln His Val Asp Val Ser Pro
545 550 555 560
Thr Ser Gln Arg Leu Gln Leu Leu Glu Pro Phe Asp Lys Trp Asp Gly
565 570 575
Lys Asp Leu Glu Asp Leu Gln Ile Leu Ile Lys Val Lys Gly Lys Cys
580 585 590
Thr Thr Asp His Ile Ser Ala Ala Gly Pro Trp Leu Lys Phe Arg Gly
595 600 605
His Leu Asp Asn Ile Ser Asn Asn Leu Leu Ile Gly Ala Ile Asn Ile
610 615 620
Glu Asn Gly Lys Ala Asn Ser Val Arg Asn Ala Val Thr Gln Glu Phe
625 630 635 640
Gly Pro Val Pro Asp Thr Ala Arg Tyr Tyr Lys Lys His Gly Ile Arg
645 650 655
Trp Val Val Ile Gly Asp Glu Asn Tyr Gly Glu Gly Ser Ser Arg Glu
660 665 670
His Ala Ala Leu Glu Pro Arg His Leu Gly Gly Arg Ala Ile Ile Thr
675 680 685
Lys Ser Phe Ala Arg Ile His Glu Thr Asn Leu Lys Lys Gln Gly Leu
690 695 700
Leu Pro Leu Thr Phe Ala Asp Pro Ala Asp Tyr Asn Lys Ile His Pro
705 710 715 720
Val Asp Lys Leu Thr Ile Gln Gly Leu Lys Asp Phe Thr Pro Gly Lys
725 730 735
Pro Leu Lys Cys Ile Ile Lys His Pro Asn Gly Thr Gln Glu Thr Ile
740 745 750
Ieu Leu Asn His Thr Phe Asn Glu Thr Gln Ile Glu Trp Phe Arg Ala
755 760 765
Gly Ser Ala Leu Asn Arg Met Lys Glu Leu Gln Gln
770 775 780
<210>187
<211>650
<212>PRT
<213>人
<400>187
Met Gly Pro Ala Ser Pro Ala Ala Arg Gly Leu Ser Arg Arg Pro Gly
1 5 10 15
Gln Pro Pro Leu Pro Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Arg
20 25 30
Ala Gln Pro Ala Ile Gly Ser Leu Ala Gly Gly Ser Pro Gly Ala Ala
35 40 45
Glu Ala Pro Gly Ser Ala Gln Val Ala Gly Leu Cys Gly Arg Leu Thr
50 55 60
Leu His Arg Asp Leu Arg Thr Gly Arg Trp Glu Pro Asp Pro Gln Arg
65 70 75 80
Ser Arg Arg Cys Leu Arg Asp Pro Gln Arg Val Leu Glu Tyr Cys Arg
85 90 95
Gln Met Tyr Pro Glu Leu Gln Ile Ala Arg Val Glu Gln Ala Thr Gln
100 105 110
Ala Ile Pro Met Glu Arg Trp Cys Gly Gly Ser Arg Ser Gly Ser Cys
115 120 125
Ala His Pro His His Gln Val Val Pro Phe Arg Cys Leu Pro Gly Glu
130 135 140
Phe Val Ser Glu Ala Leu Leu Val Pro Glu Gly Cys Arg Phe Leu His
145 150 155 160
Gln Glu Arg Met Asp Gln Cys Glu Ser Ser Thr Arg Arg His Gln Glu
165 170 175
Ala Gln Glu Ala Cys Ser Ser Gln Gly Leu Ile Leu His Gly Ser Gly
180 185 190
Met Leu Leu Pro Cys Gly Ser Asp Arg Phe Arg Gly Val Glu Tyr Val
195 200 205
Cys Cys Pro Pro Pro Gly Thr Pro Asp Pro Ser Gly Thr Ala Val Gly
210 215 220
Asp Pro Ser Thr Arg Ser Trp Pro Pro Gly Ser Arg Val Glu Gly Ala
225 230 235 240
Glu Asp Glu Glu Glu Glu Glu Ser Phe Pro Gln Pro Val Asp Asp Tyr
245 250 255
Phe Val Glu Pro Pro Gln Ala Glu Glu Glu Glu Glu Thr Val Pro Pro
260 265 270
Pro Ser Ser His Thr Leu Ala Val Val Gly Lys Val Thr Pro Thr Pro
275 280 285
Arg Pro Thr Asp Gly Val Asp Ile Tyr Phe Gly Met Pro Gly Glu Ile
290 295 300
Ser Glu His Glu Gly Phe Leu Arg Ala Lys Met Asp Leu Glu Glu Arg
305 310 315 320
Arg Met Arg Gln Ile Asn Glu Val Met Arg Glu Trp Ala Met Ala Asp
325 330 335
Asn Gln Ser Lys Asn Leu Pro Lys Ala Asp Arg Gln Ala Leu Asn Glu
340 345 350
His Phe Gln Ser Ile Leu Gln Thr Leu Glu Glu Gln Val Ser Gly Glu
355 360 365
Arg Gln Arg Leu Val Glu Thr His Ala Thr Arg Val Ile Ala Leu Ile
370 375 380
Asn Asp Gln Arg Arg Ala Ala Leu Glu Gly Phe Leu Ala Ala Leu Gln
385 390 395 400
Ala Asp Pro Pro Gln Ala Glu Arg Val Leu Leu Ala Leu Arg Arg Tyr
405 410 415
Leu Arg Ala Glu Gln Lys Glu Gln Arg His Thr Leu Arg His Tyr Gln
420 425 430
His Val Ala Ala Val Asp Pro Glu Lys Ala Gln Gln Met Arg Phe Gln
435 440 445
Val His Thr His Leu Gln Val Ile Glu Glu Arg Val Asn Gln Ser Leu
450 455 460
Gly Leu Leu Asp Gln Asn Pro His Leu Ala Gln Glu Leu Arg Pro Gln
465 470 475 480
Ile Gln Glu Leu Leu His Ser Glu His Leu Gly Pro Ser Glu Leu Glu
485 490 495
Ala Pro Ala Pro Gly Gly Ser Ser Glu Asp Lys Gly Gly Leu Gln Pro
500 505 510
Pro Asp Ser Lys Asp Asp Thr Pro Met Thr Leu Pro Lys Gly Ser Thr
515 520 525
Glu Gln Asp Ala Ala Ser Pro Glu Lys Glu Lys Met Asn Pro Leu Glu
530 535 540
Gln Tyr Glu Arg Lys Val Asn Ala Ser Val Pro Arg Gly Phe Pro Phe
545 550 555 560
His Ser Ser Glu Ile Gln Arg Asp Glu Leu Ala Pro Ala Gly Thr Gly
565 570 575
Val Ser Arg Glu Ala Val Ser Gly Leu Leu Ile Met Gly Ala Gly Gly
580 585 590
Gly Ser Leu Ile Val Leu Ser Met Leu Leu Leu Arg Arg Lys Lys Pro
595 600 605
Tyr Gly Ala Ile Ser His Gly Val Val Glu Val Asp Pro Met Leu Thr
610 615 620
Leu Glu Glu Gln Gln Leu Arg Glu Leu Gln Arg His Gly Tyr Glu Asn
625 630 635 640
Pro Thr Tyr Arg Phe Leu Glu Glu Arg Pro
645 650
<210>188
<211>651
<213>人
<400>188
Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val
1 5 10 15
Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val
20 25 30
Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu
35 40 45
Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg
50 55 60
Leu Lys Ala Glu Arg Lys Phe Phe Lys Gly Phe Phe Gly Lys Thr Gly
65 70 75 80
Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser Ala Asp Gly Leu Arg
85 90 95
Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val Asp Gln Thr Ile Glu
100 105 110
Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe Asp Arg Ala Phe Ser
115 120 125
Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp Ile Cys His Cys Phe
130 135 140
Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser His Ala Val Gly Cys
145 150 155 160
Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys Arg Glu Lys Glu Cys
165 170 175
Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr Thr Phe Thr Arg Glu
180 185 190
Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln Ala Glu Arg Glu Glu
195 200 205
Ile Met Lys Gln Met Gln Asp Ala Lys Lys Ala Glu Thr Asp Lys Ile
210 215 220
Val Val Gly Ser Ser Val Ala Pro Gly Asn Thr Ala Pro Ser Pro Ser
225 230 235 240
Ser Pro Thr Ser Pro Thr Ser Asp Ala Thr Thr Ser Leu Glu Met Asn
245 250 255
Asn Pro His Ala Ile Pro Arg Arg His Ala Pro Ile Glu Gln Leu Ala
260 265 270
Arg Gln Gly Ser Phe Arg Gly Phe Pro Ala Leu Ser Gln Lys Met Ser
275 280 285
Pro Phe Lys Arg Gln Leu Ser Leu Arg Ile Asn Glu Leu Pro Ser Thr
290 295 300
Met Gln Arg Lys Thr Asp Phe Pro Ile Lys Asn Ala Val Pro Glu Val
305 310 315 320
Glu Gly Glu Ala Glu Ser Ile Ser Ser Leu Cys Ser Gln Ile Thr Asn
325 330 335
Ala Phe Ser Thr Pro Glu Asp Pro Phe Ser Ser Ala Pro Met Thr Lys
340 345 350
Pro Val Thr Val Val Ala Pro Gln Ser Pro Thr Phe Gln Ala Asn Gly
355 360 365
Thr Asp Ser Ala Phe His Val Leu Ala Lys Pro Ala His Thr Ala Leu
370 375 380
Ala Pro Val Ala Met Pro Val Arg Glu Thr Asn Pro Trp Ala His Ala
385 390 395 400
Pro Asp Ala Ala Asn Lys Glu Ile Ala Ala Thr Cys Ser Gly Thr Glu
405 410 415
Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly Leu Phe Gln Ala Gly
420 425 430
His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp Leu Glu Glu Val Ser
435 440 445
Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser Ala Ala Pro Leu Gln
450 455 460
Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile Ser Gln Pro Ala Ser
465 470 475 480
Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln Pro Val Pro Val Gly
485 490 495
Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro Ala Gln Ser Tyr Pro
500 505 510
Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn Val Pro Val Val Gly
515 520 525
Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe Gly Thr Ala Gly His
530 535 540
Pro Gln Ala Ala His Pro His Gln Ser Pro Ser Leu Val Arg Gln Gln
545 550 555 560
Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr Thr Ser Pro Phe Phe
565 570 575
Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala Ala Phe Asn Gly Val
580 585 590
Asp Asp Gly Arg Leu Ala ser Ala Asp Arg His Thr Glu Val Pro Thr
595 600 605
Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln Trp Ala Ala Leu Glu
610 615 620
Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro Thr Asn Pro Phe Ser
625 630 635 640
Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu
645 650
<210>189
<211>803
<212>PRT
<213>人
<400>189
Met Asn Ser Ala Glu Gln Thr Val Thr Trp Leu Ile Thr Leu Gly Val
1 5 10 15
Leu Glu Ser Pro Lys Lys Thr Ile Ser Asp Pro Glu Gly Phe Leu Gln
20 25 30
Ala Ser Leu Lys Asp Gly Val Val Leu Cys Arg Leu Leu Glu Arg Leu
35 40 45
Leu Pro Gly Thr Ile Glu Lys Val Tyr Pro Glu Pro Arg Ser Glu Ser
50 55 60
Glu Cys Leu Ser Asn Ile Arg Glu Phe Leu Arg Gly Cys Gly Ala Ser
65 70 75 80
Leu Arg Leu Glu Leu Leu Phe Pro Pro Ser Gln Pro Pro Gln His Leu
85 90 95
Val Thr Thr Ile Leu Leu Ser Ala Ser Thr Phe Asp Ala Asn Asp Leu
100 105 110
Tyr Gln Gly Gln Asn Phe Asn Lys Val Leu Ser Ser Leu Val Thr Leu
115 120 125
Asn Lys Val Thr Ala Asp Ile Gly Leu Gly Ser Asp Ser Val Cys Ala
130 135 140
Arg Pro Ser Ser His Arg Ile Lys Ser Phe Asp Ser Leu Gly Ser Gln
145 150 155 160
Ser Leu His Thr Arg Thr Ser Lys Leu Phe Gln Gly Gln Tyr Arg Ser
165 170 175
Leu Asp Met Thr Asp Asn Ser Asn Asn Gln Leu Val Val Arg Ala Lys
180 185 190
Phe Asn Phe Gln Gln Thr Asn Glu Asp Glu Leu Ser Phe Ser Lys Gly
195 200 205
Asp Val Ile His Val Thr Arg Val Glu Glu Gly Gly Trp Trp Glu Gly
210 215 220
Thr Leu Asn Gly Arg Thr Gly Trp Phe Pro Ser Asn Tyr Val Arg Glu
225 230 235 240
Val Lys Ala Ser Glu Lys Pro Val Ser Pro Lys Ser Gly Thr Leu Lys
245 250 255
Ser Pro Pro Lys Gly Phe Asp Thr Thr Ala Ile Asn Lys Ser Tyr Tyr
260 265 270
Asn Val Val Leu Gln Asn Ile Leu Glu Thr Glu Asn Glu Tyr Ser Lys
275 280 285
Glu Leu Gln Thr Val Leu Ser Thr Tyr Leu Arg Pro Leu Gln Thr Ser
290 295 300
Glu Lys Leu Ser Ser Ala Asn Ile Ser Tyr Leu Met Gly Asn Leu Glu
305 310 315 320
Glu Ile Cys Ser Phe Gln Gln Met Leu Val Gln Ser Leu Glu Glu Cys
325 330 335
Thr Lys Leu Pro Glu Ala Gln Gln Arg Val Gly Gly Cys Phe Leu Asn
340 345 350
Leu Met Pro Gln Met Lys Thr Leu Tyr Leu Thr Tyr Cys Ala Asn His
355 360 365
Pro Ser Ala Val Asn Val Leu Thr Glu His Ser Glu Glu Leu Gly Glu
370 375 380
Phe Met Glu Thr Lys Gly Ala Ser Ser Pro Gly Ile Leu Val Leu Thr
385 390 395 400
Thr Gly Leu Ser Lys Pro Phe Met Arg Leu Asp Lys Tyr Pro Thr Leu
405 410 415
Leu Lys Glu Leu Glu Arg His Met Glu Asp Tyr His Thr Asp Arg Gln
420 425 430
Asp Ile Gln Lys Ser Met Ala Ala Phe Lys Asn Leu Ser Ala Gln Cys
435 440 445
Gln Glu Val Arg Lys Arg Lys Glu Leu Glu Leu Gln Ile Leu Thr Glu
450 455 460
Ala Ile Arg Asn Trp Glu Gly Asp Asp Ile Lys Thr Leu Gly Asn Val
465 470 475 480
Thr Tyr Met Ser Gln Val Leu Ile Gln Cys Ala Gly Ser Glu Glu Lys
485 490 495
Asn Glu Arg Tyr Leu Leu Leu Phe Pro Asn Val Leu Leu Met Leu Ser
500 505 510
Ala Ser Pro Arg Met Ser Gly Phe Ile Tyr Gln Gly Lys Leu Pro Thr
515 520 525
Thr Gly Met Thr Ile Thr Lys Leu Glu Asp Ser Glu Asn His Arg Asn
530 535 540
Ala Phe Glu Ile Ser Gly Ser Met Ile Glu Arg Ile Leu Val Ser Cys
545 550 555 560
Asn Asn Gln Gln Asp Leu Gln Glu Trp Val Glu His Leu Gln Lys Gln
565 570 575
Thr Lys Val Thr Ser Val Gly Asn Pro Thr Ile Lys Pro His Ser Val
580 585 590
Pro Ser His Thr Leu Pro Ser His Pro Val Thr Pro Ser Ser Lys His
595 600 605
Ala Asp Ser Lys Pro Ala Pro Leu Thr Pro Ala Tyr His Thr Leu Pro
610 615 620
His Pro Ser His His Gly Thr Pro His Thr Thr Ile Asn Trp Gly Pro
625 630 635 640
Leu Glu Pro Pro Lys Thr Pro Lys Pro Trp Ser Leu Ser Cys Leu Arg
645 650 655
Pro Ala Pro Pro Leu Arg Pro Ser Ala Ala Leu Cys Tyr Lys Glu Asp
660 665 670
Leu Ser Lys Ser Pro Lys Thr Met Lys Lys Leu Leu Pro Lys Arg Lys
675 680 685
Pro Glu Arg Lys Pro Ser Asp Glu Glu Phe Ala Ser Arg Lys Ser Thr
690 695 700
Ala Ala Leu Glu Glu Asp Ala Gln Ile Leu Lys Val Ile Glu Ala Tyr
705 710 715 720
Cys Thr Ser Ala Lys Thr Arg Gln Thr Leu Asn Ser Thr Trp Gln Gly
725 730 735
Thr Asp Leu Met His Asn His Val Leu Ala Asp Asp Asp Gln Pro Ser
740 745 750
Leu Asp Ser Leu Gly Arg Arg Ser Ser Leu Ser Arg Leu Glu Pro Ser
755 760 765
Asp Leu Ser Glu Asp Ser Asp Tyr Asp Ser Ile Trp Thr Ala His Ser
770 775 780
Tyr Arg Met Gly Ser Thr Ser Arg Lys Ser Cys Cys Ser Tyr Ile Ser
785 790 795 800
His Gln Asn
<210>190
<211>353
<212>PRT
<213>人
<400>190
Met Ala Cys Cys Leu Ser Glu Glu Ala Lys Glu Ala Arg Arg Ile Asn
1 5 10 15
Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp Lys Arg Asp Ala Arg Arg
20 25 30
Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly Glu Ser Gly Lys Ser Thr
35 40 45
Phe Ile Lys Gln Met Arg Ile Ile His Gly Ser Gly Tyr Ser Asp Glu
50 55 60
Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr Gln Asn Ile Phe Thr Ala
65 70 75 80
Met Gln Ala Met Ile Arg Ala Met Asp Thr Leu Lys Ile Pro Tyr Lys
85 90 95
Tyr Glu His Asn Lys Ala His Ala Gln Leu Val Arg Glu Val Asp Val
100 105 110
Glu Lys Val Ser Ala Phe Glu Asn Pro Tyr Val Asp AlaIle Lys Ser
115 120 125
Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys Tyr Asp Arg Arg Arg Glu
130 135 140
Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr Leu Asn Asp Leu Asp Arg
145 150 155 160
Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln Gln Asp Val Leu Arg Val
165 170 175
Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr Pro Phe Asp Leu Gln Ser
180 185 190
Val Ile Phe Arg Met Val Asp Val Gly Gly Gln Arg Ser Glu Arg Arg
195 200 205
Lys Trp Ile His Cys Phe Glu Asn Val Thr Ser Ile Met Phe Leu Val
210 215 220
Ala Leu Ser Glu Tyr Asp Gln Val Leu Val Glu Ser Asp Asn Glu Asn
225 230 235 240
Arg Met Glu Glu Ser Lys Ala Leu Phe Arg Thr Ile Ile Thr Tyr Pro
245 250 255
Trp Phe Gln Asn Ser Ser Val Ile Leu Phe Leu Asn Lys Lys Asp Leu
260 265 270
Leu Glu Glu Lys Ile Met Tyr Ser His Leu Val Asp Tyr Phe Pro Glu
275 280 285
Tyr Asp Gly Pro Gln Arg Asp Ala Gln Ala Ala Arg Glu Phe Ile Leu
290 295 300
Lys Met Phe Val Asp Leu Asn Pro Asp Ser Asp Lys Ile Ile Tyr Ser
305 310 315 320
His Phe Thr Cys Ala Thr Asp Thr Glu Asn Ile Arg Phe Val Phe Ala
325 330 335
Ala Val Lys Asp Thr Ile Leu Gln Leu Asn Leu Lys Glu Tyr Asn Leu
340 345 350
Val
<210>191
<211>394
<212>PRT
<213>人
<400>191
Met Ala Leu Leu Asp Leu Ala Leu Glu Gly Met Ala Val Phe Gly Phe
1 5 10 15
Aal Leu Phe Leu Val Leu Trp Leu Met His Phe Met Ala Ile Ile Tyr
20 25 30
Thr Arg Leu His Leu Asn Lys Lys Ala Thr Asp Lys Gln Pro Tyr Ser
35 40 45
Lys Leu Pro Gly Val Ser Leu Leu Lys Pro Leu Lys Gly Val Asp Pro
50 55 60
Asn Leu Ile Asn Asn Leu Glu Thr Phe Phe Glu Leu Asp Tyr Pro Lys
65 70 75 80
Tyr Glu Val Leu Leu Cys Val Gln Asp His Asp Asp Pro Ala Ile Asp
85 90 95
Val Cys Lys Lys Leu Leu Gly Lys Tyr Pro Asn Val Asp Ala Arg Leu
100 105 110
Phe Ile Gly Gly Lys Lys Val Gly Ile Asn Pro Lys Ile Asn Asn Leu
115 120 125
Met Pro Gly Tyr Glu Val Ala Lys Tyr Asp Leu Ile Trp Ile Cys Asp
130 135 140
Ser Gly Ile Arg Val Ile Pro Asp Thr Leu Thr Asp Met Val Asn Gln
145 150 155 160
Met Thr Glu Lys Val Gly Leu Val His Gly Leu Pro Tyr Val Ala Asp
165 170 175
Arg Gln Gly Phe Ala Ala Thr Leu Glu Gln Val Tyr Phe Gly Thr Ser
180 185 190
His Pro Arg Tyr Tyr Ile Ser Ala Asn Val Thr Gly Phe Lys Cys Val
195 200 205
Thr Gly Met Ser Cys Leu Met Arg Lys Asp Val Leu Asp Gln Ala Gly
210 215 220
Gly Leu Ile Ala Phe Ala Gln Tyr Ile Ala Glu Asp Tyr Phe Met Ala
225 230 235 240
Lys Ala Ile Ala Asp Arg Gly Trp Arg Phe Ala Met Ser Thr Gln Val
245 250 255
Ala Met Gln Asn Ser Gly Ser Tyr Ser Ile Ser Gln Phe Gln Ser Arg
260 265 270
Met Ile Arg Trp Thr Lys Leu Arg Ile Asn Met Leu Pro Ala Thr Ile
275 280 285
Ile Cys Glu Pro Ile Ser Glu Cys Phe Val Ala Ser Leu Ile Ile Gly
290 295 300
Trp Ala Ala His His Val Phe Arg Trp Asp Ile Met Val Phe Phe Met
305 310 315 320
Cys His Cys Leu Ala Trp Phe Ile Phe Asp Tyr Ile Gln Leu Arg Gly
325 330 335
Val Gln Gly Gly Thr Leu Cys Phe Ser Lys Leu Asp Tyr Ala Val Ala
340 345 350
Trp Phe Ile Arg Glu Ser Met Thr Ile Tyr Ile Phe Leu Ser Ala Leu
355 360 365
Trp Asp Pro Thr Ile Ser Trp Arg Thr Gly Arg Tyr Arg Leu Arg Cys
370 375 380
Gly Gly Thr Ala Glu Glu Ile Leu Asp Val
385 390
<210>192
<211>660
<212>PRT
<213>人
<400>192
Met Glu Ala Leu Met Ala Arg Gly Ala Leu Thr Gly Pro Leu Arg Ala
1 5 10 15
Leu Cys Leu Leu Gly Cys Leu Leu Ser His Ala Ala Ala Ala Pro Ser
20 25 30
Pro Ile Ile Lys Phe Pro Gly Asp Val Ala Pro Lys Thr Asp Lys Glu
35 40 45
Leu Ala Val Gln Tyr Leu Asn Thr Phe Tyr Gly Cys Pro Lys Glu Ser
50 55 60
Cys Asn Leu Phe Val Leu Lys Asp Thr Leu Lys Lys Met Gln Lys Phe
65 70 75 80
Phe Gly Leu Pro Gln Thr Gly Asp Leu Asp Gln Asn Thr Ile Glu Thr
85 90 95
Met Arg Lys Pro Arg Cys Gly Asn Pro Asp Val Ala Asn Tyr Asn Phe
100 105 110
Phe Pro Arg Lys Pro Lys Trp Asp Lys Asn Gln Ile Thr Tyr Arg Ile
115 120 125
Ile Gly Tyr Thr Pro Asp Leu Asp Pro Glu Thr Val Asp Asp Ala Phe
130 135 140
Ala Arg Ala Phe Gln Val Trp Ser Asp Val Thr Pro Leu Arg Phe Ser
145 150 155 160
Arg Ile His Asp Gly Glu Ala Asp Ile Met Ile Asn Phe Gly Arg Trp
165 170 175
Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala
180 185 190
His Ala Phe Ala Pro Gly Thr Gly Val Gly Gly Asp Ser His Phe Asp
195 200 205
Asp Asp Glu Leu Trp Thr Leu Gly Glu Gly Gln Val Val Arg Val Lys
210 215 220
Tyr Gly Asn Ala Asp Gly Glu Tyr Cys Lys Phe Pro Phe Leu Phe Asn
225 230 235 240
Gly Lys Glu Tyr Asn Ser Cys Thr Asp Thr Gly Arg Ser Asp Gly Phe
245 250 255
Leu Trp Cys Ser Thr Thr Tyr Asn Phe Glu Lys Asp Gly Lys Tyr Gly
260 265 270
Phe Cys Pro His Glu Ala Leu Phe Thr Met Gly Gly Asn Ala Glu Gly
275 280 285
Gln Pro Cys Lys Phe Pro Phe Arg Phe Gln Gly Thr Ser Tyr Asp Ser
290 295 300
Cys Thr Thr Glu Gly Arg Thr Asp Gly Tyr Arg Trp Cys Gly Thr Thr
305 310 315 320
Glu Asp Tyr Asp Arg Asp Lys Lys Tyr Gly Phe Cys Pro Glu Thr Ala
325 330 335
Met Ser Thr Val Gly Gly Asn Ser Glu Gly Ala Pro Cys Val Phe Pro
340 345 350
Phe Thr Phe Leu Gly Asn Lys Tyr Glu Ser Cys Thr Ser Ala Gly Arg
355 360 365
Ser Asp Gly Lys Met Trp Cys Ala Thr Thr Ala Asn Tyr Asp Asp Asp
370 375 380
Arg Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val
385 390 395 400
Ala Ala His Glu Phe Gly His Ala Met Gly Leu Glu His Ser Gln Asp
405 410 415
Pro Gly Ala Leu Met Ala Pro Ile Tyr Thr Tyr Thr Lys Asn Phe Arg
420 425 430
Leu Ser Gln Asp Asp Ile Lys Gly Ile Gln Glu Leu Tyr Gly Ala Ser
435 440 445
Pro Asp Ile Asp Leu Gly Thr Gly Pro Thr Pro Thr Leu Gly Pro Val
450 455 460
Thr Pro Glu Ile Cys Lys Gln Asp Ile Val Phe Asp Gly Ile Ala Gln
465 470 475 480
Ile Arg Gly Glu Ile Phe Phe Phe Lys Asp Arg Phe Ile Trp Arg Thr
485 490 495
Val Thr Pro Arg Asp Lys Pro Met Gly Pro Leu Leu Val Ala Thr Phe
500 505 510
Trp Pro Glu Leu Pro Glu Lys Ile Asp Ala Val Tyr Glu Ala Pro Gln
515 520 525
Glu Glu Lys Ala Val Phe Phe Ala Gly Asn Glu Tyr Trp Ile Tyr Ser
530 535 540
Ala Ser Thr Leu Glu Arg Gly Tyr Pro Lys Pro Leu Thr Ser Leu Gly
545 550 555 560
Leu Pro Pro Asp Val Gln Arg Val Asp Ala Ala Phe Asn Trp Ser Lys
565 570 575
Asn Lys Lys Thr Tyr Ile Phe Ala Gly Asp Lys Phe Trp Arg Tyr Asn
580 585 590
Glu Val Lys Lys Lys Met Asp Pro Gly Phe Pro Lys Leu Ile Ala Asp
595 600 605
Ala Trp Asn Ala Ile Pro Asp Asn Leu Asp Ala Val Val Asp Leu Gln
610 615 620
Gly Gly Gly His Ser Tyr Phe Phe Lys Gly Ala Tyr Tyr Leu Lys Leu
625 630 635 640
Glu Asn Gln Ser Leu Lys Ser Val Lys Phe Gly Ser Ile Lys Ser Asp
645 650 655
Trp Leu Gly Cys
660
<210>193
<211>260
<212>PRT
<213>人
<400>193
Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val
1 5 10 15
Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr
20 25 30
Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe
35 40 45
Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro
50 55 60
Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His
65 70 75 80
Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys
85 90 95
Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys
100 105 110
Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu
115 120 125
Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His
130 135 140
Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met
145 150 155 160
Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr
165 170 175
His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile
180 185 190
Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala
195 200 205
Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser
210 215 220
Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu
225 230 235 240
Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro
245 250 255
Ala Cys Ser Pro
260
<210>194
<211>885
<212>PRT
<213>人
<400>194
Met Gly Cys Ala Pro Ser Ile His Val Ser Gln Ser Gly Val Ile Tyr
1 5 10 15
Cys Arg Asp Ser Asp Glu Ser Ser Ser Pro Arg Gln Thr Thr Ser Val
20 25 30
Ser Gln Gly Pro Ala Ala Pro Leu Pro Gly Leu Phe Val Gln Thr Asp
35 40 45
Ala Ala Asp Ala Ile Pro Pro Ser Arg Ala Ser Gly Pro Pro Ser Val
50 55 60
Ala Arg Val Arg Arg Ala Arg Thr Glu Leu Gly Ser Gly Ser Ser Ala
65 70 75 80
Gly Ser Ala Ala Pro Ala Ala Thr Thr Ser Arg Gly Arg Arg Arg His
85 90 95
Cys Cys Ser Ser Ala Glu Ala Glu Thr Gln Thr Cys Tyr Thr Ser Val
100 105 110
Lys Gln Val Ser Ser Ala Glu Val Arg Ile Gly Pro Met Arg Leu Thr
115 120 125
Gln Asp Pro Ile Gln Val Leu Leu Ile Phe Ala Lys Glu Asp Ser Gln
130 135 140
Ser Asp Gly Phe Trp Trp Ala Cys Asp Arg Ala Gly Tyr Arg Cys Asn
145 150 155 160
Ile Ala Arg Thr Pro Glu Ser Ala Leu Glu Cys Phe Leu Asp Lys His
165 170 175
His Glu Ile Ile ValIle Asp His Arg Gln Thr Gln Asn Phe Asp Ala
180 185 190
Glu Ala Val Cys Arg Ser Ile Arg Ala Thr Asn Pro Ser Glu His Thr
195 200 205
Val Ile Leu Ala Val Val Ser Arg Val Ser Asp Asp His Glu Glu Ala
210 215 220
Ser Val Leu Pro Leu Leu His Ala Gly Phe Asn Arg Arg Phe Met Glu
225 230 235 240
Asn Ser Ser Ile Ile Ala Cys Tyr Asn Glu Leu Ile Gln Ile Glu His
245 250 255
Gly Glu Val Arg Ser Gln Phe Lys Leu Arg Ala Cys Asn Ser Val Phe
260 265 270
Thr Ala Leu Asp His Cys His Glu Ala Ile Glu Ile Thr Ser Asp Asp
275 280 285
His Val Ile Gln Tyr Val Asn Pro Ala Phe Glu Arg Met Met Gly Tyr
290 295 300
His Lys Gly Glu Leu Leu Gly Lys Glu Leu Ala Asp Leu Pro Lys Ser
305 310 315 320
Asp Lys Asn Arg Ala Asp Leu Leu Asp Thr Ile Asn Thr Cys Ile Lys
325 330 335
Lys Gly Lys Glu Trp Gln Gly Val Tyr Tyr Ala Arg Arg Lys Ser Gly
340 345 350
Asp Ser Ile Gln Gln His Val Lys Ile Thr Pro Val Ile Gly Gln Gly
355 360 365
Gly Lys Ile Arg Hi s Phe Val Ser Leu Lys Lys Leu Cys Cys Thr Thr
370 375 380
Asp Asn Asn Lys Gln Ile His Lys Ile His Arg Asp Ser Gly Asp Asn
385 390 395 400
Ser Gln Thr Glu Pro His Ser Phe Arg Tyr Lys Asn Arg Arg Lys Glu
405 4l0 4l5
Ser Ile Asp Val Lys Ser Ile Ser Ser Arg Gly Ser Asp Ala Pro Ser
420 425 430
Leu Gln Asn Arg Arg Tyr Pro Ser Met Ala Arg Ile His Ser Met Thr
435 440 445
Ile Glu Ala Pro Ile Thr Lys Val Ile Asn Ile Ile Asn Ala Ala Gln
450 455 460
Glu Asn Ser Pro Val Thr Val Ala Glu Ala Leu Asp Arg Val Leu Glu
465 470 475 480
Ile Leu Arg Thr Thr Glu Leu Tyr Ser Pro Gln Leu Gly Thr Lys Asp
485 490 495
Glu Asp Pro His Thr Ser Asp Leu Val Gly Gly Leu Met Thr Asp Gly
500 505 510
Leu Arg Arg Leu Ser Gly Asn Glu Tyr Val Phe Thr Lys Asn Val His
515 520 525
Gln Ser His Ser His Leu Ala Met Pro Ile Thr Ile Asn Asp Val Pro
530 535 540
Pro Cys Ile Ser Gln Leu Leu Asp Asn Glu Glu Ser Trp Asp Phe Asn
545 550 555 560
Ille Phe Glu Leu Glu Ala Ile Thr His Lys Arg Pro Leu Val Tyr Leu
565 570 575
Gly Leu Lys Val Phe Ser Arg Phe Gly Val Cys Glu Phe Leu Asn Cys
580 585 590
Ser Glu Thr Thr Leu Arg Ala Trp Phe Gln Val Ile Glu Ala Asn Tyr
595 600 605
His Ser Ser Asn Ala Tyr His Asn Ser Thr His Ala Ala Asp Val Leu
610 615 620
His Ala Thr Ala Phe Phe Leu Gly Lys Glu Arg Val Lys Gly Ser Leu
625 630 635 640
Asp Gln Leu Asp Glu Val Ala Ala Leu Ile Ala Ala Thr Val His Asp
645 650 655
Val Asp His Pro Gly Arg Thr Asn Ser Phe Leu Cys Asn Ala Gly Ser
660 665 670
Glu Leu Ala Val Leu Tyr Asn Asp Thr Ala Val Leu Glu Ser His His
675 680 685
Thr Ala Leu Ala Phe Gln Leu Thr Val Lys Asp Thr Lys Cys Asn Ile
690 695 700
Phe Lys Asn Ile Asp Arg Asn His Tyr Arg Thr Leu Arg Gln Ala Ile
705 710 715 720
Ile Asp Met Val Leu Ala Thr Glu Met Thr Lys His Phe Glu His Val
725 730 735
Asn Lys Phe Val Asn Ser Ile Asn Lys Pro Met Ala Ala Glu Ile Glu
740 745 750
Gly Ser Asp Cys Glu Cys Asn Pro Ala Gly Lys Asn Phe Pro Glu Asn
755 760 765
Gln Ile Leu Ile Lys Arg Met Met Ile Lys Cys Ala Asp Val Ala Asn
770 775 780
Pro Cys Arg Pro Leu Asp Leu Cys Ile Glu Trp Ala Gly Arg Ile Ser
785 790 795 800
Glu Glu Tyr Phe Ala Gln Thr Asp Glu Glu Lys Arg Gln Gly Leu Pro
805 810 815
Val Val Met Pro Val Phe Asp Arg Asn Thr Cys Ser Ile Pro Lys Ser
820 825 830
Gln Ile Ser Phe Ile Asp Tyr Phe Ile Thr Asp Met Phe Asp Ala Trp
835 840 845
Asp Ala Phe Ala His Leu Pro Ala Leu Met Gln His Leu Ala Asp Asn
850 855 860
Tyr Lys His Trp Lys Thr Leu Asp Asp Leu Lys Cys Lys Ser Leu Arg
865 870 875 880
Leu Pro Ser Asp Ser
885
<210>195
<211>427
<212>PRT
<213>人
<400>195
Met Phe Phe Thr Cys Gly Pro Asn Glu Ala Met Val Val Ser Gly Phe
1 5 10 15
Cys Arg Ser Pro Pro Val Met Val Ala Gly Gly Arg Val Phe Val Leu
20 25 30
Pro Cys Ile Gln Gln Ile Gln Arg Ile Ser Leu Asn Thr Leu Thr Leu
35 40 45
Asn Val Lys Ser Glu Lys Val Tyr Thr Arg His Gly Val Pro Ile Ser
50 55 60
Val Thr Gly Ile Ala Gln Val Lys Ile Gln Gly Gln Asn Lys Glu Met
65 70 75 80
Leu Ala Ala Ala Cys Gln Met Phe Leu Gly Lys Thr Glu Ala Glu Ile
85 90 95
Ala His Ile Ala Leu Glu Thr Leu Glu Gly His Gln Arg Ala Ile Met
100 105 110
Ala His Met Thr Val Glu Glu Ile Tyr Lys Asp Arg Gln Lys Phe Ser
115 120 125
Glu Gln Val Phe Lys Val Ala Ser Ser Asp Leu Val Asn Met Gly Ile
130 135 140
Ser Val Val Ser Tyr Thr Leu Lys Asp Ile His Asp Asp Gln Asp Tyr
145 150 155 160
Leu His Ser Leu Gly Lys Ala Arg Thr Ala Gln Val Gln Lys Asp Ala
165 170 175
Arg Ile Gly Glu Ala Glu Ala Lys Arg Asp Ala Gly Ile Arg Glu Ala
180 185 190
Lys Ala Lys Gln Glu Lys Val Ser Ala Gln Tyr Leu Ser Glu Ile Glu
195 200 205
Met Ala Lys Ala Gln Arg Asp Tyr Glu Leu Lys Lys Ala Ala Tyr Asp
210 215 220
Ile Glu Val Asn Thr Arg Arg Ala Gln Ala Asp Leu Ala Tyr Gln Leu
225 230 235 240
Gln Val Ala Lys Thr Lys Gln Gln Ile Glu Glu Gln Arg Val Gln Val
245 250 255
Gln Val Val Glu Arg Ala Gln Gln Val Ala Val Gln Glu Gln Glu Ile
260 265 270
Ala Arg Arg Glu Lys Glu Leu Glu Ala Arg Val Arg Lys Pro Ala Glu
275 280 285
Ala Glu Arg Tyr Lys Leu Glu Arg Leu Ala Glu Ala Glu Lys Ser Gln
290 295 300
Leu Ile Met Gln Ala Glu Ala Glu Ala Ala Ser Val Arg Met Arg Gly
305 310 315 320
Glu Ala Glu Ala Phe Ala Ile Gly Ala Arg Ala Arg Ala Glu Ala Glu
325 330 335
Gln Met Ala Lys Lys Ala Glu Ala Phe Gln Leu Tyr Gln Glu Ala Ala
340 345 350
Gln Leu Asp Met Leu Leu Glu Lys Leu Pro Gln Val Ala Glu Glu Ile
355 360 365
Ser Gly Pro Leu Thr Ser Ala Asn Lys Ile Thr Leu Val Ser Ser Gly
370 375 380
Ser Gly Thr Met Gly Ala Ala Lys Val Thr Gly Glu Val Leu Asp Ile
385 390 395 400
Leu Thr Arg Leu Pro Glu Ser Val Glu Arg Leu Thr Gly Val Ser Ile
405 410 415
Ser Gln Val Asn His Lys Pro Leu Arg Thr Ala
420 425
<210>196
<211>495
<212>PRT
<213>人
<400>196
Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly
1 5 10 15
Met Leu Val Ala Ser Cys Leu Gly Arg Leu Ser Trp Tyr Asp Pro Asp
20 25 30
Phe Gln Ala Arg Leu Thr Arg Ser Asn Ser Lys Cys Gln Gly Gln Leu
35 40 45
Glu Val Tyr Leu Lys Asp Gly Trp His Met Val Cys Ser Gln Ser Trp
50 55 60
Gly Arg Ser Ser Lys Gln Trp Glu Asp Pro Ser Gln Ala Ser Lys Val
65 70 75 80
Cys Gln Arg Leu Asn Cys Gly Val Pro Leu Ser Leu Gly Pro Phe Leu
85 90 95
Val Thr Tyr Thr Pro Gln Ser Ser Ile Ile Cys Tyr Gly Gln Leu Gly
100 105 110
Ser Phe Ser Asn Cys Ser His Ser Arg Asn Asp Met Cys His Ser Leu
115 120 125
Gly Leu Thr Cys Leu Glu Pro Gln Lys Thr Thr Pro Pro Thr Thr Arg
130 135 140
Pro Pro Pro Thr Thr Thr Pro Glu Pro Thr Ala Pro Pro Arg Leu Gln
145 150 155 160
Leu Val Ala Gln Ser Gly Gly Gln His Cys Ala Gly Val Val Glu Phe
165 170 175
Tyr Ser Gly Ser Leu Gly Gly Thr Ile Ser Tyr Glu Ala Gln Asp Lys
180 185 190
Thr Gln Asp Leu Glu Asn Phe Leu Cys Asn Asn Leu Gln Cys Gly Ser
195 200 205
Phe Leu Lys His Leu Pro Glu Thr Glu Ala Gly Arg Ala Gln Asp Pro
210 215 220
Gly Glu Pro Arg Glu His Gln Pro Leu Pro Ile Gln Trp Lys Ile Gln
225 230 235 240
Asn Ser Ser Cys Thr Ser Leu Glu His Cys Phe Arg Lys Ile Lys Pro
245 250 255
Gln Lys Ser Gly Arg Val Leu Ala Leu Leu Cys Ser Gly Phe Gln Pro
260 265 270
Lys Val Gln Ser Arg Leu Val Gly Gly Ser Ser Ile Cys Glu Gly Thr
275 280 285
Val Glu Val Arg Gln Gly Ala Gln Trp Ala Ala Leu Cys Asp Ser Ser
290 295 300
Ser Ala Arg Ser Ser Leu Arg Trp Glu Glu Val Cys Arg Glu Gln Gln
305 310 315 320
Cys Gly Ser Val Asn Ser Tyr Arg Val Leu Asp Ala Gly Asp Pro Thr
325 330 335
Ser Arg Gly Leu Phe Cys Pro His Gln Lys Leu Ser Gln Cys His Glu
340 345 350
Leu Trp Glu Arg Asn Ser Tyr Cys Lys Lys Val Phe Val Thr Cys Gln
355 360 365
Asp Pro Asn Pro Ala Gly Leu Ala Ala Gly Thr Val Ala Ser Ile Ile
370 375 380
Leu Ala Leu Val Leu Leu Val Val Leu Leu Val Val Cys Gly Pro Leu
385 390 395 400
Ala Tyr Lys Lys Leu Val Lys Lys Phe Arg Gln Lys Lys Gln Arg Gln
405 410 415
Trp Ile Gly Pro Thr Gly Met Asn Gln Asn Met Ser Phe His Arg Asn
420 425 430
His Thr Ala Thr Val Arg Ser His Ala Glu Asn Pro Thr Ala Ser His
435 440 445
Val Asp Asn Glu Tyr Ser Gln Pro Pro Arg Asn Sar Arg Leu Ser Ala
450 455 460
Tyr Pro Ala Leu Glu Gly Val Leu His Arg Ser Ser Met Gln Pro Asp
465 470 475 480
Asn Ser Ser Asp Ser Asp Tyr Asp Leu His Gly Ala Gln Arg Leu
485 490 495
<210>197
<211>540
<212>PRT
<213>人
<400>197
Met Gly Thr Thr Ala Arg Ala Ala Leu Val Leu Thr Tyr Leu Ala yal
1 5 10 15
Ala Ser Ala Ala Ser Glu Gly Gly Phe Thr Ala Thr Gly Gln Arg Gln
20 25 30
Leu Arg Pro Glu His Phe Gln Glu Val Gly Tyr Ala Ala Pro Pro Ser
35 40 45
Pro Pro Leu Ser Arg Ser Leu Pro Met Asp His Pro Asp Ser Ser Gln
50 55 60
His Gly Pro Pro Phe Glu Gly Gln Ser Gln Val Gln Pro Pro Pro Ser
65 70 75 80
Gln Glu Ala Thr Pro Leu Gln Gln Glu Lys Leu Leu Pro Ala Gln Leu
85 90 95
Pro Ala Glu Lys Glu Val Gly Pro Pro Leu Pro Gln Glu Ala Val Pro
100 105 110
Leu Gln Lys Glu Leu Pro Ser Leu Gln His Pro Asn Glu Gln Lys Glu
115 120 125
Gly Thr Pro Ala Pro Phe Gly Asp Gln Ser His Pro Glu Pro Glu Ser
130 135 140
Trp Asn Ala Ala Gln His Cys Gln Gln Asp Arg Ser Gln Gly Gly Trp
145 150 155 160
Gly His Arg Leu Asp Gly Phe Pro Pro Gly Arg Pro Ser Pro Asp Asn
165 170 175
Leu Asn Gln Ile Cys Leu Pro Asn Arg Gln His Val Val Tyr Gly Pro
180 185 190
Trp Asn Leu Pro Gln Ser Ser Tyr Ser His Leu Thr Arg Gln Gly Glu
195 200 205
Thr Leu Asn Phe Leu Glu Ile Gly Tyr Ser Arg Cys Cys His Cys Arg
210 215 220
Ser His Thr Asn Arg Leu Glu Cys Ala Lys Leu Val Trp Glu Glu Ala
225 230 235 240
Met Ser Arg Phe Cys Glu Ala Glu Phe Ser Val Lys Thr Arg Pro His
245 250 255
Trp Cys Cys Thr Arg Gln Gly Glu Ala Arg Phe Ser Cys Phe Gln Glu
260 265 270
Glu Ala Pro Gln Pro His Tyr Gln Leu Arg Ala Cys Pro Ser His Gln
275 280 285
Pro Asp Ile Ser Ser Gly Leu Glu Leu Pro Phe Pro Pro Gly Val Pro
290 295 300
Thr Leu Asp Asn Ile Lys Asn Ile Cys His Leu Arg Arg Phe Arg Ser
305 310 315 320
Val Pro Arg Asn Leu Pro Ala Thr Asp Pro Leu Gln Arg Glu Leu Leu
325 330 335
Ala Leu Ile Gln Leu Glu Arg Glu Phe Gln Arg Cys Cys Arg Gln Gly
340 345 350
Asn Asn His Thr Cys Thr Trp Lys Ala Trp Glu Asp Thr Leu Asp Lys
355 360 365
Tyr Cys Asp Arg Glu Tyr Ala Val Lys Thr His His His Leu Cys Cys
370 375 380
Arg His Pro Pro Ser Pro Thr Arg Asp Glu Cys Phe Ala Arg Arg Ala
385 390 395 400
Pro Tyr Pro Asn Tyr Asp Arg Asp Ile Leu Thr Ile Asp Ile Gly Arg
405 410 415
Val Thr Pro Asn Leu Met Gly His Leu Cys Gly Asn Gln Arg Val Leu
420 425 430
Thr Lys His Lys His Ile Pro Gly Leu Ile His Asn Met Thr Ala Arg
435 440 445
Cys Cys Asp Leu Pro Phe Pro Glu Gln Ala Cys Cys Ala Glu Glu Glu
450 455 460
Lys Leu Thr Phe Ile Asn Asp Leu Cys Gly Pro Arg Arg Asn Ile Trp
465 470 475 480
Arg Asp Pro Ala Leu Cys Cys Tyr Leu Ser Pro Gly Asp Glu Gln Val
485 490 495
Asn Cys Phe Asn Ile Asn Tyr Leu Arg Asn Val Ala Leu Val Ser Gly
500 505 510
Asp Thr Glu Asn Ala Lys Gly Gln Gly Glu Gln Gly Ser Thr Gly Gly
515 520 525
Thr Asn Ile Ser Ser Thr Ser Glu Pro Lys Glu Glu
530 535 540
1.肾癌相关标记物
1.1.肾癌相关靶核酸
作为在使用本发明的组合物、试剂盒或DNA芯片检测、确定或预 测肾癌的存在及转移、预测肾癌患者预后、及确定肾癌转移细胞的存 在或不存在时使用的肾癌转移关联标记物的靶核酸，包括例如含有序 列号1～50表示的碱基序列的人基因(即、分别为PABPN1、PINK1、 TFF2、EIF3S9、MAX、MLL4、CACNB2、ZMYND11、BAT2、NRBP、 MCM3AP、COL4A1、MKNK1、BBC3、FLJ10359、DPT、C10orf76、 DIA1、PBK、PRKD2、KRT19、FLJ23436、NPHS2、C3orf14、AGTR2、 HTR1F、KIF3B、DCN、STK22C、DKFZp566C0424、CNR1、HOMER3、 GPR2、FLJ12442、XLKD1，CASKIN2、COL5A2、BRD3、ATP6V0A4、 PRODH2、EPHB2、LYAR、COX6B、PRH1、LAPTM5、RPS6KA4、 GCC2、FGF2、MMP14及ERBB2)、它们的同源物、它们的转录产物 或cDNA、或者它们的变异体或衍生物。此处，基因、同源物、转录 产物、cDNA、变异体及衍生物如上述定义所示。理想的靶核酸为含 有序列号1～50表示的碱基序列的人基因、它们的转录产物或cDNA， 较理想为该转录产物或cDNA。
本发明中，成为肾癌患者预后预测的靶标及/或肾癌转移预测的 靶标的上述基因，均为与来自预后良好的患者的肾癌组织相比在来自 预后不良的患者的肾癌组织中该基因的表达水平显著变化(即、增加 或降低)的基因。表1给出各基因的Ensemble Gene ID及GenBank登录 号。所示的基因由识别来自预后良好的患者的肾癌组织的基因、识别 来自预后不良的患者的肾癌组织的基因构成。
[表1]
序 列 号 Ensemble Gene ID GenBank 登录号 基因名 序 列 号 Ensemble Gene ID GenBank 登录号 基因名 1 ENSG0000010 0836 NM_004643 PABPN1 26 ENSG00000179097 NM_000866 HTR1F 2 ENSG0000018 0056 NM_032409 PINK1 27 ENSG00000101350 NM_004798 KIF3B 3 ENSG0000016 0181 NM_005423 TFF2 28 ENSG00000011465 NM_133506 DCN 4 ENSG0000010 6263 NM_003751 EIF3S9 29 ENSG00000162526 NM_052841 STK22C 5 ENSG0000012 5952 NM_002382 MAX 30 ENSG00000055070 BX640985 DKFZp566C04 24 6 ENSG0000010 5663 NM_014727 MLL4 31 ENSG00000118432 NM_016083 CNR1 7 ENSG0000016 5995 NM_000724 CACNB2 32 ENSG00000051128 NM_004838 HOMER3 8 ENSG0000001 5171 NM_006624 ZMYND1 1 33 ENSG00000177032 NM_016602 GPR2 9 ENSG0000011 1960 NM_004638 BAT2 34 ENSG00000168268 NM_022908 FLJ12442 10 ENSG0000011 5216 NM_013392 NRBP 35 ENSG00000133800 NM_006691 XLKD1 11 ENSG0000016 0294 NM_003906 MCM3AP 36 ENSG00000177303 NM_020753 CASKIN2 12 ENSG0000013 9825 NM_001845 COL4Al 37 ENSG00000179877 NM_000393 COL5A2 13 ENSG0000007 9277 NM_003684 MKNK1 38 ENSG00000169925 NM_007371 BRD3 14 ENSG0000010 5327 NM_014417 BBC3 39 ENSG00000105929 NM_020632 ATP6V0A4 15 ENSG0000011 9285 NM_018072 FLJ10359 40 ENSG00000161270 NM_021232 PRODH2 16 ENSG0000014 3196 NM_001937 DPT 41 ENSG00000133216 NM_004442 EPHB2 17 ENSG0000012 0029 NM_024541 C10orf76 42 ENSG00000145220 NM_017816 LYAR 18 ENSG0000010 0243 NM_007326 DIA1 43 ENSG00000126267 NM_001863 COX6B 19 ENSG0000016 8078 NM_018492 PBK 44 ENSG00000176621 NM_006250 PRH2 20 ENSG0000010 5287 NM_016457 PRKD2 45 ENSG00000162511 NM_006762 LAPTM5 21 ENSG0000017 1345 NM_002276 KRT19 46 ENSG00000162302 NM_003942 RPS6KA4 22 ENSG0000016 9957 NM_024671 FLJ23436 47 ENSG00000144055 NM_181453， NM_014635 GCC2 23 ENSG0000011 6218 NM_014625 NPHS2 48 ENSG00000138685 NM_002006 FGF2 24 ENSG0000011 4405 NM_020685 C3orf14 49 ENSG00000157227 NM_004995 MMP14 25 ENSG0000018 0772 NM_000686 AGTR2 50 ENSG00000141736 NM_004448 ERBB2
第1靶核酸为，PABPN1基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第2靶核酸为，PINK1基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第3靶核酸为，TFF2基因、其同源物、其转录产物或cDNA、或者 其变异体或衍生物。
第4靶核酸为，EIF3S9基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第5靶核酸为，MAX基因、其同源物、其转录产物或cDNA、或者 其变异体或衍生物。
第6靶核酸为，MLL4基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第7靶核酸为，CACNB2基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第8靶核酸为，ZMYND11基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第9靶核酸为，BAT2基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第10靶核酸为，NRBP基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第11靶核酸为，MCM3AP基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第12靶核酸为，COL4A1基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第13靶核酸为，MKNK1基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第14靶核酸为，BBC3基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第15靶核酸为，FLJ10359基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第16靶核酸为，DPT基因、其同源物、其转录产物或cDNA、或者 其变异体或衍生物。
第17靶核酸为，C10orf76基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第18靶核酸为，DIA1基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第19靶核酸为，PBK基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第20靶核酸为，PRKD2基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第21靶核酸为，KRT19基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第22靶核酸为，FLJ23436基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第23靶核酸为，NPHS2基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第24靶核酸为，C3orf14基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第25靶核酸为，AGTR2基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第26靶核酸为，HTR1F基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第27靶核酸为，KIF3B基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第28靶核酸为，DCN基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第29靶核酸为，STK22C基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第30靶核酸为，DKFZp566C0424基因、其同源物、其转录产物或 cDNA、或者其变异体或衍生物。
第31靶核酸为，CNR1基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第32靶核酸为，HOMER3基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第33靶核酸为，GPR2基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第34靶核酸为，FLJ12442基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第35靶核酸为，XLKD1基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第36靶核酸为，CASKIN2基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第37靶核酸为，COL5A2基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第38靶核酸为，BRD3基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第39靶核酸为，ATP6V0A4基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第40靶核酸为，PRODH2基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第41靶核酸为，EPHB2基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第42靶核酸为，LYAR基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第43靶核酸为，COX6B基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第44靶核酸为，PRH1基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第45靶核酸为，LAPTM5基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第46靶核酸为，RPS6KA4基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第47靶核酸为，GCC2基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第48靶核酸为，FGF2基因、其同源物、其转录产物或cDNA、或 者其变异体或衍生物。
第49靶核酸为，MMP14基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
第50靶核酸为，ERBB2基因、其同源物、其转录产物或cDNA、 或者其变异体或衍生物。
1.2肾癌相关靶多肽(1)
作为在使用本发明的组合物或试剂盒检测、确定或预测肾癌的存 在及转移、预测肾癌患者预后、及确定肾癌转移细胞的存在或不存在 时使用的肾癌关联标记物的靶多肽，包括由下述基因编码的多肽，例 如，含有序列号101～150表示的氨基酸序列的人多肽、其同源物、或 者其变异体或衍生物，所述基因为PABPN1、PINK1、TFF2、EIF3S9、 MAX、MLL4、CACNB2、ZMYND11、BAT2、NRBP、MCM3AP、 COL4A1、MKNK1、BBC3、FLJ10359、DPT、C10orf76、DIA1、PBK、 PRKD2、KRT19、FLJ23436、NPHS2、C3orf14、AGTR2、HTR1F、 KIF3B、DCN、STK22C、DKFZp566C0424、CNR1、HOMER3、GPR2、 FLJ12442、XLKD1、CASKIN2、COL5A2、BRD3、ATP6V0A4、PRODH2、 EPHB2、LYAR、COX6B、PRH1、LAPTM5、RPS6KA4、GCC2、FGF2、 MMP14及ERBB2基因。此处，多肽、同源物、变异体及衍生物如上 述定义所示。理想的靶多肽为含有序列号101～110、112～120、122～ 147表示的氨基酸序列的人多肽。
本发明中成为肾癌转移预测及/或肾癌患者预后预测的靶标的 上述多肽的特征在于，与对应的基因及其转录产物的表达量相同，都 为与来自预后良好的肾癌患者的肾癌组织相比在来自预后不良的肾 癌患者的肾癌组织中其表达量显著变化(即，增加或降低)的多肽， 或血液中该多肽的水平与预后良好的肾癌患者相比在预后不良的肾 癌患者中显著变化(即，增加或降低)。
1.3肾癌相关靶多肽(2)
作为在使用本发明的组合物或试剂盒体外检测肾癌时使用的肾 癌标记物的其它肾癌相关靶多肽，是含有序列号151～197、优选序列 号151、153、155～160、序列号161～190表示的氨基酸序列的多肽、 其变异体或其片段。
本发明的序列号151～160、191、序列号161～190、192～197的 多肽与其基因名及蛋白质序号(GenBank登录名及登录号)、及其特 性一起分别示于下述表2、表3。上述多肽在肾癌患者血浆中被特异性 检测出，在健康人的血浆中未被检测出、或未达到能够检测的水平。
[表2]
序列号 基因名 蛋白质序号 特性 151 AAK2 P54646 AMP激酶2 152 SLK4 Q8IW52 SLIT及NTRK样蛋白4前体 153 SP4L Q8TC36 精子相关抗原4样蛋白质(睾丸及精子形成 相关基因4蛋白质) 154 C5P1 Q96SZ6 CDK5调节亚单位相关蛋白1(CDK5激活结 合蛋白质C42)(CGI-05) 155 SI8A Q92185 α-N-乙酰-神经氨酸苷α-2，8-唾液 酸转移酶(EC 2.4.99.8)(神经节苷脂GD3 合酶) 156 KAP2 P13861 cAMP依赖性蛋白激酶II型-α调节链 157 F262 060825 6-磷酸果糖-2-激酶/果糖-2，6-二磷 酸酶2(6PF-2-K/Fru-2，6-P2ASE心 脏型同工酶)(PFK-2/FBPase-2)[6 -磷酸果糖-2-激酶〔EC 2.7.1.105)； 含有果糖-2，6-二磷酸酶(EC3.1.3.46)] 158 TCPH Q99832 T-复合蛋白1，eta亚单位(TCP-1-eta) (CCT-eta)(HIV-1Nef相互作用蛋白 质) 159 GB11 P29992 鸟嘌呤核苷酸结合蛋白G(y)，α亚单位(α -11) 160 CT67 Q9H4Z3 蛋白C20orf67 191 CEGT Q16739 神经酰胺葡糖基转移酶(EC 2.4.1.80)(葡 糖神经酰胺合成酶)(GCS)(UDP-葡 萄糖)
[表3]
序列号 基因名 蛋白质序号 特性 161 AMIIR2 Q16671 Anti-muellerian激素II型受体前体(EC 2.7.1.37)(AMH II型受体)(MIS II型受体)(MISRII)(MRII) 162 APOL3 O95236 载脂蛋白L3(载脂蛋白L-III)(ApoL-III)(TNF -诱导性蛋白质CG12-1) 163 DEDD2 Q8WXF8 DNA结合的含有死亡效应结构域的蛋白2(含DED的蛋 白质FLAME-3) 164 HEXB P07686 β-氨基己糖苷酶β链前体(EC 3.2.1.52)(N-乙酰-β- 氨基葡萄糖苷酶) 165 HNRPK P61978 异质性胞核核糖核蛋白(hnRNP K) 166 KPNA1 P52294 输入蛋白(Importin)α-1亚单位(核周蛋白 (karyopherin)α-1亚单位)(SRP1-β)(RAG组蛋 白2)，(核蛋白相互作用蛋白-1)(NPI-1) 167 LASP1 Q14847 LIM及SH3结构域蛋白1(LASP-1)(MLN 50) 168 LIAS O43766 硫辛酸合成酶，线粒体前体(mitochondrial precursor) (Lip-syn)(硫辛酸合成酶)(HUSSY-01) 169 MAGEC3 Q8TD91 黑色素瘤相关抗原C3(MAGE-C3抗原) 170 NFATC4 Q14934 活化T细胞的核因子，细胞质4(T细胞转录因子 NFAT3)(NF-ATc4)(NF-AT3) 171 OLFM3 Q96PB7 Noelin 3前体(嗅介蛋白3)(optimedin)(UNQ1924 /PRO4399) 172 POLR3F Q9H1D9 DNA依赖性RNA聚合酶III 39kDa多肽(EC 2.7.7.6) 173 PPP3CB NP 066955 丝氨酸/苏氨酸蛋白磷酸酶2B催化剂亚单位，β异型 (EC 3.1.3.16) 174 SF1 Q15637 剪接因子1(锌指蛋白162)(转录因子ZFM1) 175 SLC24A2 Q9UI40 钠/钾/钙交换体2前体(Na(+)/K(+)/Ca(2 +)-交换蛋白2) 176 SLC26A4 O43511 潘蛋白(Pendrin)(钠非依赖性氯/碘转运蛋白) 177 SLCO1A2 P46721 溶质运载有机阴离子转运蛋白家族成员1A2 178 TPM2 P07951 原肌球蛋白β链(原肌球蛋白2)(β-原肌球蛋白) 179 UCHL5 Q9Y5K5 泛素羧基末端水解酶同工酶L5(EC 3.4.19.12)(UCH -L5) 180 UGT8 Q16880 2-羟酰基鞘氨醇1-β-半乳糖基转移酶前体(EC 2.4.1.45)(UDP-半乳糖神经酰胺转移酶) 181 ZNF140 P52738 锌指蛋白140 182 ZNF274 Q96GC6 锌指蛋白274(锌指蛋白SP2114)(锌指蛋白HFB101) 183 MID2 Q9UJV3 Midline 2 184 LIPE Q05469 脂酶，激素敏感性 185 HDAC6 Q9UBN7 组蛋白去乙酰化酶6 186 ACO2 Q99798 乌头酸酶(Aconitase)2，线粒体 187 APLP1 P51693 淀粉状蛋白β(A4)前体样蛋白1 188 NUMB P49757 Numb同源物(果蝇)
189 ARHGEF7 Q14155 Rho鸟嘌呤核苷酸交换因子(GEF)7 190 GNAQ P50148 鸟苷酸结合蛋白质(G蛋白质)，q多肽 191 MMP2 P08253 72kDa IV型胶原酶前体(EC 3.4.24.24)(72kDa明胶 酶) 192 TNFRSF7 P26842 肿瘤坏死因子受体超家族成员7前体(CD27L受体) 193 PDE8B O95263 高亲和性cAMP特异性及IBMX非敏感性3’，5’-环磷 酸二酯酶8B 194 FLOT1 O75955 阀蛋白1(Flotillin 1) 195 CD5 P06127 T细胞表面糖蛋白CD5[前体] 196 ECM1 Q16610 细胞外基质蛋白1
在本发明中，用于检测肾癌的上述靶多肽均具有以下特征：该多 肽在肾癌患者的血液等生物试样中的水平与健康人相比，患有肾癌的 受试者中的多肽水平显著或特别高。
2.肾癌诊断用探针
根据本发明，用于检测、确定或预测肾癌的存在及/或转移的探针、 或用于预测受试者术后预后的探针选自下述I组及/或II组：
I组：由以下(a)～(e)构成的多核苷酸，
(a)由序列号1～10、12～20、22～47表示的碱基序列构成的多 核苷酸、其变异体、或其含有15个以上连续碱基的片段，
(b)含有序列号1～10、12～20、22～47表示的碱基序列的多核 苷酸，
(c)由与序列号1～10、12～20、22～47表示的碱基序列互补的 碱基序列构成的多核苷酸、其变异体、或其含有15个以上连续碱基的 片段，
(d)含有与序列号1～10、12～20、22～47表示的碱基序列互补 的碱基序列的多核苷酸，及
(e)与上述(a)～(d)中任一个多核苷酸在严格条件下杂交的 多核苷酸、或其含有15个以上连续碱基的片段，
II组：由(f)～(h)构成的抗体、其片段或者其化学修饰衍生物，
(f)与含有由序列号1～10、12～20、22～47表示的碱基序列编 码的氨基酸序列的多肽、或含有序列号101～110、112～120、122～ 147表示的氨基酸序列的多肽、其变异体、或者其片段中的至少1个特 异性结合的抗体、其片段或者其化学修饰衍生物，
(g)与含有序列号151、153、155～160表示的氨基酸序列的多 肽、其变异体、或者其片段中的至少1个特异性结合的抗体、其片段 或者其化学修饰衍生物，及
(h)与含有序列号161～190表示的氨基酸序列的多肽、其变异 体、或者其片段中的至少1个特异性结合的抗体、其片段或者其化学 修饰衍生物。
上述探针均能与上述1.1至1.3中记载的肾癌相关标记物中的任一 种结合，能够用于检测、确定或预测肾癌的存在或转移。例如，通过 上述I组及II组(f)的各探针，能够检测、确定或预测肾癌的存在或 转移。另外，通过上述II组(g)、(h)的各探针，能够检测、确定 或预测肾癌的存在。
本发明中，核酸探针包括DNA或RNA，另一方面，抗体探针包括 多克隆抗体、单克隆抗体、它们的抗体片段、合成抗体、重组抗体、 多重特异性抗体、单链抗体等。
本次，本发明人等首次发现上述I组及/或II组所示的探针能够用 于肾癌存在及/或转移的检测、确定或预测。
3.用于肾癌诊断及/或肾癌预后预测或转移预测的组合物
3.1核酸组合物
使用本发明的组合物或试剂盒检测、确定或预测肾癌的存在及转 移、预测肾癌患者预后、及确定肾癌转移细胞的存在或不存在时使用 的核酸组合物，含有上述2中的I组中记载的1种或2种以上探针，能 够定性及/或定量地测定作为用于肾癌预后预测或肾癌转移预测的靶 核酸的以下物质的存在、表达量或存在量，所述物质为来自人的 PABPN1、PINK1、TFF2、EIF3S9、MAX、MLL4、CACNB2、ZMYND11、 BAT2、NRBP、MCM3AP、COL4A1、MKNK1、BBC3、FLJ10359、 DPT、C10orf76、DIA1、PBK、PRKD2、KRT19、FLJ23436、NPHS2、 C3orf14、AGTR2、HTR1F、KIF3B、DCN、STK22C、DKFZp566C0424、 CNR1、HOMER3、GPR2、FLJ12442、XLKD1、CASKIN2、COL5A2、 BRD3、ATP6V0A4、PRODH2、EPHB2、LYAR、COX6B、PRH1、 LAPTM5、RPS6KA4、GCC2、FGF2、MMP14及ERBB2基因、其同源 物、其转录产物或cDNA、或其变异体或衍生物。
上述靶核酸在来自预后不良的肾癌患者的肾癌组织中的表达水 平，与来自预后良好的肾癌患者的肾癌组织相比，发生显著变化(即、 增加或降低)。因此，本发明的组合物能够有效地用于测定来自预后 良好的肾癌患者的肾癌组织中和来自预后不良的肾癌患者的肾癌组 织中的靶核酸的表达水平，并对其进行比较。
本发明中能使用的组合物包括选自下述多核苷酸组的1种或多种 多核苷酸的组合，所述多核苷酸组为患有肾癌的患者的生物组织中含 有序列号1～50表示的碱基序列的多核苷酸组及其互补多核苷酸组；在 严格条件下分别与DNA杂交的多核苷酸组及其互补多核苷酸组，所述 DNA由与上述碱基序列互补的碱基序列构成；及含有上述多核苷酸组 的碱基序列中15个以上连续碱基的多核苷酸组。
具体而言，本发明的组合物可以含有以下1种或多种多核苷酸或 其片段。
(1)由序列号1～50表示的碱基序列构成的多核苷酸组、其变异 体、或其含有15个以上连续碱基的片段。
(2)含有序列号1～50表示的碱基序列的多核苷酸组。
(3)由序列号1～10、12～20、22～47表示的碱基序列构成的多 核苷酸组、其变异体、或其含有15个以上连续碱基的片段。
(4)含有序列号1～10、12～20、22～47表示的碱基序列的多核 苷酸组。
(5)由与序列号1～10、12～20、22～47表示的碱基序列互补的 碱基序列构成的多核苷酸组、其变异体、或其含有15个以上连续碱基 的片段。
(6)含有与序列号1～10、12～20、22～47表示的碱基序列互补 的碱基序列的多核苷酸组。
(7)与下述DNA在严格条件下杂交的多核苷酸组、或其含有15 个以上连续碱基的片段，所述DNA由与序列号1～10、12～20、22～ 47表示的各碱基序列互补的碱基序列构成。
(8)与由序列号1～10、12～20、22～47表示的各碱基序列构成 的DNA在严格条件下杂交的多核苷酸组、或其含有15个以上连续碱基 的片段。
(9)由序列号11、21、48～50表示的碱基序列构成的多核苷酸 组、其变异体、或其含有15个以上连续碱基的片段。
(10)含有序列号11、21、48～50表示的碱基序列的多核苷酸组。
(11)由与序列号11、21、48～50表示的碱基序列互补的碱基序 列构成的多核苷酸组、其变异体、或其含有15个以上连续碱基的片段。
(12)含有与序列号11、21、48～50表示的碱基序列互补的碱基 序列的多核苷酸组。
(13)与下述DNA在严格条件下杂交的多核苷酸组、或其含有15 个以上连续碱基的片段，所述DNA由与序列号11、21、48～50表示的 各碱基序列互补的碱基序列构成。
(14)与由序列号11、21、48～50表示的各碱基序列构成的DNA 在严格条件下杂交的多核苷酸组、或其含有15个以上连续碱基的片 段。
上述(1)～(14)的多核苷酸的片段可以含有各多核苷酸的碱 基序列中的例如下述范围的连续碱基数，但并不限定于此，所述范围 包括15～序列的全部碱基数、15～5000个碱基、15～4500个碱基、15～ 4000个碱基、15～3500个碱基、15～3000个碱基、15～2500个碱基、 15～2000个碱基、15～1500个碱基、15～1000个碱基、15～900个碱 基、15～800个碱基、15～700个碱基、15～600个碱基、15～500个碱 基、15～400个碱基、15～300个碱基、15～250个碱基、15～200个碱 基、15～150个碱基、15～140个碱基、15～130个碱基、15～120个碱 基、15～110个碱基、15～100个碱基、15～90个碱基、15～80个碱基、 15～70个碱基、15～60个碱基、15～50个碱基、15～40个碱基、15～ 30个碱基或15～25个碱基；25～序列的全部碱基数、25～1000个碱基、 25～900个碱基、25～800个碱基、25～700个碱基、25～600个碱基、 25～500个碱基、25～400个碱基、25～300个碱基、25～250个碱基、 25～200个碱基、25～150个碱基、25～140个碱基、25～130个碱基、 25～120个碱基、25～110个碱基、25～100个碱基、25～90个碱基、 25～80个碱基、25～70个碱基、25～60个碱基、25～50个碱基或25～ 40个碱基；50～序列的全部碱基数、50～1000个碱基、50～900个碱 基、50～800个碱基、50～700个碱基、50～600个碱基、50～500个碱 基、50～400个碱基、50～300个碱基、50～250个碱基、50～200个碱 基、50～150个碱基、50～140个碱基、50～130个碱基、50～120个碱 基、50～110个碱基、50～100个碱基、50～90个碱基、50～80个碱基、 50～70个碱基或50～60个碱基；60～序列的全部碱基数、60～1000个 碱基、60～900个碱基、60～800个碱基、60～700个碱基、60～600个 碱基、60～500个碱基、60～400个碱基、60～300个碱基、60～250个 碱基、60～200个碱基、60～150个碱基、60～140个碱基、60～130个 碱基、60～120个碱基、60～110个碱基、60～100个碱基、60～90个 碱基、60～80个碱基或60～70个碱基等。
根据本发明的实施方案，含有序列号1～10、12～20、22～47表 示的碱基序列的多核苷酸的片段，优选分别含有序列号51～60、62～ 70、72～97表示的碱基序列或其互补的序列、或者其连续15个碱基以 上的部分序列。
本发明的组合物中例如含有以下多核苷酸。
(1)序列号1～10、12～20、22～47表示的碱基序列或其互补序 列的各序列中，含有15个以上连续碱基的多核苷酸。
(2)序列号1～10、12～20、22～47表示的碱基序列或其互补序 列的各序列中，含有60个以上连续碱基的多核苷酸。
(3)序列号11、21、48～50表示的碱基序列或其互补序列的各 序列中，含有15个以上连续碱基的多核苷酸。
(4)序列号11、21、48～50表示的碱基序列或其互补序列的各 序列中，含有60个以上连续碱基的多核苷酸。
(5)序列号1～10、12～20、22～47表示的碱基序列中，分别含 有序列号51～60、62～70、72～97表示的碱基序列、且含有60个以上 连续碱基的多核苷酸。
(6)与序列号1～10、12～20、22～47表示的碱基序列互补的序 列中，分别含有与序列号51～60、62～70、72～97表示的碱基序列互 补的序列、且含有60个以上连续碱基的多核苷酸。
(7)序列号11、21、48～50表示的碱基序列中，分别含有序列 号61、71、98～100表示的碱基序列、且含有60个以上连续碱基的多 核苷酸。
(8)与序列号11、21、48～50表示的碱基序列互补的序列中， 分别含有与序列号61、71、98～100表示的碱基序列互补的序列、且 含有60个以上连续碱基的多核苷酸。
本发明中使用的上述多核苷酸或其片段均可以为DNA也可以为 RNA。
构成本发明组合物的多核苷酸，可以使用DNA重组技术、PCR法、 采用DNA/RNA自动合成仪的方法等常规技术进行制作。
DNA重组技术及PCR法，例如可以使用Ausubel等，Current Protocols in Molecular Biology，John Willey &Sons，US(1993)； Sambrook等，Molecular Cloning A Laboratory Manual，Cold Spring Harbor Laboratory Press，US(1989)等中记载的技术。
来自人的PABPN1、PINK1、TFF2、EIF3S9、MAX、MLL4、 CACNB2、ZMYND11、BAT2、NRBP、MCM3AP、COL4A1、MKNK1、 BBC3、FLJ10359、DPT、C10orf76、DIA1、PBK、PRKD2、KRT19、 FLJ23436、NPHS2、C3orf14、AGTR2、HTR1F、KIF3B、DCN、STK22C、 DKFZp566C0424、CNR1、HOMER3、GPR2、FLJ12442、XLKD1、 CASKIN2、COL5A2、BRD3、ATP6V0A4、PRODH2、EPHB2、LYAR、 COX6B、PRH1、LAPTM5、RPS6KA4、GCC2、FGF2、MMP14及ERBB2 是公知的，如上所述，其获得方法也是已知的。所以，可以通过克隆 上述基因制备作为本发明的组合物的多核苷酸。
构成本发明的组合物的多核苷酸可以使用DNA自动合成装置化 学合成得到。通常可以使用亚磷酰胺法进行合成，可以利用该方法自 动合成至多约100个碱基的单链DNA。DNA自动合成装置可以从例 如Polygen公司、ABI公司、Applied BioSystems公司等购买。
本发明的多核苷酸也可以通过cDNA克隆法制备。可以从表达作 为本发明中的靶标的上述基因的肾组织等生物组织中提取总RNA，将 该总RNA用寡聚dT纤维素柱处理得到聚A(+)RNA，通过RT-PCR 法由该聚A(+)RNA制备cDNA库，通过杂交筛选、表达筛选、抗体 筛选等进行筛选，从该cDNA库得到目标cDNA克隆。可以根据需要， 利用PCR法扩增cDNA克隆。可以基于序列号1～50表示的碱基序列， 从15～100个连续碱基序列中选择并合成探针或引物。例如在 Sambrook，J.&Russel，D.著、Molecular Cloning，A LABORATORY MANUAL、Cold Spring Harbor Laboratory Press、2001年1月15日出版、 的第1卷7.42～7.45、第2卷8.9～8.17中记载了cDNA克隆技术。
3.2抗体组合物
本发明的组合物可以含有上述2中的II组中记载的抗体、其片段或 化学修饰衍生物作为肾癌诊断用探针。上述组合物对于体外检测、确 定或预测患有肾癌的受试者的肾癌存在及/或转移是有用的。此处， 转移的预测可以推导出受试者术后的预后良好、不良的预测结果。
(A)本发明的抗体组合物的第1例是含有针对下述多肽的1种或 多种抗体、该抗体的片段、或其化学修饰衍生物的组合物，所述多肽 具有上述II组(f)中记载的序列号101～110、112～120、122～147表 示的氨基酸序列。
本发明的组合物中可以进一步含有针对下述多肽、其变异体或其 片段的1种或多种抗体、该抗体的片段或化学修饰衍生物，所述多肽 具有序列号111、121、148～150表示的氨基酸序列。通过并用上述抗 体，可以提高预后预测的准确度。
即，根据本发明，为了检测作为肾癌预后预测用或肾癌转移标记 物的由PABPN1、PINK1、TFF2、EIF3S9、MAX、MLL4、CACNB2、 ZMYND11、BAT2、NRBP、MCM3AP、COL4A1、MKNK1、BBC3、 FLJ10359、DPT、C10orf76、DIA1、PBK、PRKD2、KRT19、FLJ23436、 NPHS2、C3orf14、AGTR2、HTR1F、KIF3B、DCN、STK22C、 DKFZp566C0424、CNR1、HOMER3、GPR2、FLJ12442、XLKD1、 CASKIN2、COL5A2、BRD3、ATP6V0A4、PRODH2、EPHB2、LYAR、 COX6B、PRH1、LAPTM5、RPS6KA4、GCC2、FGF2、MMP14及ERBB2 基因编码的多肽、其同源物、或其变异体或衍生物，能够组合使用1 个或多个、优选2个以上针对上述多肽的抗体。
(B)本发明的抗体组合物的第2例是含有针对下述多肽的1种或 多种抗体、该抗体的片段、或其化学修饰衍生物的组合物，所述多肽 含有上述II组(g)、(h)分别记载的序列号151～160、191、序列号 161～190、192～197表示的氨基酸序列。
上述多肽由表1、表2及表3所述的基因编码。各基因的碱基序列 可以通过登录NCBI主页根据表中所示的基因名容易地获得。
上述多肽可以利用DNA重组技术得到。例如，可以将如上所述得 到的cDNA克隆整合到表达载体中，通过培养由该载体转化或转染的 原核或真核宿主细胞，从该细胞或培养上清液中得到上述多肽。载体 及表达系统可以从Novagen公司、宝酒造、第一化学药品、Qiagen公 司、Stratagene公司、Promega公司、Roche Diagnositics公司、Invitrogen 公司、Genetics Institute公司、Amersham Bioscience公司等购买。
作为宿主细胞，可以使用细菌等原核细胞(例如大肠杆菌、枯草 杆菌)、酵母(例如酿酒酵母)、昆虫细胞(例如Sf细胞)、哺乳动 物细胞(例如COS、CHO、BHK)等。
载体中除含有编码该多肽的DNA以外，还可以含有调节元件，例 如启动子、增强子、多聚腺苷酸化信号、核糖体结合部位、复制起点、 终止子、选择标记等。为了容易进行多肽的纯化，可以将多肽制成在 多肽的C末端或N末端结合了标记肽的融合多肽。作为代表性的标记 肽，可以举出6～10个残基的组氨酸重复序列、FLAG、myc肽、GFP 多肽等，但标记肽并不限定于此。DNA重组技术记载于Sambrook，J. &Russel，D.(参见上述记载)。
在不结合标记肽的状态下制备本发明的多肽时，作为其纯化方 法，例如可以举出利用超滤、盐析、凝胶过滤、离子交换色谱等的方 法。除此之外，还可以使用组合亲和色谱、HPLC、疏水性色谱、等 电点色谱等的方法。另一方面，在该蛋白质上结合组氨酸重复序列、 FLAG、myc、GFP等标记肽时，可以举出适合通常使用的各种标记肽 的亲和色谱法。可以构建能易于分离、纯化的表达载体。特别是构建 能以多肽和标记肽的融合多肽的形式进行表达的表达载体，利用基因 工程技术制备该多肽时，也可容易地进行分离、纯化。
本发明中上述多肽的变异体如上述定义所述，是在序列号101～ 197表示的氨基酸序列或其部分序列中，缺失、置换、添加或插入1个 以上、优选1个或数个氨基酸的变异体、或者与该氨基酸序列或其部 分序列具有约80％以上、约85％以上、优选约90％以上、较优选约95 ％以上、约97％以上、约98％以上、约99％以上的同源性百分比的变 异体。上述变异体例如包括不同于人的哺乳动物种的同源物、以人的 多态性变异或剪接变异为基础的变异体等天然变异体。
本发明中上述多肽或变异体的片段，由该多肽的氨基酸序列的至 少5个、至少7个、至少10个、至少15个、优选至少20个、至少25个、 较优选至少30个、至少40个、至少50个连续氨基酸残基构成，并保持 1个或几个表位。上述片段可以免疫特异性地与本发明的抗体或其片 段结合。推测上述多肽可能在存在于生物体内的蛋白酶或肽酶等酶的 作用下被切断而形成片段，以片段形式存在。
识别如上所述得到的多肽的抗体可以通过抗体的抗原结合部位 特异性结合该多肽。具体而言，可以将具有序列号101～197的氨基酸 序列的多肽或其片段、其变异体多肽或融合多肽等，分别用作用于产 生免疫反应性抗体的免疫原。
更具体而言，多肽、片段、变异体、融合多肽等含有促使抗体形 成的抗原决定簇或表位，上述抗原决定簇或表位可以是直链，也可以 是较高级结构(断开)。需要说明的是，该抗原决定簇或表位可以通 过本领域已知的所有表位分析法、例如噬菌体展示技术(Phage display)、反向免疫遗传学技术(reverse immunogenetics)等进行确定。
利用本发明的多肽能诱导所有种类的抗体。如果分离该多肽的全 部或一部分或表位，那么使用常规技术即可制备多克隆抗体及单克隆 抗体中的任一种。方法例如包括Kennet等(主编)，Monoclonal Antibodies，Hybridomas：A New Dimension in Biological Analyses， Ple num Press，NewYork，1980中列举的方法。
多克隆抗体可以通过用本发明的多肽免疫禽类(例如鸡等)、哺 乳动物(例如家兔、山羊、马、绵羊、小鼠等)等动物进行制备。可 以适当组合硫酸铵分级分离、离子交换色谱、亲和色谱等方法，从被 免疫的动物的血液中纯化目标抗体。
单克隆抗体可以通过包括利用常规技术在小鼠中生产杂交瘤细 胞株的方法得到，所述杂交瘤细胞株产生对各多肽特异的单克隆抗 体。用于生产上述杂交瘤细胞株的1种方法如下所述：用本发明的酶 多肽免疫动物，从被免疫的动物中采集脾细胞，使该脾细胞与骨髓瘤 细胞株融合，由此制备杂交瘤细胞，然后鉴定生产与该酶结合的单克 隆抗体的杂交瘤细胞。单克隆抗体可以通过常规技术回收。
作为本发明的抗体，只要是能与本发明的靶多肽或其片段特异性 结合的抗体即可，没有特别限定，可以使用单克隆抗体，也可以使用 多克隆抗体，优选使用单克隆抗体。其他抗体包括重组抗体、合成酶、 多特异性抗体(例如，双特异性抗体)、单链抗体、抗体片段等。上 述抗体的例子为Fab、F(ab’)2、scFv、Fv、dsFv等。本发明抗体的 球蛋白类型只要具有上述特征即可，没有特别限定，可以是IgG、IgM、 IgA、IgE、IgD中的任一种。
<单克隆抗体的制备>
(1)免疫及抗体产生细胞的采集
对哺乳动物例如大鼠、小鼠(例如近交系小鼠Balb/c)、家兔等 给予由靶多肽构成的免疫原。免疫原的1次给药量可以根据免疫动物 种类、给药途径等适当确定，每1只动物给药约50～200μg。主要通过 在皮下、腹腔内注入免疫原进行免疫。另外，免疫的间隔没有特别限 定，初次免疫后，间隔数日至数周，优选间隔1～4周，进行2～10次、 优选3～4次加强免疫。初次免疫后，利用ELISA(酶联免疫吸附测定 (Enzyme-Linked Immuno Sorbent Assay))法等反复测定免疫动物 血清中的抗体值，抗体值达到平台时，向静脉内或腹腔内注射免疫原， 进行最终免疫。从最终免疫日起2～5日后，优选3日后，采集抗体产生 细胞。作为抗体产生细胞，可以举出脾细胞、淋巴结细胞、外周血细 胞等，优选脾细胞或局部淋巴结细胞。
(2)细胞融合
制备产生对各靶多肽特异的单克隆抗体的杂交瘤细胞株。该杂交 瘤可以通过常规技术进行生产并鉴定。用于生产该杂交瘤细胞株的方 法之一是用本发明的蛋白质免疫动物，从被免疫的动物中采集脾细 胞，使该脾细胞与骨髓瘤细胞株融合，由此生成杂交瘤细胞，鉴定产 生与该酶结合的单克隆抗体的杂交瘤细胞株。作为能与抗体产生细胞 融合的骨髓瘤细胞株，可以使用通常能购买到的小鼠等动物的细胞 株。作为使用的细胞株，优选具有下述性质的细胞株，即具有药剂选 择性，并具有在未融合状态下在HAT选择培养基(含有次黄嘌呤、氨 基蝶呤、胸腺嘧啶)中不能存活，只有在与抗体产生细胞融合的状态 下才能存活的性质。细胞株优选来自与免疫动物同种系的动物的细 胞。作为骨髓瘤细胞株的具体例，可以举出来自BALB/c小鼠的次黄 嘌呤·鸟嘌呤·磷酸核糖基·转移酶(HGPRT)缺陷细胞株P3X63- Ag.8株(ATCC TIB9)等。
接下来使上述骨髓瘤细胞株与抗体产生细胞进行细胞融合。细胞 融合如下进行：在不含有血清的DMEM、RPMI-1640培养基等动物 细胞培养用培养基中，以约1∶1～20∶1的比例混合抗体产生细胞和 骨髓瘤细胞株，在细胞融合促进剂的存在下进行融合反应。作为细胞 融合促进剂，可以使用浓度约为10～80％、平均分子量为1500～4000 道尔顿的聚乙二醇等。另外，视情况的不同，为了提高融合效率，可 以并用二甲基亚砜等辅助剂。还可以使用利用电刺激(例如电穿孔) 的市售的细胞融合装置使抗体产生细胞和骨髓瘤细胞株融合。
(3)杂交瘤的筛选及克隆
从细胞融合处理后的细胞中筛选目标杂交瘤。作为筛选方法，使 用例如含有胎牛血清的RPMI-1640培养基等适当稀释细胞悬浮液 后，以约200万个细胞/孔接种到微孔板上，向各孔中加入选择培养基， 并在以后适当更换选择培养基，进行培养。培养温度为20～40℃、优 选为约37℃。骨髓瘤细胞是HGPRT缺陷株或胸苷激酶缺陷株时，可以 通过使用含有次黄嘌呤·氨基蝶呤·胸腺嘧啶核苷的选择培养基(HAT 培养基)，仅选择性培养、增殖具有抗体产生能力的细胞与骨髓瘤细 胞株的杂交瘤。结果在用选择培养基开始培养后，生长约14天左右的 细胞可以作为杂交瘤被得到。
接下来，对进行了增殖的杂交瘤的培养上清液中是否存在目标抗 体进行筛选。杂交瘤的筛选可以按照常规方法进行，没有特别限定。 例如，采集作为杂交瘤培养的包含在孔中的培养上清液的一部分，通 过酶免疫测定法(EIA：Enzyme Immuno Assay、及ELISA)、放射免 疫测定法(RIA：Radio Immuno Assay)等进行筛选。融合细胞的克 隆通过极限稀释法等进行，从而最终确立产生单克隆抗体的细胞即杂 交瘤。本发明的杂交瘤如后所述，在RPMI-1640、DMEM等基本培 养基中的培养稳定，并能产生、分泌与靶多肽特异性反应的单克隆抗 体。
(4)抗体的回收
单克隆抗体可以利用常规技术进行回收。即，作为从确立的杂交 瘤中采集单克隆抗体的方法，可以采用通常的细胞培养法或腹水形成 法等。采用细胞培养法时，在通常的培养条件(例如，37℃、5％CO2 浓度)下，在含有10％胎牛血清的RPMI-1640培养基、MEM培养基 或无血清培养基等动物细胞培养基中培养杂交瘤2～10日，从该培养上 清液中获得抗体。采用腹水形成法的情况下，向与提供骨髓瘤细胞的 哺乳动物同种系的动物的腹腔内给予约1000万个杂交瘤，使杂交瘤大 量增殖。并在1～2周后采集腹水或血清。
对于上述抗体的采集方法，在需要纯化抗体的情况下，可以通过 适当选择硫酸铵盐析法、离子交换色谱法、亲和色谱法、凝胶过滤色 谱法等公知的方法，或组合使用上述方法，得到纯化的单克隆抗体。
<多克隆抗体的制备>
制备多克隆抗体时，与上述相同，免疫家兔等动物，从最终免疫 日起6～60天后，利用酶免疫测定法(EIA及ELISA)、放射免疫测定 法(RIA)等测定抗体值，在显示最大抗体值的当天采血，得到抗血 清。然后，利用ELISA法等测定抗血清中的多克隆抗体的反应性。
<化学修饰衍生物>
本发明的抗体或其片段可以是经化学修饰的衍生物。例如，可以 举出利用酶、荧光团、放射性同位素等标记得到的标记化衍生物，或 乙酰化、酰化、烷基化、磷酸化、硫酸化、糖基化衍生物等化学修饰 衍生物。
作为标记物质，在酶免疫测定法中，可以使用过氧化物酶(POD)、 碱性磷酸酶、β-半乳糖苷酶、脲酶、过氧化氢酶、葡萄糖氧化酶、 乳酸脱氢酶、淀粉酶等酶或生物素-抗生物素蛋白复合体，荧光免疫 测定法中，可以使用异硫氰酸荧光素、四甲基罗丹明异硫氰酸盐、取 代异硫氰酸罗丹明、二氯三嗪异硫氰酸盐、Alexa或AlexaFluoro等荧 光性物质或荧光团，放射免疫测定法中，可以使用氚、碘(131I，125I， 123I，121I)、磷(32P)、硫(35S)、金属类(例如68Ga，67Ga，68Ge， 54Mn，99Mo，99Tc，133Xe等)等放射性同位素。发光免疫测定法可以 使用NADH-、FMNH2-、荧光素酶类、鲁米诺-过氧化氢-POD 类、吖啶酯类或二氧杂环丁烷化合物类等发光性分子、发光物质、生 物发光物质。
另外，根据需要，还可以利用抗生物素蛋白-生物素系统或链霉 抗生物素蛋白-生物素系统，此种情况下，可以在本发明的抗体或其 片段上结合例如生物素。对于标记物质和抗体的结合法，在酶免疫测 定法中，可以使用戊二醛法、马来酰亚胺法、吡啶基二硫化物或高碘 酸法等公知的方法，放射免疫测定法中，可以使用氯胺T法、Bolton -Hunter法等公知的方法。
4.肾癌诊断用及/或肾癌预后预测或转移预测用试剂盒
4.1核酸试剂盒
本发明还提供用于体外检测、确定或预测肾癌的存在或肾癌的转 移、或预后预测的试剂盒，其中含有上述2中的I组中记载的多核苷 酸、其变异体及/或其片段中的1种或几种。
本发明的试剂盒中可以含有下述I组中的核酸探针。上述各探针可 以单独或组合收纳在适当的容器中。
即、本发明的试剂盒可以含有下述多核苷酸中的至少一种，所述 多核苷酸为含有序列号1～10、12～20、22～47表示的碱基序列的多 核苷酸、含有其互补序列的多核苷酸、与上述多核苷酸在严格条件下 杂交的多核苷酸、或上述多核苷酸的片段。
本发明的试剂盒可以进一步含有下述多核苷酸中的至少一种，所 述多核苷酸为含有序列号11、21、48～50表示的碱基序列的多核苷酸、 含有其互补序列的多核苷酸、与上述多核苷酸在严格条件下杂交的多 核苷酸、或上述多核苷酸的片段。
本发明的试剂盒中可以含有的多核苷酸片段例如是选自下述(1) ～(5)中的1种以上DNA：
(1)序列号1～10、11、12～20、21、22～47、48～50表示的碱 基序列或其互补序列中，含有15个以上连续碱基的DNA。
(2)序列号1～10、11、12～20、21、22～47、48～50表示的碱 基序列或其互补序列中，含有60个以上连续碱基的DNA。
(3)序列号1～10、11、12～20、21、22～47、48～50表示的碱 基序列或其互补序列中，分别含有序列号51～60、61、62～70、71、 72～97、98～100表示的碱基序列或其互补序列、且含有60个以上连 续碱基的DNA。
(4)由序列号51～60、61、62～70、71、72～97、98～100表示 的碱基序列构成的DNA。
(5)含有与序列号51～60、61、62～70、71、72～97、98～100 表示的碱基序列互补的碱基序列的DNA。
优选实施方案中，上述多核苷酸是由序列号1～10、12～20、22～ 47中任一个表示的碱基序列构成的多核苷酸、由其互补序列构成的多 核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、或其含有15 个以上连续碱基的片段。
其它优选实施方案中，本发明的试剂盒除含有上述多核苷酸之 外，还可以含有由序列号11、21、48～50表示的碱基序列构成的多核 苷酸、由其互补序列构成的多核苷酸、与上述多核苷酸在严格条件下 杂交的多核苷酸、或其含有15个以上连续碱基的片段。
优选实施方案中，上述片段可以是含有15个以上、优选60个以上 的连续碱基的多核苷酸。
其它优选实施方案中，上述片段是在序列号1～10、11、12～20、 21、22～47、48～50中任一个表示的碱基序列中，分别含有序列号51～ 60、61、62～70、71、72～97、98～100中任一个表示的碱基序列、 且含有60个以上连续碱基的多核苷酸、或含有与该多核苷酸的序列互 补的碱基序列的多核苷酸。
其它优选实施方案中，上述片段是含有序列号51～60、61、62～ 70、71、72～97、98～100中任一个表示的碱基序列的多核苷酸。
其它优选实施方案中，上述片段是含有与序列号51～60、61、62～ 70、71、72～97、98～100中任一个表示的碱基序列互补的碱基序列 的多核苷酸。
其它优选实施方案中，上述片段是由序列号51～60、61、62～70、 71、72～97、98～100中任一个表示的碱基序列构成的多核苷酸。
上述组合的具体例为，含有序列号1及2的碱基序列或其互补序列 的多核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、及/或 其片段，含有序列号1～3的碱基序列或其互补序列的多核苷酸、与上 述多核苷酸在严格条件下杂交的多核苷酸、及/或其片段，含有序列 号1～4的碱基序列或其互补序列的多核苷酸、与上述多核苷酸在严格 条件下杂交的多核苷酸、及/或其片段，含有序列号1～5的碱基序列 或其互补序列的多核苷酸、与上述多核苷酸在严格条件下杂交的多核 苷酸、及/或其片段，含有序列号1～6的碱基序列或其互补序列的多 核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、及/或其片 段，含有序列号1～7的碱基序列或其互补序列的多核苷酸、与上述多 核苷酸在严格条件下杂交的多核苷酸、及/或其片段，含有序列号1～ 8的碱基序列或其互补序列的多核苷酸、与上述多核苷酸在严格条件 下杂交的多核苷酸、及/或其片段，含有序列号1～9的碱基序列或其 互补序列的多核苷酸、与上述多核苷酸在严格条件下杂交的多核苷 酸、及/或其片段，含有序列号1～10的碱基序列或其互补序列的多 核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、或其片段， 含有序列号1～11的碱基序列或其互补序列的多核苷酸、与上述多核 苷酸在严格条件下杂交的多核苷酸、及/或其片段，含有序列号1～ 12的碱基序列或其互补序列的多核苷酸、与上述多核苷酸在严格条件 下杂交的多核苷酸、及/或其片段，含有序列号1～13的碱基序列或 其互补序列的多核苷酸、与上述多核苷酸在严格条件下杂交的多核苷 酸、及/或其片段，含有序列号1～14的碱基序列或其互补序列的多 核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、及/或其片 段，含有序列号1～15的碱基序列或其互补序列的多核苷酸及/或其 片段，含有序列号1～16的碱基序列或其互补序列的多核苷酸、与上 述多核苷酸在严格条件下杂交的多核苷酸、及/或其片段，含有序列 号1～17的碱基序列或其互补序列的多核苷酸及/或其片段，含有序 列号1～18的碱基序列或其互补序列的多核苷酸、与上述多核苷酸在 严格条件下杂交的多核苷酸、及/或其片段，含有序列号1～19的碱 基序列或其互补序列的多核苷酸、与上述多核苷酸在严格条件下杂交 的多核苷酸、及/或其片段，含有序列号1～20的碱基序列或其互补 序列的多核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、及 /或其片段，含有序列号1～21的碱基序列或其互补序列的多核苷酸、 与上述多核苷酸在严格条件下杂交的多核苷酸、及/或其片段，含有 序列号1～22的碱基序列或其互补序列的多核苷酸、与上述多核苷酸 在严格条件下杂交的多核苷酸、及/或其片段，含有序列号1～23的 碱基序列或其互补序列的多核苷酸、与上述多核苷酸在严格条件下杂 交的多核苷酸、及/或其片段，含有序列号1～24的碱基序列或其互 补序列的多核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、 及/或其片段，含有序列号1～25的碱基序列或其互补序列的多核苷 酸、与上述多核苷酸在严格条件下杂交的多核苷酸、及/或其片段， 含有序列号1～26的碱基序列或其互补序列的多核苷酸、与上述多核 苷酸在严格条件下杂交的多核苷酸、及/或其片段，含有序列号1～ 27的碱基序列或其互补序列的多核苷酸、与上述多核苷酸在严格条件 下杂交的多核苷酸、及/或其片段，含有序列号1～28的碱基序列或 其互补序列的多核苷酸、与上述多核苷酸在严格条件下杂交的多核苷 酸、及/或其片段，含有序列号1～29的碱基序列或其互补序列的多 核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、及/或其片 段，含有序列号1～30的碱基序列或其互补序列的多核苷酸、与上述 多核苷酸在严格条件下杂交的多核苷酸、及/或其片段，含有序列号 1～31的碱基序列或其互补序列的多核苷酸、与上述多核苷酸在严格 条件下杂交的多核苷酸、及/或其片段，含有序列号1～32的碱基序 列或其互补序列的多核苷酸、与上述多核苷酸在严格条件下杂交的多 核苷酸、及/或其片段，含有序列号1～33的碱基序列或其互补序列 的多核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、及/或 其片段，含有序列号1～34的碱基序列或其互补序列的多核苷酸、与 上述多核苷酸在严格条件下杂交的多核苷酸、及/或其片段，含有序 列号1～35的碱基序列或其互补序列的多核苷酸、与上述多核苷酸在 严格条件下杂交的多核苷酸、及/或其片段，含有序列号1～36的碱 基序列或其互补序列的多核苷酸、与上述多核苷酸在严格条件下杂交 的多核苷酸、及/或其片段，含有序列号1～37的碱基序列或其互补 序列的多核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、及 /或其片段，含有序列号1～38的碱基序列或其互补序列的多核苷酸、 与上述多核苷酸在严格条件下杂交的多核苷酸、及/或其片段，含有 序列号1～39的碱基序列或其互补序列的多核苷酸、与上述多核苷酸 在严格条件下杂交的多核苷酸、及/或其片段，含有序列号1～40的 碱基序列或其互补序列的多核苷酸、与上述多核苷酸在严格条件下杂 交的多核苷酸、及/或其片段，含有序列号1～41的碱基序列或其互 补序列的多核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、 及/或其片段，含有序列号1～42的碱基序列或其互补序列的多核苷 酸、与上述多核苷酸在严格条件下杂交的多核苷酸、及/或其片段， 含有序列号1～43的碱基序列或其互补序列的多核苷酸、与上述多核 苷酸在严格条件下杂交的多核苷酸、及/或其片段，含有序列号1～ 44的碱基序列或其互补序列的多核苷酸、与上述多核苷酸在严格条件 下杂交的多核苷酸、及/或其片段，含有序列号1～45的碱基序列或 其互补序列的多核苷酸、与上述多核苷酸在严格条件下杂交的多核苷 酸、及/或其片段，含有序列号1～46的碱基序列或其互补序列的多 核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、及/或其片 段，含有序列号1～47的碱基序列或其互补序列的多核苷酸、与上述 多核苷酸在严格条件下杂交的多核苷酸、及/或其片段，含有序列号 1～48的碱基序列或其互补序列的多核苷酸、与上述多核苷酸在严格 条件下杂交的多核苷酸、及/或其片段，含有序列号1～49的碱基序 列或其互补序列的多核苷酸、与上述多核苷酸在严格条件下杂交的多 核苷酸、及/或其片段，含有序列号1～50的碱基序列或其互补序列 的多核苷酸、与上述多核苷酸在严格条件下杂交的多核苷酸、及/或 其片段。
根据其它较优选实施方案，本发明的试剂盒可以含有下述多核苷 酸中的2种以上～全部，所述多核苷酸为含有序列号51～97、98～100 表示的碱基序列或其互补序列的多核苷酸。
其它组合的具体例为含有序列号1～19、48的碱基序列或其互补 序列或由上述序列构成的多核苷酸及/或其片段。
其它组合的具体例还有含有序列号20～47、49及50的碱基序列或 其互补序列或由上述序列构成的多核苷酸及/或其片段。
本发明中，上述多核苷酸片段的大小是各多核苷酸碱基序列中下 述范围的连续碱基数，例如15～序列的全部碱基数、15～5000个碱基、 15～4500个碱基、15～4000个碱基、15～3500个碱基、15～3000个碱 基、15～2500个碱基、15～2000个碱基、15～1500个碱基、15～1000 个碱基、15～900个碱基、15～800个碱基、15～700个碱基、15～600 个碱基、15～500个碱基、15～400个碱基、15～300个碱基、15～250 个碱基、15～200个碱基、15～150个碱基、15～140个碱基、15～130 个碱基、15～120个碱基、15～110个碱基、15～100个碱基、15～90 个碱基、15～80个碱基、15～70个碱基、15～60个碱基、15～50个碱 基、15～40个碱基、15～30个碱基或15～25个碱基，25～序列的全部 碱基数、25～1000个碱基、25～900个碱基、25～800个碱基、25～700 个碱基、25～600个碱基、25～500个碱基、25～400个碱基、25～300 个碱基、25～250个碱基、25～200个碱基、25～150个碱基、25～140 个碱基、25～130个碱基、25～120个碱基、25～110个碱基、25～100 个碱基、25～90个碱基、25～80个碱基、25～70个碱基、25～60个碱 基、25～50个碱基或25～40个碱基；50～序列的全部碱基数、50～1000 个碱基、50～900个碱基、50～800个碱基、50～700个碱基、50～600 个碱基、50～500个碱基、50～400个碱基、50～300个碱基、50～250 个碱基、50～200个碱基、50～150个碱基、50～140个碱基、50～130 个碱基、50～120个碱基、50～110个碱基、50～100个碱基、50～90 个碱基、50～80个碱基、50～70个碱基或50～60个碱基；60～序列的 全部碱基数、60～1000个碱基、60～900个碱基、60～800个碱基、60～ 700个碱基、60～600个碱基、60～500个碱基、60～400个碱基、60～ 300个碱基、60～250个碱基、60～200个碱基、60～150个碱基、60～ 140个碱基、60～130个碱基、60～120个碱基、60～110个碱基、60～ 100个碱基、60～90个碱基、60～80个碱基或60～70个碱基等。
构成本发明的试剂盒的上述组合只是列举，其他各种可能的组合 都包括在本发明中。
本发明的试剂盒除了上述说明的本发明的多核苷酸、其变异体或 其片段之外，还可以含有已知或将来发现的能够检测肾癌或预测肾癌 转移或预测预后的多核苷酸。
4.2抗体试剂盒
另外，本发明还提供一种用于体外检测、确定或预测肾癌的存在 或肾癌的转移或预后预测的试剂盒，其中包含上述2中的II组中记载的 抗体、其片段或其化学修饰衍生物、上述3.2中记载的抗体、其片段或 其化学修饰衍生物中的1种或几种。
本发明的试剂盒中可以含有下述II组(f)、(g)及(h)中的抗 体、其片段或其化学修饰衍生物作为探针。上述各探针可以单独或组 合收纳在适当的容器中。
探针的组合例如下所示。
第1例探针为了检测作为肾癌预后预测用或肾癌转移标记物的 PABPN1、PINK1、TFF2、EIF3S9、MAX、MLL4、CACNB2、ZMYND11、 BAT2、NRBP、MCM3AP、COL4A1、MKNK1、BBC3、FLJ10359、 DPT、C10orf76、DIA1、PBK、PRKD2、KRT19、FLJ23436、NPHS2、 C3orf14、AGTR2、HTR1F、KIF3B、DCN、STK22C、DKFZp566C0424、 CNR1、HOMER3、GPR2、FLJ12442、XLKD1，CASKIN2、COL5A2、 BRD3、ATP6V0A4、PRODH2、EPHB2、LYAR、COX6B、PRH1、 LAPTM5、RPS6KA4、GCC2、FGF2、MMP14及ERBB2基因编码的多 肽、其同源物、或其变异体或衍生物而含有1种或几种、优选2种以上 针对上述多肽、其变异体或其片段的抗体。
具体而言，试剂盒中含有的探针是与具有序列号101～110、112～ 120、122～147表示的氨基酸序列的多肽、其变异体、或其片段中的 至少1个特异性结合的1种或几种抗体、该抗体的片段、或其化学修饰 衍生物。
该试剂盒中可以进一步含有针对具有序列号11I、121、148～150 表示的氨基酸序列的多肽的抗体、该抗体的片段或其化学修饰衍生 物。通过并用，能提高转移的预测或术后预后的预测准确度。
第2例探针为针对下述多肽的1种或多种抗体、其片段、或其化学 修饰衍生物，所述多肽作为肾癌标记物含有上述II组(g)、(h)分 别记载的序列号151、153、155～160、序列号161～190表示的氨基酸 序列
该试剂盒中还可以包含针对含有序列号152、154、191、192～197 表示的氨基酸序列的多肽的抗体、其片段或其化学修饰衍生物。通过 并用，能提肾癌检测的准确度。
本发明的试剂盒中含有的抗体可以单独存在，也可以以混合物的 状态存在，或与固相载体结合存在，也可以以游离状态存在。另外， 本发明的试剂盒可以含有标记二抗、载体、清洗缓冲液、试样稀释液、 酶底物、反应停止液、纯化的作为标准物质的标记物(靶)多肽、使 用说明书等。
5.DNA芯片
本发明还提供用于检测肾癌或预测肾癌预后或预测转移的DNA 芯片，所述DNA芯片单独或组合、优选组合使用与上述3及/或4中记 载的本发明的组合物及/或试剂盒中含有的物质相同的多核苷酸、变异 体或片段。
作为DNA芯片的基板，只要是能够将DNA固定化的基板即可，没 有特别限定，可以举出载玻片、硅制芯片、聚合物制芯片及尼龙膜等。 另外，可以对上述基板进行聚L赖氨酸涂布或导入氨基、羧基等官能 团等表面处理。
另外，固定化法只要是通常使用的方法即可，没有特别限定，可 以举出以下方法：使用被称为点样器(spotter)或阵列点样仪(arrayer) 的高密度分液器点样DNA的方法、或使用通过压电元件等从喷嘴喷射 微量的液滴的装置(喷墨)将DNA喷射到基板上的方法、或在基板上 依次进行核苷酸合成的方法。使用高密度分液器时，例如如下进行固 定化：在具有多个孔的平板的各孔中装入不同的基因溶液，用针取出 该溶液，然后依次点到基板上。使用喷墨法时，如下进行固定化：从 喷嘴喷射基因，将基因高速地排列在基板上。在基板上合成DNA时， 如下进行固定化：用能在光的作用下离去的官能团保护与基板结合的 碱基，通过使用掩模只对特定部位的碱基曝光，使官能团离去。然后， 反复进行向反应液中加入碱基、使其与基板上的碱基偶联的步骤。
能够被固定化的多核苷酸是上述说明的本发明的全部多核苷酸。
例如，上述多核苷酸可以含有以下1种或几种多核苷酸或其片段。
(1)由序列号1～50表示的碱基序列构成的多核苷酸、其变异体、 或其含有15个以上连续碱基的片段。
(2)含有序列号1～50表示的碱基序列的多核苷酸。
(3)由序列号1～10、12～20、22～47表示的碱基序列构成的多 核苷酸、其变异体、或其含有15个以上连续碱基的片段。
(4)含有序列号1～10、12～20、22～47表示的碱基序列的多核 苷酸、其变异体、或其含有15个以上连续碱基的片段。
(5)由与序列号1～10、12～20、22～47表示的碱基序列互补的 碱基序列构成的多核苷酸、其变异体、或其含有15个以上连续碱基的 片段。
(6)含有与序列号1～10、12～20、22～47表示的碱基序列互补 的碱基序列的多核苷酸。
(7)与下述DNA在严格条件下杂交的多核苷酸、或其含有15个 以上连续碱基的片段，所述DNA由与序列号1～10、12～20、22～47 表示的各个碱基序列互补的碱基序列构成。
(8)与下述DNA在严格条件下杂交的多核苷酸、或其含有15个 以上连续碱基的片段，所述DNA由序列号1～10、12～20、22～47表 示的各个碱基序列构成。
(9)由序列号11、21、48～50表示的碱基序列构成的多核苷酸、 其变异体、或其含有15个以上连续碱基的片段。
(10)含有序列号11、21、48～50表示的碱基序列的多核苷酸、 其变异体、或其含有15个以上连续碱基的片段。
(11)由与序列号11、21、48～50表示的碱基序列互补的碱基序 列构成的多核苷酸、其变异体、或其含有15个以上连续碱基的片段。
(12)含有与序列号11、21、48～50表示的碱基序列互补的碱基 序列的多核苷酸。
(13)与下述DNA在严格条件下杂交的多核苷酸、或其含有15个 以上连续碱基的片段，所述DNA由与序列号11、21、48～50表示的各 个碱基序列互补的碱基序列构成。
(14)与下述DNA在严格条件下杂交的多核苷酸、或其含有15个 以上连续碱基的片段，所述DNA由序列号11、21、48～50表示的各个 碱基序列构成。
(15)在序列号1～10、12～20、22～47表示的碱基序列或其互 补序列的各序列中、含有15个以上连续碱基的多核苷酸。
(16)序列号1～10、12～20、22～47表示的碱基序列或其互补 序列的各序列中、含有60个以上连续碱基的多核苷酸。
(17)序列号11、21、48～50表示的碱基序列或其互补序列的各 序列中、含有15个以上连续碱基的多核苷酸。
(18)序列号11、21、48～50表示的碱基序列或其互补序列的各 序列中、含有60个以上连续碱基的多核苷酸。
(19)序列号1～10、12～20、22～47表示的碱基序列中，分别 含有序列号51～60、62～70、72～97表示的碱基序列、且含有60个以 上连续碱基的多核苷酸。
(20)与序列号1～10、12～20、22～47表示的碱基序列互补的 序列中，分别含有与序列号51～60、62～70、72～97表示的碱基序列 互补的序列、且含有60个以上连续碱基的多核苷酸。
(21)序列号11、21、48～50表示的碱基序列中，分别含有序列 号61、71、98～100表示的碱基序列、且含有60个以上连续碱基的多 核苷酸。
(22)与序列号11、21、48～50表示的碱基序列互补的序列中， 分别含有与序列号61、71、98～100表示的碱基序列互补的序列、且 含有60个以上连续碱基的多核苷酸。
根据优选实施方案，本发明的试剂盒可以包含2种以上至全部的 含有序列号51～60、61、62～70、71、72～97、98～100表示的碱基 序列或其互补序列的多核苷酸。
本发明中，固定化的多核苷酸可以为基因组DNA、cDNA、RNA、 合成DNA、合成RNA中的任一种，可以为单链也可以为双链。
作为能够检测、测定靶基因、RNA或cDNA的表达水平的DNA芯 片的例子，可以举出Affymetrix公司的Gene Chip Human Genome U133 Plus 2.0Array、Agilent公司的Whole human genome oligo microarray、 Takara Bio公司的IntelliGene(注册商标)HS Human Expression CHIP、 具有凹凸结构的聚甲基丙烯酸甲酯制DNA芯片基板(日本特开2004 -264289)等。
DNA微阵列的制作例如可以使用在固相表面固定预先制备的探 针的方法。在固相表面固定预先制备的多核苷酸探针的方法如下：合 成导入了官能团的多核苷酸，在经过表面处理的固相载体表面上点样 寡核苷酸或多核苷酸，使其共价键合(例如、J.B.Lamture等、 Nucleic.Acids.Research、1994年，第22卷，p.2121-2125、Z.Guo等、 Nucleic.Acids.Research、1994年，第22卷，p.5456-5465)。多核苷酸 通常通过间隔臂(spacer)或交联剂(crosslinker)与经过表面处理的 固相载体共价键合。还已知使聚丙烯酰胺凝胶的微小片排列在玻璃表 面上，使合成多核苷酸与其共价键合的方法(G.Yershov等、Proceedings ofthe National Academic Sciences U.S.A.、1996年，第94卷，p.4913)。 还已知下述方法：在二氧化硅微阵列上制作微小电极的阵列，在电极 上设置含有链霉抗生物素蛋白的琼脂糖的渗透层，形成反应部位，通 过使该部位带正电，固定生物素化多核苷酸，通过控制部位的电荷， 能高速且严格地进行杂交(R.G.Sosnowski等、Proceedings of the National Academic Sciences U.S.A.、1997年，第94卷，p.1119-1123)。
6.肾癌存在的检测、确定方法及/或肾癌的预后或转移预测方法
本发明提供一种方法，所述方法使用本发明的组合物、试剂盒、 DNA芯片、或它们的组合，通过将来自受试者的肾癌细胞生物试样中 靶核酸的表达水平，与来自预后不良肾癌患者群体的肾癌细胞中靶核 酸的表达水平及/或来自预后良好患者群体的肾癌细胞中靶核酸的 表达水平比较，体外预测受试者的预后及/或肾癌转移的有无，其中， 该靶核酸是可通过该组合物、试剂盒或DNA芯片中所含的多核苷酸、 其变异体或其片段检测的核酸，且在确认来自受试者的该靶核酸的表 达水平，与预后良好肾癌患者群体的表达水平及/或预后不良患者群 体的表达水平相比发生变化时，分别确定受试者预后不良、或受试者 预后良好、及/或者确定肾癌转移、或肾癌未转移。
本发明还提供本发明的组合物、试剂盒或DNA芯片在体外检测来 自受试者的生物试样中预测发生了转移的肾癌细胞中的用途。
本发明的上述方法使用下述组合物、试剂盒或DNA芯片，所述组 合物、试剂盒或DNA芯片单独或者以所有可能的组合包含上述说明的 本发明的多核苷酸、其变异体或其片段。
在本发明的肾癌转移的预测、检测或(基因)诊断、及/或肾癌 患者预后的预测中，本发明的组合物、试剂盒或DNA芯片中所含的多 核苷酸、其变异体或其片段，可以作为引物或作为检测探针(探测物) 使用。作为引物使用时，可以举出碱基长度通常为15～50个碱基、优 选15～30个碱基、较优选18～25个碱基的探针。另外，作为检测探针 使用时，例如可以举出碱基长度为15碱基～全部序列的碱基数、优选 25～1000个碱基、较优选25～100个碱基的探针，但并不限定于此范 围。
本发明的组合物或试剂盒中含有的多核苷酸、其变异体或其片 段，在RNA印迹法(Northern Blot)、RT-PCR法、原位杂交法、DNA 杂交法等特异性地检测特定基因的公知方法中，可以根据标准方法用 作引物或探针。作为测定对象试样，根据所用的检测方法的种类，可 以通过活组织检测等采集受试者的肾组织或被怀疑存在肾癌细胞的 生物组织的一部分或全部，或者从手术取出的生物组织中回收。还可 以使用按照常规方法由其制备的总RNA，还可以使用基于该RNA制备 的包括cDNA、聚A(+)RNA在内的各种多核苷酸。
或者，可以使用DNA芯片(包括DNA宏阵列)检测或定量生物组 织中的本发明的基因、RNA、cDNA等核酸的表达量。此种情况下， 本发明的组合物或试剂盒可以用作DNA阵列的探针(例如，在 Affymetrix公司的Human Genome U133 Plus 2.0 Array中，使用长度为 25个碱基的多核苷酸探针)。使上述DNA阵列与以从生物组织采集的 RNA为基础制备的标记DNA或RNA杂交，以该标记DNA或RNA的标 记为指标，检测通过该杂交形成的上述探针和标记DNA或RNA的复合 体，由此能评价生物组织中的肾癌转移及/或肾癌患者预后预测相关基 因是否表达或表达水平(表达量)。本发明方法中优选使用DNA芯片， 该DNA芯片能对一个生物试样同时评价多个基因是否表达或表达水 平。
本发明的组合物、试剂盒或DNA芯片对用于肾癌患者预后预测及 /或转移的预测、确定或检测(是否患病或患病程度的诊断)是有用 的。具体而言，使用该组合物、试剂盒或DNA芯片的肾癌患者预后预 测及/或转移预测可以如下进行：在受试者的存在肾癌细胞的生物组 织中测定用该诊断用组合物能够检测到的基因的表达水平。此时，基 因表达水平不仅包括是否表达的情况，还包括下述情况：在来自预后 良好的患者的存在肾癌细胞的生物组织和来自预后不良的患者的存 在肾癌细胞的生物组织中均表达时，比较两者间的表达量时的差有统 计学意义(p值＜0.05)。例如，由于PABPN1基因在来自预后不良的 患者的肾癌中显示表达诱导/减少，所以在预后不良的受试者的肾癌 组织中表达增加/减少，将该表达量和正常组织的表达量相比较进行 检测时，如果差异显著，则怀疑受试者肾癌转移，并且预测预后不良。
利用本发明的组合物、试剂盒或DNA芯片检测肾癌(细胞)的方 法如下：通过活组织检测等采集或从手术取出的生物组织中回收受试 者的生物组织的一部分或全部，使用选自本发明的多核苷酸组中的1 种或几种多核苷酸、其变异体或其片段检测上述生物组织中含有的基 因，测定该基因的表达量，由此预测肾癌的转移、诊断是否转移或其 程度、及/或预测肾癌患者的预后。另外，本发明的肾癌转移的预测 方法也可以例如对肾癌患者给予用于改善该疾病的治疗药时，检测、 确定或预测该疾病是否改善或改善程度。
本发明的方法，可以包括例如以下(a)、(b)及(c)步骤：
(a)步骤：使来自受试者的生物试样与本发明的组合物、试剂盒 或DNA芯片的多核苷酸接触；
(b)步骤：使用上述多核苷酸作为探针测定生物试样中靶核酸 的表达水平；
(c)步骤：根据(b)的结果，预测肾癌患者的预后、及/或、 确定在该生物试样中是否存在预测发生了转移的肾癌(细胞)。
作为本发明方法中使用的生物试样，可以举出由受试者的生物组 织例如肾组织及其周围组织、怀疑发生肾癌转移的组织等制备的试 样。具体而言，含有由该组织制备的RNA的试样、或含有由该组织制 备的多核苷酸的试样可以如下制备，即，通过活组织检测等采集或从 通过手术取出的生物组织中回收受试者的生物组织的一部分或全部， 然后按照常规方法进行制备。
此处的受试者是指哺乳动物，例如人、猴子、小鼠、大鼠等，并 无限定，优选为人。
本发明的方法，可以根据用作测定对象的生物试样的种类变更步 骤。
作为测定对象物使用RNA时，肾癌(细胞)的检测，可以包括例 如下述步骤(a)、(b)及(c)：
(a)步骤：使由受试者的生物试样制备的RNA或由该RNA转录 的互补多核苷酸(cDNA)与本发明的组合物、试剂盒或DNA芯片的 多核苷酸结合；
(b)步骤：使用上述多核苷酸作为探针，测定与该多核苷酸结 合的来自生物试样的RNA或由该RNA转录的互补多核苷酸；
(c)步骤：根据上述(b)的测定结果，确定是否存在来自预后 不良的患者的肾癌(细胞)。
为了根据本发明检测、确定或诊断发生转移的肾癌(细胞)，例 如可以使用多种杂交法。所述杂交法，例如可以使用RNA印迹法、 DNA印迹法、定量RT-PCR法、DNA芯片分析法、原位杂交法、DNA 杂交法等。
使用RNA印迹法时，通过使用本发明的诊断用组合物作为探针， 可以检测、测定RNA中的各基因是否表达或其表达水平。具体可以举 出以下方法：用放射性同位素(32P、33P、35S等)或荧光物质等标记 本发明的诊断用组合物(互补链)，使其与利用常规方法转移到尼龙 膜等上的来自受试者的生物组织的RNA杂交，然后用放射线检测器 (可以举出BAS-1800II Fuji Photo Film株式会社等)或荧光检测器 (例如STORM860，Amersham Bioscience公司等)检测、测定形成的 诊断用组合物(DNA)和RNA的双链中的来自诊断用组合物的标记物 (放射性同位素或荧光物质)的信号。
使用定量RT-PCR法时，通过使用本发明的上述诊断用组合物作 为引物，可以检测、测定RNA中的基因是否表达或其表达水平。具体 可以举出以下方法：按照常规方法由来自受试者的生物组织的RNA制 备cDNA，为了能以该cDNA为模板扩增各靶基因区域，使由本发明的 诊断用组合物制备的1对引物(由与上述cDNA结合的正链和反链组 成)与cDNA杂交，按照常规方法进行PCR法，检测得到的双链DNA。 作为双链DNA的检测方法，可以采用以下方法：使用预先用放射性同 位素或荧光物质标记的引物进行上述PCR的方法；用琼脂糖凝胶电泳 PCR产物，用溴乙锭等染色双链DNA进行检测的方法；将产生的双链 DNA按照常规方法转移到尼龙膜等上，以标记的诊断用组合物为探针 与其杂交，进行检测的方法。
使用DNA阵列分析时，使用将本发明的上述诊断用组合物作为 DNA探针(单链或双链)结合到基板上制成的DNA芯片。将基因在基 板上固定化得到的物质通常称为DNA芯片及DNA阵列，DNA阵列包 括DNA宏阵列和DNA微阵列，本说明书中称为DNA芯片时，即为含 有该DNA阵列的物质。
杂交条件没有限定，例如，包括在30℃～50℃下，在3～4×SSC、 0.1～0.5％SDS中杂交1～24小时，较优选在40℃～45℃下，在3.4×SSC、 0.3％SDS中杂交1～24小时，然后进行清洗。作为清洗条件，例如可以 举出利用含有2×SSC和0.1％SDS的溶液、及1×SSC溶液、0.2×SSC溶 液在室温下连续清洗等条件。此处，1×SSC是含有150mM氯化钠及 15mM柠檬酸钠的水溶液(pH7.2)。互补链优选为即使在上述条件下 进行清洗仍能保持与作为对象的正链杂交的状态的链。作为上述互补 链，具体可以举出由与作为对象的正链的碱基序列具有完全互补关系 的碱基序列组成的链、以及由与该链具有至少80％同源性的碱基序列 构成的链。
作为以来自本发明的组合物或试剂盒的多核苷酸片段为引物进 行PCR时的严格的杂交条件的例子，例如可以举出使用组成为10mM Tris-HCl(pH8.3)、50mM KCL、1～2mM MgCl2等的PCR缓冲液， 在由该引物序列计算的Tm-5～10℃下处理15秒～1分钟左右等。作为 上述Tm的计算方法，可以举出Tm＝2×(腺嘌呤残基数+胸腺嘧啶残 基数)+4×(鸟嘌呤残基数+胞嘧啶残基数)等。
上述杂交的“严格条件”的其它例子，记载于例如Sambrook，J.& Russel，D.著，Molecular Cloning，A LABORATORY MANUAL、Cold Spring Harbor Laboratory Press、2001年1月15日出版，第1卷7.42～7.45， 第2卷8.9～8.17等中，可以在本发明中使用。
另外，本发明还提供预测肾癌患者的预后的方法、及/或者确定 生物试样中是否含有预测转移的肾癌细胞的方法，该方法使用上述I 组及/或II组中的1种或几种探针、或本发明的组合物、试剂盒、DNA 芯片或它们的组合，测定来自受试者的生物试样中的靶核酸或基因的 表达量，以支持向量机(SVM，support vector machine)作为辨别式 进行判断，所述支持向量机(SVM)以来自预后良好的患者的肾癌组 织中的和来自预后不良的患者的肾癌组织中的基因表达量作为训练 样本。
根据本发明的实施方案，本发明的方法包括以下步骤：第1步骤， 使用本发明的组合物、试剂盒、DNA芯片、或它们的组合，体外测定 多个生物试样中的靶核酸的表达量(也称为表达水平)，所述多个生 物试样是已知来自预后良好的患者的含有肾癌细胞的组织、或来自预 后不良的患者的肾癌细胞的组织；第2步骤，以上述第1步骤得到的该 靶核酸的表达量的测定值为训练样本，制作辨别式(支持向量机)； 第3步骤，与第1步骤相同地体外测定来自受试者的生物试样中的该靶 核酸的表达量；第4步骤，将第3步骤得到的该靶乙酸的表达量的测定 值代入上述第2步骤中所得的辨别式中，根据由该辨别式得到的结果， 预测肾癌患者的预后及/或生物试样中不含预测转移的肾癌细胞、及 /或含有预测转移的肾癌细胞，此处，该靶核酸是能够通过该组合物、 试剂盒或DNA芯片中所含的多核苷酸、其变异体或其片段检测的物 质。
或者，本发明的方法，例如包括下述步骤(a)、(b)及(c)：
(a)步骤：使用本发明的诊断(检测)用组合物、试剂盒或DNA 芯片，测定生物试样中的靶基因的表达量，所述生物试样是已知的来 自预后良好的患者的含有肾癌细胞的组织或来自预后不良的患者的 含有肾癌细胞的组织的试样；
(b)步骤：将(a)测定的表达量的测定值代入下述等式1～5的 式中，制作称为SVM的辨别式；
(c)步骤：使用本发明的诊断(检测)用组合物、试剂盒或DNA 芯片，测定来自受试者的生物试样中的该靶基因的表达量，将其代入 (b)中制作的辨别式中，根据所得的结果，预测肾癌患者的预后、 及/或确定该生物试样中是否含有已转移的肾癌细胞。
SVM是为了解决二级分类问题而制作的，是1995年由AT&T的 V.Vapnik(The Nature of Statistical Leaning Theory、Springer、1995年 出版)基于统计学习理论的框架提出的学习机。SVM是一种线性辨识 器，但通过组合后述的核函数(Kernel)，能够解决非线性问题。针 对不同级别的训练样本，在辨识上述训练样本的多个超平面中，将该 超平面与训练样本的最小距离变得最大的超平面作为辨识面，由此能 最准确地辨识新给予的试样属于哪一个级别。
SVM只能解决线性问题，但作为用于解决本质上为非线性问题的 方法，已知将特征向量非线性地转换成高维，在该高维空间内进行线 性辨识的方法。使用该方法，与在原空间使用非线性模型等效。但进 行向高维转换的绘图需要庞大的计算量，归纳能力也降低。SVM中， 辨识函数仅依赖输入图案的内积，如果能计算内积，则能构建最优辨 识函数。非线性地绘制的空间中的二个要素的内积仅由各自原来的空 间的输入表示的式子称为核函数，一边在高维空间中绘制，一边避免 在实际绘制的空间中的特征的计算，仅由核函数的计算构建最优辨识 函数，即辨别式(“统计科学的前沿6图案识别与学习的统计学”p.107 -138、麻生英树、津田宏治、村田升著、岩波书店、东京、日本、 2003年4月11日出版)。
本发明的方法中能够使用的辨别式的计算例如下所示。
为了确定SVM，可以以生物试样中的靶基因的表达量作为训练样 本，按照以下步骤确定辨识函数的常数，所述生物试样是已知来自预 后良好的患者的含有肾癌细胞的组织或来自预后不良的患者的肾癌 组织的试样。
训练样本xi属于被分类为(+、-)的来自预后良好的患者的含有 肾癌细胞的组织或来自预后不良的患者的肾癌组织中的任一种。可以 用超平面线性分离上述训练样本时，辨识函数例如为下式。
[等式1]
(此处，w表示加权系数、b表示非线性常数(bias constant)、x 表示样本变量。)
但是，该函数存在限制条件：
[等式2]
yi(wTxi+b)≥1-ξi
ξi≥0，i＝1，…，n
(此处，T表示内积、y表示样本的类别、ζ表示松弛变量。)
所以，通过使用拉格朗日(Lagurange)未定乘子法，可以回归到 使用了拉格朗日乘子α的下述最优化问题。
[等式3]
此处，
[等式4]
(此处，C表示通过实验确定的限制条件参数。)
如果解决了该问题，则能够最终得到下式，
[等式5]
从而能毫无疑义地得到辨识函数。通过将新的生物试样(不知道 是否含有肾癌细胞发生了转移的组织的表达基因量)的x代入该函数， 能够分类f(x)(即+或-)，从而判断生物试样属于哪一类(即、 来自预后良好的患者的含有肾癌细胞的组织或来自预后不良的患者 的含有肾癌细胞的组织)。
如上所示，为了制作用于进行未知试样分类的SVM判定式，必需 有二组训练样本。在本发明的情况下，该训练样本例如是以下二组， 即，与“由来自预后良好的肾癌患者的肾癌组织得到的表达基因(基 因x1，x2，..xi，...xn)”的各患者对应的组、以及与“由来自预后不 良的肾癌患者的肾癌组织得到的表达基因(基因x1，x2，..xi，...xn)” 的各患者对应的组。对上述各组分别测定的表达基因数(n)因实验 设计的不同而各种各样，但对于各基因，无论在哪一个实验中，在二 组间都可以观察到存在明显差别的情况和差别比较小或无差别的情 况。为了提高SVM辨别式的精度，要求作为训练样本的二组样本之间 存在显著差异，所以，必须从基因组中仅提取在二组间表达量存在差 别的基因加以利用。
如上所述，作为提取表达量在二组间存在差别的基因的方法，可 以利用作为检测平均值的差的参数分析的t-检验、作为非参数分析的 Mann-Whitney的U检验等。作为利用生存分析法的方法，有采用Log -rank检定或Wilcoxon检定分析通过Kaplan-Meier法绘制的生存曲 线的方法等。另外，生存曲线作为回归模型处理、且用Cox比例风险 模型分析的方法，用于推测某变量是否与生存相关，特别有用。即、 Cox比例风险模型表示，对于采用Kaplan-Meier法对在某范围内分类 的患者组绘制的多个生存曲线，其各变量描述回归模型的充分性。
另外，在本发明的方法中，例如使用选自以上述序列号1～10、 12～20、22～47为基础的1种或几种上述多核苷酸及以上述序列号11、 21、48～50为基础的1种或几种多核苷酸中的任意组合，且上述50种 靶基因的表达量在与来自预后良好的患者的含有肾癌细胞的组织和 来自预后不良的患者的含有肾癌细胞的组织之间均具有显著差异，以 在来自预后不良的患者的含有肾癌细胞的组织中表达变化为指标，测 定上述50种基因的表达量，由此，能以85％以上、89％以上、90％以 上、优选92％以上、较优选93％以上、更优选94％以上的概率，预测 肾癌患者的预后、及/或发现肾癌转移(图2)。
进而，本发明提供一种预测肾癌的预后、或者检测、确定或预测 肾癌转移的方法，该方法使用针对下述多肽的1种或几种抗体或其片 段，体外测定来自预后良好的患者的含有肾癌细胞的组织和来自预后 不良的患者的含有肾癌细胞的组织中该多肽的表达量、或者血液中该 多肽的水平(或存在量)，所述多肽是由上述50种基因(即、与序列 号1～50相当)或其片段(例如、与序列号51～100相当)编码的多肽、 例如由序列号101～150表示的氨基酸序列构成的多肽。
本发明还提供一种检测、确定或预测肾癌的方法，所述方法使用 针对下述多肽的1种或几种、例如2种以上、3种以上、5种以上至全部 的抗体或其片段，体外测定肾癌组织和非癌组织中该多肽的表达量、 或者血液中该多肽的水平(或存在量)，所述多肽是由上述47种多肽 (即、与序列号151～160、191、序列号161～190、192～197相当) 或其片段编码的多肽。
具体而言，上述测定可以通过免疫学方法进行。
作为免疫学测定方法，例如可以举出酶免疫测定法(ELISA、EIA)、 荧光免疫测定法、放射免疫测定法(RIA)、发光免疫测定法、免疫 比浊法、乳胶凝集反应、乳胶比浊法、红细胞凝集反应、颗粒凝集反 应或蛋白质印迹法。
上述方法通过使用了标记的免疫测定法进行时，可以在将本发明 的抗体、或试样中的成分固定化后，进行其免疫学反应。
作为固相载体，可以使用由聚苯乙烯、聚碳酸酯、聚乙烯基甲苯、 聚丙烯、聚乙烯、聚氯乙烯、尼龙、聚甲基丙烯酸酯、乳胶、明胶、 琼脂糖、纤维素、琼脂糖凝胶、玻璃、金属、陶瓷或磁性体等材料组 成的微珠、微量培养板、试管、棒(stick)或试验片等形状的不溶性 载体。
可以通过物理吸附法、化学结合法或并用两种方法等公知的方 法，使固相载体和本发明的抗体或试样成分结合，进行固定化。
本发明中，为了容易地检测本发明的抗体与试样中的靶多肽的反 应，通过标记本发明的抗体直接检测该反应，或通过使用标记二抗间 接检测该反应。本发明的检测方法，从灵敏度方面考虑，优选使用后 者的间接检测(例如，夹心法等)。
作为标记物质，使用酶免疫测定法时，可以使用过氧化物酶 (POD)、碱性磷酸酶、β-半乳糖苷酶、脲酶、过氧化氢酶、葡萄 糖氧化酶、乳酸脱氢酶、淀粉酶或生物素-抗生物素蛋白复合体等； 使用荧光免疫测定法时，可以使用异硫氰酸荧光素、四甲基罗丹明异 硫氰酸盐、取代异硫氰酸罗丹明、二氯三嗪异硫氰酸盐、Alexa或 AlexaFluoro等荧光性物质或荧光团；使用放射免疫测定法时，可以使 用氚、碘(131I，125I，123I，121I)、磷(32P，33P)、硫(35S)、金属 类(例如68Ga，67Ga，68Ge，54Mn，99Mo，99Tc，133Xe等)等放射性同 位素。另外，使用发光免疫测定法时，可以使用NADH-、FMNH2 -、萤光素酶类、鲁米诺-过氧化氢-POD类、吖啶酯类或二氧杂环 丁烷化合物类等。
另外，根据需要，也可以使用抗生物素蛋白-生物素系统或链霉 抗生物素蛋白-生物素系统，此种情况下，例如生物素也可与本发明 的抗体或其片段结合。
作为标记物质和抗体的结合方法，在使用酶免疫测定法时，可以 使用戊二醛法、马来酰亚胺法、吡啶基二硫化物法或高碘酸法等公知 方法；在使用放射免疫测定法时，可以使用氯胺T法、Bolton-Hunter 法等公知方法。测定操作方法可以通过公知的方法(Current protocols in Protein Sciences、1995年，John Wiley & Sons Inc.、Current protocols in Immunology、2001年，John Wiley & Sons Inc.)进行。例如，直接标记 本发明的抗体时，将试样中的成分固定化，使其与标记的本发明的抗 体接触，形成标记多肽和本发明的抗体的复合体。然后将未结合的标 记抗体洗涤分离，可以由结合的标记抗体量或未结合的标记抗体量测 定试样中的靶多肽的量。
另外，使用例如标记二抗时，使本发明的抗体与试样反应(一次 反应)，再与标记二抗反应(二次反应)。一次反应和二次反应可以 以相反的顺序进行，也可以同时进行，还可以错开时间进行。通过一 次反应及二次反应，形成固定化的靶多肽-本发明的抗体-标记二抗 的复合体、或固定化的本发明的抗体-靶多肽-标记二抗的复合体。 然后洗涤分离未结合的标记二抗，可以通过结合的标记二抗量或未结 合的标记二抗量测定试样中的靶多肽的量。
具体而言，使用酶免疫测定法时，在标记酶的最适条件下使其与 底物反应，通过光学方法等测定反应生成物的量。使用荧光免疫测定 法时，测定由荧光物质标记产生的荧光强度，使用放射免疫测定法时， 测定由放射性物质标记产生的放射能量。使用发光免疫测定法时，测 定由发光反应体系产生的发光量。
本发明的方法中，通过采用光学方法测定或者肉眼观测其透射光 或散射光的测定方法来测定免疫比浊法、乳胶凝聚反应、乳胶比浊法、 红细胞凝集反应或颗粒凝集反应等中免疫复合体凝集物的生成，此 时，作为溶剂可以使用磷酸缓冲液、甘氨酸缓冲液、Tris缓冲液或 Good’s缓冲液等，还可以在反应体系中含有聚乙二醇等反应促进剂或 非特异性反应抑制剂。
上述抗体或片段包括多克隆抗体、单克隆抗体、合成抗体、重组 抗体、多特异性抗体(包括双特异性抗体)、单链抗体、Fab片段、F (ab’)2片段等。多克隆抗体可以通过与结合有纯化多肽的亲和柱结 合的所谓吸附法，作为特异性抗体进行制备。
测定方法可以包括以下步骤：使被惯用的酶或荧光团标记的抗体 或片段与组织切片或匀浆化的组织或者体液(例如血液、血清、血浆、 尿等)接触的步骤、定性或定量测定抗原-抗体复合体的步骤。可以 通过以下方法进行检测：例如，利用免疫电子显微镜测定靶多肽的存 在和水平的方法、利用ELISA或荧光抗体法等惯用方法测定靶多肽的 水平的方法等，由此，不仅能够检测肾癌，而且在来自预后良好的患 者的含有肾癌细胞的组织或来自预后不良的患者的肾癌组织中的靶 多肽的表达量减少时，或者与来自预后良好的患者的患有肾癌的受试 者相比，来自预后不良的患者的患有肾癌的受试者血液中该多肽的水 平显著变化时，能够确定预后不良、及/或肾癌转移。换言之，上述 多肽的表达量或水平，与正常值相比具有显著变化时，可以诊断为肾 癌、或者、确定预后不良及/或为已发生转移的肾癌。此处，所谓显 著是指有统计学意义。
实施例
通过以下实施例进一步具体地说明本发明。但是，本发明的范围 并不限定于这些实施例。
<实施例1>
(1)实验者的临床病理学观察
从取得知情同意的进行肾癌切除手术的31名日本肾癌患者得到 组织。对切除的组织片进行肉眼及/或病理组织学观察，判断肾癌组织 后立即冷冻，于液氮中保存。
(2)总RNA提取和cDNA的制备
作为试样，使用肾癌患者的肾组织中肾癌病变部的组织。使用 Trizol试剂(Invitrogen社)，按照该公司推荐的操作手册，由各组织 制备总RNA。
并用寡聚(dT)引物及随机九聚物，使用CyScribe First-Strand cDNA Labeling试剂盒(GE Healthcare公司，日本)，按照制造商推 荐的操作手册，对由上述方法得到的总RNA 1μg进行逆转录反应。在 来自肾癌组织的总RNA中添加Cy3-dUTP(GE Healthcare公司)，在 参考总RNA(Stratagene公司)中添加Cy5-dUTP(GE Healthcare公 司)，按照制造商推荐的操作手册，在逆转录反应时进行cDNA的标 记。被标记的cDNA用QIA quick PCR纯化试剂盒(QIAGEN公司)纯 化后用于杂交。
(3)寡DNA微阵列的制作
作为寡DNA微阵列，使用根据Affymetrix公司GeneChipTM(Human Genome U133A)及本说明书中记载的方法制作的DNA芯片。
DNA芯片的制作方法如下所示。为了确定最初载带的寡DNA的种 类，使用Affymetrix公司的GeneChipTM，进行基因的确定。GeneChipTM 的操作基于Complete GeneChipTM Instrument System等该公司规定的 顺序进行。使用Complete GeneChipTM的分析结果是提取得到有可能因 肾癌导致表达变化的基因及可以作为实验对照的基因，共计8961种。
对于提取的8961种基因，为了不引起序列的重复，分别选择序列 特异性高的位点处的含60-70个残基的序列进行合成。在 MATSUNAMI·DNA微阵列用涂层玻璃的耐DMSO的I型氨基修饰寡 DNA固定涂层(松浪硝子工业株式会社，日本)上，使用点样仪 (spotter)(GMS417 arrayer，Affymetrix公司)，在50-60％湿度环 境中点样合成寡DNA，所述合成寡DNA溶解在稀释至4倍的溶液I (TakaraBio公司，日本)中，浓度为30μM，含有序列号21-40的寡 DNA、并由8961种的60或70mer组成。
(4)杂交
在反义寡聚混合物(cocktail)(QIAGEN公司)中溶解1μg标记 的cDNA，将得到的溶液排列到载有被覆Gap的玻璃(松浪硝子工业公 司)的DNA芯片上，在42℃下杂交16小时。杂交结束后，依次用2× SSC/0.1％SDS、1×SSC、0.2×SSC清洗DNA芯片。
(5)基因表达量的测定
使用Agilent微阵列扫描仪(Agilent公司)扫描利用上述方法进行 杂交的DNA芯片，获得图像，将荧光强度转变为数值。参考Speed T. 著“Statistical analysis of gene expression microarray data”Chapman &Hall/CRC、及Causton H.C.等著“A beginner’s guide Microarray gene expression data analysis” Blackwell publishing进行统计学处理。即， 将从杂交后的图像分析得到的数据分别取对数值，进行整体最佳化 (global normalization)，并根据LOWESS(局部加权回归散点修匀 法(locally weighted scatterplot smoother))进行平滑化，通过MAD 缩放处理，进行数值校正。
(6)预测评分系统
此处，研究全部患者的各种临床信息，进行生存分析，探讨临床 信息不同是否会导致生存年数的差异。作为其一例如下，分成两组， 即手术时诊断出已转移至肾脏以外器官的患者组和未诊断出发生转 移的患者组，对各组进行生存分析，采用Kaplan-Meier法作图(图1)。 此时，在于手术时诊断出已转移至肾脏以外器官的患者组和未诊断出 发生转移的患者组间，采用使用Log-rank法的检定可见生存曲线具 有显著差异(p＜0.05)。此结果表明，两患者组的预后不同，诊断出 发生转移的患者的预后较差，未诊断出发生转移的患者的预后良好。 因此，进一步通过Cox比例风险模型法探讨各表达基因对按是否转移 分类的患者组的预后、即对生存曲线模型的影响，探讨基因表达量和 生存曲线的适合度的显著性。结果，以术后的生存曲线为指标，可以 得到321种对生存显著有利的表达基因、164种对生存不利的表达基因 (上述表1)。因此，利用上述基因，能够检测肾癌患者的预后、及 /或肾癌是否转移。
使用上述基因，制作使用搭载在Genomic Profiler(三井信息开发、 日本)上的SVM的辨别式。根据此辨别式，对全部31例的数据进行数 据预测。以全部检体为对象进行分析，以手术后5年时间内的生存为 指标，比较来自预后良好的患者的肾癌病变部和来自预后不良的患者 的肾癌病变部，使用认为有利于生存的排序高的表达基因的数据进行 分析，此时，通过分析使用序列号1～19及48的多核苷酸测定的基因 表达，能够以96％以上的概率预测预后良好的患者(图2)。
另一方面，以全部检体为对象进行分析，以手术后5年内的生存 为指标，比较来自预后良好的患者的肾癌病变部和来自预后不良的患 者的肾癌病变部，使用认为不利于生存的排序高的表达基因的数据进 行分析，此时，通过分析使用序列号20～47、49及50的多核苷酸测定 的基因表达，由此能够以87％以上的概率预测预后不良的患者(图2)。
需要说明的是，除上述使用的探针以外的本发明的其它探针也可 以同样地用于肾癌患者预后的预测。
在上述预后的确定中，同时针对1个受试组织的基因表达量套用 上述2个识别来自预后良好的患者的肾癌组织的SVM和识别来自预后 不良的患者的肾癌组织的SVM，进行分析。
结果，针对某一受试组织，当2个识别式同时得到为来自预后良 好的患者的肾癌组织的结果时、或当2个识别式同时得到为来自预后 不良的患者的肾癌组织的结果时，各诊断的准确度显著高于根据现有 的通过1个辨别式进行诊断的方法。
<实施例2>
(1)健康人及肾癌患者血浆的蛋白质鉴定
在肾癌切除手术前、及肾癌切除手术1个月后的健康状态下，由5 名50～70岁日本肾癌患者分别得到添加EDTA的血浆成分。
用孔径0.22μm的过滤器过滤血浆，除去杂质物质，进行调整，使 蛋白质浓度为50mg/mL。进一步将该血浆注入到25mM碳酸氢铵溶液 (pH8.0)中进行稀释，使浓度为12.5mg/mL，用中空纤维过滤器(东 丽，日本)进行分子量截留。用ProteomeLab(注册商标)PF2D System (Beckman Coulter公司)反相色谱将截留后的血浆样品(总量1.8mL、 含有最多250μg的蛋白质)分离成7个馏分，冻干后，再溶解于100μL 25mM碳酸氢铵溶液(pH8.0)。将该样品用蛋白质的五十分之一的量 的胰蛋白酶在37℃下消化2～3小时，进行肽化。再利用离子交换柱 (KYA Technologies，日本)将各馏分的肽分离成4个馏分。
将上述各馏分进一步用反相柱(KYA Technologies)分馏，用在 线连接的质谱Q-TOF Ultima(Micromass公司)，通过分析扫描模式 (survey scan mode)对洗脱的肽进行测定。通过用蛋白质鉴定软件 MASCOT(Matrix Science)分析上述测定数据，进行彻底的蛋白质鉴 定。结果从手术前、手术后的所有血浆成分中，均能够鉴定到MASCOT 分数在40以上(鉴定肽数2个以上)的约3500种蛋白质。
(2)肾癌患者的肾癌切除手术前及手术后的血浆蛋白质表达比 较
在肾癌切除手术前及手术后，对上述实施例2(1)中鉴定的血浆 蛋白质进行比较。找到了手术后未检测到表达、手术前在6名中有4名 以上检测到表达的蛋白质。上述蛋白质为上述表2所示的序列号151～ 160、191表示的多肽，表明其作为所谓肾癌标记物在肾癌的检测中有 用。在各患者中的表达频率如表2所示。在接受肾癌切除手术前的患 者中，6名中有4名以上能够检测到表达(以+表示)(表4)。
所以，可以通过使用例如上述多肽中的至少1种的特异抗体测定 该多肽的存在或量来检测肾癌。
[表4]
序列号 蛋白质序号 基因名 患者1 患者2 患者3 患者4 患者5 患者6 151 P54646 AAK2 - + + + + + 152 Q8IW52 SLK4 - - + + + + 153 Q8TC36 SP4L - + - + + + 154 Q96SZ6 C5P1 + - + + - + 155 Q16739 CEGT + + + + - - 156 Q92185 SI8A + + - - + + 157 P13861 KAP2 + + - + - + 158 O60825 F262 + + - + + - 159 Q99832 TCPH - + + - + + 160 P29992 GB11 + - + + + 191 Q9H423 CT67 + - + - + +
<实施例3>
(1)健康人及肾癌患者血浆的蛋白质鉴定
在肾癌切除手术前、及肾癌切除手术1个月后的健康状态下由7名 50～70岁日本肾癌患者分别获取添加EDTA的血浆成分。
用孔径0.22μm的过滤器过滤血浆，除去杂质物质，进行调整，使 蛋白质浓度为50mg/mL。进一步将该血浆注入到25mM碳酸氢铵溶液 (pH8.0)中进行稀释，使浓度为12.5mg/mL，用中空纤维过滤器(东 丽，日本)进行分子量截留。用ProteomeLab(注册商标)PF2D System (Beckman Coulter公司)反相色谱将截留后的血浆样品(总量1.8mL、 含有最多250μg的蛋白质)分离成7个馏分，冻干后，再溶解于100μL 25mM碳酸氢铵溶液(pH8.0)。将该样品用蛋白质的五十分之一的量 的胰蛋白酶在37℃下消化2～3小时，进行肽化。再利用离子交换柱 (KYA Technologies，日本)将各馏分的肽分离成4个馏分。
将上述各馏分进一步用反相柱(KYA Technologies)分馏，用在 线连接的质谱Q-TOF Ultima(Micromass公司)，通过分析扫描模式 (survey scan mode)对洗脱的肽进行测定。通过用蛋白质鉴定软件 MASCOT(Matrix Science)分析上述测定数据，进行彻底的蛋白质鉴 定。结果从手术前、手术后的所有血浆成分中，均能够鉴定到MASCOT 分数在40以上(鉴定肽数2个以上)的约3500种蛋白质。
(2)肾癌患者在肾癌切除手术前及手术后的血浆蛋白质表达比 较
在肾癌切除手术前及手术后之间，对上述实施例3(1)中鉴定的 血浆蛋白质进行比较。找到手术后未检测到表达、手术前在7名中有3 名以上检测到表达的蛋白质。上述蛋白质为上述表1所示的序列号 161～182、192、193表示的多肽，表明其作为所谓肾癌标记物在肾癌 的检测中有用。各患者中的表达频率如表5所示。在接受肾癌切除手 术前的患者中，7名中有3名以上检测到上述蛋白质的表达(以+表 示)。
所以，可以针对上述多肽的至少1种、优选至少3～5种，例如通 过使用其特异抗体，测定该多肽的存在或量来检测肾癌。
[表5]
序列号 蛋白质序号 基因名 患者 1 患者 2 患者 3 患者 4 患者 5 患者 6 患者 7 161 Q16671 AMHR2 - - + + - + - 162 O95236 APOL3 + - + - - + - 163 Q8WXF8 DEDD2 - - - + + + - 164 P07686 HEXB + - - + - - + 165 P61978 HNRPK - - + + + - - 166 P52294 KPNA1 - - + + - - + 167 Q14847 LASP1 - + - - + + - 168 O43766 LIAS - - + - + + - 169 Q8TD91 MAGEC3 - + - + - - + 170 Q14934 NFATC4 + + + - - - - 171 Q96PB7 OLFM3 + - - + - - + 172 Q9H1D9 POLR3F + - + - + - - 173 NP_066955 PPP3CB + - - - - + + 174 Q15637 SF1 + + - - - - + 175 Q9UI40 SLC24A2 + + + - - - - 176 O43511 SLC26A4 + + - + - - - 177 P46721 SLCO1A2 - + - + + - + 178 P07951 TPM2 - - - + + + - 179 Q9Y5K5 UCHL5 - + + - + - - 180 Q16880 UGT8 + + - - + - - 181 P52738 ZNF140 + - + - - - + 182 Q96GC6 ZNF274 + + + + - - - 192 P08253 MMP2 - + - + + + - 193 P26842 TNFRSF7 + + - + - + -
(3)肾癌患者在肾癌切除手术前及手术后的血浆蛋白质表达比较
分别在肾癌切除手术前及手术后比较7名患者的上述(1)中鉴定 的血浆蛋白质。在各个人中找到与同一人相比在手术后未检测到表 达、手术前检测到表达的肾癌特异性蛋白质。其中，在7名患者中的5 名中共同发现的蛋白质如表6所示。上述蛋白质为上述表6所示的序列 号183～190、194～197表示的多肽，表明其作为所谓肾癌标记物在肾 癌的检测中有用。
[表6]
序列号 蛋白质序号 基因名 患者 1 患者 2 患者 3 患者 4 患者 5 患者 6 患者 7 183 Q9UJV3 MID2 + + + + - - + 184 Q05469 LIPE + + - + - + + 185 Q9UBN7 HDAC6 - + + + + + + 186 Q99798 ACO2 + + + - + - + 187 P51693 APLP1 + - + + - + + 188 P49757 NUMB + + + + - + - 189 Q14155 ARHGEF7 + - - + + + + 190 P50148 GNAQ + - - + + + + 194 O95263 PDE8B - + + + + + - 195 O75955 FLOT1 + + - + + + + 196 P06127 CD5 + + + - + + - 197 Q16610 ECM1 + + - + + + -
产业上的可利用性
根据本发明，能够提供特异性、灵敏度优良的用于肾癌的检测、 诊断、转移预测及/或肾癌患者预后预测的组合物、试剂盒、DNA芯 片、及方法，因此，本发明特别是在制药及医药产业中是有用的。
专利文献1：国际公开第2005/024603号说明书
专利文献2：国际公开第2004/042077号说明书
专利文献3：国际公开第2004/048933号说明书
专利文献4：美国专利第6303765号说明书
专利文献5：特表2005-520536
专利文献6：特表2005-507997
专利文献7：国际公开第2002/06339号说明书
专利文献8：特表2004-518402
非专利文献1：Latif，F.等，Science、1993年、第260卷、p.1317 -1320
非专利文献2：Maxwell，P.等，Nature、1999年、第399卷、p.271 -275
非专利文献3：Lein，M.等，International Journal of Cancer、2000 年、第85卷、p.801-804
非专利文献4：Nakatsuji，T.、Clinical and Experimental Medicine、 2003年、第2卷、p.192-196
非专利文献5：Nagase，Y.等，日本泌尿器科学会杂志、1991年、 第82卷、p.1781-1789
非专利文献6：Miyake，H.等，1996年、Cancer Research、第56 卷、p.2440-2445
非专利文献7：Kitagawa，Y.等，1999年、Journal of Urology、第 162卷、p.905-909
非专利文献8：Freeman，M.R.等，1989年、Cancer Research、第 49卷、p.6221-6225
序列表
<110>东丽株式会社
国立大学法人京都大学
<120>用于肾癌诊断、肾癌患者预后预测的组合物及方法
<130>PH-2870-PCT
<140>PCT/JP2006/317380
<141>2006-09-01
<150>JP 2005-255499
<151>2005-09-02
<150>JP 2005-318589
<151>2005-11-01
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agattggagg ggtgacattg gaagctgtcc aggaaaaaga aaatggaact ggggagcaga 480
aggcctacgc aagagggcgg gacagacagg acttgtgact agtagctctg gactgaggaa 540
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ctggctagtc atgtgacctc gggtttccca agtttgaagc ccggcagtcc tttcgggggc 840
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gcggctgcg ggggcaccgg gccgcggcgc caccatggcg gtgcgacagg cgctgggccg 120
cggcctgcag ctgggtcgag cgctgctgct gcgcttcacg ggcaagcccg gccgggccta 180
cggcttgggg cggccgggcc cggcggcggg ctgtgtccgc ggggagcgtc caggctgggc 240
cgcaggaccg ggcgcggagc ctcgcagggt cgggctcggg ctccctaacc gtctccgctt 300
cttccgccag tcggtggccg ggctggcggc gcggttgcag cggcagttcg tggtgcgggc 360
ctggggctgc gcgggccctt gcggccgggc agtctttctg gccttcgggc tagggctggg 420
cctcatcgag gaaaaacagg cggagagccg gcgggcggtc tcggcctgtc aggagatcca 480
ggcaattttt acccagaaaa gcaagccggg gcctgacccg ttggacacga gacgcttgca 540
gggctttcgg ctggaggagt atctgatagg gcagtccatt ggtaagggct gcagtgctgc 600
tgtgtatgaa gccaccatgc ctacattgcc ccagaacctg gaggtgacaa agagcaccgg 660
gttgcttcca gggagaggcc caggtaccag tgcaccagga gaagggcagg agcgagctcc 720
gggggcccct gccttcccct tggccatcaa gatgatgtgg aacatctcgg caggttcctc 780
cagcgaagcc atcttgaaca caatgagcca ggagctggtc ccagcgagcc gagtggcctt 840
ggctggggag tatggagcag tcacttacag aaaatccaag agaggtccca agcaactagc 900
ccctcacccc aacatcatcc gggttctccg cgccttcacc tcttccgtgc cgctgctgcc 960
aggggccctg gtcgactacc ctgatgtgct gccctcacgc ctccaccctg aaggcctggg 1020
ccatggccgg acgctgttcc tcgttatgaa gaactatccc tgtaccctgc gccagtacct 1080
ttgtgtgaac acacccagcc cccgcctcgc cgccatgatg ctgctgcagc tgctggaagg 1140
cgtggaccat ctggttcaac agggcatcgc gcacagagac ctgaaatccg acaacatcct 1200
tggagctg gacccagacg gctgcccctg gctggtgatc gcagattttg gctgctgcct 1260
ggctgatgag agcatcggcc tgcagttgcc cttcagcagc tggtacgtgg atcggggcgg 1320
aaacggctgt ctgatggccc cagaggtgtc cacggcccgt cctggcccca gggcagtgat 1380
tgactacagc aaggctgatg cctgggcagt gggagccatc gcctatgaaa tcttcgggct 1440
tgtcaatccc ttctacggcc agggcaaggc ccaccttgaa agccgcagct accaagaggc 1500
tcagctacct gcactgcccg agtcagtgcc tccagacgtg agacagttgg tgagggcact 1560
gctccagcga gaggccagca agagaccatc tgcccgagta gccgcaaatg tgcttcatct 1620
aagcctctgg ggtgaacata ttctagccct gaagaatctg aagttagaca agatggttgg 1680
ctggctcctc caacaatcgg ccgccacttt gttggccaac aggctcacag agaagtgttg 1740
tgtggaaaca aaaatgaaga tgctctttct ggctaacctg gagtgtgaaa cgctctgcca 1800
ggcagccctc ctcctctgct catggagggc agccctgtga tgtccctgca tggagctggt 1860
gaattactaa aagaacttgg catcctctgt gtcgtgatgg tctgtgaatg gtgagggtgg 1920
gagtcaggag acaagacagc gcagagaggg ctggttagcc ggaaaaggcc tcgggcttgg 1980
caaatggaag aacttgagtg agagttcagt ctgcagtcct gtgctcacag acatctgaaa 2040
agtgaatggc caagctggtc tagtagatga ggctggactg aggaggggta ggcctgcatc 2100
cacagagagg atccaggcca aggcactggc tgtcagtggc agagtttggc tgtgaccttt 2160
gcccctaaca cgaggaactc gtttgaaggg ggcagcgtag catgtctgat ttgccacctg 2220
gatgaaggca gacatcaaca tgggtcagca cgttcagtta cgggagtggg aaattacatg 2280
aggcctgggc ctctgcgttc ccaagctgtg cgttctggac cagctactga attattaatc 2340
tcacttagcg aaagtgacgg atgagcagta agtaagtaag tgtggggatt taaacttgag 2400
ggtttccctc ctgactagcc tctcttacag gaattgtgaa atattaaatg caaatttaca 2460
actgcagatg acgtatgtgc cttgaactga atatttggct ttaagaatga ttcttatact 2520
ctgaaggtga gaatattttg tgggcaggta tcaacattgg ggaagagatt tcatgtctaa 2580
ctaactaact ttatacatga tttttaggaa gctatgccta aatcagcgtc aacatgcagt 2640
aaaggttgtc ttcaactg 2658
<210>3
<211>604
<212>DNA
<213>人
<400>3
atgcattctg caagccaccc tggggtgcag ctgagctaga catgggacgg cgagacgccc 60
agctcctggc agcgctcctc gtcctggggc tatgtgccct ggcggggagt gagaaaccct 120
ccccctgcca gtgctccagg ctgagccccc ataacaggac gaactgcggc ttccctggaa 180
tcaccagtga ccagtgtttt gacaatggat gctgtttcga ctccagtgtc actggggtcc 240
cctggtgttt ccaccccctc ccaaagcaag agtcggatca gtgcgtcatg gaggtctcag 300
accgaagaaa ctgtggctac ccgggcatca gccccgagga atgcgcctct cggaagtgct 360
gcttctccaa cttcatcttt gaagtgccct ggtgcttctt cccgaagtct gtggaagact 420
gccattacta agagaggctg gttccagagg atgcatctgg ctcaccgggt gttccgaaac 480
aaagaagaa acttcgcctt atcagcttca tacttcatga aatcctgggt tttcttaacc 540
atcttttcct cattttcaat ggtttaacat ataatttctt taaataaaac ccttaaaatc 600
tgct 604
<210>4
<211>2977
<212>DNA
<213>人
<400>4
gggagagtcg gaagcgcggc ggccgcggag ccctgcgagt aggcagcgtt gggcccatgc 60
aggacgcgga gaacgtggcg gtgcccgagg cggccgagga gcgcgccgag cccggccagc 120
agcagccggc cgccgagccg ccgccagccg aggggctgct gcggcccgcg gggcccggcg 180
ctccggaggc cgcggggacc gaggcctcca gtgaggaggt ggggatcgcg gaggccgggc 240
cggagtccga ggtgaggacc gagccggcgg ccgaggcaga ggcggcctcc ggcccgtccg 300
agtcgccctc gccgccggcc gccgaggagc tgcccgggtc gcatgctgag ccccctgtcc 360
cggcacaggg cgaggcccca ggagagcagg ctcgggacga gcgctccgac agccgggccc 420
aggcggtgtc cgaggacgcg ggaggaaacg agggcagagc ggccgaggcc gaaccccggg 480
cgctggagaa cggcgacgcg gacgagccct ccttcagcga ccccgaggac ttcgtggacg 540
acgtgagcga ggaagaatta ctgggagatg tactcaaaga tcggccccag gaagcagatg 600
gaatcgattc ggtgattgta gtggacaatg tccctcaggt gggacccgac cgacttgaga 660
ctcaaaaa tgtcatccac aagatctttt ccaagtttgg gaaaatcaca aatgattttt 720
atcctgaaga ggatgggaag acaaaagggt atattttcct ggagtacgcg tcccctgccc 780
acgctgtgga tgctgtgaag aacgccgacg gctacaagct tgacaagcag cacacattcc 840
gggtcaacct ctttacggat tttgacaagt atatgacgat cagtgacgag tgggatattc 900
cagagaaaca gcctttcaaa gacctgggga acttacgtta ctggcttgaa gaggcagaat 960
gcagagatca gtacagtgtg atttttgaga gtggagaccg cacttccata ttctggaatg 1020
acgtaaaaga ccctgtctca attgaagaaa gagcgagatg gacagagacg tatgtgcgtt 1080
ggtctcctaa gggcacctac ctggctacct ttcatcaaag aggcattgct ctatgggggg 1140
gagagaaatt caagcaaatt cagagattca gccaccaagg ggttcagctt attgacttct 1200
caccttgtga aaggtacctg gtgaccttta gccccctgat ggacacgcag gatgaccctc 1260
aggccataat catctgggac atccttacgg ggcacaagaa gaggggtttt cactgtgaga 1320
gctcagccca ttggcctatt tttaagtgga gccatgatgg caaattcttt gccagaatga 1380
ccctggatac gcttagcatc tatgaaactc cttctatggg tcttttggac aagaagagtt 1440
tgaagatctc tgggataaaa gacttttctt ggtctcctgg tggtaacata atcgccttct 1500
gggtgcctga agacaaagat attccagcca gggtaaccct gatgcagctc cctaccaggc 1560
aagagatccg agtgaggaac ctgttcaatg tggtggactg caagctccat tggcagaaga 1620
acggagacta cttgtgtgtg aaagtagata ggactccgaa aggcacccag ggtgttgtca 1680
caaattttga aattttccga atgagggaga aacaggtacc tgtggatgtg gtcgagatga 1740
aagaaaccat catagccttt gcctgggaac caaatggaag taagtttgct gtgctgcacg 1800
gagaggctcc gcggatatct gtgtctttct accacgtcaa aaacaacggg aagattgaac 1860
tcatcaagat gttcgacaag cagcaggcga acaccatctt ctggagcccc caaggacagt 1920
tcgtggtgtt ggcgggcctg aggagtatga acggtgcctt agcgtttgtg gacacttcgg 1980
actgcacggt catgaacatc gcagagcact acatggcttc cgacgtcgaa tgggatccta 2040
ctgggcgcta cgtcgtcacc tctgtgtcct ggtggagcca taaggtggac aacgcgtact 2100
ggctgtggac tttccaggga cgcctcctgc agaagaacaa caaggaccgc ttctgccagc 2160
tgctgtggcg gccccggcct cccacactcc tgagccagga acagatcaag caaattaaaa 2220
aggatctgaa gaaatactct aagatctttg aacagaagga tcgtttgagt cagtccaaag 2280
cctcaaagga attggtggag agaaggcgca ccatgatgga agatttccgg aagtaccgga 2340
aaatggccca ggagctctat atggagcaga aaaacgagcg cctggagttg cgaggagggg 2400
gacactga cgagctggac agcaacgtgg acgactggga agaggagacc attgagttct 2460
tcgtcactga agaaatcatt cccctcggga atcaggagtg acctggagca ctgtgcgcag 2520
ccgtgtgtgc tgtggagccg aggccgtcct gcaggaagcc gcgtgactcc cgcctcctcc 2580
ctgtgctctc tggctctgga ctgtgactgc gcctggattc tgccattgcg acacattttt 2640
gtgcctttca gcccctggtg tctgcagtgg gggatttaag gcacccgctt ccacttcttt 2700
cttgtttgga gttttctgtt ggaaccgccg gcgttggctc cgaagactta gcgacgccac 2760
tggcggcacc ttctcctgcg cccagtgatg tttccacggt gcctgtacac agccgagcag 2820
catttccgtt gaaggacttg catccccatt gcgggcagtg ctggacgtgt cccggagacc 2880
caccgggagg gcgccgccat gccttgtacc cccaccgtgc aggttgtggc cggttttctc 2940
caggttga acatggaaat aaaagcaaac ttgtatg 2977
<210>5
<211>2002
<212>DNA
<213>人
<400>5
ggtggttctt gcccgtgttg tgtgtgtgtg tgagtgagag agcgagtgag tgagtgagtg 60
agtgtgtgtg tgggggggac tcggcttgtt gttgtcggtg acttccccct ccccttcacc 120
ccttcccctc cccgccgccg ctgcagtggc cgctccctgg gccgtaggaa atgagcgata 180
acgatgacat cgaggtggag agcgacgaag agcaaccgag gtttcaatct gcggctgaca 240
aacgggctca tcataatgca ctggaacgaa aacgtaggga ccacatcaaa gacagctttc 300
acagtttgcg ggactcagtc ccatcactcc aaggagagaa ggcatcccgg gcccaaatcc 360
tagacaaagc cacagaatat atccagtata tgcgaaggaa aaaccacaca caccagcaag 420
atattgacga cctcaagcgg cagaatgctc ttctggagca gcaagtccgt gcactggaga 480
aggcgaggtc aagtgcccaa ctgcagacca actacccctc ctcagacaac agcctctaca 540
ccaacgccaa gggcagcacc atctctgcct tcgatggggg ctcggactcc agctcggagt 600
ctgagcctga agagccccaa agcaggaaga agctccggat ggaggccagc taagccactc 660
ggggcaggcc agcaataaaa actgtctgtc tccatcgtct catcctcctt tcagttcgtt 720
ggtagagccc tcagaaccat ttaagagact ctttattttt ctctttctcc cttttttttt 780
aattttta tttttacgta gaagctcttg gacaacagct ctcgttctcc ttccccattt 840
ccactgtata ttttttaatg tattcccttc agggattccc tgtccccaac aggaattttt 900
aaaccaaaac accccaactt ggcagctttt tctgtggagg acagacggcc ggccggacct 960
ctgagcacat agtgtcctgc ccaccctacc agctcctcca gccctgccgg gcacatgccc 1020
gggggacgcc tgccctgccc aggtggcctc ctggcccgcc ctcacctctg atagactttg 1080
tgaatctgaa ctgctctact ttgagaagat gaccggtttg gagtaatcag aatgaaccct 1140
cctccttttt aagggttttt tttttttcct ttttctaaaa agctatgtat cgctcctatt 1200
gaaagaccag atccttagag aagtttgtgg tataaaaagg aagtggggac agattcgcag 1260
cacagagtcg ctggcatgtt tcactcctgc ttctctcagc cagctgttta agcctgcggc 1320
gccagcctca cggagggccg tgtgacactc tcgtggtatg tatgggagat ggcagcagtg 1380
gcagcagc caccagggag tggccatttg gggttgggac agggagggtg ttttgggtgg 1440
catagaggtt ttgtattgag ggccagtgat gatgttttga tatttatttc ctgctactta 1500
aatttgaatc tgagtgaatt gtacctattt ctgatgatgt cggtcttgca aagcgacaga 1560
ttcataaagt aatgatgaaa tctttctttc ttcccgtgtg tatttctaag aaatagagcc 1620
aactgatttt gtatgtaaat accaagagca atttacctgg tactaaaccc gcaccccagt 1680
gcggaccctt cccagccctc atcccacttc ctttcctact gtcctggaac ctgtctccat 1740
tgtgtgatcc agccctggtt ctggctgtgg tcagcagatg ccagtgaagg gttttgtgtg 1800
tttaggcctc atttctttgt ctttttccta ctccgttcct ggcatttgct gatttctagt 1860
gtatactctg tagtctcagt tcgtgtttga ttccattcca tggaaataaa aagtatgttg 1920
tacatactgc cgaagaattg tcttgcaagt taaggcttcc ccctttacta taagactata 1980
aataaaaact tattttatcc tt 2002
<210>6
<211>8469
<212>DNA
<213>人
<400>6
atggcggcgg cggcgggcgg cggcagttgc cccgggcctg gctccgcgcg gggccgcttc 60
ccgggccggc cgcggggcgc cggcgggggc gggggccgcg gcggacgggg caacggggcc 120
gaaagagtgc gggtagctct gcggcgcggc ggtggcgcga cggggccggg cggagccgag 180
cggggagg acacggccct gctccgtttg ctggggctcc gccggggcct gcgccggctc 240
cgccgcctgt gggccggccc gcgggtccag cggggccggg gacggggtcg gggccggggc 300
tggggcccga gtcgaggctg cgtgccggag gaggagagca gtgacgggga atccgacgag 360
gaggagtttc agggttttca ttcagatgaa gatgtggccc ccagttccct gcgctctgcg 420
ctccgatccc agcgaggtcg agcgccccga ggtcggggtc gcaagcataa gacgaccccc 480
cttcctcctc ctcgcctagc agatgtggct cctacccccc caaagacccc tgcccggaaa 540
cggggtgagg aaggcacaga acggatggtg caggcactga ctgaacttct ccggcgggcc 600
caggcacccc aagcaccccg gagccgggca tgtgagccct ccaccccccg gcggtctcgg 660
ggacggcccc caggacggcc agcaggcccc tgcaggagga agcagcaagc agtagtggtg 720
agaagcag ctgtgacaat ccccaaacct gagcccccac ctcctgtggt tccagtgaaa 780
catcagactg gcagctggaa atgcaaggag gggcccggtc caggacctgg gacccccagg 840
cgtggaggac agtcaagccg tggaggccgt ggaggcaggg gccgcggccg aggtggtggg 900
ctcccctttg tgatcaagtt tgtttcaagg gccaaaaaag taaagatggg acaattgtcc 960
ttgggactcg aatcaggtca aggtcaaggt caacatgagg aaagttggca ggatgtcccc 1020
caaagaagag ttggatctgg acagggaggg agcccttgct ggaaaaagca ggaacagaag 1080
ctggatgacg aggaagaaga gaagaaagaa gaagaagaaa aagacaagga gggagaagag 1140
aaggaagaaa gagctgtagc tgaggagatg atgccagctg cggaaaagga agaggcaaag 1200
ctgccaccac cgcctctgac tcctccagcc ccttcacctc ctccacccct cccaccccct 1260
tcgacatctc ctccaccccc actctgccct ccaccaccac ccccagtgtc cccaccacct 1320
ctaccatccc ctccaccgcc tcctgcccaa gaggagcagg aggaatcccc tcctcctgtg 1380
gtcccagcta cgtgctccag gaagaggggc cggcctcccc tgactcccag ccagcgggcg 1440
gagcgggaag ctgctcgggc agggccagag ggcacctctc ctcccactcc aacccccagc 1500
accgccacgg gaggccctcc ggaagacagt cccaccgtgg cccccaaaag caccaccttc 1560
ctgaagaata tccggcagtt tattatgcct gtggtgagtg cccgctcctc ccgtgtcatc 1620
aagacacccc ggcgatttat ggatgaagac ccccccaaac ccccaaaggt ggaggtctca 1680
cctgtcctgc gacctcccat taccacctcc ccacctgttc cccaggagcc agcaccagtc 1740
ccctctccac cacgtgcccc aactcctcca tctaccccag ttccactccc tgagaagaga 1800
cggtccatcc taagggaacc cacatttcgc tggacctcac tgacccggga gctgccccct 1860
tcccccag cccctccacc tcccccggcc ccctccccac cccctgctcc tgccacctcc 1920
tcccggaggc ccctactcct tcgggcccct cagtttaccc caagcgaagc ccacctgaag 1980
atctacgaat cggtgcttac tcctcctcct cttggggctc ctgaagcccc tgagccagag 2040
cctcctcctg ccgatgactc tccagctgag cctgagcctc gggcagtggg ccgcaccaac 2100
cacctcagcc tgcctcgatt cgcccctgtg gtcaccactc ctgttaaggc cgaggtgtcc 2160
cctcacgggg ctccagctct gagcaacggg ccacagacac aggctcagct actgcagccc 2220
ctgcaggcct tgcaaaccca gctcctgccc caggcactac cgccaccaca gccacagctg 2280
cagccaccgc cgtcaccaca gcagatgcct cccctggaaa aagcccggat tgcgggcgtg 2340
ggttccttgc cgctgtctgg ggtagaggag aagatgttca gcctcctcaa gagagccaaa 2400
gtgcagctat tcaagatcga tcagcagcag cagcagaagg tggcagcttc catgccgctg 2460
ccctggag ggcagatgga ggaggtggcc ggggctgtca agcagatctc cgacagaggc 2520
cctgtccggt ctgaagatga gtcggtggaa gctaagagag agcggccctc aggtcccgag 2580
tcccctgtgc aaggtccccg catcaaacat gtctgccgtc atgctgctgt ggccctgggt 2640
caggcccggg ccatggtgcc tgaagatgtc cctcgcctca gtgccctccc tctccgggat 2700
cggcaggacc tcgccacaga ggatacatca tcggcgtccg agactgagag tgtcccgtca 2760
cggtcccggc ggggaaaggt ggaggcagca ggccctgggg gagaatcaga gcccacaggt 2820
tctggaggga ccctggccca cacaccccgg cgctcactgc cctcccatca cggcaagaag 2880
atgcgcatgg ctcgatgtgg acactgtcgg ggctgcctac gtgtgcagga ctgtgggtcc 2940
tgtgtcaact gcctagacaa gcccaagttt gggggcccta acaccaagaa gcagtgctgt 3000
gtataccgga agtgtgacaa aatagaggct cggaagatgg aacgactggc taaaaaaggc 3060
cggacgatag tgaagacgct gttgccctgg gattccgatg aatctcctga ggcctcccct 3120
ggtcctccag gcccacgccg gggggcggga gctggggggc cccgggagga ggtggtggcc 3180
cacccagggc ccgaggagca ggactccctc ctgcagcgca agtcagctcg gcgctgcgtc 3240
aaacagcgac cctcctatga tatcttcgag gattcggatg actcggagcc cgggggcccc 3300
cctgctcctc ggcgtcggac cccccgagaa aatgagctgc cactgccaga acctgaggag 3360
cagagccggc cccgcaaacc taccctgcag cctgtgttgc agctcaaggc ccgaaggcgc 3420
ctggacaagg atgctttggc ccctggcccc tttgcttctt ttcccaatgg ctggactgga 3480
aagcagaagt ctcccgatgg tgtgcaccgc gtccgtgtgg attttaagga ggattgtgat 3540
ttagagaacg tgtggctgat ggggggcctg agtgtgctca cctctgtgcc agggggcccc 3600
gatggtgt gcttgctgtg tgccagcaaa ggactccacg agctggtgtt ctgtcaagtc 3660
tgctgtgacc cattccaccc attctgcctg gaggaggccg agcggcccct gccccagcat 3720
cacgacacct ggtgctgccg tcgctgcaaa ttctgccacg tctgtggacg caaaggtcgt 3780
ggatccaagc acctcctgga gtgcgagcgc tgccgccatg cataccaccc ggcctgtctg 3840
gggcccagct atccaacccg ggccacgcgc aaacggcgcc actggatctg ttcagcctgt 3900
gtgcgctgta agagctgtgg ggcaactcca ggcaagaact gggacgtcga gtggtctgga 3960
gattacagcc tctgccccag gtgcacccag ctatatgaga aaggaaacta ctgcccgatc 4020
tgtacacgct gctatgaaga caacgactat gagagcaaga tgatgcagtg cgcacagtgc 4080
gatcactggg tgcatgccaa gtgcgagggg ctctcagatg aagactacga gatcctttca 4140
actgccag actcggtgct gtacacctgc ggaccgtgtg ctggggcagc gcagccccgc 4200
tggcgagagg ccctgagcgg ggccctccag gggggcctgc gccaggtgct ccagggcctg 4260
ctgagctcca aggtggtggg cccactgctg ctctgcaccc agtgtgggcc agatgggaag 4320
caactgcacc caggaccctg cggcctgcaa gctgtgagtc agcgcttcga ggatggccac 4380
tacaagtctg tgcacagctt catggaggac atggtgggca tcctcatgcg gcactcggag 4440
gagggagaga ccccggaccg ccgggctgga ggccagatga aggggctcct gctgaagctg 4500
ctagaatctg cgttcggctg gttcgacgcc cacgacccca agtactggcg acggagtacc 4560
cggctgccaa acggagtcct tcccaatgcg gtgttgcccc catccctgga tcatgtctat 4620
gcgcagtgga gacagcagga accagagacc ccagaatcag ggcagcctcc aggggatccc 4680
tcagcagcat tccagggcaa ggatccggct gccttctcac acctggagga cccccgtcag 4740
tgtgcactct gcctcaaata cggggatgca gactccaagg aggcggggcg gctcttgtac 4800
atcgggcaga acgagtggac acacgtcaac tgtgccatct ggtcggcgga agtcttcgag 4860
gagaacgacg gctccctcaa gaatgtgcat gctgctgtgg cccgagggag gcagatgcgc 4920
tgcgagctct gcctgaagcc tggcgccacg gtgggctgct gcctgtcctc ctgcctcagc 4980
aacttccact tcatgtgtgc ccgggccagc tactgcatct tccaggatga caagaaagtc 5040
ttctgccaga aacacactga tctcctggat ggcaaggaaa ttgtgaaccc cgatggtttt 5100
gatgttctcc gccgagtcta tgtggacttc gagggcatca acttcaagcg gaagttcttg 5160
acggggcttg aacccgatgc catcaacgtg ctcattggtt ccatccgcat tgactccctg 5220
ggtactctgt ctgatctctc ggactgcgag ggacggctct tccccattgg ctaccagtgc 5280
ccgtctgt actggagcac agtggatgct cggaggcgct gctggtatcg gtgccgaatt 5340
ctggagtatc ggccatgggg gccgagggaa gagccagctc acctggaggc tgcagaggag 5400
aaccagacca ttgtgcacag ccccgcccct tcctcagagc ccccaggtgg tgaggacccc 5460
ccactggaca cagatgttct tgtccctgga gctcctgagc gccactcgcc cattcagaac 5520
ctggaccctc cactgcggcc agattcaggc agcgcccctc ctccagcccc ccgttctttt 5580
tcgggggctc gaatcaaagt gcccaactac tcgccatccc ggaggccctt ggggggtgtc 5640
tcctttggcc ccctgccctc ccctggaagt ccatcttcac tgacccacca catccccaca 5700
gtgggagacc cggacttccc agctcccccc agacgttccc gtcgtcccag ccctttggct 5760
cccaggccgc ctccatcacg gtgggcctcc cctcctctaa aaacctcccc tcagctcagg 5820
gtgccccctc ctacctcagt cgtcacagcc ctcacaccta cctcagggga gctggctccc 5880
tggcccgg ccccatctcc accaccccct gaagacctgg gcccagactt cgaggacatg 5940
gaggtggtgt caggactgag tgctgctgac ctggacttcg cggccagcct gctggggact 6000
gagcccttcc aggaagagat tgtagccgct ggggccatgg ggagcagcca cgggggcccg 6060
ggggacagct ccgaggagga gtccagcccc acctcccgct acatccactt ccctgtgact 6120
gtggtgtccg cccctggtct ggcccccagc gctacccctg gagccccccg cattgaacag 6180
ctggacggcg tggacgacgg cactgacagt gaggctgagg cggtgcagca gcctcggggc 6240
cagggcacgc ctccttcggg gccaggagta gtccgggcag gggtccttgg ggctgcaggg 6300
gacagggccc ggcctcctga ggacctgcca tcggaaattg tggattttgt gttgaagaac 6360
ctagggggtc ctggggatgg aggtgctggc cctagagagg agtcactccc cccggcgcct 6420
cccctggcta atggcagcca gccctcccaa ggcctgaccg ccagcccagc tgaccccacc 6480
cgcacatttg cctggctccc aggggcccca ggggtccggg tgttaagcct tggccctgcc 6540
cctgagcccc ccaaacccgc cacatccaaa atcatacttg tcaacaagct ggggcaagta 6600
tttgtgaaga tggctgggga gggtgaacct gtcccacccc cagtgaagca gccacctttg 6660
ccccccacca tttcccccac ggctcccacc tcctggactc tgcccccagg ccccctcctc 6720
ggcgtgctgc ccgtggtcgg agtggtccgc cctgccccgc ccccgccacc ccctcccctg 6780
acgctggtgc tgagcagtgg gccagccagc ccgccccgcc aggccatccg cgtcaagagg 6840
gtgtccactt tctccggccg gtccccgcca gcacctcccc catacaaagc cccccggctg 6900
gatgaagatg gagaggcctc agaggatacc cctcaggttc cagggcttgg cagtggcggg 6960
tttagccgtg tgaggatgaa aacccccaca gtgcgtgggg tccttgacct ggatcggcct 7020
ggagcccg ctggggaaga aagtcctggg cccctccagg aacggtcccc tttgctgcca 7080
cttccggaag atggtcctcc ccaggtcccc gatggtcccc cagacctgct gcttgagtcc 7140
cagtggcacc actattcagg tgaggcttcg agctctgagg aagagcctcc atccccagat 7200
gataaagaga accaggcccc aaaacggact ggcccacatc tgcgcttcga gatcagcagt 7260
gaggatgggt tcagcgttga ggcagagagc ttggaggggg cgtggagaac tctgatcgag 7320
aaagtgcaag aggcccgagg gcatgcccga ctcagacatc tctcctttag tggaatgagt 7380
ggggcgagac tcctgggcat ccaccatgat gctgtcatct tcctggccga gcagctcccc 7440
ggagcccagc gttgccagca ctataagttc cgttaccacc agcagggaga gggccaggag 7500
gagccgcccc tgaatcccca tggggctgct cgggcagagg tctatctccg gaagtgcacc 7560
tgacatgt tcaacttcct ggcctcccag caccgggtgc tccctgaggg ggccacctgt 7620
gatgaggaag aggatgaggt gcagctcagg tcaaccagac gtgccaccag cctggagctg 7680
cccatggcca tgcgttttcg tcaccttaag aagacgtcca aagaagctgt gggtgtctac 7740
agatcagcca tccacgggcg aggcctgttc tgtaagcgca acatcgacgc gggggagatg 7800
gtcatcgagt actctggcat tgtcatccgc tcggtgttga ctgacaagcg ggagaagttc 7860
tacgatggga agggcatcgg gtgctatatg ttccgcatgg atgactttga tgtagtggac 7920
gccacgatgc atggcaatgc cgcccgcttc atcaaccact cctgtgagcc caactgcttc 7980
tctcgggtca tccacgtgga gggccagaaa cacattgtta tcttcgccct gcgccgcatc 8040
ctgcgtggtg aggagctcac ctacgactac aagttcccca tcgaggatgc cagcaacaag 8100
ctgccctgca actgtggcgc caagcgctgc cgtcggttcc ttaactgagg ccgtggctgc 8160
ccaccacgac ccctcacacc tcctgctgcc gtcgctgcca tcttgcccct agcctggggg 8220
ctccctagcc cctcccagag catctcaccc ccaccctcat gttcagggtg gatgtgggca 8280
tgcaggtgac aagggccctg cctccacccc tccagcccat ccagcaatcg ccccctttct 8340
gccctggggg cccaggatgt agatattgta caaaggtttc taaatccctt cttttctatg 8400
cactttttta tttaagaggt ggggtcccag gtgggaaccc ccccacaata aagtctgtca 8460
atgtttgga 8469
<210>7
<211>3704
<212>DNA
<213>人
cagcagcgtg ctaagaagca gtcacataaa cagcagcagg agtaggcctc ctgcttttca 60
aaagcagagt actgcagggt cgcgaaatgc aagacactca gatgtttgaa aatctcccga 120
gttgagaatg gctactgtaa aagcgtcacc aagaaactct gacgatctgg acagtcctaa 180
ctctgtgtta gcaatactta cttccggaaa attaatgcta cttcttgtag atttttgcaa 240
ataggaaacc cccttgaaga agatctcaaa ttacgccccc cacccccaaa aaaagacaaa 300
caggggagaa caaagttttg gcatgcctgc aggaacggtg gcttttttag aaactaccta 360
ggaggcagaa gctaagtgat ttgctcatgc ctcttacctg ggagtagaag gtgggaagaa 420
atggaccgag gctgtgacga gaagacaagg cacagtgcag cttggtgaag ccacacgctg 480
tgcgttct gccccctctt catgcagtgc tgcgggctgg tgcatcgccg gcgagtacgg 540
gtgtcctatg gttcggcaga ctcctacact agccgtccat ccgattccga tgtatctctg 600
gaggaggacc gggaggcagt gcgcagagaa gcggagcggc aggcccaggc acagttggaa 660
aaagcaaaga caaagcccgt tgcatttgcg gttcggacaa atgtcagcta cagtgcggcc 720
catgaagatg atgttccagt gcctggcatg gccatctcat tcgaagcaaa agattttctg 780
catgttaagg aaaaatttaa caatgactgg tggatagggc gattggtaaa agaaggctgt 840
gaaatcggat tcattccaag cccagtcaaa ctagaaaaca tgaggctgca gcatgaacag 900
agagccaagc aagggaaatt ctactccagt aaatcaggag gaaattcatc atccagtttg 960
ggtgacatag tacctagttc cagaaaatca acacctccat catctgctat agacatagat 1020
gctactggct tagatgcaga agaaaatgat attccagcaa accaccgctc ccctaaaccc 1080
agtgcaaaca gtgtaacgtc accccactcc aaagagaaaa gaatgccctt ctttaagaag 1140
acagagcaca ctcctccgta tgatgtggta ccttccatgc gaccagtggt cctagtgggc 1200
ccttctctga agggctacga ggtcacagat atgatgcaaa aagcgctgtt tgatttttta 1260
aaacacagat ttgaagggcg gatatccatc acaagggtca ccgctgacat ctcgcttgcc 1320
aaacgctcgg tattaaacaa tcccagtaag cacgcaataa tagaaagatc caacacaagg 1380
tcaagcttag cggaagttca gagtgaaatc gaaaggattt ttgaacttgc aagaacattg 1440
cagttggtgg tccttgacgc ggatacaatt aatcatccag ctcaactcag taaaacctcc 1500
ttggccccta ttatagtata tgtaaagatt tcttctccta aggttttaca aaggttaata 1560
aaatctcgag ggaaatctca agctaaacac ctcaacgtcc agatggtagc agctgataaa 1620
ggctcagt gtcctccaga gctgttcgat gtgatcttgg atgagaacca gcttgaggat 1680
gcctgtgagc accttgccga ctatctggag gcctactgga aggccaccca tcctcccagc 1740
agtagcctcc ccaaccctct ccttagccgt acattagcca cttcaagtct gcctcttagc 1800
cccaccctag cctctaattc acagggttct caaggtgatc agaggactga tcgctccgct 1860
cctatccgtt ctgcttccca agctgaagaa gaacctagtg tggaaccagt caagaaatcc 1920
cagcaccgct cttcctcctc agccccacac cacaaccatc gcagtgggac aagtcgcggc 1980
ctctccaggc aagagacatt tgactcggaa acccaggaga gtcgagactc tgcctacgta 2040
gagccaaagg aagattattc ccatgaccac gtggaccact atgcctcaca ccgtgaccac 2100
aaccacagag acgagaccca cgggagcagt gaccacagac acagggagtc ccggcaccgt 2160
cccgggacg tggatcgaga gcaggaccac aacgagtgca acaagcagcg cagccgtcat 2220
aaatccaagg atcgctactg tgaaaaggat ggagaagtga tatcaaaaaa acggaatgag 2280
gctggggagt ggaacaggga tgtttacatc ccccaatgag ttttgccctt ttgtgttttt 2340
tttttttttt ttttgaagtc ttgtataact aacagcatcc ccaaaacaaa gtctttgggg 2400
tctacactgc aatcatatgt gatctgtctt gtaatatttt gtattattgc tgttgcttga 2460
atagcaatag catggataga gtattgagat actttttctt ttgtaagtgc tacataaatt 2520
ggcctggtat ggctgcagtc ctccggttgc atactggact cttcaaaaac tgttttgggt 2580
agctgccact tgaacaaaat ctgttgccac ccaggtgatg ttagtgtttt aagaaatgta 2640
gttgatgtat ccaacaagcc agaatcagca cagataaaaa gtggaatttc ttgtttctcc 2700
agatttttaa tacgttaata cgcaggcatc tgatttgcat attcattcat ggaccactgt 2760
ttcttgcttg tacctctggc tgactaaatt tggggacaga ttcagtcttg ccttacacaa 2820
aggggatcat aaagttagaa tctattttct atgtactagt actgtgtact gtatagacag 2880
tttgtaaatg ttatttctgc aaacaaacac ctccttatta tatataatat atatatatat 2940
atcagtttga tcacactatt ttagagtctt aatgccaagt cagcagattt gctttatgaa 3000
ttacagggac tagaaatgcc cacattcagg aaatttgtaa taacattgtc tagacaccta 3060
tcctcattct agtagaaagt gtgtacatac tgtaaatatg tgtgattgct tgacttgaaa 3120
aggtttgaat tctgaatgtt ataccatcct tgtaagtaag tttgtaattt ccaccataaa 3180
ttatggtaaa tataaaactc cagaggttgt tctactccat acagttcaca ctgattgtga 3240
cacattctta gtagctagtg tctgttctag tcactgcact ggagtctacg agccggaact 3300
ctatatgc acgtgtgtgt gtccgtatgt aagaaagtgt gcaccgagtg actgaatggt 3360
tgagatgaat tggaatgctg aagactaacg aagaaactag agactgatat cgagcattct 3420
gcccacctcg ctctgtattt aattaattgt gctatatgtt gctttaacaa cccattgagc 3480
agtcagggaa tgtgagtaag cttgctgcca aaggtaacta ggaaagcatt catctgctgc 3540
ctccttgttt ttgctcctag agagtgaaaa tacaggcaat tttactgtga gtgtttcact 3600
ggaaatgtac aatctttgtg tgttagagta tttgttttag taagaaatgt ttacacagct 3660
tgtggaatta tttcgtggga aaataaattt ttataacttc tccc 3704
<210>8
<211>4184
<212>DNA
<213>人
<400>8
ccggggctga gctgcggcgg cgcctgacaa tgccccctcg cgccccggcc tcggcgcccg 60
ctcccggctc cagcgcgcct gcacgtacgt agccttcacg tgtgtgtgga tacggagtgc 120
atgtgtggag acagaggaat atgctccaac aaatttcgga tagaggcgcc gaagacagga 180
cgtggggaag ctaaagaagt aaacaggtca tggcacgttt aacaaaaaga cgacaggcgg 240
atacaaaagc tatccagcat ctttgggcag ccattgagat tatacggaac cagaagcaga 300
ttgccaacat tgaccgtatt acaaagtata tgtctcgagt ccacggtatg caccctaaag 360
agaccacccg tcagctgagc ttagctgtga aagatggtct tattgtcgaa actctaacag 420
tgggctgcaa aggttcaaaa gctggtattg aacaagaagg atattggttg ccaggagatg 480
agattgactg ggaaacagaa aatcatgact ggtattgttt tgaatgccat ttgcctggag 540
aggtgttgat atgtgacctg tgttttcgtg tgtatcattc caagtgtttg tctgatgagt 600
tcaggcttag agacagcagt agtccctggc agtgcccagt ttgcaggagc attaagaaga 660
agaatacaaa caaacaggag atgggcacat acctcagatt cattgtctcc cgcatgaagg 720
agagggctat agatcttaat aaaaagggga aggacaataa acacccgatg tacaggaggc 780
tggtgcactc agctgtggac gttcccacca ttcaagagaa agtgaatgaa gggaaatacc 840
gaagttatga agagttcaaa gctgatgccc aattgcttct ccacaatacc gtgattttct 900
atggagcaga cagtgagcaa gctgacattg cgaggatgct atataaagac acatgtcatg 960
agctggatga actgcagctt tgcaagaatt gcttttactt gtcaaatgct cgtcctgaca 1020
tggttctg ttatccttgt atacctaatc atgagctggt ttgggctaaa atgaaaggtt 1080
ttgggttttg gccagccaaa gtcatgcaga aagaagacaa tcaagtcgac gttcgcttct 1140
ttggccacca ccaccagagg gcctggattc cttctgaaaa cattcaagat atcacagtca 1200
acattcatcg gctgcacgtg aagcgcagta tgggttggaa aaaggcctgt gatgagctgg 1260
agctgcatca gcgtttccta cgagaaggga gattttggaa atctaagaat gaggaccgag 1320
gtgaggaaga ggcagaatcc agtatctcct ccaccagtaa tgagcagcta aaggtcactc 1380
aagaaccaag agcaaagaaa ggacgacgta atcaaagtgt ggagcccaaa aaggaagaac 1440
cagagcctga aacagaagca gtaagttcta gccaggaaat acccacgatg cctcagccca 1500
tcgaaaaagt ctccgtgtca actcagacaa agaagttaag tgcctcttca ccaagaatgc 1560
catcggag cacccagacc acaaacgacg gcgtgtgtca gagcatgtgc catgacaaat 1620
acaccaagat cttcaatgac ttcaaagacc ggatgaagtc ggaccacaag cgggagacag 1680
agcgtgttgt ccgagaagct ctggagaagc tgcgttctga aatggaagaa gaaaagagac 1740
aagctgtaaa taaagctgta gccaacatgc agggtgagat ggacagaaaa tgtaagcaag 1800
taaaggaaaa gtgtaaggaa gaatttgtag aagaaatcaa gaagctggca acacagcaca 1860
agcaactgat ttctcagacc aagaagaagc agtggtgcta caactgtgag gaggaggcca 1920
tgtaccactg ctgctggaac acatcctact gctccatcaa gtgccagcag gagcactggc 1980
acgcggagca caagcgcacc tgccgccgga aaagatgaag ctggcccttc ccggagtcac 2040
cccgatgatt actcttttca gacacagcgg tttttgtttc caagaagcca aaattgttta 2100
gaatttgctt cccattttgc accagccttt aaacactttt cgtgaagaaa ttttgcacag 2160
tagtttaaat cttttgttaa tgctcctccg aagtttttca gggggtaaaa gtaacatcag 2220
tggagggtat tattttaaat aaattttaat tgagaatttg ttgcattttc agcaaatttt 2280
aaaacatttt taggttttac agagatttta acctttaaac aacagatctt taaaaaacag 2340
gtgaatacaa gtgagtttaa caaagaaaca tttagaatag atctgaatgt aagaactaca 2400
gaactgtttc agaaataaaa catactacct tgatgtgaca tttttttctt aaccttgttg 2460
agctggtttt gttcagctta atttactgtt caaaggcatt atctgttggt cacaccagtg 2520
ggtatatgat tgaatttagg gaacagggtt gacacagcag ggctagtcct gcatattttt 2580
tcttaaatat ttcccaattg tgtttttcat tatttctttt caatatataa cttttataac 2640
aaattattag ctttgatctt gtagtttaaa attgcaggga actggggtaa tcttttactg 2700
ctggatct tagagaaaat gaatatttaa attttaaagt ttgcacattt catctttgtc 2760
ctaacatgag tgcttgtaac aaaataaaca acaaaaacaa agccaaaaac tacctttatc 2820
catatgtgaa attatagatg aggcatacga atttgtttaa tgcttccctt cccttcccac 2880
atatcatctc actgcctatt atctggtgtc acctcatgta tcgtaagtta atactaaaag 2940
aagagaaagc acttaagttt cacagaagcc gttatgtttg tagtaatggg tcattgccta 3000
ctaatgaact ccatcactgt acacagaatg aagaataatg catgttaatt ttcttgtatt 3060
aaagatgccg tgatttgtaa aaagtctgta ttttgcggaa tgtctggatt aagaagcatt 3120
accaatagga atggatcgat agttgaataa tgatttttta tacatagata tataaaatac 3180
agccaggaaa acttaaatta cttttctttt aaaatatctc acaatttatg tggtattttt 3240
aaagactgat cttagaccaa gtcaaattcc catttatcat ttagttattt tttgaggtta 3300
gaataatt tgtacatatt tatttagacc tttgatattt attaaagcaa ttactcacaa 3360
tggaagtgaa agaatcagga gaaaagcctt ttaaaaagta ttctccaggt ttgtcagggt 3420
cactctaaag ataaaaatgt aactaagtct tctgtgaaat atcatccatc taatcttgat 3480
gctgttgcag atggtggtga cacaagttaa ttgacaaact actgccaaat ggtgcacaat 3540
attttgtaaa aagtacccag tagccccatt tcatacaatg tacctaaatt atgcagtaac 3600
ttggcatcat cgttccctcc ttgttgctgt gtaattagtc agtgttgcca cagtgtgtgg 3660
cgctgatgga gatgtcagaa ccgagaacac ttaaccttct ttgattgttt ttcaagtttt 3720
aagacttcga tccaccccta tgagagcaag taattgtgga aatatttttg gtgtaaaatc 3780
attccagagt atgtaatatt taactgatag ctgcatgaaa gtgagattcg tgttactttg 3840
gcttttctgt ctctgttgac acggttgcac atttccaagt tactacagcg tgaaaactgt 3900
gtgtttaaaa aaaaacaaaa ttaaaaaaag agattgtggc ctggttttgt aaaagtttta 3960
ggtaaaatta caattgattg ttttaggaat cattattaaa aattttctgc aaatcataaa 4020
gctatatcga ggtgttgagc ttagccacta tgcacattgt aattattcat tgtggctgtc 4080
cagttctatg atgcattctg gcattttgta agctgctctg actagcaata tatagattca 4140
tttaatgtgt taacattggt taataaatgt atttaaaaaa aact 4184
<210>9
<211>6714
<212>DNA
<213>人
<400>9
ccctaggccc gggtcccgga tccccgcgca cccggccagg ctctggcacg ttttggggga 60
ggtgcctgca ggacccaaca tactcaatga gcttccagcg caatgtccga tcgctcgggg 120
ccgactgcca agggaaagga tggaaagaag tattcctcgc tcaacctgtt tgatacgtat 180
aagggcaagt ccttagagat ccagaaaccc gctgttgccc ctcgccatgg cctgcagagt 240
ctcgggaaag ttgccattgc ccggcgtatg ccacctccag ccaaccttcc aagcctgaaa 300
gccgagaaca aaggcaatga ccccaatgtc tcactagtgc caaaagacgg aacaggatgg 360
gcaagcaaac aggagcagtc cgaccccaag agttccgatg cctcaaccgc tcagccgccg 420
gaatcgcagc cactgccggc ttcacagacg cctgcctcca accagccgaa acgaccccca 480
agcccccg agaacactcc tttggttcca agcggggtaa agtcctgggc acaagccagc 540
gtcacccatg gagcacatgg agatggtgga agggcatcaa gcctactgtc acgattctct 600
cgagaggaat ttccgaccct gcaggcggct ggcgaccagg acaaggctgc caaggaaagg 660
gagtctgccg aacagtcgtc tgggcccgga ccaagcctcc gcccccaaaa ttctacaact 720
tggagggacg gaggtgggcg tggccctgat gagctggagg gcccggactc caaacttcat 780
catggtcatg atccccgggg tgggctacag ccttcaggcc caccccagtt ccctccctac 840
cgcggaatga tgccgccttt catgtatccc ccatatctcc cgttccctcc gccctatgga 900
ccccaggggc cttaccgata ccccactcct gatgggccca gccgttttcc ccgtgtggcg 960
ggcccccgag gctcagggcc accaatgcgc ttagtagagc ctgtgggtcg tccctctatt 1020
ctcaaagagg ataatctcaa agagtttgat cagttggatc aggagaatga tgatggttgg 1080
gcaggggccc atgaagaggt tgactacact gaaaagctca agttcagcga tgaggaagat 1140
gggcgagact ctgatgagga gggagctgag ggccacaggg attcccaatc agcttctggt 1200
gaggaacggc cccctgaagc agatggcaaa aagggcaact cccccaacag cgaaccgccc 1260
actcctaaga cggcctgggc agaaacctct cggcctccag agacagagcc gggacctcct 1320
gccccaaagc ctcccctacc ccctggggac tacccagatc gtgggggtcc tccctgcaag 1380
cccccagcac ctgaagatga ggatgaggca tggcggcagc gacgaaagca gtcgtcatct 1440
gagatttccc tggcagtgga gcgggcccgg cgacggcgag aagaagagga gcggcgcatg 1500
caagaagagc gccgggcagc ctgtgctgag aagctcaagc gactcgatga aaagtttggg 1560
gcacctgaca agcggctcaa agcagagcct gctgccccac ctgctgcccc ttctacccca 1620
tccaccac ctgcagtccc taaagaactc cctgcacctc cagctccacc tccagcatca 1680
gccccaacac cagagaaaga acctgaagag ccagcacagg cccctcctgc ccaatctact 1740
cctactccag gtgtggctgc ggctcccact ctggtgagtg gtggtggcag taccagtagc 1800
accagcagtg gcagcttcga agccagccca gtggaaccac aactgccctc aaaagagggt 1860
cctgaaccac cagaagaggt tcctcctcct accacacccc cagttccaaa ggtggaaccc 1920
aagggtgatg ggattggtcc cacccgccag ccccctagtc agggcttggg ctaccccaaa 1980
tatcagaagt cgttgcctcc tcgtttccag cggcagcagc aggagcagct cctgaagcag 2040
cagcagcagc accagtggca gcagcatcaa cagggctctg cccctcctac cccagtgccc 2100
ccatcaccac cacagcctgt gaccctgggg gctgtgccag ctccacaggc tccacccccg 2160
ccccccaagg ccctgtaccc aggtgctctg ggccggcccc cacccatgcc cccaatgaac 2220
tgatcccc gatggatgat gattcctcct tatgtggacc cccggctcct ccagggtcgt 2280
ccccctctag acttctaccc tcctggtgtg catccctctg gcctagttcc ccgagagcgt 2340
tcagacagtg ggggctcaag ctcagagcca tttgaccgtc atgcacctgc tatgttacgg 2400
gaacggggca ctccaccggt ggatccaaag ttggcctggg taggagatgt cttcaccgcc 2460
acacccgctg aaccccgccc acttacctca cctctgcgcc aggctgcgga tgaggatgac 2520
aaggggatga ggagcgagac tcctccagta cctcccccac caccctatct ggccagttat 2580
ccaggctttc ctgagaatgg agcccctggg cccccaatct ctcgctttcc tctggaggaa 2640
ccagggcccc gtccactccc ctggccccca ggcagtgatg aagtggccaa gatacaaact 2700
ccaccaccca agaaggagcc ccctaaggag gagactgcac agctgacggg gccagaagca 2760
ggccgaaagc ctgcccgcgg agtcgggagt ggaggccagg gccccccacc accacgcaga 2820
gagagtcgca cagagacccg ctggggccct cgtccaggga gcagtcgtcg tggaatccct 2880
ccagaggagc caggggcccc accccgccgg gctgggccta taaagaaacc tccaccacct 2940
acaaaagtag aagagctgcc tcccaagccc ctcgaacagg gggatgaaac ccccaaaccc 3000
ccaaagccag acccactcaa gataaccaag gggaagctag ggggccccaa ggagacccca 3060
cccaatggaa atctttcccc tgccccaagg cttcggaggg actattcgta tgaaagagtg 3120
ggtcctacct cttgccgggg tcggggccga ggcgagtatt ttgccagagg gaggggtttt 3180
cgggggacct atgggggacg agggcgggga gcccgaagcc gggaattccg cagttaccga 3240
gagtttcgag gagatgatgg gcgtggaggt gggacagggg gaccaaacca ccctcctgct 3300
ccccgaggcc gcactgccag cgagacacgg agcgagggtt cagagtatga ggaaatcccc 3360
gcggcgcc ggcagcgggg ctcagaaaca ggcagcgaga cccatgagag tgatctggct 3420
ccttcagaca aggaggctcc cacacccaag gagggaacac tcacccaggt ccctctcgct 3480
cccccaccac caggagcccc accttcacca gccccagccc gcttcactgc ccggggtggg 3540
cgagtcttca ctcccagagg ggtgccatct cgccggggcc gaggaggagg gaggccccct 3600
cctcaagttt gcccaggctg gagccctcca gccaagtctc tggctcccaa gaaacctccc 3660
acaggccctt tgccaccaag taaggagcct ttgaaagaga agttgatccc agggcctctg 3720
tcccctgtgg cgcgcggagg cagcaatgga ggtagcaatg tgggcatgga agatggggag 3780
cgaccccgaa ggaggcgaca tgggagggct cagcagcagg ataaaccgcc tcgtttccgg 3840
aggctgaagc aggaacggga gaatgccgca agggggtctg agggcaagcc ctccctaacc 3900
ttccagcct ccgctcctgc acctgaggag gccctcacaa cagtcacagt ggccccagca 3960
cctcgccggg cagctgccaa gtctcctgat ctgtcaaacc agaactcaga ccaagccaat 4020
gaggaatggg agactgcatc agagagcagt gacttcacca gtgagcgccg aggggacaaa 4080
gaggcacccc caccagtact gctgacaccc aaggctgtgg gaactcctgg gggaggtgga 4140
ggtggagccg taccaggtat ttcagccatg tcccgcggag atctgagcca gagagccaag 4200
gatttgagta aacggagctt ctcaagtcag cggccaggca tggaacggca gaatcggcgc 4260
cctggcccag ggggcaaggc tggcagcagt ggcagcagca gtggaggagg cggtgggggt 4320
cctggaggaa ggaccgggcc aggacgaggc gacaagagga gctggccctc tcccaagaac 4380
cgaagtcgtc ctccagagga gcgtcccccg gggcttcccc tgcctccccc acctcccagc 4440
agttctgctg tcttccgcct ggaccaagtt atccacagca accctgctgg catccaacag 4500
gctctggccc agcttagtag ccgtcaaggg agtgtaactg caccaggggg tcatccaagg 4560
cacaagcctg ggcctcccca agcccctcag ggcccctctc ctaggccccc aacccgatac 4620
gagccccaga gggtcaacag cggcctcagt tctgaccccc actttgagga gccggggcca 4680
atggtgagag gggtgggtgg gactcctcgg gactctgccg gggttagtcc ctttccccct 4740
aaacgtcggg agcggcctcc cagaaaacca gagctgctac aggaggaatc tttgccacct 4800
cctcatagct ctggattctt gggctctaag cctgagggcc caggccctca ggcagagtcc 4860
agagatacag gcacagaggc cctgacccct cacatctgga accgtttaca tactgccact 4920
agccgaaaga gttaccggcc cagctccatg gagccttgga tggagcccct gagtcctttt 4980
gaggatgtgg ctggcacaga aatgagtcag tctgacagtg gggtggacct gagtggggat 5040
tcaggtgt catcaggtcc ctgcagccag cgaagttccc ctgatggagg actcaagggg 5100
gcagcagagg gaccccccaa gaggcctgga ggctcctcac ccctgaatgc tgttccttgt 5160
gagggtccac ctggctctga acctcctagg agaccaccac ctgcccccca cgatggggac 5220
agaaaggagc tgccccggga gcagcctctg ccccctggcc ccattggcac agaacgatca 5280
cagcatacag accgaggcac agagcctggc cccattcggc catcccatcg acctggtccc 5340
ccagtccagt ttggcactag tgacaaggac tcagacttac gcctagtggt aggagacagc 5400
ttgaaagcag agaaggagct aacagcatca gtcactgagg ccattcctgt atcacgagac 5460
tgggagctgc ttcccagtgc tgctgcctct gctgagccac aatccaagaa cctggattct 5520
gggcactgtg tcccggagcc cagctcctca ggccagcgcc tgtatcctga ggttttctat 5580
ggcagtgctg ggccttccag ttctcagatc tctgggggag ccatggactc tcaattacat 5640
aaacagtg gaggcttccg ccctgggaca ccctcactgc acccttacag atcacagccc 5700
ctatacctac cccccggccc agcccctccc tcagcactgc tctctggggt agctctcaag 5760
ggccagtttc tggatttctc cacaatgcaa gctacagagc tggggaagtt gccggctgga 5820
ggagttctct accctccacc ttccttcctc tactctccgg ctttctgccc cagtcctttg 5880
cctgacacat cgttgcttca ggtacgccag gatctgccat ccccttcgga tttttattct 5940
actcctctgc agcctggtgg ccaaagtggc tttctccctt caggggctcc tgcccagcag 6000
atgcttctac ccatggtaga ctcacagctg cctgtggtga actttggctc cctgccgcca 6060
gcaccacctc ctgccccacc tcccctttct ctgttacctg tgggccctgc tctgcagccc 6120
cccagcctgg ctgtgcggcc cccacctgct cctgctactc gggtgctgcc ttcacctgcc 6180
aggcccttcc ccgctagctt ggggcgagca gagctgcatc cagtggaact aaagccgttc 6240
caggattatc aaaaactgag cagcaacctt gggggacctg gatcatcacg gactccccca 6300
actggaaggt ccttctctgg cctcaattcc cgtctcaagg ccacgccttc cacctacagt 6360
ggagtcttcc gcacccagcg cgtcgacctt taccagcagg cctccccacc agatgccctg 6420
cgctggatac ctaagccttg ggagcggaca gggctgccac ctcgagaagg gccctcccga 6480
cgggcagagg agcctgggtc ccgaggggac aaggagcctg ggttgccccc accccgctga 6540
gggagttcct cttgccccct acccccgggg cttgtatata gattataaat atataagggg 6600
gaaaggggtg ggcggggagg ggttgtgggg ctggggcctc acttcccctc ctcccccttc 6660
ccctggtccc ctgtccctgg ggctgtttgt taaaaaagag taataaaagg attt 6714
<210>10
<211>2197
<212>DNA
<213>人
<400>10
gccgcgaggg cggggcccgc agttcggttg cgctgcggag cgcagctgtg agggagtcgc 60
tgtgatccgg ggccccggaa cccgagctgg agctgaagcg caggctgcgg ggcgcggagt 120
cgggaggcct gagtgttcct tccagcatgt cggaggggga gtcccagaca gtacttagca 180
gtggctcaga cccaaaggta gaatcctcat cttcagctcc tggcctgaca tcagtgtcac 240
ctcctgtgac ctccacaacc tcagctgctt ccccagagga agaagaagaa agtgaagatg 300
tctgagat tttggaagag tcgccctgtg ggcgctggca gaagaggcga gaagaggtga 360
atcaacggaa tgtaccaggt attgacagtg catacctggc catggataca gaggaaggtg 420
tagaggttgt gtggaatgag gtacagttct ctgaacgcaa gaactacaag ctgcaggagg 480
aaaaggttcg tgctgtgttt gataatctga ttcaattgga gcatcttaac attgttaagt 540
ttcacaaata ttgggctgac attaaagaga acaaggccag ggtcattttt atcacagaat 600
acatgtcatc tgggagtctg aagcaatttc tgaagaagac caaaaagaac cacaagacga 660
tgaatgaaaa ggcatggaag cgttggtgca cacaaatcct ctctgcccta agctacctgc 720
actcctgtga cccccccatc atccatggga acctgacctg tgacaccatc ttcatccagc 780
acaacggact catcaagatt ggctctgtgg ctcctgacac tatcaacaat catgtgaaga 840
ct tgtcgaga agagcagaag aatctacact tctttgcacc agagtatgga gaagtcacta 900
atgtgacaac agcagtggac atctactcct ttggcatgtg tgcactggag atggcagtgc 960
tggagattca gggcaatgga gagtcctcat atgtgccaca ggaagccatc agcagtgcca 1020
tccagcttct agaagaccca ttacagaggg agttcattca aaagtgcctg cagtctgagc 1080
ctgctcgcag accaacagcc agagaacttc tgttccaccc agcattgttt gaagtgccct 1140
cgctcaaact ccttgcggcc cactgcattg tgggacacca acacatgatc ccagagaacg 1200
ctctagagga gatcaccaaa aacatggata ctagtgccgt actggctgaa atccctgcag 1260
gaccaggaag agaaccagtt cagactttgt actctcagtc accagctctg gaattagata 1320
aattccttga agatgtcagg aatgggatct atcctctgac agcctttggg ctgcctcggc 1380
cccagcagcc acagcaggag gaggtgacat cacctgtcgt gcccccctct gtcaagactc 1440
acacctga accagctgag gtggagactc gcaaggtggt gctgatgcag tgcaacattg 1500
agtcggtgga ggagggagtc aaacaccacc tgacacttct gctgaagttg gaggacaaac 1560
tgaaccggca cctgagctgt gacctgatgc caaatgagaa tatccccgag ttggcggctg 1620
agctggtgca gctgggcttc attagtgagg ctgaccagag ccggttgact tctctgctag 1680
aagagacctt gaacaagttc aattttgcca ggaacagtac cctcaactca gccgctgtca 1740
ccgtctcctc ttagagctca ctcgggccag gccctgatct gcgctgtggc tgtccctgga 1800
cgtgctgcag ccctcctgtc ccttcccccc agtcagtatt accctgtgaa gccccttccc 1860
tcctttatta ttcaggaggg ctgggggggc tccctggttc tgagcatcat cctttcccct 1920
cccctctctt cctcccctct gcactttgtt tacttgtttt gcacagacgt gggcctgggc 1980
cttctcagca gccgccttct agttgggggc tagtcgctga tctgccggct cccgcccagc 2040
gtgtggaa aggaggccca cgggcactag gggagccgaa ttctacaatc ccgctggggc 2100
ggccggggcg ggagagaaag gtggtgctgc agtggtggcc ctggggggcc attcgattcg 2160
cctcagttgc tgctgtaata aaagtctact ttttgct 2197
<210>11
<211>6113
<212>DNA
<213>人
<400>11
taatacttaa ttaccttcta ataattggag cagaagatga acccaactaa tcctttcagt 60
gggcagcagc ctagtgcttt ttcggcgtct tctagtaatg taggaacact tccatctaag 120
ccgccatttc gatttggtca accttctctt tttggacaaa acagtacctt atctgggaag 180
agctcgggat tttcacaggt atccagcttt ccagcgtctt ctggagtaag tcattcctct 240
tcagtgcaaa cattagggtt cacccaaacc tcaagtgttg gacccttttc tggacttgag 300
cacacttcca cctttgtggc tacctctggg ccttcaagtt catctgtgct gggaaacaca 360
ggatttagtt ttaaatcacc caccagtgtt ggggctttcc caagcacttc tgcttttgga 420
caagaagctg gagaaatagt gaactctggt tttgggaaaa cagaattcag ctttaaacct 480
ctggaaaatg cagtgttcaa accaatactg ggggctgaat ctgagccaga gaaaacccag 540
agccaaattg cttctgggtt ttttacattt tcccacccaa ttagtagtgc acctggaggc 600
ctggcccctt tctcttttcc tcaagtaaca agtagttcag ctaccacttc aaattttacc 660
ttcaaaac ctgttagtag taataattca ttatctgcct ttacccctgc tttgtcaaac 720
caaaatgtag aggaagagaa gagaggacct aagtcaatat ttggaagttc taataatagc 780
ttcagtagct tccctgtatc atctgcggtt ttgggcgaac ctttccaggc tagcaaagca 840
ggtgtcaggc aggggtgtga agaagctgtt tcccaggtgg aaccacttcc cagcctaatg 900
aaaggactga aaaggaagga ggaccaggat cgctccccaa ggagacatgg ccacgagcca 960
gcagaagatt cggatcctct gtcccggggc gatcatcctc cagacaaacg acctgtccgc 1020
ctgaatcgac cccggggagg tactttattt ggtcggacga tacaggatgt tttcaaaagc 1080
aataaggaag taggtcgtct gggcaacaag gaggccaaaa aggaaactgg ctttgttgag 1140
tctgcagaaa gtgaccacat ggctatccca ggagggaatc agtctgtcct ggcaccttcc 1200
gattccag gtgtgaataa agaggaagaa actgaaagta gagagaagaa agaagattct 1260
ctaagaggaa ctccggcgcg tcagagtaac agaagcgaga gcacagacag tcttgggggc 1320
ttgtctccct ctgaagtcac agccatccag tgcaagaaca tccctgacta cctcaacgac 1380
aggaccattc tggagaacca ttttggcaaa attgctaaag tgcagcgcat ctttaccagg 1440
cgcagcaaaa agcttgcagt ggtacatttc tttgatcatg catctgcagc cctggctaga 1500
aagaagggga aaagtttgca taaagacatg gctatctttt ggcacaggaa gaaaataagc 1560
cccaataaga aacccttttc cctgaaggag aagaaaccag gtgacggtga agtcagcccg 1620
agcacagagg atgcaccctt tcagcactct cctcttggca aggccgcagg gaggactggt 1680
gctagcagcc tcctgaataa aagctctcca gtgaagaagc caagtcttct aaaggcccac 1740
caattcgagg gagactcttt tgactcagcc tccgagggct ccgagggcct cgggccatgt 1800
gtgctctccc tcagtaccct gataggcact gtggctgaga catccaagga gaagtaccgc 1860
ctgcttgacc agagagacag gatcatgcgg caagctcggg tgaagagaac cgatctggac 1920
aaagcgagga cttttgttgg cacctgcctg gatatgtgtc ctgagaagga gaggtacatg 1980
cgggagaccc gtagccagct gagcgtgttc gaagtggtcc cagggactga ccaggtggac 2040
cacgcagcag ctgtgaaaga gtacagtcgg tcctcggcgg atcaggagga gcccctgccc 2100
cacgagctgc ggcccttgcc agtgctcagc aggaccatgg actacctggt gacccagatc 2160
atggaccaga aggagggcag cctgcgggat tggtatgact tcgtgtggaa ccgcacgcgt 2220
ggcatacgga aggatatcac gcagcagcac ctctgtgacc ccctgacggt gtccctgatt 2280
gagaagtgca cccggtttca catccactgt gcccacttca tgtgtgagga gcccatgtcc 2340
ctttgatg ccaagatcaa taatgagaac atgaccaagt gcctgcagag cctgaaggag 2400
atgtaccagg acctgagaaa caagggtgtc ttctgtgcca gcgaagcgga gttccagggc 2460
tacaatgttc tgctcagtct caacaaggga gacatcctaa gagaagtaca acagttccat 2520
cctgctgtta gaaactcatc tgaggtgaaa tttgctgttc aggcttttgc tgcattgaac 2580
agtaataatt ttgtgagatt tttcaaactg gtccagtcag cttcttacct gaacgcttgt 2640
cttttacact gttacttcag tcagatccgc aaggatgctc tccgggcgct caactttgcg 2700
tacacggtga gcacacagcg atctaccatc tttcccctgg atggtgtggt gcgcatgctg 2760
ctgttcagag actgtgaaga ggccaccgac ttcctcacct gccacggcct caccgtttcc 2820
gacggctgtg tggagctgaa ccggtctgca ttcctggaac cagagggatt atccaagacc 2880
aggaagtcgg tgtttattac taggaagctg acggtgtcag tcggggaaat tgtgaacgga 2940
gggccattgc cccccgtccc tcgtcatacc cctgtgtgca gcttcaactc ccagaacaag 3000
tacatcgggg agagcctggc cgcggagctg cccgtcagca cccagagacc cggctccgac 3060
acagtgggcg gagggagagg agaggagtgt ggtgtagagc cggatgcacc cctgtccagt 3120
ctcccacagt ctctaccagc ccctgcgccc tcaccagtgc ctctgcctcc tgtcctggca 3180
ctgaccccgt ctgtggcgcc cagcctcttc cagctgtctg tgcagcctga accaccgcct 3240
ccagagcccg tgcccatgta ctctgacgag gacctggcgc aggtggtgga cgagctcatc 3300
caggaggccc tgcagaggga ctgtgaggaa gttggctctg cgggtgctgc ctacgcagct 3360
gccgccctgg gtgtttctaa tgctgctatg gaggatttgt taacagctgc aaccacgggc 3420
attttgaggc acattgcagc tgaagaagtg tctaaggaaa gagagcgaag ggagcaggag 3480
aggcagcggg ctgaagagga aaggttgaaa caagagagag agctggtgtt aagtgagctg 3540
agccagggcc tggccgtgga gctgatggaa cgcgtgatga tggagtttgt gagggaaacc 3600
tgctcccagg agttgaagaa tgcagtagag acagaccaga gggtccgtgt ggcccgttgc 3660
tgtgaggatg tctgtgccca cttagtggac ttgtttctcg tggaggaaat cttccagact 3720
gcaaaggaga ccctccagga gcttcagtgc ttctgcaagt atctacagcg gtggagggaa 3780
gctgtcacag cccgcaagaa actgaggcgc caaatgcggg ctttccctgc tgcgccctgc 3840
tgcgtggacg tgagcgaccg gctgagggcg ctggcgccca gcgcagagtg ccccattgct 3900
gaagagaacc tggccagggg cctcctggac ctgggccatg cagggagatt gggcatctcc 3960
tgcaccaggt taaggcggct cagaaacaag acagctcacc agatgaaggt tcagcacttc 4020
taccagcagc tgctgagtga tgtggcatgg gcgtctctgg acctgccatc cctcgtggct 4080
gcacctcc ctgggaggca ggagcatgtg ttttggaagc tggtgctggt gttgccggat 4140
gtagaggagc agtccccaga gagttgtggc agaattctag caaattggtt aaaagtcaag 4200
ttcatgggag atgaaggctc agtggatgac acatccagcg atgctggtgg gattcagacg 4260
ctttcgcttt tcaactcact tagcagcaaa ggggatcaga tgatttctgt taacgtgtgt 4320
ataaaggtgg cccatggcgc cctcagtgat ggtgccattg atgctgtgga gacacagaag 4380
gacctcctgg gagccagtgg gctcatgctg ctgcttcccc ccaaaatgaa gagtgaggac 4440
atggcagagg aggacgtgta ctggctgtcg gccttgctgc agctcaagca gctcctgcag 4500
gctaagccct tccagcctgc gcttcctctg gtggttcttg tgcctagccc aggaggggac 4560
gccgttgaga aggaagtaga agatggtctg atgctacagg acttggtttc agctaagctg 4620
ttcagatt acactgttac cgagatccct gataccatta atgatctaca aggttcaact 4680
aaggttttgc aagcagtgca gtggctggtt tcccactgcc cccattccct tgacctctgc 4740
tgccagactc tcattcagta cgtcgaagac gggattggcc atgagtttag tggccgcttt 4800
ttccatgaca gaagagagag gcgtctgggc ggtcttgctt ctcaggagcc tggcgccatc 4860
attgagctgt ttaacagtgt gctgcagttc ctggcttctg tggtgtcctc tgaacagctg 4920
tgtgacctgt cctggcctgt cactgagttt gctgaggcag ggggcagccg gctgcttcct 4980
cacctgcact ggaatgcccc agagcacctg gcctggctga agcaggctgt gctcgggttc 5040
cagcttccgc agatggacct tccacccctg ggggccccct ggctccccgt gtgctccatg 5100
gttgtccagt acgcctccca gatccccagc tcacgccaga cacagcctgt cctccagtcc 5160
caggtggaga acctgctcca cagaacctac tgtaggtgga agagcaagag tccctcccca 5220
gtccatgggg caggcccctc ggtcatggag atcccatggg atgatcttat cgccttgtgt 5280
atcaaccaca agctgagaga ctggacgccc ccccggcttc ctgttacatc agaggcgctg 5340
agtgaagatg gtcagatatg tgtgtatttt tttaaaaacg atttgaaaaa atatgatgtt 5400
cctttgtcgt gggaacaagc caggttgcag acgcagaagg agctacagct gagagaggga 5460
cgtttggcaa taaagccttt tcatccttct gcaaacaatt ttcccatacc attgcttcac 5520
atgcaccgta actggaagag gagcacagag tgtgctcaag aggggaggat tcccagcaca 5580
gaggatctga tgcgaggagc ttctgctgag gagctcttgg cgcagtgttt gtcgagcagt 5640
ctgctgctgg agaaagaaga gaacaagagg tttgaagatc agcttcagca atggttgtct 5700
gaagactcag gagcatttac ggatttaact tcccttcccc tctatcttcc tcagactcta 5760
gtctcttt ctcacactat tgaacctgtg atgaaaacat ctgtaactac tagcccacag 5820
agtgacatga tgagggagca actgcagctg tcagaggcga caggaacgtg tctaggcgaa 5880
cgactaaagc acctggaaag gctgatccgg agttcaaggg aagaggaagt tgcctctgag 5940
ctccatctct ctgcgctgct agacatggtg gacatttgag cagcctgacc tgtggggagg 6000
gggtctctcc cgaagagttt ctgtttttac tcaaaataat gttattctca gatgcttgat 6060
gcactgttgg aaatgtgatt aatttaatca tgcagataaa ccatttaaat gtc 6113
<210>12
<211>6493
<212>DNA
<213>人
<400>12
gaagtccggc cttccgagag ctagctgtcc gccgcggccc ccgcacgccg ggcagccgtc 60
cctcgccgcc tcgggcgcgc caccatgggg ccccggctca gcgtctggct gctgctgctg 120
cccgccgccc ttctgctcca cgaggagcac agccgggccg ctgcgaaggg tggctgtgct 180
ggctctggct gtggcaaatg tgactgccat ggagtgaagg gacaaaaggg tgaaagaggc 240
ctcccggggt tacaaggtgt cattgggttt cctggaatgc aaggacctga ggggccacag 300
ggaccaccag gacaaaaggg tgatactgga gaaccaggac tacctggaac aaaagggaca 360
agaggacctc cgggagcatc tggctaccct ggaaacccag gacttcccgg aattcctggc 420
caagacggcc cgccaggccc cccaggtatt ccaggatgca atggcacaaa gggggagaga 480
gggccgctcg ggcctcctgg cttgcctggt ttcgctggaa atcccggacc accaggctta 540
ccagggatga agggtgatcc aggtgagata cttggccatg tgcccgggat gctgttgaaa 600
ggtgaaagag gatttcccgg aatcccaggg actccaggcc caccaggact gccagggctt 660
caaggtcctg ttgggcctcc aggatttacc ggaccaccag gtcccccagg ccctcccggc 720
cctccaggtg aaaagggaca aatgggctta agttttcaag gaccaaaagg tgacaagggt 780
gaccaagggg tcagtgggcc tccaggagta ccaggacaag ctcaagttca agaaaaagga 840
gacttcgcca ccaagggaga aaagggccaa aaaggtgaac ctggatttca ggggatgcca 900
ggggtcggag agaaaggtga acccggaaaa ccaggaccca gaggcaaacc cggaaaagat 960
ggtgacaaag gggaaaaagg gagtcccggt tttcctggtg aacccgggta cccaggactc 1020
ataggccgcc agggcccgca gggagaaaag ggtgaagcag gtcctcctgg cccacctgga 1080
tgttatag gcacaggacc tttgggagaa aaaggagaga ggggctaccc tggaactccg 1140
gggccaagag gagagccagg cccaaaaggt ttcccaggac taccaggcca acccggacct 1200
ccaggcctcc ctgtacctgg gcaggctggt gcccctggct tccctggtga aagaggagaa 1260
aaaggtgacc gaggatttcc tggtacatct ctgccaggac caagtggaag agatgggctc 1320
ccgggtcctc ctggttcccc tgggccccct gggcagcctg gctacacaaa tggaattgtg 1380
gaatgtcagc ccggacctcc aggtgaccag ggtcctcctg gaattccagg gcagccagga 1440
tttataggcg aaattggaga gaaaggtcaa aaaggagaga gttgcctcat ctgtgatata 1500
gacggatatc gggggcctcc cgggccacag ggacccccgg gagaaatagg tttcccaggg 1560
cagccagggg ccaagggcga cagaggtttg cctggcagag atggtgttgc aggagtgcca 1620
gccctcaag gtacaccagg gctgataggc cagccaggag ccaaggggga gcctggtgag 1680
ttttatttcg acttgcggct caaaggtgac aaaggagacc caggctttcc aggacagccc 1740
ggcatgccag ggagagcggg ttctcctgga agagatggcc atccgggtct tcctggcccc 1800
aagggctcgc cgggttctgt aggattgaaa ggagagcgtg gcccccctgg aggagttgga 1860
ttcccaggca gtcgtggtga caccggcccc cctgggcctc caggatatgg tcctgctggt 1920
cccattggtg acaaaggaca agcaggcttt cctggaggcc ctggatcccc aggcctgcca 1980
ggtccaaagg gtgaaccagg aaaaattgtt cctttaccag gcccccctgg agcagaagga 2040
ctgccggggt ccccaggctt cccaggtccc caaggagacc gaggctttcc cggaacccca 2100
ggaaggccag gcctgccagg agagaagggc gctgtgggcc agccaggcat tggatttcca 2160
gggccccccg gccccaaagg tgttgacggc ttacctggag acatggggcc accggggact 2220
ccaggtcgcc cgggatttaa tggcttacct gggaacccag gtgtgcaggg ccagaaggga 2280
gagcctggag ttggtctacc gggactcaaa ggtttgccag gtcttcccgg cattcctggc 2340
acacccgggg agaaggggag cattggggta ccaggcgttc ctggagaaca tggagcgatc 2400
ggaccccctg ggcttcaggg gatcagaggt gaaccgggac ctcctggatt gccaggctcc 2460
gtggggtctc caggagttcc aggaataggc ccccctggag ctaggggtcc ccctggagga 2520
cagggaccac cggggttgtc aggccctcct ggaataaaag gagagaaggg tttccccgga 2580
ttccctggac tggacatgcc gggccctaaa ggagataaag gggctcaagg actccctggc 2640
ataacgggac agtcggggct ccctggcctt cctggacagc agggggctcc tgggattcct 2700
gggtttccag gttccaaggg agaaatgggc gtcatgggga cccccgggca gccgggctca 2760
aggaccag tgggtgctcc tggattaccg ggtgaaaaag gggaccatgg ctttccgggc 2820
tcctcaggac ccaggggaga ccctggcttg aaaggtgata agggggatgt cggtctccct 2880
ggcaagcctg gctccatgga taaggtggac atgggcagca tgaagggcca gaaaggagac 2940
caaggagaga aaggacaaat tggaccaatt ggtgagaagg gatcccgagg agaccctggg 3000
accccaggag tgcctggaaa ggacgggcag gcaggacagc ctgggcagcc aggacctaaa 3060
ggtgatccag gtataagtgg aaccccaggt gctccaggac ttccgggacc aaaaggatct 3120
gttggtggaa tgggcttgcc aggaacacct ggagagaaag gtgtgcctgg catccctggc 3180
ccacaaggtt cacctggctt acctggagac aaaggtgcaa aaggagagaa agggcaggca 3240
ggcccacctg gcataggcat cccagggctg cgaggtgaaa agggagatca agggatagcg 3300
ggtttcccag gaagccctgg agagaaggga gaaaaaggaa gcattgggat cccaggaatg 3360
cagggtccc caggccttaa agggtctccc gggagtgttg gctatccagg aagtcctggg 3420
ctacctggag aaaaaggtga caaaggcctc ccaggattgg atggcatccc tggtgtcaaa 3480
ggagaagcag gtcttcctgg gactcctggc cccacaggcc cagctggcca gaaaggggag 3540
ccaggcagtg atggaatccc ggggtcagca ggagagaagg gtgaaccagg tctaccagga 3600
agaggattcc cagggtttcc aggggccaaa ggagacaaag gttcaaaggg tgaggtgggt 3660
ttcccaggat tagccgggag cccaggaatt cctggatcca aaggagagca aggattcatg 3720
ggtcctccgg ggccccaggg acagccgggg ttaccgggat ccccaggcca tgccacggag 3780
gggcccaaag gagaccgcgg acctcagggc cagcctggcc tgccaggact tccgggaccc 3840
atggggcctc cagggcttcc tgggattgat ggagttaaag gtgacaaagg aaatccaggc 3900
tggccaggag cacccggtgt cccagggccc aagggagacc ctggattcca gggcatgcct 3960
ggtattggtg gctctccagg aatcacaggc tctaagggtg atatggggcc tccaggagtt 4020
ccaggatttc aaggtccaaa aggtcttcct ggcctccagg gaattaaagg tgatcaaggc 4080
gatcaaggcg tcccgggagc taaaggtctc ccgggtcctc ctggcccccc aggtccttac 4140
gacatcatca aaggggagcc cgggctccct ggtcctgagg gccccccagg gctgaaaggg 4200
cttcagggac tgccaggccc gaaaggccag caaggtgtta caggattggt gggtatacct 4260
ggacctccag gtattcctgg gtttgacggt gcccctggcc agaaaggaga gatgggacct 4320
gccgggccta ctggtccaag aggatttcca ggtccaccag gccccgatgg gttgccagga 4380
tccatggggc ccccaggcac cccatctgtt gatcacggct tccttgtgac caggcatagt 4440
caaacaatag atgacccaca gtgtccttct gggaccaaaa ttctttacca cgggtactct 4500
gctctacg tgcaaggcaa tgaacgggcc catggccagg acttgggcac ggccggcagc 4560
tgcctgcgca agttcagcac aatgcccttc ctgttctgca atattaacaa cgtgtgcaac 4620
tttgcatcac gaaatgacta ctcgtactgg ctgtccaccc ctgagcccat gcccatgtca 4680
atggcaccca tcacggggga aaacataaga ccatttatta gtaggtgtgc tgtgtgtgag 4740
gcgcctgcca tggtgatggc cgtgcacagc cagaccattc agatcccacc gtgccccagc 4800
gggtggtcct cgctgtggat cggctactct tttgtgatgc acaccagcgc tggtgcagaa 4860
ggctctggcc aagccctggc gtcccccggc tcctgcctgg aggagtttag aagtgcgcca 4920
ttcatcgagt gtcacggccg tgggacctgc aattactacg caaacgctta cagcttttgg 4980
ctcgccacca tagagaggag cgagatgttc aagaagccta cgccgtccac cttgaaggca 5040
gggagctgc gcacgcacgt cagccgctgc caagtctgta tgagaagaac ataatgaagc 5100
ctgactcagc taatgtcaca acatggtgct acttcttctt ctttttgtta acagcaacga 5160
accctagaaa tatatcctgt gtacctcact gtccaatatg aaaaccgtaa agtgccttat 5220
aggaatttgc gtaactaaca caccctgctt cattgacctc tacttgctga aggagaaaaa 5280
gacagcgata agctttcaat agtggcatac caaatggcac ttttgatgaa ataaaatatc 5340
aatattttct gcaatccaat gcactgatgt gtgaagtgag aactccatca gaaaaccaaa 5400
gggtgctagg aggtgtgggt gccttccata ctgtttgccc attttcattc ttgtattata 5460
attaattttc tacccccaga gataaatgtt tgtttatatc actgtctagc tgtttcaaaa 5520
tttaggtccc ttggtctgta caaataatag caatgtaaaa atggtttttt gaacctccaa 5580
atggaattac agactcagta gccatatctt ccaacccccc agtataaatt tctgtctttc 5640
tgctatgtgt ggtactttgc agctgctttt gcagaaatca caattttcct gtggaataaa 5700
gatggtccaa aaatagtcaa aaattaaata tatatatata ttagtaattt atatagatgt 5760
cagcaattag gcagatcaag gtttagttta acttccactg ttaaaataaa gcttacatag 5820
ttttcttcct ttgaaagact gtgctgtcct ttaacatagg tttttaaaga ctaggatatt 5880
gaatgtgaaa catccgtttt cattgttcac ttctaaacca aaaattatgt gttgccaaaa 5940
ccaaacccag gttcatgaat atggtgtcta ttatagtgaa acatgtactt tgagcttatt 6000
gtttttattc tgtattaaat attttcaggg ttttaaacac taatcacaaa ctgaatgact 6060
tgacttcaaa agcaacaacc ttaaaggccg tcatttcatt agtattcctc attctgcatc 6120
ctggcttgaa aaacagctct gttgaatcac agtatcagta ttttcacacg taagcacatt 6180
ggccattt ccgtggtttc tcatgagctg tgttcacaga cctcagcagg gcatcgcatg 6240
gaccgcagga gggcagattc ggaccactag gcctgaaatg acatttcact aaaagtctcc 6300
aaaacatttc taagactact aaggcctttt atgtaatttc tttaaatgtg tatttcttaa 6360
gaattcaaat ttgtaataaa actatttgta taaaaattaa gcttttatta atttgttgct 6420
agtattgcca cagacgcatt aaaagaaact tactgcacaa gctgctaata aatttgtaag 6480
ctttgcatac ctt 6493
<210>13
<211>2718
<212>DNA
<213>人
<400>13
gcgaccgctc cccggcggga gccagcgaag gtttccatgt cagaggccga tggagaactg 60
aagattgcca cctacgcaca aaggccattg agacacttcg tgtagctgga agacaccaac 120
ttcctgacag gagctttatt tcatttggga tttcaagttt acagatggta tcttctcaaa 180
agttggaaaa acctatagag atgggcagta gcgaacccct tcccatcgca gatggtgaca 240
ggaggaggaa gaagaagcgg aggggccggg ccactgactc cttgccagga aagtttgaag 300
atatgtacaa gctgacctct gaattgcttg gagagggagc ctatgccaaa gttcaaggtg 360
ccgtgagcct acagaatggc aaagagtatg ccgtcaaaat catcgagaaa caagcagggc 420
acagtcggag tagggtgttt cgagaggtgg agacgctgta tcagtgtcag ggaaacaaga 480
acattttgga gctgattgag ttctttgaag atgacacaag gttttacttg gtctttgaga 540
aattgcaagg aggttccatc ttagcccaca tccagaagca aaagcacttc aatgagcgag 600
aagccagccg agtggtgcgg gacgttgctg ctgcccttga cttcctgcat accaaagaca 660
aagtctctct ctgtcaccta ggctggagtg ctatggcgcc atcagggctc actgcagccc 720
caacctccct gggctccagt gatcctccca cctcagcctc ccaagtagct gggactacag 780
gcattgctca tcgtgatctg aaaccagaaa atatattgtg tgaatctcca gaaaaggtgt 840
ctccagtgaa aatctgtgac tttgacttgg gcagtgggat gaaactgaac aactcctgta 900
cccccataac cacaccagag ctgaccaccc catgtggctc tgcagaatac atggcccctg 960
aggtagtgga ggtcttcacg gaccaggcca cattctacga caagcgctgt gacctgtgga 1020
ctgggcgt ggtcctctac atcatgctga gtggctaccc acccttcgtg ggtcactgcg 1080
gggccgactg tggctgggac cggggcgagg tctgcagggt gtgccagaac aagctgtttg 1140
aaagcatcca ggaaggcaag tatgagtttc ctgacaagga ctgggcacac atctccagtg 1200
aagccaaaga cctcatctcc aagctcctgg tgcgagatgc aaagcagaga cttagcgccg 1260
cccaagttct gcagcaccca tgggtgcagg ggcaagctcc agaaaaggga ctccccacgc 1320
cgcaagtcct ccagaggaac agcagcacaa tggacctgac gctcttcgca gctgaggcca 1380
tcgcccttaa ccgccagcta tctcagcacg aagagaacga actagcagag gagccagagg 1440
cactagctga tggcctctgc tccatgaagc tttcccctcc ctgcaagtca cgcctggccc 1500
ggagacgggc cctggcccag gcaggccgtg gtgaagacag gagcccgccc acagcactct 1560
aatgctcc agtcacacct tataggccct aggcctggcc aggcattgtc ccctggaaac 1620
ctgtgtggct aaagtctgct gagcaggcag cagcctctgc tctgtggctc cattcaggct 1680
ttttcatcta cgaaggccct gaggttccca tcaaccccca tttccctagg gtcctggagg 1740
aaaaagcttt ttccaaaggg gttgtctttg aaaaggaaag caatcacttc tcactttgca 1800
taattgcctg cagcaggaac atctcttcac tgggctccac ctgctcaccc gcctgcagat 1860
ctgggatcca gcctgctctc accgctgtag ctgtggcggc tggggctgca gcctgcaggg 1920
agaagcaaga agcatcagtt gacagaggct gccgacacgt gcctcttccc tctcttctct 1980
gtcaccctcc tctggcggtc cttccacctt cctctgtcct ccggatgtcc tctttgcccg 2040
tcttctccct tggctgagca aagccatccc ctcaattcag ggaagggcaa ggagccttcc 2100
tcattcagga aatcaaatca gtcttccggt ctgcagcacg gaaaagcaca taatctttct 2160
ttgctgtgac tgaaatgtat ccctcgttta tcatcccctt tgtttgtgat tgctgctaaa 2220
gtcagtagta tcgttttttt aaaaaaaaag tttggtgttt ttaaccatgc tgttccagca 2280
aagatgatac cttaaactcc cactgcaagc ccatgaactt cccagagagt ggaacggctt 2340
gctcttcttt ctagaatgtc catgcacttg ggttttaatc agcagttccc tattattctg 2400
attttaagct gttcctgtga tgaacttaga gacagcatcg gtgtctgctg ctgtgtcccc 2460
aggtcttgtg tgggtggcac agatctgggc agttagatag tgctctgtgc ctaaggtgaa 2520
gccacactag ggtgaagcct cacttccctg tttgagcaat gcagtgcctg ctgcccgtgt 2580
gcatgaaggt acagccattc agataagtgg aactattgag ttacataaag aaaatagatt 2640
tgcatttgtc aggcagacgt ttatacaaca ccacggtgct tttatacatt gtgcttattt 2700
ataaaact gaaattct 2718
<210>14
<211>1840
<212>DNA
<213>人
<400>14
gcggcgcgag ccacatgcga gcgggcgcct ggcggcggcg gcggcggcac cagcgatccc 60
agcagcggcc acgacgcgga cgcgcctgcg gcccggggag cagcagcagc cacagccaca 120
gcagccgcca ctgcagttag agcggcagca gcagcgacag ccacagcagc agccgccgcg 180
gagagcggcg ctcggcgggc gcgccctcct gaaggaagcc gcccgccccc caccgccgcc 240
ccctccggcg tgttcatgcc cccggggccc cagggagcgc catggcccgc gcacgccagg 300
agggcagctc cccggagccc gtagagggcc tggcccgcga cggcccgcgc cccttcccgc 360
tcggccgcct ggtgccctcg gcagtgtcct gcggcctctg cgagcccggc ctggctgccg 420
cccccgccgc ccccaccctg ctgcccgctg cctacctctg cgcccccacc gccccacccg 480
ccgtcaccgc cgccctgggg ggttcccgct ggcctggggg tccccgcagc cggccccgag 540
gcccgcgccc ggacggtcct cagccctcgc tctcgctggc ggagcagcac ctggagtcgc 600
ccgtgcccag cgccccgggg gctctggcgg gcggtcccac ccaggcggcc ccgggagtcc 660
gcggggagga ggaacagtgg gcccgggaga tcggggccca gctgcggcgg atggcggacg 720
acctcaacgc acagtacgag cggcggagac aagaggagca gcagcggcac cgcccctcac 780
cctggagggt cctgtacaat ctcatcatgg gactcctgcc cttacccagg ggccacagag 840
cccccgagat ggagcccaat taggtgcctg cacccgcccg gtggacgtca gggactcggg 900
gggcaggccc ctcccacctc ctgacaccct ggccagcgcg ggggactttc tctgcaccat 960
gtagcatact ggactcccag ccctgcctgt cccgggggcg ggccggggca gccactccag 1020
ccccagccca gcctggggtg cactgacgga gatgcggact cctgggtccc tggccaagaa 1080
gccaggagag ggacggctga tggactcagc atcggaaggt ggcggtgacc gagggggtgg 1140
ggactgagcc gcccgcctct gccgcccacc accatctcag gaaaggctgt tgtgctggtg 1200
cccgttccag ctgcaggggt gacactgggg gggggggggc tctcctctcg gtgctccttc 1260
actctgggcc tggcctcagg cccctggtgc ttccccccct cctcctggga gggggcccgt 1320
gaagagcaaa tgagccaaac gtgaccacta gcctcctgga gccagagagt ggggctcgtt 1380
tgccggttgc tccagcccgg cgcccagcca tcttccctga gccagccggc gggtggtggg 1440
catgcctgcc tcaccttcat cagggggtgg ccaggagggg cccagactgt gaatcctgtg 1500
ctctgcccgt gaccgccccc cgccccatca atcccattgc ataggtttag agagagcgac 1560
gtgtgaccac tggcattcat ttggggggtg ggagattttg gctgaagccg ccccagcctt 1620
agtccccagg gccaagcgct ggggggaaga cggggagtca gggagggggg gaaatctcgg 1680
aagagggagg agtctgggag tggggaggga tggcccagcc tgtaagatac tgtatatgcg 1740
ctgctgtaga taccggaatg aattttctgt acatgtttgg ttaatttttt ttgtacatga 1800
tttttgtatg tttccttttc aataaaatca gattggaaca 1840
<210>15
<211>3093
<212>DNA
<213>人
<400>15
tagaatctgt tcaggaagtt ggaggttctt actggcaaag agtaactctc atcctggaat 60
tactgcagca caaaaagaag ctcagaagtc ctcagatatt ggtgccaact ctttttaact 120
tgctatcaag atgtttagaa cccttgccac aagagcaggg aaatatggaa tacaccaaac 180
aattaattct tagttgtctg ctcaacatct gccaaaaact atctccagat ggtggcaaaa 240
tacccaaaga tattttagat gaggagaagt tcaacgtgga gttgatagtt cagtgcatcc 300
gcctttcgga gatgccgcag acccatcacc atgccctttt acttttgggc actgttgctg 360
gaatatttcc ggataaagtt ttacacaata tcatgtctat ttttacattt atgggagcca 420
atgtcatgcg cctagatgat acttacagtt ttcaagttat taacaagaca gtgaaaatgg 480
ttattcccgc acttattcag tctgatagtg gagattctat agaagtttca agaaacgttg 540
aagagattgt ggtaaaaatc attagtgtat ttgtggatgc gctgccacac gtcccggagc 600
acaggcgcct gcccatcctt gttcaacttg ttgatacact gggtgcagag aaattcctct 660
ggattctcct catcttgctt tttgaacagt atgtcacaaa aacagtgctg gcggctgcct 720
atggcgaaaa ggatgctatt ttagaagcag acactgaatt ttggttttca gtctgttgtg 780
tttagtgt ccagcatcag atacaaagct tgatgaatat cctccagtac ttactaaagc 840
tgccagagga aaaagaagaa accattccca aagcagtgtc atttaataag agtgaatcac 900
aagaagaaat gctacaggtt tttaatgtag agactcacac tagcaagcaa ctgcggcatt 960
ttaaattttt gtcagtgtcc ttcatgtctc agctcctgtc ttccaatgat tttctgaaaa 1020
aggtagttga gagtggtggt cctgagattt taaaaggcct tgaagagagg ttgctggaga 1080
ccgttctcgg ctatatcagt gcagttgcac agtccatgga aaggaacgca gacaaactca 1140
ccgtgaagtt ctggcgcgcg ctccttagta aagcttacga cctgttagat aaggtcaatg 1200
ccttgctgcc cacagagaca ttcattcctg tgatcagagg gctggtgggc aatcccctgc 1260
catctgttcg ccgcaaagcg ctggaccttt tgaataacaa gctgcagcaa aatatatcct 1320
ggaagaagac aatagttacc cgtttcctaa aactggttcc agaccttttg gccattgtgc 1380
agcgtaagaa aaaggaaggg gaagaagaac aagcaatcaa cagacagaca gcgttgtata 1440
ccttaaagct tttatgcaag aattttggtg cagaaaatcc agatcctttt gtcccagtgc 1500
tgagcactgc tgtgaaactg attgctccag agagaaagga ggagaagaat gtcttgggaa 1560
gcgcgctgct gtgcatagca gaggtgacct ccaccctgga ggcgctggcc atcccccagc 1620
ttcccagcct gatgccatcg ttgctgacaa caatgaagaa caccagcgag ctggtctcca 1680
gcgaggtcta cctgctcagt gccttggctg ctctgcagaa ggttgtggag actctcccgc 1740
acttcatcag cccctatctg gaaggcattc tctcccaggt gattcatctg gagaaaatca 1800
ctagtgaaat gggttctgcg tcacgggcta atatccgtct cacatctctt aaaaagacac 1860
tggctaccac acttgcaccc cgagtcctgt tgcccgccat caaaaaaact tacaagcaga 1920
ttgagaagaa ctggaagaat cacatgggtc cgtttatgag catcttgcaa gagcatattg 1980
gggcgatgaa gaaggaagag ctcacctccc atcagtctca gctaaccgcc tttttcctgg 2040
aggccctgga cttccgagcc cagcactctg agaacgatct ggaggaagtt ggaaaaacgg 2100
aaaattgtat cattgactgt ctagtagcca tggttgtcaa actttccgag gtcacattca 2160
ggcccctgtt cttcaagctg tttgattggg ctaaaacaga agatgcccca aaggacaggt 2220
tgttgacatt ttacaacttg gcagattgca ttgctgaaaa gctgaaaggg ctttttactc 2280
tgtttgccgg ccacttagtg aagccttttg ctgacacctt ggaccaggtg aacatctcca 2340
aaacagatga agcatttttt gactctgaaa atgaccctga aaagtgctgc ttgctgttgc 2400
agtttatttt gaactgttta tacaaaatct tcctttttga tacccagcat tttataagta 2460
aagagagagc aggagccttg atgatgcctc tggtggatca gctggtaaac aggcttgggg 2520
gagaagagaa attccaggaa cgggtgacaa agcacctgat accatgcatc gcacagtttt 2580
cagtggccat ggcggatgac tctctttgga aaccactgaa ctaccagatt ctgctaaaga 2640
cgagagactc ctcgcctaag gttcgatttg ctgctttgat tactgtgtta gcactggctg 2700
aaaaactaaa ggagaattat attgtcttgc taccagaatc cattcctttc ttagcagagt 2760
tgatggaaga tgaatgtgaa gaagtagaac atcagtgcca aaagactatt cagcaactgg 2820
aaactgtcct gggagagcca ctccagagct atttctaaga ctttctgtgg tgtttcatac 2880
tctactcaga gttcacactc atatttcata tttttatttt tgggtgttgg gtgccatgtt 2940
acttttggtg ccttaataca cctacttgga ttacttacaa atgttttatc acttcgttac 3000
aaaatcccca cctggcttgt gctgccacat aagcctctcc tgcctatcgt atagagctgc 3060
gaaagagta aatgatacac ggtattttta tac 3093
<210>16
<211>1702
<212>DNA
<213>人
<400>16
caaaatccca ggcagcatgg acctcagtct tctctgggta cttctgcccc tagtcaccat 60
ggcctggggc cagtatggcg attatggata cccataccag cagtatcatg actacagcga 120
tgatgggtgg gtgaatttga accggcaagg cttcagctac cagtgtcccc aggggcaggt 180
gatagtggcc gtgaggagca tcttcagcaa gaaggaaggt tctgacagac aatggaacta 240
cgcctgcatg cccacgccac agagcctcgg ggaacccacg gagtgctggt gggaggagat 300
caacagggct ggcatggaat ggtaccagac gtgctccaac aatgggctgg tggcaggatt 360
ccagagccgc tacttcgagt cagtgctgga tcgggagtgg cagttttact gttgtcgcta 420
cagcaagagg tgcccatatt cctgctggct aacaacagaa tatccaggtc actatggtga 480
ggaaatggac atgatttcct acaattatga ttactatatc cgaggagcaa caaccacttt 540
ctctgcagtg gaaagggatc gccagtggaa gttcataatg tgccggatga ctgaatacga 600
ctgtgaattt gcaaatgttt agatttgcca cataccaaat ctgggtgaaa ggaaaggggc 660
cggggacagg agggtgtcca catatgttaa catcagttgg atctcctata gaagtttctg 720
gctctctt tccttctccc tgagctggta actgcaatgc caacttcctg ggcctttctg 780
actagtatca cacttctaat aaaatccaca attaaaccat gtttctcact tttcacatgt 840
ttcatagcaa ctgctttata tgactgatga tggcttcctt gcacaccaca tatacagtgc 900
gcatgcttac agccgggctt ctggagcacc agctgcagcc tggctactgc tttttactgc 960
agaatgaact gcaagttcag catagtggag gggagaggca gaactggagg agaggtgcag 1020
tgaaggttct ctacagctaa gcctgtttga atgatacgta ggttccccac caaaagcagg 1080
ctttctgccc tgagggacat cttcccactc ccctgctcca catgagccat gcatgcttag 1140
caatccaagt gcagagctct ttgctccagg agtgaggaga ctgggaggtg aaatggggaa 1200
atggaagggt ttggaggcag agctgaaaac agggttggaa ggatttcctg aattagaaga 1260
caaacgttag catacccagt aaggaaaatg agtgcagggg ccaggggaac ccgtgaggat 1320
actctcaaa tgagattaaa aacaaggaag cagagaatgg tcagagaatg ggattcagat 1380
tgggaacttg tggggatgag agtgaccagg ttgaactggg aagtggaaaa aggagtttga 1440
gtcactggca cctagaagcc tgcccacgat tcctaggaag gctggcagac accctggaac 1500
cctggggagc tactggcaaa ctctcctgga ttgggcctga tttttttggt gggaaaggct 1560
gccctgggga tcaactttcc ttctgtgtgt ggctcaggag ttcttctgca gagatggcgc 1620
tatctttcct cctcctgtga tgtcctgctc ccaaccattt gtactcttca ttacaaaaga 1680
aataaaaata ttaacgttca ct 1702
<210>17
<211>2730
<212>DNA
<213>人
<400>17
agaatgccta tgagacacag gaagaaggca gcagacaaga atcttccctg ccgtccttta 60
gtatgtgcag tactggacct gatggtagag tttattgtaa cacacatgat gaaggagttt 120
cctatggatc tctatatacg ctgcatccag gtagtacaca aactgctctg ctaccagaag 180
aagtgtcggg tacgcctgca ttacacctgg cgggagctct ggtcagcctt gataaatttg 240
ctgaagttcc ttatgtcaaa tgagactgta cttttggcca aacacaacat ttttacatta 300
gcccttatga ttgtgaacct atttaatatg tttatcacat atggcgacac atttctgcca 360
ccccagca gctatgatga actttactat gagattatcc gcatgcacca gagctttgac 420
aacctctact ccatggtcct gaggctttct accaatgcag gccagtggaa ggaagcagct 480
agcaaggtga cccatgcatt ggttaatatc agagccatca tcaaccactt taaccccaaa 540
attgagtcct acgctgctgt gaatcacata tcccaactgt cagaggagca ggtgctggag 600
gtggtgagag ccaactatga cacgctcacg ctgaagctgc aggatggcct ggaccagtat 660
gagcgctact cagagcagca caaggaagct gccttcttca aagagctggt tcgatccatt 720
agcaccaacg tccggagaaa cctggtcttc cacacactca gccaagaagt cctgctcaag 780
gagttctcca ctatctcctg aggccacgcc tacctgagca gcctctgact gcccttaccc 840
atgaggatca tgggctggag ggggagcgag gggagagggg gctgcccccg aggttggaga 900
aaacacaga taccaagttc tcttggtgaa gaccgcactt caatggagct tgggcagcag 960
gggcaggagg gtcaagccag ggataatctt atttggggag gaatgggtgg gcacagtggg 1020
gagaggcctc caggaatgtg gggacttcca gagtgggctc cctaaacagc ccctcacatt 1080
tccaatcttg aggttacaag ctgtagctac tgactaattt tcgggagctg gtgaggcaag 1140
cctcagggta atgccagcac cctgaaagtc agtggctctg ctcggcttct gaaaacagat 1200
caactctcag atatagctgg agctacatcc tgcttccttt gggcctgggg ctgtgcttgg 1260
cttgaaatct gtgtcccctg cctgcactgg cactttgtcc agtcatcggg acctttggct 1320
cagatttagg gtaagatagg aatagggtac ctttttcctt ttttttctga gacggagtct 1380
cactctgtcg cccaggctgg aatgcagtgg cgtgatctcg gctttactgc agcctccgct 1440
tcctgggttc aagcgattct cctgcctcag cctcccgagt agctgggact acaggagcgt 1500
gtgccacgcc cggctaattt tttgtatttt tagtagagat ggagtttcac catgttaccc 1560
aggatggtct caatatcctg agttcatgat ccacccacct tggcctccca aagtgctggg 1620
attacaggcg tgagccacca cacccagcca gttttcctat tttctgaatt cagaattgac 1680
ttctctggga aaactggaga tgagaatctg cccagtgctc tgctgtccag tcaccgcctt 1740
ttgaatttta gttttggcac caggagtacc gttagctttc cccttcttct ggcccatttg 1800
actcatcagc acaatagggt caccacctta acttttaatt tctaatctgc tttactgtct 1860
ttagggtgtg tatgaaataa acattgacag gctttctgga gccctcaagg tgcctacttt 1920
gctggttccc tttccagcag ctcccccacc tcccttagcc ccccctcctc tggcagcctc 1980
tcctgcctct gctgagctcc cctccacgtg ttccaccccc ttaccctgct gttgtttaca 2040
caacctgc ctgagaattt cctctgggga ggaatctatt cctgtcatgg tctagtgcct 2100
gggagggaga gaacttcctg ggggtagggt gccctccatc tgaaacaggc caggtgagca 2160
tcatgcataa ggcctccatt ctgtccgctc agattctggg tggggccaca ggcaaatctc 2220
ctgacttatg gggagttggc ttgtggttcc tcccttggat agcctccatg gaaccactat 2280
aggctttccc aacagctgcc tctgaaatag ctgctgcttc gagatcctcc ctttttaaag 2340
cactttctaa agccctcagg atggcgggag caaacagcac tggtatattc taggagtaag 2400
tgcaggaatt cagcagtgag agcatgtctg ggaccacctg gactgccatc catttaacct 2460
caaatctctt tgggatactc gccctccctg ggaaccagag ttctggctct aacattgagc 2520
agctatgcac tagttccaga gaagccacta acaggctgcc atgtgtagat gtaggttctt 2580
aagagatcac aggctgggtc atctgatcac tggatggata gctcagcctg gggcatttag 2640
ttttccct ggtgataaat ccccaaggca gctggatttg gagctggtgg caagttgaaa 2700
ttattaaaaa ttgatttgtg tgggactgtc 2730
<210>18
<211>1972
<212>DNA
<213>人
<400>18
aggggttggc cctggagtct gccagccaca ctgggaaaac attggagctt ggtctgccat 60
cctgaactgt ggttcccctg cctcccagcc cggctgtgag tgctcagcga ccctgacagg 120
ctgacagttg ggccatatgg tgctcttccc agtctggttc ctgtacagtc tgctcatgaa 180
gctgttccag cgctccacgc cagccatcac cctcgagagc ccggacatca agtacccgct 240
gcggctcatc gaccgggaga tcatcagcca tgacacccgg cgcttccgct ttgccctgcc 300
gtcaccccag cacatcctgg gcctccctgt cggccagcac atctacctct cggctcgaat 360
tgatggaaac ctggtcgtcc ggccctatac acccatctcc agcgatgatg acaagggctt 420
cgtggacctg gtcatcaagg tttacttcaa ggacacccat cccaagtttc ccgctggagg 480
gaagatgtct cagtacctgg agagcatgca gattggagac accattgagt tccggggccc 540
cagtgggctg ctggtctacc agggcaaagg gaagttcgcc atccgacctg acaaaaagtc 600
caaccctatc atcaggacag tgaagtctgt gggcatgatc gcgggaggga caggcatcac 660
cgatgctg caggtgatcc gcgccatcat gaaggaccct gatgaccaca ctgtgtgcca 720
cctgctcttt gccaaccaga ccgagaagga catcctgctg cgacctgagc tggaggaact 780
caggaacaaa cattctgcac gcttcaagct ctggtacacg ctggacagag cccctgaagc 840
ctgggactac ggccagggct tcgtgaatga ggagatgatc cgggaccacc ttccaccccc 900
agaggaggag ccgctggtgc tgatgtgtgg ccccccaccc atgatccagt acgcctgcct 960
tcccaacctg gaccacgtgg gccaccccac ggagcgctgc ttcgtcttct gagggccggg 1020
cacggtcaca cggccacccg ccccgcgcac cccacgccct gttcacgctc acccagtcac 1080
ctccccacat cgcacactgg ggccccgggt tcagcctggc ctgcccgtgc cctggtgaat 1140
cacctggctg agcagttccc ctggagcccc ttcgggagca gggctgtgtc ccagatgggc 1200
acggctgag ccttcagagt acgtcctgcc tggcacttac tggtccttac cagagacgcc 1260
cagccccatc cctgtcctca tgacccctcg tccacccccc acacacacta taaggctgag 1320
ggctgccagc agccccgtct gcccaccatt cccggccgtg gaccatagtc gggatgtcag 1380
cagacacaca tgggcagccc aaagctgcag gtgccagggc ccaccccagc ctcgcctgtc 1440
acccccactc ccgcctcagg gccaggccca ggcctcacca cctgacgctg catgagacat 1500
tgacaccaga aagccctctt gggggcactg ctccctaccc cagggccctg gccagccggg 1560
agcttggctc tcctctggct agagtgggaa gagggggctg gccatggggc cctcccagaa 1620
cctcagcatt tccttccagc ccatccaaac actgaggcag ccttggggaa ccccgagctg 1680
gggggttggc agcccactgc accgcctcag ggttttgggg tcctgggctg gggccaccat 1740
ccctgatggc agaactccca caaccacatg tatttattcc tctgtcctaa accgtcccct 1800
ccttccctca cccccagcac agggggattc tgagcagtgc ctcttgtctg agggacatat 1860
cagtgacctc gacgttgcct ttagactaca gttgtgttag cctcttgcgt attggctttt 1920
tcagagtcat ttatgagcag aaaaaaaaaa agtaaaactt tgctaatatt aa 1972
<210>19
<211>1852
<212>DNA
<213>人
<400>19
cgcgcgac tttttgaaag ccaggagggt tcgaattgca acggcagctg ccgggcgtat 60
gtgttggtgc tagaggcagc tgcagggtct cgctgggggc cgctcgggac caattttgaa 120
gaggtacttg gccacgactt attttcacct ccgacctttc cttccaggcg gtgagactct 180
ggactgagag tggctttcac aatggaaggg atcagtaatt tcaagacacc aagcaaatta 240
tcagaaaaaa agaaatctgt attatgttca actccaacta taaatatccc ggcctctccg 300
tttatgcaga agcttggctt tggtactggg gtaaatgtgt acctaatgaa aagatctcca 360
agaggtttgt ctcattctcc ttgggctgta aaaaagatta atcctatatg taatgatcat 420
tatcgaagtg tgtatcaaaa gagactaatg gatgaagcta agattttgaa aagccttcat 480
catccaaaca ttgttggtta tcgtgctttt actgaagcca atgatggcag tctgtgtctt 540
gctatggaat atggaggtga aaagtctcta aatgacttaa tagaagaacg atataaagcc 600
gccaagatc cttttccagc agccataatt ttaaaagttg ctttgaatat ggcaagaggg 660
ttaaagtatc tgcaccaaga aaagaaactg cttcatggag acataaagtc ttcaaatgtt 720
gtaattaaag gcgattttga aacaattaaa atctgtgatg taggagtctc tctaccactg 780
gatgaaaata tgactgtgac tgaccctgag gcttgttaca ttggcacaga gccatggaaa 840
cccaaagaag ctgtggagga gaatggtgtt attactgaca aggcagacat atttgccttt 900
ggccttactt tgtgggaaat gatgacttta tcgattccac acattaatct ttcaaatgat 960
gatgatgatg aagataaaac ttttgatgaa agtgattttg atgatgaagc atactatgca 1020
gcgttgggaa ctaggccacc tattaatatg gaagaactgg atgaatcata ccagaaagta 1080
attgaactct tctctgtatg cactaatgaa gaccctaaag atcgtccttc tgctgcacac 1140
attgttgaag ctctggaaac agatgtctag tgatcatctc agctgaagtg tggcttgcgt 1200
aaataactgt ttattccaaa atatttacat agttactatc agtagttatt agactctaaa 1260
attggcatat ttgaggacca tagtttcttg ttaacatatg gataactatt tctaatatga 1320
aatatgctta tattggctat aagcacttgg aattgtactg ggttttctgt aaagttttag 1380
aaactagcta cataagtact ttgatactgc tcatgctgac ttaaaacact agcagtaaaa 1440
cgctgtaaac tgtaacatta aattgaatga ccattacttt tattaatgat ctttcttaaa 1500
tattctatat tttaatggat ctactgacat tagcactttg tacagtacaa aataaagtct 1560
acatttgttt aaaacactga accttttgct gatgtgttta tcaaatgata actggaagct 1620
gaggagaata tgcctcaaaa agagtagctc cttggatact tcagactctg gttacagatt 1680
gtcttgatct cttggatctc ctcagatctt tggtttttgc tttaatttat taaatgtatt 1740
ccatactg agtttaaaat ttattaattt gtaccttaag catttcccag ctgtgtaaaa 1800
acaataaaac tcaaatagga tgataaagaa taaaggacac tttgggtacc ag 1852
<210>20
<211>2883
<212>DNA
<213>人
<400>20
ccgggtgggc tccaggcggc cggtccccgg cctcccccca tggccaccgc cccctcttat 60
ccgccgggc tccctggctc tcccgggccg gggtctcctc cgccccccgg cggcctagag 120
ctgcagtcgc cgccaccgct actgccccag atcccggccc cgggttccgg ggtctccttt 180
cacatccaga tcgggctgac ccgcgagttc gtgctgttgc ccgccgcctc cgagctggct 240
catgtgaagc agctggcctg ttccatcgtg gaccagaagt tccctgagtg tggcttctac 300
ggcctttacg acaagatcct gcttttcaaa catgacccca cgtcggccaa cctcctgcag 360
ctggtgcgct cgtccggaga catccaggag ggcgacctgg tggaggtggt gctgtcggcc 420
tcggccacct tcgaggactt ccagatccgc ccgcacgccc tcacggtgca ctcctatcgg 480
gcgcctgcct tctgtgatca ctgcggggag atgctcttcg gcctagtgcg ccagggcctc 540
aagtgcgatg gctgcgggct gaactaccac aagcgctgtg ccttcagcat ccccaacaac 600
tgtagtgggg cccgcaaacg gcgcctgtca tccacgtctc tggccagtgg ccactcggtg 660
cgcctcggca cctccgagtc cctgccctgc acggctgaag agctgagccg tagcaccacc 720
gaactcctgc ctcgccgtcc cccgtcatcc tcttcctcct cttctgcctc atcgtatacg 780
ggccgcccca ttgagctgga caagatgctg ctctccaagg tcaaggtgcc gcacaccttc 840
ctcatccaca gctatacacg gcccaccgtt tgccaggctt gcaagaaact cctcaagggc 900
ctcttccggc agggcctgca atgcaaagac tgcaagttta actgtcacaa acgctgcgcc 960
acccgcgtcc ctaatgactg cctgggggag gcccttatca atggagatgt gccgatggag 1020
gaggccaccg atttcagcga ggctgacaag agcgccctca tggatgagtc agaggactcc 1080
ggtgtcatcc ctggctccca ctcagagaat gcgctccacg ccagtgagga ggaggaaggc 1140
gagggaggca aggcccagag ctccctgggg tacatccccc taatgagggt ggtgcaatcg 1200
gcgacaca cgacgcggaa atccagcacc acgctgcggg agggttgggt ggttcattac 1260
agcaacaagg acacgctgag aaagcggcac tattggcgcc tggactgcaa gtgtatcacg 1320
ctcttccaga acaacacgac caacagatac tataaggaaa ttccgctgtc agaaatcctc 1380
acggtggagt ccgcccagaa cttcagcctt gtgccgccgg gcaccaaccc acactgcttt 1440
gagatcgtca ctgccaatgc cacctacttc gtgggcgaga tgcctggcgg gactccgggt 1500
gggccaagtg ggcagggggc tgaggccgcc cggggctggg agacagccat ccgccaggcc 1560
ctgatgcccg tcatccttca ggacgcaccc agcgccccag gccacgcgcc ccacagacaa 1620
gcttctctga gcatctctgt gtccaacagt cagatccaag agaatgtgga cattgccact 1680
gtctaccaga tcttccctga cgaagtgctg ggctcagggc agtttggagt ggtctatgga 1740
ggaaaacacc ggaagacagg ccgggacgtg gcagttaagg tcattgacaa actgcgcttc 1800
cctaccaagc aggagagcca gctccggaat gaagtggcca ttctgcagag cctgcggcat 1860
cccgggatcg tgaacctgga gtgcatgttc gagacgcctg agaaagtgtt tgtggtgatg 1920
gagaagctgc atggggacat gttggagatg atcctgtcca gtgagaaggg ccggctgcct 1980
gagcgcctca ccaagttcct catcacccag atcctggtgg ctttgagaca ccttcacttc 2040
aagaacattg tccactgtga cttgaaacca gaaaacgtgt tgctggcatc agcagaccca 2100
tttcctcagg tgaagctgtg tgactttggc tttgctcgca tcatcggcga gaagtcgttc 2160
cgccgctcag tggtgggcac gccggcctac ctggcacccg aggtgctgct caaccagggc 2220
tacaaccgct cgctggacat gtggtcagtg ggcgtgatca tgtacgtcag cctcagcggc 2280
accttccctt tcaacgagga tgaggacatc aatgaccaga tccagaacgc cgccttcatg 2340
tacccggcca gcccctggag ccacatctca gctggagcca ttgacctcat caacaacctg 2400
ctgcaggtga agatgcgcaa acgctacagc gtggacaaat ctctcagcca cccctggtta 2460
caggagtacc agacgtggct ggacctccga gagctggagg ggaagatggg agagcgatac 2520
atcacgcatg agagtgacga cgcgcgctgg gagcagtttg cagcagagca tccgctgcct 2580
gggtctgggc tgcccacgga cagggatctc ggtggggcct gtccaccaca ggaccacgac 2640
atgcaggggc tggcggagcg catcagtgtt ctctgaggtc ctgtgccctc gtccagctgc 2700
tgccctccac agcggttctt cacaggatcc cagcaatgaa ctgttctagg gaaagtggct 2760
tcctgcccaa actggatggg acacgtgggg agtggggtgg ggggagctat ttccaaggcc 2820
cctccctgtt tccccagcaa ttaaaacgga ctcatctctg gccccatggc cttgatctca 2880
gca 2883
<210>21
<211>1463
<212>DNA
<213>人
<400>21
cgcccctgac accattcctc ccttcccccc tccaccggcc gcgggcataa aaggcgccag 60
gtgagggcct cgccgctcct cccgcgaatc gcagcttctg agaccagggt tgctccgtcc 120
gtgctccgcc tcgccatgac ttcctacagc tatcgccagt cgtcggccac gtcgtccttc 180
ggaggcctgg gcggcggctc cgtgcgtttt gggccggggg tcgcctttcg cgcgcccagc 240
attcacgggg gctccggcgg ccgcggcgta tccgtgtcct ccgcccgctt tgtgtcctcg 300
tcctcctcgg gggcctacgg cggcggctac ggcggcgtcc tgaccgcgtc cgacgggctg 360
ctggcgggca acgagaagct aaccatgcag aacctcaacg accgcctggc ctcctacctg 420
gacaaggtgc gcgccctgga ggcggccaac ggcgagctag aggtgaagat ccgcgactgg 480
taccagaagc aggggcctgg gccctcccgc gactacagcc actactacac gaccatccag 540
gacctgcggg acaagattct tggtgccacc attgagaact ccaggattgt cctgcagatc 600
gacaatgccc gtctggctgc agatgacttc cgaaccaagt ttgagacgga acaggctctg 660
cgcatgagcg tggaggccga catcaacggc ctgcgcaggg tgctggatga gctgaccctg 720
gccaggaccg acctggagat gcagatcgaa ggcctgaagg aagagctggc ctacctgaag 780
aagaaccatg aggaggaaat cagtacgctg aggggccaag tgggaggcca ggtcagtgtg 840
gaggtggatt ccgctccggg caccgatctc gccaagatcc tgagtgacat gcgaagccaa 900
tatgaggtca tggccgagca gaaccggaag gatgctgaag cctggttcac cagccggact 960
gaagaattga accgggaggt cgctggccac acggagcagc tccagatgag caggtccgag 1020
gttactgacc tgcggcgcac ccttcagggt cttgagattg agctgcagtc acagctgagc 1080
atgaaagctg ccttggaaga cacactggca gaaacggagg cgcgctttgg agcccagctg 1140
gcgcatatcc aggcgctgat cagcggtatt gaagcccagc tgggcgatgt gcgagctgat 1200
agtgagcggc agaatcagga gtaccagcgg ctcatggaca tcaagtcgcg gctggagcag 1260
gagattgcca cctaccgcag cctgctcgag ggacaggaag atcactacaa caatttgtct 1320
ctccaagg tcctctgagg cagcaggctc tggggcttct gctgtccttt ggagggtgtc 1380
ttctgggtag agggatggga aggaagggac ccttaccccc ggctcttctc ctgacctgcc 1440
aataaaaatt tatggtccaa ggg 1463
<210>22
<211>2309
<212>DNA
<213>人
<400>22
cgcgctggag aggcgcgggg tcaagacgtc cggcctcggg ggcccgggct gggccgccga 60
gtcccctggg cggcgctgag cgggcgggag gcgggggccc gcggctcggg gcaaccgagg 120
ccgggtcgcg ggatcggccg ccatcgccgc cgccgctgca ctgggagccc gcggggatgg 180
agcgggaggc gttgccgtgg ggcctcgagc cccaggatgt gcagagttct gacgaaatga 240
ggagccccga agggtacctc agaggcaaca tgagtgagaa tgaggaagag gaaatttctc 300
agcaagaagg cagtggggac tatgaagtcg aagagatacc atttgggctt gaaccccaga 360
gccctgggtt tgagccacaa agcccagagt ttgaacccca aagccccaga tttgagcctg 420
aaagcccggg gtttgagtcc cgaagccctg ggcttgtgcc cccaagccct gagtttgcac 480
ccagaagccc tgaatcagat tctcagagcc ctgagtttga atcccagagc cctaggtatg 540
aaccccaaag ccctggctat gaacctcgga gccccgggta tgaaccccgg agccctggct 600
atgaatctga gagctctaga tatgaatccc agaacactga gctcaaaacc caaagcccag 660
aatttgaagc tcaaagttcc aaattccagg aaggtgcgga gatgcttctg aaccccgacg 720
aaaagagtcc tttgaatatc tccgtaggag ttcaccccct ggactccttc actcaggggt 780
ttggggagca gcccacaggg gacctgccca tagggccacc ttttgagatg cccacagggg 840
ccctgctgtc tacaccgcag tttgagatgc ttcagaatcc cctgggtctc acaggagccc 900
ttcgaggtcc aggtcggcgg ggtggccggg ccaggggtgg gcagggccct cggcctaaca 960
tctgcggcat ctgcgggaag agcttcgggc ggggctccac cctgatccag caccagcgca 1020
tccacaccgg tgagaagccc tacaaatgtg aggtctgcag caaggccttc tcccagagct 1080
ctgacctcat caaacaccag cgcacccaca ctggcgagcg gccctacaaa tgtccccgtt 1140
gcggcaaggc cttcgccgac agctcttacc tgcttcgcca ccagcgcact cactctggcc 1200
aagcccta caagtgccca cattgtggca aggccttcgg cgacagctcc tacctcctgc 1260
gacaccagcg cacccacagc cacgagcggc cctacagctg caccgagtgc ggcaagtgct 1320
atagccagaa ctcgtccctg cgcagccatc agagggtgca caccggtcag aggcccttca 1380
gctgtggcat ctgcggcaag agcttctccc agcggtcggc ccttatcccc catgcccgca 1440
gccacgcccg ggagaagccc ttcaagtgcc ctgagtgcgg caagcgcttt ggccagagct 1500
cggtgctggc catccacgcc cgcacccacc tgccaggccg cacctacagc tgccccgact 1560
gcggcaagac cttcaatcgc tcctccactc tcatccagca ccagcgctcc cacacgggcg 1620
agcggcccta caggtgcgcc gtgtgcggca agggcttctg ccgctcctcc acgcttctgc 1680
agcatcaccg ggtccacagt ggcgagcggc cttacaagtg cgatgactgc ggaaaggcct 1740
ctcccagag ctccgacctc atccgccacc agcggaccca cgcggcgggc cggcgctgac 1800
ctggggcccc agcaggggtg ggaggtgtgg gcagaagata aggggccagg gagctagagg 1860
aacctttagg gaggatagtg gagaagccgc aggagaatgg aggagctgag gatgctggaa 1920
gaagagaacc agggtggagg aagtgacatg ccctggagac ttgtgggaag tgggttggag 1980
ggaggccagg ccggcagcgg gaggccctgg gagaaatgga gagaggtcag cggagggctg 2040
gcctcagccg cggctccttg gtgggtgcct ggcttggcaa ctgctagagc agggaggggg 2100
gagggcaggg gattacctaa ttagagtggg ttagcttaga ttggtagctg ctgaaactct 2160
cgttgagtca ggagcgggta aaaggtaggt ggggtgggga gtggggcccc ggggtggggc 2220
ctgggcctct gcgtgcaaac cccagcctcc ctcttcttcc tcaggctttg gagcccctga 2280
gtttgagttc aataaaaact ttatgtggt 2309
<210>23
<211>1853
<212>DNA
<213>人
<400>23
cacagggact gcgctccctt gcccctagcg ctcccgcgct gctgctccag ccgcccggca 60
gctctgagga tggagaggag ggcgcggagc tcctccaggg agtcccgcgg gcgaggcggc 120
aggactccgc acaaggagaa caagagggca aaggccgaga ggagcggcgg gggccgcggg 180
ccaggagg ctgggcccga gccgtcgggc tccggacggg cggggacccc gggggagccc 240
cgagcgcccg ccgccacggt ggtggacgtg gatgaggtcc gaggctccgg cgaggagggc 300
accgaggtgg tggcgctgtt ggagagcgag cggcccgagg aaggtaccaa atcctccggc 360
ttaggggcct gtgagtggct tcttgtcctc atttccctgc tcttcatcat catgaccttc 420
cctttttcca tctggttctg cgtaaaggtt gtacaagagt atgaaagagt aattatattc 480
cgactgggac atctgcttcc tggaagagcc aaaggccctg gtcttttctt ttttttgccc 540
tgcctggata cctaccacaa ggttgacctt cgtctccaaa ctctggagat accttttcat 600
gagatcgtga ccaaagacat gtttataatg gagatagatg ccatttgcta ctaccgaatg 660
gaaaatgcct ctcttctcct aagcagtctt gctcatgtat ctaaagctgt gcaattcctt 720
gtgcaaacca ctatgaagcg tctcctagca catcgatccc tcactgaaat tcttctagag 780
gaagagca tcgcccaaga tgcaaaggtt gccttggatt cagtgacctg tatttgggga 840
atcaaagtgg agagaataga aattaaagat gtgaggttgc cagctgggct tcagcactca 900
ctggctgtgg aggctgaagc gcaaagacaa gccaaagtgc ggatgattgc tgcagaagcg 960
gaaaaggctg cttctgagtc cctgaggatg gcagctgaga ttctgtcagg cacccctgct 1020
gctgttcagc ttcgatacct ccacaccctt cagtctctgt ccacagagaa gccttccact 1080
gtggttttac ctttgccatt tgacctactg aattgcctgt cttctcccag caacagaact 1140
cagggaagcc tccccttccc aagtccttcc aaacctgttg agccactaaa tcctaaaaag 1200
aaagactctc ccatgttata ggaaggatgg ggcataatgt gactgtaaag gggcctgcca 1260
tagaaaagtc acatccctga gggagacact ctgtcctcat tccctgccct tcctttggtt 1320
gccatatgga atggccatgg aatgcacgaa gtcacaatgc accatccatg agaagacagt 1380
gaaatgatgt aatgacagag aaggcagaca acatgtttcc gtgactcatc tagtcagagc 1440
aattatggga aacagctttg gtcaacattc tactttggaa agaattttga gtctagatgt 1500
ggttaaattt tgacttctgg gaacttggtt cagatgtccc tttcactgta tgtcctctga 1560
cccctttggc aaggttgcca cagctcccac agcccttcct acaagcacct atcattgggc 1620
ttgtcacact ctattgctct tctgtcccga agatgcagtc ttctctccaa tgatactacc 1680
aagtcttagt tttcctcaac cacactcaat ctttttgctc caccctgaat tcctcacacc 1740
taaccctgat agttacctaa agtgacactt aaatgtttca gagtgaatgc aaaaaagaga 1800
gatgtacttg gagtcggata tacaatttat ccctaattaa agcatttaaa agg 1853
<210>24
<211>765
<212>DNA
<213>人
<400>24
ggcaagcact ttaacctttt aagcccaacc agatgagttg cctgcagttt tggaggcctt 60
cagagcattt cactagacct ctgtctgtgt cggtccagtg tctttagcca agctttgatt 120
aaagatgact tccttgtttg ctcaagaaat tcgcctttct aaaagacatg aagaaatagt 180
atcacaaaga ttaatgttac ttcaacaaat ggagaataaa ttgggtgatc aacacacaga 240
aaaggcatct caactccaaa ctgttgagac tgcttttaaa aggaacctta gtcttttaaa 300
ggatatagaa gcagcagaaa agtcactaca gaccaggatt cacccacttc cacggcctga 360
ggtggtttct cttgagactc gttactgggc atcagtagaa gaatatattc ccaaatggga 420
acagtttctt ttaggaagag caccatatcc ttttgctgtt gaaaatcaaa atgaagcaga 480
aaataccatt caaaatgagg cacagcgata acttcttcac atgctatttc aaaaagcctg 540
tttaataaag ctgaatgtta aggtgtatgt aggttattgc aggaacttta ggaattaaat 600
atgttcatat tcttcgatta tctcctaagt gacagtgaag atatgagaat ttactggcaa 660
gtcacatgtt atcacctact actatttcaa ggtcatgaat ttgctttcta ccaaacccat 720
agatgtgtta aacacgaata ttaaaaggtg gactctttat taatt 765
<210>25
<211>2448
<212>DNA
<213>人
<400>25
acgtcccagc gtctgagaga acgagtaagc acagaattca aagcattctg cagcctgaat 60
tttgaaggag tgtgtttagg cactaagcaa gctgatttat gataactgct ttaaacttca 120
acaaccaaag gcataagaac taggagctgc tgacatttca atatgaaggg caactccacc 180
cttgccacta ctagcaaaaa cattaccagc ggtcttcact tcgggcttgt gaacatctct 240
ggcaacaatg agtctacctt gaactgttca cagaaaccat cagataagca tttagatgca 300
attcctattc tttactacat tatatttgta attggatttc tggtcaatat tgtcgtggtt 360
acactgtttt gttgtcaaaa gggtcctaaa aaggtttcta gcatatacat cttcaacctc 420
gctgtggctg atttactcct tttggctact cttcctctat gggcaaccta ttattcttat 480
agatatgact ggctctttgg acctgtgatg tgcaaagttt ttggttcttt tcttaccctg 540
aacatgtttg caagcatttt ttttatcacc tgcatgagtg ttgataggta ccaatctgtc 600
atctacccct ttctgtctca aagaagaaat ccctggcaag catcttatat agttcccctt 660
gtttggtgta tggcctgttt gtcctcattg ccaacatttt attttcgaga cgtcagaacc 720
attgaatact taggagtgaa tgcttgcatt atggctttcc cacctgagaa atatgcccaa 780
tggtcagctg ggattgcctt aatgaaaaat atccttggtt ttattatccc tttaatattc 840
tagcaacat gctattttgg aattagaaaa cacttactga agacgaatag ctatgggaag 900
aacaggataa cccgtgacca agtcctgaag atggcagctg ctgttgttct ggccttcatc 960
atttgctggc ttcccttcca tgttctgacc ttcctggatg ctctggcctg gatgggtgtc 1020
attaatagct gcgaagttat agcagtcatt gacctggcac ttccttttgc catcctcttg 1080
ggattcacca acagctgcgt taatccgttt ctgtattgtt ttgttggaaa ccggttccaa 1140
cagaagctcc gcagtgtgtt tagggttcca attacttggc tccaagggaa aagagagagt 1200
atgtcttgcc ggaaaagcag ttctcttaga gaaatggaga cctttgtgtc ttaaacgtga 1260
gagcaaaatg catgtaatca acatggctac ttgctttgag gctcaccaga attattttta 1320
agtggtttta ataaaataat aaaatttccc ctaatctttt ctgaatcttc tgaaaccaaa 1380
tgtaactatg ttttatcgtc cagtgacttt caggaattgc ccattgtttt tctgatatgt 1440
ttgtacaaga tttcattggt gagacatatt tacaacctag aagtaactgg tgatatatct 1500
caaattgtaa ttaataatag attgtgaata atgatttggg gattcagatt tctctttgaa 1560
acatgcttgt gtttcttagt ggggttttat atccattttt atcaggattt cctcttgaac 1620
cagaaccagt ctttcaactc attgcatcat ttacaagaca acattgtaag agagatgagc 1680
acttctaagt tgagtatatt ataatagatt agtactggat tattcaggct ttaggcatat 1740
gcttctttaa aaacgctata aattatattc ctcttgcatt tcacttgagt ggaggtttat 1800
agttaatcta taactacata ttgaataggg ctaggaatat agattaaatc atactcctat 1860
gctttagctt atttttacag ttatagaaag caagatgtac tataacatag aattgcaatc 1920
tataatattt gtgtgttcac taaactctga ataagcactt tttaaaaaac tttctactca 1980
ttaatgat tgtttaaagg tttctatttt ctctgatact tttttgaaat cagtaaacac 2040
tgtgtattgt tgtaaaatgt aaaggtcact tttcacatcc ttgacttttt agatgtgctg 2100
ctttgatata taggacattg atttgatttt tattattaat gctttggttc tgggttgttt 2160
cctaaaatat ctgggtggct taaaaaaaac tctttaactt gtaataaacc cttaactggc 2220
ataggaaatg gtatccagaa tggaattttg ctacatgggg tctgggtggg ggcaaagaga 2280
cccagtcaat tacatgtttg gtaccaagaa aggaacctgt cagggcagta caatgtgact 2340
ttgaaaatat ataccgtggg ggtagtttta ccctatatct ataaacactg tttgttccag 2400
aatctgtatg attctatgga gctattttaa accaattgca ggtctaga 2448
<210>26
<211>1101
<212>DNA
<213>人
<400>26
atggatttct taaattcatc tgatcaaaac ttgacctcag aggaactgtt aaacagaatg 60
ccatccaaaa ttctggtgtc cctcactctg tctgggctgg cactgatgac aacaactatc 120
aactcccttg tgatcgctgc aattattgtg acccggaagc tgcaccatcc agccaattat 180
ttaatttgtt cccttgcagt cacagatttt cttgtggctg tcctggtgat gcccttcagc 240
attgtgtata ttgtgagaga gagctggatt atggggcaag tggtctgtga catttggctg 300
agtgttgaca ttacctgctg cacgtgctcc atcttgcatc tctcagctat agctttggat 360
cggtatcgag caatcacaga tgctgttgag tatgccagga aaaggactcc aaagcatgct 420
ggcattatga ttacaatagt ttggattata tctgttttta tctctatgcc tcctctattc 480
tggaggcacc aaggaactag cagagatgat gaatgcatca tcaagcacga ccacattgtt 540
tccaccattt actcaacatt tggagctttc tacatcccac tggcattgat tttgatcctt 600
tactacaaaa tatatagagc agcaaagaca ttataccaca agagacaagc aagtaggatt 660
gcaaaggagg aggtgaatgg ccaagtcctt ttggagagtg gtgagaaaag cactaaatca 720
gtttccacat cctatgtact agaaaagtct ttatctgacc catcaacaga ctttgataaa 780
attcatagca cagtgagaag tctcaggtct gaattcaagc atgagaaatc ttggagaagg 840
aaagatct caggtacaag agaacggaaa gcagccacta ccctgggatt aatcttgggt 900
gcatttgtaa tatgttggct tccttttttt gtaaaagaat tagttgttaa tgtctgtgac 960
aaatgtaaaa tttctgaaga aatgtccaat tttttggcat ggcttgggta tctcaattcc 1020
cttataaatc cactgattta cacaatcttt aatgaagact tcaagaaagc attccaaaag 1080
cttgtgcgatgtcgatgtta g 1101
<210>27
<211>6103
<212>DNA
<213>人
<400>27
atccggggca gcggggaatg gctgagccag gggttcgccg cccccgccgc cgccgccgcc 60
gccgccgccg ccgccgccgc ccgctttcgg ctcgggcctc aggaccgtag catcctgaga 120
cattttgaat tgacacttct caagatttga ctggatcaga gttcatcatg tcaaagttga 180
aaagctcaga gtcagtcagg gtggtggttc gctgtcggcc catgaatggc aaggaaaagg 240
ctgcttcgta tgacaaagtg gtggatgtgg atgttaagct ggggcaggtg tctgtgaaga 300
accccaaagg gacggcccat gaaatgccca agaccttcac ctttgatgcc gtctatgact 360
ggaatgccaa gcagtttgaa ctgtacgatg agacgttccg accacttgtt gactctgtcc 420
tgcaaggttt caatggaacc atttttgcct atggacaaac tgggacagga aaaacctaca 480
ccatggaagg aatccgtggt gaccctgaaa aaagaggagt cattcctaac tcatttgacc 540
atatcttcac ccacatctct cgatcccaga atcaacaata cctggtcagg gcttcttact 600
tagagatcta ccaggaggag atccgagatt tgctctcaaa ggatcagacc aaaaggcttg 660
agctcaaaga gaggcctgac acaggagtgt atgtgaaaga cctgtcttcc tttgtcacca 720
agagtgtgaa ggagatagag catgtgatga atgtggggaa ccagaaccgt tctgtcggtg 780
ctaccaacat gaacgagcac agctcgcgtt ctcatgcaat tttcgttatc actattgagt 840
gcagcgaggt gggcctcgat ggtgaaaacc acatccgtgt aggaaaattg aaccttgtag 900
atcttgctgg cagcgaacgg caagccaaga ccggcgcaca aggggagaga ttaaaagaag 960
ctaccaagat caacctctcc ctttccgctt tgggtaatgt catctctgct ctagtggacg 1020
gcaaaagcac tcacattcca tatcgggact caaagcttac caggctcctc caagattccc 1080
ggtggcaa tgccaagact gtgatggtgg ccaacgtggg gcctgcctct tacaacgtag 1140
aagagactct gaccactctg cgatatgcca accgtgccaa aaacattaag aacaaaccaa 1200
gggtcaatga ggaccccaag gatgccctcc ttcgagaatt ccaggaagag attgctcggc 1260
tcaaggccca gctggaaaaa cggtccattg gtaggaggaa gaggcgagag aagcggaggg 1320
aaggtggtgg cagtggtggg ggtggggaag aggaggagga ggagggagaa gagggtgagg 1380
aggaagggga tgataaggat gattactggc gggaacagca agaaaaactg gagattgaga 1440
agcgggccat tgtagaggat cacagcttgg ttgcagagga gaagatgagg ctgctgaagg 1500
agaaagagaa aaagatggag gacctgcggc gggagaagga tgctgccgag atgctgggcg 1560
ccaagatcaa ggccatggag agtaagttgc ttgttggagg aaaaaatata gtagatcata 1620
cgaatgaaca gcagaaaatc ctggagcaga aacgacagga aattgcagag cagaaacgtc 1680
gagaaagaga aatccagcaa cagatggaaa gtcgagatga ggagaccttg gaacttaaag 1740
agacatacag ctcattgcag caagaggtgg acatcaagac caaaaaactc aaaaagctct 1800
tctccaagct tcaggcagtg aaggctgaga tccatgacct ccaagaagaa cacatcaagg 1860
agcgccaaga gctagagcag actcagaatg agctcaccag ggagctgaaa ctcaagcatc 1920
ttattataga aaactttatc cctctggaag aaaaaagtaa aattatgaat agagccttct 1980
ttgatgaaga ggaagatcat tggaaactac atcctataac cagactggag aaccagcaga 2040
tgatgaagcg gccagtctca gccgtgggat ataagagacc attgagccag cacgcaagaa 2100
tgtccatgat gattcgtcca gaggcccgat atagggcaga aaacattgtg ctgttagagc 2160
tggacatgcc cagccggacc accagagact atgagggtcc agccattgcc cccaaggtcc 2220
aggctgcatt ggatgcggct ctgcaggatg aagatgagat acaggtggat gcatcatcat 2280
ttgaaagcac tgcaaataag aaatccaagg ccaggcctaa aagtggaagg aagtcgggat 2340
cctcctcctc ttcctcagga acccctgcat ctcagcttta tccacagtct cgggggctgg 2400
ttccaaagta aagccagctt ctcctctccc agggcggaaa cagcatttgc cttctgagag 2460
aagagactag caaaaagctg cagagaggat tcggcccaaa ctcagaactg ttcccctgag 2520
gagaagcggt ggcctctttg cagatcaacc aacttaatct ggttgaacgt gctgttccta 2580
atctggcact cagcccctct gggaaacatc ttttaattag catctcagaa atgcatgggt 2640
aaggtaaagt gcgatagttc aagtggaaag caagagaatg accagtgacc ttgcttcctt 2700
cccccttgcc ttcttctccc ccttcccctg tgctcccttt ctctcctctc tccttttcta 2760
ctgttctt tacatggggc tcccttcttg ttgaacaata gggcagaatc aggagtcacc 2820
ttagcaggac cacatctttg gagcctcggg ataaaatgac agtgaggttg aaaagtgaaa 2880
accctagaac ttgaataggt gcctgttctt gtagggagaa atgagaaatc gcatttggat 2940
ccaggcccca ggtgggcacc atcagcagtc ttgcttccat gcacctcagt aagaagtgga 3000
tctgcctttg ggacctgctc agtgaggaaa tctcttccaa tttctgcttc tgaatgattc 3060
aatgttggga gcaatagaaa taacattccc tttgccttct ctgagtgttt agggaaatag 3120
cttctttaaa acctcaaaac catgaccatc ctgtcaaaga cctaagtctg taagctggtg 3180
ccatgtccat acaccatgtc actttactct tcatttgtca ccatcttttc ccatgcacgc 3240
atactctgaa catccttgtg tgggcccatc ctctgcatcc agagcatgct ctgcagtggg 3300
cctgttttgt ggaagaaagg aggctgtctc tgccttctct gatgggactg gagttgaggg 3360
aaggagctgt attgtggcac ttctgaattc cccgttttgt tccatattgg tatagagagc 3420
agaagagtag ctaggcagat gcagagatgg agacatgaga ctcagtgcag tgggcaggga 3480
agacataaca gatggaagca aaggaatcct gcctgccttc agcagagaat tcaccgaatc 3540
ctagaactgt ggctccctcc aggcagagcc taagatgctg gtgaagaata gctgtgtgat 3600
tgaataggct caaaggagag ttcagaattc ccatttacat attactagtt tggtttgtaa 3660
gttttagttc cttgtattat tgagattcag agcttcattt tatgttggtc attaggtgaa 3720
tattactcat tttccctcaa gagaagctca taagtgtgtg tgggtgtgag agcacgatgg 3780
tgcctgtgtt ctgtgaatgt gtccatatgt gtctgtaaga gagacagaga ccaagaactt 3840
gcccaatttt agaaatacac taatgtgcag ttgttgcctt ttgtctgtat tgaaggccca 3900
ttgaatgact aatccaggct ggaagcattc ccatgtgggt gtctgagtcc atgagccaag 3960
cctgagggga cagtgagtct ccaggtctgc cacactggtg caccttgctg gcacggtgcc 4020
tcaggaaggt ggcgactcag gtgggccttg agttatattt taactcagct gctcagttcc 4080
cagggcacat ttctggatca gaacccatgg gaaacaggag gtactaagtg caatgtctta 4140
gcattctgca aaatggagat ctgttgtcca gcggcttatc tcctttttag taacccttct 4200
ttctgaaccc agggcccttt tcagccttcc ctcatatttt cttgagatca aactttactt 4260
ctttcttatt tactaagaat ttgcctgttt gaataagaac aaaacgctaa ggtgggtagc 4320
ctaagctgat tttctgctgg ttacacgtgt ctctcacacc acatttcctc aaagctaatc 4380
tgaattctgt aggctaaaaa tattcatgta gcaaatctga gaattgaaaa ctgcagataa 4440
ccggccgggt atggtgactc atgcctgtaa tcctagcact ttgggaggcc gaggtgggtg 4500
ccacctga ggttaggact tcaagaccag cctggccaac atggtgaaac cccatctgta 4560
ctaaaaatac aaaaatttgc ctggtgtggt ggtgcatgcc tctagtccta gctactcggg 4620
aggctgaggc acgagaatca cttgaacctg ggaggcggag gttgcagtga gtcgagataa 4680
cactactgca ttccagcctg ggtgacagag tgagactcca cctcaaaaaa aaaaaaaaaa 4740
aaaaaaaaaa cagaaagaaa gaaaaagaaa actgcagata accctataca ttaatactgg 4800
tatctcgagg tgactcttct gaccaagggt ggttaagtga cacatagaac ttttctaaga 4860
gaagacagac aagttgacag gcatgccttg tactcagctg tgttcatgtg gtggtctgtg 4920
gaaagaaaag aagactcatt tggaaatgaa gctgtccctt tccaagcagt ctctggtgct 4980
tttcttctct caaaatggat ccgataaata tttgaataga gcagattgta gaatgtcgtg 5040
tgtcaccag aaagctgctg ttttgggttc tgcattgagc caaatatgta gaggacctac 5100
caagcccact gagggactag gttttcatgt ctctagtcat acctagaatg ttctgagccg 5160
tctgagggcc ttcatgccgg cagcagctag caaagccaga aagcaagtct aacaggatct 5220
aagatgacca tcaggagaag gagtttgaga ctgtgtatgc aacccccaat agaccccctt 5280
ttactctgat ctggagaatg tatctggctt catattttca agtcacatgt ctctcagacc 5340
cctggattca gaacccaagg ccacaaatca taggcatgaa gcactttctt aagactgacc 5400
taacgctgga ttatttcccg tccaatgcct gcatgctgct tgaattgctc cacccacacc 5460
tccatgacca agggcgccag agtgctgcaa ctggggcgtg ggccgctctc tgcttttcct 5520
gtctgactct gacaagtcct ccctcactga atgtagaatc gttgccaagt ttctgagaag 5580
tgtcgattcc ctgttaacat ggatatcagt tctgcctcac atttcccact tgaggttgag 5640
gcgtactgga gacaacacct cagaccatct gaaccccatc agtggacgaa aatggggctg 5700
ttaatatact ctaaaagcca tactaaaaat gctctgaggg aactggctaa gaatagtggg 5760
cctggtgatt gtctatcacg caaggctttg ttttgtactg ttcagaaatc tgtcaccttt 5820
ctgcctgccc ttgtttcctg aatgaaatgc ttctggggtt atttatgaaa ggagtgatcc 5880
tggggcaggc aggaggcagt gggcttcatg gctccttgaa gttattactg atcttgacct 5940
tctctttggc tacctttaga caaagaatac gccaatcaat acttggggct ctaagtttta 6000
caattgatat ttatttgtat catctctttg tctaggaatg taaaagtgat tctaaactaa 6060
gatgtgtaat aaaaatcaat cagatttatt gtacctacaa aaa 6103
<210>28
<211>1318
<212>DNA
<213>人
<400>28
atgaaggcca ctatcatcct ccttctgctt gcacaagttt cctgggctgg accgtttcaa 60
cagagaggct tatttgactt tatgctagaa gatgaggctt ctgggatagg cccagaagtt 120
cctgatgacc gcgacttcga gccctcccta ggcccagtgt gccccttccg ctgtcaatgc 180
catcttcgag tggtccagtg ttctgatttg ggtctggaca aagtgccaaa ggatcttccc 240
cctgacacaa ctctgctaga cctgcaaaac aacaaaataa ccgaaatcaa agatggagac 300
tttaagaacc tgaagaacct tcacgttgtc taccttcata acaacaatat ctctgtagtt 360
ggatcaagtg acttctgccc acctggacac aacaccaaaa aggcttctta ttcgggtgtg 420
agtcttttca gcaacccggt ccagtactgg gagatacagc catccacctt cagatgtgtc 480
tacgtgcgct ctgccattca actcggaaac tataagtaat tctcaagaaa gccctcattt 540
ttataacctg gcaaaatctt gttaatgtca ttgctaaaaa ataaataaaa gctagatact 600
ggaaacctaa ctgcaatgtg gatgttttac ccacatgact tattatgcat aaagccaaat 660
ttccagttta agtaattgcc tacaataaaa agaaattttg cctgccattt tcagaatcat 720
cttttgaagc tttctgttga tgttaactga gctactagag atattcttat ttcactaaat 780
gtaaaatttg gagtaaatat atatgtcaat atttagtaaa gcttttcttt tttaatttcc 840
aggaaaaaat aaaaagagta tgagtcttct gtaattcatt gagcagttag ctcatttgag 900
ataaagtcaa atgccaaaca ctagctctgt attaatcccc atcattactg gtaaagcctc 960
atttgaatgt gtgaattcaa tacaggctat gtaaaatttt tactaatgtc attattttga 1020
aaaaataaat ttaaaaatac attcaaaatt actattgtat acaagcttaa ttgttaatat 1080
tccctaaaca caattttatg aagggagaag acattggttt gttgacaata acagtacatc 1140
ttttcaagtt ctcagctatt tcttctacct ctccctatct tacatttgag tatggtaact 1200
tatgtcatct atgttgaatg taagcttata aagcacaaag catacatttc ctgactggtc 1260
tagagaactg atgtttcaat ttacccctct gctaaataaa tattaaaact atcatgtg 1318
<210>29
<211>1313
<212>DNA
<213>人
<400>29
ggggggcgca gcaggccagg gcaacccgcc gcgaggcggc gtccacgccg aggagccgcg 60
cattcccggt ccacacagac gcggcggagc gccctcccag gcgggactac aactcaatgc 120
ctggcacggg ggcgggctcg gcggtgactt aatccgggct gagtttggtg gtggtagtga 180
gggcaggtag gggcactgcc cattttggcc aagggtcaca cagcatctac atcacaattg 240
caccggagtt taaaaatgtc tggccctgtc cctccccacc acccgccgct gtgtccagac 300
gagaatgtt ctaacgctgg gggcggctgc ggatgaagtc cttggggaga aaaggagcag 360
gccaagggcg atggtggagt agagctgcct ctcagaggca gcatgagctg agagggtgat 420
aggaaggcgg cgctagacag catggaggac tttctgctct ccaatgggta ccagctgggc 480
aagaccattg gggaagggac ctactcaaaa gtcaaagaag cattttccaa aaaacaccaa 540
agaaaagtgg caattaaagt tatagacaag atgggagggc cagaagagtt tatccagaga 600
ttcctccctc gggagctcca aatcgtccgt accctggacc acaagaacat catccaggtg 660
tatgagatgc tggagtctgc cgacgggaaa atctgcctgg tgatggagct cgctgaggga 720
ggggatgtct ttgactgcgt gctgaatggg gggccactgc ctgaaagccg ggccaaggcc 780
ctcttccgtc agatggttga ggccatccgc tactgccatg gctgtggtgt ggcccaccgg 840
gacctcaaat gtgagaacgc cttgttgcag ggcttcaacc tgaagctgac tgactttggc 900
tttgccaagg tgttgcccaa gtcacaccgg gagctgagcc agaccttctg cggcagtaca 960
gcctatgctg cccccgaggt gctgcagggc attccccacg atagcaaaaa aggtgatgtc 1020
tggagcatgg gtgtggtcct gtatgtcatg ctctgtgcca gcctaccttt tgacgacaca 1080
gacatcccca agatgctgtg gcagcagcag aagggggtgt ccttccccac tcatctgagc 1140
atctcggccg attgccagga cctgctcaag aggctcctgg aacccgatat gatcctccgg 1200
ccttcaattg aagaagttag ttggcatcca tggctagcaa gcacttgata aaagcaatgg 1260
caagtgctct ccaataaagt agggggagaa agcaaaccca aaaacccgct tct 1313
<210>30
<211>3401
<212>DNA
<213>人
<400>30
atgaggaggt cgctgagagc tgggaagagg cggcagacag cggggaaatc caaatctcct 60
cccaaagtgc ccattgtgat tcaggacgat agccttcccg cggggccccc tccacagatc 120
cgcatcctca agaggcccac cagcaacggt gtggtcagca gccccaactc caccagcagg 180
cccacccttc cagtcaagtc cctagcacag cgagaggccg agtacgccga ggcccggaag 240
cggatcctgg gcagcgccag ccccgaggag gagcaggaga aacccatcct cgacaggcca 300
accaggatct cccaacccga agacagcagg cagcccaata atgtgatcag acagcctttg 360
gtcctgatg ggtctcaagg cttcaaacag cgcagataaa tgcaggcaag aaaagatgcc 420
gccgttgctg ccgtcaccgc ctcctgggtc gtccgccacg ggttgcactg ccgtggcaga 480
cagctggact tgagcagagg gaacgacctg acttacttgc actgtgatcc cccttgctcc 540
gcccactgtg accttgaacc ccatgcactg tgacctcccc ccttctcccc cttcccactg 600
tgattggcac atcgacaagg gctgtcccaa gtcaatggaa agggaaaggg tgggggttag 660
gggaaggttg gggggaccca gcaaggactc agagagtcag acagtgccac ttggccactt 720
ggggtaaagc cagtgccagc aataacagtt tatcatgctc attaatttgg gatttcaaaa 780
cacaaatgaa aactcacacc cacccacccc caagtgcatg tctccatcac ttaaaaagta 840
agttccattt gaaaatatcc tttctttttt ttttcttcct atttttgttt gtttatacaa 900
atatctgatt tgcaagaaaa agtgcatggg aggggtttta gtggtttaat gaatttttaa 960
ttaagaaagg gtagtttggt agtctactta aaaatgtttc tgggaaattc actagaaaca 1020
ttaaccaata ggattttggt gagcttagct tctgtattcc tactgccgcc cagaaaaggg 1080
gcagggctct gcagccgcca ggacagacga gcaccccatg cctatacctc cctccccgag 1140
ctaagtccca gggcatctgg gccttgcctg gagactgggc tagctctgta ggctcggaga 1200
gcctggggag ggtgccaacc ccacctctag tattttggga gatagggaaa gtgaaccgac 1260
ttccccttcc catacccctc agggtggttc cctaccagcc aggcttacta cttctagaag 1320
aaagcagagt gccagggagt gagattgcat ccctgggctt agaagtgacg gagagaagac 1380
ttgtttagta ttttgccatc agcacaagga aaaccaggag agagtctgcc tccaggactc 1440
tgagccttct gcctcatatg ttcagaaggt ggataggtct tcccactcca gcatggcttg 1500
ctcttagg ggtctgcagt gctccatctc cattggtggc cccagctcag taactatacc 1560
tggtacattt cctgtgtgca atcagtacct tgaaggcaga acattctgaa taaagttgga 1620
aaaagaacag ctttgctttg caaagattga tgacagactg gttcctcaga ggcctaggct 1680
acccgtcacc cctttttcca gagcgagggc ctggaatgaa ggcagtttat cctctgtccc 1740
tggagcctgg ggtttgcttt ggctccttga ggtggaagag actaagaggg cagctgccca 1800
gagcagctgt gtgtacctgg ctcctctcag gcttcctgat cccttccgtt gcactgcgcc 1860
ttatccctca gccagccaga cagcctccct gctcctgacc agcagatacg tttcggagtg 1920
gttggtgtgg tttttgtgat gagggcagca cgtggtggcc aaggtggcaa gctgagtctc 1980
acaggctcac tccctcgttg gttccctgtg ggaatggtag gccaggccca gtaagccatg 2040
cccaacacg tcctctcctc cggaggaagg gccagctgcc agctgagtca gcagctagtc 2100
catagcacag ccttataact gtaaagccag gcattgccca tgagcagagc tggaaccaga 2160
gcttcagtca gtaagaggga ggattacctt caggagaagg caaggaagaa aactggctgc 2220
tatctttata gttccactgc cctaaccaag tgtccacatt ctaaatgtgt agtgtccatc 2280
ccttatgtaa tagtggtttc ccgcccaaag tgagactttc cttttaattg gagaagggta 2340
tagaggtagt ccaggtggga acgccagaag tgctgattgc ccagccattg ggaccacctg 2400
ttcttgcccc actaccctct agtgggaggc caaagtaaag gctggctggt gggtgtctgt 2460
ggattgagga tgtggcaggg actggtcctc ccacctccct ctggccaaag atgggctttg 2520
cccgctgtgt gcctgtcacc acccaccagc agtcatgccc tgggcttccc aaatggagag 2580
gtagcaggca acgtttttaa aaagaaagaa aacaggaaac tgtattgtgt cgggggaggc 2640
gggagggaga tgaggaaacg gtttggattt tgtgtgtggg agggtatttt ttgggggtag 2700
ttgtctgtaa ctttcctaag tgcttttttt ccttttcttt tttaaagtaa gttgcaggct 2760
ttggcttgga aaaccccagg gggatggggg gcagaaacct gaggctgctg cccctttatc 2820
tgccttcacg gtactgtccc cttcccccag ctcctccctg accccatggg ccaggcctca 2880
gaccttccag ctaaccgctt cccatgagcc actactctga tgtcagccta taaccaaagg 2940
agctgggggg tccaggcctg gtgaccaacc tttctcagcc cactcaatca gggtgctccc 3000
cacctgcagg caggaggcaa caccctatct gctaccatca gccccttcca gagcccatct 3060
gccccgccca gccctgccct gcccagccat accctgctct gccccatctg ggggtgccct 3120
gctcagggat gggctggcag ggctgtaccc agcctccctg gtaagcagag actcaagaaa 3180
tctggggt cctgttttct ggtcgtgtga tcccaggggt gcacatgggc cccttgggtg 3240
tctgaacaga agggcatggg agggagggct gcacccctgc agtcttactc tgctggtgta 3300
gcgggcagct gcccactccc accccaccct gcaccgcggg ctcctgagtc ggcagattaa 3360
gcattttata aattgtattt taaatacatg ttttaaactt g 3401
<210>31
<211>5470
<212>DNA
<213>人
<400>31
gattgccccc tgtgggtcac tttctcagtc attttgagct cagcctaatc aaagactgag 60
gttatgaagt cgatcctaga tggccttgca gataccacct tccgcaccat caccactgac 120
ctcctgtacg tgggctcaaa tgacattcag tacgaagaca tcaaaggtga catggcatcc 180
aaattagggt acttcccaca gaaattccct ttaacttcct ttaggggaag tcccttccaa 240
gagaagatga ctgcgggaga caacccccag ctagtcccag cagaccaggt gaacattaca 300
gaattttaca acaagtctct ctcgtccttc aaggagaatg aggagaacat ccagtgtggg 360
gagaacttca tggacataga gtgtttcatg gtcctgaacc ccagccagca gctggccatt 420
gcagtcctgt ccctcacgct gggcaccttc acggtcctgg agaacctcct ggtgctgtgc 480
gtcatcctcc actcccgcag cctccgctgc aggccttcct accacttcat cggcagcctg 540
gcggtggcag acctcctggg gagtgtcatt tttgtctaca gcttcattga cttccacgtg 600
ttccaccgca aagatagccg caacgtgttt ctgttcaaac tgggtggggt cacggcctcc 660
ttcactgcct ccgtgggcag cctgttcctc acagccatcg acaggtacat atccattcac 720
aggcccctgg cctataagag gattgtcacc aggcccaagg ccgtggtggc gttttgcctg 780
atgtggacca tagccattgt gatcgccgtg ctgcctctcc tgggctggaa ctgcgagaaa 840
ctgcaatctg tttgctcaga cattttccca cacattgatg aaacctacct gatgttctgg 900
atcggggtca ccagcgtact gcttctgttc atcgtgtatg cgtacatgta tattctctgg 960
aaggctcaca gccacgccgt ccgcatgatt cagcgtggca cccagaagag catcatcatc 1020
cacacgtctg aggatgggaa ggtacaggtg acccggccag accaagcccg catggacatt 1080
aggttagcca agaccctggt cctgatcctg gtggtgttga tcatctgctg gggccctctg 1140
tgcaatca tggtgtatga tgtctttggg aagatgaaca agctcattaa gacggtgttt 1200
gcattctgca gtatgctctg cctgctgaac tccaccgtga accccatcat ctatgctctg 1260
aggagtaagg acctgcgaca cgctttccgg agcatgtttc cctcttgtga aggcactgcg 1320
cagcctctgg ataacagcat gggggactcg gactgcctgc acaaacacgc aaacaatgca 1380
gccagtgttc acagggccgc agaaagctgc atcaagagca cggtcaagat tgccaaggta 1440
accatgtctg tgtccacaga cacgtctgcc gaggctctgt gagcctgatg cctccctggc 1500
agcacaggaa aagaattttt ttttttaagc tcaaaatcta gaagagtcta ttgtctcctt 1560
ggttatattt ttttaacttt accatgctca atgaaaaggt gattgtcacc atgatcactt 1620
atcagtttgc taatgtttcc atagtttagg tactcaaact ccattctcca ggggtttaca 1680
gtgaagaaag cctgttgttt aagtgactga acgatccttc aaagtctcaa tgaaatagga 1740
gggaaacctt tggctacaca attggaagtc taagaaccca tggaaaaatg ccatcaaatg 1800
aataatgcct ttgtaaccac aactttcact ataatgtgaa atgtaactgt ccgtagtatc 1860
agagatgtcc atttttacaa gttatagtac tagagatatt ttgtaaaatg tattatgtcc 1920
tgtgagatgt gtatcagtgt ttatgtgcta ttaatatttg tttagttcag caaaactgaa 1980
aggtagactt ttatgagaac aatggacaag cagtggatac gtgtcaatgt gtgcactttt 2040
tttctatatt attgcccatg atataacttt agaaataaac cttaatattt cttcaaatat 2100
ctctatttaa ttttgacact gaaataaccg taaaggttta tttttctgtt acctcaacaa 2160
gaagaatttg aagacttcaa aatattgagc agaattcatt catacttaaa aatttattag 2220
ccctgcattt tcataggaag acacattatc ttctggacta tagctgttct aatggattat 2280
aatcagaatg gaagagagaa agcatattga ctttttttga gcgacatctc tgactttctt 2340
tagtctttag ctattactgg atctcttaag acagcatgtg ttaatcttaa tgtatatcgt 2400
tatcactgtg cagttgctgt ttacttgaat agtattgtgt tcctatattc caggtttaag 2460
tagatttcat gcctgggtgg ccaaacaaca gtcttcattt tttttaattg aaaagaagta 2520
gtgtctggat cagtaaaatt atactgtgtg tgagtgtgaa tataaatgtg tgtatgtgtg 2580
tttctgtcct gtaactgtta cagtaatgtc ataaagtgag aaaactgtga ccaagtataa 2640
acttttacca cttgctgcac tcttgcacat ggattcagtt tctaaaattg agttcttcct 2700
gtaatcttgt tgataaaaat actgactcca accattcaaa aatttcaccc catccctcct 2760
taagagattg gatcaagtat tactaaattg acctttaggt attacacaag accagtgctt 2820
caaaaaat aatgacaggc atccaaggaa gggatgtatt tgtagtgtta ttgccaggaa 2880
aggagagtac tttggtttct gagcaccgaa tattgagcaa tatgtcagtc actaaaagga 2940
agacagttct acagaaaaac aatggtaaca tttttcaata gcgtgtgtag atagtatgca 3000
ctatatacat cacgttaaag taggactatc acacccagcc catgtggcta aaaaagctga 3060
atcagacagt ggatgagaca cacaacggca gtgaagaacc gatacacttg gcattgacgt 3120
ctagctatgc tgtatctgtg ctttgcccac atgcccttgg tgacagctga gcacccagct 3180
ctgtcttggt aggtttgggc taaggaacaa atctctcctt tgctcgtggt tagcaagata 3240
cactcaagca tgaagataaa cacagctgct ttcttcttac accccggtct catgctcctt 3300
aatggcgcca tgggtgcttg ttgggccttt ttccagtaag gaatgatatt gctgaagaat 3360
ctacttaacc ctgacaaatt ttaattataa tctcttctta tacagataaa acatgactcc 3420
acaaggccc caaggtttac atagtctgaa gtgaagtaca gagctggcat ctatctggtg 3480
atttctagct ctcgagatac ccaagcagcc tgatggggca gttccccttc ttacggttca 3540
cgctctaagg caggatgtgg cttatgagat actttgcatt gtctgtctgc acaccttgaa 3600
tctgcctgct ggctccctta ctttacctct ctgtcatgtg cagatgaagg ctcagggtgc 3660
tagaggatta gtaagatctc tttctaaaga caggagagat tatttacaag aagaactcac 3720
cagggtttag tttgcattta agaattgcca gtcttttgtc ctgcatcatc ttgaacatta 3780
atccacatgt ttcagagctc accaggcagt accaatgctc ttttcacagc tatgaagagc 3840
tagagaaatt cttgttatgg tagaaaaatt tcacgattca tttttgaaac tgcatttgtg 3900
cgtatgcagt gtagatttta tagtgtgttg tgctttcaag atctaaatca tatataataa 3960
attaagggac aatggggctg acagcactaa acttggtgct tattgatatt ctaagaaata 4020
tctgtgaaat atcatcacgt atgttataca accttcattt aaaaaggttt aaaactagtt 4080
agattcactt tgacactttt catatcattt cttaacccaa gtgacgaaaa cattgtcccc 4140
aatgaatata ctcattagaa ttaccatttg ttaatatcac tcattaatta accccataat 4200
tagatccatt aatttaaatg atttaaattt aagtaagttt tataaggtct gacatcagag 4260
gtatcttact ttcctctgag gatgatgtac ttgccctgac catgcatttt accatcacac 4320
atgttcagaa agggccaaat tcccaacctg ctcatttttt ttttatcaga gtcatgatga 4380
atcagtccta gaatgtttca tttgcacaag tagggctgcc tccaagagga acctctgatt 4440
tattttgtat gaaatatatg tgaaaggata tgaatctgag agatgctgta gacatctgtc 4500
ctacacttga gatgatttcc aagcctctct ggcactttga gttaagtcta tctggtatta 4560
tgccaagg accttttgct gcctaaatcc actctgcagg aaataggccc aaccaccaga 4620
tgagaattag gccctggatg agtagcgcta tagttactgt cctgttgatt aatttctgcc 4680
atttcatgtc cataaaagag accacccata tcatgcacac aattagattt ctcacactct 4740
aactgtatat ttgtatgata ttttaaaatc tcctaaatgc tgggcaatgg ctattaacaa 4800
ttaattgtct tgcactggcc ttctgatgaa atgttaacaa tgcctattgt aatatagaaa 4860
aaaacattct atctactgat ttgggctgaa tgtatgtaaa taggtttcta aaaagtcaga 4920
tgtttgagca gtggcctaca aatcagtaat tttcggatgg gagagtttct ttacattgcc 4980
gtggcatctt aaaagctatc ttcatgtaaa ttgactgtac taggcctact ggggatcaga 5040
gttcccaaga aaggaaacct tttcttgtat ctggattcaa atttatttcc aatgtttcaa 5100
cgggaaaca tgactcttta ttgtctgtaa atctaacatt attacttttc ctcttagaag 5160
aatattgtat tgttagatgt ttgttgagct ggtaacatcg ttgcaaccac tgcaatatct 5220
tcgttagtaa tctgtataat actttgtata caagtactgg taagattgtt attaaatgta 5280
gcttcagtca ttaaattact atagcaaagt agtacttctt ctgtaatatt tacaatgtat 5340
taagcccaca gtatatttta tttcaatgta attaaactgt taacttattc aaagagaaaa 5400
catctcatca tgtctattgt ccaaagttac ctggaatcaa ataaaaattc tagattacca 5460
tgaagaacat 5470
<210>32
<211>1517
<212>DNA
<213>人
<400>32
gcggcgcgga gggcgcgggc ccgggagcca gggagcgagc ggggcgcccg gcagcgcgga 60
gtcagcgccg cgggggccgc acccgactcg cgcctggaca ctcgcggggc gccgacctgg 120
cagggggcca aaccagtgct cctgccacct ctctggctgc cccctagagc ctgcccatcc 180
cagcctgacc aatgtccaca gccagggagc agccaatctt cagcacacgg gcgcacgtgt 240
tccaaattga cccagccacc aagcgaaact ggatcccagc gggcaagcac gcactcactg 300
tctcctattt ctacgatgcc acccgcaatg tgtaccgcat catcagcatc ggaggcgcca 360
gccatcat caacagcact gtcactccca acatgacctt caccaaaact tcccagaagt 420
tcgggcagtg ggccgacagt cgcgccaaca cagtctacgg cttgggcttt gcctctgaac 480
agcatctgac acagtttgcc gagaagttcc aggaagtgaa ggaagcagcc aggctggcca 540
gggagaaatc tcaggatggc ggggagctca ccagtccagc cctggggctc gcctcccacc 600
aggtgccccc gagccctctc gtcagtgcca acggccccgg cgaggaaaaa ctgttccgca 660
gccagagcgc tgatgccccc ggccccacag agcgcgagcg gctaaagaag atgttgtctg 720
agggctccgt gggcgaggta cagtgggagg ccgagttttt cgcactgcag gacagcaaca 780
acaagctggc aggcgccctg cgagaggcca acgccgccgc agcccagtgg aggcagcagc 840
tggaggctca gcgtgcagag gccgagcggc tgcggcagcg ggtggctgag ctggaggctc 900
aggcagcttc agaggtgacc cccaccggtg agaaggaggg gctgggccag ggccagtcgc 960
ggaacagct ggaagctctg gtgcaaacca aggaccagga gattcagacc ctgaagagtc 1020
agactggggg gccccgcgag gccctggagg ctgccgagcg tgaggagact cagcagaagg 1080
tgcaggacct ggagacccgc aatgcggagt tggagcacca gctgcgggcg atggagcgca 1140
gcctggagga ggcacgggca gagcgggagc gggcgcgggc tgaggtgggc cgggcagcgc 1200
agctgctgga cgtcaggctg tttgagctga gtgagctgcg tgagggcctg gcccgcctgg 1260
ctgaggctgc gccctgagcc ggggctggtt ttctatgaac gattccggcc tgggatgcgg 1320
gccaggctgc aggcggcata gttgggccca ttcgtcctgg aaagggactg gggggtccca 1380
acttagccct gggtgggccg ggccgggctg ggctggggtg ggccccagtc ggctctggtt 1440
gttggcagct ttggggctgt ttttgagctt ctcattgtgt agaatttcta gatcccccga 1500
ttacatttct aagcgtg 1517
<210>33
<211>1228
<212>DNA
<213>人
<400>33
agagatgggg acggaggcca cagagcaggt ttcctggggc cattactctg gggatgaaga 60
ggacgcatac tcggctgagc cactgccgga gctttgctac aaggccgatg tccaggcctt 120
cagccgggcc ttccaaccca gtgtctccct gaccgtggct gcgctgggtc tggccggcaa 180
gcctggtc ctggccaccc acctggcagc ccgacgcgca gcgcgctcgc ccacctctgc 240
ccacctgctc cagctggccc tggccgacct cttgctggcc ctgactctgc ccttcgcggc 300
agcaggggct cttcagggct ggagtctggg aagtgccacc tgccgcacca tctctggcct 360
ctactcggcc tccttccacg ccggcttcct cttcctggcc tgtatcagcg ccgaccgcta 420
cgtggccatc gcgcgagcgc tcccagccgg gccgcggccc tccactcccg gccgcgcaca 480
cttggtctcc gtcatcgtgt ggctgctgtc actgctcctg gcgctgcctg cgctgctctt 540
cagccaggat gggcagcggg aaggccaacg acgctgtcgc ctcatcttcc ccgagggcct 600
cacgcagacg gtgaaggggg cgagcgccgt ggcgcaggtg gccctgggct tcgcgctgcc 660
gctgggcgtc atggtagcct gctacgcgct tctgggccgc acgctgctgg ccgccagggg 720
gcccgagcgc cggcgtgcgc tgcgcgtcgt ggtggctctg gtggcggcct tcgtggtgct 780
gcagctgccc tacagcctcg ccctgctgct ggatactgcc gatctactgg ctgcgcgcga 840
gcggagctgc cctgccagca aacgcaagga tgtcgcactg ctggtgacca gcggcttggc 900
cctcgcccgc tgtggcctca atcccgttct ctacgccttc ctgggcctgc gcttccgcca 960
ggacctgcgg aggctgctac ggggtgggag ctcgccctca gggcctcaac cccgccgcgg 1020
ctgcccccgc cggccccgcc tttcttcctg ctcagctccc acggagaccc acagtctctc 1080
ctgggacaac tagggctgcg aatctagagg agggggcagg ctgagggtcg tgggaaaggg 1140
gagtaggtgg gggaacactg agaaagaggc agggacctaa agggactacc tctgtgcctt 1200
gccacattaa attgataaca tggaaatg 1228
<210>34
<211>2057
<212>DNA
<213>人
<400>34
aaaaaaaaaa acacaggctt gatgctcgct cccgtttcta caggaggttt tgacggctgg 60
atgctgcagg gcatcccctc gcctggagga ggttcacttg tggccaggtt cccagcacac 120
ccacttgctc actggggccc tggggacacc gccacactcg agcccatcct acggcctcaa 180
tccttaccag tccccaggcc atggactgcc acactgtagg tcttcaatca aggtttagtg 240
gtttcgaa tgtacacaca ccctgaaaga cagcgaggcc acctcagaaa acaacgcgcg 300
cccagctggc tcccctccga cagggcccac ggctactggg tcggcctcct ccggaccctg 360
agcacagcct ggtatgcgtg cgggctcgga atacggatct gagcagaaga aatgcgagtg 420
gagagcggtt ctgcgcagga aagaggaatt ttgttggaaa gcctgtcgac gttgctagaa 480
aagaccacag catctcacga ggggcgtgcg ccgggaaacc gggagttgac ggacctcctg 540
ccccccgagg tctgcagtct cctgaaccca gcagccatct acgccaacaa cgagatcagc 600
ctgcgtgacg ttgaggtcta cggctttgac tacgactaca ccctggccca gtatgcagac 660
gcactgcacc ccgagatctt cagtaccgcc cgtgacatcc tgatcgagca ctacaagtac 720
ccagaaggga ttcggaagta tgactacaac cccagctttg ccatccgtgg cctccactat 780
gacattcaga agagccttct gatgaagatt gacgccttcc actacgtgca gctggggaca 840
gcctacaggg gcctccagcc tgtgccagac gaggaggtga ttgagctgta tgggggtacc 900
cagcacatcc cactatacca gatgagtggc ttctatggca agggtccctc cattaagcag 960
ttcatggaca tcttctcgct accggagatg gctctgctgt cctgtgtggt ggactacttt 1020
ctgggccaca gcctggagtt tgaccaagca catctctaca aggacgtgac ggacgccatc 1080
cgagacgtgc atgtgaaggg cctcatgtac cagtggatcg agcaggacat ggagaagtac 1140
atcctgagag gggatgagac gtttgctgtc ctgagccgcc tggtggccca tgggaaacag 1200
ctgttcctca tcaccaacag tcctttcagc ttcgtagaca aggggatgcg gcacatggtg 1260
ggtcccgatt ggcgccagct cttcgatgtg gtcattgtcc aggcagacaa gcccagcttc 1320
ttcactgacc ggcgcaagcc tttcagaaaa ctcgatgaga agggctcact tcagtgggac 1380
cggatcaccc gcttggaaaa gggcaagatc tatcggcagg gaaacctgtt tgacttctta 1440
cgcttgacgg aatggcgtgg cccccgcgtg ctctacttcg gggaccacct ctatagtgat 1500
ctggcggatc tcatgctgcg gcacggctgg cgcacaggcg ccatcatccc cgagctggag 1560
cgtgagatcc gcatcatcaa cacggagcag tacatgcact cgctgacgtg gcagcaggcg 1620
ctcacggggc tgctggagcg catgcagacc tatcaggacg cggagtcgag gcaggtgctg 1680
gctgcctgga tgaaagagcg gcaggagctg aggtgcatca ccaaggccct gttcaatgcg 1740
cagttcggca gcatcttccg caccttccac aaccccacct acttctcaag gcgcctcgtg 1800
cgcttctctg acctctacat ggcctccctc agctgcctgc tcaactaccg cgtggacttc 1860
accttctacc cacgccgtac gccgctgcag cacgaggcac ccctctggat ggaccagctc 1920
tgcaccggct gcatgaagac ccccttcctt ggtgacatgg cccacatccg ctgagggcac 1980
ttattgtc tgggacaggc cctcagcccc tcctgcccca tccacccaga caagcaataa 2040
aagtggtctc ctccctg 2057
<210>35
<211>2413
<212>DNA
<213>人
<400>35
attcatttcc cccagtgacc ttgacaagtc agaagcttga aagcagggaa atccggatgt 60
tcggttatg aagtggagca gtgagtgtga gcctcaacat agttccagaa ctctccatcc 120
ggactagtta ttgagcatct gcctctcata tcaccagtgg ccatctgagg tgtttccctg 180
gctctgaagg ggtaggcacg atggccaggt gcttcagcct ggtgttgctt ctcacttcca 240
tctggaccac gaggctcctg gtccaaggct ctttgcgtgc agaagagctt tccatccagg 300
tgtcatgcag aattatgggg atcacccttg tgagcaaaaa ggcgaaccag cagctgaatt 360
tcacagaagc taaggaggcc tgtaggctgc tgggactaag tttggccggc aaggaccaag 420
ttgaaacagc cttgaaagct agctttgaaa cttgcagcta tggctgggtt ggagatggat 480
tcgtggtcat ctctaggatt agcccaaacc ccaagtgtgg gaaaaatggg gtgggtgtcc 540
tgatttggaa ggttccagtg agccgacagt ttgcagccta ttgttacaac tcatctgata 600
cttggactaa ctcgtgcatt ccagaaatta tcaccaccaa agatcccata ttcaacactc 660
aaactgcaac acaaacaaca gaatttattg tcagtgacag tacctactcg gtggcatccc 720
cttactctac aatacctgcc cctactacta ctcctcctgc tccagcttcc acttctattc 780
cacggagaaa aaaattgatt tgtgtcacag aagtttttat ggaaactagc accatgtcta 840
cagaaactga accatttgtt gaaaataaag cagcattcaa gaatgaagct gctgggtttg 900
gaggtgtccc cacggctctg ctagtgcttg ctctcctctt ctttggtgct gcagctggtc 960
ttggattttg ctatgtcaaa aggtatgtga aggccttccc ttttacaaac aagaatcagc 1020
agaaggaaat gatcgaaacc aaagtagtaa aggaggagaa ggccaatgat agcaacccta 1080
atgaggaatc aaagaaaact gataaaaacc cagaagagtc caagagtcca agcaaaacta 1140
ccgtgcgatg cctggaagct gaagtttaga tgagacagaa atgaggagac acacctgagg 1200
ggtttctt tcatgctcct taccctgccc cagctgggga aatcaaaagg gccaaagaac 1260
caaagaagaa agtccaccct tggttcctaa ctggaatcag ctcaggactg ccattggact 1320
atggagtgca ccaaagagaa tgcccttctc cttattgtaa ccctgtctgg atcctatcct 1380
cctacctcca aagcttccca cggcctttct agcctggcta tgtcctaata atatcccact 1440
gggagaaagg agttttgcaa agtgcaagga cctaaaacat ctcatcagta tccagtggta 1500
aaaaggcctc ctggctgtct gaggctaggt gggttgaaag ccaaggagtc actgagacca 1560
aggctttctc tactgattcc gcagctcaga ccctttcttc agctctgaaa gagaaacacg 1620
tatcccacct gacatgtcct tctgagcccg gtaagagcaa aagaatggca gaaaagttta 1680
gcccctgaaa gccatggaga ttctcataac ttgagaccta atctctgtaa agctaaaata 1740
aagaaataga acaaggctga ggatacgaca gtacactgtc agcagggact gtaaacacag 1800
cagggtcaa agtgttttct ctgaacacat tgagttggaa tcactgttta gaacacacac 1860
acttactttttctggtctct accactgctg atattttctc taggaaatat acttttacaa 1920
gtaacaaaaa taaaaactct tataaatttc tatttttatc tgagttacag aaatgattac 1980
taaggaagat tactcagtaa tttgtttaaa aagtaataaa attcaacaaa catttgctga 2040
atagctacta tatgtcaagt gctgtgcaag gtattacact ctgtaattga atattattcc 2100
tcaaaaaatt gcacatagta gaacgctatc tgggaagcta tttttttcag ttttgatatt 2160
tctagcttat ctacttccaa actaattttt atttttgctg agactaatct tattcatttt 2220
ctctaatatg gcaaccatta taaccttaat ttattattaa catacctaag aagtacattg 2280
ttacctctat ataccaaagc acattttaaa agtgccatta acaaatgtat cactagccct 2340
cctttttcca acaagaaggg actgagagat gcagaaatat ttgtgacaaa aaattaaagc 2400
atttagaaaa ctt 2413
<210>36
<211>4977
<212>DNA
<213>人
<400>36
gggaggggcg ggatttcctg cgggaggcgc cgagccggcc ttggaaaagg agaaggagaa 60
aggggggcag gggggagtgg gagccaccgt cctgagtgcc agggaccgag cagggccagc 120
gaccccgg cgggcggccg ggagagagcc ctgagaccag tgcaccgctg ctgcctgagg 180
cccaagggaa tgctggctgc tctctgggtg ggcactggtg ttccacagcc aagccgggaa 240
gattggtgtg cccagtccca gcccatcctg gagctgtcgg aagccacaag ctgatatcca 300
tccagatttc catgtagcct tcaccccctc aaagattagc tttccttcgt gtggtggcag 360
ttcacggagc acctttggga gtatccctca gtacctgacg aggagcccac tgcctgggac 420
accagacttg ctcccccgga accgggagcc ctccaagggg ctgtggcatg gcgccctgac 480
gccccagctt ggacccgttg cctgcctttg ccctggactc ctgagtgtag agctcagccc 540
aggagccagt atgggtcgtg aacaggacct gatcctcgcc gtcaagaatg gagatgtgac 600
cggtgtgcag aaactggtgg cgaaggtcaa ggccacaaag acaaagctcc tgggctccac 660
aaagaggctc aacgtgaact accaggatgc tgatggattc tctgccctcc accacgctgc 720
tttggggggc agcctggagc tcatagcctt gctgctagag gctcaggcca ctgttgacat 780
caaggacagc aatggcatgc gcccgctgca ctacgcagcc tggcagggcc ggctggagcc 840
tgtgaggctg ctgctgcgcg cctctgcggc tgtcaatgcc gcctcgctgg acggacagat 900
ccccctgcac ctggctgcac agtatggaca ttatgaggtg tcagaaatgc tcctccagca 960
tcagtccaac ccatgcctgg tcaacaaggc caagaagacg cccctggacc tggcctgtga 1020
atttggccga ctcaaggtgg cccagctgct tctgaacagc cacttatgtg tggcactgct 1080
ggagggtgag gccaaagacc cgtgtgaccc caactacacc acgcccctgc acttggctgc 1140
caagaatggc cacagagaag tcatcaggca gctcctgaga gctgggatcg agatcaaccg 1200
ccagaccaag acgggtacgg cgctccacga ggccgcactg tatggcaaga ccgaggtggt 1260
gcggctgctt ctggagggag gtgtggacgt gaacatccgg aatacgtata accagacggc 1320
gctggacata gtgaatcagt tcaccacctc ccaggccagc cgggaaatca agcagctact 1380
gcgggaggcc tcagggatcc tgaaggtccg agcgctcaag gatttctgga acctccacga 1440
tcccactgct ctcaatgtcc gggcagggga tgtcatcacg gtgctagaac agcatcccga 1500
cggccgctgg aagggccaca tccacgagag ccagaggggc acagaccgca taggctactt 1560
ccccccgggc attgtcgagg tggtcagcaa gcgggtgggc atccctgcag cccgcctccc 1620
ctccgcaccc acccccctgc gcccaggctt ctcccggaca ccgcagcctc ctgccgaaga 1680
acccccgcac cctcttacct acagccagct tcctcgggtg ggcctcagcc cagacagccc 1740
agcaggtgac aggaatagtg tgggcagtga gggcagcgtg ggcagcatcc gcagtgccgg 1800
agcgggcag agctctgagg gcactaatgg ccatggccct ggcctcctga ttgagaacgc 1860
ccagccactg ccctctgctg gagaggacca ggtgctgcca ggactccacc cgccgtccct 1920
ggcagacaac ctgagccacc gccctctggc caactgccgc tctggggagc agatcttcac 1980
ccaggacgtg cggccagaac agctgctgga ggggaaggac gcgcaggcca ttcataactg 2040
gctaagcgag ttccagctgg agggctacac tgcccacttt ctgcaggccg gctatgatgt 2100
gcctaccatc agccgcatga cacctgagga cctgacggcc atcggggtga ccaagcctgg 2160
gcacaggaag aagatcgcct cagagatcgc tcagctcagc atcgccgagt ggctgcccag 2220
ctacatccca acggacctgc tggagtggct gtgtgcactg gggctgccac agtaccacaa 2280
gcagctggtg agcagcggct acgactccat ggggctggtg gccgacctca cctgggagga 2340
gctgcaggag attggggtca acaagctcgg gcatcagaag aagctcatgc tgggggtgaa 2400
gcggctggcg gagcttcggc ggggcctgct gcagggggag gccctcagcg aaggcgggcg 2460
ccggctggcc aagggtccgg agctgatggc catcgaggga ctggagaacg gagaaggccc 2520
agctacagct ggcccacggc tcctcacctt ccagggcagc gaactaagcc cagagctaca 2580
ggcggccatg gcagggggtg gccctgaacc actccccctc ccacctgccc gctctcccag 2640
ccaggagagc atcggggcac gctcacgggg gtctggccac tcacaggaac agcctgcccc 2700
acagcccagc ggtggagatc ccagcccccc ccaggagagg aacctcccag agggcacaga 2760
gcggccccct aagctttgtt cttcacttcc tggccaagga cccccaccct atgtttttat 2820
gtacccccag ggctcaccct ctagcccggc cccagggcca cctcctggcg caccctgggc 2880
cttctcctac ttggccgggc cccctgccac tcccccagac ccgcctcgac ctaagcgccg 2940
gtcccacagc ctaagccgcc ctggccccac agagggggat gctgaggggg aggccgaagg 3000
gccagtgggc agcaccctag gcagttatgc tacccttacc cggcggccag gacgcagtgc 3060
ccttgtccgg accagtccta gcgtgacccc aaccccagct cgggggactc ctcgcagcca 3120
gtcctttgcc ctgcgggccc ggcgcaaagg ccccccgccc ccgcccccca agcgcctcag 3180
ctccgtctct ggccccagcc cggagccacc tccactagat gggagcccag ggcccaagga 3240
aggggccaca gggccccgaa ggcgaacact gagtgaacct gctggcccct cagagccccc 3300
tggcccacct gccccggctg ggcccgcgtc agacacggag gaggaggagc caggccctga 3360
ggggacgccc ccatctcggg gcagctctgg ggaagggctg ccgtttgcag aggaagggaa 3420
cctgaccatc aaacagcgcc cgaagcccgc tggccccccg ccccgagaga cacccgtgcc 3480
ccccggcctc gatttcaacc tcacggaatc agacactgtt aagcggaggc ccaagtgccg 3540
ggagagagag ccactgcaga ccgcactgct ggccttcgga gtggccagtg ccacgcctgg 3600
ccccgctgcc ccactgcctt ccccaactcc tggcgagtct cctccagctt ctagccttcc 3660
ccagcccgag cccagcagcc ttccagccca aggagttcca accccccttg ctcccagccc 3720
cgccatgcag cctccagtgc cgccctgccc agggccaggt ctggaaagct cagcagctag 3780
tcggtggaat ggggagacag aacccccggc cgcccctgct gccctcctca aggtgcccgg 3840
agcaggaaca gcccccaagc ctgtgtcggt ggcctgcacc cagctggcat tttctggccc 3900
taagctagcg ccccggctcg gcccccgccc agtgcctcct ccacggcctg agagcactgg 3960
gactgtgggc ccaggccagg cccagcagag actggagcag accagctcgt ccctggcagc 4020
tgcactgaga gccgcagaga agagcattgg caccaaggag caagagggca cccccagcgc 4080
ctccaccaag cacattctgg atgacatcag caccatgttc gacgccctgg ctgaccagct 4140
ggacgccatg ctggactgag ccctccagca gtgcccactg tgacctgccg aagtccactg 4200
cctttgcccc agcacagaag aggcccctgc caccctaggg acgggccaag ggctggtcag 4260
gctgaagtgc ccctcctagc agggcccctt cccactcagc ccgcggctgt gggcaccaca 4320
gctcttgtgg ggcagcccac cttagaacct gactagcgag ggacctccgc tgcatctcag 4380
caaagcccct cccagggttt gatcgattga gcaggacagc cctgctcctg gacagggacc 4440
ctggtaagag ctctctcctc agggaggaag taggggtggg gctttggggg tgctttctct 4500
gtacccccca gcccatgtcc caagttgtgc caagggaatg cctcttgcca cccaccatcc 4560
tgcccaggcc ctgagaggct ggaggaggcg tgtgtctggc cgggccccct ctccgtaggt 4620
gtacagagga catgtaaata cacagcggtg gtgcccaggc agctcctgcc cccgccttcc 4680
ctcactgagg cagggctagc aggggtggga ggcagtgggg ttaacagatc ccacaagtcc 4740
taacttttca attgtaaatg ttattttcta agcagagaga aatgcatata ttttaaatgg 4800
aatttattct atcaactgcc tgagaggaca caatggggga ggggcttcgg accacagcag 4860
gagccccgac tgcccacctg agggcaggga gagcctgacc ccattggccc aggccctggc 4920
tctgtaacca ttaacctctt cccccaacta acaccaatga aaacaccatt ccacgtg 4977
<210>37
<211>6202
<212>DNA
<213>人
<400>37
cgcagactgt gctggagctg gtgctgaaaa agggggtttg cagaggctgc cctggggctg 60
gtgctgaaag aagagcccac agctgacttc atggtgctac aataacctca gaatctactt 120
ttcactctca ggagaaccca cagtctaata tttagacatg atggcaaact gggcggaagc 180
aagacctctc ctcattctta ttgttttatt agggcaattt gtctcaataa aagcccagga 240
agaagacgag gatgaaggat atggtgaaga aatagcctgc actcagaatg gccagatgta 300
cttaaacagg gacatttgga aacctgcccc ttgtcagatc tgtgtctgtg acaatggagc 360
cattctctgt gacaagatag aatgccagga tgtgctggac tgtgccgacc ctgtaacgcc 420
ccctggggaa tgctgtcctg tctgttcaca aacacctgga ggtggcaata caaattttgg 480
agaggaaga aagggacaaa agggagaacc aggattagtg cctgttgtaa caggcatacg 540
tggtcgtcca ggaccggcag gacctccagg atcacaggga ccaagaggag agcgagggcc 600
aaaaggaaga cctggccctc gtggacctca gggaattgat ggagaaccag gtgttcctgg 660
tcaacctggt gctccaggac ctcctggaca tccgtcccac ccaggacccg atggcttgag 720
caggccgttt tcagctcaaa tggctgggtt ggatgaaaaa tctggacttg ggagtcaagt 780
aggactaatg cctggctctg tgggtcctgt tggcccaagg ggaccacagg gtttacaagg 840
acagcaaggt ggtgcaggac ctacaggacc tcctggtgaa cctggtgatc ctggaccaat 900
gggtccgatt ggttcacgtg gaccagaggg ccctcctggt aaacctgggg aagatggtga 960
acctggcaga aatggaaatc ctggtgaagt gggatttgca ggatctccgg gagctcgtgg 1020
atttcctggg gctcctggtc ttccaggtct gaagggtcac cgaggacaca aaggtcttga 1080
aggccctaaa ggtgaagttg gagcacctgg ttccaagggt gaagctggcc ccactggtcc 1140
aatgggtgcc atgggtcctc tgggtccgag gggaatgcca ggagagagag ggagacttgg 1200
gccacagggt gctcctggac aacgaggtgc acatggtatg cctggaaaac ctggaccaat 1260
gggtcctctt gggataccag gctcttctgg ttttccagga aatcctggaa tgaagggaga 1320
agcaggtcct acaggggcgc gaggccctga aggtcctcag gggcagagag gtgaaactgg 1380
gcccccaggt ccagttggct ctccaggtct tcctggtgca ataggaactg atggtactcc 1440
tggtcccaaa ggcccaacgg gctctccggg tacctctggt cctcctggct cagcagggcc 1500
tcctggatct ccaggacctc agggtagcac tggtcctcag gggaattcgg gccttccggg 1560
tgatccaggt ttcaaaggag aagctggccc aaaaggggaa ccagggccac atggtattca 1620
gggtccgata ggcccacccg gtgaagaagg caaaagaggt cccagaggtg acccaggaac 1680
acttggtcct ccagggccag tgggagaaag gggtgctcct ggcaatcgtg gttttccagg 1740
ctctgatggt ttacctgggc caaagggtgc tcaaggagaa cggggtcctg taggttcttc 1800
aggacccaaa ggaagccagg gggatccagg acgtccaggg gaacctgggc ttccaggtgc 1860
tcggggtttg acaggaaatc ctggtgttca aggtcctgaa ggaaaacttg gacctttggg 1920
tgcgccaggg gaagatggcc gtccaggtcc tccaggctcc ataggaatca aagggcagcc 1980
cgggaccatg ggccttccag gccccaaagg tagcaatggt gaccctggga aacctggaga 2040
agcaggaaat cctggagttc ctgggcaaag gggagctcct ggaaaagatg gtaaagttgg 2100
tccttatggt cctcctgggc cgccgggtct acgtggtgaa agaggagaac aaggacctcc 2160
gggcccaca ggttttcagg ggcatcctgg tcctccaggt cctcctggag aaggtggaaa 2220
accaggtgat caaggtgttc ctggaggtcc cggagcagtt ggcccgttag gacctagagg 2280
agaacgagga aatcctgggg aaagaggaga acctgggata actggactcc ctggtgagaa 2340
gggaatggct ggaggacatg gtcctgatgg cccaaaaggc agtccaggtc catctgggac 2400
ccctggagat acaggcccac caggtcttca aggtatgccg ggagaaagag gaattgcagg 2460
aactcctggc cccaagggtg acagaggtgg cataggagaa aaaggtgctg aaggcacagc 2520
tggaaatgat ggtgcaggag gtcttccagg tcctttgggc cctccaggtc cggcaggcct 2580
actgggagaa aagggtgaac ctggtcctcg aggtttagtt ggtcctcctg gctcccgggg 2640
caatcctggt tctcgaggtg aaaatgggcc aactggagct gttggttttg ccggacccca 2700
ggggtctgac ggacagcctg gagtaaaagg tgaacctgga gagccaggac agaagggaga 2760
tgctggttct cctggaccac aaggtttagc aggatcccct ggccctcatg gtcctaatgg 2820
tgttcctgga ctaaaaggtg gtcgaggaac ccaaggtccg cctggtgcta caggatttcc 2880
tggttctgcg ggcagagttg gacctccagg ccctgctgga gctccaggac ctgcgggacc 2940
cctaggggaa cccgggaagg agggacctcc aggtcctcgt ggggaccctg gctctcatgg 3000
gcgtgtggga gtccgaggac cagctggccc ccctggtggc ccaggagaca aaggggaccc 3060
aggagaagat gggcaacctg gtccagatgg cccccctggt ccagctggaa cgaccgggca 3120
gagaggaatt gttggcatgc ctgggcaacg tggagagaga ggcatgcccg gcctaccagg 3180
cccagcggga acaccaggaa aagtaggacc aactggtgca acaggagata aaggtccacc 3240
tggacctgtg gggcccccag gctccaatgg tcctgtaggg gaacctggac cagaaggtcc 3300
ctggcaat gatggtaccc caggacggga tggtgctgtt ggagaacgtg gtgatcgtgg 3360
agaccctggg cctgcaggtc tgccaggctc tcagggtgcc cctggaactc ctggccctgt 3420
gggtgctcca ggagatgcag gacaaagagg agatccgggt tctcggggtc ctataggaca 3480
cctgggtcga gctggaaaac gtggattacc tggaccccaa ggacctcgtg gtgacaaagg 3540
tgatcatgga gaccgaggcg acagaggtca gaagggccac agaggcttta ctggtcttca 3600
gggtcttcct ggccctcctg gtccaaatgg tgaacaagga agtgctggaa tccctggacc 3660
atttggccca agaggtcctc caggcccagt tggtccttca ggtaaagaag gaaaccctgg 3720
gccacttggg ccattgggac ctccaggtgt acgaggcagt gtaggagaag caggacctga 3780
gggccctcct ggtgagcctg gcccacctgg ccctccgggt ccccctggcc accttacagc 3840
tgctcttggg gatatcatgg ggcactatga tgaaagcatg ccagatccac ttcctgagtt 3900
tactgaagat caggcggctc ctgatgacaa aaacaaaacg gacccagggg ttcatgctac 3960
cctgaagtca ctcagtagtc agattgaaac catgcgcagc cccgatggct cgaaaaagca 4020
cccagcccgc acgtgtgatg acctaaagct ttgccattcc gcaaagcaga gtggtgaata 4080
ctggattgat cctaaccaag gatctgttga agatgccatc aaagtttact gcaacatgga 4140
aacaggagaa acatgtattt cagcaaaccc atccagtgta ccacgtaaaa cctggtgggc 4200
cagtaaatct cctgacaata aacctgtttg gtatggtctt gatatgaaca gagggtctca 4260
gttcgcttat ggagaccacc aatcacctaa tacagccatt actcagatga cttttttgcg 4320
ccttttatca aaagaagcct cccagaacat cacttacatc tgtaaaaaca gtgtaggata 4380
catggacgat caagctaaga acctcaaaaa agctgtggtt ctcaaagggg caaatgactt 4440
agatatcaaa gcagagggaa atattagatt ccggtatatc gttcttcaag acacttgctc 4500
taagcggaat ggaaatgtgg gcaagactgt ctttgaatat agaacacaga atgtggcacg 4560
cttgcccatc atagatcttg ctcctgtgga tgttggcggc acagaccagg aattcggcgt 4620
tgaaattggg ccagtttgtt ttgtgtaaag taagccaaga cacatcgaca atgagcacca 4680
ccatcaatga ccaccgccat tcacaagaac tttgactgtt tgaagttgat cctgagactc 4740
ttgaagtaat ggctgatcct gcatcagcat tgtatatatg gtcttaagtg cctggcctcc 4800
ttatccttca gaatatttat tttacttaca atcctcaagt tttaattgat tttaaatatt 4860
tttcaataca acagtttagg tttaagatga ccaatgacaa tgaccacctt tgcagaaagt 4920
aaactgattg aataaataaa tctccgtttt cttcaattta tttcagtgta atgaaaaagt 4980
tgcttagtat ttatgaggaa attcttcttc ctggcaggta gcttaaagag tggggtatat 5040
gagccacaa cacatgttta ttttgcttgg ctgcagttga aaaatagaaa ttagtgccct 5100
tttgtgacct ctcattccaa gattgtcaat taaaaatgag tttaaaatgt ttaacttgtg 5160
atcgagacct acatgcatgt cttgatattg tgtaactata atagagactc tttaaggaga 5220
atcttaaaaa aaaaaaacgt ttctcactgt cttaaataga atttttaaat agtatatatt 5280
cagtggcatt ttggagaaca aagtgaattt acttcgactt cttaaatttt tgtaaaagac 5340
tataagttta gacatctttc tcattcaaat ttaaagatat ctttctcctc ttgatcaatc 5400
tatcaatatt gatagaagtc acactagtat ataccattta atacatttac actttcttat 5460
ttaagaagat attgaatgca aaataattga catatagaac tttacaaaca tatgtccaag 5520
gactctaaat tgagactctt ccacatgtac aatctcatca tcctgaagcc tataatgaag 5580
aaaaagatct agaaactgag ttgtggagct gactctaatc aaatgtgatg attggaatta 5640
gaccatttgg cctttgaact ttcataggaa aaatgaccca acatttctta gcatgagcta 5700
cctcatctct agaagctggg atggacttac tattcttgtt tatattttag atactgaaag 5760
gtgctatgct tctgttatta ttccaagact ggagataggc agggctaaaa aggtattatt 5820
atttttcctt taatgatggt gctaaaattc ttcctataaa attccttaaa aataaagatg 5880
gtttaatcac taccattgtg aaaacataac tgttagactt cccgtttctg aaagaaagag 5940
catcgttcca atgcttgttc actgttcctc tgtcatactg tatctggaat gctttgtaat 6000
acttgcatgc ttcttagacc agaacatgta ggtccccttg tgtctcaata cttttttttt 6060
cttaattgca tttgttggct ctattttaat ttttttcttt taaaataaac agctgggacc 6120
atcccaaaag acaagccatg catacaactt tggtcatgta tctctgcaaa gcatcaaatt 6180
aaatgcacgc ttttgtcatg tc 6202
<210>38
<211>3085
<212>DNA
<213>人
<400>38
gacggccgcc ggagccgcga ggccaactgt cgcctggttg ggcccggaaa tgggacgtcg 60
cgctttctca gggagcgtag aagcagccag ggcctctcca agccgctgct gtgacagaaa 120
gtgagtgagc tgccggagga tgtccaccgc cacgacagtc gcccccgcgg ggatcccggc 180
gaccccgggc cctgtgaacc cacccccccc ggaggtctcc aaccccagca agcccggccg 240
caagaccaac cagctgcagt acatgcagaa tgtggtggtg aagacgctct ggaaacacca 300
gttcgcctgg cccttctacc agcccgtgga cgcaatcaaa ttgaacctgc cggattatca 360
taaaataatt aaaaacccaa tggatatggg gactattaag aagagactag aaaataatta 420
ttattggagt gcaagcgaat gtatgcagga cttcaacacc atgtttacaa attgttacat 480
ttataacaag cccacagatg acatagtgct aatggcccaa gctttagaga aaatttttct 540
acaaaaagtg gcccagatgc cccaagagga agttgaatta ttaccccctg ctccaaaggg 600
caaaggtcgg aagccggctg cgggagccca gagcgcaggt acacagcaag tggcggccgt 660
gtcctctgtc tccccagcga ccccctttca gagcgtgccc cccaccgtct cccagacgcc 720
cgtcatcgct gccacccctg taccaaccat cactgcaaac gtcacgtcgg tcccagtccc 780
cccagctgcc gccccacctc ctcctgccac acccatcgtc cccgtggtcc ctcctacgcc 840
gcctgtcgtc aagaaaaagg gcgtgaagcg gaaagcagac acaaccactc ccacgacgtc 900
ggccatcact gccagccgga gtgagtcgcc cccgccgttg tcagacccca agcaggccaa 960
agtggtggcc cggcgggaga gtggtggccg ccccatcaag cctcccaaga aggacctgga 1020
ggacggcgag gtgccccagc acgcaggcaa gaagggcaag ctgtcggagc acctgcgcta 1080
ctgcgacagc atcctcaggg agatgctatc caagaagcac gcggcctacg cctggccctt 1140
ctacaagcca gtggatgccg aggccctgga gctgcacgac taccacgaca tcatcaagca 1200
cccgatggac ctcagcaccg tgaaaaggaa gatggatggc cgagagtacc cagacgcaca 1260
gggctttgct gctgatgtcc ggctgatgtt ctcgaattgc tacaaataca atcccccaga 1320
ccacgaggtt gtggccatgg cccggaagct ccaggacgtg tttgagatga ggtttgccaa 1380
gatgccagat gagcccgtgg aggcaccggc gctgcctgcc cccgcggccc ccatggtgag 1440
caagggcgct gagagcagcc gtagcagtga ggagagctct tcggactcag gcagctcgga 1500
ctcggaggag gagcgggcca ccaggctggc ggagctgcag gagcagctga aggccgtgca 1560
cgagcagctg gccgccctgt ctcaggcccc agtaaacaaa ccaaagaaga agaaggagaa 1620
gaaggagaag gagaagaaga agaaggacaa ggagaaggag aaggagaagc acaaagtgaa 1680
ggccgaggaa gagaagaagg ccaaggtggc tccgcctgcc aagcaggctc agcagaagaa 1740
ggctcctgcc aagaaggcca acagcacgac cacggccggc agacagctga agaaaggcgg 1800
caagcaggca tctgcctcct acgactcaga ggaagaggag gagggcctgc ccatgagcta 1860
atgaaaag cgccagctta gcctggacat caaccggctg cccggggaga agctgggccg 1920
ggtagtgcac atcatccaat ctcgggagcc ctcgctcagg gactccaacc ccgacgagat 1980
agaaattgac tttgagactc tgaaacccac cactttgcgg gaactggaga gatatgtcaa 2040
gtcttgttta cagaaaaagc aaaggaaacc gttctcagca agcgggaaga aacaggcagc 2100
caagtcgaaa gaggagctag ctcaggaaaa gaagaaggag ctggaaaagc gtctgcagga 2160
tgtcagcggg cagctgagca gcagcaagaa gcccgcccgg aaagagaagc ccggctcagc 2220
accctcaggg ggcccgtcca ggctcagcag cagcagctcc tccgagtctg ggagcagcag 2280
ctccagcggg tccagctctg acagcagtga ctcagaatga actggcttcg gacagaacag 2340
gacagatgga tgtcgcacac gccgagactc tgccgtaccc ctctgtggtt catattacta 2400
ttctgttcc atggtgtgca ggtctgcttc ttaattcagt gttatgatat cttccagttt 2460
ttgctttcat aggtcagaga tctatcttgt gtgtgcgtta gacttgatga gaaggtgtga 2520
actctgcaga aagtctcttc ttcatcactg aattcagtca cttggagatg acaacttcaa 2580
atgctaaccc gatgacccca gaaaaccgtg tgagattcgt accgaagaac cttgtggaat 2640
ccctttgctt aggcccaacc tggtcgatag ctcgagaaag aattttttcc aaggaaatgt 2700
ctcggatatg ggtactgtat ttgaaagctg ttagctttgt caacacgcat tgtccttgtc 2760
atttgggccc cgagctctga ccctcgtgtc tgacgcggcc acctctttct ggaggggctg 2820
aggacagatg tgcctgcttg tggagaccag gctgggccta agcgaagggt catcgcagcc 2880
ccagcccgga gcgtggagcc cttggggggt ggtcgggtgg gatgtgcgtt ctccgctcgt 2940
ggtgatgtca ggagctcctc ggagggaaca gagcggctgt gtatgcagcc tgcaggtttc 3000
catacactga agcttttacc tcaactttaa aaaaaaaaaa gaagaaaaga ttaaaaaaaa 3060
aaaaaaaaaa ctcgaggcat ctatg 3085
<210>39
<211>3120
<212>DNA
<213>人
<400>39
gagcaagccg agtggaggga ggcaaaggcc aggctgagga tcagggtggc ccgggtggca 60
gcggggaggc gctgcatgct ggaggctgtg ctgagtgccc ggtgcaggtg agccggtcct 120
gcggagttgt gccgagtgcc tgctgcagtc tcatttccag ttcctccatg acgtggcaag 180
tgaagacagg aatgaaagga atgtaaagca gcttttctct gaagagaaga agagagagag 240
acacagccaa gaccgaggct gggccaagat ggcgtctgtg tttcgaagcg aggagatgtg 300
tttgtcacaa ctgtttctcc aggtggaagc tgcatattgc tgtgtggctg agctcggaga 360
gctcggattg gttcagttca aagatttaaa tatgaatgtg aacagctttc aaaggaaatt 420
tgtgaatgaa gtcagaaggt gtgaatcact ggagagaatc ctccgttttc tggaagacga 480
gatgcaaaat gagattgtag ttcagttgct cgagaaaagc ccactgaccc cgctcccacg 540
ggaaatgatt accctggaga ctgttctaga aaaactggaa ggagagttac aggaagccaa 600
ccagaaccag caggccttga aacaaagctt cctagaactg acagaactga aatacctcct 660
agaaaacc caagacttct ttgagacgga aaccaattta gctgatgatt tctttactga 720
ggacacttct ggcctcctgg agttgaaagc agtgcctgca tatatgaccg gaaagttggg 780
gttcatagcc ggtgtgatca acagggagag gatggcttcc tttgagcggt tactgtggcg 840
aatctgccga ggaaacgtgt acttgaagtt cagtgagatg gacgcccctc tggaggatcc 900
tgtgacgaaa gaagaaattc agaagaacat attcatcata ttttaccaag gagagcagct 960
caggcagaaa atcaagaaga tctgtgatgg gtttcgagcc actgtctacc cttgcccaga 1020
gcctgcggtg gagcgcagag agatgttgga gagcgtcaat gtgaggctgg aagatttaat 1080
caccgtcata acacaaacag agtctcaccg ccagcgcctg ctgcaggaag ccgctgccaa 1140
ctggcactcc tggctcatca aggtgcagaa gatgaaagct gtctaccaca tcctgaacat 1200
gtgcaacatc gacgtcaccc agcagtgtgt catcgccgag atctggttcc cggtggcaga 1260
tgccacacgt atcaagaggg cactggagca aggcatggaa ctaagtggct cctccatggc 1320
ccccatcatg accacagtgc aatctaaaac agcccctccc acatttaaca ggaccaataa 1380
attcacagct ggcttccaga atattgttga tgcctatggt gtcggcagct accgggagat 1440
aaacccagcc ccctacacca tcatcacttt ccccttcctg ttcgctgtga tgtttggaga 1500
ctgtggtcat ggaaccgtga tgctcctggc tgcactttgg atgattctga atgagagacg 1560
cttgctctcc cagaagacag acaatgagat ttggaacacc ttcttccacg ggcgctatct 1620
gatcctactt atgggcatct tctccatcta cacgggtttg atctacaatg actgcttctc 1680
caagtccttg aacatctttg gctcttcttg gagtgtccaa cccatgttca gaaacggcac 1740
atggaatact catgtaatgg aggaaagtct atatctgcag ctggacccag ccataccagg 1800
gtgtatttt ggaaatccat acccgtttgg gattgatccg atttggaact tggcttcaaa 1860
caaactcaca tttctgaact cgtataaaat gaagatgtcg gtgatcctgg gaattgtcca 1920
gatggttttt ggtgtcatcc tcagcctttt caatcacata tacttcagaa gaactctcaa 1980
catcattctg caatttatcc ctgagatgat ttttatcctg tgtctgtttg gatacctggt 2040
tttcatgatc attttcaaat ggtgctgctt tgacgtccac gtatctcagc acgcccccag 2100
catcctcatc cacttcatca acatgtttct gtttaactac agtgactctt ccaacgcacc 2160
cctctacaaa catcagcaag aagtccaaag tttctttgtg gttatggctt tgatttctgt 2220
gccgtggatg cttctgatta agccgtttat tcttagagcc agtcatcgga aatcccagct 2280
gcaggcatcc aggatccaag aagatgccac tgagaacatt gaaggtgata gctccagccc 2340
tctagccgt tctggccaga ggacttctgc agatacccac ggggctctgg acgaccatgg 2400
agaagagttc aactttggag acgtctttgt ccaccaagcc atccacacca tcgagtactg 2460
cctgggctgc atttcaaaca cagcctccta cctgcggctc tgggccctca gcctggctca 2520
tgcacaactg tctgaagtgc tctggactat ggtgatgaac agcggccttc agacgcgagg 2580
ctggggagga atcgtcgggg tttttattat ttttgccgta tttgctgtcc tgacagtagc 2640
catccttctg atcatggagg gcctctctgc tttcctgcac gccctgcgac tgcactgggt 2700
tgagttccag aacaagttct atgtcgggga tggttacaag ttttctccat tctcctttaa 2760
acacatcctg gatggcacag ccgaggagta ggctgagggc tgcacctccc acggtggtca 2820
ccatgccaat gaaggaagtt cagtcttgtc tttgatatca gcccctgcaa ggcgctcaat 2880
gggaaggttg ttcttggctc acctgaagca tgaaactgtg tattatttgg acgtcagcct 2940
gtggatttga tacgacttaa ccacgtcaga ggaaggactt tggcaagtga tattgtcttc 3000
atgtggggta ttaattctca aataataaag taattgacaa atgaggggag aatgctaaac 3060
agatgtcttc ttgcaatatt ttaaatattg tatttgagaa aataaacatc tgagtcattc 3120
<210>40
<211>2538
<212>DNA
<213>人
<400>40
ccctcggggc tgcccctgct gcctgtgctg ttcgctcttg gggggcttct gctcctctcc 60
aatgcctcct gtgtcggggg ggtcctctgg cagcggagac tcaggcgtct tgctgaggca 120
ctcaacttcc ccccacacct tcatcctgga aggtcggaag aggaccgagt caggaacgaa 180
tatgaggaga gccagtggac aggagagcgg gacactcaga gctccacggt cagcacaaca 240
gaggcagagc cgtattaccg ctccctgagg gacttcagcc cccagctgcc cccgacgcag 300
gaggaggtgt cttattcccg aggtttcaca ggtgaagatg aggatatggc cttccctggg 360
cacttgtatg atgaggtaga aagaacgtac cccccgtctg gagcctgggg acccctctac 420
gatgaagtgc agatgggacc ctgggacctc cactggcctg aagacacata tcaggatcca 480
agaggaatct atgaccaggt ggccggagac ttggacactc tggaacccga ttctctgccc 540
ttcgagctga ggggacatct ggtatggggt ttcaaccatg ttagccaggc tggtctcaaa 600
ctcctggcct caagtgatcc acccgcctca gcctcccaaa gtgctgagat tacagagtct 660
cactctgtag tccaggttgg agtgcagtgg cgttatttcg gctcactgca tcctctgcct 720
cctggttcaa gagattctct tgcctcagcc tcccgcatag ctgggattac agcaccttgg 780
gaggcagagg tgagcagatc acctcagggc actcaggatt ccccagtgac caggtctggt 840
cccccctcca ggggctggca gtccctgagc tttgatggcg gggccttcca ccttaagggc 900
acaggagagc tgacacgggc cttgctggtt ctccggctgt gtgcctggcc cccactcgtc 960
actcacgggc tgttgctcca ggcctggtct cggcgactcc tgggctcccg gctctcaggc 1020
gcatttctcc gagcatccgt ctatgggcag tttgtggctg gtgagacagc agaggaggtg 1080
aagggctgcg tgcagcagct gcggaccctc agcctccgac cactgctggc agtgcccact 1140
gaggaggagc cggactctgc tgccaagagg atgaggcttc accatgttgg ccaggctggt 1200
cttgaactcc tgaccccagc ggcatctggc tctgttgccc aggctggagt gcagtggaga 1260
caatcctctg acaggggagg aggaaaccag gctgctgcct ccaggtcttc ccttctccag 1320
gaggcagcat tctccccacc atgcggaagg ttgcagcttc cagcccaacc tgcctccaga 1380
cacggtgcta ggggccgagg aagcatgaag gcaaaatccc tgacctcgag gcacttactt 1440
gcaagtcagg ggcaagagac aataattaaa accaaagtca gaatcccagc actttggaag 1500
gctgagcctg ggcaacacag caagaccccg tctcagcaaa acaaaagtca gtacgtaaca 1560
acactttggg aggccgatgt gggcagatca cttgagaacc tccaggtctc ctgcctcaat 1620
gctgagcaga accagcacct ccgggcctcc ctcagccgcc tgcatcgggt ggcacaggta 1680
acccctcctg ctggaaccag cacctccggg cctccctctg ccgcctgcat tgggtggcac 1740
agccgcctgc atcgggtggc acagtatgcc cgggcccagc acgtgcggct cctggtggat 1800
gcggagtaca cctcactgaa ccctgcgctc tcgctgctgg tggctgccct ggctgtgcgc 1860
tggaacagcc cgggtgaagg cgggccctgg gtgtggaaca cctaccaggc ctgtctaaag 1920
gacacattcg agcggctggg gagggatgca gaggctgcgc acagggccgg cctggccttc 1980
ggagtgaagc tggtacgagg tgcatatctg gacaaggaga gagcggtggc ccagctccat 2040
gggatggaag accccactca gcctgactat gaggccacca gtgagctgaa cagagcatct 2100
cccttcagtt acagccgctg cctggaactg atgctgacgc acgtggcccg ccatggcccc 2160
atgtgccacc tcatggtggc ttcccacaat gaggaatctg ttcgccaggc aaccaagcgc 2220
atgtgggagc tgggcattcc tctggatggg actgtctgtt tcggacaact tctgggcatg 2280
tgtgaccacg tctctctagc actggggcag gccggctatg tagtgtataa gtccattccc 2340
tatggctcct tggaggaggt aatcccctac ctgatccgga gggcccagga gaaccggagc 2400
gtgcttcagg gtgcccgcag ggaacaggag ctgctcagcc aagaactgtg gcggcggctg 2460
ctgccaggat gccgaaggat accccactag cacccctgag ggggtcatgt ggtcaataaa 2520
agtccttagg tgctgcct 2538
<210>41
<211>4737
<212>DNA
<213>人
<400>41
gccccgggaa gcgcagccat ggctctgcgg aggctggggg ccgcgctgct gctgctgccg 60
ctgctcgccg ccgtggaaga aacgctaatg gactccacta cagcgactgc tgagctgggc 120
tggatggtgc atcctccatc agggtgggaa gaggtgagtg gctacgatga gaacatgaac 180
acgatccgca cgtaccaggt gtgcaacgtg tttgagtcaa gccagaacaa ctggctacgg 240
accaagttta tccggcgccg tggcgcccac cgcatccacg tggagatgaa gttttcggtg 300
cgtggctgca gcagcatccc cagcgtgcct ggctcctgca aggagacctt caacctctat 360
tactatgagg ctgactttga ctcggccacc aagaccttcc ccaactggat ggagaatcca 420
tgggtgaagg tggataccat tgcagccgac gagagcttct cccaggtgga cctgggtggc 480
ggcgtcatga aaatcaacac cgaggtgcgg agcttcggac ctgtgtcccg cagcggcttc 540
tacctggcct tccaggacta tggcggctgc atgtccctca tcgccgtgcg tgtcttctac 600
cgcaagtgcc cccgcatcat ccagaatggc gccatcttcc aggaaaccct gtcgggggct 660
gagagcacat cgctggtggc tgcccggggc agctgcatcg ccaatgcgga agaggtggat 720
gtacccatca agctctactg taacggggac ggcgagtggc tggtgcccat cgggcgctgc 780
atgtgcaaag caggcttcga ggccgttgag aatggcaccg tctgccgagg ttgtccatct 840
gggactttca aggccaacca aggggatgag gcctgtaccc actgtcccat caacagccgg 900
accacttctg aaggggccac caactgtgtc tgccgcaatg gctactacag agcagacctg 960
gaccccctgg acatgccctg cacaaccatc ccctccgcgc cccaggctgt gatttccagt 1020
gtcaatgaga cctccctcat gctggagtgg acccctcccc gcgactccgg aggccgagag 1080
gacctcgtct acaacatcat ctgcaagagc tgtggctcgg gccggggtgc ctgcacccgc 1140
tgcggggaca atgtacagta cgcaccacgc cagctaggcc tgaccgagcc acgcatttac 1200
atcagtgacc tgctggccca cacccagtac accttcgaga tccaggctgt gaacggcgtt 1260
actgaccaga gccccttctc gcctcagttc gcctctgtga acatcaccac caaccaggca 1320
gctccatcgg cagtgtccat catgcatcag gtgagccgca ccgtggacag cattaccctg 1380
tcgtggtccc agccggacca gcccaatggc gtgatcctgg actatgagct gcagtactat 1440
gagaaggagc tcagtgagta caacgccaca gccataaaaa gccccaccaa cacggtcacc 1500
gtgcagggcc tcaaagccgg cgccatctat gtcttccagg tgcgggcacg caccgtggca 1560
ggctacgggc gctacagcgg caagatgtac ttccagacca tgacagaagc cgagtaccag 1620
acaagcatcc aggagaagtt gccactcatc atcggctcct cggccgctgg cctggtcttc 1680
ctcattgctg tggttgtcat cgccatcgtg tgtaacagaa gacgggggtt tgagcgtgct 1740
gactcggagt acacggacaa gctgcaacac tacaccagtg gccacatgac cccaggcatg 1800
aagatctaca tcgatccttt cacctacgag gaccccaacg aggcagtgcg ggagtttgcc 1860
aaggaaattg acatctcctg tgtcaaaatt gagcaggtga tcggagcagg ggagtttggc 1920
gaggtctgca gtggccacct gaagctgcca ggcaagagag agatctttgt ggccatcaag 1980
acgctcaagt cgggctacac ggagaagcag cgccgggact tcctgagcga agcctccatc 2040
atgggccagt tcgaccatcc caacgtcatc cacctggagg gtgtcgtgac caagagcaca 2100
cctgtgatga tcatcaccga gttcatggag aatggctccc tggactcctt tctccggcaa 2160
aacgatgggc agttcacagt catccagctg gtgggcatgc ttcggggcat cgcagctggc 2220
gtgaagtacc tggcagacat gaactatgtt caccgtgacc tggctgcccg caacatcctc 2280
gtcaacagca acctggtctg caaggtgtcg gactttgggc tctcacgctt tctagaggac 2340
gatacctcag accccaccta caccagtgcc ctgggcggaa agatccccat ccgctggaca 2400
gccccggaag ccatccagta ccggaagttc acctcggcca gtgatgtgtg gagctacggc 2460
attgtcatgt gggaggtgat gtcctatggg gagcggccct actgggacat gaccaaccag 2520
gatgtaatca atgccattga gcaggactat cggctgccac cgcccatgga ctgcccgagc 2580
gccctgcacc aactcatgct ggactgttgg cagaaggacc gcaaccaccg gcccaagttc 2640
ggccaaattg tcaacacgct agacaagatg atccgcaatc ccaacagcct caaagccatg 2700
gcgcccctct cctctggcat caacctgccg ctgctggacc gcacgatccc cgactacacc 2760
agctttaaca cggtggacga gtggctggag gccatcaaga tggggcagta caaggagagc 2820
ttcgccaatg ccggcttcac ctcctttgac gtcgtgtctc agatgatgat ggaggacatt 2880
ctccgggttg gggtcacttt ggctggccac cagaaaaaaa tcctgaacag tatccaggtg 2940
atgcgggcgc agatgaacca gattcagtct gtggaggttt gacattcacc tgcctcggct 3000
cacctcttcc tccaagcccc gccccctctg ccccacgtgc cggccctcct ggtgctctat 3060
ccactgcagg gccagccact cgccaggagg ccacgggcca cgggaagaac caagcggtgc 3120
cagccacgag acgtcaccaa gaaaacatgc aactcaaacg acggaaaaaa aaagggaatg 3180
ggaaaaaaga aaacagatcc tgggaggggg cgggaaatac aaggaatatt ttttaaagag 3240
gattctcata aggaaagcaa tgactgttct tgcgggggat aaaaaagggc ttgggagatt 3300
catgcgatgt gtccaatcgg agacaaaagc agtttctctc caactccctc tgggaaggtg 3360
acctggccag agccaagaaa cactttcaga aaaacaaatg tgaaggggag agacaggggc 3420
cgcccttggc tcctgtccct gctgctcctc taggcctcac tcaacaacca agcgcctgga 3480
ggacgggaca gatggacaga cagccaccct gagaacccct ctgggaaaat ctattcctgc 3540
caccactggg caaacagaag aatttttctg tctttggaga gtattttaga aactccaatg 3600
aaagacactg tttctcctgt tggctcacag ggctgaaagg ggcttttgtc ctcctgggtc 3660
agggagaacg cggggacccc agaaaggtca gccttcctga ggatgggcaa cccccaggtc 3720
tgcagctcca ggtacatatc acgcgcacag cctggcagcc tggccctcct ggtgcccact 3780
cccgccagcc cctgcctcga ggactgatac tgcagtgact gccgtcagct ccgactgccg 3840
ctgagaaggg ttgatcctgc atctgggttt gtttacagca attcctggac tcgggggtat 3900
tttggtcaca gggtggtttt ggtttagggg gtttgtttgt tgggttgttt tttgtttttt 3960
ggtttttttt aatgacaatg aagtgacact ttgacatttc ctaccttttg aggacttgat 4020
ccttctccag gaagaaggtg ctttctgctt actgacttag gcaatacacc aagggcgaga 4080
ttttatatgc acatttctgg atttttttat acggttttca ttgacactct tccctcctcc 4140
cacctgccac caggcctcac caaagcccac tgccatgggg ccatctgggc cattcagaga 4200
ctggagtgag atttgggtgt ggagggggag gcgccaaggt ggaggagctt cccactccag 4260
gactgttgat gaaagggaca gattgaggag gaagtgggct ctgaggctgc agggctggaa 4320
gtccttgccc acttcccact ctcctgcccc aatctatcta gtacttccca ggcaaatagg 4380
cccctttgag gctcctgagt gccctcagat ggtcaaaacc cagttttccc tctgggagcc 4440
taaaccaggc tgcatcggag gccaggaccc ggatcattca ctgtgatacc ctgccctcca 4500
gagggtgcgc tcagagacac gggcaagcat gcctcttccc ttccctggag agaaagtgtg 4560
tgatttctct cccacctcct tccccccacc agacctttgc tgggcctaaa ggtcttggcc 4620
atggggacgc cctcagtcta gggatctggc cacagactcc ctcctgtgaa ccaacacaga 4680
cacccaagca gagcaatcag ttagtgaatt gaatggaaat aaacgcttta gttataa 4737
<210>42
<211>1505
<212>DNA
<213>人
<400>42
agctgcggcg ctgggctggc ggcggcgagt ccacgtgctc cccgcggccg gttgaaaccg 60
ttggcgggcg ctggctgaga ggcaatgttt gctgtcttcc attggagtga ctgaatttct 120
acatgacggc tttttgacaa gacttaaaac ctgtcttgga tagagaatat ttagccattt 180
acctaaaaat ggtatttttt acatgcaatg catgtggtga atcagtgaag aaaatacaag 240
tggaaaagca tgtgtctgtt tgcagaaact gtgaatgcct ttcttgcatt gactgcggta 300
aagatttctg gggcgatgac tataaaaacc acgtgaaatg cataagtgaa gatcagaagt 360
atggtggcaa aggctatgaa ggtaaaaccc acaaaggcga catcaaacag caggcgtgga 420
ttcagaaaat tagtgaatta ataaagagac ccaatgtcag ccccaaagtg agagaacttt 480
tagagcaaat tagtgctttt gacaacgttc ccaggaaaaa ggcaaaattt cagaattgga 540
tgaagaacag tttaaaagtt cataatgaat ccattctgga ccaggtgtgg aatatctttt 600
ctgaagcttc caacagcgaa ccagtcaata aggaacagga tcaacggcca ctccacccag 660
tggcaaatcc acatgcagaa atctccacca aggttccagc ctccaaagtg aaagacgccg 720
tggaacagca aggggaggtg aagaagaata aaagagaaag aaaggaagaa cggcagaaga 780
aaaggaaaag agaaaagaaa gaactaaagt tagaaaacca ccaggaaaac tcaaggaatc 840
agaagcctaa gaagcgcaaa aagggacagg aggctgacct tgaggctggt ggggaggaag 900
tccctgaggc caatggctct gcagggaaga ggagcaagaa gaagaagcag cgcaaggaca 960
gcgccagtga ggaagaggca cgcgtgggcg cagggaagag gaagcggagg cactcggaag 1020
ttgaaacaga ttctaagaag aaaaagatga agctcccaga gcatcctgag ggcggagaac 1080
cagaagacga tgaggctcct gcaaaaggta aattcaactg gaagggaact attaaagcaa 1140
ttctgaaaca ggccccagac aatgaaataa ccatcaaaaa gctaaggaaa aaggttttag 1200
ctcagtacta cacagtgaca gatgagcatc acagatccga agaggaactc ctggtcatct 1260
ttaacaagaa aatcagcaag aaccctacct ttaagttatt aaaggacaaa gtcaagcttg 1320
tgaaatgaac atttgtgtat ttaaaaattg aatccattct gctgacttct tcctttcact 1380
gctgtttata aaatgtgtaa tgaattctaa caactcaaat tttgcttttt gaagctgtat 1440
ttttaagtta agaaaatata tttttggtat aacttttatg agaaaaataa aatatattct 1500
ggtcc 1505
<210>43
<211>557
<212>DNA
<213>人
<400>43
cctcctggga gggagctgaa gccgctcgca agactcccgt agtccccacc tctctcagct 60
tccggctggt agtagttccg cttcctgtcc gactgtggtg tctttgctga gggtcacatt 120
gagctgcagg ttgaatccgg ggtgccttta ggattcagca ccatggcgga agacatggag 180
accaaaatca agaactacaa gaccgcccct tttgacagcc gcttccccaa ccagaaccag 240
actagaaact gctggcagaa ctacctggac ttccaccgct gtcagaaggc aatgaccgct 300
aaaggaggcg atatctctgt gtgcgaatgg taccagcgtg tgtaccagtc cctctgcccc 360
acatcctggg tcacagactg ggatgagcaa cgggctgaag gcacgtttcc cgggaagatc 420
tgaactggct gcatctccct ttcctctgtc ctccatcctt ctcccaggat ggtgaagggg 480
gacctggtac ccagtgatcc ccaccccagg atcctaaatc atgacttacc tgctaataaa 540
aactcattgg aaaagtg 557
<210>44
<211>662
<212>DNA
<213>人
<400>44
ggggggggga gcacaaagtt gggagtgaca ccagagcctc ctgcaagatg cttctgattc 60
tgctgtcagt ggccctgctg gccttcagct cagctcagga tttaaatgaa gatgtcagcc 120
aggaagatgt tcccctcgta atatcagatg gaggagactc tgagcagttc atagatgagg 180
agcgtcaggg accacctttg ggaggacagc aatctcaacc ctctgctggt gatgggaacc 240
aggatgatgg ccctcagcag ggaccacccc aacaaggagg ccagcagcaa caaggtccac 300
cacctcctca gggaaagcca caaggaccac cccaacaggg aggccatccc cctcctcctc 360
aaggaaggcc acaaggacca ccccaacagg gaggccatcc ccgtcctcct cgaggaaggc 420
cacaaggacc accccaacag ggaggccatc agcaaggtcc tcccccacct cctcctggaa 480
agccccaggg accacctccc caagggggcc gcccacaagg acctccacag gggcagtctc 540
ctcagtaatc caggattcaa tgacaggaag tgaataagaa gataacagtg tttcaaatgc 600
cgtgaaacat ggcatcatgc tctaacttca gtataccaat aaaacaatca gcttgcaatt 660
tc 662
<210>45
<211>2232
<212>DNA
<213>人
<400>45
tttccccttc tctgccctgc tccaggcacc aggctctttc cccttcagtg tctcagagga 60
ggggacggca gcaccatgga cccccgcttg tccactgtcc gccagacctg ctgctgcttc 120
aatgtccgca tcgcaaccac cgccctggcc atctaccatg tgatcatgag cgtcttgttg 180
ttcatcgagc actcagtaga ggtggcccat ggcaaggcgt cctgcaagct ctcccagatg 240
ggctacctca ggatcgctga cctgatctcc agcttcctgc tcatcaccat gctcttcatc 300
atcagcctga gcctactgat cggcgtagtc aagaaccggg agaagtacct gctgcccttc 360
ctgtccctgc aaatcatgga ctatctcctg tgcctgctca ccctgctggg ctcctacatt 420
gagctgcccg cctacctcaa gttggcctcc cggagccgtg ctagctcctc caagttcccc 480
ctgatgacgc tgcagctgct ggacttctgc ctgagcatcc tgaccctctg cagctcctac 540
atggaagtgc ccacctatct caacttcaag tccatgaacc acatgaatta cctccccagc 600
caggaggata tgcctcataa ccagttcatc aagatgatga tcatcttttc catcgccttc 660
atcactgtcc ttatcttcaa ggtctacatg ttcaagtgcg tgtggcggtg ctacagattg 720
atcaagtgca tgaactcggt ggaggagaag agaaactcca agatgctcca gaaggtggtc 780
ctgccgtcct acgaggaagc cctgtctttg ccatcgaaga ccccagaggg gggcccagca 840
ccacccccat actcagaggt gtgaccctcg ccaggcccca gccccagtgc tgggaggggt 900
ggagctgcct cataatctgc ttttttgctt tggtggcccc tgtggcctgg gtgggccctc 960
ccgcccctcc ctggcaggac aatctgcttg tgtctccctc gctggcctgc tcctcctgca 1020
gggcctgtga gctgctcaca actgggtcaa cgctttaggc tgagtcactc ctcgggtctc 1080
tccataattc agcccaacaa tgcttggttt atttcaatca gctctgacac ttgtttagac 1140
gattggccat tctaaagttg gtgagtttgt caagcaacta tcgacttgat cagttcagcc 1200
aagcaactga caaatcaaaa acccacttgt cagttcagta aaataatttg gtcaaacaac 1260
agtctattgc attgatttat aaatagttgt cagttcacat agcaatttaa tcaagtaatc 1320
attaattagt taccccctat atataaatat atgtaatcaa tttcttcaaa tagcttgctt 1380
acatgataat caattagcca accatgagtc atttagaata gtgataaata gaatacacag 1440
aatagtgatg aaattcaatt taaaaaatca cgttagcctc caaaccattt aattcaaatg 1500
aacccatcaa ctggatgcca actctggcga atgtaggacc tctgagtggc tgtataattg 1560
ttaattcaaa tgaaattcat ttaaacagtt gacaaactgt cattcaacaa ttagctccag 1620
gaaataacag ttatttcatc ataaaacagt cccttcaaac acacaattgt tctgctgaag 1680
agttgtcatc aacaatccaa tgctcaccta ttcagttgct ctgtggtcag tgtggctgca 1740
tagcagtgga ttccatgaaa ggagtcattt tagtgatgag ctgccagtcc attcccaggc 1800
caggctgtcg ctggccatcc attcagtcga ttcagtcata ggcgaatctg ttctgcccga 1860
ggcttgtggt caagcaaaaa ttcagccctg aaatcaggca catctgttcg ttggactaaa 1920
cccacaggtt agttcagtca aagcaggcaa cccccttgtg ggcactgacc ctgccactgg 1980
ggtcatggcg gttgtggcag ctggggaggt ttggccccaa cagccctcct gtgcctgctt 2040
ccctgtgtgt cggggtcctc cagggagctg acccagaggt ggaggccacg gaggcagggt 2100
ctctggggac tgtcgggggg tacagaggga gaaggctctg caagagctcc ctggcaatac 2160
ccccttgtgt aattgctttg tgtgcgacag ggaggaagtt tcaataaagc aacaacaagc 2220
ttcaaggaat tc 2232
<210>46
<211>3136
<212>DNA
<213>人
<400>46
gaagcgcccg ccccggccgg agccgccatg taaccggcgc cgcccggagc ccgagccgcg 60
cgggccccag cgacccgccc gccatggggg acgaggacga cgatgagagc tgcgccgtgg 120
agctgcggat cacagaagcc aacctgaccg ggcacgagga gaaggtgagc gtggagaact 180
tcgagctgct caaggtgctg ggcacgggag cctacggcaa ggtgttcctg gtgcggaagg 240
cgggcgggca cgacgcgggg aagctgtacg ccatgaaggt gctgcgcaag gcggcgctgg 300
tgcagcgcgc caagacgcaa gagcacacgc gcaccgagcg ctcggtgctg gagctggtgc 360
gccaggcgcc cttcctggtc acgctgcact acgctttcca gacggatgcc aagctgcacc 420
tcatcctgga ctatgtgagc ggcggggaga tgttcaccca cctctaccag cgccagtact 480
tcaaggaggc tgaggtgcgc gtgtatgggg gtgagatcgt gctggccctg gaacacctgc 540
acaagctcgg catcatttac cgagacctga aactggagaa tgtgctgctg gactccgagg 600
gccacattgt cctcacggac ttcgggctga gcaaggagtt cctgacggag gagaaagagc 660
ggaccttctc cttctgtggc accatcgagt acatggcccc cgaaatcatc cgtagcaaga 720
cggggcatgg caaggctgtg gactggtgga gcctgggcat cttgctcttc gagctgctga 780
gggggcctc gcccttcacc ctggagggcg agaggaacac gcaggctgag gtgtctcgac 840
ggatcctgaa gtgctcccct cccttccccc ctcggatcgg gcccgtggcg caggacctgc 900
tgcagcggct gctttgtaag gatcctaaga agcgattggg cgcggggccc cagggggcac 960
aagaagtccg gaaccatccc ttcttccagg gcctcgattg ggtggctctg gctgccagga 1020
agattccagc cccattccgg ccccaaatcc gctcagagct ggatgtgggc aactttgcgg 1080
aggaattcac tcggctggag cctgtctact caccccctgg cagcccccca cctggggacc 1140
cccgaatctt tcagggatac tcctttgtgg caccctccat tctctttgac cacaacaacg 1200
cggtgatgac cgatgggctg gaagcgcctg gtgctggaga ccggccaggt cgggcagcgg 1260
tggccaggag cgctatgatg caggactcgc ccttcttcca gcagtacgag ctggacctgc 1320
gggagcctgc gctgggccag ggcagctttt ctgtgtgtcg ccgctgccgc cagcgccaga 1380
gcggccagga gttcgcagtc aagatcctca gtcgcaggct ggaggcgaac acgcagcgcg 1440
aagtggctgc cctgcgcctg tgccagtcac accccaacgt ggtgaatctg cacgaggtgc 1500
atcacgacca gctgcacacg tacctggtcc tggagctgct gcggggcggg gagctgctgg 1560
agcacatccg caagaagcgg cacttcagcg agtcggaagc aagccagatc ctgcgcagcc 1620
tcgtgtcggc cgtgagcttc atgcacgagg aggcgggcgt ggtgcaccgc gacctcaagc 1680
cggagaacat cctgtacgcc gacgacacgc ccggggcccc ggtgaaaatc atcgacttcg 1740
ggttcgcgcg gttgcggccg cagagtcccg gggtgcccat gcagacgccc tgcttcacgc 1800
tgcagtacgc tgcccccgag ctgctggcgc agcagggcta cgacgagtcc tgcgacctct 1860
ggagcctggg cgtcattctg tacatgatgc tgtcggggca ggtccccttc cagggggcct 1920
ctggccaggg cgggcagagc caggcggccg agatcatgtg caaaatccgc gaggggcgct 1980
tctcccttga cggggaggcc tggcagggtg tatccgagga agccaaggag ctggtccgag 2040
ggctcctgac cgtggacccc gccaagcggc tgaagctcga gggactgcgg ggcagctcgt 2100
ggctgcagga cggcagcgcg cgctcctcgc ccccgctccg gacgcccgac gtgctcgagt 2160
cctctgggcc cgcagtgcgc tcgggtctca acgccacctt catggcattc aaccggggca 2220
agcgggaggg cttcttcctg aagagcgtgg agaatgcacc cctggccaag cggcggaagc 2280
agaagctgcg gagcgccacc gcctcccgcc ggggctcccc tgcaccagcc aacccgggcc 2340
gagcccccgt cgcctccaaa ggggcccccc gccgagccaa cggccccctg cccccctcct 2400
aatccccacc actgtgaccc ccttccctca taggggctgt gacctgggag cccggctcac 2460
tcccggaggc ctctgcctgc ggctgacctg atccccaagg gactgtcctt tcctctccta 2520
ccccacccca ctcccagaca gagcagaagt atttttataa gcagagaatt ttttatgtct 2580
taccagatag agttgcaggg aagggggggc ctgctgggga gtggggtttg gggggccctc 2640
tcccaggaca ctgcctcttc tgggcagaag gcccctccag ggggactgct ccaacaggaa 2700
agagcccctc ccccacttct aagcactgag ttaggagtgc taactcctaa actgggaccc 2760
cctaccctgt tctcccctga ggccccgttc ctgggagggg cacccctcaa ctgtcacttt 2820
atggactgtc tgtgcaatta cgtccaccaa agacccgtgt tgggggtact gaaggagagg 2880
ccctggggga ccctctgaag catttctgcc tcactttatg tcatctgctt ctcccctgtt 2940
ggggctaagg aaggagatag gtggctccta aaagaggagg ccatcttctc acccacccct 3000
tcctctttgg cacagctact cctggctggg ggtggggcct tgggggtctg ggctgggcat 3060
ccatggtcac tgcctcagcc cagccaggct gtgcctttga ctttaaaata aaagtccacc 3120
cagtgctgtg tgtggc 3136
<210>47
<211>6918
<212>DNA
<213>人
<400>47
ctttgacctg cagtagagcc tacgtcagag gctggcgcaa acagaagtgc agcggtggcg 60
gcggctggtt gcgggccggc ggcgggctgg cggagatgga ggatcttgtt caagatgggg 120
tggcttcacc agctacccct gggaccggga aatctaagct ggaaacattg cccaaagaag 180
acctcatcaa gtttgccaag aaacagatga tgctaataca gaaagctaaa tcaaggtgta 240
cagaattgga gaaagaaatt gaagaactca gatcaaaacc tgttactgaa ggaactggtg 300
atattattaa ggcattaact gaacgtctgg atgctcttct tctggaaaaa gcagagactg 360
agcaacagtg tctttctctg aaaaaggaaa atataaaaat gaagcaagag gttgaggatt 420
ctgtaacaaa gatgggagat gcacataagg agttggaaca atcacatata aactatgtga 480
aagaaattga aaatttgaaa aatgagttga tggcagtacg ttccaaatac agtgaagaca 540
aagctaactt acaaaagcag ctggaagaag caatgaatac gcaattagaa ctttcagaac 600
aacttaaatt tcagaacaac tctgaagata atgttaaaaa actacaagaa gagattgaga 660
aaattaggcc aggctttgag gagcaaattt tatatctgca aaagcaatta gacgctacca 720
ctgatgaaaa gaaggaaaca gttactcaac tccaaaatat cattgaggct aattctcagc 780
attaccaaaa aaatattaat agtttgcagg aagagctttt acagttgaaa gctatacacc 840
aagaagaggt gaaagagttg atgtgccaga ttgaagcatc agctaaggaa catgaagcag 900
agataaataa gttgaacgag ctaaaagaga acttagtaaa acaatgtgag gcaagtgaaa 960
agaacatcca gaagaaatat gaatgtgagt tagaaaattt aaggaaagcc acctcaaatg 1020
caaaccaaga caatcagata tgttctattc tcttgcaaga aaatacattt gtagaacaag 1080
tagtaaatga aaaagtcaaa cacttagaag ataccttaaa agaacttgaa tctcaacaca 1140
gtatcttaaa agatgaggta acttatatga ataatcttaa gttaaaactt gaaatggatg 1200
ctcaacatat aaaggatgag ttttttcatg aacgggaaga cttagagttt aaaattaatg 1260
aattattact agctaaagaa gaacagggct gtgtaattga aaaattaaaa tctgagctag 1320
caggtttaaa taaacagttt tgctatactg tagaacagca taacagagaa gtacagagtc 1380
ttaaggaaca acatcaaaaa gaaatatcag aactaaatga gacatttttg tcagattcag 1440
aaaaagaaaa attaacatta atgtttgaaa tacagggtct taaggaacag tgtgaaaacc 1500
tacagcaaga aaagcaagaa gcaattttaa attatgagag tttacgagag attatggaaa 1560
ttttacaaac agaactgggg gaatctgctg gaaaaataag tcaagagttc gaatcaatga 1620
agcaacagca agcatctgat gttcatgaac tgcagcagaa gctcagaact gcttttactg 1680
aaaaagatgc ccttctcgaa actgtgaatc gcctccaggg agaaaatgaa aagttactat 1740
ctcaacaaga attggtacca gaacttgaaa ataccataaa gaaccttcaa gaaaagaatg 1800
gagtatactt acttagtctc agtcaaagag ataccatgtt aaaagaatta gaaggaaaga 1860
taaattctct tactgaggaa aaagatgatt ttataaataa actgaaaaat tcccatgaag 1920
aaatggataa tttccataag aaatgtgaaa gggaagaaag attgattctt gaacttggga 1980
agaaagtaga gcaaacaatc cagtacaaca gtgaactaga acaaaaggta aatgaattaa 2040
caggaggact agaggagact ttaaaagaaa aggatcaaaa tgaccaaaaa ctagaaaaac 2100
ttatggttca aatgaaagtt ctctctgaag acaaagaagt attgtcagct gaagtgaagt 2160
ctctttatga ggaaaacaat aaactcagtt cagaaaaaaa acagttgagt agggatttgg 2220
aggttttttt gtctcaaaaa gaagatgtta tccttaaaga acatattact caattagaaa 2280
agaaacttca gttaatggtt gaagagcaag ataatttaaa taaactgctt gaaaatgagc 2340
aagttcagaa gttatttgtt aaaactcagt tgtatggttt tcttaaagaa atgggatcag 2400
aagtttcaga agacagtgaa gagaaagatg ttgttaatgt cctacaggca gtcggtgaat 2460
ccttggcaaa aataaatgag gaaaaatgca acctggcttt tcagcgtgat gaaaaagtat 2520
tagagttaga aaaagagatt aagtgccttc aagaagagag tgtagttcag tgtgaagaac 2580
ttaagtcttt attgagagac tatgagcaag agaaagttct cttaaggaaa gagttagaag 2640
aaatacagtc agaaaaagag gccctgcagt ctgatcttct agaaatgaag aatgctaatg 2700
aaaaaacaag gcttgaaaat cagaatcttt taattcaagt tgaagaagta tctcaaacat 2760
gtagcaaaag tgaaatccat aatgaaaaag aaaaatgttt tataaaggaa catgaaaacc 2820
taaagccact actagaacaa aaagaattac gagataggag agcagagttg atactattaa 2880
aggattcctt agcaaaatca ccttctgtaa aaaatgatcc tctgtcttca gtaaaagagt 2940
tggaagaaaa aatagaaaat ctggaaaaag aatgcaaaga aaaggaggag aaaataaata 3000
agataaaatt agttgccgta aaggcaaaga aagaactaga ttccagcaga aaagagaccc 3060
agactgtgaa ggaagaactt gaatctcttc gatcagaaaa ggaccagtta tctgcttcca 3120
tgagagatct cattcaagga gcagaaagct ataagaatct tttattagaa tatgaaaagc 3180
agtcagagca actggatgtg gaaaaagaac gtgctaataa ttttgagcat cgtattgaag 3240
accttacaag acaattaaga aattcgactt tgcagtgtga aacaataaat tctgataatg 3300
aagatctcct ggctcgtatt gagacattac agtctaatgc caaattatta gaagtacaga 3360
ttttagaagt ccagagagcc aaagcaatgg tagacaaaga attagaagct gaaaaacttc 3420
agaaagaaca gaagataaag gaacatgcca ctactgtaaa tgaacttgaa gaacttcagg 3480
tacaacttca aaaggaaaag aaacagcttc agaaaaccat gcaagaatta gagctggtta 3540
aaaaggatgc ccaacaaacc acattgatga atatggaaat agctgattat gaacgtttga 3600
tgaaagaact aaatcaaaag ttaactaata aaaacaacaa gatagaagat ttggagcaag 3660
aaataaaaat tcaaaaacag aaacaagaaa ccctacaaga agaaataact tcattacagt 3720
cttcagtaca acaatatgaa gaaaaaaaca ccaaaatcaa gcaattgctt gtgaaaacca 3780
aaaaggaact ggcagattca aagcaagcag aaactgatca cttaatactt caagcatctt 3840
taaaaggtga gctggaggca agccagcagc aagtagaagt ctataaaata cagctggctg 3900
aaataacatc agagaagcac aaaatccacg agcacctgaa aacctctgcg gaacagcacc 3960
agcgtacgct aagtgcatac cagcagagag tgacagcact acaggaagag tgccgtgctg 4020
ccaaggcaga acaagctact gtaacctctg aattcgagag ctacaaagtc cgagttcata 4080
ttgttctaaa acaacagaaa aataaatcta tgtctcaggc tgaaactgag ggcgctaaac 4140
aagaaaggga acatctggaa atgctgattg accagctaaa aatcaaatta caagatagcc 4200
aaaataactt acagattaat gtatctgaac ttcaaacatt gcagtctgaa catgatacac 4260
tgctagaaag gcacaacaag atgctgcagg aaactgtgtc caaagaggcg gaactccggg 4320
aaaaattgtg ttcaatacag tcagagaaca tgatgatgaa atctgaacat acacagactg 4380
tgagtcagct aacatcccag aacgaggtcc ttcgaaatag cttccgagat caagtgcgac 4440
atttgcagga agaacacaga aagacagtgg agacattaca gcagcagctc tccaagatgg 4500
aagcacagct cttccagctt aagaatgaac cgaccacaag aagcccagtt tcctctcaac 4560
aatctttgaa gaaccttcga gaaaggagaa acacagacct cccgcttcta gacatgcaca 4620
ctgtaacccg ggaagaggga gaaggcatgg agacaactga tacggagtct gtgtcttccg 4680
ccagcacata cacacagtct ttagagcagc tgcttaactc tcccgaaact aaacttgagc 4740
ctccattatg gcatgctgaa tttaccaaag aagaattggt tcagaagctc agttccacca 4800
caaaaagtgc agatcactta aacggcctgc ttcgggaaac agaagcaacc aatgcaattc 4860
ttatggagca aattaagctt ctcaaaagtg aaataagaag attggaaagg aatcaagagc 4920
gagagaagtc tgcagctaac ctggaatact tgaagaacgt cttgctgcag ttcattttct 4980
tgaaaccagg tagtgaaaga gagagacttc ttcctgttat aaatacgatg ttgcagctca 5040
gccctgaaga aaagggaaaa cttgctgcgg ttgctcaagg tgaggaagaa aatgcttccc 5100
gttcttctgg atgggcatcc tatcttcata gttggtctgg acttcgatag gttgatggaa 5160
ggaatatttt tattaaccaa atagaatcta tttacaaaaa tggttcacgt atattaccac 5220
aattcttttg tcaaaaagtg tgtatatatg tttgcatcta catatatttg tacatctata 5280
tgacagatgt attttaaaag tttcatcttg aagtaaaagt acaacagctt gaagtgttga 5340
tagcaggcca cagccctcta actcatgtga tttcccatgc atgctgccag aataaaacca 5400
ccaggaatga attcactccc cacttctctg gaacctcagg acccgcccat ttctcggcag 5460
tactgtgaat tttgaagtta aactaaattt tggtaccata ccaactggaa tttaggcttt 5520
aaaaataatg tttcaaggcc aggtgtggtg attcatgcct gaaatcccac tactttggga 5580
ggctgaggct ggagaattgc ttgaggctag tgagctgtga ctcccactgc actccagctc 5640
ggggaacaga gcgagacctt gtctctaaaa ataatagtaa taaaataaaa ataacgtttt 5700
atgactattt attgcaaggt cagagttaca gattgttata aattgttgag aaatttttgt 5760
gattagaata tgaaggaaaa agctttgttg gtaaaagtga catgttaagg ggctatgaag 5820
taaatatgct gcagttaatt atgctaagtt aaaatacagt ttagttattt gctttaaaat 5880
aaactcttct ttttttcttt aaagtatact atctcaaaac tcattatgtt gtcagagccc 5940
tagagctggc tagtgtaaca ctgactatga gtaggtgggc ccacacttga gttgaggtga 6000
tttcatggtg tctttccagg ctcttgatag ggtgtcactg catgcaagcc atgaatctgt 6060
tttgagaatc ctctccattt tcccaaataa aaacctatca caacagtgac tatatcactc 6120
agcattggat ctaaatataa aagtggtgct ttcagtgttt ttggcagata gtgttccata 6180
agctttccat cagaagggat tttagacacc ttagaggtcc gtgctacatc gtcacagttc 6240
ctccgaataa ccttaggtgg tagtgttact tgcctttgac acctctgcat atgttttaat 6300
gactagatcc aaactgtgtt gttcttaaat caaaaattgg ataatttgta atatttatgt 6360
gttaatcaca cagtatgctc tctgaagttc tcttaagcct tcagtttata ctcttaattt 6420
aattttcttt ctgagctgga gaactggctt tgcactttgg ttacacagaa cattggtttc 6480
caattcagtt taactgaaat ttgctgctga tatgttgagt ttgttcttta aaaaatagct 6540
catatatctc atctttcctc ctgtcttaga agaacagacc taactagtga atgtattaat 6600
gaaaatgcat ctatttcaga gctgacatga agagtttagt ttttttactt tataaactgt 6660
gaatatgagt atgccagctg catacgatgt aactaatcat atttaaatat atttcacttt 6720
ctctttgact ttagaccttt tgaagtctgt ataaacttgt tttgaaatat agtctctgct 6780
tacgaatgtc ataacaaaat aattttttgc atgataaaaa attactttga ttacaaaagg 6840
catattcttt catggtttct gcaatgagag gaagtgtaat gattatttta atatttctat 6900
taaatatgtt taactgta 6918
<210>48
<211>6773
<212>DNA
<213>人
<400>48
cggccccaga aaacccgagc gagtaggggg cggcgcgcag gagggaggag aactgggggc 60
gcgggaggct ggtgggtgtc gggggtggag atgtagaaga tgtgacgccg cggcccggcg 120
ggtgccagat tagcggacgc gctgcccgcg gttgcaacgg gatcccgggc gctgcagctt 180
gggaggcggc tctccccagg cggcgtccgc ggagacaccc atccgtgaac cccaggtccc 240
gggccgccgg ctcgccgcgc accaggggcc ggcggacaga agagcggccg agcggctcga 300
ggctggggga ccgcgggcgc ggccgcgcgc tgccgggcgg gaggctgggg ggccggggcc 360
ggggccgtgc cccggagcgg gtcggaggcc ggggccgggg ccgggggacg gcggctcccc 420
gcgcggctcc agcggctcgg ggatcccggc cgggccccgc agggaccatg gcagccggga 480
gcatcaccac gctgcccgcc ttgcccgagg atggcggcag cggcgccttc ccgcccggcc 540
acttcaagga ccccaagcgg ctgtactgca aaaacggggg cttcttcctg cgcatccacc 600
ccgacggccg agttgacggg gtccgggaga agagcgaccc tcacatcaag ctacaacttc 660
aagcagaaga gagaggagtt gtgtctatca aaggagtgtg tgctaaccgt tacctggcta 720
tgaaggaaga tggaagatta ctggcttcta aatgtgttac ggatgagtgt ttcttttttg 780
aacgattgga atctaataac tacaatactt accggtcaag gaaatacacc agttggtatg 840
tggcactgaa acgaactggg cagtataaac ttggatccaa aacaggacct gggcagaaag 900
ctatactttt tcttccaatg tctgctaaga gctgatttta atggccacat ctaatctcat 960
ttcacatgaa agaagaagta tattttagaa atttgttaat gagagtaaaa gaaaataaat 1020
gtgtatagct cagtttggat aattggtcaa acaatttttt atccagtagt aaaatatgta 1080
accattgtcc cagtaaagaa aaataacaaa agttgtaaaa tgtatattct cccttttata 1140
ttgcatctgc tgttacccag tgaagcttac ctagagcaat gatctttttc acgcatttgc 1200
tttattcgaa aagaggcttt taaaatgtgc atgtttagaa acaaaatttc ttcatggaaa 1260
tcatatacat tagaaaatca cagtcagatg tttaatcaat ccaaaatgtc cactatttct 1320
tatgtcattc gttagtctac atgtttctaa acatataaat gtgaatttaa tcaattcctt 1380
tcatagtttt ataattctct ggcagttcct tatgatagag tttataaaac agtcctgtgt 1440
aaactgctgg aagttcttcc acagtcaggt caattttgtc aaacccttct ctgtacccat 1500
acagcagcag cctagcaact ctgctggtga tgggagttgt attttcagtc ttcgccaggt 1560
cattgagatc catccactca catcttaagc attcttcctg gcaaaaattt atggtgaatg 1620
aatatggctt taggcggcag atgatataca tatctgactt cccaaaagct ccaggatttg 1680
tgtgctgttg ccgaatactc aggacggacc tgaattctga ttttatacca gtctcttcaa 1740
aaacttctcg aaccgctgtg tctcctacgt aaaaaaagag atgtacaaat caataataat 1800
tacactttta gaaactgtat catcaaagat tttcagttaa agtagcatta tgtaaaggct 1860
caaaacatta ccctaacaaa gtaaagtttt caatacaaat tctttgcctt gtggatatca 1920
agaaatccca aaatattttc ttaccactgt aaattcaaga agcttttgaa atgctgaata 1980
tttctttggc tgctacttgg aggcttatct acctgtacat ttttggggtc agctcttttt 2040
aacttcttgc tgctcttttt cccaaaaggt aaaaatatag attgaaaagt taaaacattt 2100
tgcatggctg cagttccttt gtttcttgag ataagattcc aaagaactta gattcatttc 2160
ttcaacaccg aaatgctgga ggtgtttgat cagttttcaa gaaacttgga atataaataa 2220
ttttataatt caacaaaggt tttcacattt tataaggttg atttttcaat taaatgcaaa 2280
tttgtgtggc aggattttta ttgccattaa catatttttg tggctgcttt ttctacacat 2340
ccagatggtc cctctaactg ggctttctct aattttgtga tgttctgtca ttgtctccca 2400
aagtatttag gagaagccct ttaaaaagct gccttcctct accactttgc tggaaagctt 2460
cacaattgtc acagacaaag atttttgttc caatactcgt tttgcctcta tttttcttgt 2520
ttgtcaaata gtaaatgata tttgcccttg cagtaattct actggtgaaa aacatgcaaa 2580
gaagaggaag tcacagaaac atgtctcaat tcccatgtgc tgtgactgta gactgtctta 2640
ccatagactg tcttacccat cccctggata tgctcttgtt ttttccctct aatagctatg 2700
gaaagatgca tagaaagagt ataatgtttt aaaacataag gcattcatct gccatttttc 2760
aattacatgc tgacttccct tacaattgag atttgcccat aggttaaaca tggttagaaa 2820
caactgaaag cataaaagaa aaatctaggc cgggtgcagt ggctcatgcc tatattccct 2880
gcactttggg aggccaaagc aggaggatcg cttgagccca ggagttcaag accaacctgg 2940
tgaaaccccg tctctacaaa aaaacacaaa aaatagccag gcatggtggc gtgtacatgt 3000
ggtctcagat acttgggagg ctgaggtggg agggttgatc acttgaggct gagaggtcaa 3060
ggttgcagtg agccataatc gtgccactgc agtccagcct aggcaacaga gtgagacttt 3120
gtctcaaaaa aagagaaatt ttccttaata agaaaagtaa tttttactct gatgtgcaat 3180
acatttgtta ttaaatttat tatttaagat ggtagcacta gtcttaaatt gtataaaata 3240
tcccctaaca tgtttaaatg tccattttta ttcattatgc tttgaaaaat aattatgggg 3300
aaatacatgt ttgttattaa atttattatt aaagatagta gcactagtct taaatttgat 3360
ataacatctc ctaacttgtt taaatgtcca tttttattct ttatgcttga aaataaatta 3420
tggggatcct atttagctct tagtaccact aatcaaaagt tcggcatgta gctcatgatc 3480
tatgctgttt ctatgtcgtg gaagcaccgg atgggggtag tgagcaaatc tgccctgctc 3540
agcagtcacc atagcagctg actgaaaatc agcactgcct gagtagtttt gatcagttta 3600
cttgaatca ctaactgact gaaaattgaa tgggcaaata agtgcttttg tctccagagt 3660
atgcgggaga cccttccacc tcaagatgga tatttcttcc ccaaggattt caagatgaat 3720
tgaaattttt aatcaagata gtgtgcttta ttctgttgta ttttttatta ttttaatata 3780
ctgtaagcca aactgaaata acatttgctg ttttataggt ttgaagaaca taggaaaaac 3840
taagaggttt tgtttttatt tttgctgatg aagagatatg tttaaatatg ttgtattgtt 3900
ttgtttagtt acaggacaat aatgaaatgg agtttatatt tgttatttct attttgttat 3960
atttaataat agaattagat tgaaataaaa tataatggga aataatctgc agaatgtggg 4020
tttcctggtg tttcctctga ctctagtgca ctgatgatct ctgataaggc tcagctgctt 4080
tatagttctc tggctaatgc agcagatact cttcctgcca gtggtaatac gattttttaa 4140
gaaggcagtt tgtcaatttt aatcttgtgg atacctttat actcttaggg tattatttta 4200
tacaaaagcc ttgaggattg cattctattt tctatatgac cctcttgata tttaaaaaac 4260
actatggata acaattcttc atttacctag tattatgaaa gaatgaagga gttcaaacaa 4320
atgtgtttcc cagttaacta gggtttactg tttgagccaa tataaatgtt taactgtttg 4380
tgatggcagt attcctaaag tacattgcat gttttcctaa atacagagtt taaataattt 4440
cagtaattct tagatgattc agcttcatca ttaagaatat cttttgtttt atgttgagtt 4500
agaaatgcct tcatatagac atagtctttc agacctctac tgtcagtttt catttctagc 4560
tgctttcagg gttttatgaa ttttcaggca aagctttaat ttatactaag cttaggaagt 4620
atggctaatg ccaacggcag tttttttctt cttaattcca catgactgag gcatatatga 4680
tctctgggta ggtgagttgt tgtgacaacc acaagcactt tttttttttt taaagaaaaa 4740
aaggtagtga atttttaatc atctggactt taagaaggat tctggagtat acttaggcct 4800
gaaattatat atatttggct tggaaatgtg tttttcttca attacatcta caagtaagta 4860
cagctgaaat tcagaggacc cataagagtt cacatgaaaa aaatcaattc atttgaaaag 4920
gcaagatgca ggagagagga agccttgcaa acctgcagac tgctttttgc ccaatataga 4980
ttgggtaagg ctgcaaaaca taagcttaat tagctcacat gctctgctct cacgtggcac 5040
cagtggatag tgtgagagaa ttaggctgta gaacaaatgg ccttctcttt cagcattcac 5100
accactacaa aatcatcttt tatatcaaca gaagaataag cataaactaa gcaaaaggtc 5160
aataagtacc tgaaaccaag attggctaga gatatatctt aatgcaatcc attttctgat 5220
ggattgttac gagttggcta tataatgtat gtatggtatt ttgatttgtg taaaagtttt 5280
aaaaatcaag ctttaagtac atggacattt ttaaataaaa tatttaaaga caatttagaa 5340
aattgcctta atatcattgt tggctaaata gaatagggga catgcatatt aaggaaaagg 5400
tcatggagaa ataatattgg tatcaaacaa atacattgat ttgtcatgat acacattgaa 5460
tttgatccaa tagtttaagg aataggtagg aaaatttggt ttctattttt cgatttcctg 5520
taaatcagtg acataaataa ttcttagctt attttatatt tccttgtctt aaatactgag 5580
ctcagtaagt tgtgttaggg gattatttct cagttgagac tttcttatat gacattttac 5640
tatgttttga cttcctgact attaaaaata aatagtagaa acaattttca taaagtgaag 5700
aattatataa tcactgcttt ataactgact ttattatatt tatttcaaag ttcatttaaa 5760
ggctactatt catcctctgt gatggaatgg tcaggaattt gttttctcat agtttaattc 5820
caacaacaat attagtcgta tccaaaataa cctttaatgc taaactttac tgatgtatat 5880
ccaaagcttc tccttttcag acagattaat ccagaagcag tcataaacag aagaataggt 5940
ggtatgttcc taatgatatt atttctacta atggaataaa ctgtaatatt agaaattatg 6000
ctgctaatta tatcagctct gaggtaattt ctgaaatgtt cagactcagt cggaacaaat 6060
tggaaaattt aaatttttat tcttagctat aaagcaagaa agtaaacaca ttaatttcct 6120
caacattttt aagccaatta aaaatataaa agatacacac caatatcttc ttcaggctct 6180
gacaggcctc ctggaaactt ccacatattt ttcaactgca gtataaagtc agaaaataaa 6240
gttaacataa ctttcactaa cacacacata tgtagatttc acaaaatcca cctataattg 6300
gtcaaagtgg ttgagaatat attttttagt aattgcatgc aaaatttttc tagcttccat 6360
cctttctccc tcgtttcttc tttttttggg ggagctggta actgatgaaa tcttttccca 6420
ccttttctct tcaggaaata taagtggttt tgtttggtta acgtgataca ttctgtatga 6480
atgaaacatt ggagggaaac atctactgaa tttctgtaat ttaaaatatt ttgctgctag 6540
ttaactatga acagatagaa gaatcttaca gatgctgcta taaataagta gaaaatataa 6600
atttcatcac taaaatatgc tattttaaaa tctatttcct atattgtatt tctaatcaga 6660
tgtattactc ttattatttc tattgtatgt gttaatgatt ttatgtaaaa atgtaattgc 6720
ttttcatgag tagtatgaat aaaattgatt agtttgtgtt ttcttgtctc ccg 6773
<210>49
<211>3537
<212>DNA
<213>人
<400>49
cagaccccag ttcgccgact aagcagaaga aagatcaaaa accggaaaag aggagaagag 60
caaacaggca ctttgaggaa caatcccctt taactccaag ccgacagcgg tctaggaatt 120
caagttcagt gcctaccgaa gacaaaggcg ccccgaggga gtggcggtgc gaccccaggg 180
cgtgggcccg gccgcggagc ccacactgcc cggctgaccc ggtggtctcg gaccatgtct 240
cccgccccaa gacccccccg ttgtctcctg ctccccctgc tcacgctcgg caccgcgctc 300
gcctccctcg gctcggccca aagcagcagc ttcagccccg aagcctggct acagcaatat 360
ggctacctgc ctcccgggga cctacgtacc cacacacagc gctcacccca gtcactctca 420
gcggccatcg ctgccatgca gaagttttac ggcttgcaag taacaggcaa agctgatgca 480
gacaccatga aggccatgag gcgcccccga tgtggtgttc cagacaagtt tggggctgag 540
atcaaggcca atgttcgaag gaagcgctac gccatccagg gtctcaaatg gcaacataat 600
gaaatcactt tctgcatcca gaattacacc cccaaggtgg gcgagtatgc cacatacgag 660
gccattcgca aggcgttccg cgtgtgggag agtgccacac cactgcgctt ccgcgaggtg 720
ccctatgcct acatccgtga gggccatgag aagcaggccg acatcatgat cttctttgcc 780
gagggcttcc atggcgacag cacgcccttc gatggtgagg gcggcttcct ggcccatgcc 840
tacttcccag gccccaacat tggaggagac acccactttg actctgccga gccttggact 900
gtcaggaatg aggatctgaa tggaaatgac atcttcctgg tggctgtgca cgagctgggc 960
catgccctgg ggctcgagca ttccagtgac ccctcggcca tcatggcacc cttttaccag 1020
tggatggaca cggagaattt tgtgctgccc gatgatgacc gccggggcat ccagcaactt 1080
tatgggggtg agtcagggtt ccccaccaag atgccccctc aacccaggac tacctcccgg 1140
ccttctgttc ctgataaacc caaaaacccc acctatgggc ccaacatctg tgacgggaac 1200
tttgacaccg tggccatgct ccgaggggag atgtttgtct tcaaggagcg ctggttctgg 1260
cgggtgagga ataaccaagt gatggatgga tacccaatgc ccattggcca gttctggcgg 1320
ggcctgcctg cgtccatcaa cactgcctac gagaggaagg atggcaaatt cgtcttcttc 1380
aaaggagaca agcattgggt gtttgatgag gcgtccctgg aacctggcta ccccaagcac 1440
attaaggagc tgggccgagg gctgcctacc gacaagattg atgctgctct cttctggatg 1500
cccaatggaa agacctactt cttccgtgga aacaagtact accgtttcaa cgaagagctc 1560
agggcagtgg atagcgagta ccccaagaac atcaaagtct gggaagggat ccctgagtct 1620
cccagagggt cattcatggg cagcgatgaa gtcttcactt acttctacaa ggggaacaaa 1680
tactggaaat tcaacaacca gaagctgaag gtagaaccgg gctaccccaa gtcagccctg 1740
agggactgga tgggctgccc atcgggaggc cggccggatg aggggactga ggaggagacg 1800
gaggtgatca tcattgaggt ggacgaggag ggcggcgggg cggtgagcgc ggctgccgtg 1860
gtgctgcccg tgctgctgct gctcctggtg ctggcggtgg gccttgcagt cttcttcttc 1920
agacgccatg ggacccccag gcgactgctc tactgccagc gttccctgct ggacaaggtc 1980
tgacgcccac cgccggcccg cccactccta ccacaaggac tttgcctctg aaggccagtg 2040
gcagcaggtg gtggtgggtg ggctgctccc atcgtcccga gccccctccc cgcagcctcc 2100
ttgcttctct ctgtcccctg gctggcctcc ttcaccctga ccgcctccct ccctcctgcc 2160
ccggcattgc atcttcccta gataggtccc ctgagggctg agtgggaggg cggccctttc 2220
cagcctctgc ccctcagggg aaccctgtag ctttgtgtct gtccagcccc atctgaatgt 2280
gttgggggct ctgcacttga aggcaggacc ctcagacctc gctggtaaag gtcaaatggg 2340
gtcatctgct ccttttccat cccctgacat accttaacct ctgaactctg acctcaggag 2400
gctctgggca ctccagccct gaaagcccca ggtgtaccca attggcagcc tctcactact 2460
ctttctggct aaaaggaatc taatcttgtt gagggtagag accctgagac agtgtgaggg 2520
ggtggggact gccaagccac cctaagacct tgggaggaaa actcagagag ggtcttcgtt 2580
gctcagtcag tcaagttcct cggagatctg cctctgcctc acctacccca gggaacttcc 2640
aaggaaggag cctgagccac tggggactaa gtgggcagaa gaaacccttg gcagccctgt 2700
gcctctcgaa tgttagcctt ggatggggct ttcacagtta gaagagctga aaccaggggt 2760
gcagctgtca ggtagggtgg ggccggtggg agaggcccgg gtcagagccc tgggggtgag 2820
cctgaaggcc acagagaaag aaccttgccc aaactcaggc agctggggct gaggcccaaa 2880
ggcagaacag ccagaggggg caggagggga ccaaaaagga aaatgaggac gtgcagcagc 2940
attggaaggc tggggccggg caggccaggc caagccaagc agggggccac agggtgggct 3000
gtggagctct caggaagggc cctgaggaag gcacacttgc tcctgttggt ccctgtcctt 3060
gctgcccagg cagcgtggag gggaagggta gggcagccag agaaaggagc agagaaggca 3120
cacaaacgag gaatgagggg cttcacgaga ggccacaggg cctggctggc cacgctgtcc 3180
cggcctgctc accatctcag tgaggggcag gagctggggc tcgcttaggc tgggtccacg 3240
cttccctggt gccagcaccc ctcaagcctg tctcaccagt ggcctgccct ctcgctcccc 3300
cacccagccc acccattgaa gtctccttgg gccaccaaag gtggtggcca tggtaccggg 3360
gacttgggag agtgagaccc agtggaggga gcaagaggag agggatgtcg ggggggtggg 3420
gcacggggta ggggaaatgg ggtgaacggt gctggcagtt cggctagatt tctgtcttgt 3480
ttgttttttt gttttgttta atgtatattt ttattataat tattatatat gaattcc 3537
<210>50
<211>4624
<212>DNA
<213>人
<400>50
ggaggaggtg gaggaggagg gctgcttgag gaagtataag aatgaagttg tgaagctgag 60
attcccctcc attgggaccg gagaaaccag gggagccccc cgggcagccg cgcgcccctt 120
cccacggggc cctttactgc gccgcgcgcc cggcccccac ccctcgcagc accccgcgcc 180
ccgcgccctc ccagccgggt ccagccggag ccatggggcc ggagccgcag tgagcaccat 240
ggagctggcg gccttgtgcc gctgggggct cctcctcgcc ctcttgcccc ccggagccgc 300
gagcacccaa gtgtgcaccg gcacagacat gaagctgcgg ctccctgcca gtcccgagac 360
ccacctggac atgctccgcc acctctacca gggctgccag gtggtgcagg gaaacctgga 420
actcacctac ctgcccacca atgccagcct gtccttcctg caggatatcc aggaggtgca 480
gggctacgtg ctcatcgctc acaaccaagt gaggcaggtc ccactgcaga ggctgcggat 540
tgtgcgaggc acccagctct ttgaggacaa ctatgccctg gccgtgctag acaatggaga 600
cccgctgaac aataccaccc ctgtcacagg ggcctcccca ggaggcctgc gggagctgca 660
gcttcgaagc ctcacagaga tcttgaaagg aggggtcttg atccagcgga acccccagct 720
ctgctaccag gacacgattt tgtggaagga catcttccac aagaacaacc agctggctct 780
cacactgata gacaccaacc gctctcgggc ctgccacccc tgttctccga tgtgtaaggg 840
ctcccgctgc tggggagaga gttctgagga ttgtcagagc ctgacgcgca ctgtctgtgc 900
cggtggctgt gcccgctgca aggggccact gcccactgac tgctgccatg agcagtgtgc 960
tgccggctgc acgggcccca agcactctga ctgcctggcc tgcctccact tcaaccacag 1020
tggcatctgt gagctgcact gcccagccct ggtcacctac aacacagaca cgtttgagtc 1080
tatgcccaat cccgagggcc ggtatacatt cggcgccagc tgtgtgactg cctgtcccta 1140
caactacctt tctacggacg tgggatcctg caccctcgtc tgccccctgc acaaccaaga 1200
ggtgacagca gaggatggaa cacagcggtg tgagaagtgc agcaagccct gtgcccgagt 1260
gtgctatggt ctgggcatgg agcacttgcg agaggtgagg gcagttacca gtgccaatat 1320
ccaggagttt gctggctgca agaagatctt tgggagcctg gcatttctgc cggagagctt 1380
tgatggggac ccagcctcca acactgcccc gctccagcca gagcagctcc aagtgtttga 1440
gactctggaa gagatcacag gttacctata catctcagca tggccggaca gcctgcctga 1500
cctcagcgtc ttccagaacc tgcaagtaat ccggggacga attctgcaca atggcgccta 1560
ctcgctgacc ctgcaagggc tgggcatcag ctggctgggg ctgcgctcac tgagggaact 1620
gggcagtgga ctggccctca tccaccataa cacccacctc tgcttcgtgc acacggtgcc 1680
ctgggaccag ctctttcgga acccgcacca agctctgctc cacactgcca accggccaga 1740
ggacgagtgt gtgggcgagg gcctggcctg ccaccagctg tgcgcccgag ggcactgctg 1800
gggtccaggg cccacccagt gtgtcaactg cagccagttc cttcggggcc aggagtgcgt 1860
ggaggaatgc cgagtactgc aggggctccc cagggagtat gtgaatgcca ggcactgttt 1920
gccgtgccac cctgagtgtc agccccagaa tggctcagtg acctgttttg gaccggaggc 1980
tgaccagtgt gtggcctgtg cccactataa ggaccctccc ttctgcgtgg cccgctgccc 2040
cagcggtgtg aaacctgacc tctcctacat gcccatctgg aagtttccag atgaggaggg 2100
cgcatgccag ccttgcccca tcaactgcac ccactcctgt gtggacctgg atgacaaggg 2160
ctgccccgcc gagcagagag ccagccctct gacgtccatc atctctgcgg tggttggcat 2220
tctgctggtc gtggtcttgg gggtggtctt tgggatcctc atcaagcgac ggcagcagaa 2280
gatccggaag tacacgatgc ggagactgct gcaggaaacg gagctggtgg agccgctgac 2340
acctagcgga gcgatgccca accaggcgca gatgcggatc ctgaaagaga cggagctgag 2400
gaaggtgaag gtgcttggat ctggcgcttt tggcacagtc tacaagggca tctggatccc 2460
tgatggggag aatgtgaaaa ttccagtggc catcaaagtg ttgagggaaa acacatcccc 2520
caaagccaac aaagaaatct tagacgaagc atacgtgatg gctggtgtgg gctccccata 2580
tgtctcccgc cttctgggca tctgcctgac atccacggtg cagctggtga cacagcttat 2640
gccctatggc tgcctcttag accatgtccg ggaaaaccgc ggacgcctgg gctcccagga 2700
cctgctgaac tggtgtatgc agattgccaa ggggatgagc tacctggagg atgtgcggct 2760
cgtacacagg gacttggccg ctcggaacgt gctggtcaag agtcccaacc atgtcaaaat 2820
tacagacttc gggctggctc ggctgctgga cattgacgag acagagtacc atgcagatgg 2880
gggcaaggtg cccatcaagt ggatggcgct ggagtccatt ctccgccggc ggttcaccca 2940
ccagagtgat gtgtggagtt atggtgtgac tgtgtgggag ctgatgactt ttggggccaa 3000
accttacgat gggatcccag cccgggagat ccctgacctg ctggaaaagg gggagcggct 3060
gccccagccc cccatctgca ccattgatgt ctacatgatc atggtcaaat gttggatgat 3120
tgactctgaa tgtcggccaa gattccggga gttggtgtct gaattctccc gcatggccag 3180
ggacccccag cgctttgtgg tcatccagaa tgaggacttg ggcccagcca gtcccttgga 3240
cagcaccttc taccgctcac tgctggagga cgatgacatg ggggacctgg tggatgctga 3300
ggagtatctg gtaccccagc agggcttctt ctgtccagac cctgccccgg gcgctggggg 3360
catggtccac cacaggcacc gcagctcatc taccaggagt ggcggtgggg acctgacact 3420
agggctggag ccctctgaag aggaggcccc caggtctcca ctggcaccct ccgaaggggc 3480
tggctccgat gtatttgatg gtgacctggg aatgggggca gccaaggggc tgcaaagcct 3540
ccccacacat gaccccagcc ctctacagcg gtacagtgag gaccccacag tacccctgcc 3600
ctctgagact gatggctacg ttgcccccct gacctgcagc ccccagcctg aatatgtgaa 3660
ccagccagat gttcggcccc agcccccttc gccccgagag ggccctctgc ctgctgcccg 3720
acctgctggt gccactctgg aaaggcccaa gactctctcc ccagggaaga atggggtcgt 3780
caaagacgtt tttgcctttg ggggtgccgt ggagaacccc gagtacttga caccccaggg 3840
aggagctgcc cctcagcccc accctcctcc tgccttcagc ccagccttcg acaacctcta 3900
ttactgggac caggacccac cagagcgggg ggctccaccc agcaccttca aagggacacc 3960
tacggcagag aacccagagt acctgggtct ggacgtgcca gtgtgaacca gaaggccaag 4020
tccgcagaag ccctgatgtg tcctcaggga gcagggaagg cctgacttct gctggcatca 4080
agaggtggga gggccctccg accacttcca ggggaacctg ccatgccagg aacctgtcct 4140
aaggaacctt ccttcctgct tgagttccca gatggctgga aggggtccag cctcgttgga 4200
agaggaacag cactggggag tctttgtgga ttctgaggcc ctgcccaatg agactctagg 4260
gtccagtgga tgccacagcc cagcttggcc ctttccttcc agatcctggg tactgaaagc 4320
cttagggaag ctggcctgag aggggaagcg gccctaaggg agtgtctaag aacaaaagcg 4380
acccattcag agactgtccc tgaaacctag tactgccccc catgaggaag gaacagcaat 4440
ggtgtcagta tccaggcttt gtacagagtg cttttctgtt tagtttttac tttttttgtt 4500
ttgttttttt aaagatgaaa taaagaccca gggggagaat gggtgttgta tggggaggca 4560
agtgtggggg gtccttctcc acacccactt tgtccatttg caaatatatt ttggaaaaca 4620
gcta 4624
<210>51
<211>69
<212>DNA
<213>人
<400>51
gagtgtcttt ctttgcaggt ttctgtagcc ggaagatctc cgttccgctc ccagcggctc 60
cagtgtaaa 69
<210>52
<211>70
<212>DNA
<213>人
<400>52
aagagaccat ctgcccgagt agccgcaaat gtgcttcatc taagcctctg gggtgaacat 60
attctagccc 70
<210>53
<211>69
<212>DNA
<213>人
<400>53
accgaagaaa ctgtggctac ccgggcatca gccccgagga atgcgcctct cggaagtgct 60
gcttctcca 69
<210>54
<211>69
<212>DNA
<213>人
<400>54
acacagccga gcagcatttc cgttgaagga cttgcatccc cattgcgggc agtgctggac 60
gtgtcccgg 69
<210>55
<211>70
<212>DNA
<213>人
<400>55
acaaacgggc tcatcataat gcactggaac gaaaacgtag ggaccacatc aaagacagct 60
ttcacagttt 70
<210>56
<211>69
<212>DNA
<213>人
<400>56
tccagcccat ccagcaatcg ccccctttct gccctggggg cccaggatgt agatattgta 60
caaaggttt 69
<210>57
<211>70
<212>DNA
<213>人
<400>57
agtatggctg cagtcctccg gttgcatact ggactcttca aaaactgttt tgggtagctg 60
ccacttgaac 70
<210>58
<211>69
<212>DNA
<213>人
<400>58
ccggagtcac cccgatgatt actcttttca gacacagcgg tttttgtttc caagaagcca 60
aaattgttt 69
<210>59
<211>69
<212>DNA
<213>人
<400>59
tctccacaat gcaagctaca gagctgggga agttgccggc tggaggagtt ctctaccctc 60
caccttcct 69
<210>60
<211>69
<212>DNA
<213>人
<400>60
gctgggcttc attagtgagg ctgaccagag ccggttgact tctctgctag aagagacctt 60
gaacaagtt 69
<210>61
<211>69
<212>DNA
<213>人
<400>61
ggcgacagga acgtgtctag gcgaacgact aaagcacctg gaaaggctga tccggagttc 60
aagggaaga 69
<210>62
<211>69
<212>DNA
<213>人
<400>62
cattcgggcc atttccgtgg tttctcatga gctgtgttca cagacctcag cagggcatcg 60
catggaccg 69
<210>63
<211>69
<212>DNA
<213>人
<400>63
agatagtgct ctgtgcctaa ggtgaagcca cactagggtg aagcctcact tccctgtttg 60
agcaatgca 69
<210>64
<211>70
<212>DNA
<213>人
<400>64
tggggaggga tggcccagcc tgtaagatac tgtatatgcg ctgctgtaga taccggaatg 60
aattttctgt 70
<210>65
<211>69
<212>DNA
<213>人
<400>65
tcacattcag gcccctgttc ttcaagctgt ttgattgggc taaaacagaa gatgccccaa 60
aggacaggt 69
<210>66
<211>69
<212>DNA
<213>人
<400>66
attatgatta ctatatccga ggagcaacaa ccactttctc tgcagtggaa agggatcgcc 60
agtggaagt 69
<210>67
<211>69
<212>DNA
<213>人
<400>67
caccaggagt accgttagct ttccccttct tctggcccat ttgactcatc agcacaatag 60
ggtcaccac 69
<210>68
<211>69
<212>DNA
<213>人
<400>68
acccccagca cagggggatt ctgagcagtg cctcttgtct gagggacata tcagtgacct 60
cgacgttgc 69
<210>69
<211>69
<212>DNA
<213>人
<400>69
tctgtgatgt aggagtctct ctaccactgg atgaaaatat gactgtgact gaccctgagg 60
cttgttaca 69
<210>70
<211>69
<212>DNA
<213>人
<400>70
ctccacagcg gttcttcaca ggatcccagc aatgaactgt tctagggaaa gtggcttcct 60
gcccaaact 69
<210>71
<211>69
<212>DNA
<213>人
<400>71
atgggaagga agggaccctt acccccggct cttctcctga cctgccaata aaaatttatg 60
gtccaaggg 69
<210>72
<211>69
<212>DNA
<213>人
<400>72
cttggcaact gctagagcag ggagggggga gggcagggga ttacctaatt agagtgggtt 60
agcttagat 69
<210>73
<211>69
<212>DNA
<213>人
<400>73
gtcctcattc cctgcccttc ctttggttgc catatggaat ggccatggaa tgcacgaagt 60
cacaatgca 69
<210>74
<211>69
<212>DNA
<213>人
<400>74
tctcttgaga ctcgttactg ggcatcagta gaagaatata ttcccaaatg ggaacagttt 60
cttttagga 69
<210>75
<211>69
<212>DNA
<213>人
<400>75
tggtatccag aatggaattt tgctacatgg ggtctgggtg ggggcaaaga gacccagtca 60
attacatgt 69
<210>76
<211>69
<212>DNA
<213>人
<400>76
ctattctgga ggcaccaagg aactagcaga gatgatgaat gcatcatcaa gcacgaccac 60
attgtttcc 69
<210>77
<211>69
<212>DNA
<213>人
<400>77
tcaggtgggc cttgagttat attttaactc agctgctcag ttcccagggc acatttctgg 60
atcagaacc 69
<210>78
<211>70
<212>DNA
<213>人
<400>78
gggagataca gccatccacc ttcagatgtg tctacgtgcg ctctgccatt caactcggaa 60
actataagta 70
<210>79
<211>69
<212>DNA
<213>人
<400>79
aattaaagtt atagacaaga tgggagggcc agaagagttt atccagagat tcctccctcg 60
ggagctcca 69
<210>80
<211>70
<212>DNA
<213>人
<400>80
cagctttgct ttgcaaagat tgatgacaga ctggttcctc agaggcctag gctacccgtc 60
accccttttt 70
<210>81
<211>70
<212>DNA
<213>人
cctcctgggg agtgtcattt ttgtctacag cttcattgac ttccacgtgt tccaccgcaa 60
agatagccgc 70
<210>82
<211>60
<212>DNA
<213>人
<400>82
gaaggagggg ctgggccagg gccagtcgct ggaacagctg gaagctctgg tgcaaaccaa 60
<210>83
<211>69
<212>DNA
<213>人
<400>83
ggtgggggaa cactgagaaa gaggcaggga cctaaaggga ctacctctgt gccttgccac 60
attaaattg 69
<210>84
<211>69
<212>DNA
<213>人
<400>84
ggcaagatct atcggcaggg aaacctgttt gacttcttac gcttgacgga atggcgtggc 60
ccccgcgtg 69
<210>85
<211>69
<212>DNA
<213>人
<400>85
aggctaggtg ggttgaaagc caaggagtca ctgagaccaa ggctttctct actgattccg 60
cagctcaga 69
<210>86
<211>69
<212>DNA
<213>人
<400>86
tgactagcga gggacctccg ctgcatctca gcaaagcccc tcccagggtt tgatcgattg 60
agcaggaca 69
<210>87
<211>69
<212>DNA
<213>人
<400>87
tcctctgtca tactgtatct ggaatgcttt gtaatacttg catgcttctt agaccagaac 60
atgtaggtc 69
<210>88
<211>69
<212>DNA
<213>人
<400>88
agctcctcgg agggaacaga gcggctgtgt atgcagcctg caggtttcca tacactgaag 60
cttttacct 69
<210>89
<211>69
<212>DNA
<213>人
<400>89
gtaggctgag ggctgcacct cccacggtgg tcaccatgcc aatgaaggaa gttcagtctt 60
gtctttgat 69
<210>90
<211>70
<212>DNA
<213>人
<400>90
acctcgaggc acttacttgc aagtcagggg caagagacaa taattaaaac caaagtcaga 60
atcccagcac 70
<210>91
<211>69
<212>DNA
<213>人
<400>91
attcctgcca ccactgggca aacagaagaa tttttctgtc tttggagagt attttagaaa 60
ctccaatga 69
<210>92
<211>70
<212>DNA
<213>人
<400>92
gagaaccaga agacgatgag gctcctgcaa aagctcagta ctacacagtg acagatgagc 60
atcacagatc 70
<210>93
<211>69
<212>DNA
<213>人
<400>93
ttctcccagg atggtgaagg gggacctggt acccagtgat ccccacccca ggatcctaaa 60
tcatgactt 69
<210>94
<211>70
<212>DNA
<213>人
<400>94
cagtgtttca aatgccgtga aacatggcat catgctctaa cttcagtata ccaataaaac 60
aatcagcttg 70
<210>95
<211>69
<212>DNA
<213>人
<400>95
tcgattcagt cataggcgaa tctgttctgc ccgaggcttg tggtcaagca aaaattcagc 60
cctgaaatc 69
<210>96
<211>69
<212>DNA
<213>人
<400>96
tgcaattacg tccaccaaag acccgtgttg ggggtactga aggagaggcc ctgggggacc 60
ctctgaagc 69
<210>97
<211>71
<212>DNA
<213>人
<400>97
gggaaaactt gctgcggttg ctcaaggtga ggaataaaat gcttcccgtt cttctggatg 60
ggcatcctat c 71
<210>98
<211>69
<212>DNA
<213>人
<400>98
atataaaaga tacacaccaa tatcttcttc aggctctgac aggcctcctg gaaacttcca 60
catattttt 69
<210>99
<211>70
<212>DNA
<213>人
<400>99
agctcagggc agtggatagc gagtacccca agaacatcaa agtctgggaa gggatccctg 60
agtctcccag 70
<210>100
<211>69
<212>DNA
<213>人
<400>100
gactgtccct gaaacctagt actgcccccc atgaggaagg aacagcaatg gtgtcagtat 60
ccaggcttt 69
<210>101
<211>306
<212>PRT
<213>人
<400>101
Met Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Ala Ala Gly Gly
1 5 10 15
Arg Gly Ser Gly Pro Gly Arg Arg Arg His Leu Val Pro Gly Ala Gly
20 25 30
Gly Glu Ala Gly Glu Gly Ala Pro Gly Gly Ala Gly Asp Tyr Gly Asn
35 40 45
Gly Leu Glu Ser Glu Glu Leu Glu Pro Glu Glu Leu Leu Leu Glu Pro
50 55 60
Glu Pro Glu Pro Glu Pro Glu Glu Glu Pro Pro Arg Pro Arg Ala Pro
65 70 75 80
Pro Gly Ala Pro Gly Pro Gly Pro Gly Ser Gly Ala Pro Gly Ser Gln
85 90 95
Glu Glu Glu Glu Glu Pro Gly Leu Val Glu Gly Asp Pro Gly Asp Gly
100 105 110
Ala Ile Glu Asp Pro Glu Leu Glu Ala Ile Lys Ala Arg Val Arg Glu
115 120 125
Met Glu Glu Glu Ala Glu Lys Leu Lys Glu Leu Gln Asn Glu ValGlu
130 135 140
Lys Gln Met Asn Met Ser Pro Pro Pro Gly Asn Ala Gly Pro Val Ile
145 150 155 160
Met Ser Ile Glu Glu Lys Met Glu Ala Asp Ala Arg Ser Ile Tyr Val
165 170 175
Gly Asn Val Asp Tyr Gly Ala Thr Ala Glu Glu Leu Glu Ala His Phe
180 185 190
His Gly Cys Gly Ser Val Asn Arg ValThr Ile Leu Cys Asp Lys Phe
195 200 205
Ser Gly His Pro Lys Gly Phe Ala Tyr Ile Glu Phe Ser Asp Lys Glu
210 215 220
Ser Val Arg Thr Ser Leu Ala Leu Asp Glu Ser Leu Phe Arg Gly Arg
225 230 235 240
Gln Ile Lys Val Ile Pro Lys Arg Thr Asn Arg Pro Gly Ile Ser Thr
245 250 255
Thr Asp Arg Gly Phe Pro Arg Ala Arg Tyr Arg Ala Arg Thr Thr Asn
260 265 270
Tyr Asn Ser Ser Arg Ser Arg Phe Tyr Ser Gly Phe Asn Ser Arg Pro
275 280 285
Arg Gly Arg Val Tyr Arg Gly Arg Ala Arg Ala Thr Ser Trp Tyr Ser
290 295 300
Pro Tyr
305
<210>102
<211>581
<212>PRT
<213>人
<400>102
Met Ala Val Arg Gln Ala Leu Gly Arg Gly Leu Gln Leu Gly Arg Ala
1 5 10 15
Leu Leu Leu Arg Phe Thr Gly Lys Pro Gly Arg Ala Tyr Gly Leu Gly
20 25 30
Arg Pro Gly Pro Ala Ala Gly Cys Val Arg Gly Glu Arg Pro Gly Trp
35 40 45
Ala Ala Gly Pro Gly Ala Glu Pro Arg Arg Val Gly Leu Gly Leu Pro
50 55 60
Asn Arg Leu Arg Phe Phe Arg Gln Ser Val Ala Gly Leu Ala Ala Arg
65 70 75 80
Leu Gln Arg Gln Phe Val Val Arg Ala Trp Gly Cys Ala Gly Pro Cys
85 90 95
Gly Arg Ala Val Phe Leu Ala Phe Gly Leu Gly Leu Gly Leu Ile Glu
100 105 110
Glu Lys Gln Ala Glu Ser Arg Arg Ala Val Ser Ala Cys Gln Glu Ile
115 120 125
Gln Ala Ile Phe Thr Gln Lys Ser Lys Pro Gly Pro Asp Pro Leu Asp
130 135 140
Thr Arg Arg Leu Gln Gly Phe Arg Leu Glu Glu Tyr Leu Ile Gly Gln
145 150 155 160
Ser Ile Gly Lys Gly Cys Ser Ala Ala Val Tyr Glu Ala Thr Met Pro
165 170 175
Thr Leu Pro Gln Asn Leu Glu Val Thr Lys Ser Thr Gly Leu Leu Pro
180 185 190
Gly Arg Gly Pro Gly Thr Ser Ala Pro Gly Glu Gly Gln Glu Arg Ala
195 200 205
Pro Gly Ala Pro Ala Phe Pro Leu Ala Ile Lys Met Met Trp Asn Ile
210 215 220
Ser Ala Gly Ser Ser Ser Glu Ala Ile Leu Asn Thr Met Ser Gln Glu
225 230 235 240
Leu Val Pro Ala Ser Arg Val Ala Leu Ala Gly Glu Tyr Gly Ala Val
245 250 255
Thr Tyr Arg Lys Ser Lys Arg Gly Pro Lys Gln Leu Ala Pro His Pro
260 265 270
Asn Ile Ile Arg Val Leu Arg Ala Phe Thr Ser Ser Val Pro Leu Leu
275 280 285
Pro Gly Ala Leu Val Asp Tyr Pro Asp Val Leu Pro Ser Arg Leu His
290 295 300
Pro Glu Gly Leu Gly His Gly Arg Thr Leu Phe Leu Val Met Lys Asn
305 310 315 320
Tyr Pro Cys Thr Leu Arg Gln Tyr Leu Cys Val Asn Thr Pro Ser Pro
325 330 335
Arg Leu Ala Ala Met Met Leu Leu Gln Leu Leu Glu Gly Val Asp His
340 345 350
Leu Val Gln Gln Gly Ile Ala His Arg Asp Leu Lys Ser Asp Asn Ile
355 360 365
Leu Val Glu Leu Asp Pro Asp Gly Cys Pro Trp Leu Val Ile Ala Asp
370 375 380
Phe Gly Cys Cys Leu Ala Asp Glu Ser Ile Gly Leu Gln Leu Pro Phe
385 390 395 400
Ser Ser Trp Tyr Val Asp Arg Gly Gly Asn Gly Cys Leu Met Ala Pro
405 410 415
Glu Val Ser Thr Ala Arg Pro Gly Pro Arg Ala Val Ile Asp Tyr Ser
420 425 430
Lys Ala Asp Ala Trp Ala Val Gly Ala Ile Ala Tyr Glu Ile Phe Gly
435 440 445
Leu Val Asn Pro Phe Tyr Gly Gln Gly Lys Ala His Leu Glu Ser Arg
450 455 460
Ser Tyr Gln Glu Ala Gln Leu Pro Ala Leu Pro Glu Ser Val Pro Pro
465 470 475 480
Asp Val Arg Gln Leu Val Arg Ala Leu Leu Gln Arg Glu Ala Ser Lys
485 490 495
Arg Pro Ser Ala Arg Val Ala Ala Asn Val Leu His Leu Ser Leu Trp
500 505 510
Gly Glu His Ile Leu Ala Leu Lys Asn Leu Lys Leu Asp Lys Met Val
515 520 525
Gly Trp Leu Leu Gln Gln Ser Ala Ala Thr Leu Leu Ala Asn Arg Leu
530 535 540
Thr Glu Lys Cys Cys Val Glu Thr Lys Met Lys Met Leu Phe Leu Ala
545 550 555 560
Asn Leu Glu Cys Glu Thr Leu Cys Gln Ala Ala Leu Leu Leu Cys Ser
565 570 575
Trp Arg Ala Ala Leu
580
<210>103
<211>129
<212>PRT
<213>人
<400>103
Met Gly Arg Arg Asp Ala Gln Leu Leu Ala Ala Leu Leu Val Leu Gly
1 5 10 15
Leu Cys Ala Leu Ala Gly Ser Glu Lys Pro Ser Pro Cys Gln Cys Ser
20 25 30
Arg Leu Ser Pro His Asn Arg Thr Asn Cys Gly Phe Pro Gly Ile Thr
35 40 45
Ser Asp Gln Cys Phe Asp Asn Gly Cys Cys Phe Asp Ser Ser Val Thr
50 55 60
Gly Val Pro Trp Cys Phe His Pro Leu Pro Lys Gln Glu Ser Asp Gln
65 70 75 80
Cys Val Met Glu Val Ser Asp Arg Arg Asn Cys Gly Tyr Pro Gly Ile
85 90 95
Ser Pro Glu Glu Cys Ala Ser Arg Lys Cys Cys Phe Ser Asn Phe Ile
100 105 110
Phe Glu Val Pro Trp Cys Phe Phe Pro Lys Ser Val Glu Asp Cys His
115 120 125
Tyr
<210>104
<211>814
<212>PRT
<213>人
<400>104
Met Gln Asp Ala Glu Asn Val Ala Val Pro Glu Ala Ala Glu Glu Arg
1 5 10 15
Ala Glu Pro Gly Gln Gln Gln Pro Ala Ala Glu Pro Pro Pro Ala Glu
20 25 30
Gly Leu Leu Arg Pro Ala Gly Pro Gly Ala Pro Glu Ala Ala Gly Thr
35 40 45
Glu Ala Ser Ser Glu Glu Val Gly Ile Ala Glu Ala Gly Pro Glu Ser
50 55 60
Glu Val Arg Thr Glu Pro Ala Ala Glu Ala Glu Ala Ala Ser Gly Pro
65 70 75 80
Ser Glu Ser Pro Ser Pro Pro Ala Ala Glu Glu Leu Pro Gly Ser His
85 90 95
Ala Glu Pro Pro Val Pro Ala Gln Gly Glu Ala Pro Gly Glu Gln Ala
100 105 110
Arg Asp Glu Arg Ser Asp Ser Arg Ala Gln Ala Val Ser Glu Asp Ala
115 120 125
Gly Gly Asn Glu Gly Arg Ala Ala Glu Ala Glu Pro Arg Ala Leu Glu
130 135 140
Asn Gly Asp Ala Asp Glu Pro Ser Phe Ser Asp Pro Glu Asp Phe Val
145 150 155 160
Asp Asp Val Ser Glu Glu Glu Leu Leu Gly Asp Val Leu Lys Asp Arg
165 170 175
Pro Gln Glu Ala Asp Gly Ile Asp Ser Val Ile ValVal Asp Asn Val
180 185 190
Pro Gln Val Gly Pro Asp Arg Leu Glu Lys Leu Lys Asn Val Ile His
195 200 205
Lys Ile Phe Ser Lys Phe Gly Lys Ile Thr Asn Asp Phe Tyr Pro Glu
210 215 220
Glu Asp Gly Lys Thr Lys Gly Tyr Ile Phe Leu Glu Tyr Ala Ser Pro
225 230 235 240
Ala His Ala Val Asp Ala Val Lys Asn Ala Asp Gly Tyr Lys Leu Asp
245 250 255
Lys Gln His Thr Phe Arg Val Asn Leu Phe Thr Asp Phe Asp Lys Tyr
260 265 270
Met Thr Ile Ser Asp Glu Trp AspIle Pro Glu Lys Gln Pro Phe Lys
275 280 285
Asp Leu Gly Asn Leu Arg Tyr Trp Leu Glu Glu Ala Glu Cys Arg Asp
290 295 300
Gln Tyr Ser Val Ile Phe Glu Ser Gly Asp Arg Thr Ser Ile Phe Trp
305 310 315 320
Asn Asp Val Lys Asp Pro Val Ser Ile Glu Glu Arg Ala Arg Trp Thr
325 330 335
Glu Thr Tyr Val Arg Trp Ser Pro Lys Gly Thr Tyr Leu Ala Thr Phe
340 345 350
His Gln Arg Gly Ile Ala Leu Trp Gly Gly Glu Lys Phe Lys Gln Ile
355 360 365
Gln Arg Phe Ser His Gln Gly Val Gln Leu Ile Asp Phe Ser Pro Cys
370 375 380
Glu Arg Tyr Leu Val Thr Phe Ser Pro Leu Met Asp Thr Gln Asp Asp
385 390 395 400
Pro Gln Ala Ile Ile Ile Trp Asp Ile Leu Thr Gly His Lys Lys Arg
405 410 415
Gly Phe His Cys Glu Ser Ser Ala His Trp Pro Ile Phe Lys Trp Ser
420 425 430
His Asp Gly Lys Phe Phe Ala Arg Met Thr Leu Asp Thr Leu Ser Ile
435 440 445
Tyr Glu Thr Pro Ser Met Gly Leu Leu Asp Lys Lys Ser Leu Lys Ile
450 455 460
Ser Gly Ile Lys Asp Phe Ser Trp Ser Pro Gly Gly Asn Ile Ile Ala
465 470 475 480
Phe Trp Val Pro Glu Asp Lys Asp Ile Pro Ala Arg Val Thr Leu Met
485 490 495
Gln Leu Pro Thr Arg Gln Glu Ile Arg Val Arg Asn Leu Phe Asn Val
500 505 510
Val Asp Cys Lys Leu His Trp Gln Lys Asn Gly Asp Tyr Leu Cys Val
515 520 525
Lys Val Asp Arg Thr Pro Lys Gly Thr Gln Gly Val Val Thr Asn Phe
530 535 540
Glu Ile Phe Arg Met Arg Glu Lys Gln Val Pro Val Asp Val Val Glu
545 550 555 560
Met Lys Glu Thr Ile Ile Ala Phe Ala Trp Glu Pro Asn Gly Ser Lys
565 570 575
Phe Ala Val Leu His Gly Glu Ala Pro Arg Ile Ser Val Ser Phe Tyr
580 585 590
His Val Lys Asn Asn Gly Lys Ile Glu Leu Ile Lys Met Phe Asp Lys
595 600 605
Gln Gln Ala Asn Thr Ile Phe Trp Ser Pro Gln Gly Gln Phe Val Val
610 615 620
Leu Ala Gly Leu Arg Ser Met Asn Gly Ala Leu Ala Phe Val Asp Thr
625 630 635 640
Ser Asp Cys Thr Val Met Asn Ile Ala Glu His Tyr Met Ala Ser Asp
645 650 655
Val Glu Trp Asp Pro Thr Gly Arg Tyr Val Val Thr Ser Val Ser Trp
660 665 670
Trp Ser His Lys Val Asp Asn Ala Tyr Trp Leu Trp Thr Phe Gln Gly
675 680 685
Arg Leu Leu Gln Lys Asn Asn Lys Asp Arg Phe Cys Gln Leu Leu Trp
690 695 700
Arg Pro Arg Pro Pro Thr Leu Leu Ser Gln Glu Gln Ile Lys Gln Ile
705 710 715 720
Lys Lys Asp Leu Lys Lys Tyr Ser Lys Ile Phe Glu Gln Lys Asp Arg
725 730 735
Leu Ser Gln Ser Lys Ala Ser Lys Glu Leu Val Glu Arg Arg Arg Thr
740 745 750
Met Met Glu Asp Phe Arg Lys Tyr Arg Lys Met Ala Gln Glu Leu Tyr
755 760 765
Met Glu Gln Lys Asn Glu Arg Leu Glu Leu Arg Gly Gly Val Asp Thr
770 775 780
Asp Glu Leu Asp Ser Asn Val Asp Asp Trp Glu Glu Glu Thr Ile Glu
785 790 795 800
Phe Phe Val Thr Glu Glu Ile Ile Pro Leu Gly Asn Gln Glu
805 810
<210>105
<211>160
<212>PRT
<213>人
<400>105
Met Ser Asp Asn Asp Asp Ile Glu Val Glu Ser Asp Glu Glu Gln Pro
1 5 10 15
Arg Phe Gln Ser Ala Ala Asp Lys Arg Ala His His Asn Ala Leu Glu
20 25 30
Arg Lys Arg Arg Asp His Ile Lys Asp Ser Phe His Ser Leu Arg Asp
35 40 45
Ser Val Pro Ser Leu Gln Gly Glu Lys Ala Ser Arg Ala Gln Ile Leu
50 55 60
Asp Lys Ala Thr Glu Tyr Ile Gln Tyr Met Arg Arg Lys Asn His Thr
65 70 75 80
His Gln Gln Asp Ile Asp Asp Leu Lys Arg Gln Asn Ala Leu Leu Glu
85 90 95
Gln Gln Val Arg Ala Leu Glu Lys Ala Arg Ser Ser Ala Gln Leu Gln
100 105 110
Thr Asn Tyr Pro Ser Ser Asp Asn Ser Leu Tyr Thr Asn Ala Lys Gly
115 120 125
Ser Thr Ile Ser Ala Phe Asp Gly Gly Ser Asp Ser Ser Ser Glu Ser
130 135 140
Glu Pro Glu Glu Pro Gln Ser Arg Lys Lys Leu Arg Met Glu Ala Ser
145 150 155 160
<210>106
<211>2715
<212>PRT
<213>人
<400>106
Met Ala Ala Ala Ala Gly Gly Gly Ser Cys Pro Gly Pro Gly Ser Ala
1 5 10 15
Arg Gly Arg Phe Pro Gly Arg Pro Arg Gly Ala Gly Gly Gly Gly Gly
20 25 30
Arg Gly Gly Arg Gly Asn Gly Ala Glu Arg Val Arg Val Ala Leu Arg
35 40 45
Arg Gly Gly Gly Ala Thr Gly Pro Gly Gly Ala Glu Pro Gly Glu Asp
50 55 60
Thr Ala Leu Leu Arg Leu Leu Gly Leu Arg Arg Gly Leu Arg Arg Leu
65 70 75 80
Arg Arg Leu Trp Ala Gly Pro Arg Val Gln Arg Gly Arg Gly Arg Gly
85 90 95
Arg Gly Arg Gly Trp Gly Pro Ser Arg Gly Cys Val Pro Glu Glu Glu
100 105 110
Ser Ser Asp Gly Glu Ser Asp Glu Glu Glu Phe Gln Gly Phe His Ser
115 120 125
Asp Glu Asp Val Ala Pro Ser Ser Leu Arg Ser Ala Leu Arg Ser Gln
130 135 140
Arg Gly Arg Ala Pro Arg Gly Arg Gly Arg Lys His Lys Thr Thr Pro
145 150 155 160
Leu Pro Pro Pro Arg Leu Ala Asp Val Ala Pro Thr Pro Pro Lys Thr
165 170 175
Pro Ala Arg Lys Arg Gly Glu Glu Gly Thr Glu Arg Met Val Gln Ala
180 185 190
Leu Thr Glu Leu Leu Arg Arg Ala Gln Ala Pro Gln Ala Pro Arg Ser
195 200 205
Arg Ala Cys Glu Pro Ser Thr Pro Arg Arg Ser Arg Gly Arg Pro Pro
210 215 220
Gly Arg Pro Ala Gly Pro Cys Arg Arg Lys Gln Gln Ala Val Val Val
225 230 235 240
Ala Glu Ala Ala Val Thr Ile Pro Lys Pro Glu Pro Pro Pro Pro Val
245 250 255
Val Pro Val Lys His Gln Thr Gly Ser Trp Lys Cys Lys Glu Gly Pro
260 265 270
Gly Pro Gly Pro Gly Thr Pro Arg Arg Gly Gly Gln Ser Ser Arg Gly
275 280 285
Gly Arg Gly Gly Arg Gly Arg Gly Arg Gly Gly Gly Leu Pro Phe Val
290 295 300
Ile Lys Phe Val Ser Arg Ala Lys Lys Val Lys Met Gly Gln Leu Ser
305 310 315 320
Leu Gly Leu Glu Ser Gly Gln Gly Gln Gly Gln His Glu Glu Ser Trp
325 330 335
Gln Asp Val Pro Gln Arg Arg Val Gly Ser Gly Gln Gly Gly Ser Pro
340 345 350
Cys Trp Lys Lys Gln Glu Gln Lys Leu Asp Asp Glu Glu Glu Glu Lys
355 360 365
Lys Glu Glu Glu Glu Lys Asp Lys Glu Gly Glu Glu Lys Glu Glu Arg
370 375 380
Ala Val Ala Glu Glu Met Met Pro Ala Ala Glu Lys Glu Glu Ala Lys
385 390 395 400
Leu Pro Pro Pro Pro Leu Thr Pro Pro Ala Pro Ser Pro Pro Pro Pro
405 410 415
Leu Pro Pro Pro Ser Thr Ser Pro Pro Pro Pro Leu Cys Pro Pro Pro
420 425 430
Pro Pro Pro Val Ser Pro Pro Pro Leu Pro Ser Pro Pro Pro Pro Pro
435 440 445
Ala Gln Glu Glu Gln Glu Glu Ser Pro Pro Pro Val Val Pro Ala Thr
450 455 460
Cys Ser Arg Lys Arg Gly Arg Pro Pro Leu Thr Pro Ser Gln Arg Ala
465 470 475 480
Glu Arg Glu Ala Ala Arg Ala Gly Pro Glu Gly Thr Ser Pro Pro Thr
485 490 495
Pro Thr Pro Ser Thr Ala Thr Gly Gly Pro Pro Glu Asp Ser Pro Thr
500 505 510
Val Ala Pro Lys Ser Thr Thr Phe Leu Lys Asn Ile Arg Gln Phe Ile
515 520 525
Met Pro Val Val Ser Ala Arg Ser Ser Arg Val Ile Lys Thr Pro Arg
530 535 540
Arg Phe Met Asp Glu Asp Pro Pro Lys Pro Pro Lys Val Glu Val Ser
545 550 555 560
Pro Val Leu Arg Pro Pro Ile Thr Thr Ser Pro Pro Val Pro Gln Glu
565 570 575
Pro Ala Pro Val Pro Ser Pro Pro Arg Ala Pro Thr Pro Pro Ser Thr
580 585 590
Pro Val Pro Leu Pro Glu Lys Arg Arg Ser Ile Leu Arg Glu Pro Thr
595 600 605
Phe Arg Trp Thr Ser Leu Thr Arg Glu Leu Pro Pro Pro Pro Pro Ala
610 615 620
Pro Pro Pro Pro Pro Ala Pro Ser Pro Pro Pro Ala Pro Ala Thr Ser
625 630 635 640
Ser Arg Arg Pro Leu Leu Leu Arg Ala Pro Gln Phe Thr Pro Ser Glu
645 650 655
Ala His Leu Lys Ile Tyr Glu Ser Val Leu Thr Pro Pro Pro Leu Gly
660 665 670
Ala Pro Glu Ala Pro Glu Pro Glu Pro Pro Pro Ala Asp Asp Ser Pro
675 680 685
Ala Glu Pro Glu Pro Arg Ala Val Gly Arg Thr Asn His Leu Ser Leu
690 695 700
Pro Arg Phe Ala Pro Val Val Thr Thr Pro Val Lys Ala Glu Val Ser
705 710 715 720
Pro His Gly Ala Pro Ala Leu Ser Asn Gly Pro Gln Thr Gln Ala Gln
725 730 735
Leu Leu Gln Pro Leu Gln Ala Leu Gln Thr Gln Leu Leu Pro Gln Ala
740 745 750
Leu Pro Pro Pro Gln Pro Gln Leu Gln Pro Pro Pro Ser Pro Gln Gln
755 760 765
Met Pro Pro Leu Glu Lys Ala Arg Ile Ala Gly Val Gly Ser Leu Pro
770 775 780
Leu Ser Gly ValGlu Glu Lys Met Phe Ser Leu Leu Lys Arg Ala Lys
785 790 795 800
Val Gln Leu Phe Lys Ile Asp Gln Gln Gln Gln Gln Lys Val Ala Ala
805 810 815
Ser Met Pro Leu Ser Pro Gly Gly Gln Met Glu Glu Val Ala Gly Ala
820 825 830
Val Lys Gln Ile Ser Asp Arg Gly Pro Val Arg Ser Glu Asp Glu Ser
835 840 845
Val Glu Ala Lys Arg Glu Arg Pro Ser Gly Pro Glu Ser Pro Val Gln
850 855 860
Gly Pro Arg Ile Lys His Val Cys Arg His Ala Ala Val Ala Leu Gly
865 870 875 880
Gln Ala Arg Ala Met Val Pro Glu Asp Val Pro Arg Leu Ser Ala Leu
885 890 895
Pro Leu Arg Asp Arg Gln Asp Leu Ala Thr Glu Asp Thr Ser Ser Ala
900 905 910
Ser Glu Thr Glu Ser Val Pro Ser Arg Ser Arg Arg Gly Lys Val Glu
915 920 925
Ala Ala Gly Pro Gly Gly Glu Ser Glu Pro Thr Gly Ser Gly Gly Thr
930 935 940
Leu Ala His Thr Pro Arg Arg Ser Leu Pro Ser His His Gly Lys Lys
945 950 955 960
Met Arg Met Ala Arg Cys Gly His Cys Arg Gly Cys Leu Arg Val Gln
965 970 975
Asp Cys Gly Ser Cys Val Asn Cys Leu Asp Lys Pro Lys Phe Gly Gly
980 985 990
Pro Asn Thr Lys Lys Gln Cys Cys Val Tyr Arg Lys Cys Asp Lys Ile
995 1000 1005
Glu Ala Arg Lys Met Glu Arg Leu Ala Lys Lys Gly Arg Thr Ile
1010 1015 1020
Val Lys Thr Leu Leu Pro Trp Asp Ser Asp Glu Ser Pro Glu Ala
1025 1030 1035
Ser Pro Gly Pro Pro Gly Pro Arg Arg Gly Ala Gly Ala Gly Gly
1040 1045 1050
Pro Arg Glu Glu Val Val Ala His Pro Gly Pro Glu Glu Gln Asp
1055 1060 1065
Ser Leu Leu Gln Arg Lys Ser Ala Arg Arg Cys Val Lys Gln Arg
1070 1075 1080
Pro Ser Tyr Asp Ile Phe Glu Asp Ser Asp Asp Ser Glu Pro Gly
1085 1090 1095
Gly Pro Pro Ala Pro Arg Arg Arg Thr Pro Arg Glu Asn Glu Leu
1100 1105 1110
Pro Leu Pro Glu Pro Glu Glu Gln Ser Arg Pro Arg Lys Pro Thr
1115 1120 1125
Leu Gln Pro Val Leu Gln Leu Lys Ala Arg Arg Arg Leu Asp Lys
1130 1135 1140
Asp Ala Leu Ala Pro Gly Pro Phe Ala Ser Phe Pro Asn Gly Trp
1145 1150 1155
Thr Gly Lys Gln Lys Ser Pro Asp Gly Val His Arg Val Arg Val
1160 1165 1170
Asp Phe Lys Glu Asp Cys Asp Leu Glu Asn Val Trp Leu Met Gly
1175 1180 1185
Gly Leu Ser Val Leu Thr Ser Val Pro Gly Gly Pro Pro Met Val
1190 1195 1200
Cys Leu Leu Cys Ala Ser Lys Gly Leu His Glu Leu Val Phe Cys
1205 1210 1215
Gln Val Cys Cys Asp Pro Phe His Pro Phe Cys Leu Glu Glu Ala
1220 1225 1230
Glu Arg Pro Leu Pro Gln His His Asp Thr Trp Cys Cys Arg Arg
1235 1240 1245
Cys Lys Phe Cys His Val Cys Gly Arg Lys Gly Arg Gly Ser Lys
1250 1255 1260
His Leu Leu Glu Cys Glu Arg Cys Arg His Ala Tyr His Pro Ala
1265 1270 1275
Cys Leu Gly Pro Ser Tyr Pro Thr Arg Ala Thr Arg Lys Arg Arg
1280 1285 1290
His Trp Ile Cys Ser Ala Cys Val Arg Cys Lys Ser Cys Gly Ala
1295 1300 1305
Thr Pro Gly Lys Asn Trp Asp Val Glu Trp Ser Gly Asp Tyr Ser
1310 1315 1320
Leu Cys Pro Arg Cys Thr Gln Leu Tyr Glu Lys Gly Asn Tyr Cys
1325 1330 1335
Pro Ile Cys Thr Arg Cys Tyr Glu Asp Asn Asp Tyr Glu Ser Lys
1340 1345 1350
Met Met Gln Cys Ala Gln Cys Asp His Trp Val His Ala Lys Cys
1355 1360 1365
Glu Gly Leu Ser Asp Glu Asp Tyr Glu Ile Leu Ser Gly Leu Pro
1370 1375 1380
Asp Ser Val Leu Tyr Thr Cys Gly Pro Cys Ala Gly Ala Ala Gln
1385 1390 1395
Pro Arg Trp Arg Glu Ala Leu Ser Gly Ala Leu Gln Gly Gly Leu
1400 1405 1410
Arg Gln Val Leu Gln Gly Leu Leu Ser Ser Lys Val Val Gly Pro
1415 1420 1425
Leu Leu Leu Cys Thr Gln Cys Gly Pro Asp Gly Lys Gln Leu His
1430 1435 1440
Pro Gly Pro Cys Gly Leu Gln Ala Val Ser Gln Arg Phe Glu Asp
1445 1450 1455
Gly His Tyr Lys Ser Val His Ser Phe Met Glu Asp Met Val Gly
1460 1465 1470
Ile Leu Met Arg His Ser Glu Glu Gly Glu Thr Pro Asp Arg Arg
1475 1480 1485
Ala Gly Gly Gln Met Lys Gly Leu Leu Leu Lys Leu Leu Glu Ser
1490 1495 1500
Ala Phe Gly Trp Phe Asp Ala His Asp Pro Lys Tyr Trp Arg Arg
1505 1510 1515
Ser Thr Arg Leu Pro Asn Gly Val Leu Pro Asn Ala Val Leu Pro
1520 1525 1530
Pro Ser Leu Asp His Val Tyr Ala Gln Trp Arg Gln Gln Glu Pro
1535 1540 1545
Glu Thr Pro Glu Ser Gly Gln Pro Pro Gly Asp Pro Ser Ala Ala
1550 1555 1560
Phe Gln Gly Lys Asp Pro Ala Ala Phe Ser His Leu Glu Asp Pro
1565 1570 1575
Arg Gln Cys Ala Leu Cys Leu Lys Tyr Gly Asp Ala Asp Ser Lys
1580 1585 1590
Glu Ala Gly Arg Leu Leu Tyr Ile Gly Gln Asn Glu Trp Thr His
1595 1600 1605
Val Asn Cys Ala Ile Trp Ser Ala Glu Val Phe Glu Glu Asn Asp
1610 1615 1620
Gly Ser Leu Lys Asn Val His Ala Ala Val Ala Arg Gly Arg Gln
1625 1630 1635
Met Arg Cys Glu Leu Cys Leu Lys Pro Gly Ala Thr Val Gly Cys
1640 1645 1650
Cys Leu Ser Ser Cys Leu Ser Asn Phe His Phe Met Cys Ala Arg
1655 1660 1665
Ala Ser Tyr Cys Ile Phe Gln Asp Asp Lys Lys Val Phe Cys Gln
1670 1675 1680
Lys His Thr Asp Leu Leu Asp Gly Lys Glu Ile Val Asn Pro Asp
1685 1690 1695
Gly Phe Asp Val Leu Arg Arg Val Tyr Val Asp Phe Glu Gly Ile
1700 1705 1710
Asn Phe Lys Arg Lys Phe Leu Thr Gly Leu Glu Pro Asp Ala Ile
1715 1720 1725
Asn Val Leu Ile Gly Ser Ile Arg Ile Asp Ser Leu Gly Thr Leu
1730 1735 1740
Ser Asp Leu Ser Asp Cys Glu Gly Arg Leu Phe Pro Ile Gly Tyr
1745 1750 1755
Gln Cys Ser Arg Leu Tyr Trp Ser Thr Val Asp Ala Arg Arg Arg
1760 1765 1770
Cys Trp Tyr Arg Cys Arg Ile Leu Glu Tyr Arg Pro Trp Gly Pro
1775 1780 1785
Arg Glu Glu Pro Ala His Leu Glu Ala Ala Glu Glu Asn Gln Thr
1790 1795 1800
Ile Val His Ser Pro Ala Pro Ser Ser Glu Pro Pro Gly Gly Glu
1805 1810 1815
Asp Pro Pro Leu Asp Thr Asp Val Leu Val Pro Gly Ala Pro Glu
1820 1825 1830
Arg His Ser Pro Ile Gln Asn Leu Asp Pro Pro Leu Arg Pro Asp
1835 1840 1845
Ser Gly Ser Ala Pro Pro Pro Ala Pro Arg Ser Phe Ser Gly Ala
1850 1855 1860
Arg Ile Lys Val Pro Asn Tyr Ser Pro Ser Arg Arg Pro Leu Gly
1865 1870 1875
Gly Val Ser Phe Gly Pro Leu Pro Ser Pro Gly Ser Pro Ser Ser
1880 1885 1890
Leu Thr His His Ile Pro Thr Val Gly Asp Pro Asp Phe Pro Ala
1895 1900 1905
Pro Pro Arg Arg Ser Arg Arg Pro Ser Pro Leu Ala Pro Arg Pro
1910 1915 1920
Pro Pro Ser Arg Trp Ala Ser Pro Pro Leu Lys Thr Ser Pro Gln
1925 1930 1935
Leu Arg Val Pro Pro Pro Thr Ser Val Val Thr Ala Leu Thr Pro
1940 1945 1950
Thr Ser Gly Glu Leu Ala Pro Pro Gly Pro Ala Pro Ser Pro Pro
1955 1960 1965
Pro Pro Glu Asp Leu Gly Pro Asp Phe Glu Asp Met Glu Val Val
1970 1975 1980
Ser Gly Leu Ser Ala Ala Asp Leu Asp Phe Ala Ala Ser Leu Leu
1985 1990 1995
Gly Thr Glu Pro Phe Gln Glu Glu Ile Val Ala Ala Gly Ala Met
2000 2005 2010
Gly Ser Ser His Gly Gly Pro Gly Asp Ser Ser Glu Glu Glu Ser
2015 2020 2025
Ser Pro Thr Ser Arg Tyr Ile His Phe Pro Val Thr Val Val Ser
2030 2035 2040
Ala Pro Gly Leu Ala Pro Ser Ala Thr Pro Gly Ala Pro Arg Ile
2045 2050 2055
Glu Gln Leu Asp Gly Val Asp Asp Gly Thr Asp Ser Glu Ala Glu
2060 2065 2070
Ala Val Gln Gln Pro Arg Gly Gln Gly Thr Pro Pro Ser Gly Pro
2075 2080 2085
Gly Val Val Arg Ala Gly Val Leu Gly Ala Ala Gly Asp Arg Ala
2090 2095 2100
Arg Pro Pro Glu Asp Leu Pro Ser Glu Ile Val Asp Phe Val Leu
2105 2110 2115
Lys Asn Leu Gly Gly Pro Gly Asp Gly Gly Ala Gly Pro Arg Glu
2120 2125 2130
Glu Ser Leu Pro Pro Ala Pro Pro Leu Ala Asn Gly Ser Gln Pro
2135 2140 2145
Ser Gln Gly Leu Thr Ala Ser Pro Ala Asp Pro Thr Arg Thr Phe
2150 2155 2160
Ala Trp Leu Pro Gly Ala Pro Gly ValArg Val Leu Ser Leu Gly
2165 2170 2175
Pro Ala Pro Glu Pro Pro Lys Pro Ala Thr Ser Lys Ile Ile Leu
2180 2185 2190
Val Asn Lys Leu Gly Gln Val Phe Val Lys Met Ala Gly Glu Gly
2195 2200 2205
Glu Pro Val Pro Pro Pro Val Lys Gln Pro Pro Leu Pro Pro Thr
2210 2215 2220
Ile Ser Pro Thr Ala Pro Thr Ser Trp Thr Leu Pro Pro Gly Pro
2225 2230 2235
Leu Leu Gly Val Leu Pro Val Val Gly Val Val Arg Pro Ala Pro
2240 2245 2250
Pro Pro Pro Pro Pro Pro Leu Thr Leu Val Leu Ser Ser Gly Pro
2255 2260 2265
Ala Ser Pro Pro Arg Gln Ala Ile Arg Val Lys Arg Val Ser Thr
2270 2275 2280
Phe Ser Gly Arg Ser Pro Pro Ala Pro Pro Pro Tyr Lys Ala Pro
2285 2290 2295
Arg Leu Asp Glu Asp Gly Glu Ala Ser Glu Asp Thr Pro Gln Val
2300 2305 2310
Pro Gly Leu Gly Ser Gly Gly Phe Ser Arg Val Arg Met Lys Thr
2315 2320 2325
Pro Thr Val Arg Gly Val Leu Asp Leu Asp Arg Pro Gly Glu Pro
2330 2335 2340
Ala Gly Glu Glu Ser Pro Gly Pro Leu Gln Glu Arg Ser Pro Leu
2345 2350 2355
Leu Pro Leu Pro Glu Asp Gly Pro Pro Gln Val Pro Asp Gly Pro
2360 2365 2370
Pro Asp Leu Leu Leu Glu Ser Gln Trp His His Tyr Ser Gly Glu
2375 2380 2385
Ala Ser Ser Ser Glu Glu Glu Pro Pro Ser Pro Asp Asp Lys Glu
2390 2395 2400
Asn Gln Ala Pro Lys Arg Thr Gly Pro His Leu Arg Phe Glu Ile
2405 2410 2415
Ser Ser Glu Asp Gly Phe Ser Val Glu Ala Glu Ser Leu Glu Gly
2420 2425 2430
Ala Trp Arg Thr Leu Ile Glu Lys Val Gln Glu Ala Arg Gly His
2435 2440 2445
Ala Arg Leu Arg His Leu Ser Phe Ser Gly Met Ser Gly Ala Arg
2450 2455 2460
Leu Leu Gly Ile His His Asp Ala Val Ile Phe Leu Ala Glu Gln
2465 2470 2475
Leu Pro Gly Ala Gln Arg Cys Gln His Tyr Lys Phe Arg Tyr His
2480 2485 2490
Gln Gln Gly Glu Gly Gln Glu Glu Pro Pro Leu Asn Pro His Gly
2495 2500 2505
Ala Ala Arg Ala Glu Val Tyr Leu Arg Lys Cys Thr Phe Asp Met
2510 2515 2520
Phe Asn Phe Leu Ala Ser Gln His Arg Val Leu Pro Glu Gly Ala
2525 2530 2535
Thr Cys Asp Glu Glu Glu Asp Glu Val Gln Leu Arg Ser Thr Arg
2540 2545 2550
Arg Ala Thr Ser Leu Glu Leu Pro Met Ala Met Arg Phe Arg His
2555 2560 2565
Leu Lys Lys Thr Ser Lys Glu Ala Val Gly Val Tyr Arg Ser Ala
2570 2575 2580
Ile His Gly Arg Gly Leu Phe Cys Lys Arg Asn Ile Asp Ala Gly
2585 2590 2595
Glu Met Val Ile Glu Tyr Ser Gly Ile Val Ile Arg Ser Val Leu
2600 2605 2610
Thr Asp Lys Arg Glu Lys Phe Tyr Asp Gly Lys Gly Ile Gly Cys
2615 2620 2625
Tyr Met Phe Arg Met Asp Asp Phe Asp Val Val Asp Ala Thr Met
2630 2635 2640
His Gly Asn Ala Ala Arg Phe Ile Asn His Ser Cys Glu Pro Asn
2645 2650 2655
Cys Phe Ser Arg Val Ile His Val Glu Gly Gln Lys His Ile Val
2660 2665 2670
Ile Phe Ala Leu Arg Arg Ile Leu Arg Gly Glu Glu Leu Thr Tyr
2675 2680 2685
Asp Tyr Lys Phe Pro Ile Glu Asp Ala Ser Asn Lys Leu Pro Cys
2690 2695 2700
Asn Cys Gly Ala Lys Arg Cys Arg Arg Phe Leu Asn
2705 2710 2715
<210>107
<211>605
<212>PRT
<213>人
<400>107
Met Gln Cys Cys Gly Leu Val His Arg Arg Arg Val Arg Val Ser Tyr
1 5 10 15
Gly Ser Ala Asp Ser Tyr Thr Ser Arg Pro Ser Asp Ser Asp Val Ser
20 25 30
Leu Glu Glu Asp Arg Glu Ala Val Arg Arg Glu Ala Glu Arg Gln Ala
35 40 45
Gln Ala Gln Leu Glu Lys Ala Lys Thr Lys Pro Val Ala Phe Ala Val
50 55 60
Arg Thr Asn Val Ser Tyr Ser Ala Ala His Glu Asp Asp Val Pro Val
65 70 75 80
Pro Gly Met Ala Ile Ser Phe Glu Ala Lys Asp Phe Leu His Val Lys
85 90 95
Glu Lys Phe Asn Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu Gly
100 105 110
Cys Glu Ile Gly Phe Ile Pro Ser Pro Val Lys Leu Glu Asn Met Arg
115 120 125
Leu Gln His Glu Gln Arg Ala Lys Gln Gly Lys Phe Tyr Ser Ser Lys
130 135 140
Ser Gly Gly Asn Ser Ser Ser Ser Leu Gly Asp Ile Val Pro Ser Ser
145 150 155 160
Arg Lys Ser Thr Pro Pro Ser Ser Ala Ile Asp Ile Asp Ala Thr Gly
165 170 175
Leu Asp Ala Glu Glu Asn Asp Ile Pro Ala Asn His Arg Ser Pro Lys
180 185 190
Pro Ser Ala Asn Ser Val Thr Ser Pro His Ser Lys Glu Lys Arg Met
195 200 205
Pro Phe Phe Lys Lys Thr Glu His Thr Pro Pro Tyr Asp Val Val Pro
210 215 220
Ser Met Arg Pro Val Val Leu Val Gly Pro Ser Leu Lys Gly Tyr Glu
225 230 235 240
Val Thr Asp Met Met Gln Lys Ala Leu Phe Asp Phe Leu Lys His Arg
245 250 255
Phe Glu Gly Arg Ile Ser Ile Thr Arg Val Thr Ala Asp Ile Ser Leu
260 265 270
Ala Lys Arg Ser Val Leu Asn Asn Pro Ser Lys His Ala Ile Ile Glu
275 280 285
Arg Ser Asn Thr Arg Ser Ser Leu Ala Glu Val Gln Ser Glu Ile Glu
290 295 300
Arg Ile Phe Glu Leu Ala Arg Thr Leu Gln Leu Val Val Leu Asp Ala
305 310 315 320
Asp Thr Ile Asn His Pro Ala Gln Leu Ser Lys Thr Ser Leu Ala Pro
325 330 335
Ile Ile Val Tyr Val Lys Ile Ser Ser Pro Lys Val Leu Gln Arg Leu
340 345 350
Ile Lys Ser Arg Gly Lys Ser Gln Ala Lys His Leu Asn Val Gln Met
355 360 365
Val Ala Ala Asp Lys Leu Ala Gln Cys Pro Pro Glu Leu Phe Asp Val
370 375 380
lle Leu Asp Glu Asn Gln Leu Glu Asp Ala Cys Glu His Leu Ala Asp
385 390 395 400
Tyr Leu Glu Ala Tyr Trp Lys Ala Thr His Pro Pro Ser Ser Ser Leu
405 410 415
Pro Asn Pro Leu Leu Ser Arg Thr Leu Ala Thr Ser Ser Leu Pro Leu
420 425 430
Ser Pro Thr Leu Ala Ser Asn Ser Gln Gly Ser Gln Gly Asp Gln Arg
435 440 445
Thr Asp Arg Ser Ala Pro Ile Arg Ser Ala Ser Gln Ala Glu Glu Glu
450 455 460
Pro Ser Val Glu Pro Val Lys Lys Ser Gln His Arg Ser Ser Ser Ser
465 470 475 480
Ala Pro His His Asn His Arg Ser Gly Thr Ser Arg Gly Leu Ser Arg
485 490 495
Gln Glu Thr Phe Asp Ser Glu Thr Gln Glu Ser Arg Asp Ser Ala Tyr
500 505 510
Val Glu Pro Lys Glu Asp Tyr Ser His Asp His Val Asp His Tyr Ala
515 520 525
Ser His Arg Asp His Asn His Arg Asp Glu Thr His Gly Ser Ser Asp
530 535 540
His Arg His Arg Glu Ser Arg His Arg Ser Arg Asp Val Asp Arg Glu
545 550 555 560
Gln Asp His Asn Glu Cys Asn Lys Gln Arg Ser Arg His Lys Ser Lys
565 570 575
Asp Arg Tyr Cys Glu Lys Asp Gly Glu Val Ile Ser Lys Lys Arg Asn
580 585 590
Glu Ala Gly Glu Trp Asn Arg Asp Val Tyr Ile Pro Gln
595 600 605
<210>108
<211>562
<212>PRT
<213>人
<400>108
Met Ser Arg Val His Gly Met His Pro Lys Glu Thr Thr Arg Gln Leu
1 5 10 15
Ser Leu Ala Val Lys Asp Gly Leu Ile Val Glu Thr Leu Thr Val Gly
20 25 30
Cys Lys Gly Ser Lys Ala Gly Ile Glu Gln Glu Gly Tyr Trp Leu Pro
35 40 45
Gly Asp Glu Ile Asp Trp Glu Thr Glu Asn His Asp Trp Tyr Cys Phe
50 55 60
Glu Cys His Leu Pro Gly Glu Val Leu Ile Cys Asp Leu Cys Phe Arg
65 70 75 80
Val Tyr His Ser Lys Cys Leu Ser Asp Glu Phe Arg Leu Arg Asp Ser
85 90 95
Ser Ser Pro Trp Gln Cys Pro Val Cys Arg Ser Ile Lys Lys Lys Asn
100 105 110
Thr Asn Lys Gln Glu Met Gly Thr Tyr Leu Arg Phe Ile Val Ser Arg
115 120 125
Met Lys Glu Arg Ala Ile Asp Leu Asn Lys Lys Gly Lys Asp Asn Lys
130 135 140
His Pro Met Tyr Arg Arg Leu Val His Ser Ala Val Asp Val Pro Thr
145 150 155 160
Ile Gln Glu Lys Val Asn Glu Gly Lys Tyr Arg Ser Tyr Glu Glu Phe
165 170 175
Lys Ala Asp Ala Gln Leu Leu Leu His Asn Thr Val Ile Phe Tyr Gly
180 185 190
Ala Asp Ser Glu Gln Ala Asp Ile Ala Arg Met Leu Tyr Lys Asp Thr
195 200 205
Cys His Glu Leu Asp Glu Leu Gln Leu Cys Lys Asn Cys Phe Tyr Leu
210 215 220
Ser Asn Ala Arg Pro Asp Asn Trp Phe Cys Tyr Pro Cys Ile Pro Asn
225 230 235 240
His Glu Leu Val Trp Ala Lys Met Lys Gly Phe Gly Phe Trp Pro Ala
245 250 255
Lys Val Met Gln Lys Glu Asp Asn Gln Val Asp Val Arg Phe Phe Gly
260 265 270
His His His Gln Arg Ala Trp Ile Pro Ser Glu Asn Ile Gln Asp Ile
275 280 285
Thr Val Asn Ile His Arg Leu His Val Lys Arg Ser Met Gly Trp Lys
290 295 300
Lys Ala Cys Asp Glu Leu Glu Leu His Gln Arg Phe Leu Arg Glu Gly
305 310 315 320
Arg Phe Trp Lys Ser Lys Asn Glu Asp Arg Gly Glu Glu Glu Ala Glu
325 330 335
Ser Ser Ile Ser Ser Thr Ser Asn Glu Gln Leu Lys Val Thr Gln Glu
340 345 350
Pro Arg Ala Lys Lys Gly Arg Arg Asn Gln Ser Val Glu Pro Lys Lys
355 360 365
Glu Glu Pro Glu Pro Glu Thr Glu Ala Val Ser Ser Ser Gln Glu Ile
370 375 380
Pro Thr Met Pro Gln Pro Ile Glu Lys Val Ser Val Ser Thr Gln Thr
385 390 395 400
Lys Lys Leu Ser Ala Ser Ser Pro Arg Met Leu His Arg Ser Thr Gln
405 410 415
Thr Thr Asn Asp Gly Val Cys Gln Ser Met Cys His Asp Lys Tyr Thr
420 425 430
Lys Ile Phe Asn Asp Phe Lys Asp Arg Met Lys Ser Asp His Lys Arg
435 440 445
Glu Thr Glu Arg Val ValArg Glu Ala Leu Glu Lys Leu Arg Ser Glu
450 455 460
Met Glu Glu Glu Lys Arg Gln Ala Val Asn Lys Ala Val Ala Asn Met
465 470 475 480
Gln Gly Glu Met Asp Arg Lys Cys Lys Gln ValLys Glu Lys Cys Lys
485 490 495
Glu Glu Phe Val Glu Glu Ile Lys Lys Leu Ala Thr Gln His Lys Gln
500 505 510
Leu Ile Ser Gln Thr Lys Lys Lys Gln Trp Cys Tyr Asn Cys Glu Glu
515 520 525
Glu Ala Met Tyr His Cys Cys Trp Asn Thr Ser Tyr Cys Ser Ile Lys
530 535 540
Cys Gln Gln Glu His Trp His Ala Glu His Lys Arg Thr Cys Arg Arg
545 550 555 560
Lys Arg
<210>109
<211>2145
<212>PRT
<213>人
<400>109
Met Ser Asp Arg Ser Gly Pro Thr Ala Lys Gly Lys Asp Gly Lys Lys
1 5 10 15
Tyr Ser Ser Leu Asn Leu Phe Asp Thr Tyr Lys Gly Lys Ser Leu Glu
20 25 30
Ile Gln Lys Pro Ala Val Ala Pro Arg His Gly Leu Gln Ser Leu Gly
35 40 45
Lys Val Ala Ile Ala Arg Arg Met Pro Pro Pro Ala Asn Leu Pro Ser
50 55 60
Leu Lys Ala Glu Asn Lys Gly Asn Asp Pro Asn Val Ser Leu Val Pro
65 70 75 80
Lys Asp Gly Thr Gly Trp Ala Ser Lys Gln Glu Gln Ser Asp Pro Lys
85 90 95
Ser Ser Asp Ala Ser Thr Ala Gln Pro Pro Glu Ser Gln Pro Leu Pro
100 105 110
Ala Ser Gln Thr Pro Ala Ser Asn Gln Pro Lys Arg Pro Pro Ala Ala
115 120 125
Pro Glu Asn Thr Pro Leu Val Pro Ser Gly Val Lys Ser Trp Ala Gln
130 135 140
Ala Ser Val Thr His Gly Ala His Gly Asp Gly Gly Arg Ala Ser Ser
145 150 155 160
Leu Leu Ser Arg Phe Ser Arg Glu Glu Phe Pro Thr Leu Gln Ala Ala
165 170 175
Gly Asp Gln Asp Lys Ala Ala Lys Glu Arg Glu Ser Ala Glu Gln Ser
180 185 190
Ser Gly Pro Gly Pro Ser Leu Arg Pro Gln Asn Ser Thr Thr Trp Arg
195 200 205
Asp Gly Gly Gly Arg Gly Pro Asp Glu Leu Glu Gly Pro Asp Ser Lys
210 215 220
Leu His His Gly His Asp Pro Arg Gly Gly Leu Gln Pro Ser Gly Pro
225 230 235 240
Pro Gln Phe Pro Pro Tyr Arg Gly Met Met Pro Pro Phe Met Tyr Pro
245 250 255
Pro Tyr Leu Pro Phe Pro Pro Pro Tyr Gly Pro Gln Gly Pro Tyr Arg
260 265 270
Tyr Pro Thr Pro Asp Gly Pro Ser Arg Phe Pro Arg Val Ala Gly Pro
275 280 285
Arg Gly Ser Gly Pro Pro Met Arg Leu Val Glu Pro Val Gly Arg Pro
290 295 300
Ser Ile Leu Lys Glu Asp Asn Leu Lys Glu Phe Asp Gln Leu Asp Gln
305 310 315 320
Glu Asn Asp Asp Gly Trp Ala Gly Ala His Glu Glu Val Asp Tyr Thr
325 330 335
Glu Lys Leu Lys Phe Ser Asp Glu Glu Asp Gly Arg Asp Ser Asp Glu
340 345 350
Glu Gly Ala Glu Gly His Arg Asp Ser Gln Ser Ala Ser Gly Glu Glu
355 360 365
Arg Pro Pro Glu Ala Asp Gly Lys Lys Gly Asn Ser Pro Asn Ser Glu
370 375 380
Pro Pro Thr Pro Lys Thr Ala Trp Ala Glu Thr Ser Arg Pro Pro Glu
385 390 395 400
Thr Glu Pro Gly Pro Pro Ala Pro Lys Pro Pro Leu Pro Pro Gly Asp
405 410 415
Tyr Pro Asp Arg Gly Gly Pro Pro Cys Lys Pro Pro Ala Pro Glu Asp
420 425 430
Glu Asp Glu Ala Trp Arg Gln Arg Arg Lys Gln Ser Ser Ser Glu Ile
435 440 445
Ser Leu Ala Val Glu Arg Ala Arg Arg Arg Arg Glu Glu Glu Glu Arg
450 455 460
Arg Met Gln Glu Glu Arg Arg Ala Ala Cys Ala Glu Lys Leu Lys Arg
465 470 475 480
Leu Asp Glu Lys Phe Gly Ala Pro Asp Lys Arg Leu Lys Ala Glu Pro
485 490 495
Ala Ala Pro Pro Ala Ala Pro Ser Thr Pro Ala Pro Pro Pro Ala Val
500 505 510
Pro Lys Glu Leu Pro Ala Pro Pro Ala Pro Pro Pro Ala Ser Ala Pro
515 520 525
Thr Pro Glu Lys Glu Pro Glu Glu Pro Ala Gln Ala Pro Pro Ala Gln
530 535 540
Ser Thr Pro Thr Pro Gly Val Ala Ala Ala Pro Thr Leu Val Ser Gly
545 550 555 560
Gly Gly Ser Thr Ser Ser Thr Ser Ser Gly Ser Phe Glu Ala Ser Pro
565 570 575
Val Glu Pro Gln Leu Pro Ser Lys Glu Gly Pro Glu Pro Pro Glu Glu
580 585 590
Val Pro Pro Pro Thr Thr Pro Pro Val Pro Lys Val Glu Pro Lys Gly
595 600 605
Asp Gly Ile Gly Pro Thr Arg Gln Pro Pro Ser Gln Gly Leu Gly Tyr
610 615 620
Pro Lys Tyr Gln Lys Ser Leu Pro Pro Arg Phe Gln Arg Gln Gln Gln
625 630 635 640
Glu Gln Leu Leu Lys Gln Gln Gln Gln His Gln Trp Gln Gln His Gln
645 650 655
Gln Gly Ser Ala Pro Pro Thr Pro Val Pro Pro Ser Pro Pro Gln Pro
660 665 670
Val Thr Leu Gly Ala Val Pro Ala Pro Gln Ala Pro Pro Pro Pro Pro
675 680 685
Lys Ala Leu Tyr Pro Gly Ala Leu Gly Arg Pro Pro Pro Met Pro Pro
690 695 700
Met Asn Phe Asp Pro Arg Trp Met Met Ile Pro Pro Tyr Val Asp Pro
705 710 715 720
Arg Leu Leu Gln Gly Arg Pro Pro Leu Asp Phe Tyr Pro Pro Gly Val
725 730 735
His Pro Ser Gly Leu Val Pro Arg Glu Arg Ser Asp Ser Gly Gly Ser
740 745 750
Ser Ser Glu Pro Phe Asp Arg His Ala Pro Ala Met Leu Arg Glu Arg
755 760 765
Gly Thr Pro Pro Val Asp Pro Lys Leu Ala Trp Val Gly Asp Val Phe
770 775 780
Thr Ala Thr Pro Ala Glu Pro Arg Pro Leu Thr Ser Pro Leu Arg Gln
785 790 795 800
Ala Ala Asp Glu Asp Asp Lys Gly Met Arg Ser Glu Thr Pro Pro Val
805 810 815
Pro Pro Pro Pro Pro Tyr Leu Ala Ser Tyr Pro Gly Phe Pro Glu Asn
820 825 830
Gly Ala Pro Gly Pro Pro Ile Ser Arg Phe Pro Leu Glu Glu Pro Gly
835 840 845
Pro Arg Pro Leu Pro Trp Pro Pro Gly Ser Asp Glu Val Ala Lys Ile
850 855 860
Gln Thr Pro Pro Pro Lys Lys Glu Pro Pro Lys Glu Glu Thr Ala Gln
865 870 875 880
Leu Thr Gly Pro Glu Ala Gly Arg Lys Pro Ala Arg Gly Val Gly Ser
885 890 895
Gly Gly Gln Gly Pro Pro Pro Pro Arg Arg Glu Ser Arg Thr Glu Thr
900 905 910
Arg Trp Gly Pro Arg Pro Gly Ser Ser Arg Arg Gly Ile Pro Pro Glu
915 920 925
Glu Pro Gly Ala Pro Pro Arg Arg Ala Gly Pro Ile Lys Lys Pro Pro
930 935 940
Pro Pro Thr Lys Val Glu Glu Leu Pro Pro Lys Pro Leu Glu Gln Gly
945 950 955 960
Asp Glu Thr Pro Lys Pro Pro Lys Pro Asp Pro Leu Lys Ile Thr Lys
965 970 975
Gly Lys Leu Gly Gly Pro Lys Glu Thr Pro Pro Asn Gly Asn Leu Ser
980 985 990
Pro Ala Pro Arg Leu Arg Arg Asp Tyr Ser Tyr Glu Arg Val Gly Pro
995 1000 1005
Thr Ser Cys Arg Gly Arg Gly Arg Gly Glu Tyr Phe Ala Arg Gly
1010 1015 1020
Arg Gly Phe Arg Gly Thr Tyr Gly Gly Arg Gly Arg Gly Ala Arg
1025 1030 1035
Ser Arg Glu Phe Arg Ser Tyr Arg Glu Phe Arg Gly Asp Asp Gly
1040 1045 1050
Arg Gly Gly Gly Thr Gly Gly Pro Asn His Pro Pro Ala Pro Arg
1055 1060 1065
Gly Arg Thr Ala Ser Glu Thr Arg Ser Glu Gly Ser Glu Tyr Glu
1070 1075 1080
Glu Ile Pro Lys Arg Arg Arg Gln Arg Gly Ser Glu Thr Gly Ser
1085 1090 1095
Glu Thr His Glu Ser Asp Leu Ala Pro Ser Asp Lys Glu Ala Pro
1100 1105 1110
Thr Pro Lys Glu Gly Thr Leu Thr Gln Val Pro Leu Ala Pro Pro
1115 1120 1125
Pro Pro Gly Ala Pro Pro Ser Pro Ala Pro Ala Arg Phe Thr Ala
1130 1135 1140
Arg Gly Gly Arg Val Phe Thr Pro Arg Gly Val Pro Ser Arg Arg
1145 1150 1155
Gly Arg Gly Gly Gly Arg Pro Pro Pro Gln Val Cys Pro Gly Trp
1160 1165 1170
Ser Pro Pro Ala Lys Ser Leu Ala Pro Lys Lys Pro Pro Thr Gly
1175 1180 1185
Pro Leu Pro Pro Ser Lys Glu Pro Leu Lys Glu Lys Leu Ile Pro
1190 1195 1200
Gly Pro Leu Ser Pro Val Ala Arg Gly Gly Ser Asn Gly Gly Ser
1205 1210 1215
Asn Val Gly Met Glu Asp Gly Glu Arg Pro Arg Arg Arg Arg His
1220 1225 1230
Gly Arg Ala Gln Gln Gln Asp Lys Pro Pro Arg Phe Arg Arg Leu
1235 1240 1245
Lys Gln Glu Arg Glu Asn Ala Ala Arg Gly Ser Glu Gly Lys Pro
1250 1255 1260
Ser Leu Thr Leu Pro Ala Ser Ala Pro Ala Pro Glu Glu Ala Leu
1265 1270 1275
Thr Thr Val Thr Val Ala Pro Ala Pro Arg Arg Ala Ala Ala Lys
1280 1285 1290
Ser Pro Asp Leu Ser Asn Gln Asn Ser Asp Gln Ala Asn Glu Glu
1295 1300 1305
Trp Glu Thr Ala Ser Glu Ser Ser Asp Phe Thr Ser Glu Arg Arg
1310 1315 1320
Gly Asp Lys Glu Ala Pro Pro Pro Val Leu Leu Thr Pro Lys Ala
1325 1330 1335
Val Gly Thr Pro Gly Gly Gly Gly Gly Gly Ala Val Pro Gly Ile
1340 1345 1350
Ser Ala Met Ser Arg Gly Asp Leu Ser Gln Arg Ala Lys Asp Leu
1355 1360 1365
Ser Lys Arg Ser Phe Ser Ser Gln Arg Pro Gly Met Glu Arg Gln
1370 1375 1380
Asn Arg Arg Pro Gly Pro Gly Gly Lys Ala Gly Ser Ser Gly Ser
1385 1390 1395
Ser Ser Gly Gly Gly Gly Gly Gly Pro Gly Gly Arg Thr Gly Pro
1400 1405 1410
Gly Arg Gly Asp Lys Arg Ser Trp Pro Ser Pro Lys Asn Arg Ser
1415 1420 1425
Arg Pro Pro Glu Glu Arg Pro Pro Gly Leu Pro Leu Pro Pro Pro
1430 1435 1440
Pro Pro Ser Ser Ser Ala Val Phe Arg Leu Asp Gln Val Ile His
1445 1450 1455
Ser Asn Pro Ala Gly Ile Gln Gln Ala Leu Ala Gln Leu Ser Ser
1460 1465 1470
Arg Gln Gly Ser Val Thr Ala Pro Gly Gly His Pro Arg His Lys
1475 1480 1485
Pro Gly Pro Pro Gln Ala Pro Gln Gly Pro Ser Pro Arg Pro Pro
1490 1495 1500
Thr Arg Tyr Glu Pro Gln Arg Val Asn Ser Gly Leu Ser Ser Asp
1505 1510 1515
Pro His Phe Glu Glu Pro Gly Pro Met Val Arg Gly Val Gly Gly
1520 1525 1530
Thr Pro Arg Asp Ser Ala Gly Val Ser Pro Phe Pro Pro Lys Arg
1535 1540 1545
Arg Glu Arg Pro Pro Arg Lys Pro Glu Leu Leu Gln Glu Glu Ser
1550 1555 1560
Leu Pro Pro Pro His Ser Ser Gly Phe Leu Gly Ser Lys Pro Glu
1565 1570 1575
Gly Pro Gly Pro Gln Ala Glu Ser Arg Asp Thr Gly Thr Glu Ala
1580 1585 1590
Leu Thr Pro His Ile Trp Asn Arg Leu His Thr Ala Thr Ser Arg
1595 1600 1605
Lys Ser Tyr Arg Pro Ser Ser Met Glu Pro Trp Met Glu Pro Leu
1610 1615 1620
Ser Pro Phe Glu Asp Val Ala Gly Thr Glu Met Ser Gln Ser Asp
1625 1630 1635
Ser Gly Val Asp Leu Ser Gly Asp Ser Gln Val Ser Ser Gly Pro
1640 1645 1650
Cys Ser Gln Arg Ser Ser Pro Asp Gly Gly Leu Lys Gly Ala Ala
1655 1660 1665
Glu Gly Pro Pro Lys Arg Pro Gly Gly Ser Ser Pro Leu Asn Ala
1670 1675 1680
Val Pro Cys Glu Gly Pro Pro Gly Ser Glu Pro Pro Arg Arg Pro
1685 1690 1695
Pro Pro Ala Pro His Asp Gly Asp Arg Lys Glu Leu Pro Arg Glu
1700 1705 1710
Gln Pro Leu Pro Pro Gly Pro Ile Gly Thr Glu Arg Ser Gln His
1715 1720 1725
Thr Asp Arg Gly Thr Glu Pro Gly Pro Ile Arg Pro Ser His Arg
1730 1735 1740
Pro Gly Pro Pro Val Gln Phe Gly Thr Ser Asp Lys Asp Ser Asp
1745 1750 1755
Leu Arg Leu Val Val Gly Asp Ser Leu Lys Ala Glu Lys Glu Leu
1760 1765 1770
Thr Ala Ser Val Thr Glu Ala Ile Pro Val Ser Arg Asp Trp Glu
1775 1780 1785
Leu Leu Pro Ser Ala Ala Ala Ser Ala Glu Pro Gln Ser Lys Asn
1790 1795 1800
Leu Asp Ser Gly His Cys Val Pro Glu Pro Ser Ser Ser Gly Gln
1805 1810 1815
Arg Leu Tyr Pro Glu Val Phe Tyr Gly Ser Ala Gly Pro Ser Ser
1820 1825 1830
Ser Gln Ile Ser Gly Gly Ala Met Asp Ser Gln Leu His Pro Asn
1835 1840 1845
Ser Gly Gly Phe Arg Pro Gly Thr Pro Ser Leu His Pro Tyr Arg
1850 1855 1860
Ser Gln Pro Leu Tyr Leu Pro Pro Gly Pro Ala Pro Pro Ser Ala
1865 1870 1875
Leu Leu Ser Gly Val Ala Leu Lys Gly Gln Phe Leu Asp Phe Ser
1880 1885 1890
Thr Met Gln Ala Thr Glu Leu Gly Lys Leu Pro Ala Gly Gly Val
1895 1900 1905
Leu Tyr Pro Pro Pro Ser Phe Leu Tyr Ser Pro Ala Phe Cys Pro
1910 1915 1920
Ser Pro Leu Pro Asp Thr Ser Leu Leu Gln Val Arg Gln Asp Leu
1925 1930 1935
Pro Ser Pro Ser Asp Phe Tyr Ser Thr Pro Leu Gln Pro Gly Gly
1940 1945 1950
Gln Ser Gly Phe Leu Pro Ser Gly Ala Pro Ala Gln Gln Met Leu
1955 1960 1965
Leu Pro Met Val Asp Ser Gln Leu Pro Val Val Asn Phe Gly Ser
1970 1975 1980
Leu Pro Pro Ala Pro Pro Pro Ala Pro Pro Pro Leu Ser Leu Leu
1985 1990 1995
Pro Val Gly Pro Ala Leu Gln Pro Pro Ser Leu Ala Val Arg Pro
2000 2005 2010
Pro Pro Ala Pro Ala Thr Arg Val Leu Pro Ser Pro Ala Arg Pro
2015 2020 2025
Phe Pro Ala Ser Leu Gly Arg Ala Glu Leu His Pro Val Glu Leu
2030 2035 2040
Lys Pro Phe Gln Asp Tyr Gln Lys Leu Ser Ser Asn Leu Gly Gly
2045 2050 2055
Pro Gly Ser Ser Arg Thr Pro Pro Thr Gly Arg Ser Phe Ser Gly
2060 2065 2070
Leu Asn Ser Arg Leu Lys Ala Thr Pro Ser Thr Tyr Ser Gly Val
2075 2080 2085
Phe Arg Thr Gln Arg Val Asp Leu Tyr Gln Gln Ala Ser Pro Pro
2090 2095 2100
Asp Ala Leu Arg Trp Ile Pro Lys Pro Trp Glu Arg Thr Gly Leu
2105 2110 2115
Pro Pro Arg Glu Gly Pro Ser Arg Arg Ala Glu Glu Pro Gly Ser
2120 2125 2130
Arg Gly Asp Lys Glu Pro Gly Leu Pro Pro Pro Arg
2135 2140 2145
<210>110
<211>535
<212>PRT
<213>人
<400>110
Met Ser Glu Gly Glu Ser Gln Thr Val Leu Ser Ser Gly Ser Asp Pro
1 5 10 15
Lys Val Glu Ser Ser Ser Ser Ala Pro Gly Leu Thr Ser Val Ser Pro
20 25 30
Pro Val Thr Ser Thr Thr Ser Ala Ala Ser Pro Glu Glu Glu Glu Glu
35 40 45
Ser Glu Asp Glu Ser Glu Ile Leu Glu Glu Ser Pro Cys Gly Arg Trp
50 55 60
Gln Lys Arg Arg Glu Glu Val Asn Gln Arg Asn Val Pro Gly Ile Asp
65 70 75 80
Ser Ala Tyr Leu Ala Met Asp Thr Glu Glu Gly Val Glu Val Val Trp
85 90 95
Asn Glu Val Gln Phe Ser Glu Arg Lys Asn Tyr Lys Leu Gln Glu Glu
100 105 110
Lys Val Arg Ala Val Phe Asp Asn Leu Ile Gln Leu Glu His Leu Asn
115 120 125
Ile Val Lys Phe His Lys Tyr Trp Ala Asp Ile Lys Glu Asn Lys Ala
130 135 140
Arg Val Ile Phe Ile Thr Glu Tyr Met Ser Ser Gly Ser Leu Lys Gln
145 150 155 160
Phe Leu Lys Lys Thr Lys Lys Asn His Lys Thr Met Asn Glu Lys Ala
165 170 175
Trp Lys Arg Trp Cys Thr Gln Ile Leu Ser Ala Leu Ser Tyr Leu His
180 185 190
Ser Cys Asp Pro Pro Ile Ile His Gly Asn Leu Thr Cys Asp Thr Ile
195 200 205
Phe Ile Gln His Asn Gly Leu Ile Lys Ile Gly Ser Val Ala Pro Asp
210 215 220
Thr Ile Asn Asn His Val Lys Thr Cys Arg Glu Glu Gln Lys Asn Leu
225 230 235 240
His Phe Phe Ala Pro Glu Tyr Gly Glu Val Thr Asn Val Thr Thr Ala
245 250 255
Val Asp Ile Tyr Ser Phe Gly Met Cys Ala Leu Glu Met Ala Val Leu
260 265 270
Glu Ile Gln Gly Asn Gly Glu Ser Ser Tyr Val Pro Gln Glu Ala Ile
275 280 285
Ser Ser Ala Ile Gln Leu Leu Glu Asp Pro Leu Gln Arg Glu Phe Ile
290 295 300
Gln Lys Cys Leu Gln Ser Glu Pro Ala Arg Arg Pro Thr Ala Arg Glu
305 310 315 320
Leu Leu Phe His Pro Ala Leu Phe Glu Val Pro Ser Leu Lys Leu Leu
325 330 335
Ala Ala His Cys Ile Val Gly His Gln His Met Ile Pro Glu Asn Ala
340 345 350
Leu Glu Glu Ile Thr Lys Asn Met Asp Thr Ser Ala Val Leu Ala Glu
355 360 365
Ile Pro Ala Gly Pro Gly Arg Glu Pro Val Gln Thr Leu Tyr Ser Gln
370 375 380
Ser Pro Ala Leu Glu Leu Asp Lys Phe Leu Glu Asp Val Arg Asn Gly
385 390 395 400
Ile Tyr Pro Leu Thr Ala Phe Gly Leu Pro Arg Pro Gln Gln Pro Gln
405 410 415
Gln Glu Glu Val Thr Ser Pro Val Val Pro Pro Ser Val Lys Thr Pro
420 425 430
Thr Pro Glu Pro Ala Glu Val Glu Thr Arg Lys Val Val Leu Met Gln
435 440 445
Cys Asn Ile Glu Ser Val Glu Glu Gly Val Lys His His Leu Thr Leu
450 455 460
Leu Leu Lys Leu Glu Asp Lys Leu Asn Arg His Leu Ser Cys Asp Leu
465 470 475 480
Met Pro Asn Glu Asn Ile Pro Glu Leu Ala Ala Glu Leu Val Gln Leu
485 490 495
Gly Phe Ile Ser Glu Ala Asp Gln Ser Arg Leu Thr Ser Leu Leu Glu
500 505 510
Glu Thr Leu Asn Lys Phe Asn Phe Ala Arg Asn Ser Thr Leu Asn Ser
515 520 525
Ala Ala Val Thr Val Ser Ser
530 535
<210>111
<211>1980
<212>PRT
<213>人
<400>111
Met Asn Pro Thr Asn Pro Phe Ser Gly Gln Gln Pro Ser Ala Phe Ser
1 5 10 15
Ala Ser Ser Ser Asn Val Gly Thr Leu Pro Ser Lys Pro Pro Phe Arg
20 25 30
Phe Gly Gln Pro Ser Leu Phe Gly Gln Asn Ser Thr Leu Ser Gly Lys
35 40 45
Ser Ser Gly Phe Ser Gln Val Ser Ser Phe Pro Ala Ser Ser Gly Val
50 55 60
Ser His Ser Ser Ser Val Gln Thr Leu Gly Phe Thr Gln Thr Ser Ser
65 70 75 80
ValGly Pro Phe Ser Gly Leu Glu His Thr Ser Thr Phe Val Ala Thr
85 90 95
Ser Gly Pro Ser Ser Ser Ser Val Leu Gly Asn Thr Gly Phe Ser Phe
100 105 110
Lys Ser Pro Thr Ser Val Gly Ala Phe Pro Ser Thr Ser Ala Phe Gly
115 120 125
Gln Glu Ala Gly Glu Ile Val Asn Ser Gly Phe Gly Lys Thr Glu Phe
130 135 140
Ser Phe Lys Pro Leu Glu Asn Ala Val Phe Lys Pro Ile Leu Gly Ala
145 150 155 160
Glu Ser Glu Pro Glu Lys Thr Gln Ser Gln Ile Ala Ser Gly Phe Phe
165 170 175
Thr Phe Ser His Pro Ile Ser Ser Ala Pro Gly Gly Leu Ala Pro Phe
180 185 190
Ser Phe Pro Gln Val Thr Ser Ser Ser Ala Thr Thr Ser Asn Phe Thr
195 200 205
Phe Ser Lys Pro Val Ser Ser Asn Asn Ser Leu Ser Ala Phe Thr Pro
210 215 220
Ala Leu Ser Asn Gln Asn Val Glu Glu Glu Lys Arg Gly Pro Lys Ser
225 230 235 240
Ile Phe Gly Ser Ser Asn Asn Ser Phe Ser Ser Phe Pro Val Ser Ser
245 250 255
Ala Val Leu Gly Glu Pro Phe Gln Ala Ser Lys Ala Gly Val Arg Gln
260 265 270
Gly Cys Glu Glu Ala Val Ser Gln Val Glu Pro Leu Pro Ser Leu Met
275 280 285
Lys Gly Leu Lys Arg Lys Glu Asp Gln Asp Arg Ser Pro Arg Arg His
290 295 300
Gly His Glu Pro Ala Glu Asp Ser Asp Pro Leu Ser Arg Gly Asp His
305 310 315 320
Pro Pro Asp Lys Arg Pro Val Arg Leu Asn Arg Pro Arg Gly Gly Thr
325 330 335
Leu Phe Gly Arg Thr Ile Gln Asp Val Phe Lys Ser Asn Lys Glu Val
340 345 350
Gly Arg Leu Gly Asn Lys Glu Ala Lys Lys Glu Thr Gly Phe Val Glu
355 360 365
Ser Ala Glu Ser Asp His Met Ala Ile Pro Gly Gly Asn Gln Ser Val
370 375 380
Leu Ala Pro Ser Arg Ile Pro Gly Val Asn Lys Glu Glu Glu Thr Glu
385 390 395 400
Ser Arg Glu Lys Lys Glu Asp Ser Leu Arg Gly Thr Pro Ala Arg Gln
405 410 415
Ser Asn Arg Ser Glu Ser Thr Asp Ser Leu Gly Gly Leu Ser Pro Ser
420 425 430
Glu Val Thr Ala Ile Gln Cys Lys Asn Ile Pro Asp Tyr Leu Asn Asp
435 440 445
Arg Thr Ile Leu Glu Asn His Phe Gly Lys Ile Ala Lys Val Gln Arg
450 455 460
Ile Phe Thr Arg Arg Ser Lys Lys Leu Ala Val Val His Phe Phe Asp
465 470 475 480
His Ala Ser Ala Ala Leu Ala Arg Lys Lys Gly Lys Ser Leu His Lys
485 490 495
Asp Met Ala Ile Phe Trp His Arg Lys Lys Ile Ser Pro Asn Lys Lys
500 505 510
Pro Phe Ser Leu Lys Glu Lys Lys Pro Gly Asp Gly Glu Val Ser Pro
515 520 525
Ser Thr Glu Asp Ala Pro Phe Gln His Ser Pro Leu Gly Lys Ala Ala
530 535 540
Gly Arg Thr Gly Ala Ser Ser Leu Leu Asn Lys Ser Ser Pro Val Lys
545 550 555 560
Lys Pro Ser Leu Leu Lys Ala His Gln Phe Glu Gly Asp Ser Phe Asp
565 570 575
Ser Ala Ser Glu Gly Ser Glu Gly Leu Gly Pro Cys Val Leu Ser Leu
580 585 590
Ser Thr Leu Ile Gly Thr Val Ala Glu Thr Ser Lys Glu Lys Tyr Arg
595 600 605
Leu Leu Asp Gln Arg Asp Arg Ile Met Arg Gln Ala Arg Val Lys Arg
610 615 620
Thr Asp Leu Asp Lys Ala Arg Thr Phe Val Gly Thr Cys Leu Asp Met
625 630 635 640
Cys Pro Glu Lys Glu Arg Tyr Met Arg Glu Thr Arg Ser Gln Leu Ser
645 650 655
Val Phe Glu Val Val Pro Gly Thr Asp Gln Val Asp His Ala Ala Ala
660 665 670
Val Lys Glu Tyr Ser Arg Ser Ser Ala Asp Gln Glu Glu Pro Leu Pro
675 680 685
His Glu Leu Arg Pro Leu Pro Val Leu Ser Arg Thr Met Asp Tyr Leu
690 695 700
Val Thr Gln Ile Met Asp Gln Lys Glu Gly Ser Leu Arg Asp Trp Tyr
705 710 715 720
Asp Phe Val Trp Asn Arg Thr Arg Gly Ile Arg Lys Asp Ile Thr Gln
725 730 735
Gln His Leu Cys Asp Pro Leu Thr Val Ser Leu Ile Glu Lys Cys Thr
740 745 750
Arg Phe His Ile His Cys Ala His Phe Met Cys Glu Glu Pro Met Ser
755 760 765
Ser Phe Asp Ala Lys Ile Asn Asn Glu Asn Met Thr Lys Cys Leu Gln
770 775 780
Ser Leu Lys Glu Met Tyr Gln Asp Leu Arg Asn Lys Gly Val Phe Cys
785 790 795 800
Ala Ser Glu Ala Glu Phe Gln Gly Tyr Asn Val Leu Leu Ser Leu Asn
805 810 815
Lys Gly Asp Ile Leu Arg Glu Val Gln Gln Phe His Pro Ala Val Arg
820 825 830
Asn Ser Ser Glu Val Lys Phe Ala Val Gln Ala Phe Ala Ala Leu Asn
835 840 845
Ser Asn Asn Phe Val Arg Phe Phe Lys Leu Val Gln Ser Ala Ser Tyr
850 855 860
Leu Asn Ala Cys Leu Leu His Cys Tyr Phe Ser Gln Ile Arg Lys Asp
865 870 875 880
Ala Leu Arg Ala Leu Asn Phe Ala Tyr Thr Val Ser Thr Gln Arg Ser
885 890 895
Thr Ile Phe Pro Leu Asp Gly Val Val Arg Met Leu Leu Phe Arg Asp
900 905 910
Cys Glu Glu Ala Thr Asp Phe Leu Thr Cys His Gly Leu Thr Val Ser
915 920 925
Asp Gly Cys Val Glu Leu Asn Arg Ser Ala Phe Leu Glu Pro Glu Gly
930 935 940
Leu Ser Lys Thr Arg Lys Ser Val Phe Ile Thr Arg Lys Leu Thr Val
945 950 955 960
Ser Val Gly Glu Ile Val Asn Gly Gly Pro Leu Pro Pro Val Pro Arg
965 970 975
His Thr Pro Val Cys Ser Phe Asn Ser Gln Asn Lys Tyr Ile Gly Glu
980 985 990
Ser Leu Ala Ala Glu Leu Pro Val Ser Thr Gln Arg Pro Gly Ser Asp
995 1000 1005
Thr Val Gly Gly Gly Arg Gly Glu Glu Cys Gly Val Glu Pro Asp
1010 1015 1020
Ala Pro Leu Ser Ser Leu Pro Gln Ser Leu Pro Ala Pro Ala Pro
1025 1030 1035
Ser Pro Val Pro Leu Pro Pro Val Leu Ala Leu Thr Pro Ser Val
1040 1045 1050
Ala Pro Ser Leu Phe Gln Leu Ser Val Gln Pro Glu Pro Pro Pro
1055 1060 1065
Pro Glu Pro Val Pro Met Tyr Ser Asp Glu Asp Leu Ala Gln Val
1070 1075 1080
Val Asp Glu Leu Ile Gln Glu Ala Leu Gln Arg Asp Cys Glu Glu
1085 1090 1095
Val Gly Ser Ala Gly Ala Ala Tyr Ala Ala Ala Ala Leu Gly Val
1100 1105 1110
Ser Asn Ala Ala Met Glu Asp Leu Leu Thr Ala Ala Thr Thr Gly
1115 1120 1125
Ile Leu Arg His Ile Ala Ala Glu Glu Val Ser Lys Glu Arg Glu
1130 1135 1140
Arg Arg Glu Gln Glu Arg Gln Arg Ala Glu Glu Glu Arg Leu Lys
1145 1150 1155
Gln Glu Arg Glu Leu Val Leu Ser Glu Leu Ser Gln Gly Leu Ala
1160 1165 1170
Val Glu Leu Met Glu Arg Val Met Met Glu Phe Val Arg Glu Thr
1175 1180 1185
Cys Ser Gln Glu Leu Lys Asn Ala Val Glu Thr Asp Gln Arg Val
1190 1195 1200
Arg Val Ala Arg Cys Cys Glu Asp Val Cys Ala His Leu Val Asp
1205 1210 1215
Leu Phe Leu Val Glu Glu Ile Phe Gln Thr Ala Lys Glu Thr Leu
1220 1225 1230
Gln Glu Leu Gln Cys Phe Cys Lys Tyr Leu Gln Arg Trp Arg Glu
1235 1240 1245
Ala Val Thr Ala Arg Lys Lys Leu Arg Arg Gln Met Arg Ala Phe
1250 1255 1260
Pro Ala Ala Pro Cys Cys Val Asp Val Ser Asp Arg Leu Arg Ala
1265 1270 1275
Leu Ala Pro Ser Ala Glu Cys Pro Ile Ala Glu Glu Asn Leu Ala
1280 1285 1290
Arg Gly Leu Leu Asp Leu Gly His Ala Gly Arg Leu Gly Ile Ser
1295 1300 1305
Cys Thr Arg Leu Arg Arg Leu Arg Asn Lys Thr Ala His Gln Met
1310 1315 1320
Lys Val Gln His Phe Tyr Gln Gln Leu Leu Ser Asp Val Ala Trp
1325 1330 1335
Ala Ser Leu Asp Leu Pro Ser Leu Val Ala Glu His Leu Pro Gly
1340 1345 1350
Arg Gln Glu His Val Phe Trp Lys Leu Val Leu Val Leu Pro Asp
1355 1360 1365
Val Glu Glu Gln Ser Pro Glu Ser Cys Gly Arg Ile Leu Ala Asn
1370 1375 1380
Trp Leu Lys Val Lys Phe Met Gly Asp Glu Gly Ser Val Asp Asp
1385 1390 1395
Thr Ser Ser Asp Ala Gly Gly Ile Gln Thr Leu Ser Leu Phe Asn
1400 1405 1410
Ser Leu Ser Ser Lys Gly Asp Gln Met Ile Ser Val Asn Val Cys
1415 1420 1425
Ile Lys Val Ala His Gly Ala Leu Ser Asp Gly Ala Ile Asp Ala
1430 1435 1440
Val Glu Thr Gln Lys Asp Leu Leu Gly Ala Ser Gly Leu Met Leu
1445 1450 1455
Leu Leu Pro Pro Lys Met Lys Ser Glu Asp Met Ala Glu Glu Asp
1460 1465 1470
Val Tyr Trp Leu Ser Ala Leu Leu Gln Leu Lys Gln Leu Leu Gln
1475 1480 1485
Ala Lys Pro Phe Gln Pro Ala Leu Pro Leu Val Val Leu Val Pro
1490 1495 1500
Ser Pro Gly Gly Asp Ala Val Glu Lys Glu Val Glu Asp Gly Leu
1505 1510 1515
Met Leu Gln Asp Leu Val Ser Ala Lys Leu Ile Ser Asp Tyr Thr
1520 1525 1530
Val Thr Glu Ile Pro Asp Thr Ile Asn Asp Leu Gln Gly Ser Thr
1535 1540 1545
Lys Val Leu Gln Ala Val Gln Trp Leu Val Ser His Cys Pro His
1550 1555 1560
Ser Leu Asp Leu Cys Cys Gln Thr Leu Ile Gln Tyr Val Glu Asp
1565 1570 1575
Gly Ile Gly His Glu Phe Ser Gly Arg Phe Phe His Asp Arg Arg
1580 1585 1590
Glu Arg Arg Leu Gly Gly Leu Ala Ser Gln Glu Pro Gly Ala Ile
1595 1600 1605
Ile Glu Leu Phe Asn Ser Val Leu Gln Phe Leu Ala Ser Val Val
1610 1615 1620
Ser Ser Glu Gln Leu Cys Asp Leu Ser Trp Pro Val Thr Glu Phe
1625 1630 1635
Ala Glu Ala Gly Gly Ser Arg Leu Leu Pro His Leu His Trp Asn
1640 1645 1650
Ala Pro Glu His Leu Ala Trp Leu Lys Gln Ala Val Leu Gly Phe
1655 1660 1665
Gln Leu Pro Gln Met Asp Leu Pro Pro Leu Gly Ala Pro Trp Leu
1670 1675 1680
Pro Val Cys Ser Met Val Val Gln Tyr Ala Ser Gln Ile Pro Ser
1685 1690 1695
Ser Arg Gln Thr Gln Pro Val Leu Gln Ser Gln Val Glu Asn Leu
1700 1705 1710
Leu His Arg Thr Tyr Cys Arg Trp Lys Ser Lys Ser Pro Ser Pro
1715 1720 1725
Val His Gly Ala Gly Pro Ser Val Met Glu Ile Pro Trp Asp Asp
1730 1735 1740
Leu Ile Ala Leu Cys Ile Asn His Lys Leu Arg Asp Trp Thr Pro
1745 1750 1755
Pro Arg Leu Pro Val Thr Ser Glu Ala Leu Ser Glu Asp Gly Gln
1760 1765 1770
Ile Cys Val Tyr Phe Phe Lys Asn Asp Leu Lys Lys Tyr Asp Val
1775 1780 1785
Pro Leu Ser Trp Glu Gln Ala Arg Leu Gln Thr Gln Lys Glu Leu
1790 1795 1800
Gln Leu Arg Glu Gly Arg Leu Ala Ile Lys Pro Phe His Pro Ser
1805 1810 1815
Ala Asn Asn Phe Pro Ile Pro Leu Leu His Met His Arg Asn Trp
1820 1825 1830
Lys Arg Ser Thr Glu Cys Ala Gln Glu Gly Arg Ile Pro Ser Thr
1835 1840 1845
Glu Asp Leu Met Arg Gly Ala Ser Ala Glu Glu Leu Leu Ala Gln
1850 1855 1860
Cys Leu Ser Ser Ser Leu Leu Leu Glu Lys Glu Glu Asn Lys Arg
1865 1870 1875
Phe Glu Asp Gln Leu Gln Gln Trp Leu Ser Glu Asp Ser Gly Ala
1880 1885 1890
Phe Thr Asp Leu Thr Ser Leu Pro Leu Tyr Leu Pro Gln Thr Leu
1895 1900 1905
Val Ser Leu Ser His Thr Ile Glu Pro Val Met Lys Thr Ser Val
1910 1915 1920
Thr Thr Ser Pro Gln Ser Asp Met Met Arg Glu Gln Leu Gln Leu
1925 1930 1935
Ser Glu Ala Thr Gly Thr Cys Leu Gly Glu Arg Leu Lys His Leu
1940 1945 1950
Glu Arg Leu Ile Arg Ser Ser Arg Glu Glu Glu Val Ala Ser Glu
1955 1960 1965
Leu His Leu Ser Ala Leu Leu Asp Met Val Asp Ile
1970 1975 1980
<210>112
<211>1669
<212>PRT
<213>人
<400>112
Met Gly Pro Arg Leu Ser Val Trp Leu Leu Leu Leu Pro Ala Ala Leu
1 5 10 15
Leu Leu His Glu Glu His Ser Arg Ala Ala Ala Lys Gly Gly Cys Ala
20 25 30
Gly Ser Gly Cys Gly Lys Cys Asp Cys His Gly Val Lys Gly Gln Lys
35 40 45
Gly Glu Arg Gly Leu Pro Gly Leu Gln Gly Val Ile Gly Phe Pro Gly
50 55 60
Met Gln Gly Pro Glu Gly Pro Gln Gly Pro Pro Gly Gln Lys Gly Asp
65 70 75 80
Thr Gly Glu Pro Gly Leu Pro Gly Thr Lys Gly Thr Arg Gly Pro Pro
85 90 95
Gly Ala Ser Gly Tyr Pro Gly Asn Pro Gly Leu Pro Gly Ile Pro Gly
100 105 110
Gln Asp Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly Cys Asn Gly Thr
115 120 125
Lys Gly Glu Arg Gly Pro Leu Gly Pro Pro Gly Leu Pro Gly Phe Ala
130 135 140
Gly Asn Pro Gly Pro Pro Gly Leu Pro Gly Met Lys Gly Asp Pro Gly
145 150 155 160
Glu Ile Leu Gly His Val Pro Gly Met Leu Leu Lys Gly Glu Arg Gly
165 170 175
Phe Pro Gly Ile Pro Gly Thr Pro Gly Pro Pro Gly Leu Pro Gly Leu
180 185 190
Gln Gly Pro Val Gly Pro Pro Gly Phe Thr Gly Pro Pro Gly Pro Pro
195 200 205
Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Gln Met Gly Leu Ser Phe
210 215 220
Gln Gly Pro Lys Gly Asp Lys Gly Asp Gln Gly Val Ser Gly Pro Pro
225 230 235 240
Gly Val Pro Gly Gln Ala Gln Val Gln Glu Lys Gly Asp Phe Ala Thr
245 250 255
Lys Gly Glu Lys Gly Gln Lys Gly Glu Pro Gly Phe Gln Gly Met Pro
260 265 270
Gly Val Gly Glu Lys Gly Glu Pro Gly Lys Pro Gly Pro Arg Gly Lys
275 280 285
Pro Gly Lys Asp Gly Asp Lys Gly Glu Lys Gly Ser Pro Gly Phe Pro
290 295 300
Gly Glu Pro Gly Tyr Pro Gly Leu Ile Gly Arg Gln Gly Pro Gln Gly
305 310 315 320
Glu Lys Gly Glu Ala Gly Pro Pro Gly Pro Pro Gly Ile Val Ile Gly
325 330 335
Thr Gly Pro Leu Gly Glu Lys Gly Glu Arg Gly Tyr Pro Gly Thr Pro
340 345 350
Gly Pro Arg Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Leu Pro Gly
355 360 365
Gln Pro Gly Pro Pro Gly Leu Pro Val Pro Gly Gln Ala Gly Ala Pro
370 375 380
Gly Phe Pro Gly Glu Arg Gly Glu Lys Gly Asp Arg Gly Phe Pro Gly
385 390 395 400
Thr Ser Leu Pro Gly Pro Ser Gly Arg Asp Gly Leu Pro Gly Pro Pro
405 410 415
Gly Ser Pro Gly Pro Pro Gly Gln Pro Gly Tyr Thr Asn Gly Ile Val
420 425 430
Glu Cys Gln Pro Gly Pro Pro Gly Asp Gln Gly Pro Pro Gly Ile Pro
435 440 445
Gly Gln Pro Gly Phe Ile Gly Glu Ile Gly Glu Lys Gly Gln Lys Gly
450 455 460
Glu Ser Cys Leu Ile Cys Asp Ile Asp Gly Tyr Arg Gly Pro Pro Gly
465 470 475 480
Pro Gln Gly Pro Pro Gly Glu Ile Gly Phe Pro Gly Gln Pro Gly Ala
485 490 495
Lys Gly Asp Arg Gly Leu Pro Gly Arg Asp Gly Val Ala Gly Val Pro
500 505 510
Gly Pro Gln Gly Thr Pro Gly Leu Ile Gly Gln Pro Gly Ala Lys Gly
515 520 525
Glu Pro Gly Glu Phe Tyr Phe Asp Leu Arg Leu Lys Gly Asp Lys Gly
530 535 540
Asp Pro Gly Phe Pro Gly Gln Pro Gly Met Pro Gly Arg Ala Gly Ser
545 550 555 560
Pro Gly Arg Asp Gly His Pro Gly Leu Pro Gly Pro Lys Gly Ser Pro
565 570 575
Gly Ser Val Gly Leu Lys Gly Glu Arg Gly Pro Pro Gly Gly Val Gly
580 585 590
Phe Pro Gly Ser Arg Gly Asp Thr Gly Pro Pro Gly Pro Pro Gly Tyr
595 600 605
Gly Pro Ala Gly Pro Ile Gly Asp Lys Gly Gln Ala Gly Phe Pro Gly
610 615 620
Gly Pro Gly Ser Pro Gly Leu Pro Gly Pro Lys Gly Glu Pro Gly Lys
625 630 635 640
Ile Val Pro Leu Pro Gly Pro Pro Gly Ala Glu Gly Leu Pro Gly Ser
645 650 655
Pro Gly Phe Pro Gly Pro Gln Gly Asp Arg Gly Phe Pro Gly Thr Pro
660 665 670
Gly Arg Pro Gly Leu Pro Gly Glu Lys Gly Ala Val Gly Gln Pro Gly
675 680 685
Ile Gly Phe Pro Gly Pro Pro Gly Pro Lys Gly Val Asp Gly Leu Pro
690 695 700
Gly Asp Met Gly Pro Pro Gly Thr Pro Gly Arg Pro Gly Phe Asn Gly
705 710 715 720
Leu Pro Gly Asn Pro Gly Val Gln Gly Gln Lys Gly Glu Pro Gly Val
725 730 735
Gly Leu Pro Gly Leu Lys Gly Leu Pro Gly Leu Pro Gly Ile Pro Gly
740 745 750
Thr Pro Gly Glu Lys Gly Ser Ile Gly Val Pro Gly Val Pro Gly Glu
755 760 765
His Gly Ala Ile Gly Pro Pro Gly Leu Gln Gly Ile Arg Gly Glu Pro
770 775 780
Gly Pro Pro Gly Leu Pro Gly Ser Val Gly Ser Pro Gly Val Pro Gly
785 790 795 800
Ile Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Gly Gln Gly Pro Pro
805 810 815
Gly Leu Ser Gly Pro Pro Gly Ile Lys Gly Glu Lys Gly Phe Pro Gly
820 825 830
Phe Pro Gly Leu Asp Met Pro Gly Pro Lys Gly Asp Lys Gly Ala Gln
835 840 845
Gly Leu Pro Gly Ile Thr Gly Gln Ser Gly Leu Pro Gly Leu Pro Gly
850 855 860
Gln Gln Gly Ala Pro Gly Ile Pro Gly Phe Pro Gly Ser Lys Gly Glu
865 870 875 880
Met Gly Val Met Gly Thr Pro Gly Gln Pro Gly Ser Pro Gly Pro Val
885 890 895
Gly Ala Pro Gly Leu Pro Gly Glu Lys Gly Asp His Gly Phe Pro Gly
900 905 910
Ser Ser Gly Pro Arg Gly Asp Pro Gly Leu Lys Gly Asp Lys Gly Asp
915 920 925
Val Gly Leu Pro Gly Lys Pro Gly Ser Met Asp Lys Val Asp Met Gly
930 935 940
Ser Met Lys Gly Gln Lys Gly Asp Gln Gly Glu Lys Gly Gln Ile Gly
945 950 955 960
Pro Ile Gly Glu Lys Gly Ser Arg Gly Asp Pro Gly Thr Pro Gly Val
965 970 975
Pro Gly Lys Asp Gly Gln Ala Gly Gln Pro Gly Gln Pro Gly Pro Lys
980 985 990
Gly Asp Pro Gly Ile Ser Gly Thr Pro Gly Ala Pro Gly Leu Pro Gly
995 1000 1005
Pro Lys Gly Ser Val Gly Gly Met Gly Leu Pro Gly Thr Pro Gly
1010 1015 1020
Glu Lys Gly Val Pro Gly Ile Pro Gly Pro Gln Gly Ser Pro Gly
1025 1030 1035
Leu Pro Gly Asp Lys Gly Ala Lys Gly Glu Lys Gly Gln Ala Gly
1040 1045 1050
Pro Pro Gly Ile Gly Ile Pro Gly Leu Arg Gly Glu Lys Gly Asp
1055 1060 1065
Gln Gly Ile Ala Gly Phe Pro Gly Ser Pro Gly Glu Lys Gly Glu
1070 1075 1080
Lys Gly Ser Ile Gly Ile Pro Gly Met Pro Gly Ser Pro Gly Leu
1085 1090 1095
Lys Gly Ser Pro Gly Ser Val Gly Tyr Pro Gly Ser Pro Gly Leu
1100 1105 1110
Pro Gly Glu Lys Gly Asp Lys Gly Leu Pro Gly Leu Asp Gly Ile
1115 1120 1125
Pro Gly Val Lys Gly Glu Ala Gly Leu Pro Gly Thr Pro Gly Pro
1130 1135 1140
Thr Gly Pro Ala Gly Gln Lys Gly Glu Pro Gly Ser Asp Gly Ile
1145 1150 1155
Pro Gly Ser Ala Gly Glu Lys Gly Glu Pro Gly Leu Pro Gly Arg
1160 1165 1170
Gly Phe Pro Gly Phe Pro Gly Ala Lys Gly Asp Lys Gly Ser Lys
1175 1180 1185
Gly Glu Val Gly Phe Pro Gly Leu Ala Gly Ser Pro Gly Ile Pro
1190 1195 1200
Gly Ser Lys Gly Glu Gln Gly Phe Met Gly Pro Pro Gly Pro Gln
1205 1210 1215
Gly Gln Pro Gly Leu Pro Gly Ser Pro Gly His Ala Thr Glu Gly
1220 1225 1230
Pro Lys Gly Asp Arg Gly Pro Gln Gly Gln Pro Gly Leu Pro Gly
1235 1240 1245
Leu Pro Gly Pro Met Gly Pro Pro Gly Leu Pro Gly Ile Asp Gly
1250 1255 1260
Val Lys Gly Asp Lys Gly Asn Pro Gly Trp Pro Gly Ala Pro Gly
1265 1270 1275
Val Pro Gly Pro Lys Gly Asp Pro Gly Phe Gln Gly Met Pro Gly
1280 1285 1290
Ile Gly Gly Ser Pro Gly Ile Thr Gly Ser Lys Gly Asp Met Gly
1295 1300 1305
Pro Pro Gly Val Pro Gly Phe Gln Gly Pro Lys Gly Leu Pro Gly
1310 1315 1320
Leu Gln Gly Ile Lys Gly Asp Gln Gly Asp Gln Gly Val Pro Gly
1325 1330 1335
Ala Lys Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Tyr Asp
1340 1345 1350
Ile Ile Lys Gly Glu Pro Gly Leu Pro Gly Pro Glu Gly Pro Pro
1355 1360 1365
Gly Leu Lys Gly Leu Gln Gly Leu Pro Gly Pro Lys Gly Gln Gln
1370 1375 1380
Gly Val Thr Gly Leu Val Gly Ile Pro Gly Pro Pro Gly Ile Pro
1385 1390 1395
Gly Phe Asp Gly Ala Pro Gly Gln Lys Gly Glu Met Gly Pro Ala
1400 1405 1410
Gly Pro Thr Gly Pro Arg Gly Phe Pro Gly Pro Pro Gly Pro Asp
1415 1420 1425
Gly Leu Pro Gly Ser Met Gly Pro Pro Gly Thr Pro Ser Val Asp
1430 1435 1440
His Gly Phe Leu Val Thr Arg His Ser Gln Thr Ile Asp Asp Pro
1445 1450 1455
Gln Cys Pro Ser Gly Thr Lys Ile Leu Tyr His Gly Tyr Ser Leu
1460 1465 1470
Leu Tyr Val Gln Gly Asn Glu Arg Ala His Gly Gln Asp Leu Gly
1475 1480 1485
Thr Ala Gly Ser Cys Leu Arg Lys Phe Ser Thr Met Pro Phe Leu
1490 1495 1500
Phe Cys Asn Ile Asn Asn Val Cys Asn Phe Ala Ser Arg Asn Asp
1505 1510 1515
Tyr Ser Tyr Trp Leu Ser Thr Pro Glu Pro Met Pro Met Ser Met
1520 1525 1530
Ala Pro Ile Thr Gly Glu Asn Ile Arg Pro Phe Ile Ser Arg Cys
1535 1540 1545
Ala Val Cys Glu Ala Pro Ala Met Val Met Ala Val His Ser Gln
1550 1555 1560
Thr Ile Gln Ile Pro Pro Cys Pro Ser Gly Trp Ser Ser Leu Trp
1565 1570 1575
Ile Gly Tyr Ser Phe Val Met His Thr Ser Ala Gly Ala Glu Gly
1580 1585 1590
Ser Gly Gln Ala Leu Ala Ser Pro Gly Ser Cys Leu Glu Glu Phe
1595 1600 1605
Arg Ser Ala Pro Phe Ile Glu Cys His Gly Arg Gly Thr Cys Asn
1610 1615 1620
Tyr Tyr Ala Asn Ala Tyr Ser Phe Trp Leu Ala Thr Ile Glu Arg
1625 1630 1635
Ser Glu Met Phe Lys Lys Pro Thr Pro Ser Thr Leu Lys Ala Gly
1640 1645 1650
Glu Leu Arg Thr His Val Ser Arg Cys Gln Val Cys Met Arg Arg
1655 1660 1665
Thr
<210>113
<211>465
<212>PRT
<213>人
<400>113
Met Val Ser Ser Gln Lys Leu Glu Lys Pro Ile Glu Met Gly Ser Ser
1 5 10 15
Glu Pro Leu Pro Ile Ala Asp Gly Asp Arg Arg Arg Lys Lys Lys Arg
20 25 30
Arg Gly Arg Ala Thr Asp Ser Leu Pro Gly Lys Phe Glu Asp Met Tyr
35 40 45
Lys Leu Thr Ser Glu Leu Leu Gly Glu Gly Ala Tyr Ala Lys Val Gln
50 55 60
Gly Ala Val Ser Leu Gln Asn Gly Lys Glu Tyr Ala Val Lys Ile Ile
65 70 75 80
Glu Lys Gln Ala Gly His Ser Arg Ser Arg Val Phe Arg Glu Val Glu
85 90 95
Thr Leu Tyr Gln Cys Gln Gly Asn Lys Asn Ile Leu Glu Leu Ile Glu
100 105 110
Phe Phe Glu Asp Asp Thr Arg Phe Tyr Leu Val Phe Glu Lys Leu Gln
115 120 125
Gly Gly Ser Ile Leu Ala His Ile Gln Lys Gln Lys His Phe Asn Glu
130 135 140
Arg Glu Ala Ser Arg Val ValArg Asp Val Ala Ala Ala Leu Asp Phe
145 150 155 160
Leu His Thr Lys Asp Lys Val Ser Leu Cys His Leu Gly Trp Ser Ala
165 170 175
Met Ala Pro Ser Gly Leu Thr Ala Ala Pro Thr Ser Leu Gly Ser Ser
180 185 190
Asp Pro Pro Thr Ser Ala Ser Gln Val Ala Gly Thr Thr Gly Ile Ala
195 200 205
His Arg Asp Leu Lys Pro Glu Asn Ile Leu Cys Glu Ser Pro Glu Lys
210 215 220
Val Ser Pro Val Lys Ile Cys Asp Phe Asp Leu Gly Ser Gly Met Lys
225 230 235 240
Leu Asn Asn Ser Cys Thr Pro Ile Thr Thr Pro Glu Leu Thr Thr Pro
245 250 255
Cys Gly Ser Ala Glu Tyr Met Ala Pro Glu Val Val Glu Val Phe Thr
260 265 270
Asp Gln Ala Thr Phe Tyr Asp Lys Arg Cys Asp Leu Trp Ser Leu Gly
275 280 285
Val Val Leu Tyr Ile Met Leu Ser Gly Tyr Pro Pro Phe Val Gly His
290 295 300
Cys Gly Ala Asp Cys Gly Trp Asp Arg Gly Glu Val Cys Arg Val Cys
305 310 315 320
Gln Asn Lys Leu Phe Glu Ser Ile Gln Glu Gly Lys Tyr Glu Phe Pro
325 330 335
Asp Lys Asp Trp Ala His Ile Ser Ser Glu Ala Lys Asp Leu Ile Ser
340 345 350
Lys Leu Leu Val Arg Asp Ala Lys Gln Arg Leu Ser Ala Ala Gln Val
355 360 365
Leu Gln His Pro Trp Val Gln Gly Gln Ala Pro Glu Lys Gly Leu Pro
370 375 380
Thr Pro Gln Val Leu Gln Arg Asn Ser Ser Thr Met Asp Leu Thr Leu
385 390 395 400
Phe Ala Ala Glu Ala Ile Ala Leu Asn Arg Gln Leu Ser Gln His Glu
405 410 415
Glu Asn Glu Leu Ala Glu Glu Pro Glu Ala Leu Ala Asp Gly Leu Cys
420 425 430
Ser Met Lys Leu Ser Pro Pro Cys Lys Ser Arg Leu Ala Arg Arg Arg
435 440 445
Ala Leu Ala Gln Ala Gly Arg Gly Glu Asp Arg Ser Pro Pro Thr Ala
450 455 460
Leu
465
<210>114
<211>193
<212>PRT
<213>人
<400>114
Met Ala Arg Ala Arg Gln Glu Gly Ser Ser Pro Glu Pro Val Glu Gly
1 5 10 15
Leu Ala Arg Asp Gly Pro Arg Pro Phe Pro Leu Gly Arg Leu Val Pro
20 25 30
Ser Ala Val Ser Cys Gly Leu Cys Glu Pro Gly Leu Ala Ala Ala Pro
35 40 45
Ala Ala Pro Thr Leu Leu Pro Ala Ala Tyr Leu Cys Ala Pro Thr Ala
50 55 60
Pro Pro Ala Val Thr Ala Ala Leu Gly Gly Ser Arg Trp Pro Gly Gly
65 70 75 80
Pro Arg Ser Arg Pro Arg Gly Pro Arg Pro Asp Gly Pro Gln Pro Ser
85 90 95
Leu Ser Leu Ala Glu Gln His Leu Glu Ser Pro Val Pro Ser Ala Pro
100 105 110
Gly Ala Leu Ala Gly Gly Pro Thr Gln Ala Ala Pro Gly Val Arg Gly
115 120 125
Glu Glu Glu Gln Trp Ala Arg Glu Ile Gly Ala Gln Leu Arg Arg Met
130 135 140
Ala Asp Asp Leu Asn Ala Gln Tyr Glu Arg Arg Arg Gln Glu Glu Gln
145 150 155 160
Gln Arg His Arg Pro Ser Pro Trp Arg Val Leu Tyr Asn Leu Ile Met
165 170 175
Gly Leu Leu Pro Leu Pro Arg Gly His Arg Ala Pro Glu Met Glu Pro
180 185 190
Asn
<210>115
<211>897
<212>PRT
<213>人
<400>115
Met Glu Tyr Thr Lys Gln Leu Ile Leu Ser Cys Leu Leu Asn Ile Cys
1 5 10 15
Gln Lys Leu Ser Pro Asp Gly Gly Lys Ile Pro Lys Asp Ile Leu Asp
20 25 30
Glu Glu Lys Phe Asn Val Glu Leu Ile Val Gln Cys Ile Arg Leu Ser
35 40 45
Glu Met Pro Gln Thr His His His Ala Leu Leu Leu Leu Gly Thr Val
50 55 60
Ala Gly Ile Phe Pro Asp Lys Val Leu His Asn Ile Met Ser Ile Phe
65 70 75 80
Thr Phe Met Gly Ala Asn Val Met Arg Leu Asp Asp Thr Tyr Ser Phe
85 90 95
Gln Val Ile Asn Lys Thr Val Lys Met Val Ile Pro Ala Leu Ile Gln
100 105 110
Ser Asp Ser Gly Asp Ser Ile Glu Val Ser Arg Asn Val Glu Glu Ile
115 120 125
Val Val Lys Ile Ile Ser Val Phe Val Asp Ala Leu Pro His Val Pro
130 135 140
Glu His Arg Arg Leu Pro Ile Leu Val Gln Leu Val Asp Thr Leu Gly
145 150 155 160
Ala Glu Lys Phe Leu Trp Ile Leu Leu Ile Leu Leu Phe Glu Gln Tyr
165 170 175
Val Thr Lys Thr Val Leu Ala Ala Ala Tyr Gly Glu Lys Asp Ala Ile
180 185 190
Leu Glu Ala Asp Thr Glu Phe Trp Phe Ser Val Cys Cys Glu Phe Ser
195 200 205
Val Gln His Gln Ile Gln Ser Leu Met Asn Ile Leu Gln Tyr Leu Leu
210 215 220
Lys Leu Pro Glu Glu Lys Glu Glu Thr Ile Pro Lys Ala Val Ser Phe
225 230 235 240
Asn Lys Ser Glu Ser Gln Glu Glu Met Leu Gln Val Phe Asn Val Glu
245 250 255
Thr His Thr Ser Lys Gln Leu Arg His Phe Lys Phe Leu Ser Val Ser
260 265 270
Phe Met Ser Gln Leu Leu Ser Ser Asn Asp Phe Leu Lys Lys Val Val
275 280 285
Glu Ser Gly Gly Pro Glu Ile Leu Lys Gly Leu Glu Glu Arg Leu Leu
290 295 300
Glu Thr Val Leu Gly Tyr Ile Ser Ala Val Ala Gln Ser Met Glu Arg
305 310 315 320
Asn Ala Asp Lys Leu Thr Val Lys Phe Trp Arg Ala Leu Leu Ser Lys
325 330 335
Ala Tyr Asp Leu Leu Asp Lys Val Asn Ala Leu Leu Pro Thr Glu Thr
340 345 350
Phe Ile Pro Val Ile Arg Gly Leu Val Gly Asn Pro Leu Pro Ser Val
355 360 365
Arg Arg Lys Ala Leu Asp Leu Leu Asn Asn Lys Leu Gln Gln Asn Ile
370 375 380
Ser Trp Lys Lys Thr Ile Val Thr Arg Phe Leu Lys Leu Val Pro Asp
385 390 395 400
Leu Leu Ala Ile Val Gln Arg Lys Lys Lys Glu Gly Glu Glu Glu Gln
405 410 415
Ala Ile Asn Arg Gln Thr Ala Leu Tyr Thr Leu Lys Leu Leu Cys Lys
420 425 430
Asn Phe Gly Ala Glu Asn Pro Asp Pro Phe Val Pro Val Leu Ser Thr
435 440 445
Ala Val Lys Leu Ile Ala Pro Glu Arg Lys Glu Glu Lys Asn Val Leu
450 455 460
Gly Ser Ala Leu Leu Cys Ile Ala Glu Val Thr Ser Thr Leu Glu Ala
465 470 475 480
Leu Ala Ile Pro Gln Leu Pro Ser Leu Met Pro Ser Leu Leu Thr Thr
485 490 495
Met Lys Asn Thr Ser Glu Leu Val Ser Ser Glu Val Tyr Leu Leu Ser
500 505 510
Ala Leu Ala Ala Leu Gln Lys Val Val Glu Thr Leu Pro His Phe Ile
515 520 525
Ser Pro Tyr Leu Glu Gly Ile Leu Ser Gln Val Ile His Leu Glu Lys
530 535 540
Ile Thr Ser Glu Met Gly Ser Ala Ser Arg Ala Asn Ile Arg Leu Thr
545 550 555 560
Ser Leu Lys Lys Thr Leu Ala Thr Thr Leu Ala Pro Arg Val Leu Leu
565 570 575
Pro Ala Ile Lys Lys Thr Tyr Lys Gln Ile Glu Lys Asn Trp Lys Asn
580 585 590
His Met Gly Pro Phe Met Ser Ile Leu Gln Glu His Ile Gly Ala Met
595 600 605
Lys Lys Glu Glu Leu Thr Ser His Gln Ser Gln Leu Thr Ala Phe Phe
610 615 620
Leu Glu Ala Leu Asp Phe Arg Ala Gln His Ser Glu Asn Asp Leu Glu
625 630 635 640
Glu Val Gly Lys Thr Glu Asn Cys Ile Ile Asp Cys Leu Val Ala Met
645 650 655
Val Val Lys Leu Ser Glu Val Thr Phe Arg Pro Leu Phe Phe Lys Leu
660 665 670
Phe Asp Trp Ala Lys Thr Glu Asp Ala Pro Lys Asp Arg Leu Leu Thr
675 680 685
Phe Tyr Asn Leu Ala Asp Cys Ile Ala Glu Lys Leu Lys Gly Leu Phe
690 695 700
Thr Leu Phe Ala Gly His Leu Val Lys Pro Phe Ala Asp Thr Leu Asp
705 710 715 720
Gln Val Asn Ile Ser Lys Thr Asp Glu Ala Phe Phe Asp Ser Glu Asn
725 730 735
Asp Pro Glu Lys Cys Cys Leu Leu Leu Gln Phe Ile Leu Asn Cys Leu
740 745 750
Tyr Lys Ile Phe Leu Phe Asp Thr Gln His Phe Ile Ser Lys Glu Arg
755 760 765
Ala Gly Ala Leu Met Met Pro Leu Val Asp Gln Leu Val Asn Arg Leu
770 775 780
Gly Gly Glu Glu Lys Phe Gln Glu Arg Val Thr Lys His Leu Ile Pro
785 790 795 800
Cys Ile Ala Gln Phe Ser Val Ala Met Ala Asp Asp Ser Leu Trp Lys
805 810 815
Pro Leu Asn Tyr Gln Ile Leu Leu Lys Thr Arg Asp Ser Ser Pro Lys
820 825 830
Val Arg Phe Ala Ala Leu Ile Thr Val Leu Ala Leu Ala Glu Lys Leu
835 840 845
Lys Glu Asn TyrIle Val Leu Leu Pro Glu Ser Ile Pro Phe Leu Ala
850 855 860
Glu Leu Met Glu Asp Glu Cys Glu Glu Val Glu His Gln Cys Gln Lys
865 870 875 880
Thr Ile Gln Gln Leu Glu Thr Val Leu Gly Glu Pro Leu Gln Ser Tyr
885 890 895
Phe
<210>116
<211>201
<212>PRT
<213>人
<400>116
Met Asp Leu Ser Leu Leu Trp Val Leu Leu Pro Leu Val Thr Met Ala
1 5 10 15
Trp Gly Gln Tyr Gly Asp Tyr Gly Tyr Pro Tyr Gln Gln Tyr His Asp
20 25 30
Tyr Ser Asp Asp Gly Trp Val Asn Leu Asn Arg Gln Gly Phe Ser Tyr
35 40 45
Gln Cys Pro Gln Gly Gln Val Ile Val Ala Val Arg Ser Ile Phe Ser
50 55 60
Lys Lys Glu Gly Ser Asp Arg Gln Trp Asn Tyr Ala Cys Met Pro Thr
65 70 75 80
Pro Gln Ser Leu Gly Glu Pro Thr Glu Cys Trp Trp Glu Glu Ile Asn
85 90 95
Arg Ala Gly Met Glu Trp Tyr Gln Thr Cys Ser Asn Asn Gly Leu Val
100 105 110
Ala Gly Phe Gln Ser Arg Tyr Phe Glu Ser Val Leu Asp Arg Glu Trp
115 120 125
Gln Phe Tyr Cys Cys Arg Tyr Ser Lys Arg Cys Pro Tyr Ser Cys Trp
130 135 140
Leu Thr Thr Glu Tyr Pro Gly His Tyr Gly Glu Glu Met Asp Met Ile
145 150 155 160
Ser Tyr Asn Tyr Asp Tyr Tyr Ile Arg Gly Ala Thr Thr Thr Phe Ser
165 170 175
Ala Val Glu Arg Asp Arg Gln Trp Lys Phe Ile Met Cys Arg Met Thr
180 185 190
Glu Tyr Asp Cys Glu Phe Ala Asn Val
195 200
<210>117
<211>265
<212>PRT
<213>人
<400>117
Met Pro Met Arg His Arg Lys Lys Ala Ala Asp Lys Asn Leu Pro Cys
1 5 10 15
Arg Pro Leu Val Cys Ala Val Leu Asp Leu Met Val Glu Phe Ile Val
20 25 30
Thr His Met Met Lys Glu Phe Pro Met Asp Leu Tyr Ile Arg Cys Ile
35 40 45
Gln Val Val His Lys Leu Leu Cys Tyr Gln Lys Lys Cys Arg Val Arg
50 55 60
Leu His Tyr Thr Trp Arg Glu Leu Trp Ser Ala Leu Ile Asn Leu Leu
65 70 75 80
Lys Phe Leu Met Ser Asn Glu Thr Val Leu Leu Ala Lys Hi s Asn Ile
85 90 95
Phe Thr Leu Ala Leu Met Ile Val Asn Leu Phe Asn Met Phe Ile Thr
100 105 110
Tyr Gly Asp Thr Phe Leu Pro Thr Pro Ser Ser Tyr Asp Glu Leu Tyr
115 120 125
Tyr Glu Ile Ile Arg Met His Gln Ser Phe Asp Asn Leu Tyr Ser Met
130 135 140
Val Leu Arg Leu Ser Thr Asn Ala Gly Gln Trp Lys Glu Ala Ala Ser
145 150 155 160
Lys Val Thr His Ala Leu Val Asn Ile Arg Ala Ile Ile Asn His Phe
165 170 175
Asn Pro Lys Ile Glu Ser Tyr Ala Ala Val Asn His Ile Ser Gln Leu
180 185 190
Ser Glu Glu Gln Val Leu Glu Val Val Arg Ala Asn Tyr Asp Thr Leu
195 200 205
Thr Leu Lys Leu Gln Asp Gly Leu Asp Gln Tyr Glu Arg Tyr Ser Glu
210 215 220
Gln His Lys Glu Ala Ala Phe Phe Lys Glu Leu Val Arg Ser Ile Ser
225 230 235 240
Thr Asn Val Arg Arg Asn Leu Val Phe His Thr Leu Ser Gln Glu Val
245 250 255
Leu Leu Lys Glu Phe Ser Thr Ile Ser
260 265
<210>118
<211>278
<212>PRT
<213>人
<400>118
Met Lys Leu Phe Gln Arg Ser Thr Pro Ala Ile Thr Leu Glu Ser Pro
1 5 10 15
Asp Ile Lys Tyr Pro Leu Arg Leu Ile Asp Arg Glu Ile Ile Ser His
20 25 30
Asp Thr Arg Arg Phe Arg Phe Ala Leu Pro Ser Pro Gln His Ile Leu
35 40 45
Gly Leu Pro Val Gly Gln His Ile Tyr Leu Ser Ala Arg Ile Asp Gly
50 55 60
Asn Leu Val Val Arg Pro Tyr Thr Pro Ile Ser Ser Asp Asp Asp Lys
65 70 75 80
Gly Phe Val Asp Leu Val Ile Lys Val Tyr Phe Lys Asp Thr His Pro
85 90 95
Lys Phe Pro Ala Gly Gly Lys Met Ser Gln Tyr Leu Glu Ser Met Gln
100 105 110
Ile Gly Asp Thr Ile Glu Phe Arg Gly Pro Ser Gly Leu Leu Val Tyr
115 120 125
Gln Gly Lys Gly Lys Phe Ala Ile Arg Pro Asp Lys Lys Ser Asn Pro
130 135 140
Ile Ile Arg Thr Val Lys Ser Val Gly Met Ile Ala Gly Gly Thr Gly
145 150 155 160
Ile Thr Pro Met Leu Gln Val Ile Arg Ala Ile Met Lys Asp Pro Asp
165 170 175
Asp His Thr Val Cys His Leu Leu Phe Ala Asn Gln Thr Glu Lys Asp
180 185 190
Ile Leu Leu Arg Pro Glu Leu Glu Glu Leu Arg Asn Lys His Ser Ala
195 200 205
Arg Phe Lys Leu Trp Tyr Thr Leu Asp Arg Ala Pro Glu Ala Trp Asp
210 215 220
Tyr Gly Gln Gly Phe Val Asn Glu Glu Met Ile Arg Asp His Leu Pro
225 230 235 240
Pro Pro Glu Glu Glu Pro Leu Val Leu Met Cys Gly Pro Pro Pro Met
245 250 255
Ile Gln Tyr Ala Cys Leu Pro Asn Leu Asp His Val Gly His Pro Thr
260 265 270
Glu Arg Cys Phe Val Phe
275
<210>119
<211>322
<212>PRT
<213>人
<400>119
Met Glu Gly Ile Ser Asn Phe Lys Thr Pro Ser Lys Leu Ser Glu Lys
1 5 10 15
Lys Lys Ser Val Leu Cys Ser Thr Pro Thr Ile Asn Ile Pro Ala Ser
20 25 30
Pro Phe Met Gln Lys Leu Gly Phe Gly Thr Gly Val Asn Val Tyr Leu
35 40 45
Met Lys Arg Ser Pro Arg Gly Leu Ser His Ser Pro Trp Ala Val Lys
50 55 60
Lys Ile Asn Pro Ile Cys Asn Asp His Tyr Arg Ser Val Tyr Gln Lys
65 70 75 80
Arg Leu Met Asp Glu Ala Lys Ile Leu Lys Ser Leu His His Pro Asn
85 90 95
Ile Val Gly Tyr Arg Ala Phe Thr Glu Ala Asn Asp Gly Ser Leu Cys
100 105 110
Leu Ala Met Glu Tyr Gly Gly Glu Lys Ser Leu Asn Asp Leu Ile Glu
115 120 125
Glu Arg Tyr Lys Ala Ser Gln Asp Pro Phe Pro Ala Ala Ile Ile Leu
130 135 140
Lys Val Ala Leu Asn Met Ala Arg Gly Leu Lys Tyr Leu His Gln Glu
145 150 155 160
Lys Lys Leu Leu His Gly Asp Ile Lys Ser Ser Asn Val Val Ile Lys
165 170 175
Gly Asp Phe Glu Thr Ile Lys Ile Cys Asp Val Gly Val Ser Leu Pro
180 185 190
Leu Asp Glu Asn Met Thr Val Thr Asp Pro Glu Ala Cys Tyr Ile Gly
195 200 205
Thr Glu Pro Trp Lys Pro Lys Glu Ala Val Glu Glu Asn Gly Val Ile
210 215 220
Thr Asp Lys Ala Asp Ile Phe Ala Phe Gly Leu Thr Leu Trp Glu Met
225 230 235 240
Met Thr Leu Ser Ile Pro His Ile Asn Leu Ser Asn Asp Asp Asp Asp
245 250 255
Glu Asp Lys Thr Phe Asp Glu Ser Asp Phe Asp Asp Glu Ala Tyr Tyr
260 265 270
Ala Ala Leu Gly Thr Arg Pro Pro Ile Asn Met Glu Glu Leu Asp Glu
275 280 285
Ser Tyr Gln Lys Val Ile Glu Leu Phe Ser Val Cys Thr Asn Glu Asp
290 295 300
Pro Lys Asp Arg Pro Ser Ala Ala His Ile ValGlu Ala Leu Glu Thr
305 310 315 320
Asp Val
<210>120
<211>878
<212>PRT
<213>人
<400>120
Met Ala Thr Ala Pro Ser Tyr Pro Ala Gly Leu Pro Gly Ser Pro Gly
1 5 10 15
Pro Gly Ser Pro Pro Pro Pro Gly Gly Leu Glu Leu Gln Ser Pro Pro
20 25 30
Pro Leu Leu Pro Gln Ile Pro Ala Pro Gly Ser Gly Val Ser Phe His
35 40 45
Ile Gln Ile Gly Leu Thr Arg Glu Phe Val Leu Leu Pro Ala Ala Ser
50 55 60
Glu Leu Ala His Val Lys Gln Leu Ala Cys Ser Ile Val Asp Gln Lys
65 70 75 80
Phe Pro Glu Cys Gly Phe Tyr Gly Leu Tyr Asp Lys Ile Leu Leu Phe
85 90 95
Lys His Asp Pro Thr Ser Ala Asn Leu Leu Gln Leu Val Arg Ser Ser
100 105 110
Gly Asp Ile Gln Glu Gly Asp Leu Val Glu Val Val Leu Ser Ala Ser
115 120 125
Ala Thr Phe Glu Asp Phe Gln Ile Arg Pro His Ala Leu Thr Val His
130 135 140
Ser Tyr Arg Ala Pro Ala Phe Cys Asp His Cys Gly Glu Met Leu Phe
145 150 155 160
Gly Leu Val Arg Gln Gly Leu Lys Cys Asp Gly Cys Gly Leu Asn Tyr
165 170 175
His Lys Arg Cys Ala Phe Ser Ile Pro Asn Asn Cys Ser Gly Ala Arg
180 185 190
Lys Arg Arg Leu Ser Ser Thr Ser Leu Ala Ser Gly His Ser Val Arg
195 200 205
Leu Gly Thr Ser Glu Ser Leu Pro Cys Thr Ala Glu Glu Leu Ser Arg
210 215 220
Ser Thr Thr Glu Leu Leu Pro Arg Arg Pro Pro Ser Ser Ser Ser Ser
225 230 235 240
Ser Ser Ala Ser Ser Tyr Thr Gly Arg Pro Ile Glu Leu Asp Lys Met
245 250 255
Leu Leu Ser Lys Val Lys Val Pro His Thr Phe Leu Ile His Ser Tyr
260 265 270
Thr Arg Pro Thr Val Cys Gln Ala Cys Lys Lys Leu Leu Lys Gly Leu
275 280 285
Phe Arg Gln Gly Leu Gln Cys Lys Asp Cys Lys Phe Asn Cys His Lys
290 295 300
Arg Cys Ala Thr Arg Val Pro Asn Asp Cys Leu Gly Glu Ala Leu Ile
305 310 315 320
Asn Gly Asp Val Pro Met Glu Glu Ala Thr Asp Phe Ser Glu Ala Asp
325 330 335
Lys Ser Ala Leu Met Asp Glu Ser Glu Asp Ser Gly Val Ile Pro Gly
340 345 350
Ser His Ser Glu Asn Ala Leu His Ala Ser Glu Glu Glu Glu Gly Glu
355 360 365
Gly Gly Lys Ala Gln Ser Ser Leu Gly Tyr Ile Pro Leu Met Arg Val
370 375 380
Val Gln Ser Val Arg His Thr Thr Arg Lys Ser Ser Thr Thr Leu Arg
385 390 395 400
Glu Gly Trp Val Val His Tyr Ser Asn Lys Asp Thr Leu Arg Lys Arg
405 410 415
His Tyr Trp Arg Leu Asp Cys Lys Cys Ile Thr Leu Phe Gln Asn Asn
420 425 430
Thr Thr Asn Arg Tyr Tyr Lys Glu Ile Pro Leu Ser Glu Ile Leu Thr
435 440 445
Val Glu Ser Ala Gln Asn Phe Ser Leu Val Pro Pro Gly Thr Asn Pro
450 455 460
His Cys Phe Glu Ile ValThr Ala Asn Ala Thr Tyr Phe Val Gly Glu
465 470 475 480
Met Pro Gly Gly Thr Pro Gly Gly Pro Ser Gly Gln Gly Ala Glu Ala
485 490 495
Ala Arg Gly Trp Glu Thr Ala Ile Arg Gln Ala Leu Met Pro Val Ile
500 505 510
Leu Gln Asp Ala Pro Ser Ala Pro Gly His Ala Pro His Arg Gln Ala
515 520 525
Ser Leu Ser Ile Ser Val Ser Asn Ser Gln Ile Gln Glu Asn Val Asp
530 535 540
Ile Ala Thr Val Tyr Gln Ile Phe Pro Asp Glu Val Leu Gly Ser Gly
545 550 555 560
Gln Phe Gly Val Val Tyr Gly Gly Lys His Arg Lys Thr Gly Arg Asp
565 570 575
Val Ala Val Lys Val Ile Asp Lys Leu Arg Phe Pro Thr Lys Gln Glu
580 585 590
Ser Gln Leu Arg Asn Glu Val Ala Ile Leu Gln Ser Leu Arg His Pro
595 600 605
Gly Ile Val Asn Leu Glu Cys Met Phe Glu Thr Pro Glu Lys Val Phe
610 615 620
Val Val Met Glu Lys Leu His Gly Asp Met Leu Glu Met Ile Leu Ser
625 630 635 640
Ser Glu Lys Gly Arg Leu Pro Glu Arg Leu Thr Lys Phe Leu Ile Thr
645 650 655
Gln Ile Leu Val Ala Leu Arg His Leu His Phe Lys Asn Ile Val His
660 665 670
Cys Asp Leu Lys Pro Glu Asn Val Leu Leu Ala Ser Ala Asp Pro Phe
675 680 685
Pro Gln Val Lys Leu Cys Asp Phe Gly Phe Ala Arg Ile Ile Gly Glu
690 695 700
Lys Ser Phe Arg Arg Ser Val Val Gly Thr Pro Ala Tyr Leu Ala Pro
705 710 715 720
Glu Val Leu Leu Asn Gln Gly Tyr Asn Arg Ser Leu Asp Met Trp Ser
725 730 735
Val Gly Val Ile Met Tyr Val Ser Leu Ser Gly Thr Phe Pro Phe Asn
740 745 750
Glu Asp Glu Asp Ile Asn Asp Gln Ile Gln Asn Ala Ala Phe Met Tyr
755 760 765
Pro Ala Ser Pro Trp Ser His Ile Ser Ala Gly Ala Ile Asp Leu Ile
770 775 780
Asn Asn Leu Leu Gln Val Lys Met Arg Lys Arg Tyr Ser Val Asp Lys
785 790 795 800
Ser Leu Ser His Pro Trp Leu Gln Glu Tyr Gln Thr Trp Leu Asp Leu
805 810 815
Arg Glu Leu Glu Gly Lys Met Gly Glu Arg Tyr Ile Thr His Glu Ser
820 825 830
Asp Asp Ala Arg Trp Glu Gln Phe Ala Ala Glu His Pro Leu Pro Gly
835 840 845
Ser Gly Leu Pro Thr Asp Arg Asp Leu Gly Gly Ala Cys Pro Pro Gln
850 855 860
Asp His Asp Met Gln Gly Leu Ala Glu Arg Ile Ser Val Leu
865 870 875
<210>121
<211>400
<212>PRT
<213>人
<400>121
Met Thr Ser Tyr Ser Tyr Arg Gln Ser Ser Ala Thr Ser Ser Phe Gly
1 5 10 15
Gly Leu Gly Gly Gly Ser Val Arg Phe Gly Pro Gly Val Ala Phe Arg
20 25 30
Ala Pro Ser Ile His Gly Gly Ser Gly Gly Arg Gly Val Ser Val Ser
35 40 45
Ser Ala Arg Phe Val Ser Ser Ser Ser Ser Gly Ala Tyr Gly Gly Gly
50 55 60
Tyr Gly Gly Val Leu Thr Ala Ser Asp Gly Leu Leu Ala Gly Asn Glu
65 70 75 80
Lys Leu Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser Tyr Leu Asp
85 90 95
Lys Val Arg Ala Leu Glu Ala Ala Asn Gly Glu Leu Glu Val Lys Ile
100 105 110
Arg Asp Trp Tyr Gln Lys Gln Gly Pro Gly Pro Ser Arg Asp Tyr Ser
115 120 125
His Tyr Tyr Thr Thr Ile Gln Asp Leu Arg Asp Lys Ile Leu Gly Ala
130 135 140
Thr Ile Glu Asn Ser Arg Ile Val Leu Gln Ile Asp Asn Ala Arg Leu
145 150 155 160
Ala Ala Asp Asp Phe Arg Thr Lys Phe Glu Thr Glu Gln Ala Leu Arg
165 170 175
Met Ser Val Glu Ala Asp Ile Asn Gly Leu Arg Arg Val Leu Asp Glu
180 185 190
Leu Thr Leu Ala Arg Thr Asp Leu Glu Met Gln Ile Glu Gly Leu Lys
195 200 205
Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu Glu Glu Ile Ser Thr
210 215 220
Leu Arg Gly Gln Val Gly Gly Gln Val Ser Val Glu Val Asp Ser Ala
225 230 235 240
Pro Gly Thr Asp Leu Ala Lys Ile Leu Ser Asp Met Arg Ser Gln Tyr
245 250 255
Glu Val Met Ala Glu Gln Asn Arg Lys Asp Ala Glu Ala Trp Phe Thr
260 265 270
Ser Arg Thr Glu Glu Leu Asn Arg Glu Val Ala Gly His Thr Glu Gln
275 280 285
Leu Gln Met Ser Arg Ser Glu Val Thr Asp Leu Arg Arg Thr Leu Gln
290 295 300
Gly Leu Glu Ile Glu Leu Gln Ser Gln Leu Ser Met Lys Ala Ala Leu
305 310 315 320
Glu Asp Thr Leu Ala Glu Thr Glu Ala Arg Phe Gly Ala Gln Leu Ala
325 330 335
His Ile Gln Ala Leu Ile Ser Gly Ile Glu Ala Gln Leu Gly Asp Val
340 345 350
Arg Ala Asp Ser Glu Arg Gln Asn Gln Glu Tyr Gln Arg Leu Met Asp
355 360 365
Ile Lys Ser Arg Leu Glu Gln Glu Ile Ala Thr Tyr Arg Ser Leu Leu
370 375 380
Glu Gly Gln Glu Asp His Tyr Asn Asn Leu Ser Ala Ser Lys Val Leu
385 390 395 400
<210>122
<211>520
<212>PRT
<213>人
<400>122
Met Arg Ser Pro Glu Gly Tyr Leu Arg Gly Asn Met Ser Glu Asn Glu
1 5 10 15
Glu Glu Glu Ile Ser Gln Gln Glu Gly Ser Gly Asp Tyr Glu Val Glu
20 25 30
Glu Ile Pro Phe Gly Leu Glu Pro Gln Ser Pro Gly Phe Glu Pro Gln
35 40 45
Ser Pro Glu Phe Glu Pro Gln Ser Pro Arg Phe Glu Pro Glu Ser Pro
50 55 60
Gly Phe Glu Ser Arg Ser Pro Gly Leu Val Pro Pro Ser Pro Glu Phe
65 70 75 80
Ala Pro Arg Ser Pro Glu Ser Asp Ser Gln Ser Pro Glu Phe Glu Ser
85 90 95
Gln Ser Pro Arg Tyr Glu Pro Gln Ser Pro Gly Tyr Glu Pro Arg Ser
100 105 110
Pro Gly Tyr Glu Pro Arg Ser Pro Gly Tyr Glu Ser Glu Ser Ser Arg
115 120 125
Tyr Glu Ser Gln Asn Thr Glu Leu Lys Thr Gln Ser Pro Glu Phe Glu
130 135 140
Ala Gln Ser Ser Lys Phe Gln Glu Gly Ala Glu Met Leu Leu Asn Pro
145 150 155 160
Asp Glu Lys Ser Pro Leu Asn Ile Ser Val Gly Val His Pro Leu Asp
165 170 175
Ser Phe Thr Gln Gly Phe Gly Glu Gln Pro Thr Gly Asp Leu Pro Ile
180 185 190
Gly Pro Pro Phe Glu Met Pro Thr Gly Ala Leu Leu Ser Thr Pro Gln
195 200 205
Phe Glu Met Leu Gln Asn Pro Leu Gly Leu Thr Gly Ala Leu Arg Gly
210 215 220
Pro Gly Arg Arg Gly Gly Arg Ala Arg Gly Gly Gln Gly Pro Arg Pro
225 230 235 240
Asn Ile Cys Gly Ile Cys Gly Lys Ser Phe Gly Arg Gly Ser Thr Leu
245 250 255
Ile Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
260 265 270
Val Cys Ser Lys Ala Phe Ser Gln Ser Ser Asp Leu Ile Lys His Gln
275 280 285
Arg Thr His Thr Gly Glu Arg Pro Tyr Lys Cys Pro Arg Cys Gly Lys
290 295 300
Ala Phe Ala Asp Ser Ser Tyr Leu Leu Arg His Gln Arg Thr His Ser
305 310 315 320
Gly Gln Lys Pro Tyr Lys Cys Pro His Cys Gly Lys Ala Phe Gly Asp
325 330 335
Ser Ser Tyr Leu Leu Arg His Gln Arg Thr His Ser His Glu Arg Pro
340 345 350
Tyr Ser Cys Thr Glu Cys Gly Lys Cys Tyr Ser Gln Asn Ser Ser Leu
355 360 365
Arg Ser His Gln Arg Val His Thr Gly Gln Arg Pro Phe Ser Cys Gly
370 375 380
Ile Cys Gly Lys Ser Phe Ser Gln Arg Ser Ala Leu Ile Pro His Ala
385 390 395 400
Arg Ser His Ala Arg Glu Lys Pro Phe Lys Cys Pro Glu Cys Gly Lys
405 410 415
Arg Phe Gly Gln Ser Ser Val Leu Ala Ile His Ala Arg Thr His Leu
420 425 430
Pro Gly Arg Thr Tyr Ser Cys Pro Asp Cys Gly Lys Thr Phe Asn Arg
435 440 445
Ser Ser Thr Leu Ile Gln His Gln Arg Ser His Thr Gly Glu Arg Pro
450 455 460
Tyr Arg Cys Ala Val Cys Gly Lys Gly Phe Cys Arg Ser Ser Thr Leu
465 470 475 480
Leu Gln His His Arg Val His Ser Gly Glu Arg Pro Tyr Lys Cys Asp
485 490 495
Asp Cys Gly Lys Ala Phe Ser Gln Ser Ser Asp Leu Ile Arg His Gln
500 505 510
Arg Thr His Ala Ala Gly Arg Arg
515 520
<210>123
<211>383
<212>PRT
<213>人
<400>123
Met Glu Arg Arg Ala Arg Ser Ser Ser Arg Glu Ser Arg Gly Arg Gly
1 5 10 15
Gly Arg Thr Pro His Lys Glu Asn Lys Arg Ala Lys Ala Glu Arg Ser
20 25 30
Gly Gly Gly Arg Gly Arg Gln Glu Ala Gly Pro Glu Pro Ser Gly Ser
35 40 45
Gly Arg Ala Gly Thr Pro Gly Glu Pro Arg Ala Pro Ala Ala Thr Val
50 55 60
Val Asp Val Asp Glu Val Arg Gly Ser Gly Glu Glu Gly Thr Glu Val
65 70 75 80
Val Ala Leu Leu Glu Ser Glu Arg Pro Glu Glu Gly Thr Lys Ser Ser
85 90 95
Gly Leu Gly Ala Cys Glu Trp Leu Leu Val Leu Ile Ser Leu Leu Phe
100 105 110
Ile Ile Met Thr Phe Pro Phe Ser Ile Trp Phe Cys Val Lys Val Val
115 120 125
Gln Glu Tyr Glu Arg Val Ile Ile Phe Arg Leu Gly His Leu Leu Pro
130 135 140
Gly Arg Ala Lys Gly Pro Gly Leu Phe Phe Phe Leu Pro Cys Leu Asp
145 150 155 160
Thr Tyr His Lys Val Asp Leu Arg Leu Gln Thr Leu Glu Ile Pro Phe
165 170 175
His Glu Ile Val Thr Lys Asp Met Phe Ile Met Glu Ile Asp Ala Ile
180 185 190
Cys Tyr Tyr Arg Met Glu Asn Ala Ser Leu Leu Leu Ser Ser Leu Ala
195 200 205
His Val Ser Lys Ala Val Gln Phe Leu Val Gln Thr Thr Met Lys Arg
210 215 220
Leu Leu Ala His Arg Ser Leu Thr Glu Ile Leu Leu Glu Arg Lys Ser
225 230 235 240
Ile Ala Gln Asp Ala Lys Val Ala Leu Asp Ser Val Thr Cys Ile Trp
245 250 255
Gly Ile Lys Val Glu Arg Ile Glu Ile Lys Asp Val Arg Leu Pro Ala
260 265 270
Gly Leu Gln His Ser Leu Ala Val Glu Ala Glu Ala Gln Arg Gln Ala
275 280 285
Lys Val Arg Met Ile Ala Ala Glu Ala Glu Lys Ala Ala Ser Glu Ser
290 295 300
Leu Arg Met Ala Ala Glu Ile Leu Ser Gly Thr Pro Ala Ala Val Gln
305 310 315 320
Leu Arg Tyr Leu His Thr Leu Gln Ser Leu Ser Thr Glu Lys Pro Ser
325 330 335
Thr Val Val Leu Pro Leu Pro Phe Asp Leu Leu Asn Cys Leu Ser Ser
340 345 350
Pro Ser Asn Arg Thr Gln Gly Ser Leu Pro Phe Pro Ser Pro Ser Lys
355 360 365
Pro Val Glu Pro Leu Asn Pro Lys Lys Lys Asp Ser Pro Met Leu
370 375 380
<210>124
<211>128
<212>PRT
<213>人
<400>124
Met Thr Ser Leu Phe Ala Gln Glu Ile Arg Leu Ser Lys Arg His Glu
l 5 10 15
Glu Ile Val Ser Gln Arg Leu Met Leu Leu Gln Gln Met Glu Asn Lys
20 25 30
Leu Gly Asp Gln His Thr Glu Lys Ala Ser Gln Leu Gln Thr Val Glu
35 40 45
Thr Ala Phe Lys Arg Asn Leu Ser Leu Leu Lys Asp Ile Glu Ala Ala
50 55 60
Glu Lys Ser Leu Gln Thr Arg Ile His Pro Leu Pro Arg Pro Glu Val
65 70 75 80
Val Ser Leu Glu Thr Arg Tyr Trp Ala Ser Val Glu Glu Tyr Ile Pro
85 90 95
Lys Trp Glu Gln Phe Leu Leu Gly Arg Ala Pro Tyr Pro Phe Ala Val
100 105 110
Glu Asn Gln Asn Glu Ala Glu Asn Thr Ile Gln Asn Glu Ala Gln Arg
115 120 125
<210>125
<211>363
<212>PRT
<213>人
<400>125
Met Lys Gly Asn Ser Thr Leu Ala Thr Thr Ser Lys Asn Ile Thr Ser
1 5 10 15
Gly Leu His Phe Gly Leu Val Asn Ile Ser Gly Asn Asn Glu Ser Thr
20 25 30
Leu Asn Cys Ser Gln Lys Pro Ser Asp Lys His Leu Asp Ala Ile Pro
35 40 45
Ile Leu Tyr Tyr Ile Ile Phe Val Ile Gly Phe Leu Val Asn Ile Val
50 55 60
Val Val Thr Leu Phe Cys Cys Gln Lys Gly Pro Lys Lys Val Ser Ser
65 70 75 80
Ile Tyr Ile Phe Asn Leu Ala Val Ala Asp Leu Leu Leu Leu Ala Thr
85 90 95
Leu Pro Leu Trp Ala Thr Tyr Tyr Ser Tyr Arg Tyr Asp Trp Leu Phe
100 105 110
Gly Pro Val Met Cys Lys Val Phe Gly Ser Phe Leu Thr Leu Asn Met
115 120 125
Phe Ala Ser Ile Phe Phe Ile Thr Cys Met Ser Val Asp Arg Tyr Gln
130 135 140
Ser Val Ile Tyr Pro Phe Leu Ser Gln Arg Arg Asn Pro Trp Gln Ala
145 150 155 160
Ser Tyr Ile Val Pro Leu Val Trp Cys Met Ala Cys Leu Ser Ser Leu
165 170 175
Pro Thr Phe Tyr Phe Arg Asp Val Arg Thr Ile Glu Tyr Leu Gly Val
180 185 190
Asn Ala Cys Ile Met Ala Phe Pro Pro Glu Lys Tyr Ala Gln Trp Ser
195 200 205
Ala Gly Ile Ala Leu Met Lys Asn Ile Leu Gly Phe Ile Ile Pro Leu
210 215 220
Ile Phe Ile Ala Thr Cys Tyr Phe Gly Ile Arg Lys His Leu Leu Lys
225 230 235 240
Thr Asn Ser Tyr Gly Lys Asn Arg Ile Thr Arg Asp Gln Val Leu Lys
245 250 255
Met Ala Ala Ala Val Val Leu Ala Phe Ile Ile Cys Trp Leu Pro Phe
260 265 270
His Val Leu Thr Phe Leu Asp Ala Leu Ala Trp Met Gly Val Ile Asn
275 280 285
Ser Cys Glu Val Ile Ala Val Ile Asp Leu Ala Leu Pro Phe Ala Ile
290 295 300
Leu Leu Gly Phe Thr Asn Ser Cys Val Asn Pro Phe Leu Tyr Cys Phe
305 310 315 320
Val Gly Asn Arg Phe Gln Gln Lys Leu Arg Ser Val Phe Arg Val Pro
325 330 335
Ile Thr Trp Leu Gln Gly Lys Arg Glu Ser Met Ser Cys Arg Lys Ser
340 345 350
Ser Ser Leu Arg Glu Met Glu Thr Phe Val Ser
355 360
<210>126
<211>366
<212>PRT
<213>人
<400>126
Met Asp Phe Leu Asn Ser Ser Asp Gln Asn Leu Thr Ser Glu Glu Leu
1 5 10 15
Leu Asn Arg Met Pro Ser Lys Ile Leu Val Ser Leu Thr Leu Ser Gly
20 25 30
Leu Ala Leu Met Thr Thr Thr Ile Asn Ser Leu Val Ile Ala Ala Ile
35 40 45
Ile Val Thr Arg Lys Leu His His Pro Ala Asn Tyr Leu Ile Cys Ser
50 55 60
Leu Ala Val Thr Asp Phe Leu Val Ala Val Leu Val Met Pro Phe Ser
65 70 75 80
Ile Val Tyr Ile Val Arg Glu Ser Trp Ile Met Gly Gln Val Val Cys
85 90 95
Asp Ile Trp Leu Ser Val Asp Ile Thr Cys Cys Thr Cys Ser Ile Leu
100 105 110
His Leu Ser Ala Ile Ala Leu Asp Arg Tyr Arg Ala Ile Thr Asp Ala
115 120 125
Val Glu Tyr Ala Arg Lys Arg Thr Pro Lys His Ala Gly Ile Met Ile
130 135 140
Thr Ile Val Trp Ile Ile Ser Val Phe Ile Ser Met Pro Pro Leu Phe
145 150 155 160
Trp Arg His Gln Gly Thr Ser Arg Asp Asp Glu Cys Ile Ile Lys His
165 170 175
Asp His Ile Val Ser Thr Ile Tyr Ser Thr Phe Gly Ala Phe Tyr Ile
180 185 190
Pro Leu Ala Leu Ile Leu Ile Leu Tyr Tyr Lys Ile Tyr Arg Ala Ala
195 200 205
Lys Thr Leu Tyr His Lys Arg Gln Ala Ser Arg Ile Ala Lys Glu Glu
210 215 220
Val Asn Gly Gln Val Leu Leu Glu Ser Gly Glu Lys Ser Thr Lys Ser
225 230 235 240
Val Ser Thr Ser Tyr Val Leu Glu Lys Ser Leu Ser Asp Pro Ser Thr
245 250 255
Asp Phe Asp Lys Ile His Ser Thr Val Arg Ser Leu Arg Ser Glu Phe
260 265 270
Lys His Glu Lys Ser Trp Arg Arg Gln Lys Ile Ser Gly Thr Arg Glu
275 280 285
Arg Lys Ala Ala Thr Thr Leu Gly Leu Ile Leu Gly Ala Phe Val Ile
290 295 300
Cys Trp Leu Pro Phe Phe Val Lys Glu Leu Val Val Asn Val Cys Asp
305 310 315 320
Lys Cys Lys Ile Ser Glu Glu Met Ser Asn Phe Leu Ala Trp Leu Gly
325 330 335
Tyr Leu Asn Ser Leu Ile Asn Pro Leu Ile Tyr Thr Ile Phe Asn Glu
340 345 350
Asp Phe Lys Lys Ala Phe Gln Lys Leu Val Arg Cys Arg Cys
355 360 365
<210>127
<211>747
<212>PRT
<213>人
<400>127
Met Ser Lys Leu Lys Ser Ser Glu Ser Val Arg Val Val Val Arg Cys
1 5 10 15
Arg Pro Met Asn Gly Lys Glu Lys Ala Ala Ser Tyr Asp Lys Val Val
20 25 30
Asp Val Asp Val Lys Leu Gly Gln Val Ser Val Lys Asn Pro Lys Gly
35 40 45
Thr Ala His Glu Met Pro Lys Thr Phe Thr Phe Asp Ala Val Tyr Asp
50 55 60
Trp Asn Ala Lys Gln Phe Glu Leu Tyr Asp Glu Thr Phe Arg Pro Leu
65 70 75 80
Val Asp Ser Val Leu Gln Gly Phe Asn Gly ThrIle Phe Ala Tyr Gly
85 90 95
Gln Thr Gly Thr Gly Lys Thr Tyr Thr Met Glu Gly Ile Arg Gly Asp
100 105 110
Pro Glu Lys Arg Gly Val Ile Pro Asn Ser Phe Asp His Ile Phe Thr
115 120 125
His Ile Ser Arg Ser Gln Asn Gln Gln Tyr Leu Val Arg Ala Ser Tyr
130 135 140
Leu Glu Ile Tyr Gln Glu Glu Ile Arg Asp Leu Leu Ser Lys Asp Gln
145 150 155 160
Thr Lys Arg Leu Glu Leu Lys Glu Arg Pro Asp Thr Gly Val Tyr Val
165 170 175
Lys Asp Leu Ser Ser Phe Val Thr Lys Ser Val Lys Glu Ile Glu His
180 185 190
Val Met Asn Val Gly Asn Gln Asn Arg Ser Val Gly Ala Thr Asn Met
195 200 205
Asn Glu His Ser Ser Arg Ser His Ala Ile Phe Val Ile Thr Ile Glu
210 215 220
Cys Ser Glu Val Gly Leu Asp Gly Glu Asn His Ile Arg Val Gly Lys
225 230 235 240
Leu Asn Leu Val Asp Leu Ala Gly Ser Glu Arg Gln Ala Lys Thr Gly
245 250 255
Ala Gln Gly Glu Arg Leu Lys Glu Ala Thr Lys Ile Asn Leu Ser Leu
260 265 270
Ser Ala Leu Gly Asn Val Ile Ser Ala Leu Val Asp Gly Lys Ser Thr
275 280 285
His Ile Pro Tyr Arg Asp Ser Lys Leu Thr Arg Leu Leu Gln Asp Ser
290 295 300
Leu Gly Gly Asn Ala Lys Thr Val Met Val Ala Asn Val Gly Pro Ala
305 310 315 320
Ser Tyr Asn Val Glu Glu Thr Leu Thr Thr Leu Arg Tyr Ala Asn Arg
325 330 335
Ala Lys Asn Ile Lys Asn Lys Pro Arg Val Asn Glu Asp Pro Lys Asp
340 345 350
Ala Leu Leu Arg Glu Phe Gln Glu Glu Ile Ala Arg Leu Lys Ala Gln
355 360 365
Leu Glu Lys Arg Ser Ile Gly Arg Arg Lys Arg Arg Glu Lys Arg Arg
370 375 380
Glu Gly Gly Gly Ser Gly Gly Gly Gly Glu Glu Glu Glu Glu Glu Gly
385 390 395 400
Glu Glu Gly Glu Glu Glu Gly Asp Asp Lys Asp Asp Tyr Trp Arg Glu
405 410 415
Gln Gln Glu Lys Leu Glu Ile Glu Lys Arg Ala Ile Val Glu Asp His
420 425 430
Ser Leu Val Ala Glu Glu Lys Met Arg Leu Leu Lys Glu Lys Glu Lys
435 440 445
Lys Met Glu Asp Leu Arg Arg Glu Lys Asp Ala Ala Glu Met Leu Gly
450 455 460
Ala Lys Ile Lys Ala Met Glu Ser Lys Leu Leu Val Gly Gly Lys Asn
465 470 475 480
Ile Val Asp His Thr Asn Glu Gln Gln Lys Ile Leu Glu Gln Lys Arg
485 490 495
Gln Glu Ile Ala Glu Gln Lys Arg Arg Glu Arg Glu Ile Gln Gln Gln
500 505 510
Met Glu Ser Arg Asp Glu Glu Thr Leu Glu Leu Lys Glu Thr Tyr Ser
515 520 525
Ser Leu Gln Gln Glu Val Asp Ile Lys Thr Lys Lys Leu Lys Lys Leu
530 535 540
Phe Ser Lys Leu Gln Ala Val Lys Ala Glu Ile His Asp Leu Gln Glu
545 550 555 560
Glu His Ile Lys Glu Arg Gln Glu Leu Glu Gln Thr Gln Asn Glu Leu
565 570 575
Thr Arg Glu Leu Lys Leu Lys Hi s Leu Ile Ile Glu Asn Phe Ile Pro
580 585 590
Leu Glu Glu Lys Ser Lys Ile Met Asn Arg Ala Phe Phe Asp Glu Glu
595 600 605
Glu Asp His Trp Lys Leu His Pro Ile Thr Arg Leu Glu Asn Gln Gln
610 615 620
Met Met Lys Arg Pro Val Ser Ala Val Gly Tyr Lys Arg Pro Leu Ser
625 630 635 640
Gln His Ala Arg Met Ser Met Met Ile Arg Pro Glu Ala Arg Tyr Arg
645 650 655
Ala Glu Asn Ile Val Leu Leu Glu Leu Asp Met Pro Ser Arg Thr Thr
660 665 670
Arg Asp Tyr Glu Gly Pro Ala Ile Ala Pro Lys Val Gln Ala Ala Leu
675 680 685
Asp Ala Ala Leu Gln Asp Glu Asp Glu Ile Gln Val Asp Ala Ser Ser
690 695 700
Phe Glu Ser Thr Ala Asn Lys Lys Ser Lys Ala Arg Pro Lys Ser Gly
705 710 715 720
Arg Lys Ser Gly Ser Ser Ser Ser Ser Ser Gly Thr Pro Ala Ser Gln
725 730 735
Leu Tyr Pro Gln Ser Arg Gly Leu Val Pro Lys
740 745
<210>128
<211>172
<212>PRT
<213>人
<400>128
Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala
1 5 10 15
Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu
20 25 30
Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro
35 40 45
Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val
50 55 60
Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu Pro
65 70 75 80
Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile
85 90 95
Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Val Val Tyr Leu
100 105 110
His Asn Asn Asn Ile Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro
115 120 125
Gly His Asn Thr Lys Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser
130 135 140
Asn Pro Val Gln Tyr Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys Val
145 150 155 160
Tyr Val Arg Ser Ala Ile Gln Leu Gly Asn Tyr Lys
165 170
<210>129
<211>268
<212>PRT
<213>人
<400>129
Met Glu Asp Phe Leu Leu Ser Asn Gly Tyr Gln Leu Gly Lys Thr Ile
1 5 10 15
Gly Glu Gly Thr Tyr Ser Lys Val Lys Glu Ala Phe Ser Lys Lys His
20 25 30
Gln Arg Lys Val Ala Ile Lys Val Ile Asp Lys Met Gly Gly Pro Glu
35 40 45
Glu Phe Ile Gln Arg Phe Leu Pro Arg Glu Leu Gln Ile Val Arg Thr
50 55 60
Leu Asp His Lys Asn Ile Ile Gln Val Tyr Glu Met Leu Glu Ser Ala
65 70 75 80
Asp Gly Lys Ile Cys Leu Val Met Glu Leu Ala Glu Gly Gly Asp Val
85 90 95
Phe Asp Cys Val Leu Asn Gly Gly Pro Leu Pro Glu Ser Arg Ala Lys
100 105 110
Ala Leu Phe Arg Gln Met Val Glu Ala Ile Arg Tyr Cys His Gly Cys
115 120 125
Gly Val Ala His Arg Asp Leu Lys Cys Glu Asn Ala Leu Leu Gln Gly
130 135 140
Phe Asn Leu Lys Leu Thr Asp Phe Gly Phe Ala Lys Val Leu Pro Lys
145 150 155 160
Ser His Arg Glu Leu Ser Gln Thr Phe Cys Gly Ser Thr Ala Tyr Ala
165 170 175
Ala Pro Glu Val Leu Gln Gly Ile Pro His Asp Ser Lys Lys Gly Asp
180 185 190
Val Trp Ser Met Gly Val Val Leu Tyr Val Met Leu Cys Ala Ser Leu
195 200 205
Pro Phe Asp Asp Thr Asp Ile Pro Lys Met Leu Trp Gln Gln Gln Lys
210 215 220
Gly Val Ser Phe Pro Thr His Leu Ser Ile Ser Ala Asp Cys Gln Asp
225 230 235 240
Leu Leu Lys Arg Leu Leu Glu Pro Asp MetIle Leu Arg Pro Ser Ile
245 250 255
Glu Glu Val Ser Trp His Pro Trp Leu Ala Ser Thr
260 265
<210>130
<211>133
<212>PRT
<213>人
<400>130
Met Arg Arg Ser Leu Arg Ala Gly Lys Arg Arg Gln Thr Ala Gly Arg
1 5 10 15
Lys Ser Lys Ser Pro Pro Lys Val Pro Ile Val Ile Gln Asp Asp Ser
20 25 30
Leu Pro Ala Gly Pro Pro Pro Gln Ile Arg Ile Leu Lys Arg Pro Thr
35 40 45
Ser Asn Gly Val Val Ser Ser Pro Asn Ser Thr Ser Arg Pro Thr Leu
50 55 60
Pro Val Lys Ser Leu Ala Gln Arg Glu Ala Glu Tyr Ala Glu Ala Arg
65 70 75 80
Lys Arg Ile Leu Gly Ser Ala Ser Pro Glu Glu Glu Gln Glu Lys Pro
85 90 95
Ile Leu Asp Arg Pro Thr Arg Ile Ser Gln Pro Glu Asp Ser Arg Gln
100 105 110
Pro Asn Asn Val Ile Arg Gln Pro Leu Gly Pro Asp Gly Ser Gln Gly
115 120 125
Phe Lys Gln Arg Arg
130
<210>131
<211>472
<212>PRT
<213>人
<400>131
Met Lys Ser Ile Leu Asp Gly Leu Ala Asp Thr Thr Phe Arg Thr Ile
1 5 10 15
Thr Thr Asp Leu Leu Tyr Val Gly Ser Asn Asp Ile Gln Tyr Glu Asp
20 25 30
Ile Lys Gly Asp Met Ala Ser Lys Leu Gly Tyr Phe Pro Gln Lys Phe
35 40 45
Pro Leu Thr Ser Phe Arg Gly Ser Pro Phe Gln Glu Lys Met Thr Ala
50 55 60
Gly Asp Asn Pro Gln Leu Val Pro Ala Asp Gln Val Asn Ile Thr Glu
65 70 75 80
Phe Tyr Asn Lys Ser Leu Ser Ser Phe Lys Glu Asn Glu Glu Asn Ile
85 90 95
Gln Cys Gly Glu Asn Phe Met Asp Ile Glu Cys Phe Met Val Leu Asn
100 105 110
Pro Ser Gln Gln Leu Ala Ile Ala Val Leu Ser Leu Thr Leu Gly Thr
115 120 125
Phe Thr Val Leu Glu Asn Leu Leu Val Leu Cys Val Ile Leu His Ser
130 135 140
Arg Ser Leu Arg Cys Arg Pro Ser Tyr His Phe Ile Gly Ser Leu Ala
145 150 155 160
Val Ala Asp Leu Leu Gly Ser Val Ile Phe Val Tyr Ser Phe Ile Asp
165 170 175
Phe His Val Phe His Arg Lys Asp Ser Arg Asn Val Phe Leu Phe Lys
180 185 190
Leu Gly Gly Val Thr Ala Ser Phe Thr Ala Ser Val Gly Ser Leu Phe
195 200 205
Leu Thr Ala Ile Asp Arg Tyr Ile Ser Ile His Arg Pro Leu Ala Tyr
210 215 220
Lys Arg Ile Val Thr Arg Pro Lys Ala Val Val Ala Phe Cys Leu Met
225 230 235 240
Trp Thr Ile Ala Ile Val Ile Ala Val Leu Pro Leu Leu Gly Trp Asn
245 250 255
Cys Glu Lys Leu Gln Ser Val Cys Ser Asp Ile Phe Pro His Ile Asp
260 265 270
Glu Thr Tyr Leu Met Phe Trp Ile Gly Val Thr Ser Val Leu Leu Leu
275 280 285
Phe Ile Val Tyr Ala Tyr Met Tyr Ile Leu Trp Lys Ala His Ser His
290 295 300
Ala Val Arg Met Ile Gln Arg Gly Thr Gln Lys Ser Ile Ile Ile His
305 310 315 320
Thr Ser Glu Asp Gly Lys Val Gln Val Thr Arg Pro Asp Gln Ala Arg
325 330 335
Met Asp Ile Arg Leu Ala Lys Thr Leu Val Leu Ile Leu Val Val Leu
340 345 350
Ile Ile Cys Trp Gly Pro Leu Leu Ala Ile Met Val Tyr Asp Val Phe
355 360 365
Gly Lys Met Asn Lys Leu Ile Lys Thr Val Phe Ala Phe Cys Ser Met
370 375 380
Leu Cys Leu Leu Asn Ser Thr Val Asn Pro Ile Ile Tyr Ala Leu Arg
385 390 395 400
Ser Lys Asp Leu Arg His Ala Phe Arg Ser Met Phe Pro Ser Cys Glu
405 410 415
Gly Thr Ala Gln Pro Leu Asp Asn Ser Met Gly Asp Ser Asp Cys Leu
420 425 430
His Lys His Ala Asn Asn Ala Ala Ser Val His Arg Ala Ala Glu Ser
435 440 445
Cys Ile Lys Ser Thr Val Lys Ile Ala Lys Val Thr Met Ser Val Ser
450 455 460
Thr Asp Thr Ser Ala Glu Ala Leu
465 470
<210>132
<211>361
<212>PRT
<213>人
<400>132
Met Ser Thr Ala Arg Glu Gln Pro Ile Phe Ser Thr Arg Ala His Val
1 5 10 15
Phe Gln Ile Asp Pro Ala Thr Lys Arg Asn Trp Ile Pro Ala Gly Lys
20 25 30
His Ala Leu Thr Val Ser Tyr Phe Tyr Asp Ala Thr Arg Asn Val Tyr
35 40 45
Arg Ile Ile Ser Ile Gly Gly Ala Lys Ala Ile Ile Asn Ser Thr Val
50 55 60
Thr Pro Asn Met Thr Phe Thr Lys Thr Ser Gln Lys Phe Gly Gln Trp
65 70 75 80
Ala Asp Ser Arg Ala Asn Thr ValTyr Gly Leu Gly Phe Ala Ser Glu
85 90 95
Gln His Leu Thr Gln Phe Ala Glu Lys Phe Gln Glu Val Lys Glu Ala
100 105 110
Ala Arg Leu Ala Arg Glu Lys Ser Gln Asp Gly Gly Glu Leu Thr Ser
115 120 125
Pro Ala Leu Gly Leu Ala Ser His Gln Val Pro Pro Ser Pro Leu Val
130 135 140
Ser Ala Asn Gly Pro Gly Glu Glu Lys Leu Phe Arg Ser Gln Ser Ala
145 150 155 160
Asp Ala Pro Gly Pro Thr Glu Arg Glu Arg Leu Lys Lys Met Leu Ser
165 170 175
Glu Gly Ser Val Gly Glu Val Gln Trp Glu Ala Glu Phe Phe Ala Leu
180 185 190
Gln Asp Ser Asn Asn Lys Leu Ala Gly Ala Leu Arg Glu Ala Asn Ala
195 200 205
Ala Ala Ala Gln Trp Arg Gln Gln Leu Glu Ala Gln Arg Ala Glu Ala
210 215 220
Glu Arg Leu Arg Gln Arg Val Ala Glu Leu Glu Ala Gln Ala Ala Ser
225 230 235 240
Glu Val Thr Pro Thr Gly Glu Lys Glu Gly Leu Gly Gln Gly Gln Ser
245 250 255
Leu Glu Gln Leu Glu Ala Leu Val Gln Thr Lys Asp Gln Glu Ile Gln
260 265 270
Thr Leu Lys Ser Gln Thr Gly Gly Pro Arg Glu Ala Leu Glu Ala Ala
275 280 285
Glu Arg Glu Glu Thr Gln Gln Lys Val Gln Asp Leu Glu Thr Arg Asn
290 295 300
Ala Glu Leu Glu His Gln Leu Arg Ala Met Glu Arg Ser Leu Glu Glu
305 310 315 320
Ala Arg Ala Glu Arg Glu Arg Ala Arg Ala Glu Val Gly Arg Ala Ala
325 330 335
Gln Leu Leu Asp Val Arg Leu Phe Glu Leu Ser Glu Leu Arg Glu Gly
340 345 350
Leu Ala Arg Leu Ala Glu Ala Ala Pro
355 360
<210>133
<211>362
<212>PRT
<213>人
<400>133
Met Gly Thr Glu Ala Thr Glu Gln Val Ser Trp Gly His Tyr Ser Gly
1 5 10 15
Asp Glu Glu Asp Ala Tyr Ser Ala Glu Pro Leu Pro Glu Leu Cys Tyr
20 25 30
Lys Ala Asp Val Gln Ala Phe Ser Arg Ala Phe Gln Pro Ser Val Ser
35 40 45
Leu Thr Val Ala Ala Leu Gly Leu Ala Gly Asn Gly Leu Val Leu Ala
50 55 60
Thr His Leu Ala Ala Arg Arg Ala Ala Arg Ser Pro Thr Ser Ala His
65 70 75 80
Leu Leu Gln Leu Ala Leu Ala Asp Leu Leu Leu Ala Leu Thr Leu Pro
85 90 95
Phe Ala Ala Ala Gly Ala Leu Gln Gly Trp Ser Leu Gly Ser Ala Thr
100 105 110
Cys Arg Thr Ile Ser Gly Leu Tyr Ser Ala Ser Phe His Ala Gly Phe
115 120 125
Leu Phe Leu Ala Cys Ile Ser Ala Asp Arg Tyr Val Ala Ile Ala Arg
130 135 140
Ala Leu Pro Ala Gly Pro Arg Pro Ser Thr Pro Gly Arg Ala His Leu
145 150 155 160
Val Ser Val Ile Val Trp Leu Leu Ser Leu Leu Leu Ala Leu Pro Ala
165 170 175
Leu Leu Phe Ser Gln Asp Gly Gln Arg Glu Gly Gln Arg Arg Cys Arg
180 185 190
Leu Ile Phe Pro Glu Gly Leu Thr Gln Thr Val Lys Gly Ala Ser Ala
195 200 205
Val Ala Gln Val Ala Leu Gly Phe Ala Leu Pro Leu Gly Val Met Val
210 215 220
Ala Cys Tyr Ala Leu Leu Gly Arg Thr Leu Leu Ala Ala Arg Gly Pro
225 230 235 240
Glu Arg Arg Arg Ala Leu Arg Val Val Val Ala Leu Val Ala Ala Phe
245 250 255
Val Val Leu Gln Leu Pro Tyr Ser Leu Ala Leu Leu Leu Asp Thr Ala
260 265 270
Asp Leu Leu Ala Ala Arg Glu Arg Ser Cys Pro Ala Ser Lys Arg Lys
275 280 285
Asp Val Ala Leu Leu Val Thr Ser Gly Leu Ala Leu Ala Arg Cys Gly
290 295 300
Leu Asn Pro Val Leu Tyr Ala Phe Leu Gly Leu Arg Phe Arg Gln Asp
305 310 315 320
Leu Arg Arg Leu Leu Arg Gly Gly Ser Ser Pro Ser Gly Pro Gln Pro
325 330 335
Arg Arg Gly Cys Pro Arg Arg Pro Arg Leu Ser Ser Cys Ser Ala Pro
340 345 350
Thr Glu Thr His Ser Leu Ser Trp Asp Asn
355 360
<210>134
<211>520
<212>PRT
<213>人
<400>134
Met Arg Val Glu Ser Gly Ser Ala Gln Glu Arg Gly Ile Leu Leu Glu
5 10 15
Ser Leu Ser Thr Leu Leu Glu Lys Thr Thr Ala Ser His Glu Gly Arg
20 25 30
Ala Pro Gly Asn Arg Glu Leu Thr Asp Leu Leu Pro Pro Glu Val Cys
35 40 45
Ser Leu Leu Asn Pro Ala Ala Ile Tyr Ala Asn Asn Glu Ile Ser Leu
50 55 60
Arg Asp Val Glu Val Tyr Gly Phe Asp Tyr Asp Tyr Thr Leu Ala Gln
65 70 75 80
Tyr Ala Asp Ala Leu His Pro Glu Ile Phe Ser Thr Ala Arg Asp Ile
85 90 95
Leu Ile Glu His Tyr Lys Tyr Pro Glu Gly Ile Arg Lys Tyr Asp Tyr
100 105 110
Asn Pro Ser Phe Ala Ile Arg Gly Leu His Tyr Asp Ile Gln Lys Ser
115 120 125
Leu Leu Met Lys Ile Asp Ala Phe His Tyr Val Gln Leu Gly Thr Ala
130 135 140
Tyr Arg Gly Leu Gln Pro Val Pro Asp Glu Glu Val Ile Glu Leu Tyr
145 150 155 160
Gly Gly Thr Gln His Ile Pro Leu Tyr Gln Met Ser Gly Phe Tyr Gly
165 170 175
Lys Gly Pro Ser Ile Lys Gln Phe Met Asp Ile Phe Ser Leu Pro Glu
180 185 190
Met Ala Leu Leu Ser Cys Val Val Asp Tyr Phe Leu Gly His Ser Leu
195 200 205
Glu Phe Asp Gln Ala His Leu Tyr Lys Asp Val Thr Asp Ala Ile Arg
210 215 220
Asp Val His Val Lys Gly Leu Met Tyr Gln Trp Ile Glu Gln Asp Met
225 230 235 240
Glu Lys Tyr Ile Leu Arg Gly Asp Glu Thr Phe Ala Val Leu Ser Arg
245 250 255
Leu Val Ala His Gly Lys Gln Leu Phe Leu Ile Thr Asn Ser Pro Phe
260 265 270
Ser Phe Val Asp Lys Gly Met Arg His Met Val Gly Pro Asp Trp Arg
275 280 285
Gln Leu Phe Asp Val Val Ile Val Gln Ala Asp Lys Pro Ser Phe Phe
290 295 300
Thr Asp Arg Arg Lys Pro Phe Arg Lys Leu Asp Glu Lys Gly Ser Leu
305 310 315 320
Gln Trp Asp Arg Ile Thr Arg Leu Glu Lys Gly Lys Ile Tyr Arg Gln
325 330 335
Gly Asn Leu Phe Asp Phe Leu Arg Leu Thr Glu Trp Arg Gly Pro Arg
340 345 350
Val Leu Tyr Phe Gly Asp His Leu Tyr Ser Asp Leu Ala Asp Leu Met
355 360 365
Leu Arg His Gly Trp Arg Thr Gly Ala Ile Ile Pro Glu Leu Glu Arg
370 375 380
Glu Ile Arg Ile Ile Asn Thr Glu Gln Tyr Met His Ser Leu Thr Trp
385 390 395 400
Gln Gln Ala Leu Thr Gly Leu Leu Glu Arg Met Gln Thr Tyr Gln Asp
405 410 415
Ala Glu Ser Arg Gln Val Leu Ala Ala Trp Met Lys Glu Arg Gln Glu
420 425 430
Leu Arg Cys Ile Thr Lys Ala Leu Phe Asn Ala Gln Phe Gly Ser Ile
435 440 445
Phe Arg Thr Phe His Asn Pro Thr Tyr Phe Ser Arg Arg Leu Val Arg
450 455 460
Phe Ser Asp Leu Tyr Met Ala Ser Leu Ser Cys Leu Leu Asn Tyr Arg
465 470 475 480
Val Asp Phe Thr Phe Tyr Pro Arg Arg Thr Pro Leu Gln His Glu Ala
485 490 495
Pro Leu Trp Met Asp Gln Leu Cys Thr Gly Cys Met Lys Thr Pro Phe
500 505 510
Leu Gly Asp Met Ala His Ile Arg
515 520
<210>135
<211>322
<212>PRT
<213>人
<400>135
Met Ala Arg Cys Phe Ser Leu Val Leu Leu Leu Thr Ser Ile Trp Thr
1 5 10 15
Thr Arg Leu Leu Val Gln Gly Ser Leu Arg Ala Glu Glu Leu Ser Ile
20 25 30
Gln Val Ser Cys Arg Ile Met Gly Ile Thr Leu Val Ser Lys Lys Ala
35 40 45
Asn Gln Gln Leu Asn Phe Thr Glu Ala Lys Glu Ala Cys Arg Leu Leu
50 55 60
Gly Leu Ser Leu Ala Gly Lys Asp Gln Val Glu Thr Ala Leu Lys Ala
65 70 75 80
Ser Phe Glu Thr Cys Ser Tyr Gly Trp Val Gly Asp Gly Phe Val Val
85 90 95
Ile Ser Arg Ile Ser Pro Asn Pro Lys Cys Gly Lys Asn Gly Val Gly
100 105 110
Val Leu ILe Trp Lys Val Pro Val Ser Arg Gln Phe Ala Ala Tyr Cys
115 120 125
Tyr Asn Ser Ser Asp Thr Trp Thr Asn Ser Cys Ile Pro Glu Ile Ile
130 135 140
Thr Thr Lys Asp Pro Ile Phe Asn Thr Gln Thr Ala Thr Gln Thr Thr
145 150 155 160
Glu Phe Ile Val Ser Asp Ser Thr Tyr Ser Val Ala Ser Pro Tyr Ser
165 170 175
Thr Ile Pro Ala Pro Thr Thr Thr Pro Pro Ala Pro Ala Ser Thr Ser
180 185 190
Ile Pro Arg Arg Lys Lys Leu Ile Cys Val Thr Glu Val Phe Met Glu
195 200 205
Thr Ser Thr Met Ser Thr Glu Thr Glu Pro Phe Val Glu Asn Lys Ala
210 215 220
Ala Phe Lys Asn Glu Ala Ala Gly Phe Gly Gly Val Pro Thr Ala Leu
225 230 235 240
Leu Val Leu Ala Leu Leu Phe Phe Gly Ala Ala Ala Gly Leu Gly Phe
245 250 255
Cys Tyr Val Lys Arg Tyr Val Lys Ala Phe Pro Phe Thr Asn Lys Asn
260 265 270
Gln Gln Lys Glu Met Ile Glu Thr Lys Val Val Lys Glu Glu Lys Ala
275 280 285
Asn Asp Ser Asn Pro Asn Glu Glu Ser Lys Lys Thr Asp Lys Asn Pro
290 295 300
Glu Glu Ser Lys Ser Pro Ser Lys Thr Thr Val Arg Cys Leu Glu Ala
305 310 315 320
Glu Val
<210>136
<211>1202
<212>PRT
<213>人
<400>136
Met Gly Arg Glu Gln Asp Leu Ile Leu Ala Val Lys Asn Gly Asp Val
1 5 10 15
Thr Gly Val Gln Lys Leu Val Ala Lys Val Lys Ala Thr Lys Thr Lys
20 25 30
Leu Leu Gly Ser Thr Lys Arg Leu Asn Val Asn Tyr Gln Asp Ala Asp
35 40 45
Gly Phe Ser Ala Leu His His Ala Ala Leu Gly Gly Ser Leu Glu Leu
50 55 60
Ile Ala Leu Leu Leu Glu Ala Gln Ala Thr Val Asp Ile Lys Asp Ser
65 70 75 80
Asn Gly Met Arg Pro Leu His Tyr Ala Ala Trp Gln Gly Arg Leu Glu
85 90 95
Pro Val Arg Leu Leu Leu Arg Ala Ser Ala Ala Val Asn Ala Ala Ser
100 105 110
Leu Asp Gly Gln Ile Pro Leu His Leu Ala Ala Gln Tyr Gly His Tyr
115 120 125
Glu Val Ser Glu Met Leu Leu Gln His Gln Ser Asn Pro Cys Leu Val
130 135 140
Asn Lys Ala Lys Lys Thr Pro Leu Asp Leu Ala Cys Glu Phe Gly Arg
145 150 155 160
Leu Lys ValAla Gln Leu Leu Leu Asn Ser His Leu Cys Val Ala Leu
165 170 175
Leu Glu Gly Glu Ala Lys Asp Pro Cys Asp Pro Asn Tyr Thr Thr Pro
180 185 190
Leu His Leu Ala Ala Lys Asn Gly His Arg Glu Val Ile Arg Gln Leu
195 200 205
Leu Arg Ala Gly Ile Glu Ile Asn Arg Gln Thr Lys Thr Gly Thr Ala
210 215 220
Leu His Glu Ala Ala Leu Tyr Gly Lys Thr Glu Val Val Arg Leu Leu
225 230 235 240
Leu Glu Gly Gly Val Asp Val Asn Ile Arg Asn Thr Tyr Asn Gln Thr
245 250 255
Ala Leu Asp Ile Val Asn Gln Phe Thr Thr Ser Gln Ala Ser Arg Glu
260 265 270
Ile Lys Gln Leu Leu Arg Glu Ala Ser Gly Ile Leu Lys Val Arg Ala
275 280 285
Leu Lys Asp Phe Trp Asn Leu His Asp Pro Thr Ala Leu Asn Val Arg
290 295 300
Ala Gly Asp Val Ile Thr Val Leu Glu Gln His Pro Asp Gly Arg Trp
305 310 315 320
Lys Gly His Ile His Glu Ser Gln Arg Gly Thr Asp Arg Ile Gly Tyr
325 330 335
Phe Pro Pro Gly Ile Val Glu Val Val Ser Lys Arg Val Gly Ile Pro
340 345 350
Ala Ala Arg Leu Pro Ser Ala Pro Thr Pro Leu Arg Pro Gly Phe Ser
355 360 365
Arg Thr Pro Gln Pro Pro Ala Glu Glu Pro Pro His Pro Leu Thr Tyr
370 375 380
Ser Gln Leu Pro Arg Val Gly Leu Ser Pro Asp Ser Pro Ala Gly Asp
385 390 395 400
Arg Asn Ser Val Gly Ser Glu Gly Ser Val Gly Ser Ile Arg Ser Ala
405 410 415
Gly Ser Gly Gln Ser Ser Glu Gly Thr Asn Gly His Gly Pro Gly Leu
420 425 430
Leu Ile Glu Asn Ala Gln Pro Leu Pro Ser Ala Gly Glu Asp Gln Val
435 440 445
Leu Pro Gly Leu His Pro Pro Ser Leu Ala Asp Asn Leu Ser His Arg
450 455 460
Pro Leu Ala Asn Cys Arg Ser Gly Glu Gln Ile Phe Thr Gln Asp Val
465 470 475 480
Arg Pro Glu Gln Leu Leu Glu Gly Lys Asp Ala Gln Ala Ile His Asn
485 490 495
Trp Leu Ser Glu Phe Gln Leu Glu Gly Tyr Thr Ala His Phe Leu Gln
500 505 510
Ala Gly Tyr Asp Val Pro Thr Ile Ser Arg Met Thr Pro Glu Asp Leu
515 520 525
Thr Ala Ile Gly Val Thr Lys Pro Gly His Arg Lys Lys Ile Ala Ser
530 535 540
Glu Ile Ala Gln Leu Ser Ile Ala Glu Trp Leu Pro Ser Tyr Ile Pro
545 550 555 560
Thr Asp Leu Leu Glu Trp Leu Cys Ala Leu Gly Leu Pro Gln Tyr His
565 570 575
Lys Gln Leu Val Ser Ser Gly Tyr Asp Ser Met Gly Leu Val Ala Asp
580 585 590
Leu Thr Trp Glu Glu Leu Gln Glu Ile Gly Val Asn Lys Leu Gly His
595 600 605
Gln Lys Lys Leu Met Leu Gly Val Lys Arg Leu Ala Glu Leu Arg Arg
610 615 620
Gly Leu Leu Gln Gly Glu Ala Leu Ser Glu Gly Gly Arg Arg Leu Ala
625 630 635 640
Lys Gly Pro Glu Leu Met Ala Ile Glu Gly Leu Glu Asn Gly Glu Gly
645 650 655
Pro Ala Thr Ala Gly Pro Arg Leu Leu Thr Phe Gln Gly Ser Glu Leu
660 665 670
Ser Pro Glu Leu Gln Ala Ala Met Ala Gly Gly Gly Pro Glu Pro Leu
675 680 685
Pro Leu Pro Pro Ala Arg Ser Pro Ser Gln Glu Ser Ile Gly Ala Arg
690 695 700
Ser Arg Gly Ser Gly His Ser Gln Glu Gln Pro Ala Pro Gln Pro Ser
705 710 715 720
Gly Gly Asp Pro Ser Pro Pro Gln Glu Arg Asn Leu Pro Glu Gly Thr
725 730 735
Glu Arg Pro Pro Lys Leu Cys Ser Ser Leu Pro Gly Gln Gly Pro Pro
740 745 750
Pro Tyr Val Phe Met Tyr Pro Gln Gly Ser Pro Ser Ser Pro Ala Pro
755 760 765
Gly Pro Pro Pro Gly Ala Pro Trp Ala Phe Ser Tyr Leu Ala Gly Pro
770 775 780
Pro Ala Thr Pro Pro Asp Pro Pro Arg Pro Lys Arg Arg Ser His Ser
785 790 795 800
Leu Ser Arg Pro Gly Pro Thr Glu Gly Asp Ala Glu Gly Glu Ala Glu
805 810 815
Gly Pro Val Gly Ser Thr Leu Gly Ser Tyr Ala Thr Leu Thr Arg Arg
820 825 830
Pro Gly Arg Ser Ala Leu Val Arg Thr Ser Pro Ser ValThr Pro Thr
835 840 845
Pro Ala Arg Gly Thr Pro Arg Ser Gln Ser Phe Ala Leu Arg Ala Arg
850 855 860
Arg Lys Gly Pro Pro Pro Pro Pro Pro Lys Arg Leu Ser Ser Val Ser
865 870 875 880
Gly Pro Ser Pro Glu Pro Pro Pro Leu Asp Gly Ser Pro Gly Pro Lys
885 890 895
Glu Gly Ala Thr Gly Pro Arg Arg Arg Thr Leu Ser Glu Pro Ala Gly
900 905 910
Pro Ser Glu Pro Pro Gly Pro Pro Ala Pro Ala Gly Pro Ala Ser Asp
915 920 925
Thr Glu Glu Glu Glu Pro Gly Pro Glu Gly Thr Pro Pro Ser Arg Gly
930 935 940
Ser Ser Gly Glu Gly Leu Pro Phe Ala Glu Glu Gly Asn Leu Thr Ile
945 950 955 960
Lys Gln Arg Pro Lys Pro Ala Gly Pro Pro Pro Arg Glu Thr Pro Val
965 970 975
Pro Pro Gly Leu Asp Phe Asn Leu Thr Glu Ser Asp Thr Val Lys Arg
980 985 990
Arg Pro Lys Cys Arg Glu Arg Glu Pro Leu Gln Thr Ala Leu Leu Ala
995 1000 1005
Phe Gly Val Ala Ser Ala Thr Pro Gly Pro Ala Ala Pro Leu Pro
1010 1015 1020
Ser Pro Thr Pro Gly Glu Ser Pro Pro Ala Ser Ser Leu Pro Gln
1025 1030 1035
Pro Glu Pro Ser Ser Leu Pro Ala Gln Gly Val Pro Thr Pro Leu
1040 1045 1050
Ala Pro Ser Pro Ala Met Gln Pro Pro Val Pro Pro Cys Pro Gly
1055 1060 1065
Pro Gly Leu Glu Ser Ser Ala Ala Ser Arg Trp Asn Gly Glu Thr
1070 1075 1080
Glu Pro Pro Ala Ala Pro Ala Ala Leu Leu Lys Val Pro Gly Ala
1085 1090 1095
Gly Thr Ala Pro Lys Pro Val Ser Val Ala Cys Thr Gln Leu Ala
1100 1105 1110
Phe Ser Gly Pro Lys Leu Ala Pro Arg Leu Gly Pro Arg Pro Val
1115 1120 1125
Pro Pro Pro Arg Pro Glu Ser Thr Gly Thr Val Gly Pro Gly Gln
1130 1135 1140
Ala Gln Gln Arg Leu Glu Gln Thr Ser Ser Ser Leu Ala Ala Ala
1145 1150 1155
Leu Arg Ala Ala Glu Lys Ser Ile Gly Thr Lys Glu Gln Glu Gly
1160 1165 1170
Thr Pro Ser Ala Ser Thr Lys His Ile Leu Asp Asp Ile Ser Thr
1175 1180 1185
Met Phe Asp Ala Leu Ala Asp Gln Leu Asp Ala Met Leu Asp
1190 1195 1200
<210>137
<211>1496
<212>PRT
<213>人
<400>137
Met Met Ala Asn Trp Ala Glu Ala Arg Pro Leu Leu Ile Leu Ile Val
1 5 10 15
Leu Leu Gly Gln Phe Val Ser Ile Lys Ala Gln Glu Glu Asp Glu Asp
20 25 30
Glu Gly Tyr Gly Glu Glu Ile Ala Cys Thr Gln Asn Gly Gln Met Tyr
35 40 45
Leu Asn Arg Asp Ile Trp Lys Pro Ala Pro Cys Gln Ile Cys ValCys
50 55 60
Asp Asn Gly Ala Ile Leu Cys Asp Lys Ile Glu Cys Gln Asp Val Leu
65 70 75 80
Asp Cys Ala Asp Pro Val Thr Pro Pro Gly Glu Cys Cys Pro Val Cys
85 90 95
Ser Gln Thr Pro Gly Gly Gly Asn Thr Asn Phe Gly Arg Gly Arg Lys
100 105 110
Gly Gln Lys Gly Glu Pro Gly Leu Val Pro Val ValThr Gly Ile Arg
115 120 125
Gly Arg Pro Gly Pro Ala Gly Pro Pro Gly Ser Gln Gly Pro Arg Gly
130 135 140
Glu Arg Gly Pro Lys Gly Arg Pro Gly Pro Arg Gly Pro Gln Gly Ile
145 150 155 160
Asp Gly Glu Pro Gly Val Pro Gly Gln Pro Gly Ala Pro Gly Pro Pro
165 170 175
Gly His Pro Ser His Pro Gly Pro Asp Gly Leu Ser Arg Pro Phe Ser
180 185 190
Ala Gln Met Ala Gly Leu Asp Glu Lys Ser Gly Leu Gly Ser Gln Val
195 200 205
Gly Leu Met Pro Gly Ser Val Gly Pro Val Gly Pro Arg Gly Pro Gln
210 215 220
Gly Leu Gln Gly Gln Gln Gly Gly Ala Gly Pro Thr Gly Pro Pro Gly
225 230 235 240
Glu Pro Gly Asp Pro Gly Pro Met Gly ProIle Gly Ser Arg Gly Pro
245 250 255
Glu Gly Pro Pro Gly Lys Pro Gly Glu Asp Gly Glu Pro Gly Arg Asn
260 265 270
Gly Asn Pro Gly Glu Val Gly Phe Ala Gly Ser Pro Gly Ala Arg Gly
275 280 285
Phe Pro Gly Ala Pro Gly Leu Pro Gly Leu Lys Gly His Arg Gly His
290 295 300
Lys Gly Leu Glu Gly Pro Lys Gly Glu Val Gly Ala Pro Gly Ser Lys
305 310 315 320
Gly Glu Ala Gly Pro Thr Gly Pro Met Gly Ala Met Gly Pro Leu Gly
325 330 335
Pro Arg Gly Met Pro Gly Glu Arg Gly Arg Leu Gly Pro Gln Gly Ala
340 345 350
Pro Gly Gln Arg Gly Ala His Gly Met Pro Gly Lys Pro Gly Pro Met
355 360 365
Gly Pro Leu Gly Ile Pro Gly Ser Ser Gly Phe Pro Gly Asn Pro Gly
370 375 380
Met Lys Gly Glu Ala Gly Pro Thr Gly Ala Arg Gly Pro Glu Gly Pro
385 390 395 400
Gln Gly Gln Arg Gly Glu Thr Gly Pro Pro Gly Pro Val Gly Ser Pro
405 410 415
Gly Leu Pro Gly Ala Ile Gly Thr Asp Gly Thr Pro Gly Pro Lys Gly
420 425 430
Pro Thr Gly Ser Pro Gly Thr Ser Gly Pro Pro Gly Ser Ala Gly Pro
435 440 445
Pro Gly Ser Pro Gly Pro Gln Gly Ser Thr Gly Pro Gln Gly Asn Ser
450 455 460
Gly Leu Pro Gly Asp Pro Gly Phe Lys Gly Glu Ala Gly Pro Lys Gly
465 470 475 480
Glu Pro Gly Pro His Gly Ile Gln Gly Pro Ile Gly Pro Pro Gly Glu
485 490 495
Glu Gly Lys Arg Gly Pro Arg Gly Asp Pro Gly Thr Leu Gly Pro Pro
500 505 510
Gly Pro Val Gly Glu Arg Gly Ala Pro Gly Asn Arg Gly Phe Pro Gly
515 520 525
Ser Asp Gly Leu Pro Gly Pro Lys Gly Ala Gln Gly Glu Arg Gly Pro
530 535 540
Val Gly Ser Ser Gly Pro Lys Gly Ser Gln Gly Asp Pro Gly Arg Pro
545 550 555 560
Gly Glu Pro Gly Leu Pro Gly Ala Arg Gly Leu Thr Gly Asn Pro Gly
565 570 575
Val Gln Gly Pro Glu Gly Lys Leu Gly Pro Leu Gly Ala Pro Gly Glu
580 585 590
Asp Gly Arg Pro Gly Pro Pro Gly Ser Ile Gly Ile Lys Gly Gln Pro
595 600 605
Gly Thr Met Gly Leu Pro Gly Pro Lys Gly Ser Asn Gly Asp Pro Gly
610 615 620
Lys Pro Gly Glu Ala Gly Asn Pro Gly Val Pro Gly Gln Arg Gly Ala
625 630 635 640
Pro Gly Lys Asp Gly Lys Val Gly Pro Tyr Gly Pro Pro Gly Pro Pro
645 650 655
Gly Leu Arg Gly Glu Arg Gly Glu Gln Gly Pro Pro Gly Pro Thr Gly
660 665 670
Phe Gln Gly His Pro Gly Pro Pro Gly Pro Pro Gly Glu Gly Gly Lys
675 680 685
Pro Gly Asp Gln Gly Val Pro Gly Gly Pro Gly Ala Val Gly Pro Leu
690 695 700
Gly Pro Arg Gly Glu Arg Gly Asn Pro Gly Glu Arg Gly Glu Pro Gly
705 710 715 720
Ile Thr Gly Leu Pro Gly Glu Lys Gly Met Ala Gly Gly His Gly Pro
725 730 735
Asp Gly Pro Lys Gly Ser Pro Gly Pro Ser Gly Thr Pro Gly Asp Thr
740 745 750
Gly Pro Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ile Ala Gly
755 760 765
Thr Pro Gly Pro Lys Gly Asp Arg Gly Gly Ile Gly Glu Lys Gly Ala
770 775 780
Glu Gly Thr Ala Gly Asn Asp Gly Ala Gly Gly Leu Pro Gly Pro Leu
785 790 795 800
Gly Pro Pro Gly Pro Ala Gly Leu Leu Gly Glu Lys Gly Glu Pro Gly
805 810 815
Pro Arg Gly Leu Val Gly Pro Pro Gly Ser Arg Gly Asn Pro Gly Ser
820 825 830
Arg Gly Glu Asn Gly Pro Thr Gly Ala Val Gly Phe Ala Gly Pro Gln
835 840 845
Gly Ser Asp Gly Gln Pro Gly ValLys Gly Glu Pro Gly Glu Pro Gly
850 855 860
Gln Lys Gly Asp Ala Gly Ser Pro Gly Pro Gln Gly Leu Ala Gly Ser
865 870 875 880
Pro Gly Pro His Gly Pro Asn Gly Val Pro Gly Leu Lys Gly Gly Arg
885 890 895
Gly Thr Gln Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ser Ala Gly
900 905 910
Arg Val Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Ala Gly Pro
915 920 925
Leu Gly Glu Pro Gly Lys Glu Gly Pro Pro Gly Pro Arg Gly Asp Pro
930 935 940
Gly Ser His Gly Arg Val Gly Val Arg Gly Pro Ala Gly Pro Pro Gly
945 950 955 960
Gly Pro Gly Asp Lys Gly Asp Pro Gly Glu Asp Gly Gln Pro Gly Pro
965 970 975
Asp Gly Pro Pro Gly Pro Ala Gly Thr Thr Gly Gln Arg Gly Ile Val
980 985 990
Gly Met Pro Gly Gln Arg Gly Glu Arg Gly Met Pro Gly Leu Pro Gly
995 1000 1005
Pro Ala Gly Thr Pro Gly Lys Val Gly Pro Thr Gly Ala Thr Gly
1010 1015 1020
Asp Lys Gly Pro Pro Gly Pro Val Gly Pro Pro Gly Ser Asn Gly
1025 1030 1035
Pro Val Gly Glu Pro Gly Pro Glu Gly Pro Ala Gly Asn Asp Gly
1040 1045 1050
Thr Pro Gly Arg Asp Gly Ala Val Gly Glu Arg Gly Asp Arg Gly
1055 1060 1065
Asp Pro Gly Pro Ala Gly Leu Pro Gly Ser Gln Gly Ala Pro Gly
1070 1075 1080
Thr Pro Gly Pro Val Gly Ala Pro Gly Asp Ala Gly Gln Arg Gly
1085 1090 1095
Asp Pro Gly Ser Arg Gly Pro Ile Gly His Leu Gly Arg Ala Gly
1100 1105 1110
Lys Arg Gly Leu Pro Gly Pro Gln Gly Pro Arg Gly Asp Lys Gly
1115 1120 1125
Asp His Gly Asp Arg Gly Asp Arg Gly Gln Lys Gly His Arg Gly
1130 1135 1140
Phe Thr Gly Leu Gln Gly Leu Pro Gly Pro Pro Gly Pro Asn Gly
1145 1150 1155
Glu Gln Gly Ser Ala Gly Ile Pro Gly Pro Phe Gly Pro Arg Gly
1160 1165 1170
Pro Pro Gly Pro Val Gly Pro Ser Gly Lys Glu Gly Asn Pro Gly
1175 1180 1185
Pro Leu Gly Pro Leu Gly Pro Pro Gly Val Arg Gly Ser Val Gly
1190 1195 1200
Glu Ala Gly Pro Glu Gly Pro Pro Gly Glu Pro Gly Pro Pro Gly
1205 1210 1215
Pro Pro Gly Pro Pro Gly His Leu Thr Ala Ala Leu Gly Asp Ile
1220 1225 1230
Met Gly His Tyr Asp Glu Ser Met Pro Asp Pro Leu Pro Glu Phe
1235 1240 1245
Thr Glu Asp Gln Ala Ala Pro Asp Asp Lys Asn Lys Thr Asp Pro
1250 1255 1260
Gly Val His Ala Thr Leu Lys Ser Leu Ser Ser Gln Ile Glu Thr
1265 1270 1275
Met Arg Ser Pro Asp Gly Ser Lys Lys His Pro Ala Arg Thr Cys
1280 1285 1290
Asp Asp Leu Lys Leu Cys His Ser Ala Lys Gln Ser Gly Glu Tyr
1295 1300 1305
Trp Ile Asp Pro Asn Gln Gly Ser ValGlu Asp Ala Ile Lys Val
1310 1315 1320
Tyr Cys Asn Met Glu Thr Gly Glu Thr Cys Ile Ser Ala Asn Pro
1325 1330 1335
Ser Ser Val Pro Arg Lys Thr Trp Trp Ala Ser Lys Ser Pro Asp
1340 1345 1350
Asn Lys Pro Val Trp Tyr Gly Leu Asp Met Asn Arg Gly Ser Gln
1355 1360 1365
Phe Ala Tyr Gly Asp His Gln Ser Pro Asn Thr Ala Ile Thr Gln
1370 1375 1380
Met Thr Phe Leu Arg Leu Leu Ser Lys Glu Ala Ser Gln Asn Ile
1385 1390 1395
Thr Tyr Ile Cys Lys Asn Ser Val Gly Tyr Met Asp Asp Gln Ala
1400 1405 1410
Lys Asn Leu Lys Lys Ala Val Val Leu Lys Gly Ala Asn Asp Leu
1415 1420 1425
Asp Ile Lys Ala Glu Gly Asn Ile Arg Phe Arg Tyr Ile Val Leu
1430 1435 1440
Gln Asp Thr Cys Ser Lys Arg Asn Gly Asn Val Gly Lys Thr Val
1445 1450 1455
Phe Glu Tyr Arg Thr Gln Asn Val Ala Arg Leu Pro Ile Ile Asp
1460 1465 1470
Leu Ala Pro Val Asp Val Gly Gly Thr Asp Gln Glu Phe Gly Val
1475 1480 1485
Glu Ile Gly Pro Val Cys Phe Val
1490 1495
<210>138
<211>726
<212>PRT
<213>人
<400>138
Met Ser Thr Ala Thr Thr Val Ala Pro Ala Gly Ile Pro Ala Thr Pro
1 5 10 15
Gly Pro Val Asn Pro Pro Pro Pro Glu Val Ser Asn Pro Ser Lys Pro
20 25 30
Gly Arg Lys Thr Asn Gln Leu Gln Tyr Met Gln Asn Val Val Val Lys
35 40 45
Thr Leu Trp Lys His Gln Phe Ala Trp Pro Phe Tyr Gln Pro Val Asp
50 55 60
Ala Ile Lys Leu Asn Leu Pro Asp Tyr His LysIle Ile Lys Asn Pro
65 70 75 80
Met Asp Met Gly Thr Ile Lys Lys Arg Leu Glu Asn Asn Tyr Tyr Trp
85 90 95
Ser Ala Ser Glu Cys Met Gln Asp Phe Asn Thr Met Phe Thr Asn Cys
100 105 110
Tyr Ile Tyr Asn Lys Pro Thr Asp Asp Ile Val Leu Met Ala Gln Ala
115 120 125
Leu Glu Lys Ile Phe Leu Gln Lys Val Ala Gln Met Pro Gln Glu Glu
130 135 140
Val Glu Leu Leu Pro Pro Ala Pro Lys Gly Lys Gly Arg Lys Pro Ala
145 150 155 160
Ala Gly Ala Gln Ser Ala Gly Thr Gln Gln Val Ala Ala Val Ser Ser
165 170 175
Val Ser Pro Ala Thr Pro Phe Gln Ser Val Pro Pro Thr Val Ser Gln
180 185 190
Thr Pro Val Ile Ala Ala Thr Pro Val Pro Thr Ile Thr Ala Asn Val
195 200 205
Thr Ser Val Pro Val Pro Pro Ala Ala Ala Pro Pro Pro Pro Ala Thr
210 215 220
Pro Ile Val Pro Val Val Pro Pro Thr Pro Pro Val Val Lys Lys Lys
225 230 235 240
Gly Val Lys Arg Lys Ala Asp Thr Thr Thr Pro Thr Thr Ser Ala Ile
245 250 255
Thr Ala Ser Arg Ser Glu Ser Pro Pro Pro Leu Ser Asp Pro Lys Gln
260 265 270
Ala Lys Val Val Ala Arg Arg Glu Ser Gly Gly Arg Pro Ile Lys Pro
275 280 285
Pro Lys Lys Asp Leu Glu Asp Gly Glu Val Pro Gln His Ala Gly Lys
290 295 300
Lys Gly Lys Leu Ser Glu His Leu Arg Tyr Cys Asp Ser Ile Leu Arg
305 310 315 320
Glu Met Leu Ser Lys Lys His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys
325 330 335
Pro Val Asp Ala Glu Ala Leu Glu Leu His Asp Tyr His Asp Ile Ile
340 345 350
Lys His Pro Met Asp Leu Ser Thr Val Lys Arg Lys Met Asp Gly Arg
355 360 365
Glu Tyr Pro Asp Ala Gln Gly Phe Ala Ala Asp Val Arg Leu Met Phe
370 375 380
Ser Asn Cys Tyr Lys Tyr Asn Pro Pro Asp His Glu Val Val Ala Met
385 390 395 400
Ala Arg Lys Leu Gln Asp Val Phe Glu Met Arg Phe Ala Lys Met Pro
405 410 415
Asp Glu Pro Val Glu Ala Pro Ala Leu Pro Ala Pro Ala Ala Pro Met
420 425 430
Val Ser Lys Gly Ala Glu Ser Ser Arg Ser Ser Glu Glu Ser Ser Ser
435 440 445
Asp Ser Gly Ser Ser Asp Ser Glu Glu Glu Arg Ala Thr Arg Leu Ala
450 455 460
Glu Leu Gln Glu Gln Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu
465 470 475 480
Ser Gln Ala Pro Val Asn Lys Pro Lys Lys Lys Lys Glu Lys Lys Glu
485 490 495
Lys Glu Lys Lys Lys Lys Asp Lys Glu Lys Glu Lys Glu Lys His Lys
500 505 510
Val Lys Ala Glu Glu Glu Lys Lys Ala Lys Val Ala Pro Pro Ala Lys
515 520 525
Gln Ala Gln Gln Lys Lys Ala Pro Ala Lys Lys Ala Asn Ser Thr Thr
530 535 540
Thr Ala Gly Arg Gln Leu Lys Lys Gly Gly Lys Gln Ala Ser Ala Ser
545 550 555 560
Tyr Asp Ser Glu Glu Glu Glu Glu Gly Leu Pro Met Ser Tyr Asp Glu
565 570 575
Lys Arg Gln Leu Ser Leu Asp Ile Asn Arg Leu Pro Gly Glu Lys Leu
580 585 590
Gly Arg Val Val His Ile Ile Gln Ser Arg Glu Pro Ser Leu Arg Asp
595 600 605
Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe Glu Thr Leu Lys Pro Thr
610 615 620
Thr Leu Arg Glu Leu Glu Arg Tyr Val Lys Ser Cys Leu Gln Lys Lys
625 630 635 640
Gln Arg Lys Pro Phe Ser Ala Ser Gly Lys Lys Gln Ala Ala Lys Ser
645 650 655
Lys Glu Glu Leu Ala Gln Glu Lys Lys Lys Glu Leu Glu Lys Arg Leu
660 665 670
Gln Asp Val Ser Gly Gln Leu Ser Ser Ser Lys Lys Pro Ala Arg Lys
675 680 685
Glu Lys Pro Gly Ser Ala Pro Ser Gly Gly Pro Ser Arg Leu Ser Ser
690 695 700
Ser Ser Ser Ser Glu Ser Gly Ser Ser Ser Ser Ser Gly Ser Ser Ser
705 710 715 720
Asp Ser Ser Asp Ser Glu
725
<210>139
<211>840
<212>PRT
<213>人
<400>139
Met Ala Ser Val Phe Arg Ser Glu Glu Met Cys Leu Ser Gln Leu Phe
1 5 10 15
Leu Gln Val Glu Ala Ala Tyr Cys Cys Val Ala Glu Leu Gly Glu Leu
20 25 30
Gly Leu Val Gln Phe Lys Asp Leu Asn Met Asn Val Asn Ser Phe Gln
35 40 45
Arg Lys Phe Val Asn Glu Val Arg Arg Cys Glu Ser Leu Glu Arg Ile
50 55 60
Leu Arg Phe Leu Glu Asp Glu Met Gln Asn Glu Ile Val Val Gln Leu
65 70 75 80
Leu Glu Lys Ser Pro Leu Thr Pro Leu Pro Arg Glu Met Ile Thr Leu
85 90 95
Glu Thr Val Leu Glu Lys Leu Glu Gly Glu Leu Gln Glu Ala Asn Gln
100 105 110
Asn Gln Gln Ala Leu Lys Gln Ser Phe Leu Glu Leu Thr Glu Leu Lys
115 120 125
Tyr Leu Leu Lys Lys Thr Gln Asp Phe Phe Glu Thr Glu Thr Asn Leu
130 135 140
Ala Asp Asp Phe Phe Thr Glu Asp Thr Ser Gly Leu Leu Glu Leu Lys
145 150 155 160
Ala Val Pro Ala Tyr Met Thr Gly Lys Leu Gly Phe Ile Ala Gly Val
165 170 175
Ile Asn Arg Glu Arg Met Ala Ser Phe Glu Arg Leu Leu Trp Arg Ile
180 185 190
Cys Arg Gly Asn Val Tyr Leu Lys Phe Ser Glu Met Asp Ala Pro Leu
195 200 205
Glu Asp Pro Val Thr Lys Glu Glu Ile Gln Lys Asn Ile Phe Ile Ile
210 215 220
Phe Tyr Gln Gly Glu Gln Leu Arg Gln Lys Ile Lys Lys Ile Cys Asp
225 230 235 240
Gly Phe Arg Ala Thr Val Tyr Pro Cys Pro Glu Pro Ala Val Glu Arg
245 250 255
Arg Glu Met Leu Glu Ser Val Asn Val Arg Leu Glu Asp Leu Ile Thr
260 265 270
Val Ile Thr Gln Thr Glu Ser His Arg Gln Arg Leu Leu Gln Glu Ala
275 280 285
Ala Ala Asn Trp His Ser Trp Leu Ile Lys Val Gln Lys Met Lys Ala
290 295 300
Val Tyr His Ile Leu Asn Met Cys Asn Ile Asp Val Thr Gln Gln Cys
305 310 315 320
Val Ile Ala Glu Ile Trp Phe Pro Val Ala Asp Ala Thr Arg Ile Lys
325 330 335
Arg Ala Leu Glu Gln Gly Met Glu Leu Ser Gly Ser Ser Met Ala Pro
340 345 350
Ile Met Thr Thr Val Gln Ser Lys Thr Ala Pro Pro Thr Phe Asn Arg
355 360 365
Thr Asn Lys Phe Thr Ala Gly Phe Gln Asn Ile Val Asp Ala Tyr Gly
370 375 380
Val Gly Ser Tyr Arg Glu Ile Asn Pro Ala Pro Tyr Thr Ile Ile Thr
385 390 395 400
Phe Pro Phe Leu Phe Ala Val Met Phe Gly Asp Cys Gly His Gly Thr
405 410 415
Val Met Leu Leu Ala Ala Leu Trp Met Ile Leu Asn Glu Arg Arg Leu
420 425 430
Leu Ser Gln Lys Thr Asp Asn Glu Ile Trp Asn Thr Phe Phe His Gly
435 440 445
Arg Tyr Leu Ile Leu Leu Met Gly Ile Phe Ser Ile Tyr Thr Gly Leu
450 455 460
Ile Tyr Asn Asp Cys Phe Ser Lys Ser Leu Asn Ile Phe Gly Ser Ser
465 470 475 480
Trp Ser Val Gln Pro Met Phe Arg Asn Gly Thr Trp Asn Thr His Val
485 490 495
Met Glu Glu Ser Leu Tyr Leu Gln Leu Asp Pro Ala Ile Pro Gly Val
500 505 510
Tyr Phe Gly Asn Pro Tyr Pro Phe Gly Ile Asp Pro Ile Trp Asn Leu
515 520 525
Ala Ser Asn Lys Leu Thr Phe Leu Asn Ser Tyr Lys Met Lys Met Ser
530 535 540
Val Ile Leu Gly Ile Val Gln Met Val Phe Gly Val Ile Leu Ser Leu
545 550 555 560
Phe Asn His Ile Tyr Phe Arg Arg Thr Leu Asn Ile Ile Leu Gln Phe
565 570 575
Ile Pro Glu Met Ile Phe Ile Leu Cys Leu Phe Gly Tyr Leu Val Phe
580 585 590
Met Ile Ile Phe Lys Trp Cys Cys Phe Asp Val His Val Ser Gln His
595 600 605
Ala Pro Ser Ile Leu Ile His Phe Ile Asn Met Phe Leu Phe Asn Tyr
610 615 620
Ser Asp Ser Ser Asn Ala Pro Leu Tyr Lys His Gln Gln Glu Val Gln
625 630 635 640
Ser Phe Phe Val Val Met Ala Leu Ile Ser Val Pro Trp Met Leu Leu
645 650 655
Ile Lys Pro Phe Ile Leu Arg Ala Ser His Arg Lys Ser Gln Leu Gln
660 665 670
Ala Ser Arg Ile Gln Glu Asp Ala Thr Glu Asn Ile Glu Gly Asp Ser
675 680 685
Ser Ser Pro Ser Ser Arg Ser Gly Gln Arg Thr Ser Ala Asp Thr His
690 695 700
Gly Ala Leu Asp Asp His Gly Glu Glu Phe Asn Phe Gly Asp Val Phe
705 710 715 720
Val His Gln Ala Ile His Thr Ile Glu Tyr Cys Leu Gly Cys Ile Ser
725 730 735
Asn Thr Ala Ser Tyr Leu Arg Leu Trp Ala Leu Ser Leu Ala His Ala
740 745 750
Gln Leu Ser Glu Val Leu Trp Thr Met Val Met Asn Ser Gly Leu Gln
755 760 765
Thr Arg Gly Trp Gly Gly Ile Val Gly Val Phe Ile Ile Phe Ala Val
770 775 780
Phe Ala Val Leu Thr Val Ala Ile Leu Leu Ile Met Glu Gly Leu Ser
785 790 795 800
Ala Phe Leu His Ala Leu Arg Leu His Trp Val Glu Phe Gln Asn Lys
805 810 815
Phe Tyr Val Gly Asp Gly Tyr Lys Phe Ser Pro Phe Ser Phe Lys His
820 825 830
Ile Leu Asp Gly Thr Ala Glu Glu
835 840
<210>140
<211>826
<212>PRT
<213>人
<400>140
Pro Ser Gly Leu Pro Leu Leu Pro Val Leu Phe Ala Leu Gly Gly Leu
1 5 10 15
Leu Leu Leu Ser Asn Ala Ser Cys Val Gly Gly Val Leu Trp Gln Arg
20 25 30
Arg Leu Arg Arg Leu Ala Glu Ala Leu Asn Phe Pro Pro His Leu His
35 40 45
Pro Gly Arg Ser Glu Glu Asp Arg Val Arg Asn Glu Tyr Glu Glu Ser
50 55 60
Gln Trp Thr Gly Glu Arg Asp Thr Gln Ser Ser Thr Val Ser Thr Thr
65 70 75 80
Glu Ala Glu Pro Tyr Tyr Arg Ser Leu Arg Asp Phe Ser Pro Gln Leu
85 90 95
Pro Pro Thr Gln Glu Glu Val Ser Tyr Ser Arg Gly Phe Thr Gly Glu
100 105 110
Asp Glu Asp Met Ala Phe Pro Gly His Leu Tyr Asp Glu Val Glu Arg
115 120 125
Thr Tyr Pro Pro Ser Gly Ala Trp Gly Pro Leu Tyr Asp Glu Val Gln
130 135 140
Met Gly Pro Trp Asp Leu His Trp Pro Glu Asp Thr Tyr Gln Asp Pro
145 150 155 160
Arg Gly Ile Tyr Asp Gln Val Ala Gly Asp Leu Asp Thr Leu Glu Pro
165 170 175
Asp Ser Leu Pro Phe Glu Leu Arg Gly His Leu Val Trp Gly Phe Asn
180 185 190
His Val Ser Gln Ala Gly Leu Lys Leu Leu Ala Ser Ser Asp Pro Pro
195 200 205
Ala Ser Ala Ser Gln Ser Ala Glu Ile Thr Glu Ser His Ser Val Val
210 215 220
Gln Val Gly Val Gln Trp Arg Tyr Phe Gly Ser Leu His Pro Leu Pro
225 230 235 240
Pro Gly Ser Arg Asp Ser Leu Ala Ser Ala Ser Arg Ile Ala Gly Ile
245 250 255
Thr Ala Pro Trp Glu Ala Glu Val Ser Arg Ser Pro Gln Gly Thr Gln
260 265 270
Asp Ser Pro Val Thr Arg Ser Gly Pro Pro Ser Arg Gly Trp Gln Ser
275 280 285
Leu Ser Phe Asp Gly Gly Ala Phe His Leu Lys Gly Thr Gly Glu Leu
290 295 300
Thr Arg Ala Leu Leu Val Leu Arg Leu Cys Ala Trp Pro Pro Leu Val
305 310 315 320
Thr His Gly Leu Leu Leu Gln Ala Trp Ser Arg Arg Leu Leu Gly Ser
325 330 335
Arg Leu Ser Gly Ala Phe Leu Arg Ala Ser Val Tyr Gly Gln Phe Val
340 345 350
Ala Gly Glu Thr Ala Glu Glu Val Lys Gly Cys Val Gln Gln Leu Arg
355 360 365
Thr Leu Ser Leu Arg Pro Leu Leu Ala Val Pro Thr Glu Glu Glu Pro
370 375 380
Asp Ser Ala Ala Lys Arg Met Arg Leu His His Val Gly Gln Ala Gly
385 390 395 400
Leu Glu Leu Leu Thr Pro Ala Ala Ser Gly Ser Val Ala Gln Ala Gly
405 410 415
Val Gln Trp Arg Gln Ser Ser Asp Arg Gly Gly Gly Asn Gln Ala Ala
420 425 430
Ala Ser Arg Ser Ser Leu Leu Gln Glu Ala Ala Phe Ser Pro Pro Cys
435 440 445
Gly Arg Leu Gln Leu Pro Ala Gln Pro Ala Ser Arg His Gly Ala Arg
450 455 460
Gly Arg Gly Ser Met Lys Ala Lys Ser Leu Thr Ser Arg His Leu Leu
465 470 475 480
Ala Ser Gln Gly Gln Glu Thr Ile Ile Lys Thr Lys Val Arg Ile Pro
485 490 495
Ala Leu Trp Lys Ala Glu Pro Gly Gln His Ser Lys Thr Pro Ser Gln
500 505 510
Gln Asn Lys Ser Gln Tyr Val Thr Thr Leu Trp Glu Ala Asp Val Gly
515 520 525
Arg Ser Leu Glu Asn Leu Gln Val Ser Cys Leu Asn Ala Glu Gln Asn
530 535 540
Gln His Leu Arg Ala Ser Leu Ser Arg Leu His Arg Val Thr Pro Pro
545 550 555 560
Ala Gly Thr Ser Thr Ser Gly Pro Pro Ser Ala Ala Cys Ile Gly Trp
565 570 575
His Ser Arg Leu His Arg Val Ala Gln Tyr Ala Arg Ala Gln His Val
580 585 590
Arg Leu Leu Val Asp Ala Glu Tyr Thr Ser Leu Asn Pro Ala Leu Ser
595 600 605
Leu Leu Val Ala Ala Leu Ala Val Arg Trp Asn Ser Pro Gly Glu Gly
610 615 620
Gly Pro Trp Val Trp Asn Thr Tyr Gln Ala Cys Leu Lys Asp Thr Phe
625 630 635 640
Glu Arg Leu Gly Arg Asp Ala Glu Ala Ala His Arg Ala Gly Leu Ala
645 650 655
Phe Gly Val Lys Leu Val Arg Gly Ala Tyr Leu Asp Lys Glu Arg Ala
660 665 670
Val Ala Gln Leu His Gly Met Glu Asp Pro Thr Gln Pro Asp Tyr Glu
675 680 685
Ala Thr Ser Glu Leu Asn Arg Ala Ser Pro Phe Ser Tyr Ser Arg Cys
690 695 700
Leu Glu Leu Met Leu Thr His Val Ala Arg His Gly Pro Met Cys His
705 710 715 720
Leu Met Val Ala Ser His Asn Glu Glu Ser Val Arg Gln Ala Thr Lys
725 730 735
Arg Met Trp Glu Leu Gly Ile Pro Leu Asp Gly Thr Val Cys Phe Gly
740 745 750
Gln Leu Leu Gly Met Cys Asp His Val Ser Leu Ala Leu Gly Gln Ala
755 760 765
Gly Tyr Val Val Tyr Lys Ser Ile Pro Tyr Gly Ser Leu Glu Glu Val
770 775 780
Ile Pro Tyr Leu Ile Arg Arg Ala Gln Glu Asn Arg Ser Val Leu Gln
785 790 795 800
Gly Ala Arg Arg Glu Gln Glu Leu Leu Ser Gln Glu Leu Trp Arg Arg
805 810 815
Leu Leu Pro Gly Cys Arg Arg Ile Pro His
820 825
<210>141
<211>987
<212>PRT
<213>人
<400> 141
Met Ala Leu Arg Arg Leu Gly Ala Ala Leu Leu Leu Leu Pro Leu Leu
1 5 10 15
Ala Ala Val Glu Glu Thr Leu Met Asp Ser Thr Thr Ala Thr Ala Glu
20 25 30
Leu Gly Trp Met Val His Pro Pro Ser Gly Trp Glu Glu Val Ser Gly
35 40 45
Tyr Asp Glu Asn Met Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val
50 55 60
Phe Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Lys Phe Ile Arg Arg
65 70 75 80
Arg Gly Ala His Arg Ile His Val Glu Met Lys Phe Ser Val Arg Asp
85 90 95
Cys Ser Ser Ile Pro Ser Val Pro Gly Ser Cys Lys Glu Thr Phe Asn
100 105 110
Leu Tyr Tyr Tyr Glu Ala Asp Phe Asp Ser Ala Thr Lys Thr Phe Pro
115 120 125
Asn Trp Met Glu Asn Pro Trp Val Lys Val Asp Thr Ile Ala Ala Asp
130 135 140
Glu Ser Phe Ser Gln Val Asp Leu Gly Gly Arg Val Met Lys Ile Asn
145 150 155 160
Thr Glu ValArg Ser Phe Gly Pro Val Ser Arg Ser Gly Phe Tyr Leu
165 170 175
Ala Phe Gln Asp Tyr Gly Gly Cys Met Ser Leu Ile Ala Val Arg Val
180 185 190
Phe Tyr Arg Lys Cys Pro Arg Ile Ile Gln Asn Gly Ala Ile Phe Gln
195 200 205
Glu Thr Leu Ser Gly Ala Glu Ser Thr Ser Leu Val Ala Ala Arg Gly
210 215 220
Ser Cys Ile Ala Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr
225 230 235 240
Cys Asn Gly Asp Gly Glu Trp Leu Val Pro Ile Gly Arg Cys Met Cys
245 250 255
Lys Ala Gly Phe Glu Ala Val Glu Asn Gly Thr Val Cys Arg Gly Cys
260 265 270
Pro Ser Gly Thr Phe Lys Ala Asn Gln Gly Asp Glu Ala Cys Thr His
275 280 285
Cys Pro Ile Asn Ser Arg Thr Thr Ser Glu Gly Ala Thr Asn Cys Val
290 295 300
Cys Arg Asn Gly Tyr Tyr Arg Ala Asp Leu Asp Pro Leu Asp Met Pro
305 310 315 320
Cys Thr Thr Ile Pro Ser Ala Pro Gln Ala Val Ile Ser Ser Val Asn
325 330 335
Glu Thr Ser Leu Met Leu Glu Trp Thr Pro Pro Arg Asp Ser Gly Gly
340 345 350
Arg Glu Asp Leu Val Tyr Asn Ile Ile Cys Lys Ser Cys Gly Ser Gly
355 360 365
Arg Gly Ala Cys Thr Arg Cys Gly Asp Asn Val Gln Tyr Ala Pro Arg
370 375 380
Gln Leu Gly Leu Thr Glu Pro Arg Ile Tyr Ile Ser Asp Leu Leu Ala
385 390 395 400
His Thr Gln Tyr Thr Phe Glu Ile Gln Ala Val Asn Gly Val Thr Asp
405 410 415
Gln Ser Pro Phe Ser Pro Gln Phe Ala Ser Val Asn Ile Thr Thr Asn
420 425 430
Gln Ala Ala Pro Ser Ala Val Ser Ile Met His Gln Val Ser Arg Thr
435 440 445
Val Asp Ser Ile Thr Leu Ser Trp Ser Gln Pro Asp Gln Pro Asn Gly
450 455 460
Val Ile Leu Asp Tyr Glu Leu Gln Tyr Tyr Glu Lys Glu Leu Ser Glu
465 470 475 480
Tyr Asn Ala Thr Ala Ile Lys Ser Pro Thr Asn Thr Val Thr Val Gln
485 490 495
Gly Leu Lys Ala Gly Ala Ile Tyr Val Phe Gln Val Arg Ala Arg Thr
500 505 510
Val Ala Gly Tyr Gly Arg Tyr Ser Gly Lys Met Tyr Phe Gln Thr Met
515 520 525
Thr Glu Ala Glu Tyr Gln Thr Ser Ile Gln Glu Lys Leu Pro Leu Ile
530 535 540
Ile Gly Ser Ser Ala Ala Gly Leu ValPhe Leu Ile Ala Val Val Val
545 550 555 560
Ile Ala Ile Val Cys Asn Arg Arg Arg Gly Phe Glu Arg Ala Asp Ser
565 570 575
Glu Tyr Thr Asp Lys Leu Gln His Tyr Thr Ser Gly His Met Thr Pro
580 585 590
Gly Met Lys Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu
595 600 605
Ala Val Arg Glu Phe Ala Lys Glu Ile Asp Ile Ser Cys Val Lys Ile
610 615 620
Glu Gln Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly His
625 630 635 640
Leu Lys Leu Pro Gly Lys Arg Glu Ile Phe Val Ala Ile Lys Thr Leu
645 650 655
Lys Ser Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala
660 665 670
Ser Ile Met Gly Gln Phe Asp His Pro Asn Val Ile His Leu Glu Gly
675 680 685
Val Val Thr Lys Ser Thr Pro Val Met Ile Ile Thr Glu Phe Met Glu
690 695 700
Asn Gly Ser Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr
705 710 715 720
Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys
725 730 735
Tyr Leu Ala Asp Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn
740 745 750
Ile Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu
755 760 765
Ser Arg Phe Leu Glu Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ala
770 775 780
Leu Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Gln
785 790 795 800
Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val
805 810 815
Met Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Thr
820 825 830
Asn Gln Asp Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro
835 840 845
Pro Met Asp Cys Pro Ser Ala Leu His Gln Leu Met Leu Asp Cys Trp
850 855 860
Gln Lys Asp Arg Asn His Arg Pro Lys Phe Gly Gln Ile Val Asn Thr
865 870 875 880
Leu Asp Lys Met Ile Arg Asn Pro Asn Ser Leu Lys Ala Met Ala Pro
885 890 895
Leu Ser Ser Gly Ile Asn Leu Pro Leu Leu Asp Arg Thr Ile Pro Asp
900 905 910
Tyr Thr Ser Phe Asn Thr Val Asp Glu Trp Leu Glu Ala Ile Lys Met
915 920 925
Gly Gln Tyr Lys Glu Ser Phe Ala Asn Ala Gly Phe Thr Ser Phe Asp
930 935 940
Val Val Ser Gln Met Met Met Glu Asp Ile Leu Arg Val Gly Val Thr
945 950 955 960
Leu Ala Gly His Gln Lys Lys Ile Leu Asn Ser Ile Gln Val Met Arg
965 970 975
Ala Gln Met Asn Gln Ile Gln Ser Val Glu Val
980 985
<210>142
<211>379
<212>PRT
<213>人
<400>142
Met Val Phe Phe Thr Cys Asn Ala Cys Gly Glu Ser Val Lys Lys Ile
1 5 10 15
Gln Val Glu Lys His Val Ser Val Cys Arg Asn Cys Glu Cys Leu Ser
20 25 30
Cys Ile Asp Cys Gly Lys Asp Phe Trp Gly Asp Asp Tyr Lys Asn His
35 40 45
Val Lys Cys Ile Ser Glu Asp Gln Lys Tyr Gly Gly Lys Gly Tyr Glu
50 55 60
Gly Lys Thr His Lys Gly Asp Ile Lys Gln Gln Ala Trp Ile Gln Lys
65 70 75 80
Ile Ser Glu Leu Ile Lys Arg Pro Asn Val Ser Pro Lys Val Arg Glu
85 90 95
Leu Leu Glu Gln Ile Ser Ala Phe Asp Asn Val Pro Arg Lys Lys Ala
100 105 110
Lys Phe Gln Asn Trp Met Lys Asn Ser Leu Lys Val His Asn Glu Ser
115 120 125
Ile Leu Asp Gln Val Trp Asn Ile Phe Ser Glu Ala Ser Asn Ser Glu
130 135 140
Pro Val Asn Lys Glu Gln Asp Gln Arg Pro Leu His Pro Val Ala Asn
145 150 155 160
Pro His Ala Glu Ile Ser Thr Lys Val Pro Ala Ser Lys Val Lys Asp
165 170 175
Ala Val Glu Gln Gln Gly Glu Val Lys Lys Asn Lys Arg Glu Arg Lys
180 185 190
Glu Glu Arg Gln Lys Lys Arg Lys Arg Glu Lys Lys Glu Leu Lys Leu
195 200 205
Glu Asn His Gln Glu Asn Ser Arg Asn Gln Lys Pro Lys Lys Arg Lys
210 215 220
Lys Gly Gln Glu Ala Asp Leu Glu Ala Gly Gly Glu Glu Val Pro Glu
225 230 235 240
Ala Asn Gly Ser Ala Gly Lys Arg Ser Lys Lys Lys Lys Gln Arg Lys
245 250 255
Asp Ser Ala Ser Glu Glu Glu Ala Arg Val Gly Ala Gly Lys Arg Lys
260 265 170
Arg Arg His Ser Glu Val Glu Thr Asp Ser Lys Lys Lys Lys Met Lys
275 280 285
Leu Pro Glu His Pro Glu Gly Gly Glu Pro Glu Asp Asp Glu Ala Pro
290 295 300
Ala Lys Gly Lys Phe Asn Trp Lys Gly Thr Ile Lys Ala Ile Leu Lys
305 310 315 320
Gln Ala Pro Asp Asn Glu Ile Thr Ile Lys Lys Leu Arg Lys Lys Val
325 330 335
Leu Ala Gln Tyr Tyr Thr Val Thr Asp Glu His His Arg Ser Glu Glu
340 345 350
Glu Leu Leu Val Ile Phe Asn Lys Lys Ile Ser Lys Asn Pro Thr Phe
355 360 365
Lys Leu Leu Lys Asp Lys Val Lys Leu Val Lys
370 375
<210>143
<211>86
<212>PRT
<213>人
<400>143
Met Ala Glu Asp Met Glu Thr Lys Ile Lys Asn Tyr Lys Thr Ala Pro
1 5 10 15
Phe Asp Ser Arg Phe Pro Asn Gln Asn Gln Thr Arg Asn Cys Trp Gln
20 25 30
Asn Tyr Leu Asp Phe His Arg Cys Gln Lys Ala Met Thr Ala Lys Gly
35 40 45
Gly Asp Ile Ser Val Cys Glu Trp Tyr Gln Arg Val Tyr Gln Ser Leu
50 55 60
Cys Pro Thr Ser Trp Val Thr Asp Trp Asp Glu Gln Arg Ala Glu Gly
65 70 75 80
Thr Phe Pro Gly Lys Ile
85
<210>144
<211>166
<212>PRT
<213>人
<400>144
Met Leu Leu Ile Leu Leu Ser Val Ala Leu Leu Ala Phe Ser Ser Ala
1 5 10 15
Gln Asp Leu Asn Glu Asp Val Ser Gln Glu Asp Val Pro Leu Val Ile
20 25 30
Ser Asp Gly Gly Asp Ser Glu Gln Phe Ile Asp Glu Glu Arg Gln Gly
35 40 45
Pro Pro Leu Gly Gly Gln Gln Ser Gln Pro Ser Ala Gly Asp Gly Asn
50 55 60
Gln Asp Asp Gly Pro Gln Gln Gly Pro Pro Gln Gln Gly Gly Gln Gln
65 70 75 80
Gln Gln Gly Pro Pro Pro Pro Gln Gly Lys Pro Gln Gly Pro Pro Gln
85 90 95
Gln Gly Gly His Pro Pro Pro Pro Gln Gly Arg Pro Gln Gly Pro Pro
100 105 110
Gln Gln Gly Gly His Pro Arg Pro Pro Arg Gly Arg Pro Gln Gly Pro
115 120 125
Pro Gln Gln Gly Gly His Gln Gln Gly Pro Pro Pro Pro Pro Pro Gly
130 135 140
Lys Pro Gln Gly Pro Pro Pro Gln Gly Gly Arg Pro Gln Gly Pro Pro
145 150 155 160
Gln Gly Gln Ser Pro Gln
165
<210>145
<211>262
<212>PRT
<213>人
<400>145
Met Asp Pro Arg Leu Ser Thr Val Arg Gln Thr Cys Cys Cys Phe Asn
5 10 15
Val Arg Ile Ala Thr Thr Ala Leu Ala Ile Tyr His Val Ile Met Ser
20 25 30
Val Leu Leu Phe Ile Glu His Ser Val Glu Val Ala His Gly Lys Ala
35 40 45
Ser Cys Lys Leu Ser Gln Met Gly Tyr Leu Arg Ile Ala Asp Leu Ile
50 55 60
Ser Ser Phe Leu Leu Ile Thr Met Leu Phe Ile Ile Ser Leu Ser Leu
65 70 75 80
Leu Ile Gly Val Val Lys Asn Arg Glu Lys Tyr Leu Leu Pro Phe Leu
85 90 95
Ser Leu Gln Ile Met Asp Tyr Leu Leu Cys Leu Leu Thr Leu Leu Gly
100 105 110
Ser Tyr Ile Glu Leu Pro Ala Tyr Leu Lys Leu Ala Ser Arg Ser Arg
115 120 125
Ala Ser Ser Ser Lys Phe Pro Leu Met Thr Leu Gln Leu Leu Asp Phe
130 135 140
Cys Leu Ser Ile Leu Thr Leu Cys Ser Ser Tyr Met Glu Val Pro Thr
145 150 155 160
Tyr Leu Asn Phe Lys Ser Met Asn His Met Asn Tyr Leu Pro Ser Gln
165 170 175
Glu Asp Met Pro His Asn Gln Phe Ile Lys Met Met Ile Ile Phe Ser
180 185 190
Ile Ala Phe Ile Thr Val Leu Ile Phe Lys Val Tyr Met Phe Lys Cys
195 200 205
Val Trp Arg Cys Tyr Arg Leu Ile Lys Cys Met Asn Ser Val Glu Glu
210 215 220
Lys Arg Asn Ser Lys Met Leu Gln Lys Val Val Leu Pro Ser Tyr Glu
225 230 235 240
Glu Ala Leu Ser Leu Pro Ser Lys Thr Pro Glu Gly Gly Pro Ala Pro
245 250 255
Pro Pro Tyr Ser Glu Val
260
<210>146
<21l>772
<212>PRT
<213>人
<400>146
Met Gly Asp Glu Asp Asp Asp Glu Ser Cys Ala Val Glu Leu Arg Ile
l 5 10 15
Thr Glu Ala Asn Leu Thr Gly His Glu Glu Lys Val Ser Val Glu Asn
20 25 30
Phe Glu Leu Leu Lys Val Leu Gly Thr Gly Ala Tyr Gly Lys Val Phe
35 40 45
Leu Val Arg Lys Ala Gly Gly His Asp Ala Gly Lys Leu Tyr Ala Met
50 55 60
Lys Val Leu Arg Lys Ala Ala Leu Val Gln Arg Ala Lys Thr Gln Glu
65 70 75 80
His Thr Arg Thr Glu Arg Ser Val Leu Glu Leu Val Arg Gln Ala Pro
85 90 95
Phe Leu Val Thr Leu His Tyr Ala Phe Gln Thr Asp Ala Lys Leu His
100 105 110
Leu Ile Leu Asp Tyr Val Ser Gly Gly Glu Met Phe Thr His Leu Tyr
115 120 125
Gln Arg Gln Tyr Phe Lys Glu Ala Glu Val Arg Val Tyr Gly Gly Glu
130 135 140
Ile Val Leu Ala Leu Glu His Leu His Lys Leu Gly Ile Ile Tyr Arg
145 150 155 160
Asp Leu Lys Leu Glu Asn Val Leu Leu Asp Ser Glu Gly His Ile Val
165 170 175
Leu Thr Asp Phe Gly Leu Ser Lys Glu Phe Leu Thr Glu Glu Lys Glu
180 185 190
Arg Thr Phe Ser Phe Cys Gly Thr Ile Glu Tyr Met Ala Pro Glu Ile
195 200 205
Ile Arg Ser Lys Thr Gly His Gly Lys Ala Val Asp Trp Trp Ser Leu
210 215 220
Gly Ile Leu Leu Phe Glu Leu Leu Thr Gly Ala Ser Pro Phe Thr Leu
225 230 235 240
Glu Gly Glu Arg Asn Thr Gln Ala Glu Val Ser Arg Arg Ile Leu Lys
245 250 255
Cys Ser Pro Pro Phe Pro Pro Arg Ile Gly Pro Val Ala Gln Asp Leu
260 265 270
Leu Gln Arg Leu Leu Cys Lys Asp Pro Lys Lys Arg Leu Gly Ala Gly
275 280 285
Pro Gln Gly Ala Gln Glu Val Arg Asn His Pro Phe Phe Gln Gly Leu
290 295 300
Asp Trp Val Ala Leu Ala Ala Arg Lys Ile Pro Ala Pro Phe Arg Pro
305 3l0 315 320
Gln Ile Arg Ser Glu Leu Asp Val Gly Asn Phe Ala Glu Glu Phe Thr
325 330 335
Arg Leu Glu Pro Val Tyr Ser Pro Pro Gly Ser Pro Pro Pro Gly Asp
340 345 350
Pro Arg Ile Phe Gln Gly Tyr Ser Phe Val Ala Pro Ser Ile Leu Phe
355 360 365
Asp His Asn Asn Ala Val Met Thr Asp Gly Leu Glu Ala Pro Gly Ala
370 375 380
Gly Asp Arg Pro Gly Arg Ala Ala Val Ala Arg Ser Ala Met Met Gln
385 390 395 400
Asp Ser Pro Phe Phe Gln Gln Tyr Glu Leu Asp Leu Arg Glu Pro Ala
405 410 415
Leu Gly Gln Gly Ser Phe Ser Val Cys Arg Arg Cys Arg Gln Arg Gln
420 425 430
Ser Gly Gln Glu Phe Ala Val Lys Ile Leu Ser Arg Arg Leu Glu Ala
435 440 445
Asn Thr Gln Arg Glu Val Ala Ala Leu Arg Leu Cys Gln Ser His Pro
450 455 460
Asn Val Val Asn Leu His Glu Val His His Asp Gln Leu His Thr Tyr
465 470 475 480
Leu Val Leu Glu Leu Leu Arg Gly Gly Glu Leu Leu Glu His Ile Arg
485 490 495
Lys Lys Arg His Phe Ser Glu Ser Glu Ala Ser Gln Ile Leu Arg Ser
500 505 510
Leu Val Ser Ala Val Ser Phe Met His Glu Glu Ala Gly Val Val His
515 520 525
Arg Asp Leu Lys Pro Glu Asn Ile Leu Tyr Ala Asp Asp Thr Pro Gly
530 535 540
Ala Pro Val Lys Ile Ile Asp Phe Gly Phe Ala Arg Leu Arg Pro Gln
545 550 555 560
Ser Pro Gly Val Pro Met Gln Thr Pro Cys Phe Thr Leu Gln Tyr Ala
565 570 575
Ala Pro Glu Leu Leu Ala Gln Gln Gly Tyr Asp Glu Ser Cys Asp Leu
580 585 590
Trp Ser Leu Gly Val Ile Leu Tyr Met Met Leu Ser Gly Gln Val Pro
595 600 605
Phe Gln Gly Ala Ser Gly Gln Gly Gly Gln Ser Gln Ala Ala Glu Ile
610 615 620
Met Cys Lys Ile Arg Glu Gly Arg Phe Ser Leu Asp Gly Glu Ala Trp
625 630 635 640
Gln Gly Val Ser Glu Glu Ala Lys Glu Leu Val Arg Gly Leu Leu Thr
645 650 655
Val Asp Pro Ala Lys Arg Leu Lys Leu Glu Gly Leu Arg Gly Ser Ser
660 665 670
Trp Leu Gln Asp Gly Ser Ala Arg Ser Ser Pro Pro Leu Arg Thr Pro
675 680 685
Asp Val Leu Glu Ser Ser Gly Pro Ala Val Arg Ser Gly Leu Asn Ala
690 695 700
Thr Phe Met Ala Phe Asn Arg Gly Lys Arg Glu Gly Phe Phe Leu Lys
705 710 715 720
Ser ValGlu Asn Ala Pro Leu Ala Lys Arg Arg Lys Gln Lys Leu Arg
725 730 735
Ser Ala Thr Ala Ser Arg Arg Gly Ser Pro Ala Pro Ala Asn Pro Gly
740 745 750
Arg Ala Pro Val Ala Ser Lys Gly Ala Pro Arg Arg Ala Asn Gly Pro
755 760 765
Leu Pro Pro Ser
770
<210>147
<211>1684
<212>PRT
<213>人
<400>147
Met Glu Asp Leu Val Gln Asp Gly Val Ala Ser Pro Ala Thr Pro Gly
1 5 10 15
Thr Gly Lys Ser Lys Leu Glu Thr Leu Pro Lys Glu Asp Leu Ile Lys
20 25 30
Phe Ala Lys Lys Gln Met Met Leu Ile Gln Lys Ala Lys Ser Arg Cys
35 40 45
Thr Glu Leu Glu Lys Glu Ile Glu Glu Leu Arg Ser Lys Pro Val Thr
50 55 60
Glu Gly Thr Gly Asp Ile Ile Lys Ala Leu Thr Glu Arg Leu Asp Ala
70 75 80
Leu Leu Leu Glu Lys Ala Glu Thr Glu Gln Gln Cys Leu Ser Leu Lys
85 90 95
Lys Glu Asn Ile Lys Met Lys Gln Glu Val Glu Asp Ser Val Thr Lys
100 105 110
Met Gly Asp Ala His Lys Glu Leu Glu Gln Ser His Ile Asn Tyr Val
115 120 125
Lys Glu Ile Glu Asn Leu Lys Asn Glu Leu Met Ala Val Arg Ser Lys
130 135 140
Tyr Ser Glu Asp Lys Ala Asn Leu Gln Lys Gln Leu Glu Glu Ala Met
145 150 155 160
Asn Thr Gln Leu Glu Leu Ser Glu Gln Leu Lys Phe Gln Asn Asn Ser
165 170 175
Glu Asp Asn Val Lys Lys Leu Gln Glu Glu Ile Glu Lys Ile Arg Pro
180 185 190
Gly Phe Glu Glu Gln Ile Leu Tyr Leu Gln Lys Gln Leu Asp Ala Thr
195 200 205
Thr Asp Glu Lys Lys Glu Thr Val Thr Gln Leu Gln Asn Ile Ile Glu
210 215 220
Ala Asn Ser Gln His Tyr Gln Lys Asn Ile Asn Ser Leu Gln Glu Glu
225 230 235 240
Leu Leu Gln Leu Lys Ala Ile His Gln Glu Glu Val Lys Glu Leu Met
245 250 255
Cys Gln Ile Glu Ala Ser Ala Lys Glu His Glu Ala Glu Ile Asn Lys
260 265 270
Leu Asn Glu Leu Lys Glu Asn Leu ValLys Gln Cys Glu Ala Ser Glu
275 280 285
Lys Asn Ile Gln Lys Lys Tyr Glu Cys Glu Leu Glu Asn Leu Arg Lys
290 295 300
Ala Thr Ser Asn Ala Asn Gln Asp Asn Gln Ile Cys Ser Ile Leu Leu
305 310 315 320
Gln Glu Asn Thr Phe Val Glu Gln Val Val Asn Glu Lys Val Lys His
325 330 335
Leu Glu Asp Thr Leu Lys Glu Leu Glu Ser Gln His Ser Ile Leu Lys
340 345 350
Asp Glu Val Thr Tyr Met Asn Asn Leu Lys Leu Lys Leu Glu Met Asp
355 360 365
Ala Gln His Ile Lys Asp Glu Phe Phe His Glu Arg Glu Asp Leu Glu
370 375 380
Phe Lys Ile Asn Glu Leu Leu Leu Ala Lys Glu Glu Gln Gly Cys Val
385 390 395 400
Ile Glu Lys Leu Lys Ser Glu Leu Ala Gly Leu Asn Lys Gln Phe Cys
405 410 415
Tyr Thr Val Glu Gln His Asn Arg Glu Val Gln Ser Leu Lys Glu Gln
420 425 430
His Gln Lys Glu Ile Ser Glu Leu Asn Glu Thr Phe Leu Ser Asp Ser
435 440 445
Glu Lys Glu Lys Leu Thr Leu Met Phe Glu Ile Gln Gly Leu Lys Glu
450 455 460
Gln Cys Glu Asn Leu Gln Gln Glu Lys Gln Glu Ala Ile Leu Asn Tyr
465 470 475 480
Glu Ser Leu Arg Glu Ile Met Glu Ile Leu Gln Thr Glu Leu Gly Glu
485 490 495
Ser Ala Gly Lys Ile Ser Gln Glu Phe Glu Ser Met Lys Gln Gln Gln
500 505 510
Ala Ser Asp Val His Glu Leu Gln Gln Lys Leu Arg Thr Ala Phe Thr
515 520 525
Glu Lys Asp Ala Leu Leu Glu Thr Val Asn Arg Leu Gln Gly Glu Asn
530 535 540
Glu Lys Leu Leu Ser Gln Gln Glu Leu Val Pro Glu Leu Glu Asn Thr
545 550 555 560
Ile Lys Asn Leu Gln Glu Lys Asn Gly Val Tyr Leu Leu Ser Leu Ser
565 570 575
Gln Arg Asp Thr Met Leu Lys Glu Leu Glu Gly Lys Ile Asn Ser Leu
580 585 590
Thr Glu Glu Lys Asp Asp Phe Ile Asn Lys Leu Lys Asn Ser His Glu
595 600 605
Glu Met Asp Asn Phe His Lys Lys Cys Glu Arg Glu Glu Arg Leu Ile
610 615 620
Leu Glu Leu Gly Lys Lys Val Glu Gln Thr Ile Gln Tyr Asn Ser Glu
625 630 635 640
Leu Glu Gln Lys Val Asn Glu Leu Thr Gly Gly Leu Glu Glu Thr Leu
645 650 655
Lys Glu Lys Asp Gln Asn Asp Gln Lys Leu Glu Lys Leu Met Val Gln
660 665 670
Met Lys Val Leu Ser Glu Asp Lys Glu Val Leu Ser Ala Glu Val Lys
675 680 685
Ser Leu Tyr Glu Glu Asn Asn Lys Leu Ser Ser Glu Lys Lys Gln Leu
690 695 700
Ser Arg Asp Leu Glu Val Phe Leu Ser Gln Lys Glu Asp Val Ile Leu
705 710 715 720
Lys Glu His Ile Thr Gln Leu Glu Lys Lys Leu Gln Leu Met Val Glu
725 730 735
Glu Gln Asp Asn Leu Asn Lys Leu Leu Glu Asn Glu Gln Val Gln Lys
740 745 750
Leu Phe Val Lys Thr Gln Leu Tyr Gly Phe Leu Lys Glu Met Gly Ser
755 760 765
Glu Val Ser Glu Asp Ser Glu Glu Lys Asp Val Val Asn Val Leu Gln
770 775 780
Ala Val Gly Glu Ser Leu Ala Lys Ile Asn Glu Glu Lys Cys Asn Leu
785 790 795 800
Ala Phe Gln Arg Asp Glu Lys Val Leu Glu Leu Glu Lys Glu Ile Lys
805 810 815
Cys Leu Gln Glu Glu Ser Val Val Gln Cys Glu Glu Leu Lys Ser Leu
820 825 830
Leu Arg Asp Tyr Glu Gln Glu Lys Val Leu Leu Arg Lys Glu Leu Glu
835 840 845
Glu Ile Gln Ser Glu Lys Glu Ala Leu Gln Ser Asp Leu Leu Glu Met
850 855 860
Lys Asn Ala Asn Glu Lys Thr Arg Leu Glu Asn Gln Asn Leu Leu Ile
865 870 875 880
Gln Val Glu Glu Val Ser Gln Thr Cys Ser Lys Ser Glu Ile His Asn
885 890 895
Glu Lys Glu Lys Cys Phe lle Lys Glu His Glu Asn Leu Lys Pro Leu
900 905 910
Leu Glu Gln Lys Glu Leu Arg Asp Arg Arg Ala Glu Leu Ile Leu Leu
915 920 925
Lys Asp Ser Leu Ala Lys Ser Pro Ser Val Lys Asn Asp Pro Leu Ser
930 935 940
Ser Val Lys Glu Leu Glu Glu Lys Ile Glu Asn Leu Glu Lys Glu Cys
945 950 955 960
Lys Glu Lys Glu Glu Lys Ile Asn Lys Ile Lys Leu Val Ala Val Lys
965 970 975
Ala Lys Lys Glu Leu Asp Ser Ser Arg Lys Glu Thr Gln Thr Val Lys
980 985 990
Glu Glu Leu Glu Ser Leu Arg Ser Glu Lys Asp Gln Leu Ser Ala Ser
995 1000 1005
Met Arg Asp Leu Ile Gln Gly Ala Glu Ser Tyr Lys Asn Leu Leu
1010 1015 1020
Leu Glu Tyr Glu Lys Gln Ser Glu Gln Leu Asp Val Glu Lys Glu
1025 1030 1035
Arg Ala Asn Asn Phe Glu His Arg Ile Glu Asp Leu Thr Arg Gln
1040 1045 1050
Leu Arg Asn Ser Thr Leu Gln Cys Glu Thr Ile Asn Ser Asp Asn
1055 1060 1065
Glu Asp Leu Leu Ala Arg Ile Glu Thr Leu Gln Ser Asn Ala Lys
1070 1075 1080
Leu Leu Glu Val Gln Ile Leu Glu Val Gln Arg Ala Lys Ala Met
1085 1090 1095
Val Asp Lys Glu Leu Glu Ala Glu Lys Leu Gln Lys Glu Gln Lys
1100 1105 1110
Ile Lys Glu His Ala Thr Thr Val Asn Glu Leu Glu Glu Leu Gln
1115 1120 1125
Val Gln Leu Gln Lys Glu Lys Lys Gln Leu Gln Lys Thr Met Gln
1130 1135 1140
Glu Leu Glu Leu Val Lys Lys Asp Ala Gln Gln Thr Thr Leu Met
1145 1150 1155
Asn Met Glu Ile Ala Asp Tyr Glu Arg Leu Met Lys Glu Leu Asn
1160 1165 1170
Gln Lys Leu Thr Asn Lys Asn Asn Lys Ile Glu Asp Leu Glu Gln
1175 1180 1185
Glu Ile Lys Ile Gln Lys Gln Lys Gln Glu Thr Leu Gln Glu Glu
1190 1195 1200
Ile Thr Ser Leu Gln Ser Ser Val Gln Gln Tyr Glu Glu Lys Asn
1205 1210 1215
Thr Lys Ile Lys Gln Leu Leu Val Lys Thr Lys Lys Glu Leu Ala
1220 1225 1230
Asp Ser Lys Gln Ala Glu Thr Asp His Leu Ile Leu Gln Ala Ser
1235 1240 1245
Leu Lys Gly Glu Leu Glu Ala Ser Gln Gln Gln Val Glu Val Tyr
1250 1255 1260
Lys Ile Gln Leu Ala Glu Ile Thr Ser Glu Lys His Lys Ile His
1265 1270 1275
Glu His Leu Lys Thr Ser Ala Glu Gln His Gln Arg Thr Leu Ser
1280 1285 1290
Ala Tyr Gln Gln Arg Val Thr Ala Leu Gln Glu Glu Cys Arg Ala
1295 1300 1305
Ala Lys Ala Glu Gln Ala Thr Val Thr Ser Glu Phe Glu Ser Tyr
1310 1315 1320
Lys Val Arg Val His Asn Val Leu Lys Gln Gln Lys Asn Lys Ser
1325 1330 1335
Met Ser Gln Ala Glu Thr Glu Gly Ala Lys Gln Glu Arg Glu His
1340 1345 1350
Leu Glu Met Leu Ile Asp Gln Leu Lys Ile Lys Leu Gln Asp Ser
1355 1360 1365
Gln Asn Asn Leu Gln Ile Asn Val Ser Glu Leu Gln Thr Leu Gln
1370 1375 1380
Ser Glu His Asp Thr Leu Leu Glu Arg His Asn Lys Met Leu Gln
1385 1390 1395
Glu Thr Val Ser Lys Glu Ala Glu Leu Arg Glu Lys Leu Cys Ser
1400 1405 1410
Ile Gln Ser Glu Asn Met Met Met Lys Ser Glu His Thr Gln Thr
1415 1420 1425
Val Ser Gln Leu Thr Ser Gln Asn Glu Val Leu Arg Asn Ser Phe
1430 1435 1440
Arg Asp Gln Val Arg His Leu Gln Glu Glu His Arg Lys Thr Val
1445 1450 1455
Glu Thr Leu Gln Gln Gln Leu Ser Lys Met Glu Ala Gln Leu Phe
1460 1465 1470
Gln Leu Lys Asn Glu Pro Thr Thr Arg Ser Pro Val Ser Ser Gln
1475 1480 1485
Gln Ser Leu Lys Asn Leu Arg Glu Arg Arg Asn Thr Asp Leu Pro
1490 1495 1500
Leu Leu Asp Met His Thr Val Thr Arg Glu Glu Gly Glu Gly Met
1505 1510 1515
Glu Thr Thr Asp Thr Glu Ser Val Ser Ser Ala Ser Thr Tyr Thr
1520 1525 1530
Gln Ser Leu Glu Gln Leu Leu Asn Ser Pro Glu Thr Lys Leu Glu
1535 1540 1545
Pro Pro Leu Trp His Ala Glu Phe Thr Lys Glu Glu Leu Val Gln
1550 1555 1560
Lys Leu Ser Ser Thr Thr Lys Ser Ala Asp His Leu Asn Gly Leu
1565 1570 1575
Leu Arg Glu Thr Glu Ala Thr Asn Ala Ile Leu Met Glu Gln Ile
1580 1585 1590
Lys Leu Leu Lys Ser Glu Ile Arg Arg Leu Glu Arg Asn Gln Glu
1595 1600 1605
Arg Glu Lys Ser Ala Ala Asn Leu Glu Tyr Leu Lys Asn Val Leu
1610 1615 1620
Leu Gln Phe Ile Phe Leu Lys Pro Gly Ser Glu Arg Glu Arg Leu
1625 1630 1635
Leu Pro Val Ile Asn Thr Met Leu Gln Leu Ser Pro Glu Glu Lys
1640 1645 1650
Gly Lys Leu Ala Ala Val Ala Gln Gly Glu Glu Glu Asn Ala Ser
1655 1660 1665
Arg Ser Ser Gly Trp Ala Ser Tyr Leu His Ser Trp Ser Gly Leu
1670 1675 1680
Arg
<210>148
<211>288
<212>PRT
<213>人
<400>148
Met Val Gly Val Gly Gly Gly Asp Val Glu Asp Val Thr Pro Arg Pro
1 5 10 15
Gly Gly Cys Gln Ile Ser Gly Arg Ala Ala Arg Gly Cys Asn Gly Ile
20 25 30
Pro Gly Ala Ala Ala Trp Glu Ala Ala Leu Pro Arg Arg Arg Pro Arg
35 40 45
Arg His Pro Ser Val Asn Pro Arg Ser Arg Ala Ala Gly Ser Pro Arg
50 55 60
Thr Arg Gly Arg Arg Thr Glu Glu Arg Pro Ser Gly Ser Arg Leu Gly
65 70 75 80
Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly Gly Arg
85 90 95
Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg Gly Arg
100 105 110
Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser Arg Pro
115 120 125
Gly Pro Ala Gly Thr Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala
130 135 140
Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys
145 150 155 160
Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile
165 170 175
His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His
180 185 190
Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys
195 200 205
Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu
210 215 220
Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu
225 230 235 240
Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp
245 250 255
Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr
260 265 270
Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser
275 280 285
<210>149
<211>582
<212>PRT
<213>人
<400>149
Met Ser Pro Ala Pro Arg Pro Pro Arg Cys Leu Leu Leu Pro Leu Leu
1 5 10 15
Thr Leu Gly Thr Ala Leu Ala Ser Leu Gly Ser Ala Gln Ser Ser Ser
20 25 30
Phe Ser Pro Glu Ala Trp Leu Gln Gln Tyr Gly Tyr Leu Pro Pro Gly
35 40 45
Asp Leu Arg Thr His Thr Gln Arg Ser Pro Gln Ser Leu Ser Ala Ala
50 55 60
Ile Ala Ala Met Gln Lys Phe Tyr Gly Leu Gln Val Thr Gly Lys Ala
65 70 75 80
Asp Ala Asp Thr Met Lys Ala Met Arg Arg Pro Arg Cys Gly Val Pro
85 90 95
Asp Lys Phe Gly Ala Glu Ile Lys Ala Asn Val Arg Arg Lys Arg Tyr
100 105 110
Ala Ile Gln Gly Leu Lys Trp Gln His Asn Glu Ile Thr Phe Cys Ile
115 120 125
Gln Asn Tyr Thr Pro Lys Val Gly Glu Tyr Ala Thr Tyr Glu Ala Ile
130 135 140
Arg Lys Ala Phe Arg Val Trp Glu Ser Ala Thr Pro Leu Arg Phe Arg
145 150 155 160
Glu Val Pro Tyr Ala Tyr Ile Arg Glu Gly His Glu Lys Gln Ala Asp
165 170 175
lle Met Ile Phe Phe Ala Glu Gly Phe His Gly Asp Ser Thr Pro Phe
180 185 190
Asp Gly Glu Gly Gly Phe Leu Ala His Ala Tyr Phe Pro Gly Pro Asn
195 200 205
Ile Gly Gly Asp Thr His Phe Asp Ser Ala Glu Pro Trp Thr Val Arg
210 215 220
Asn Glu Asp Leu Asn Gly Asn Asp Ile Phe Leu Val Ala Val His Glu
225 230 235 240
Leu Gly His Ala Leu Gly Leu Glu His Ser Ser Asp Pro Ser Ala Ile
245 250 255
Met Ala Pro Phe Tyr Gln Trp Met Asp Thr Glu Asn Phe Val Leu Pro
260 265 270
Asp Asp Asp Arg Arg Gly Ile Gln Gln Leu Tyr Gly Gly Glu Ser Gly
275 280 285
Phe Pro Thr Lys Met Pro Pro Gln Pro Arg Thr Thr Ser Arg Pro Ser
290 295 300
Val Pro Asp Lys Pro Lys Asn Pro Thr Tyr Gly Pro Asn Ile Cys Asp
305 310 315 320
Gly Asn Phe Asp Thr Val Ala Met Leu Arg Gly Glu Met Phe Val Phe
325 330 335
Lys Glu Arg Trp Phe Trp Arg Val Arg Asn Asn Gln Val Met Asp Gly
340 345 350
Tyr Pro Met Pro Ile Gly Gln Phe Trp Arg Gly Leu Pro Ala Ser Ile
355 360 365
Asn Thr Ala Tyr Glu Arg Lys Asp Gly Lys Phe Val Phe Phe Lys Gly
370 375 380
Asp Lys His Trp Val Phe Asp Glu Ala Ser Leu Glu Pro Gly Tyr Pro
385 390 395 400
Lys His Ile Lys Glu Leu Gly Arg Gly Leu Pro Thr Asp Lys Ile Asp
405 410 415
Ala Ala Leu Phe Trp Met Pro Asn Gly Lys Thr Tyr Phe Phe Arg Gly
420 425 430
Asn Lys Tyr Tyr Arg Phe Asn Glu Glu Leu Arg Ala Val Asp Ser Glu
435 440 445
Tyr Pro Lys Asn Ile Lys Val Trp Glu Gly Ile Pro Glu Ser Pro Arg
450 455 460
Gly Ser Phe Met Gly Ser Asp Glu Val Phe Thr Tyr Phe Tyr Lys Gly
465 470 475 480
Asn Lys Tyr Trp Lys Phe Asn Asn Gln Lys Leu Lys Val Glu Pro Gly
485 490 495
Tyr Pro Lys Ser Ala Leu Arg Asp Trp Met Gly Cys Pro Ser Gly Gly
500 505 510
Arg Pro Asp Glu Gly Thr Glu Glu Glu Thr Glu Val Ile Ile Ile Glu
515 520 525
Val Asp Glu Glu Gly Gly Gly Ala Val Ser Ala Ala Ala Val Val Leu
530 535 540
Pro Val Leu Leu Leu Leu Leu Val Leu Ala Val Gly Leu Ala Val Phe
545 550 555 560
Phe Phe Arg Arg His Gly Thr Pro Arg Arg Leu Leu Tyr Cys Gln Arg
565 570 575
Ser Leu Leu Asp Lys Val
580
<210>150
<211>1255
<212>PRT
<213>人
<400>150
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
1 5 10 15
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
20 25 30
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
35 40 45
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
50 55 60
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65 70 75 80
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
85 90 95
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
100 105 110
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
115 120 125
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
130 135 140
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145 150 155 160
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
165 170 175
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
180 185 190
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
195 200 205
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
210 215 220
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225 230 235 240
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
245 250 255
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
260 265 270
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
275 280 285
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
290 295 300
Ser Thr Asp ValGly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305 310 315 320
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
325 330 335
Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu
340 345 350
Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys
355 360 365
Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp
370 375 380
Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe
385 390 395 400
Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro
405 410 415
Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg
420 425 430
Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu
435 440 445
Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly
450 455 460
Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val
465 470 475 480
Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr
485 490 495
Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His
500 505 510
Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys
515 520 525
Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys
530 535 540
Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys
545 550 555 560
Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys
565 570 575
Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp
580 585 590
Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu
595 600 605
Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln
610 615 620
Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys
625 630 635 640
Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser
645 650 655
Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly
660 665 670
Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg
675 680 685
Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly
690 695 700
Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu
705 710 715 720
Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys
725 730 735
Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile
740 745 750
Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu
755 760 765
Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg
770 775 780
Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu
785 790 795 800
Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg
805 810 815
Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly
820 825 830
Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala
835 840 845
Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe
850 855 860
Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp
865 870 875 880
Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg
885 890 895
Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val
900 905 910
Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala
915 920 925
Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro
930 935 940
Pro Ile Cys Thr Ile Asp Val Tyr Met lle Met Val Lys Cys Trp Met
945 950 955 960
Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe
965 970 975
Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu
980 985 990
Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser Leu
995 1000 1005
Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu Tyr
1010 1015 1020
Leu Val Pro Gln Gln Gly Phe Phe Cys Pro Asp Pro Ala Pro Gly
1025 1030 1035
Ala Gly Gly Met Val His His Arg His Arg Ser Ser Ser Thr Arg
1040 1045 1050
Ser Gly Gly Gly Asp Leu Thr Leu Gly Leu Glu Pro Ser Glu Glu
1055 1060 1065
Glu Ala Pro Arg Ser Pro Leu Ala Pro Ser Glu Gly Ala Gly Ser
1070 1075 1080
Asp Val Phe Asp Gly Asp Leu Gly Met Gly Ala Ala Lys Gly Leu
1085 1090 1095
Gln Ser Leu Pro Thr His Asp Pro Ser Pro Leu Gln Arg Tyr Ser
1100 1105 1110
Glu Asp Pro Thr Val Pro Leu Pro Ser Glu Thr Asp Gly Tyr Val
1115 1120 1125
Ala Pro Leu Thr Cys Ser Pro Gln Pro Glu Tyr Val Asn Gln Pro
1130 1135 1140
Asp Val Arg Pro Gln Pro Pro Ser Pro Arg Glu Gly Pro Leu Pro
1145 1150 1155
Ala Ala Arg Pro Ala Gly Ala Thr Leu Glu Arg Pro Lys Thr Leu
1160 1165 1170
Ser Pro Gly Lys Asn Gly Val Val Lys Asp Val Phe Ala Phe Gly
1175 1180 1185
Gly Ala Val Glu Asn Pro Glu Tyr Leu Thr Pro Gln Gly Gly Ala
1190 1195 1200
Ala Pro Gln Pro His Pro Pro Pro Ala Phe Ser Pro Ala Phe Asp
1205 1210 1215
Asn Leu Tyr Tyr Trp Asp Gln Asp Pro Pro Glu Arg Gly Ala Pro
1220 1225 1230
Pro Ser Thr Phe Lys Gly Thr Pro Thr Ala Glu Asn Pro Glu Tyr
1235 1240 1245
Leu Gly Leu Asp Val Pro Val
1250 1255
<210>151
<211>552
<212>PRT
<213>人
<400>15l
Met Ala Glu Lys Gln Lys His Asp Gly Arg Val Lys Ile Gly His Tyr
1 5 10 15
Val Leu Gly Asp Thr Leu Gly Val Gly Thr Phe Gly Lys Val Lys Ile
20 25 30
Gly Glu His Gln Leu Thr Gly His Lys Val Ala Val Lys Ile Leu Asn
35 40 45
Arg Gln Lys Ile Arg Ser Leu Asp Val Val Gly Lys Ile Lys Arg Glu
50 55 60
Ile Gln Asn Leu Lys Leu Phe Arg His Pro His Ile Ile Lys Leu Tyr
65 70 75 80
Gln Val Ile Ser Thr Pro Thr Asp Phe Phe Met Val Met Glu Tyr Val
85 90 95
Ser Gly Gly Glu Leu Phe Asp Tyr Ile Cys Lys His Gly Arg Val Glu
100 105 110
Glu Met Glu Ala Arg Arg Leu Phe Gln Gln Ile Leu Ser Ala Val Asp
115 120 125
Tyr Cys His Arg His Met Val Val His Arg Asp Leu Lys Pro Glu Asn
130 135 140
Val Leu Leu Asp Ala His Met Asn Ala Lys Ile Ala Asp Phe Gly Leu
145 150 155 160
Ser Asn Met Met Ser Asp Gly Glu Phe Leu Arg Thr Ser Cys Gly Ser
165 170 175
Pro Asn Tyr Ala Ala Pro Glu Val Ile Ser Gly Arg Leu Tyr Ala Gly
180 185 190
Pro Glu Val Asp Ile Trp Ser Cys Gly Val Ile Leu Tyr Ala Leu Leu
195 200 205
Cys Gly Thr Leu Pro Phe Asp Asp Glu His Val Pro Thr Leu Phe Lys
210 215 220
Lys Ile Arg Gly Gly Val Phe Tyr Ile Pro Glu Tyr Leu Asn Arg Ser
225 230 235 240
Val Ala Thr Leu Leu Met His Met Leu Gln Val Asp Pro Leu Lys Arg
245 250 255
Ala Thr Ile Lys Asp Ile Arg Glu His Glu Trp Phe Lys Gln Asp Leu
260 265 270
Pro Ser Tyr Leu Phe Pro Glu Asp Pro Ser Tyr Asp Ala Asn Val Ile
275 280 285
Asp Asp Glu Ala Val Lys Glu Val Cys Glu Lys Phe Glu Cys Thr Glu
290 295 300
Ser Glu Val Met Asn Ser Leu Tyr Ser Gly Asp Pro Gln Asp Gln Leu
305 310 315 320
Ala Val Ala Tyr His Leu Ile Ile Asp Asn Arg Arg Ile Met Asn Gln
325 330 335
Ala Ser Glu Phe Tyr Leu Ala Ser Ser Pro Pro Ser Gly Ser Phe Met
340 345 350
Asp Asp Ser Ala Met His Ile Pro Pro Gly Leu Lys Pro His Pro Glu
355 360 365
Arg Met Pro Pro Leu Ile Ala Asp Ser Pro Lys Ala Arg Cys Pro Leu
370 375 380
Asp Ala Leu Asn Thr Thr Lys Pro Lys Ser Leu Ala Val Lys Lys Ala
385 390 395 400
Lys Trp His Leu Gly Ile Arg Ser Gln Ser Lys Pro Tyr Asp Ile Met
405 410 415
Ala Glu Val Tyr Arg Ala Met Lys Gln Leu Asp Phe Glu Trp Lys Val
420 425 430
Val Asn Ala Tyr His Leu Arg Val Arg Arg Lys Asn Pro Val Thr Gly
435 440 445
Asn Tyr Val Lys Met Ser Leu Gln Leu Tyr Leu Val Asp Asn Arg Ser
450 455 460
Tyr Leu Leu Asp Phe Lys Ser Ile Asp Asp Glu Val Val Glu Gln Arg
465 470 475 480
Ser Gly Ser Ser Thr Pro Gln Arg Ser Cys Ser Ala Ala Gly Leu His
485 490 495
Arg Pro Arg Ser Ser Phe Asp Ser Thr Thr Ala Glu Ser His Ser Leu
500 505 510
Ser Gly Ser Leu Thr Gly Ser Leu Thr Gly Ser Thr Leu Ser Ser Val
515 520 525
Ser Pro Arg Leu Gly Ser His Thr Met Asp Phe Phe Glu Met Cys Ala
530 535 540
Ser Leu Ile Thr Thr Leu Ala Arg
545 550
<210>152
<211>837
<212>PRT
<213>人
<400>152
Met Phe Leu Trp Leu Phe Leu Ile Leu Ser Ala Leu Ile Ser Ser Thr
1 5 10 15
Asn Ala Asp Ser Asp Ile Ser Val Glu Ile Cys Asn Val Cys Ser Cys
20 25 30
Val Ser Val Glu Asn Val Leu Tyr Val Asn Cys Glu Lys Val Ser Val
35 40 45
Tyr Arg Pro Asn Gln Leu Lys Pro Pro Trp Ser Asn Phe Tyr His Leu
50 55 60
Asn Phe Gln Asn Asn Phe Leu Asn Ile Leu Tyr Pro Asn Thr Phe Leu
65 70 75 80
Asn Phe Ser His Ala Val Ser Leu His Leu Gly Asn Asn Lys Leu Gln
85 90 95
Asn Ile Glu Gly Gly Ala Phe Leu Gly Leu Ser Ala Leu Lys Gln Leu
100 105 110
His Leu Asn Asn Asn Glu Leu Lys Ile Leu Arg Ala Asp Thr Phe Leu
115 120 125
Gly Ile Glu Asn Leu Glu Tyr Leu Gln Ala Asp Tyr Asn Leu Ile Lys
130 135 140
Tyr Ile Glu Arg Gly Ala Phe Asn Lys Leu His Lys Leu Lys Val Leu
145 150 155 160
Ile Leu Asn Asp Asn Leu Ile Ser Phe Leu Pro Asp Asn Ile Phe Arg
165 170 175
Phe Ala Ser Leu Thr His Leu Asp Ile Arg Gly Asn Arg Ile Gln Lys
180 185 190
Leu Pro Tyr Ile Gly Val Leu Glu His Ile Gly Arg Val Val Glu Leu
195 200 205
Gln Leu Glu Asp Asn Pro Trp Asn Cys Ser Cys Asp Leu Leu Pro Leu
210 215 220
Lys Ala Trp Leu Glu Asn Met Pro Tyr Asn Ile Tyr Ile Gly Glu Ala
225 230 235 240
Ile Cys Glu Thr Pro Ser Asp Leu Tyr Gly Arg Leu Leu Lys Glu Thr
245 250 255
Asn Lys Gln Glu Leu Cys Pro Met Gly Thr Gly Ser Asp Phe Asp Val
260 265 270
Arg Ile Leu Pro Pro Ser Gln Leu Glu Asn Gly Tyr Thr Thr Pro Asn
275 280 285
Gly His Thr Thr Gln Thr Ser Leu His Arg Leu Val Thr Lys Pro Pro
290 295 300
Lys Thr Thr Asn Pro Ser Lys Ile Ser Gly Ile Val Ala Gly Lys Ala
305 310 315 320
Leu Ser Asn Arg Asn Leu Ser Gln Ile Val Ser Tyr Gln Thr Arg Val
325 330 335
Pro Pro Leu Thr Pro Cys Pro Ala Pro Cys Phe Cys Lys Thr His Pro
340 345 350
Ser Asp Leu Gly Leu Ser Val Asn Cys Gln Glu Lys Asn Ile Gln Ser
355 360 365
Met Ser Glu Leu Ile Pro Lys Pro Leu Asn Ala Lys Lys Leu His Val
370 375 380
Asn Gly Asn Ser Ile Lys Asp Val Asp Val Ser Asp Phe Thr Asp Phe
385 390 395 400
Glu Gly Leu Asp Leu Leu His Leu Gly Ser Asn Gln Ile Thr Val Ile
405 410 415
Lys Gly Asp Val Phe His Asn Leu Thr Asn Leu Arg Arg Leu Tyr Leu
420 425 430
Asn Gly Asn Gln Ile Glu Arg Leu Tyr Pro Glu Ile Phe Ser Gly Leu
435 440 445
His Asn Leu Gln Tyr Leu Tyr Leu Glu Tyr Asn Leu Ile Lys Glu Ile
450 455 460
Ser Ala Gly Thr Phe Asp Ser Met Pro Asn Leu Gln Leu Leu Tyr Leu
465 470 475 480
Asn Asn Asn Leu Leu Lys Ser Leu Pro Val Tyr Ile Phe Ser Gly Ala
485 490 495
Pro Leu Ala Arg Leu Asn Leu Arg Asn Asn Lys Phe Met Tyr Leu Pro
500 505 510
Val Ser Gly Val Leu Asp Gln Leu Gln Ser Leu Thr Gln Ile Asp Leu
515 520 525
Glu Gly Asn Pro Trp Asp Cys Thr Cys Asp Leu Val Ala Leu Lys Leu
530 535 540
Trp Val Glu Lys Leu Ser Asp Gly Ile Val Val Lys Glu Leu Lys Cys
545 550 555 560
Glu Thr Pro Val Gln Phe Ala Asn Ile Glu Leu Lys Ser Leu Lys Asn
565 570 575
Glu Ile Leu Cys Pro Lys Leu Leu Asn Lys Pro Ser Ala Pro Phe Thr
580 585 590
Ser Pro Ala Pro Ala Ile Thr Phe Thr Thr Pro Leu Gly Pro Ile Arg
595 600 605
Ser Pro Pro Gly Gly Pro Val Pro Leu Ser Ile Leu Ile Leu Ser Ile
610 615 620
Leu Val Val Leu Ile Leu Thr Val Phe Val Ala Phe Cys Leu Leu Val
625 630 635 640
Phe Val Leu Arg Arg Asn Lys Lys Pro Thr Val Lys His Glu Gly Leu
645 650 655
Gly Asn Pro Asp Cys Gly Ser Met Gln Leu Gln Leu Arg Lys His Asp
660 665 670
His Lys Thr Asn Lys Lys Asp Gly Leu Ser Thr Glu Ala Phe Ile Pro
675 680 685
Gln Thr Ile Glu Gln Met Ser Lys Ser His Thr Cys Gly Leu Lys Glu
690 695 700
Ser Glu Thr Gly Phe Met Phe Ser Asp Pro Pro Gly Gln Lys Val Val
705 710 715 720
Met Arg Asn Val Ala Asp Lys Glu Lys Asp Leu Leu His Val Asp Thr
725 730 735
Arg Lys Arg Leu Ser Thr Ile Asp Glu Leu Asp Glu Leu Phe Pro Ser
740 745 750
Arg Asp Ser Asn Val Phe Ile Gln Asn Phe Leu Glu Ser Lys Lys Glu
755 760 765
Tyr Asn Ser Ile Gly Val Ser Gly Phe Glu Ile Arg Tyr Pro Glu Lys
770 775 780
Gln Pro Asp Lys Lys Ser Lys Lys Ser Leu Ile Gly Gly Asn His Ser
785 790 795 800
Lys Ile Val Val Glu Gln Arg Lys Ser Glu Tyr Phe Glu Leu Lys Ala
805 810 815
Lys Leu Gln Ser Ser Pro Asp Tyr Leu Gln Val Leu Glu Glu Gln Thr
820 825 830
Ala Leu Asn Lys Ile
835
<210>153
<211>379
<212>PRT
<213>人
<400>153
Met Pro Arg Ser Ser Arg Ser Pro Gly Asp Pro Gly Ala Leu Leu Glu
1 5 10 15
Asp Val Ala His Asn Pro Arg Pro Arg Arg Ile Ala Gln Arg Gly Arg
20 25 30
Asn Thr Ser Arg Met Ala Glu Asp Thr Ser Pro Asn Met Asn Asp Asn
35 40 45
Ile Leu Leu Pro Val Arg Asn Asn Asp Gln Ala Leu Gly Leu Thr Gln
50 55 60
Cys Met Leu Gly Cys Val Ser Trp Phe Thr Cys Phe Ala Cys Ser Leu
65 70 75 80
Arg Thr Gln Ala Gln Gln Val Leu Phe Asn Thr Cys Arg Cys Lys Leu
85 90 95
Leu Cys Gln Lys Leu Met Glu Lys Thr Gly Ile Leu Leu Leu Cys Ala
100 105 110
Phe Gly Phe Trp Met Phe Ser Ile His Leu Pro Ser Lys Met Lys Val
115 120 125
Trp Gln Asp Asp Ser Ile Asn Gly Pro Leu Gln Ser Leu Arg Leu Tyr
130 135 140
Gln Glu Lys Val Arg His His Ser Gly Glu Ile Gln Asp Leu Arg Gly
145 150 155 160
Ser Met Asn Gln Leu Ile Ala Lys Leu Gln Glu Met Glu Ala Met Ser
165 170 175
Asp Glu Gln Lys Met Ala Gln Lys Ile Met Lys Met Ile His Gly Asp
180 185 190
Tyr Ile Glu Lys Pro Asp Phe Ala Leu Lys Ser Ile Gly Ala Ser Ile
195 200 205
Asp Phe Glu His Thr Ser Val Thr Tyr Asn His Glu Lys Ala His Ser
210 215 220
Tyr Trp Asn Trp Ile Gln Leu Trp Asn Tyr Ala Gln Pro Pro Asp Val
225 230 235 240
Ile Leu Glu Pro Asn Val Thr Pro Gly Asn Cys Trp Ala Phe Glu Gly
245 250 255
Asp Arg Gly Gln Val Thr Ile Gln Leu Ala Gln Lys Val Tyr Leu Ser
260 265 270
Asn Leu Thr Leu Gln His Ile Pro Lys Thr Ile Ser Leu Ser Gly Ser
275 280 285
Leu Asp Thr Ala Pro Lys Asp Phe Val Ile Tyr Gly Met Glu Gly Ser
290 295 300
Pro Lys Glu Glu Val Phe Leu Gly Ala Phe Gln Phe Gln Pro Glu Asn
305 310 315 320
Ile Ile Gln Met Phe Pro Leu Gln Asn Gln Pro Ala Arg Ala Phe Ser
325 330 335
Ala Val Lys Val Lys Ile Ser Ser Asn Trp Gly Asn Pro Gly Phe Thr
340 345 350
Cys Leu Tyr Arg Val Arg Val His Gly Ser Val Ala Pro Pro Arg Glu
355 360 365
Gln Pro His Gln Asn Pro Tyr Pro Lys Arg Asp
370 375
<210>154
<211>601
<212>PRT
<213>人
<400>154
Met His Pro Leu Gln Cys Val Leu Gln Val Gln Arg Ser Leu Gly Trp
1 5 10 15
Gly Pro Leu Ala Ser Val Ser Trp Leu Ser Leu Arg Met Cys Arg Ala
20 25 30
His Ser Ser Leu Ser Ser Thr Met Cys Pro Ser Pro Glu Arg Gln Glu
35 40 45
Asp Gly Ala Arg Lys Asp Phe Ser Ser Arg Leu Ala Ala Gly Pro Thr
50 55 60
Phe Gln His Phe Leu Lys Ser Ala Ser Ala Pro Gln Glu Lys Leu Ser
65 70 75 80
Ser Glu Val Glu Asp Pro Pro Pro Tyr Leu Met Met Asp Glu Leu Leu
85 90 95
Gly Arg Gln Arg Lys Val Tyr Leu Glu Thr Tyr Gly Cys Gln Met Asn
100 105 110
Val Asn Asp Thr Glu Ile Ala Trp Ser Ile Leu Gln Lys Ser Gly Tyr
115 120 125
Leu Arg Thr Ser Asn Leu Gln Glu Ala Asp Val Ile Leu Leu Val Thr
130 135 140
Cys Ser Ile Arg Glu Lys Ala Glu Gln Thr Ile Trp Asn Arg Leu His
145 150 155 160
Gln Leu Lys Ala Leu Lys Thr Arg Arg Pro Arg Ser Arg Val Pro Leu
165 170 175
Arg Ile Gly Ile Leu Gly Cys Met Ala Glu Arg Leu Lys Glu Glu Ile
180 185 190
Leu Asn Arg Glu Lys Met Val Asp Ile Leu Ala Gly Pro Asp Ala Tyr
195 200 205
Arg Asp Leu Pro Arg Leu Leu Ala Val Ala Glu Ser Gly Gln Gln Ala
210 215 220
Ala Asn Val Leu Leu Ser Leu Asp Glu Thr Tyr Ala Asp Val Met Pro
225 230 235 240
Val Gln Thr Ser Ala Ser Ala Thr Ser Ala Phe Val Ser Ile Met Arg
245 250 255
Gly Cys Asp Asn Met Cys Ser Tyr Cys Ile Val Pro Phe Thr Arg Gly
260 265 270
Arg Glu Arg Ser Arg Pro Ile Ala Ser Ile Leu Glu Glu Val Lys Lys
275 280 285
Leu Ser Glu Gln Val Phe Leu Pro Pro Arg Pro Pro Lys Val Leu Gly
290 295 300
Leu Gln Gly Leu Lys Glu Val Thr Leu Leu Gly Gln Asn Val Asn Ser
305 310 315 320
Phe Arg Asp Asn Ser Glu Val Gln Phe Asn Ser Ala Val Pro Thr Asn
325 330 335
Leu Ser Arg Gly Phe Thr Thr Asn Tyr Lys Thr Lys Gln Gly Gly Leu
340 345 350
Arg Phe Ala His Leu Leu Asp Gln Val Ser Arg Val Asp Pro Glu Met
355 360 365
Arg Ile Arg Phe Thr Ser Pro His Pro Lys Asp Phe Pro Asp Glu Val
370 375 380
Leu Gln Leu Ile His Glu Arg Asp Asn Ile Cys Lys Gln Ile His Leu
385 390 395 400
Pro Ala Gln Ser Gly Ser Ser Arg Val Leu Glu Ala Met Arg Arg Gly
405 410 415
Tyr Ser Arg Glu Ala Tyr Val Glu Leu Val His His Ile Arg Glu Ser
420 425 430
Ile Pro Gly Val Ser Leu Ser Ser Asp Phe Ile Ala Gly Phe Cys Gly
435 440 445
Glu Thr Glu Glu Asp His Val Gln Thr Val Ser Leu Leu Arg Glu Val
450 455 460
Gln Tyr Asn Met Gly Phe Leu Phe Ala Tyr Ser Met Arg Gln Lys Thr
465 470 475 480
Arg Ala Tyr His Arg Leu Lys Asp Asp Val Pro Glu Glu Val Lys Leu
485 490 495
Arg Arg Leu Glu Glu Leu Ile Thr Ile Phe Arg Glu Glu Ala Thr Lys
500 505 510
Ala Asn Gln Thr Ser Val Gly Cys Thr Gln Leu Val Leu Val Glu Gly
515 520 525
Leu Ser Lys Arg Ser Ala Thr Asp Leu Cys Gly Arg Asn Asp Gly Asn
530 535 540
Leu Lys Val Ile Phe Pro Asp Ala Glu Met Glu Asp Val Asn Asn Pro
545 550 555 560
Gly Leu Arg Val Arg Ala Gln Pro Gly Asp Tyr Val Leu Val Lys Ile
565 570 575
Thr Ser Ala Ser Ser Gln Thr Leu Arg Gly His Val Leu Cys Arg Thr
580 585 590
Thr Leu Arg Asp Ser Ser Ala Tyr Cys
595 600
<210>155
<211>356
<212>PRT
<213>人
<400> 155
Met Ser Pro Cys Gly Arg Ala Arg Arg Gln Thr Ser Arg Gly Ala Met
1 5 10 15
Ala Val Leu Ala Trp Lys Phe Pro Arg Thr Arg Leu Pro Met Gly Ala
20 25 30
Ser Ala Leu Cys Val Val Val Leu Cys Trp Leu Tyr Ile Phe Pro Val
35 40 45
Tyr Arg Leu Pro Asn Glu Lys Glu Ile Val Gln Gly Val Leu Gln Gln
50 55 60
Gly Thr Ala Trp Arg Arg Asn Gln Thr Ala Ala Arg Ala Phe Arg Lys
65 70 75 80
Gln Met Glu Asp Cys Cys Asp Pro Ala His Leu Phe Ala Met Thr Lys
85 90 95
Met Asn Ser Pro Met Gly Lys Ser Met Trp Tyr Asp Gly Glu Phe Leu
100 105 110
Tyr Ser Phe Thr Ile Asp Asn Ser Thr Tyr Ser Leu Phe Pro Gln Ala
115 120 125
Thr Pro Phe Gln Leu Pro Leu Lys Lys Cys Ala Val Val Gly Asn Gly
130 135 140
Gly Ile Leu Lys Lys Ser Gly Cys Gly Arg Gln Ile Asp Glu Ala Asn
145 150 155 160
Phe Val Met Arg Cys Asn Leu Pro Pro Leu Ser Ser Glu Tyr Thr Lys
165 170 175
Asp Val Gly Ser Lys Ser Gln Leu Val Thr Ala Asn Pro Ser Ile Ile
180 185 190
Arg Gln Arg Phe Gln Asn Leu Leu Trp Ser Arg Lys Thr Phe Val Asp
195 200 205
Asn Met Lys Ile Tyr Asn His Ser Tyr Ile Tyr Met Pro Ala Phe Ser
210 215 220
Met Lys Thr Gly Thr Glu Pro Ser Leu Arg Val Tyr Tyr Thr Leu Ser
225 230 235 240
Asp Val Gly Ala Asn Gln Thr Val Leu Phe Ala Asn Pro Asn Phe Leu
245 250 255
Arg Ser Ile Gly Lys Phe Trp Lys Ser Arg Gly Ile His Ala Lys Arg
260 265 270
Leu Ser Thr Gly Leu Phe Leu Val Ser Ala Ala Leu Gly Leu Cys Glu
275 280 285
Glu Val Ala Ile Tyr Gly Phe Trp Pro Phe Ser Val Asn Met His Glu
290 295 300
Gln Pro Ile Ser His His Tyr Tyr Asp Asn Val Leu Pro Phe Ser Gly
305 310 315 320
Phe His Ala Met Pro Glu Glu Phe Leu Gln Leu Trp Tyr Leu His Lys
325 330 335
Ile Gly Ala Leu Arg Met Gln Leu Asp Pro Cys Glu Asp Thr Ser Leu
340 345 350
Gln Pro Thr Ser
355
<210>156
<211>404
<212>PRT
<213>人
<400>156
Met Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly
1 5 10 15
Tyr Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe
20 25 30
Ala Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala Pro Ala Ser
35 40 45
Val Leu Pro Ala Ala Thr Pro Arg Gln Ser Leu Gly His Pro Pro Pro
50 55 60
Glu Pro Gly Pro Asp Arg Val Ala Asp Ala Lys Gly Asp Ser Glu Ser
65 70 75 80
Glu Glu Asp Glu Asp Leu Glu Val Pro Val Pro Ser Arg Phe Asn Arg
85 90 95
Arg Val Ser Val Cys Ala Glu Thr Tyr Asn Pro Asp Glu Glu Glu Glu
100 105 110
Asp Thr Asp Pro Arg Val lle His Pro Lys Thr Asp Glu Gln Arg Cys
115 120 125
Arg Leu Gln Glu Ala Cys Lys Asp Ile Leu Leu Phe Lys Asn Leu Asp
130 135 140
Gln Glu Gln Leu Ser Gln Val Leu Asp Ala Met Phe Glu Arg Ile Val
145 150 155 160
Lys Ala Asp Glu His Val Ile Asp Gln Gly Asp Asp Gly Asp Asn Phe
165 170 175
Tyr Val Ile Glu Arg Gly Thr Tyr Asp Ile Leu Val Thr Lys Asp Asn
180 185 190
Gln Thr Arg Ser Val Gly Gln Tyr Asp Asn Arg Gly Ser Phe Gly Glu
195 200 205
Leu Ala Leu Met Tyr Asn Thr Pro Arg Ala Ala Thr Ile Val Ala Thr
210 215 220
Ser Glu Gly Ser Leu Trp Gly Leu Asp Arg Val Thr Phe Arg Arg Ile
225 230 235 240
Ile Val Lys Asn Asn Ala Lys Lys Arg Lys Met Phe Glu Ser Phe Ile
245 250 255
Glu Ser Val Pro Leu Leu Lys Ser Leu Glu Val Ser Glu Arg Met Lys
260 265 270
Ile Val Asp Val Ile Gly Glu Lys Ile Tyr Lys Asp Gly Glu Arg Ile
275 280 285
lle Thr Gln Gly Glu Lys Ala Asp Ser Phe Tyr Ile Ile Glu Ser Gly
290 295 300
Glu Val Ser Ile Leu Ile Arg Ser Arg Thr Lys Ser Asn Lys Asp Gly
305 310 315 320
Gly Asn Gln Glu Val Glu Ile Ala Arg Cys His Lys Gly Gln Tyr Phe
325 330 335
Gly Glu Leu Ala Leu Val Thr Asn Lys Pro Arg Ala Ala Ser Ala Tyr
340 345 350
Ala Val Gly Asp Val Lys Cys Leu Val Met Asp Val Gln Ala Phe Glu
355 360 365
Arg Leu Leu Gly Pro Cys Met Asp Ile Met Lys Arg Asn Ile Ser His
370 375 380
Tyr Glu Glu Gln Leu Val Lys Met Phe Gly Ser Ser Val Asp Leu Gly
385 390 395 400
Asn Leu Gly Gln
<210>157
<211>505
<212>PRT
<213>人
<400>157
Met Ser Gly Ala Ser Ser Ser Glu Gln Asn Asn Asn Ser Tyr Glu Thr
1 5 10 15
Lys Thr Pro Asn Leu Arg Met Ser Glu Lys Lys Cys Ser Trp Ala Ser
20 25 30
Tyr Met Thr Asn Ser Pro Thr Leu Ile Val Met Ile Gly Leu Pro Ala
35 40 45
Arg Gly Lys Thr Tyr Val Ser Lys Lys Leu Thr Arg Tyr Leu Asn Trp
50 55 60
Ile Gly Val Pro Thr Lys Val Phe Asn Leu Gly Val Tyr Arg Arg Glu
65 70 75 80
Ala Val Lys Ser Tyr Lys Ser Tyr Asp Phe Phe Arg His Asp Asn Glu
85 90 95
Glu Ala Met Lys Ile Arg Lys Gln Cys Ala Leu Val Ala Leu Glu Asp
100 105 110
Val Lys Ala Tyr Leu Thr Glu Glu Asn Gly Gln Ile Ala Val Phe Asp
115 120 125
Ala Thr Asn Thr Thr Arg Glu Arg Arg Asp Met Ile Leu Asn Phe Ala
130 135v 140
Glu Gln Asn Ser Phe Lys Val Phe Phe Val Glu Ser Val Cys Asp Asp
145 150 155 160
Pro Asp Val Ile Ala Ala Asn Ile Leu Glu Val Lys Val Ser Ser Pro
165 170 175
Asp Tyr Pro Glu Arg Asn Arg Glu Asn Val Met Glu Asp Phe Leu Lys
180 185 190
Arg Ile Glu Cys Tyr Lys Val Thr Tyr Arg Pro Leu Asp Pro Asp Asn
195 200 205
Tyr Asp Lys Asp Leu Ser Phe Ile Lys Val Ile Asn Val Gly Gln Arg
210 215 220
Phe Leu Val Asn Arg Val Gln Asp Tyr Ile Gln Ser Lys Ile Val Tyr
225 230 235 240
Tyr Leu Met Asn Ile His Val Gln Pro Arg Thr Ile Tyr Leu Cys Arg
245 250 255
His Gly Glu Ser Glu Phe Asn Leu Leu Gly Lys Ile Gly Gly Asp Ser
260 265 270
Gly Leu Ser Val Arg Gly Lys Gln Phe Ala Gln Ala Leu Arg Lys Phe
275 280 285
Leu Glu Glu Gln Glu Ile Thr Asp Leu Lys Val Trp Thr Ser Gln Leu
290 295 300
Lys Arg Thr Ile Gln Thr Ala Glu Ser Leu Gly Val Pro Tyr Glu Gln
305 310 315 320
Trp Lys Ile Leu Asn Glu Ile Asp Ala Gly Val Cys Glu Glu Met Thr
325 330 335
Tyr Ala Glu Ile Glu Lys Arg Tyr Pro Glu Glu Phe Ala Leu Arg Asp
340 345 350
Gln Glu Lys Tyr Leu Tyr Arg Tyr Pro Gly Gly Glu Ser Tyr Gln Asp
355 360 365
Leu Val Gln Arg Leu Glu Pro Val Ile Met Glu Leu Glu Arg Gln Gly
370 375 380
Asn Val Leu Val Ile Ser His Gln Ala Val Met Arg Cys Leu Leu Ala
385 390 395 400
Tyr Phe Leu Asp Lys Gly Ala Asp Glu Leu Pro Tyr Leu Arg Cys Pro
405 410 415
Leu His Thr Ile Phe Lys Leu Thr Pro Val Ala Tyr Gly Cys Lys Val
42 425 430
Glu Thr Ile Lys Leu Asn Val Glu Ala Val Asn Thr His Arg Asp Lys
435 440 445
Pro Thr Asn Asn Phe Pro Lys Asn Gln Thr Pro Val Arg Met Arg Arg
450 455 460
Asn Ser Phe Thr Pro Leu Ser Ser Ser Asn Thr Ile Arg Arg Pro Arg
465 470 475 480
Asn Tyr Ser Val Gly Ser Arg Pro Leu Lys Pro Leu Ser Pro Leu Arg
485 490 495
Ala Gln Asp Met Gln Glu Gly Ala Asp
500 505
<210>158
<211>543
<212>PRT
<213>人
<400> 158
Met Met Pro Thr Pro Val Ile Leu Leu Lys Glu Gly Thr Asp Ser Ser
1 5 10 15
Gln Gly Ile Pro Gln Leu Val Ser Asn Ile Ser Ala Cys Gln Val Ile
20 25 30
Ala Glu Ala Val Arg Thr Thr Leu Gly Pro Arg Gly Met Asp Lys Leu
35 40 45
Ile Val Asp Gly Arg Gly Lys Ala Thr Ile Ser Asn Asp Gly Ala Thr
50 55 60
Ile Leu Lys Leu Leu Asp Val Val His Pro Ala Ala Lys Thr Leu Val
65 70 75 80
Asp Ile Ala Lys Ser Gln Asp Ala Glu Val Gly Asp Gly Thr Thr Ser
85 90 95
Val Thr Leu Leu Ala Ala Glu Phe Leu Lys Gln Val Lys Pro Tyr Val
100 105 110
Glu Glu Gly Leu His Pro Gln Ile Ile Ile Arg Ala Phe Arg Thr Ala
115 120 125
Thr Gln Leu Ala Val Asn Lys Ile Lys Glu Ile Ala Val Thr Val Lys
130 135 140
Lys Ala Asp Lys Val Glu Gln Arg Lys Leu Leu Glu Lys Cys Ala Met
145 150 155 160
Thr Ala Leu Ser Ser Lys Leu Ile Ser Gln Gln Lys Ala Phe Phe Ala
165 170 175
Lys Met Val Val Asp Ala Val Met Met Leu Asp Asp Leu Leu Gln Leu
180 185 190
Lys Met Ile Gly Ile Lys Lys Val Gln Gly Gly Ala Leu Glu Asp Ser
195 200 205
Gln Leu Val Ala Gly Val Ala Phe Lys Lys Thr Phe Ser Tyr Ala Gly
210 215 220
300
Phe Glu Met Gln Pro Lys Lys Tyr His Asn Pro Lys Ile Ala Leu Leu
225 230 235 240
Asn Val Glu Leu Glu Leu Lys Ala Glu Lys Asp Asn Ala Glu Ile Arg
245 250 255
Val His Thr Val Glu Asp Tyr Gln Ala Ile Val Asp Ala Glu Trp Asn
260 265 270
Ile Leu Tyr Asp Lys Leu Glu Lys Ile His His Ser Gly Ala Lys Val
275 280 285
Val Leu Ser Lys Leu Pro Ile Gly Asp Val Ala Thr Gln Tyr Phe Ala
290 295 300
Asp Arg Asp Met Phe Cys Ala Gly Arg Val Pro Glu Glu Asp Leu Lys
305 310 315 320
Arg Thr Met Met Ala Cys Gly Gly Ser Ile Gln Thr Ser Val Asn Ala
325 330 335
Leu Ser Ala Asp Val Leu Gly Arg Cys Gln Val Phe Glu Glu Thr Gln
340 345 350
Ile Gly Gly Glu Arg Tyr Asn Phe Phe Thr Gly Cys Pro Lys Ala Lys
355 360 365
Thr Cys Thr Phe Ile Leu Arg Gly Gly Ala Glu Gln Phe Met Glu Glu
370 375 380
Thr Glu Arg Ser Leu His Asp Ala Ile Met Ile Val Arg Arg Ala Ile
385 390 395 400
Lys Asn Asp Ser Val Val Ala Gly Gly Gly Ala Ile Glu Met Glu Leu
405 410 415
Ser Lys Tyr Leu Arg Asp Tyr Ser Arg Thr Ile Pro Gly Lys Gln Gln
420 425 430
Leu Leu Ile Gly Ala Tyr Ala Lys Ala Leu Glu Ile Ile Pro Arg Gln
435 440 445
Leu Cys Asp Asn Ala Gly Phe Asp Ala Thr Asn Ile Leu Asn Lys Leu
450 455 460
Arg Ala Arg His Ala Gln Gly Gly Thr Trp Tyr Gly Val Asp Ile Asn
465 470 475 480
Asn Glu Asp Ile Ala Asp Asn Phe Glu Ala Phe Val Trp Glu Pro Ala
485 490 495
Met Val Arg Ile Asn Ala Leu Thr Ala Ala Ser Glu Ala Ala Cys Leu
500 505 510
Ile Val Ser Val Asp Glu Thr Ile Lys Asn Pro Arg Ser Thr Val Asp
515 520 525
Ala Pro Thr Ala Ala Gly Arg Gly Arg Gly Arg Gly Arg Pro His
530 535 540
<210>159
<211>359
<212>PRT
<21 3>人
<400>159
Met Thr Leu Glu Ser Met Met Ala Cys Cys Leu Ser Asp Glu Val Lys
1 5 10 15
Glu Ser Lys Arg Ile Asn Ala Glu Ile Glu Lys Gln Leu Arg Arg Asp
20 25 30
Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly
35 40 45
Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly
50 55 60
Ala Gly Tyr Ser Glu Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr
65 70 75 80
Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Glu Thr
85 90 95
Leu Lys Ile Leu Tyr Lys Tyr Glu Gln Asn Lys Ala Asn Ala Leu Leu
100 105 110
Ile Arg Glu Val Asp Val Glu Lys Val Thr Thr Phe Glu His Gln Tyr
115 120 125
Val Ser Ala Ile Lys Thr Leu Trp Glu Asp Pro Gly Ile Gln Glu Cys
130 135 140
Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Ala Lys Tyr Tyr
145 150 155 160
Leu Thr Asp Val Asp Arg Ile Ala Thr Leu Gly Tyr Leu Pro Thr Gln
165 170 175
Gln Asp Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr
180 185 190
Pro Phe Asp Leu Glu Asn Ile Ile Phe Arg Met Val Asp Val Gly Gly
195 200 205
Gln Arg Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr
210 215 220
Ser Ile Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val
225 230 235 240
Glu Ser Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg
245 250 255
Thr Ile Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe
260 265 270
Leu Asn Lys Lys Asp Leu Leu Glu Asp Lys Ile Leu Tyr Ser His Leu
275 280 285
Val Asp Tyr Phe Pro Glu Phe Asp Gly Pro Gln Arg Asp Ala Gln Ala
290 295 300
Ala Arg Glu Phe Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser
305 310 315 320
Asp Lys Ile Ile Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn
325 330 335
Ile Arg Phe Val Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn
340 345 350
Leu Lys Glu Tyr Asn Leu Val
355
<210>160
<211>704
<212>PRT
<213>人
<400> 60
Met Ala Asn Glu Asn His Gly Ser Pro Arg Glu Glu Ala Ser Leu Leu
1 5 10 15
Ser His Ser Pro Gly Thr Ser Asn Gln Ser Gln Pro Cys Ser Pro Lys
20 25 30
Pro Ile Arg Leu Val Gln Asp Leu Pro Glu Glu Leu Val His Ala Gly
35 40 45
Trp Glu Lys Cys Trp Ser Arg Arg Glu Asn Arg Pro Tyr Tyr Phe Asn
50 55 60
Arg Phe Thr Asn Gln Ser Leu Trp Glu Met Pro Val Leu Gly Gln His
65 70 75 80
Asp Val Ile Ser Asp Pro Leu Gly Leu Asn Ala Thr Pro Leu Pro Gln
85 90 95
Asp Ser Ser Leu Val Glu Thr Pro Pro Ala Glu Asn Lys Pro Arg Lys
100 105 110
Arg Gln Leu Ser Glu Glu Gln Pro Ser Gly Asn Gly Val Lys Lys Pro
115 120 125
Lys Ile Glu Ile Pro Val Thr Pro Thr Gly Gln Ser Val Pro Ser Ser
130 135 140
Pro Ser Ile Pro Gly Thr Pro Thr Leu Lys Met Trp Gly Thr Ser Pro
145 150 155 160
Glu Asp Lys Gln Gln Ala Ala Leu Leu Arg Pro Thr Glu Val Tyr Trp
165 170 175
Asp Leu Asp Ile Gln Thr Asn Ala Val Ile Lys His Arg Gly Pro Ser
180 185 190
Glu Val Leu Pro Pro His Pro Glu Val Glu Leu Leu Arg Ser Gln Leu
195 200 205
Ile Leu Lys Leu Arg Gln His Tyr Arg Glu Leu Cys Gln Gln Arg Glu
210 215 220
Gly Ile Glu Pro Pro Arg Glu Ser Phe Asn Arg Trp Met Leu Glu Arg
225 230 235 240
Lys Val Val Asp Lys Gly Ser Asp Pro Leu Leu Pro Ser Asn Cys Glu
245 250 255
Pro Val Val Ser Pro Ser Met Phe Arg Glu Ile Met Asn Asp Ile Pro
260 265 270
Ile Arg Leu Ser Arg Ile Lys Phe Arg Glu Glu Ala Lys Arg Leu Leu
275 280 285
Phe Lys Tyr Ala Glu Ala Ala Arg Arg Leu Ile Glu Ser Arg Ser Ala
290 295 300
Ser Pro Asp Ser Arg Lys Val Val Lys Trp Asn Val Glu Asp Thr Phe
305 310 315 320
Ser Trp Leu Arg Lys Asp His Ser Ala Ser Lys Glu Asp Tyr Met Asp
325 330 335
Arg Leu Glu His Leu Arg Arg Gln Cys Gly Pro His Val Ser Ala Ala
340 345 350
Ala Lys Asp Ser Val Glu Gly Ile Cys Ser Lys Ile Tyr His Ile Ser
355 360 365
Leu Glu Tyr Val Lys Arg Ile Arg Glu Lys His Leu Ala Ile Leu Lys
370 375 380
Glu Asn Asn Ile Ser Glu Glu Val Glu Ala Pro Glu Val Glu Pro Arg
385 390 395 400
Leu Val Tyr Cys Tyr Pro Val Arg Leu Ala Val Ser Ala Pro Pro Met
405 410 415
Pro Ser Val Glu Met His Met Glu Asn Asn Val Val Cys Ile Arg Tyr
420 425 430
Lys Gly Glu Met Val Lys Val Ser Arg Asn Tyr Phe Ser Lys Leu Trp
435 440 445
Leu Leu Tyr Arg Tyr Ser Cys Ile Asp Asp Ser Ala Phe Glu Arg Phe
450 455 460
Leu Pro Arg Val Trp Cys Leu Leu Arg Arg Tyr Gln Met Met Phe Gly
465 470 475 480
Val Gly Leu Tyr Glu Gly Thr Gly Leu Gln Gly Ser Leu Pro Val His
485 490 495
Val Phe Glu Ala Leu His Arg Leu Phe Gly Val Ser Phe Glu Cys Phe
500 505 510
Ala Ser Pro Leu Asn Cys Tyr Phe Arg Gln Tyr Cys Ser Ala Phe Pro
515 520 525
Asp Thr Asp Gly Tyr Phe Gly Ser Arg Gly Pro Cys Leu Asp Phe Ala
530 535 540
Pro Leu Ser Gly Ser Phe Glu Ala Asn Pro Pro Phe Cys Glu Glu Leu
545 550 555 560
Met Asp Ala Met Val Ser His Phe Glu Arg Leu Leu Glu Ser Ser Pro
565 570 575
Glu Pro Leu Ser Phe Ile Val Phe Ile Pro Glu Trp Arg Glu Pro Pro
580 585 590
Thr Pro Ala Leu Thr Arg Met Glu Gln Ser Arg Phe Lys Arg His Gln
595 600 605
Leu Ile Leu Pro Ala Phe Glu His Glu Tyr Arg Ser Gly Ser Gln His
610 615 620
Ile Cys Lys Lys Glu Glu Met His Tyr Lys Ala Val His Asn Thr Ala
625 630 635 640
Val Leu Phe Leu Gln Asn Asp Pro G1y Phe Ala Lys Trp Ala Pro Thr
645 650 655
Pro Glu Arg Leu Gln Glu Leu Ser Ala Ala Tyr Arg Gln Ser Gly Arg
660 665 670
Ser His Ser Ser Gly Ser Ser Ser Ser Ser Ser Ser Glu Ala Lys Asp
675 680 685
Arg Asp Ser Gly Arg Glu Gln Gly Pro Ser Arg Glu Pro His Pro Thr
690 695 700
<210>161
<211>573
<212>PRT
<213>人
<400>161
Met Leu Gly Ser Leu Gly Leu Trp Ala Leu Leu Pro Thr Ala Val Glu
5 10 15
Ala Pro Pro Asn Arg Arg Thr Cys Val Phe Phe Glu Ala Pro Gly Val
20 25 30
Arg Gly Ser Thr Lys Thr Leu Gly Glu Leu Leu Asp Thr Gly Thr Glu
35 40 45
Leu Pro Arg Ala Ile Arg Cys Leu Tyr Ser Arg Cys Cys Phe Gly Ile
50 55 60
Trp Asn Leu Thr Gln Asp Arg Ala Gln Val Glu Met Gln Gly Cys Arg
65 70 75 80
Asp Ser Asp Glu Pro Gly Cys Glu Ser Leu His Cys Asp Pro Ser Pro
85 90 95
Arg Ala His Pro Ser Pro Gly Ser Thr Leu Phe Thr Cys Ser Cys Gly
100 105 110
Thr Asp Phe Cys Asn Ala Asn Tyr Ser His Leu Pro Pro Pro Gly Ser
115 120 125
Pro Gly Thr Pro Gly Ser Gln Gly Pro Gln Ala Ala Pro Gly Glu Ser
130 135 140
lle Trp Met Ala Leu Val Leu Leu Gly Leu Phe Leu Leu Leu Leu Leu
145 150 155 160
Leu Leu Gly Ser Ile Ile Leu Ala Leu Leu Gln Arg Lys Asn Tyr Arg
165 170 175
Val Arg Gly Glu Pro Val Pro Glu Pro Arg Pro Asp Ser Gly Arg Asp
180 185 190
Trp Ser Val Glu Leu Gln Glu Leu Pro Glu Leu Cys Phe Ser Gln Val
195 200 205
lle Arg Glu Gly Gly His Ala Val Val Trp Ala Gly Gln Leu Gln Gly
210 215 220
Lys Leu Val Ala Ile Lys Ala Phe Pro Pro Arg Ser Val Ala Gln Phe
225 230 235 240
Gln Ala Glu Arg Ala Leu Tyr Glu Leu Pro Gly Leu Gln His Asp His
245 250 255
Ile Val Arg Phe Ile Thr Ala Ser Arg Gly Gly Pro Gly Arg Leu Leu
260 265 270
Ser Gly Pro Leu Leu Val Leu Glu Leu His Pro Lys Gly Ser Leu Cys
275 280 285
His Tyr Leu Thr Gln Tyr Thr Ser Asp Trp Gly Ser Ser Leu Arg Met
290 295 300
Ala Leu Ser Leu Ala Gln Gly Leu Ala Phe Leu His Glu Glu Arg Trp
305 310 315 320
Gln Asn Gly Gln Tyr Lys Pro Gly Ile Ala His Arg Asp Leu Ser Ser
325 330 335
Gln Asn Val Leu Ile Arg Glu Asp Gly Ser Cys Ala Ile Gly Asp Leu
340 345 350
Gly Leu Ala Leu Val Leu Pro Gly Leu Thr Gln Pro Pro Ala Trp Thr
355 360 365
Pro Thr Gln Pro Gln Gly Pro Ala Ala Ile Met Glu Ala Gly Thr Gln
370 375 380
Arg Tyr Met Ala Pro Glu Leu Leu Asp Lys Thr Leu Asp Leu Gln Asp
385 390 395 400
Trp Gly Met Ala Leu Arg Arg Ala Asp Ile Tyr Ser Leu Ala Leu Leu
405 410 415
Leu Trp Glu Ile Leu Ser Arg Cys Pro Asp Leu Arg Pro Asp Ser Ser
420 425 430
Pro Pro Pro Phe Gln Leu Ala Tyr Glu Ala Glu Leu Gly Asn Thr Pro
435 440 445
Thr Ser Asp Glu Leu Trp Ala Leu Ala Val Gln Glu Arg Arg Arg Pro
450 455 460
Tyr Ile Pro Ser Thr Trp Arg Cys Phe Ala Thr Asp Pro Asp Gly Leu
465 470 475 480
Arg Glu Leu Leu Glu Asp Cys Trp Asp Ala Asp Pro Glu Ala Arg Leu
485 490 495
Thr Ala Glu Cys Val Gln Gln Arg Leu Ala Ala Leu Ala His Pro Gln
500 505 510
Glu Ser His Pro Phe Pro Glu Ser Cys Pro Arg Gly Cys Pro Pro Leu
515 520 525
Cys Pro Glu Asp Cys Thr Ser Ile Pro Ala Pro Thr Ile Leu Pro Cys
530 535 540
Arg Pro Gln Arg Ser Ala Cys His Phe Ser Val Gln Gln Gly Pro Cys
545 550 555 560
Ser Arg Asn Pro Gln Pro Ala Cys Thr Leu Ser Pro Val
565 570
<210>162
<211>402
<212>PRT
<213>人
<400>162
Met Gly Leu Gly Gln Gly Trp Gly Trp Glu Ala Ser Cys Phe Ala Cys
5 10 15
Leu Ile Arg Ser Cys Cys Gln Val Val Thr Phe Thr Phe Pro Phe Gly
20 25 30
Phe Gln Gly Ile Ser Gln Arg Leu Glu Asn Val Ser Gly Tyr Tyr Ala
35 40 45
Asp Ala Arg Leu Glu Val Gly Ser Thr Gln Leu Arg Thr Ala Gly Ser
50 55 60
Cys Ser His Ser Phe Lys Arg Ser Phe Leu Glu Lys Lys Arg Phe Thr
65 70 75 80
Glu Glu Ala Thr Lys Tyr Phe Arg Glu Arg Val Ser Pro Val His Leu
85 90 95
Gln Ile Leu Leu Thr Asn Asn Glu Ala Trp Lys Arg Phe Val Thr Ala
100 105 110
Ala Glu Leu Pro Arg Asp Glu Ala Asp Ala Leu Tyr Glu Ala Leu Lys
115 120 125
Lys Leu Arg Thr Tyr Ala Ala Ile Glu Asp Glu Tyr Val Gln Gln Lys
130 135 140
Asp Glu Gln Phe Arg Glu Trp Phe Leu Lys Glu Phe Pro Gln Val Lys
145 150 155 160
Arg Lys Ile Gln Glu Ser Ile Glu Lys Leu Arg Ala Leu Ala Asn Gly
165 170 175
Ile Glu Glu Val His Arg Gly Cys Thr Ile Ser Asn Val Val Ser Ser
180 185 190
Ser Thr Gly Ala Ala Ser Gly Ile Met Ser Leu Ala Gly Leu Val Leu
195 200 205
Ala Pro Phe Thr Ala Gly Thr Ser Leu Ala Leu Thr Ala Ala Gly Val
210 215 220
Gly Leu Gly Ala Ala Ser Ala Val Thr Gly Ile Thr Thr Ser Ile Val
225 230 235 240
Glu His Ser Tyr Thr Ser Ser Ala Glu Ala Glu Ala Ser Arg Leu Thr
245 250 255
Ala Thr Ser Ile Asp Arg Leu Lys Val Phe Lys Glu Val Met Arg Asp
260 265 270
Ile Thr Pro Asn Leu Leu Ser Leu Leu Ash Asn Tyr Tyr Glu Ala Thr
275 280 285
Gln Thr Ile Gly Ser Glu Ile Arg Ala Ile Arg Gln Ala Arg Ala Arg
290 295 300
Ala Arg Leu Pro Val Thr Thr Trp Arg Ile Ser Ala Gly Ser Gly Gly
305 310 315 320
Gln Ala Glu Arg Thr Ile Ala Gly Thr Thr Arg Ala Val Ser Arg Gly
325 330 335
Ala Arg Ile Leu Ser Ala Thr Thr Ser Gly Ile Phe Leu Ala Leu Asp
340 345 350
Val Val Asn Leu Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys
355 360 365
Ser Ala Ser Ala Glu Glu Leu Arg Arg Gln Ala Gln Glu Leu Glu Glu
370 375 380
Asn Leu Met Glu Leu Thr Gln Ile Tyr Gln Arg Leu Asn Pro Cys His
385 390 395 400
Thr His
<210>163
<211>326
<212>PRT
<213>人
<400>163
Met Ala Leu Ser Gly Ser Thr Pro Ala Pro Cys Trp Glu Glu Asp Glu
1 5 10 15
Gys Leu Asp Tyr Tyr Gly Met Leu Ser Leu His Arg Met Phe Glu Val
20 25 30
Val Gly Gly Gln Leu Thr Glu Cys Glu Leu Glu Leu Leu Ala Phe Leu
35 40 45
Leu Asp Glu Ala Pro Gly Ala Ala Gly Gly Leu Ala Arg Ala Arg Ser
50 55 60
Gly Leu Glu Leu Leu Leu Glu Leu Glu Arg Arg Gly Gln Cys Asp Glu
65 70 75 80
Ser Asn Leu Arg Leu Leu Gly Gln Leu Leu Arg Val Leu Ala Arg His
85 90 95
Asp Leu Leu Pro His Leu Ala Arg Lys Arg Arg Arg Pro Val Ser Pro
100 105 110
Glu Arg Tyr Ser Tyr Gly Thr Ser Ser Ser Ser Lys Arg Thr Glu Gly
115 120 125
Ser Cys Arg Arg Arg Arg Gln Ser Ser Ser Ser Ala Asn Ser Gln Gln
130 135 140
Gly Gln Trp Glu Thr Gly Ser Pro Pro Thr Lys Arg Gln Arg Arg Ser
145 150 155 160
Arg Gly Arg Pro Ser Gly Gly Ala Arg Arg Arg Arg Arg Gly Ala Pro
165 170 175
Ala Ala Pro Gln Gln Gln Ser Glu Pro Ala Arg Pro Ser Ser Glu Gly
180 185 190
Lys Val Thr Cys Asp Ile Arg Leu Arg Val Arg Ala Glu Tyr Cys Glu
195 200 205
His Gly Pro Ala Leu Glu Gln Gly Val Ala Ser Arg Arg Pro Gln Ala
210 215 220
Leu Ala Arg Gln Leu Asp Val Phe Gly Gln Ala Thr Ala Val Leu Arg
225 230 235 240
Ser Arg Asp Leu Gly Ser Val Val Cys Asp Ile Lys Phe Ser Glu Leu
245 250 255
Ser Tyr Leu Asp Ala Phe Trp Gly Asp Tyr Leu Ser Gly Ala Leu Leu
260 265 270
Gln Ala Leu Arg Gly Val Phe Leu Thr Glu Ala Leu Arg Glu Ala Val
275 280 285
Gly Arg Glu Ala Val Arg Leu Leu Val Ser Val Asp Glu Ala Asp Tyr
290 295 300
Glu Ala Gly Arg Arg Arg Leu Leu Leu Met Glu Glu Glu Gly Gly Arg
305 310 315 320
Arg Pro Thr Glu Ala Ser
325
<210>164
<211>556
<212>PRT
<213>人
<400>164
Met Glu Leu Cys Gly Leu Gly Leu Pro Arg Pro Pro Met Leu Leu Ala
1 5 10 15
Leu Leu Leu Ala Thr Leu Leu Ala Ala Met Leu Ala Leu Leu Thr Gln
20 25 30
Val Ala Leu Val Val Gln Val Ala Glu Ala Ala Arg Ala Pro Ser Val
35 40 45
Ser Ala Lys Pro Gly Pro Ala Leu Trp Pro Leu Pro Leu Ser Val Lys
50 55 60
Met Thr Pro Asn Leu Leu His Leu Ala Pro Glu Asn Phe Tyr Ile Ser
65 70 75 80
His Ser Pro Asn Ser Thr Ala Gly Pro Ser Cys Thr Leu Leu Glu Glu
85 90 95
Ala Phe Arg Arg Tyr His Gly Tyr Ile Phe Gly Phe Tyr Lys Trp His
100 105 110
His Glu Pro Ala Glu Phe Gln Ala Lys Thr Gln Val Gln Gln Leu Leu
115 120 125
Val Ser Ile Thr Leu Gln Ser Glu Cys Asp Ala Phe Pro Asn Ile Ser
130 135 140
Ser Asp Glu Ser Tyr Thr Leu Leu Val Lys Glu Pro Val Ala Val Leu
145 150 155 160
Lys Ala Asn Arg Val Trp Gly Ala Leu Arg Gly Leu Glu Thr Phe Ser
165 170 175
Gln Leu Val Tyr Gln Asp Ser Tyr Gly Thr Phe Thr Ile Asn Glu Ser
180 185 190
Thr Ile Ile Asp Ser Pro Arg Phe Ser Hi s Arg Gly Ile Leu Ile Asp
195 200 205
Thr Ser Arg His Tyr Leu Pro Val Lys Ile Ile Leu Lys Thr Leu Asp
210 215 220
Ala Met Ala Phe Asn Lys Phe Asn Val Leu His Trp His Ile Val Asp
225 230 235 240
Asp Gln Ser Phe Pro Tyr Gln Ser Ile Thr Phe Pro Glu Leu Ser Asn
245 250 255
Lys Gly Ser Tyr Ser Leu Ser His Val Tyr Thr Pro Asn Asp Val Arg
260 265 270
Met Val Ile Glu Tyr Ala Arg Leu Arg Gly Ile Arg Val Leu Pro Glu
275 280 285
Phe Asp Thr Pro Gly His Thr Leu Ser Trp Gly Lys Gly Gln Lys Asp
290 295 300
Leu Leu Thr Pro Cys Tyr Ser Arg Gln Asn Lys Leu Asp Ser Phe Gly
305 310 315 320
Pro Ile Asn Pro Thr Leu Asn Thr Thr Tyr Ser Phe Leu Thr Thr Phe
325 330 335
Phe Lys Glu Ile Ser Glu Val Phe Pro Asp Gln Phe Ile His Leu Gly
340 345 350
Gly Asp Glu Val Glu Phe Lys Cys Trp Glu Ser Asn Pro LysIle Gln
355 360 365
Asp Phe Met Arg Gln Lys Gly Phe Gly Thr Asp Phe Lys Lys Leu Glu
370 375 380
Ser Phe Tyr Ile Gln Lys Val Leu Asp Ile Ile Ala Thr Ile Asn Lys
385 390 395 400
Gly Ser Ile Val Trp Gln Glu Val Phe Asp Asp Lys Ala Lys Leu Ala
405 410 415
Pro Gly Thr Ile Val Glu Val Trp Lys Asp Ser Ala Tyr Pro Glu Glu
420 425 430
Leu Ser Arg Val Thr Ala Ser Gly Phe Pro Val Ile Leu Ser Ala Pro
435 440 445
Trp Tyr Leu Asp Leu Ile Ser Tyr Gly Gln Asp Trp Arg Lys Tyr Tyr
450 455 460
Lys Val Glu Pro Leu Asp Phe Gly Gly Thr Gln Lys Gln Lys Gln Leu
465 470 475 480
Phe Ile Gly Gly Glu Ala Cys Leu Trp Gly Glu Tyr Val Asp Ala Thr
485 490 495
Asn Leu Thr Pro Arg Leu Trp Pro Arg Ala Ser Ala Val Gly Glu Arg
500 505 510
Leu Trp Ser Ser Lys Asp Val Arg Asp Met Asp Asp Ala Tyr Asp Arg
515 520 525
Leu Thr Arg His Arg Cys Arg Met Val Glu Arg Gly Ile Ala Ala Gln
530 535 540
Pro Leu Tyr Ala Gly Tyr Cys Asn His Glu Asn Met
545 550 555
<210>165
<211>463
<212>PRT
<213>人
<400>165
Met Glu Thr Glu Gln Pro Glu Glu Thr Phe Pro Asn Thr Glu Thr Asn
1 5 10 15
Gly Glu Phe Gly Lys Arg Pro Ala Glu Asp Met Glu Glu Glu Gln Ala
20 25 30
Phe Lys Arg Ser Arg Asn Thr Asp Glu Met Val Glu Leu Arg Ile Leu
35 40 45
Leu Gln Ser Lys Asn Ala Gly Ala Val Ile Gly Lys Gly Gly Lys Asn
50 55 60
Ile Lys Ala Leu Arg Thr Asp Tyr Asn Ala Ser Val Ser Val Pro Asp
65 70 75 80
Ser Ser Gly Pro Glu Arg Ile Leu Ser Ile Ser Ala Asp Ile Glu Thr
85 90 95
Ile Gly Glu Ile Leu Lys Lys Ile Ile Pro Thr Leu Glu Glu Gly Leu
100 105 110
Gln Leu Pro Ser Pro Thr Ala Thr Ser Gln Leu Pro Leu Glu Ser Asp
115 120 125
Ala Val Glu Cys Leu Asn Tyr Gln His Tyr Lys Gly Ser Asp Phe Asp
130 135 140
Cys Glu Leu Arg Leu Leu Ile His Gln Ser Leu Ala Gly Gly Ile Ile
145 150 155 160
Gly Val Lys Gly Ala Lys Ile Lys Glu Leu Arg Glu Asn Thr Gln Thr
165 170 175
Thr Ile Lys Leu Phe Gln Glu Cys Cys Pro His Ser Thr Asp Arg Val
180 185 190
Val Leu Ile Gly Gly Lys Pro Asp Arg Val Val Glu Cys Ile Lys Ile
195 200 205
Ile Leu Asp Leu Ile Ser Glu Ser Pro Ile Lys Gly Arg Ala Gln Pro
210 215 220
Tyr Asp Pro Asn Phe Tyr Asp Glu Thr Tyr Asp Tyr Gly Gly Phe Thr
225 230 235 240
Met Met Phe Asp Asp Arg Arg Gly Arg Pro Val Gly Phe Pro Met Arg
245 250 255
Gly Arg Gly Gly Phe Asp Arg Met Pro Pro Gly Arg Gly Gly Arg Pro
260 265 270
Met Pro Pro Ser Arg Arg Asp Tyr Asp Asp Met Ser Pro Arg Arg Gly
275 280 285
Pro Pro Pro Pro Pro Pro Gly Arg Gly Gly Arg Gly Gly Ser Arg Ala
290 295 300
Arg Asn Leu Pro Leu Pro Pro Pro Pro Pro Pro Arg Gly Gly Asp Leu
305 310 315 320
Met Ala Tyr Asp Arg Arg Gly Arg Pro Gly Asp Arg Tyr Asp Gly Met
325 330 335
Val Gly Phe Ser Ala Asp Glu Thr Trp Asp Ser Ala Ile Asp Thr Trp
340 345 350
Ser Pro Ser Glu Trp Gln Met Ala Tyr Glu Pro Gln Gly Gly Ser Gly
355 360 365
Tyr Asp Tyr Ser Tyr Ala Gly Gly Arg Gly Ser Tyr Gly Asp Leu Gly
370 375 380
Gly Pro Ile Ile Thr Thr Gln Val Thr Ile Pro Lys Asp Leu Ala Gly
385 390 395 400
Ser Ile Ile Gly Lys Gly Gly Gln Arg Ile Lys Gln Ile Arg His Glu
405 410 415
Ser Gly Ala Ser Ile Lys Ile Asp Glu Pro Leu Glu Gly Ser Glu Asp
420 425 430
Arg Ile Ile Thr Ile Thr Gly Thr Gln Asp Gln Ile Gln Asn Ala Gln
435 440 445
Tyr Leu Leu Gln Asn Ser Val Lys Gln Tyr Ser Gly Lys Phe Phe
450 455 460
<210>166
<211>538
<212>PRT
<213>人
<400>166
Met Thr Thr Pro Gly Lys Glu Asn Phe Arg Leu Lys Ser Tyr Lys Asn
1 5 10 15
Lys Ser Leu Asn Pro Asp Glu Met Arg Arg Arg Arg Glu Glu Glu Gly
20 25 30
Leu Gln Leu Arg Lys Gln Lys Arg Glu Glu Gln Leu Phe Lys Arg Arg
35 40 45
Asn Val Ala Thr Ala Glu Glu Glu Thr Glu Glu Glu Val Met Ser Asp
50 55 60
Gly Gly Phe His Glu Ala Gln Ile Asn Asn Met Glu Met Ala Pro Gly
65 70 75 80
Gly Val Ile Thr Ser Asp Met Ile Glu Met Ile Phe Ser Lys Ser Pro
85 90 95
Glu Gln Gln Leu Ser Ala Thr Gln Lys Phe Arg Lys Leu Leu Ser Lys
100 105 110
Glu Pro Asn Pro Pro Ile Asp Glu Val Ile Ser Thr Pro Gly Val Val
115 120 125
Ala Arg Phe Val Glu Phe Leu Lys Arg Lys Glu Asn Cys Thr Leu Gln
130 135 140
Phe Glu Ser Ala Trp Val Leu Thr Asn Ile Ala Ser Gly Asn Ser Leu
145 150 155 160
Gln Thr Arg Ile Val Ile Gln Ala Gly Ala Val Pro Ile Phe Ile Glu
165 170 175
Leu Leu Ser Ser Glu Phe Glu Asp Val Gln Glu Gln Ala Val Trp Ala
180 185 190
Leu Gly Asn Ile Ala Gly Asp Ser Thr Met Cys Arg Asp Tyr Val Leu
195 200 205
Asp Cys Asn Ile Leu Pro Pro Leu Leu Gln Leu Phe Ser Lys Gln Asn
210 215 220
Arg Leu Thr Met Thr Arg Asn Ala Val Trp Ala Leu Ser Asn Leu Cys
225 230 235 240
Arg Gly Lys Ser Pro Pro Pro Glu Phe Ala Lys Val Ser Pro Cys Leu
245 250 255
Asn Val Leu Ser Trp Leu Leu Phe Val Ser Asp Thr Asp Val Leu Ala
260 265 270
Asp Ala Cys Trp Ala Leu Ser Tyr Leu Ser Asp Gly Pro Asn Asp Lys
275 280 285
Ile Gln Ala Val Ile Asp Ala Gly Val Cys Arg Arg Leu Val Glu Leu
290 295 300
Leu Met His Asn Asp Tyr Lys Val Val Ser Pro Ala Leu Arg Ala Val
305 310 315 320
Gly Asn Ile Val Thr Gly Asp Asp Ile Gln Thr Gln Val Ile Leu Asn
325 330 335
Cys Ser Ala Leu Gln Ser Leu Leu His Leu Leu Ser Ser Pro Lys Glu
340 345 350
Ser Ile Lys Lys Glu Ala Cys Trp Thr Ile Ser Asn Ile Thr Ala Gly
355 360 365
Asn Arg Ala Gln Ile Gln Thr Val Ile Asp Ala Asn Ile Phe Pro Ala
370 375 380
Leu Ile Ser Ile Leu Gln Thr Ala Glu Phe Arg Thr Arg Lys Glu Ala
385 390 395 400
Ala Trp Ala Ile Thr Asn Ala Thr Ser Gly Gly Ser Ala Glu Gln Ile
405 410 415
Lys Tyr Leu Val Glu Leu Gly Cys Ile Lys Pro Leu Cys Asp Leu Leu
420 425 430
Thr Val Met Asp Ser Lys Ile Val Gln Val Ala Leu Asn Gly Leu Glu
435 440 445
Asn Ile Leu Arg Leu Gly Glu Gln Glu Ala Lys Arg Asn Gly Thr Gly
450 455 460
Ile Asn Pro Tyr Cys Ala Leu Ile Glu Glu Ala Tyr Gly Leu Asp Lys
465 470 475 480
Tle Glu Phe Leu Gln Ser His Glu Asn Gln Glu Ile Tyr Gln Lys Ala
485 490 495
Phe Asp Leu Ile Glu His Tyr Phe Gly Thr Glu Asp Glu Asp Ser Ser
500 505 510
Ile Ala Pro Gln Val Asp Leu Asn Gln Gln Gln Tyr Ile Phe Gln Gln
515 520 525
Cys Glu Ala Pro Met Glu Gly Phe Gln Leu
530 535
<210>167
<211>261
<212>PRT
<213>人
<400>167
Met Asn Pro Asn Cys Ala Arg Cys Gly Lys Ile Val Tyr Pro Thr Glu
1 5 10 15
Lys Val Asn Cys Leu Asp Lys Phe Trp His Lys Ala Cys Phe His Cys
20 25 30
Glu Thr Cys Lys Met Thr Leu Asn Met Lys Asn Tyr Lys Gly Tyr Glu
35 40 45
Lys Lys Pro Tyr Cys Asn Ala His Tyr Pro Lys Gln Ser Phe Thr Met
50 55 60
Val Ala Asp Thr Pro Glu Asn Leu Arg Leu Lys Gln Gln Ser Glu Leu
65 70 75 80
Gln Ser Gln Val Arg Tyr Lys Glu Glu Phe Glu Lys Asn Lys Gly Lys
85 90 95
Gly Phe Ser Val Val Ala Asp Thr Pro Glu Leu Gln Arg Ile Lys Lys
100 105 110
Thr Gln Asp Gln Ile Ser Asn Ile Lys Tyr His Glu Glu Phe Glu Lys
115 120 125
Ser Arg Met Gly Pro Ser Gly Gly Glu Gly Met Glu Pro Glu Arg Arg
130 135 140
Asp Ser Gln Asp Gly Ser Ser Tyr Arg Arg Pro Leu Glu Gln Gln Gln
145 150 155 160
Pro His His Ile Pro Thr Ser Ala Pro Val Tyr Gln Gln Pro Gln Gln
165 170 175
Gln Pro Val Ala Gln Ser Tyr Gly Gly Tyr Lys Glu Pro Ala Ala Pro
180 185 190
Val Ser Ile Gln Arg Ser Ala Pro Gly Gly Gly Gly Lys Arg Tyr Arg
195 200 205
Ala Val Tyr Asp Tyr Ser Ala Ala Asp Glu Asp Glu Val Ser Phe Gln
210 215 220
Asp Gly Asp Thr Ile Val Asn Val Gln Gln Ile Asp Asp Gly Trp Met
225 230 235 240
Tyr Gly Thr Val Glu Arg Thr Gly Asp Thr Gly Met Leu Pro Ala Asn
245 250 255
Tyr Val Glu Ala Ile
260
<210>168
<211>372
<212>PRT
<213>人
<400>168
Met Ser Leu Arg Cys Gly Asp Ala Ala Arg Thr Leu Gly Pro Arg Val
1 5 10 15
Phe Gly Arg Tyr Phe Cys Ser Pro Val Arg Pro Leu Ser Ser Leu Pro
20 25 30
Asp Lys Lys Lys Glu Leu Leu Gln Asn Gly Pro Asp Leu Gln Asp Phe
35 40 45
Val Ser Gly Asp Leu Ala Asp Arg Ser Thr Trp Asp Glu Tyr Lys Gly
50 55 60
Asn Leu Lys Arg Gln Lys Gly Glu Arg Leu Arg Leu Pro Pro Trp Leu
65 70 75 80
Lys Thr Glu Ile Pro Met Gly Lys Asn Tyr Asn Lys Leu Lys Asn Thr
85 90 95
Leu Arg Asn Leu Asn Leu His Thr Val Cys Glu Glu Ala Arg Cys Pro
100 105 110
Asn Ile Gly Glu Cys Trp Gly Gly Gly Glu Tyr Ala Thr Ala Thr Ala
115 120 125
Thr Ile Met Leu Met Gly Asp Thr Cys Thr Arg Gly Cys Arg Phe Cys
130 135 140
Ser Val Lys Thr Ala Arg Asn Pro Pro Pro Leu Asp Ala Ser Glu Pro
145 150 155 160
Tyr Asn Thr Ala Lys Ala Ile Ala Glu Trp Gly Leu Asp Tyr Val Val
165 170 175
Leu Thr Ser Val Asp Arg Asp Asp Mer Pro Asp Gly Gly Ala Glu His
180 185 190
Ile Ala Lys Thr Val Ser Tyr Leu Lys Glu Arg Asn Pro Lys Ile Leu
195 200 205
Val Glu Cys Leu Thr Pro Asp Phe Arg Gly Asp Leu Lys Ala Ile Glu
210 215 220
Lys Val Ala Leu Ser Gly Leu Asp Val Tyr Ala His Asn Val Glu Thr
225 230 235 240
Val Pro Glu Leu Gln Ser Lys Val Arg Asp Pro Arg Val Asn Phe Asp
245 250 255
Gln Ser Leu Arg Val Leu Lys His Ala Lys Lys Val Gln Pro Asp Val
260 265 270
Ile Ser Lys Thr Ser Ile Met Leu Gly Leu Gly Glu Asn Asp Glu Gln
275 280 285
Val Tyr Ala Thr Met Lys Ala Leu Arg Glu Ala Asp Val Asp Cys Leu
290 295 300
Thr Leu Gly Gln Tyr Met Gln Pro Thr Arg Arg His Leu Lys Val Glu
305 310 315 320
Glu Tyr Ile Thr Pro Glu Lys Phe Lys Tyr Trp Glu Lys Val Gly Asn
325 330 335
Glu Leu Gly Phe His Tyr Thr Ala Ser Gly Pro Leu Val Arg Ser Ser
340 345 350
Tyr Lys Ala Gly Glu Phe Phe Leu Lys Asn Leu Val Ala Lys Arg Lys
355 360 365
Thr Lys Asp Leu
370
<210>169
<211>643
<212>PRT
<213>人
<400>169
Met Leu Leu Pro Cys His Trp Val Leu Asp Ala Thr Phe Ser Asp Gly
1 5 10 15
Ser Leu Gly Gln Trp Val Lys Asn Thr Cys Ala Thr Tyr Ala Leu Ser
20 25 30
Pro Val Val Leu Pro Pro Gln Pro Gln Pro Arg Lys Lys Ala Thr Asp
35 40 45
Lys Asp Tyr Ser Ala Phe His Leu Gly His Leu Arg Glu Val Arg Leu
50 55 60
Phe Leu Arg Gly Gly Thr Ser Asp Gln Arg Met Asp Ser Leu Val Leu
65 70 75 80
Cys Pro Thr Tyr Phe Lys Leu Trp Arg Thr Leu Ser Gly Ser Pro Gly
85 90 95
Leu Gln Leu Ser Asp Leu His Phe Gly Ser Gln Pro Glu Gly Lys Phe
100 105 110
Ser Leu Arg Arg Ala Val Ser Val Lys Gln Arg Glu Glu Pro Gln Asp
115 120 125
Trp Pro Leu Asn Glu Lys Arg Thr Leu Trp Lys Asp Ser Asp Leu Pro
130 135 140
Thr Trp Arg Arg Gly Thr Gly Tyr Thr Leu Ser Leu Pro Ala Val Ser
145 150 155 160
Pro Gly Lys Arg Leu Trp Gly Glu Lys Ala Gly Ser Leu Pro Glu Ser
165 170 175
Glu Pro Leu Phe Thr Tyr Thr Leu Asp Glu Lys Val Asp Lys Leu Val
180 185 190
Gln Phe Leu Leu Leu Lys Tyr Gln Ala Lys Glu Pro Leu Thr Arg Ala
195 200 205
Glu Met Gln Met Asn Val Ile Asn Thr Tyr Thr Gly Tyr Phe Pro Met
210 215 220
Ile Phe Arg Lys Ala Arg Glu Phe Ile Glu Ile Leu Phe Gly Ile Ser
225 230 235 240
Leu Thr Glu Val Asp Pro Asp His Phe Tyr Val Phe Val Asn Thr Leu
245 250 255
Asp Leu Thr Cys Glu Gly Ser Leu Ser Asp Glu Gln Gly Met Pro Gln
260 265 270
Asn Arg Leu Leu Ile Leu Ile Leu Ser Val Ile Phe Ile Lys Gly Asn
275 280 285
Cys Ala Ser Glu Glu Val Ile Trp Glu Val Leu Asn Ala Ile Gly Pro
290 295 300
Trp Ser Ala Leu Ala Gly Phe Ala Asp Val Leu Ser Arg Leu Ala Leu
305 310 315 320
Trp Glu Ser Glu Gly Pro Glu Ala Phe Cys Glu Glu Ser Gly Leu Arg
325 330 335
Ser Ala Glu Gly Ser Val Leu Asp Leu Ala Asn Pro Gln Gly Leu Ala
340 345 350
Gly His Arg Gln Glu Asp Gly Arg Arg Gly Leu Thr Glu Ala Ser Pro
355 360 365
Gln Gln Lys Lys Gly Gly Glu Asp Glu Asp Met Pro Ala Ala Gly Met
370 375 380
Pro Pro Leu Pro Gln Ser Pro Pro Glu Ile Pro Pro Gln Gly Pro Pre
385 390 395 400
Lys Ile Ser Pro Gln Gly Pro Pro Gln Ser Pro Pro Gln Ser Pro Leu
405 410 415
Asp Ser Cys Ser Ser Pro Leu Leu Trp Thr Arg Leu Asp Glu Glu Ser
420 425 430
Ser Ser Glu Glu Glu Asp Thr Ala Thr Trp His Ala Leu Pro Glu Ser
435 440 445
Glu Ser Leu Pro Arg Tyr Ala Leu Asp Glu Lys Val Ala Glu Leu Val
450 455 460
Gln Phe Leu Leu Leu Lys Tyr Gln Thr Lys Glu Pro Val Thr Lys Ala
465 470 475 480
Glu Met Leu Thr Thr Val Ile Lys Lys Tyr Lys Asp Tyr Phe Pro Met
485 490 495
Ile Phe Gly Lys Ala His Glu Phe Ile Glu Leu Ile Phe Gly Ile Ala
500 505 510
Leu Thr Asp Met Asp Pro Asp Asn His Ser Tyr Phe Phe Glu Asp Thr
515 520 525
Leu Asp Leu Thr Tyr Glu Gly Ser Leu Ile Asp Asp Gln Gly Met Pro
530 535 540
Lys Asn Cys Leu Leu Ile Leu Ile Leu Ser Met Ile Phe Ile Lys Gly
545 550 555 560
Ser Cys Val Pro Glu Glu Val Ile Trp Glu Val Leu Ser Ala Ile Gly
565 570 575
Pro Ile Gln Arg Pro Ala Arg Glu Val Leu Glu Phe Leu Ser Lys Leu
580 585 590
Ser Ser Ile Ile Pro Ser Ala Phe Pro Ser Trp Tyr Met Asp Ala Leu
595 600 605
Lys Asp Met Glu Asp Arg Ala Gln Ala Ile Ile Asp Thr Thr Asp Asp
610 615 620
Ala Thr Ala Met Ala Ser Ala Ser Pro Ser Val Met Ser Thr Asn Phe
625 630 635 640
Cys Pro Glu
<210>170
<211>902
<212>PRT
<213>人
<400>170
Met Gly Ala Ala Ser Cys Glu Asp Glu Glu Leu Glu Phe Lys Leu Val
1 5 10 15
Phe Gly Glu Glu Lys Glu Ala Pro Pro Leu Gly Ala Gly Gly Leu Gly
20 25 30
Glu Glu Leu Asp Ser Glu Asp Ala Pro Pro Cys Cys Arg Leu Ala Leu
35 40 45
Gly Glu Pro Pro Pro Tyr Gly Ala Ala Pro Ile Gly Ile Pro Arg Pro
50 55 60
Pro Pro Pro Arg Pro Gly Met His Ser Pro Pro Pro Arg Pro Ala Pro
65 70 75 80
Ser Pro Gly Thr Trp Glu Ser Gln Pro Ala Arg Ser Val Arg Leu Gly
85 90 95
Gly Pro Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly Arg Val Leu Glu
100 105 110
Cys Pro Ser Ile Arg Ile Thr Ser Ile Ser Pro Thr Pro Glu Pro Pro
115 120 125
Ala Ala Leu Glu Asp Asn Pro Asp Ala Trp Gly Asp Gly Ser Pro Arg
130 135 140
Asp Tyr Pro Pro Pro Glu Gly Phe Gly Gly Tyr Arg Glu Ala Gly Ala
145 150 155 160
Gln Gly Gly Gly Ala Phe Phe Ser Pro Ser Pro Gly Ser Ser Ser Leu
165 170 175
Ser Ser Trp Ser Phe Phe Ser Asp Ala Ser Asp Glu Ala Ala Leu Tyr
180 185 190
Ala Ala Cys Asp Glu Val Glu Ser Glu Leu Asn Glu Ala Ala Ser Arg
195 200 205
Phe Gly Leu Gly Ser Pro Leu Pro Ser Pro Arg Ala Ser Pro Arg Pro
210 215 220
Trp Thr Pro Glu Asp Pro Trp Ser Leu Tyr Gly Pro Ser Pro Gly Gly
225 230 235 240
Arg Gly Pro Glu Asp Ser Trp Leu Leu Leu Ser Ala Pro Gly Pro Thr
245 250 255
Pro Ala Ser Pro Arg Pro Ala Ser Pro Cys Gly Lys Arg Arg Tyr Ser
260 265 270
Ser Ser Gly Thr Pro Ser Ser Ala Ser Pro Ala Leu Ser Arg Arg Gly
275 280 285
Ser Leu Gly Glu Glu Gly Ser Glu Pro Pro Pro Pro Pro Pro Leu Pro
290 295 300
Leu Ala Arg Asp Pro Gly Ser Pro Gly Pro Phe Asp Tyr Val Gly Ala
305 310 315 320
Pro Pro Ala Glu Ser Ile Pro Gln Lys Thr Arg Arg Thr Ser Ser Glu
325 330 335
Gln Ala Val Ala Leu Pro Arg Ser Glu Glu Pro Ala Ser Cys Asn Gly
340 345 350
Lys Leu Pro Leu Gly Ala Glu Glu Ser Val Ala Pro Pro Gly Gly Ser
355 360 365
Arg Lys Glu Val Ala Gly Met Asp Tyr Leu Ala Val Pro Ser Pro Leu
370 375 380
Ala Trp ser Lys Ala Arg Ile Gly Gly His Ser Pro Ile Phe Arg Thr
385 390 395 400
Ser Ala Leu Pro Pro Leu Asp Trp Pro Leu Pro Ser Gln Tyr Glu Gln
405 410 415
Leu Glu Leu Arg Ile Glu Val Gln Pro Arg Ala His His Arg Ala His
420 425 430
Tyr Glu Thr Glu Gly Ser Arg Gly Ala Val Lys Ala Ala Pro Gly Gly
435 440 445
His Pro Val Val Lys Leu Leu Gly Tyr Ser Glu Lys Pro Leu Thr Leu
450 455 460
Gln Met Phe Ile Gly Thr Ala Asp Glu Arg Asn Leu Arg Pro His Ala
465 470 475 480
Phe Tyr Gln Val His Arg Ile Thr Gly Lys Met Val Ala Thr Ala Ser
485 490 495
Tyr Glu Ala Val Val Ser Gly Thr Lys Val Leu Glu Met Thr Leu Leu
500 505 510
Pro Glu Asn Asn Met Ala Ala Asn Ile Asp Cys Ala Gly Ile Leu Lys
515 520 525
Leu Arg Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly
530 535 540
Arg Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val His Val Pro Gln
545 550 555 560
Gly Gly Gly Lys Val Val Ser Val Gln Ala Ala Ser Val Pro Ile Glu
565 570 575
Cys Ser Gln Arg Ser Ala Gln Glu Leu Pro Gln Val Glu Ala Tyr Ser
580 585 590
Pro Ser Ala Cys Ser Val Arg Gly Gly Glu Glu Leu Val Leu Thr Gly
595 600 605
Ser Asn Phe Leu Pro Asp Ser Lys Val Val Phe Ile Glu Arg Gly Pro
610 615 620
Asp Gly Lys Leu Gln Trp Glu Glu Glu Ala Thr Val Asn Arg Leu Gln
625 630 635 640
Ser Asn Glu Val Thr Leu Thr Leu Thr Val Pro Glu Tyr Ser Asn Lys
645 650 655
Arg Val Ser Arg Pro Val Gln Val Tyr Phe Tyr Val Ser Asn Gly Arg
660 665 670
Arg Lys Arg Ser Pro Thr Gln Ser Phe Arg Phe Leu Pro Val Ile Cys
675 680 685
Lys Glu Glu Pro Leu Pro Asp Ser Ser Leu Arg Gly Phe Pro Ser Ala
690 695 700
Ser Ala Thr Pro Phe Gly Thr Asp Met Asp Phe Ser Pro Pro Arg Pro
705 710 715 720
Pro Tyr Pro Ser Tyr Pro His Glu Asp Pro Ala Cys Glu Thr Pro Tyr
725 730 735
Leu Ser Glu Gly Phe Gly Tyr Gly Met Pro Pro Leu Tyr Pro Gln Thr
740 745 750
Gly Pro Pro Pro Ser Tyr Arg Pro Gly Leu Arg Met Phe Pro Glu Thr
755 760 765
Arg Gly Thr Thr Gly Cys Ala Gln Pro Pro Ala Val Ser Phe Leu Pro
770 775 780
Arg Pro Phe Pro Ser Asp Pro Tyr Gly Gly Arg Gly Ser Ser Phe Pro
785 790 795 800
Leu Gly Leu Pro Phe Ser Pro Pro Ala Pro Phe Arg Pro Pro Pro Leu
805 810 815
Pro Ala Ser Pro Pro Leu Glu Gly Pro Phe Pro Ser Gln Ser Asp Val
820 825 830
His Pro Leu Pro Ala Glu Gly Tyr Asn Lys Val Gly Pro Gly Tyr Gly
835 840 845
Pro Gly Glu Gly Ala Pro Glu Gln Glu Lys Ser Arg Gly Gly Tyr Ser
850 855 860
Ser Gly Phe Arg Asp Ser Val Pro Ile Gln Gly Ile Thr Leu Glu Glu
865 870 875 880
Val Ser Glu Ile Ile Gly Arg Asp Leu Ser Gly Phe Pro Ala Pro Pro
885 890 895
Gly Glu Glu Pro Pro Ala
900
<210>171
<211>478
<212>PRT
<213>人
<400>171
Met Ser Pro Pro Leu Leu Lys Leu Gly Ala Val Leu Ser Thr Met Ala
1 5 10 15
Met Ile Ser Asn Trp Met Ser Gln Thr Leu Pro Ser Leu Val Gly Leu
20 25 30
Asn Thr Thr Arg Leu Ser Thr Pro Asp Thr Leu Thr Gln Ile Ser Pro
35 40 45
Lys Glu Gly Trp Gln Val Tyr Ser Ser Ala Gln Asp Pro Asp Gly Arg
50 55 60
Cys Ile Cys Thr Val Val Ala Pro Glu Gln Asn Leu Cys Ser Arg Asp
65 70 75 80
Ala Lys Ser Arg Gln Leu Arg Gln Leu Leu Glu Lys Val Gln Asn Met
85 90 95
Ser Gln Ser Ile Glu Val Leu Asn Leu Arg Thr Gln Arg Asp Phe Gln
100 105 110
Tyr Val Leu Lys Met Glu Thr Gln Met Lys Gly Leu Lys Ala Lys Phe
115 120 125
Arg Gln Ile Glu Asp Asp Arg Lys Thr Leu Met Thr Lys His Phe Gln
130 135 140
Glu Leu Lys Glu Lys Met Asp Glu Leu Leu Pro Leu Ile Pro Val Leu
145 150 155 160
Glu Gln Tyr Lys Thr Asp Ala Lys Leu Ile Thr Gln Phe Lys Glu Glu
165 170 175
Ile Arg Asn Leu Ser Ala Val Leu Thr Gly Ile Gln Glu Glu Ile Gly
180 185 190
Ala Tyr Asp Tyr Glu Glu Leu His Gln Arg Val Leu Ser Leu Glu Thr
195 200 205
Arg Leu Arg Asp Cys Met Lys Lys Leu Thr Cys Gly Lys Leu Met Lys
210 215 220
Ile Thr Gly Pro Val Thr Val Lys Thr Ser Gly Thr Arg Phe Gly Ala
225 230 235 240
Trp Met Thr Asp Pro Leu Ala Ser Glu Lys Asn Asn Arg Val Trp Tyr
245 250 255
Met Asp Ser Tyr Thr Asn Asn Lys Ile Val Arg Glu Tyr Lys Ser Ile
260 265 270
Ala Asp Phe Val Ser Gly Ala Glu Ser Arg Thr Tyr Asn Leu Pro Phe
275 280 285
Lys Trp Ala Gly Thr Asn His Val Val Tyr Asn Gly Ser Leu Tyr Phe
290 295 300
Asn Lys Tyr Gln Ser Asn Ile Ile Ile Lys Tyr Ser Phe Asp Met Gly
305 310 315 320
Arg Val Leu Ala Gln Arg Ser Leu Glu Tyr Ala Gly Phe His Asn Val
325 330 335
Tyr Pro Tyr Thr Trp Gly Gly Phe Ser Asp Ile Asp Leu Met Ala Asp
340 345 350
Glu Ile Gly Leu Trp Ala Val Tyr Ala Thr Asn Gln Asn Ala Gly Asn
355 360 365
Ile Val Ile Ser Gln Leu Asn Gln Asp Thr Leu Glu Val Met Lys Ser
370 375 380
Trp Ser Thr Gly Tyr Pro Lys Arg Ser Ala Gly Glu Ser Phe Met Ile
385 390 395 400
Cys Gly Thr Leu Tyr Val Thr Asn Ser His Leu Thr Gly Ala Lys Val
405 410 415
Tyr Tyr Ser Tyr Ser Thr Lys Thr Ser Thr Tyr Glu Tyr Thr Asp Ile
420 425 430
Pro Phe His Asn Gln Tyr Phe His Ile Ser Met Leu Asp Tyr Asn Ala
435 440 445
Arg Asp Arg Ala Leu Tyr Ala Trp Asn Asn Gly His Gln Val Leu Phe
450 455 460
Asn Val Thr Leu Phe His Ile Ile Lys Thr Glu Asp Asp Thr
465 470 475
<210>172
<211>316
<212>PRT
<213>人
<400>172
Met Ala Glu Val Lys Val Lys Val Gln Pro Pro Asp Ala Asp Pro Val
1 5 10 15
Glu Ile Glu Asn Arg Ile Ile Glu Leu Cys His Gln Phe Pro His Gly
20 25 30
Ile Thr Asp Gln Val Ile Gln Asn Glu Met Pro His Ile Glu Ala Gln
35 40 45
Gln Arg Ala Val Ala Ile Asn Arg Leu Leu Ser Met Gly Gln Leu Asp
50 55 60
Leu Leu Arg Ser Asn Thr Gly Leu Leu Tyr Arg Ile Lys Asp Ser Gln
65 70 75 80
Asn Ala Gly Lys Met Lys Gly Ser Asp Asn Gln Glu Lys Leu Val Tyr
85 90 95
Gln Ile Ile Glu Asp Ala Gly Asn Lys Gly Ile Trp Ser Arg Asp Ile
100 105 110
Arg Tyr Lys Ser Asn Leu Pro Leu Thr Glu Ile Asn Lys Ile Leu Lys
115 120 125
Asn Leu Glu Ser Lys Lys Leu Ile Lys Ala Val Lys Ser Val Ala Ala
130 135 140
Ser Lys Lys Lys Val Tyr Met Leu Tyr Asn Leu Gln Pro Asp Arg Ser
145 150 155 160
Val Thr Gly Gly Ala Trp Tyr Ser Asp Gln Asp Phe Glu Ser Glu Phe
165 170 175
Val Glu Val Leu Asn Gln Gln Cys Phe Lys Phe Leu Gln Ser Lys Ala
180 185 190
Glu Thr Ala Arg Glu Ser Lys Gln Asn Pro Met Ile Gln Arg Asn Ser
195 200 205
Ser Phe Ala Ser Ser His Glu Val Trp Lys Tyr Ile Cys Glu Leu Gly
210 215 220
Ile Ser Lys Val Glu Leu Ser Met Glu Asp Ile Glu Thr Ile Leu Asn
225 230 235 240
Thr Leu Ile Tyr Asp Gly Lys Val Glu Met Thr Ile Ile Ala Ala Lys
245 250 255
Glu Gly Thr Val Gly Ser Val Asp Gly His Met Lys Leu Tyr Arg Ala
260 265 270
Val Asn Pro Ile Ile Pro Pro Thr Gly Leu Val Arg Ala Pro Cys Gly
275 280 285
Leu Cys Pro Val Phe Asp Asp Cys His Glu Gly Gly GluIle Ser Pro
290 295 300
Ser Asn Cys Ile Tyr Met Thr Glu Trp Leu Glu Phe
305 310 315
<210>173
<211>524
<212>PRT
<213>人
<400>173
Met Ala Ala Pro Glu Pro Ala Arg Ala Ala Pro Pro Pro Pro Pro Pro
1 5 10 15
Pro Pro Pro Pro Pro Gly Ala Asp Arg Val Val Lys Ala Val Pro Phe
20 25 30
Pro Pro Thr His Arg Leu Thr Ser Glu Glu Val Phe Asp Leu Asp Gly
35 40 45
Ile Pro Arg Val Asp Val Leu Lys Asn His Leu Val Lys Glu Gly Arg
50 55 60
Val Asp Glu Glu Ile Ala Leu Arg Ile Ile Asn Glu Gly Ala Ala Ile
65 70 75 80
Leu Arg Arg Glu Lys Thr Met Ile Glu Val Glu Ala Pro Ile Thr Val
85 90 95
Cys Gly Asp Ile His Gly Gln Phe Phe Asp Leu Met Lys Leu Phe Glu
100 105 110
Val Gly Gly Ser Pro Ala Asn Thr Arg Tyr Leu Phe Leu Gly Asp Tyr
115 120 125
Val Asp Arg Gly Tyr Phe Ser Ile Glu Cys Val Leu Tyr Leu Trp Val
130 135 140
Leu Lys Ile Leu Tyr Pro Ser Thr Leu Phe Leu Leu Arg Gly Asn His
145 150 155 160
Glu Cys Arg His Leu Thr Glu Tyr Phe Thr Phe Lys Gln Glu Cys Lys
165 170 175
Ile Lys Tyr Ser Glu Arg Val Tyr Glu Ala Cys Met Glu Ala Phe Asp
180 185 190
Ser Leu Pro Leu Ala Ala Leu Leu Asn Gln Gln Phe Leu Cys Val His
195 200 205
Gly Gly Leu Ser Pro Glu Ile His Thr Leu Asp Asp Ile Arg Arg Leu
210 215 220
Asp Arg Phe Lys Glu Pro Pro Ala Phe Gly Pro Met Cys Asp Leu Leu
225 230 235 240
Trp Ser Asp Pro Ser Glu Asp Phe Gly Asn Glu Lys Ser Gln Glu His
245 250 255
Phe Ser His Asn Thr Val Arg Gly Cys Ser Tyr Phe Tyr Asn Tyr Pro
260 265 270
Ala Val Cys Glu Phe Leu Gln Asn Asn Asn Leu Leu Ser Ile Ile Arg
275 280 285
Ala His Glu Ala Gln Asp Ala Gly Tyr Arg Met Tyr Arg Lys Ser Gln
290 295 300
Thr Thr Gly Phe Pro Ser Leu Ile Thr Ile Phe Ser Ala Pro Asn Tyr
305 310 315 320
Leu Asp Val Tyr Asn Asn Lys Ala Ala Val Leu Lys Tyr Glu Asn Asn
325 330 335
Val Met Asn Ile Arg Gln Phe Asn Cys Ser Pro His Pro Tyr Trp Leu
340 345 350
Pro Asn Phe Met Asp Val Phe Thr Trp Ser Leu Pro Phe Val Gly Glu
355 360 365
Lys Val Thr Glu Met Leu Val Asn Val Leu Ser Ile Cys Ser Asp Asp
370 375 380
Glu Leu Met Thr Glu Gly Glu Asp Gln Phe Asp Gly Ser Ala Ala Ala
385 390 395 400
Ara Lys Glu Ile Ile Arg Asn Lys Ile Arg Ala Ile Gly Lys Met Ala
405 410 415
Arg Val Phe Ser Val Leu Arg Glu Glu Ser Glu Ser Val Leu Thr Leu
420 425 430
Lys Gly Leu Thr Pro Thr Gly Met Leu Pro Ser Gly Val Leu Ala Gly
435 440 445
Gly Arg Gln Thr Leu Gln Ser Ala Thr Val Glu Ala Ile Glu Ala Glu
450 455 460
Lys Ala Ile Arg Gly Phe Ser Pro Pro His Arg Ile Cys Ser Phe Glu
465 470 475 480
Glu Ala Lys Gly Leu Asp Arg Ile Asn Glu Arg Met Pro Pro Arg Lys
485 490 495
Asp Ala Val Gln Gln Asp Gly Phe Asn Ser Leu Asn Thr Ala His Ala
500 505 510
Thr Glu Asn His Gly Thr Gly Asn His Thr Ala Gln
515 520
<210>174
<211>639
<212>PRT
<213>人
<400>174
Met Ala Thr Gly Ala Asn Ala Thr Pro Leu Asp Phe Pro Ser Lys Lys
1 5 10 15
Arg Lys Arg Ser Arg Trp Asn Gln Asp Thr Met Glu Gln Lys Thr Val
20 25 30
Ile Pro Gly Met Pro Thr Val Ile Pro Pro Gly Leu Thr Arg Glu Gln
35 40 45
Glu Arg Ala Tyr Ile Val Gln Leu Gln Ile Glu Asp Leu Thr Arg Lys
50 55 60
Leu Arg Thr Gly Asp Leu Gly Ile Pro Pro Asn Pro Glu Asp Arg Ser
65 70 75 80
Pro Ser Pro Glu Pro Ile Tyr Asn Ser Glu Gly Lys Arg Leu Asn Thr
85 90 95
Arg Glu Phe Arg Thr Arg Lys Lys Leu Glu Glu Glu Arg His Asn Leu
100 105 110
Ile Thr Glu Met Val Ala Leu Asn Pro Asp Phe Lys Pro Pro Ala Asp
115 120 125
Tyr Lys Pro Pro Ala Thr Arg Val Ser Asp Lys Val Met Ile Pro Gln
150 135 140
Asp Glu Tyr Pro Glu Ile Asn Phe Val Gly Leu Leu Ile Gly Pro Arg
145 150 155 160
Gly Asn Thr Leu Lys Asn Ile Glu Lys Glu Cys Asn Ala Lys Ile Met
165 170 175
Ile Arg Gly Lys Gly Ser Val Lys Glu Gly Lys Val Gly Arg Lys Asp
180 185 190
Gly Gln Met Leu Pro Gly Glu Asp Glu Pro Leu His Ala Leu Val Thr
195 200 205
Ala Asn Thr Met Glu Asn Val Lys Lys Ala Val Glu Gln Ile Arg Asn
210 215 220
Ile Leu Lys Gln Gly Ile Glu Thr Pro Glu Asp Gln Asn Asp Leu Arg
225 230 235 240
Lys Met Gln Leu Arg Glu Leu Ala Arg Leu Asn Gly Thr Leu Arg Glu
245 250 255
Asp Asp Asn Arg Ile Leu Arg Pro Trp Gln Ser Ser Glu Thr Arg Ser
260 265 270
Ile Thr Asn Thr Thr Val Cys Thr Lys Cys Gly Gly Ala Gly His Ile
275 280 285
Ala Ser Asp Cys Lys Phe Gln Arg Pro Gly Asp Pro Gln Ser Ala Gln
290 295 300
Asp Lys Ala Arg Met Asp Lys Glu Tyr Leu Ser Leu Met Ala Glu Leu
305 310 315 320
Gly Glu Ala Pro Val Pro Ala Ser Val Gly Ser Thr Ser Gly Pro Ala
325 330 335
Thr Thr Pro Leu Ala Ser Ala Pro Arg Pro Ala Ala Pro Ala Asn Asn
340 345 350
Pro Pro Pro Pro Ser Leu Met Ser Thr Thr Gln Ser Arg Pro Pro Trp
355 360 365
Met Asn Ser Gly Pro Ser Glu Ser Arg Pro Tyr His Gly Met His Gly
370 375 380
Gly Gly Pro Gly Gly Pro Gly Gly Gly Pro His Ser Phe Pro His Pro
385 390 395 400
Leu Pro Ser Leu Thr Gly Gly His Gly Gly His Pro Met Gln His Asn
405 410 415
Pro Asn Gly Pro Pro Pro Pro Trp Met Gln Pro Pro Pro Pro Pro Met
420 425 430
Asn Gln Gly Pro His Pro Pro Gly His His Gly Pro Pro Pro Met Asp
435 440 445
Gln Tyr Leu Gly Ser Thr Pro Val Gly Ser Gly Val Tyr Arg Leu His
450 455 460
Gln Gly Lys Gly Met Met Pro Pro Pro Pro Met Gly Met Met Pro Pro
465 470 475 480
Pro Pro Pro Pro Pro Ser Gly Gln Pro Pro Pro Pro Pro Ser Gly Pro
485 490 495
Leu Pro Pro Trp Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro
500 505 510
Pro Ser Ser Ser Met Ala Ser Ser Thr Pro Leu Pro Trp Gln Gln Asn
515 520 525
Thr Thr Thr Thr Thr Thr Ser Ala Gly Thr Gly Ser Ile Pro Pro Trp
530 535 540
Gln Gln Gln Gln Ala Ala Ala Ala Ala Ser Pro Gly Ala Pro Gln Met
545 550 555 560
Gln Gly Asn Pro Thr Met Val Pro Leu Pro Pro Gly Val Gln Pro Pro
565 570 575
Leu Pro Pro Gly Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Ser
580 585 590
Ala Gly Met Met Tyr Ala Pro Pro Pro Pro Pro Pro Pro Pro Met Asp
595 600 605
Pro Ser Asn Phe Val Thr Met Met Gly Met Gly Val Ala Gly Met Pro
610 615 620
Pro Phe Gly Met Pro Pro Ala Pro Pro Pro Pro Pro Pro Gln Asn
625 630 635
<210>175
<211>661
<212>PRT
<213>人
<400>175
Met Asp Leu Gln Gln Ser Thr Thr Ile Thr Ser Leu Glu Lys Trp Cys
1 5 10 15
Leu Asp Glu Ser Leu Ser Gly Cys Arg Arg His Tyr Ser Val Lys Lys
20 25 30
Lys Leu Lys Leu Ile Arg Val Leu Gly Leu Phe Met Gly Leu Val Ala
35 40 45
Ile Ser Thr Val Ser Phe Ser Ile Ser Ala Phe Ser Glu Thr Asp Thr
50 55 60
Gln Ser Thr Gly Glu Ala Ser Val Val Ser Gly Pro Arg Val Ala Gln
65 70 75 80
Gly Tyr His Gln Arg Thr Leu Leu Asp Leu Asn Asp Lys Ile Leu Asp
85 90 95
Tyr Thr Pro Gln Pro Pro Leu Ser Lys Glu Gly Glu Ser Glu Asn Ser
100 105 110
Thr Asp His Ala Gln Gly Asp Tyr Pro Lys Asp Ile Phe Ser Leu Glu
115 120 125
Glu Arg Arg Lys Gly Ala Ile Ile Leu His Val Ile Gly Met Ile Tyr
130 135 140
Met Phe Ile Ala Leu Ala Ile Val Cys Asp Glu Phe Phe Val Pro Ser
145 150 155 160
Leu Thr Val Ile Thr Glu Lys Leu Gly Ile Ser Asp Asp Val Ala Gly
165 170 175
Ala Thr Phe Met Ala Ala Gly Gly Ser Ala Pro Glu Leu Phe Thr Ser
180 185 190
Leu Ile Gly Val Phe Ile Ala His Ser Asn Val Gly Ile Gly Thr Ile
195 200 205
Val Gly Ser Ala Val Phe Asn Ile Leu Phe Val Ile Gly Met Cys Ala
210 215 220
Leu Phe Ser Arg Glu Ile Leu Asn Leu Thr Trp Trp Pro Leu Phe Arg
225 230 235 240
Asp Val Ser Phe Tyr Ile Val Asp Leu Ile Met Leu Ile Ile Phe Phe
245 250 255
Leu Asp Asn Val Ile Met Trp Trp Glu Ser Leu Leu Leu Leu Thr Ala
260 265 270
Tyr Phe Cys Tyr Val Val Phe Met Lys Phe Asn Val Gln Val Glu Lys
275 280 285
Trp Val Lys Gln Met Ile Asn Arg Asn Lys Val Val Lys Val Thr Ala
290 295 300
Pro Glu Ala Gln Ala Lys Pro Ser Ala Ala Arg Asp Lys Asp Glu Pro
305 310 315 320
Thr Leu Pro Ala Lys Pro Arg Leu Gln Arg Gly Gly Ser Ser Ala Ser
325 330 335
Leu His Asn Ser Leu Met Arg Asn Ser Ile Phe Gln Leu Met Ile His
340 345 350
Thr Leu Asp Pro Leu Ala Glu Glu Leu Gly Ser Tyr Gly Lys Leu Lys
355 360 365
Tyr Tyr Asp Thr Met Thr Glu Glu Gly Arg Phe Arg Glu Lys Ala Ser
370 375 380
Ile Leu His Lys Ile Ala Lys Lys Lys Cys His Val Asp Glu Asn Glu
385 390 395 400
Arg Gln Asn Gly Ala Ala Asn His Val Glu Lys Ile Glu Leu Pro Asn
405 410 415
Ser Thr Ser Thr Asp Val Glu Met Thr Pro Ser Ser Asp Ala Ser Glu
420 425 430
Pro Val Gln Asn Gly Asn Leu Ser His Asn Ile Glu Gly Ala Glu Ala
435 440 445
Gln Thr Ala Asp Glu Glu Glu Asp Gln Pro Leu Ser Leu Ala Trp Pro
450 455 460
Ser Glu Thr Arg Lys Gln Val Thr Phe Leu Ile Val Phe Pro Ile Val
465 470 475 480
Phe Pro Leu Trp Ile Thr Leu Pro Asp Val Arg Lys Pro Ser Ser Arg
485 490 495
Lys Phe Phe Pro Ile Thr Phe Phe Gly Ser Ile Thr Trp Ile Ala Val
500 505 510
Phe Ser Tyr Leu Met Val Trp Trp Ala His Gln Val Gly Glu Thr Ile
515 520 525
Gly Ile Ser Glu Glu Ile Met Gly Leu Thr Ile Leu Ala Ala Gly Thr
530 535 540
Ser Ile Pro Asp Leu Ile Thr Ser Val Ile Val Ala Arg Lys Gly Leu
545 550 555 560
Gly Asp Met Ala Val Ser Ser Ser Val Gly Ser Asn Ile Phe Asp Ile
565 570 575
Thr Val Gly Leu Pro Leu Pro Trp Leu Leu Tyr Thr Val Ile His Arg
580 585 590
Phe Gln Pro Val Ala Val Ser Ser Asn Gly Leu Phe Cys Ala Ile Val
595 600 605
Leu Leu Phe Ile Met Leu Leu Phe Val Ile Leu Ser Ile Ala Leu Cys
610 615 620
Lys Trp Arg Met Asn Lys Ile Leu Gly Phe Ile Met Phe Gly Leu Tyr
625 630 635 640
Phe Val Phe Leu Val Val Ser Val Leu Leu Glu Asp Arg Ile Leu Thr
645 650 655
Lys Pro Val Ser Ile
660
<210>176
<211>780
<212>PRT
<213>人
<400>176
Met Ala Ala Pro Gly Gly Arg Ser Glu Pro Pro Gln Leu Pro Glu Tyr
1 5 10 15
Ser Cys Ser Tyr Met Val Ser Arg Pro Val Tyr Ser Glu Leu Ala Phe
20 25 30
Gln Gln Gln His Glu Arg Arg Leu Gln Glu Arg Lys Thr Leu Arg Glu
35 40 45
Ser Leu Ala Lys Cys Cys Ser Cys Ser Arg Lys Arg Ala Phe Gly Val
50 55 60
Leu Lys Thr Leu Val Pro Ile Leu Glu Trp Leu Pro Lys Tyr Arg Val
65 70 75 80
Lys Glu Trp Leu Leu Ser Asp Val Ile Ser Gly Val Ser Thr Gly Leu
85 90 95
Val Ala Thr Leu Gln Gly Met Ala Tyr Ala Leu Leu Ala Ala Val Pro
100 105 110
Val Gly Tyr Gly Leu Tyr Ser Ala Phe Phe Pro Ile Leu Thr Tyr Phe
115 120 125
Ile Phe Gly Thr Ser Arg Hi s Ile Ser Val Gly Pro Phe Pro Val Val
130 135 140
Ser Leu Met Val Gly Ser Val Val Leu Ser Met Ala Pro Asp Glu His
145 150 155 160
Phe Leu Val Ser Ser Ser Asn Gly Thr Val Leu Asn Thr Thr Met Ile
165 170 175
Asp Thr Ala Ala Arg Asp Thr Ala Arg Val Leu Ile Ala Ser Ala Leu
180 185 190
Thr Leu Leu Val Gly Ile Ile Gln LeuIle Phe Gly Gly Leu Gln Ile
195 200 205
Gly Phe Ile Val Arg Tyr Leu Ala Asp Pro Leu Val Gly Gly Phe Thr
210 215 220
Thr Ala Ala Ala Phe Gln Val Leu Val Ser Gln Leu Lys Ile Val Leu
225 230 235 240
Asn Val Ser Thr Lys Asn Tyr Asn Gly Val Leu Ser Ile Ile Tyr Thr
245 250 255
Leu Val Glu Ile Phe Gln Asn Ile Gly Asp Thr Asn Leu Ala Asp Phe
260 265 270
Thr Ala Gly Leu Leu Thr Ile Val Val Cys Met Ala Val Lys Glu Leu
275 280 285
Asn Asp Arg Phe Arg His Lys Ile Pro Val Pro Ile Pro Ile Glu Val
290 295 300
Ile Val Thr Ile Ile Ala Thr Ala Ile Ser Tyr Gly Ala Asn Leu Glu
305 310 315 320
Lys Asn Tyr Asn Ala Gly Ile Val Lys Ser Ile Pro Arg Gly Phe Leu
325 330 335
Pro Pro Glu Leu Pro Pro Val Ser Leu Phe Ser Glu Met Leu Ala Ala
340 345 350
Ser Phe Ser Ile Ala Val Val Ala Tyr Ala Ile Ala Val Ser Val Gly
355 360 365
Lys Val Tyr Ala Thr Lys Tyr Asp Tyr Thr Ile Asp Gly Asn Gln Glu
370 375 380
Phe Ile Ala Phe Gly Ile Ser Asn Ile Phe Ser Gly Phe Phe Ser Cys
385 390 395 400
Phe Val Ala Thr Thr Ala Leu Ser Arg Thr Ala Val Gln Glu Ser Thr
405 410 415
Gly Gly Lys Thr Gln Val Ala Gly Ile Ile Ser Ala Ala Ile Val Met
420 425 430
Ile Ala Ile Leu Ala Leu Gly Lys Leu Leu Glu Pro Leu Gln Lys Ser
435 440 445
Val Leu Ala Ala Val Val Ile Ala Asn Leu Lys Gly Met Phe Met Gln
450 455 460
Leu Cys Asp Ile Pro Arg Leu Trp Arg Gln Asn Lys Ile Asp Ala Val
465 470 475 480
Ile Trp Val Phe Thr Cys Ile Val Ser Ile Ile Leu Gly Leu Asp Leu
485 490 495
Gly Leu Leu Ala Gly Leu Ile Phe Gly Leu Leu Thr Val Val Leu Arg
500 505 510
Val Gln Phe Pro Ser Trp Asn Gly Leu Gly Ser Ile Pro Ser Thr Asp
515 520 525
Ile Tyr Lys Ser Thr Lys Asn Tyr Lys Asn Ile Glu Glu Pro Gln Gly
530 535 540
Val Lys Ile Leu Arg Phe Ser Ser Pro Ile Phe Tyr Gly Asn Val Asp
545 550 555 560
Gly Phe Lys Lys Cys Ile Lys Ser Thr Val Gly Phe Asp Ala Ile Arg
565 570 575
Val Tyr Asn Lys Arg Leu Lys Ala Leu Arg Lys Ile Gln Lys Leu Ile
580 585 590
Lys Ser Gly Gln Leu Arg Ala Thr Lys Asn Gly Ile Ile Ser Asp Ala
595 600 605
Val Ser Thr Asn Asn Ala Phe Glu Pro Asp Glu Asp Ile Glu Asp Leu
610 615 620
Glu Glu Leu Asp Ile Pro Thr Lys Glu Ile Glu Ile Gln Val Asp Trp
625 630 635 640
Asn Ser Glu Leu Pro Val Lys Val Asn Val Pro Lys Val Pro Ile His
645 650 655
Ser Leu Val Leu Asp Cys Gly Ala Ile Ser Phe Leu Asp Val Val Gly
660 665 670
Val Arg Ser Leu Arg Val Ile Val Lys Glu Phe Gln Arg Ile Asp Val
675 680 685
Asn Val Tyr Phe Ala Ser Leu Gln Asp Tyr Val Ile Glu Lys Leu Glu
690 695 700
Gln Cys Gly Phe Phe Asp Asp Asn Ile Arg Lys Asp Thr Phe Phe Leu
705 710 715 720
Thr Val His Asp Ala Ile Leu Tyr Leu Gln Asn Gln Val Lys Ser Gln
725 730 735
Glu Gly Gln Gly Ser Ile Leu Glu Thr Ile Thr Leu Ile Gln Asp Cys
740 745 750
Lys Asp Thr Leu Glu Leu Ile Glu Thr Glu Leu Thr Glu Glu Glu Leu
755 760 765
Asp Val Gln Asp Glu Ala Met Arg Thr Leu Ala Ser
770 775 780
<910>177
<211>670
<212>PRT
<213>人
<400>177
Met Gly Glu Thr Glu Lys Arg Ile Glu Thr His Arg Ile Arg Cys Leu
1 5 10 15
Ser Lys Leu Lys Met Phe Leu Leu Ala Ile Thr Cys Ala Phe Val Ser
20 25 30
Lys Thr Leu Ser Gly Ser Tyr Met Asn Ser Met Leu Thr Gln Ile Glu
35 40 45
Arg Gln Phe Asn Ile Pro Thr Ser Leu Val Gly Phe Ile Asn Gly Ser
50 55 60
Phe Glu Ile Gly Asn Leu Leu Leu Ile Ile Phe Val Ser Tyr Phe Gly
65 70 75 80
Thr Lys Leu His Arg Pro Ile Met Ile Gly Ile Gly Cys Val Val Met
85 90 95
Gly Leu Gly Cys Phe Leu Lys Ser Leu Pro His Phe Leu Met Asn Gln
100 105 110
Tyr Glu Tyr Glu Ser Thr Val Ser Val Ser Gly Asn Leu Ser Ser Asn
115 120 125
Ser Phe Leu Cys Met Glu Asn Gly Thr Gln Ile Leu Arg Pro Thr Gln
130 135 140
Asp Pro Ser Glu Cys Thr Lys Glu Val Lys Ser Leu Met Trp Val Tyr
145 150 155 160
Val Leu Val Gly Asn Ile Val Arg Gly Met Gly Glu Thr Pro Ile Leu
165 170 175
Pro Leu Gly Ile Ser Tyr Ile Glu Asp Phe Ala Lys Phe Glu Asn Ser
180 185 190
Pro Leu Tyr Ile Gly Leu Val Glu Thr Gly Ala Ile Ile Gly Pro Leu
195 200 205
Ile Gly Leu Leu Leu Ala Ser Phe Cys Ala Asn Val Tyr Val Asp Thr
210 215 220
Gly Phe Val Asn Thr Asp Asp Leu Ile Ile Thr Pro Thr Asp Thr Arg
225 230 235 240
Trp Val Gly Ala Trp Trp Phe Gly Phe Leu Ile Cys Ala Gly Val Asn
245 250 255
Val Leu Thr Ala Ile Pro Phe Phe Phe Leu Pro Asn Thr Leu Pro Lys
260 265 270
Glu Gly Leu Glu Thr Asn Ala Asp Ile Ile Lys Asn Glu Asn Glu Asp
275 280 285
Lys Gln Lys Glu Glu Val Lys Lys Glu Lys Tyr Gly Ile Thr Lys Asp
290 295 300
Phe Leu Pro Phe Met Lys Ser Leu Ser Cys Asn Pro Ile Tyr Met Leu
305 310 315 320
Phe Ile Leu Val Ser Val Ile Gln Phe Asn Ala Phe Val Asn Met Ile
325 330 335
Ser Phe Met Pro Lys Tyr Leu Glu Gln Gln Tyr Gly Ile Ser Ser Ser
340 345 350
Asp Ala Ile Phe Leu Met Gly Ile Tyr Asn Leu Pro Pro Ile Cys Ile
355 360 365
Gly Tyr Ile Ile Gly Gly Leu Ile Met Lys Lys Phe Lys Ile Thr Val
370 375 380
Lys Gln Ala Ala His Ile Gly Cys Trp Leu Ser Leu Leu Glu Tyr Leu
385 390 395 400
Leu Tyr Phe Leu Ser Phe Leu Met Thr Cys Glu Asn Ser Ser Val Val
405 410 415
Gly Ile Asn Thr Ser Tyr Glu Gly Ile Pro Gln Asp Leu Tyr Val Glu
420 425 430
Asn Asp Ile Phe Ala Asp Cys Asn Val Asp Cys Asn Cys Pro Ser Lys
435 440 445
Ile Trp Asp Pro Val Cys Gly Asn Asn Gly Leu Ser Tyr Leu Ser Ala
450 455 460
Cys Leu Ala Gly Cys Glu Thr Ser Ile Gly Thr Gly Ile Asn Met Val
465 470 475 480
Phe Gln Asn Cys Ser Cys Ile Gln Thr Ser Gly Asn Ser Ser Ala Val
485 490 495
Leu Gly Leu Cys Asp Lys Gly Pro Asp Cys Ser Leu Met Leu Gln Tyr
500 505 510
Phe Leu Ile Leu Ser Ala Met Ser Ser Phe Ile Tyr Ser Leu Ala Ala
515 520 525
Ile Pro Gly Tyr Met Val Leu Leu Arg Cys Met Lys Ser Glu Glu Lys
530 535 540
Ser Leu Gly Val Gly Leu His Thr Phe Cys Thr Arg Val Phe Ala Gly
545 550 555 560
Ile Pro Ala Pro Ile Tyr Phe Gly Ala Leu Met Asp Ser Thr Cys Leu
565 570 575
His Trp Gly Thr Leu Lys Cys Gly Glu Ser Gly Ala Cys Arg Ile Tyr
580 585 590
Asp Ser Thr Thr Phe Arg Tyr Ile Tyr Leu Gly Leu Pro Ala Ala Leu
595 600 605
Arg Gly Ser Ser Phe Val Pro Ala Leu Ile Ile Leu Ile Leu Leu Arg
610 615 620
Lys Cys His Leu Pro Gly Glu Asn Ala Ser Ser Gly Thr Glu Leu Ile
625 630 635 640
Glu Thr Lys Val Lys Gly Lys Glu Asn Glu Cys Lys Asp Ile Tyr Gln
645 650 655
Lys Ser Thr Val Leu Lys Asp Asp Glu Leu Lys Thr Lys Leu
660 665 670
<210>178
<211>284
<212>PRT
<213>人
<400>178
Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu
1 5 10 15
Asn Ala Ile Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Gln Ala
20 25 30
Glu Asp Arg Cys Lys Gln Leu Glu Glu Glu Gln Gln Ala Leu Gln Lys
35 40 45
Lys Leu Lys Gly Thr Glu Asp Glu Val Glu Lys Tyr Ser Glu Ser Val
50 55 60
Lys Glu Ala Gln Glu Lys Leu Glu Gln Ala Glu Lys Lys Ala Thr Asp
65 70 75 80
Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu
85 90 95
Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys
100 105 110
Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys
115 120 125
Val Ile Glu Asn Arg Ala Met Lys Asp Glu Glu Lys Met Glu Leu Gln
130 135 140
Glu Met Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ser Asp Arg
145 150 155 160
Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Leu Glu Gly Glu Leu
165 170 175
Glu Arg Ser Glu Glu Arg Ala Glu Val Ala Glu Ser Lys Cys Gly Asp
180 185 190
Leu Glu Glu Glu Leu Lys Ile Val Thr Asn Asn Leu Lys Ser Leu Glu
195 200 205
Ala Gln Ala Asp Lys Tyr Ser Thr Lys Glu Asp Lys Tyr Glu Glu Glu
210 215 220
Ile Lys Leu Leu Glu Glu Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu
225 230 235 240
Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu
245 250 255
Glu Asp Glu Val Tyr Ala Gln Lys Met Lys Tyr Lys Ala Ile Ser Glu
260 265 270
Glu Leu Asp Asn Ala Leu Asn Asp Ile Thr Ser Leu
275 280
<210>179
<211>329
<212>PRT
<213>人
<400>179
Met Thr Gly Asn Ala Gly Glu Trp Cys Leu Met Glu Ser Asp Pro Gly
1 5 10 15
Val Phe Thr Glu Leu Ile Lys Gly Phe Gly Cys Arg Gly Ala Gln Val
20 25 30
Glu Glu Ile Trp Ser Leu Glu Pro Glu Asn Phe Glu Lys Leu Lys Pro
35 40 45
Val His Gly Leu Ile Phe Leu Phe Lys Trp Gln Pro Gly Glu Glu Pro
50 55 60
Ala Gly Ser Val Val Gln Asp Ser Arg Leu Asp Thr Ile Phe Phe Ala
65 70 75 80
Lys Gln Val Ile Asn Asn Ala Cys Ala Thr Gln Ala Ile Val Ser Val
85 90 95
Leu Leu Asn Cys Thr His Gln Asp Val His Leu Gly Glu Thr Leu Ser
100 105 110
Glu Phe Lys Glu Phe Ser Gln Ser Phe Asp Ala Ala Met Lys Gly Leu
115 120 125
Ala Leu Ser Asn Ser Asp Val Ile Arg Gln Val His Asn Ser Phe Ala
130 135 140
Arg Gln Gln Met Phe Glu Phe Asp Thr Lys Thr Ser Ala Lys Glu Glu
145 150 155 160
Asp Ala Phe His Phe Val Ser Tyr Val Pro Val Asn Gly Arg Leu Tyr
165 170 175
Glu Leu Asp Gly Leu Arg Glu Gly Pro Ile Asp Leu Gly Ala Gys Asn
180 185 190
Gln Asp Asp Trp Phe Ser Ala Val Arg Pro Val Ile Glu Lys Arg Ile
195 200 205
Gln Lys Tyr Ser Glu Gly Glu Ile Arg Phe Asn Leu Met Ala Ile Val
210 215 220
Ser Asp Arg Lys Met Ile Tyr Glu Gln Lys Ile Ala Glu Leu Gln Arg
225 230 235 240
Gln Leu Ala Glu Glu Glu Pro Met Asp Thr Asp Gln Gly Asn Ser Met
245 250 255
Leu Ser Ala Ile Gln Ser Glu Val Ala Lys Asn Gln Met Leu Ile Glu
260 265 270
Glu Glu Val Gln Lys Leu Lys Arg Tyr Lys Ile Glu Asn Ile Arg Arg
275 280 285
Lys His Asn Tyr Leu Pro Phe Ile Met Glu Leu Leu Lys Thr Leu Ala
290 295 300
Glu His Gln Gln Leu Ile Pro Leu Val Glu Lys Ala Lys Glu Lys Gln
305 310 315 320
Asn Ala Lys Lys Ala Gln Glu Thr Lys
325
<210>180
<211>54l
<212>PRT
<213>人
<400>180
Met Lys Ser Tyr Thr Pro Tyr Phe Ile Leu Leu Trp Ser Ala Val Gly
1 5 10 15
Ile Ala Lys Ala Ala Lys Ile Ile Ile Val Pro Pro Ile Met Phe Glu
20 25 30
Ser His Met Tyr Ile Phe Lys Thr Leu Ala Ser Ala Leu His Glu Arg
35 40 45
Gly His His Thr Val Phe Leu Leu Ser Glu Gly Arg Asp Ile Ala Pro
50 55 60
Ser Asn His Tyr Ser Leu Gln Arg Tyr Pro Gly Ile Phe Asn Ser Thr
65 70 75 80
Thr Ser Asp Ala Phe Leu Gln Ser Lys Met Arg Asn Ile Phe Ser Gly
85 90 95
Arg Leu Thr Ala Ile Glu Leu Phe Asp Ile Leu Asp His Tyr Thr Lys
100 105 110
Asn Cys Asp Leu Met Val Gly Asn His Ala Leu Ile Gln Gly Leu Lys
115 120 125
Lys Glu Lys Phe Asp Leu Leu Leu Val Asp Pro Asn Asp Met Cys Gly
130 135 140
Phe Val Ile Ala His Leu Leu Gly Val Lys Tyr Ala Val Phe Ser Thr
145 150 155 160
Gly Leu Trp Tyr Pro Ala Glu Val Gly Ala Pro Ala Pro Leu Ala Tyr
165 170 175
Val Pro Glu Phe Asn Ser Leu Leu Thr Asp Arg Met Asn Leu Leu Gln
180 185 190
Arg Met Lys Asn Thr Gly Val Tyr Leu Ile Ser Arg Leu Gly Val Ser
195 200 205
Phe Leu Val Leu Pro Lys Tyr Glu Arg Ile Met Gln Lys Tyr Asn Leu
210 215 220
Leu Pro Glu Lys Ser Met Tyr Asp Leu Val His Gly Ser Ser Leu Trp
225 230 235 240
Met Leu Cys Thr Asp Val Ala Leu Glu Phe Pro Arg Pro Thr Leu Pro
245 250 255
Asn Val Val Tyr Val Gly Gly Ile Leu Thr Lys Pro Ala Ser Pro Leu
260 265 270
Pro Glu Asp Leu Gln Arg Trp Val Asn Gly Ala Asn Glu His Gly Phe
275 280 285
Val Leu Val Ser Phe Gly Ala Gly Val Lys Tyr Leu Ser Glu Asp Ile
290 295 300
Ala Asn Lys Leu Ala Gly Ala Leu Gly Arg Leu Pro Gln Lys Val Ile
305 310 315 320
Trp Arg Phe Ser Gly Pro Lys Pro Lys Asn Leu Gly Asn Asn Thr Lys
325 330 335
Leu Ile Glu Trp Leu Pro Gln Asn Asp Leu Leu Gly His Ser Lys Ile
340 345 350
Lys Ala Phe Leu Ser His Gly Gly Leu Asn Ser Ile Phe Glu Thr Met
355 360 365
Tyr His Gly Val Pro Val Val Gly Ile Pro Leu Phe Gly Asp His Tyr
370 375 380
Asp Thr Met Thr Arg Val Gln Ala Lys Gly Met Gly Ile Leu Leu Glu
385 390 395 400
Trp Lys Thr Val Thr Glu Lys Glu Leu Tyr Glu Ala Leu Val Lys Val
405 410 415
Ile Asn Asn Pro Ser Tyr Arg Gln Arg Ala Gln Lys Leu Ser Glu Ile
420 425 430
His Lys Asp Gln Pro Gly His Pro Val Asn Arg Thr Ile Tyr Trp Ile
435 440 445
Asp Tyr Ile Ile Arg His Asn Gly Ala His His Leu Arg Ala Ala Val
450 455 460
His Gln Ile Ser Phe Cys Gln Tyr Phe Leu Leu Asp Ile Ala Phe Val
465 470 475 480
Leu Leu Leu Gly Ala Ala Leu Leu Tyr Phe Leu Leu Ser Trp Val Thr
485 490 495
Lys Phe Ile Tyr Arg Lys Ile Lys Ser Leu Trp Ser Arg Asn Lys His
500 505 510
Ser Thr Val Asn Gly His Tyr His Asn Gly Ile Leu Asn Gly Lys Tyr
515 520 525
Lys Arg Asn Gly His Ile Lys His Glu Lys Lys Val Lys
530 535 540
<210>181
<211>457
<212>PRT
<213>人
<400>181
Met Ser Gln Gly Ser Val Thr Phe Arg Asp Val Ala Ile Asp Phe Ser
5 10 15
Gln Glu Glu Trp Lys Trp Leu Gln Pro Ala Gln Arg Asp Leu Tyr Arg
20 25 30
Cys Val Met Leu Glu Asn Tyr Gly His Leu Val Ser Leu Gly Leu Ser
35 40 45
Ile Ser Lys Pro Asp Val Val Ser Leu Leu Glu Gln Gly Lys Glu Pro
50 55 60
Trp Leu Gly Lys Arg Glu Val Lys Arg Asp Leu Phe Ser Val Ser Glu
65 70 75 80
Ser Ser Gly Glu Ile Lys Asp Phe Ser Pro Lys Asn Val Ile Tyr Asp
85 90 95
Asp Ser Ser Gln Tyr Leu Ile Met Glu Arg Ile Leu Ser Gln Gly Pro
100 105 110
Val Tyr Ser Ser Phe Lys Gly Gly Trp Lys Cys Lys Asp His Thr Glu
115 120 125
Met Leu Gln Glu Asn Gln Gly Cys Ile Arg Lys Val Thr Val Ser His
130 135 140
Gln Glu Ala Leu Ala Gln His Met Asn Ile Ser Thr Val Glu Arg Pro
145 150 155 160
Tyr Gly Cys His Glu Cys Gly Lys Thr Phe Gly Arg Arg Phe Ser Leu
165 170 175
Val Leu His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Ala Cys Lys
180 185 190
Glu Cys Gly Lys Thr Phe Ser Gln Ile Ser Asn Leu Val Lys His Gln
195 200 205
Met Ile His Thr Gly Lys Lys Pro His Glu Cys Lys Asp Cys Asn Lys
210 215 220
Thr Phe Ser Tyr Leu Ser Phe Leu Ile Glu His Gln Arg Thr His Thr
225 230 235 240
Gly Glu Lys Pro Tyr Glu Cys Thr Glu Cys Gly Lys Ala Phe Ser Arg
245 250 255
Ala Ser Asn Leu Thr Arg His Gln Arg Ile His Ile Gly Lys Lys Gln
260 265 270
Tyr Ile Cys Arg Lys Cys Gly Lys Ala Phe Ser Ser Gly Ser Glu Leu
275 280 285
Ile Arg His Gln Ile Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Ile
290 295 300
Glu Cys Gly Lys Ala Phe Arg Arg Phe Ser His Leu Thr Arg His Gln
305 310 315 320
Ser Ile His Thr Thr Lys Thr Pro Tyr Glu Cys Asn Glu Cys Arg Lys
325 330 335
Ala Leu Arg Cys His Ser Phe Leu Ile Lys His Gln Arg Ile His Ala
340 345 350
Gly Glu Lys Leu Tyr Glu Cys Asp Glu Cys Gly Lys Val Phe Thr Trp
355 360 365
His Ala Ser Leu Ile Gln His Thr Lys Ser His Thr Gly Glu Lys Pro
370 375 380
Tyr Ala Cys Ala Glu Cys Asp Lys Ala Phe Ser Arg Ser Phe Ser Leu
385 390 395 400
Ile Leu His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Val Cys Lys
405 410 415
Val Cys Asn Lys Ser Phe Ser Trp Ser Ser Asn Leu Ala Lys His Gln
420 425 430
Arg Thr His Thr Leu Asp Asn Pro Tyr Glu Tyr Glu Asn Ser Phe Asn
435 440 445
Tyr His Ser Phe Leu Thr Glu His Gln
450 455
<210>182
<211>653
<212>PRT
<213>人
<400>182
Met Ala Ser Arg Leu Pro Thr Ala Trp Ser Cys Glu Pro Val Thr Phe
1 5 10 15
Glu Asp Val Thr Leu Gly Phe Thr Pro Glu Glu Trp Gly Leu Leu Asp
20 25 30
Leu Lys Gln Lys Ser Leu Tyr Arg Glu Val Met Leu Glu Asn Tyr Arg
35 40 45
Asn Leu Val Ser Val Glu His Gln Leu Ser Lys Pro Asp Val Val Ser
50 55 60
Gln Leu Glu Glu Ala Glu Asp Phe Trp Pro Val Glu Arg Gly Ile Pro
65 70 75 80
Gln Asp Thr Ile Pro Glu Tyr Pro Glu Leu Gln Leu Asp Pro Lys Leu
85 90 95
Asp Pro Leu Pro Ala Glu Ser Pro Leu Met Asn Ile Glu Val Val Glu
100 105 110
Val Leu Thr Leu Asn Gln Glu Val Ala Gly Pro Arg Asn Ala Gln Ile
115 120 125
Gln Ala Leu Tyr Ala Glu Asp Gly Ser Leu Ser Ala Asp Ala Pro Ser
130 135 140
Glu Gln Ile Gln Gln Gln Gly Lys His Pro Gly Asp Pro Glu Ala Ala
145 150 155 160
Arg Gln Arg Phe Arg Gln Phe Arg Tyr Lys Asp Met Thr Gly Pro Arg
165 170 175
Glu Ala Leu Asp Gln Leu Arg Glu Leu Cys His Gln Trp Leu Gln Pro
180 185 190
Lys Ala Arg Ser Lys Glu Gln Ile Leu Glu Leu Leu Val Leu Glu Gln
195 200 205
Phe Leu Gly Ala Leu Pro Val Lys Leu Arg Thr Trp Val Glu Ser Gln
210 215 220
His Pro Glu Asn Cys Gln Glu Val Val Ala Leu Val Glu Gly Val Thr
225 230 235 240
Trp Met Ser Glu Glu Glu Val Leu Pro Ala Gly Gln Pro Ala Glu Gly
245 250 255
Thr Thr Cys Cys Leu Glu Val Thr Ala Gln Gln Glu Glu Lys Gln Glu
260 265 270
Asp Ala Ala Ile Cys Pro Val Thr Val Leu Pro Glu Glu Pro Val Thr
275 280 285
Phe Gln Asp Val Ala Val Asp Phe Ser Arg Glu Glu Trp Gly Leu Leu
290 295 300
Gly Pro Thr Gln Arg Thr Glu Tyr Arg Asp Val Met Leu Glu Thr Phe
305 310 315 320
Gly His Leu Val Ser Val Gly Trp Glu Thr Thr Leu Glu Asn Lys Glu
325 330 335
Leu Ala Pro Asn Ser Asp Ile Pro Glu Glu Glu Pro Ala Pro Ser Leu
340 345 350
Lys Val Gln Glu Ser Ser Arg Asp Cys Ala Leu Ser Ser Thr Leu Glu
355 360 365
Asp Thr Leu Gln Gly Gly Val Gln Glu Val Gln Asp Thr Val Leu Lys
370 375 380
Gln Met Glu Ser Ala Gln Glu Lys Asp Leu Pro Gln Lys Lys His Phe
385 390 395 400
Asp Asn Arg Glu Ser Gln Ala Asn Ser Gly Ala Leu Asp Thr Asn Gln
405 410 415
Val Ser Leu Gln Lys Ile Asp Asn Pro Glu Ser Gln Ala Asn Ser Gly
420 425 430
Ala Leu Asp Thr Asn Gln Val Leu Leu His Lys Ile Pro Pro Arg Lys
435 440 445
Arg Leu Arg Lys Arg Asp Ser Gln Val Lys Ser Met Lys His Asn Ser
450 455 460
Arg Val Lys Ile His Gln Lys Ser Cys Glu Arg Gln Lys Ala Lys Glu
465 470 475 480
Gly Asn Gly Cys Arg Lys Thr Phe Ser Arg Ser Thr Lys Gln Ile Thr
485 490 495
Phe Ile Arg Ile His Lys Gly Ser Gln Val Cys Arg Cys Ser Glu Cys
500 505 510
Gly Lys Ile Phe Arg Asn Pro Arg Tyr Phe Ser Val His Lys Lys Ile
515 520 525
His Thr Gly Glu Arg Pro Tyr Val Cys Gln Asp Cys Gly Lys Gly Phe
530 535 540
Val Gln Ser Ser Ser Leu Thr Gln His Gln Arg Val His Ser Gly Glu
545 550 555 560
Arg Pro Phe Glu Cys Gln Glu Cys Gly Arg Thr Phe Asn Asp Arg Ser
565 570 575
Ala Ile Ser Gln His Leu Arg Thr His Thr Gly Ala Lys Pro Tyr Lys
580 585 590
Cys Gln Asp Cys Gly Lys Ala Phe Arg Gln Ser Ser His Leu Ile Arg
595 600 605
His Gln Arg Thr His Thr Gly Glu Arg Pro Tyr Ala Cys Asn Lys Cys
610 615 620
Gly Lys Ala Phe Thr Gln Ser Ser His Leu Ile Gly His Gln Arg Thr
625 630 635 640
His Asn Arg Thr Lys Arg Lys Lys Lys Gln Pro Thr Ser
645 650
<210>183
<211>715
<212>PRT
<213>人
<400>183
Met Glu Thr Leu Glu Ser Glu Leu Thr Cys Pro Ile Cys Leu Glu Leu
1 5 10 15
Phe Glu Asp Pro Leu Leu Leu Pro Cys Ala His Ser Leu Cys Phe Ser
20 25 30
Cys Ala His Arg Ile Leu Val Ser Ser Cys Ser Ser Gly Glu Ser Ile
25 40 45
Glu Pro Ile Thr Ala Phe Gln Cys Pro Thr Cys Arg Tyr Val Ile Ser
50 55 60
Leu Asn His Arg Gly Leu Asp Gly Leu Lys Arg Asn Val Thr Leu Gln
65 70 75 80
Asn Ile Ile Asp Arg Phe Gln Lys Ala Ser Val Ser Gly Pro Asn Ser
85 90 95
Pro Ser Glu Ser Arg Arg Glu Arg Thr Tyr Arg Pro Thr Thr Ala Met
100 105 110
Ser Ser Glu Arg Ile Ala Cys Gln Phe Cys Glu Gln Asp Pro Pro Arg
115 120 125
Asp Ala Val Lys Thr Cys Ile Thr Cys Glu Val Ser Tyr Cys Asp Arg
130 135 140
Cys Leu Arg Ala Thr His Pro Asn Lys Lys Pro Phe Thr Ser His Arg
145 150 155 160
Leu Val Glu Pro Val Pro Asp Thr His Leu Arg Gly Ile Thr Cys Leu
165 170 175
Asp His Glu Asn Glu Lys Val Asn Met Tyr Cys Val Ser Asp Asp Gln
180 185 190
Leu Ile Cys Ala Leu Cys Lys Leu Val Gly Arg His Arg Asp Hi s Gln
195 200 205
Val Ala Ser Leu Asn Asp Arg Phe Glu Lys Leu Lys Gln Thr Leu Glu
210 215 220
Met Asn Leu Thr Asn Leu Val Lys Arg Asn Ser Glu Leu Glu Asn Gln
225 230 235 240
Met Ala Lys Leu Ile Gln Ile Cys Gln Gln Val Glu Val Asn Thr Ala
245 250 255
Met His Glu Ala Lys Leu Met Glu Glu Cys Asp Glu Leu Val Glu Ile
260 265 270
Ile Gln Gln Arg Lys Gln Met Ile Ala Val Lys Ile Lys Glu Thr Lys
275 280 285
Val Met Lys Leu Arg Lys Leu Ala Gln Gln Val Ala Asn Cys Arg Gln
290 295 300
Cys Leu Glu Arg Ser Thr Val Leu Ile Asn Gln Ala Glu His Ile Leu
305 310 315 320
Lys Glu Asn Asp Gln Ala Arg Phe Leu Gln Ser Ala Lys Asn Ile Ala
325 330 335
Glu Arg Val Ala Met Ala Thr Ala Ser Ser Gln Val Leu Ile Pro Asp
340 345 350
lle Asn Phe Asn Asp Ala Phe Glu Asn Phe Ala Leu Asp Phe Ser Arg
355 360 365
Glu Lys Lys Leu Leu Glu Gly Leu Asp Tyr Leu Thr Ala Pro Asn Pro
370 375 380
Pro Ser Ile Arg Glu Glu Leu Cys Thr Ala Ser His Asp Thr Ile Thr
385 390 395 400
Val His Trp Ile Ser Asp Asp Glu Phe Ser Ile Ser Ser Tyr Glu Leu
405 410 415
Gln Tyr Thr Ile Phe Thr Gly Gln Ala Asn Phe Ile Ser Lys Ser Trp
420 425 430
Cys Ser Trp Gly Leu Trp Pro Glu Ile Arg Lys Cys Lys Glu Ala Val
435 440 445
Ser Cys Ser Arg Leu Ala Gly Ala Pro Arg Gly Leu Tyr Asn Ser Val
450 455 460
Asp Ser Trp Met Ile Val Pro Asn Ile Lys Gln Asn His Tyr Thr Val
465 470 475 480
His Gly Leu Gln Ser Gly Thr Arg Tyr Ile Phe Ile Val Lys Ala Ile
485 490 495
Asn Gln Ala Gly Ser Arg Asn Ser Glu Pro Thr Arg Leu Lys Thr Asn
500 505 510
Ser Gln Pro Phe Lys Leu Asp Pro Lys Met Thr His Lys Lys Leu Lys
515 520 525
Ile Ser Asn Asp Gly Leu Gln Met Glu Lys Asp Glu Ser Ser Leu Lys
530 535 540
Lys Ser His Thr Pro Glu Arg Phe Ser Gly Thr Gly Cys Tyr Gly Ala
545 550 555 560
Ala Gly Asn Ile Phe Ile Asp Ser Gly Cys His Tyr Trp Glu Val Val
565 570 575
Met Gly Ser Ser Thr Trp Tyr Ala Ile Gly Ile Ala Tyr Lys Ser Ala
580 585 590
Pro Lys Asn Glu Trp Ile Gly Lys Asn Ala Ser Ser Trp Val Phe Ser
595 600 605
Arg Cys Asn Ser Asn Phe Val Val Arg His Asn Asn Lys Glu Met Leu
610 615 620
Val Asp Val Pro Pro His Leu Lys Arg Leu Gly Val Leu Leu Asp Tyr
625 630 635 640
Asp Asn Asn Met Leu Ser Phe Tyr Asp Pro Ala Asn Ser Leu His Leu
645 650 655
His Thr Phe Asp Val Thr Phe Ile Leu Pro Val Cys Pro Thr Phe Thr
660 665 670
Ile Trp Asn Lys Ser Leu Met Ile Leu Ser Gly Leu Pro Ala Pro Asp
675 680 685
Phe Ile Asp Tyr Pro Glu Arg Gln Glu Cys Asn Cys Arg Pro Gln Glu
690 695 700
Ser Pro Tyr Val Ser Gly Met Lys Thr Cys His
705 710 715
<210>184
<211>1076
<212>PRT
<213>人
<400>184
Met Glu Pro Gly Ser Lys Ser Val Ser Arg Ser Asp Trp Gln Pro Glu
1 5 10 15
Pro His Gln Arg Pro Ile Thr Pro Leu Glu Pro Gly Pro Glu Lys Thr
20 25 30
Pro Ile Ala Gln Pro Glu Ser Lys Thr Leu Gln Gly Ser Asn Thr Gln
35 40 45
Gln Lys Pro Ala Ser Asn Gln Arg Pro Leu Thr Gln Gln Glu Thr Pro
50 55 60
Ala Gln His Asp Ala Glu Ser Gln Lys Glu Pro Arg Ala Gln Gln Lys
65 70 75 80
Ser Ala Ser Gln Glu Glu Phe Leu Ala Pro Gln Lys Pro Ala Pro Gln
85 90 95
Gln Ser Pro Tyr Ile Gln Arg Val Leu Leu Thr Gln Gln Glu Ala Ala
100 105 110
Ser Gln Gln Gly Pro Gly Leu Gly Lys Glu Ser Ile Thr Gln Gln Glu
115 120 125
Pro Ala Leu Arg Gln Arg His Val Ala Gln Pro Gly Pro Gly Pro Gly
130 135 140
Glu Pro Pro Pro Ala Gln Gln Glu Ala Glu Ser Thr Pro Ala Ala Gln
145 150 155 160
Ala Lys Pro Gly Ala Lys Arg Glu Pro Ser Ala Pro Thr Glu Ser Thr
165 170 175
Ser Gln Glu Thr Pro Glu Gln Ser Asp Lys Gln Thr Thr Pro Val Gln
180 185 190
Gly Ala Lys Ser Lys Gln Gly Ser Leu Thr Glu Leu Gly Phe Leu Thr
195 200 205
Lys Leu Gln Glu Leu Ser Ile Gln Arg Ser Ala Leu Glu Trp Lys Ala
210 215 220
Leu Ser Glu Trp Val Ala Asp Ser Glu Ser Glu Ser Asp Val Gly Ser
225 230 235 240
Ser Ser Asp Thr Asp Ser Pro Ala Thr Met Gly Gly Met Val Ala Gln
245 250 255
Gly Val Lys Leu Gly Phe Lys Gly Lys Ser Gly Tyr Lys Val Met Ser
260 265 270
Gly Tyr Ser Gly Thr Ser Pro His Glu Lys Thr Ser Ala Arg Asn His
275 280 285
Arg His Tyr Gln Asp Thr Ala Ser Arg Leu Ile His Asn Met Asp Leu
290 295 300
Arg Thr Met Thr Gln Ser Leu Val Thr Leu Ala Glu Asp Asn Ile Ala
305 310 315 320
Phe Phe Ser Ser Gln Gly Pro Gly Glu Thr Ala Gln Arg Leu Ser Gly
325 330 335
Val Phe Ala Gly Val Arg Glu Gln Ala Leu Gly Leu Glu Pro Ala Leu
340 345 350
Gly Arg Leu Leu Gly Val Ala His Leu Phe Asp Leu Asp Pro Glu Thr
355 360 365
Pro Ala Asn Gly Tyr Arg Ser Leu Val His Thr Ala Arg Cys Cys Leu
370 375 380
Ala His Leu Leu His Lys Ser Arg Tyr Val Ala Ser Asn Arg Arg Ser
385 390 395 400
Ile Phe Phe Arg Thr Ser His Asn Leu Ala Glu Leu Glu Ala Tyr Leu
405 410 415
Ala Ala Leu Thr Gln Leu Arg Ala Leu Val Tyr Tyr Ala Gln Arg Leu
420 425 430
Leu Val Thr Asn Arg Pro Gly Val Leu Phe Phe Glu Gly Asp Glu Gly
435 440 445
Leu Thr Ala Asp Phe Leu Arg Glu Tyr Val Thr Leu His Lys Gly Cys
450 455 460
Phe Tyr Gly Arg Cys Leu Gly Phe Gln Phe Thr Pro Ala Ile Arg Pro
465 470 475 480
Phe Leu Gln Thr Ile Ser Ile Gly Leu Val Ser Phe Gly Glu His Tyr
485 490 495
Lys Arg Asn Glu Thr Gly Leu Ser Val Ala Ala Ser Ser Leu Phe Thr
500 505 510
Ser Gly Arg Phe Ala Ile Asp Pro Glu Leu Arg Gly Ala Glu Phe Glu
515 520 525
Arg Ile Thr Gln Asn Leu Asp Val His Phe Trp Lys Ala Phe Trp Asn
530 535 540
Ile Thr Glu Met Glu Val Leu Ser Ser Leu Ala Asn Met Ala Ser Ala
545 550 555 560
Thr Val Arg Val Ser Arg Leu Leu Ser Leu Pro Pro Glu Ala Phe Glu
565 570 575
Met Pro Leu Thr Ala Asp Pro Thr Leu Thr Val Thr Ile Ser Pro Pro
580 585 590
Leu Ala His Thr Gly Pro Gly Pro Val Leu Val Arg Leu Ile Ser Tyr
595 600 605
Asp Leu Arg Glu Gly Gln Asp Ser Glu Glu Leu Ser Ser Leu Ile Lys
610 615 620
Ser Asn Gly Gln Arg Ser Leu Glu Leu Trp Pro Arg Pro Gln Gln Ala
625 630 635 640
Pro Arg Ser Arg Ser Leu Ile Val His Phe His Gly Gly Gly Phe Val
645 650 655
Ala Gln Thr Ser Arg Ser His Glu Pro Tyr Leu Lys Ser Trp Ala Gln
660 665 670
Glu Leu Gly Ala Pro Ile Ile Ser Ile Asp Tyr Ser Leu Ala Pro Glu
675 680 685
Ala Pro Phe Pro Arg Ala Leu Glu Glu Cys Phe Phe Ala Tyr Cys Trp
690 695 700
Ala Ile Lys His Cys Ala Leu Leu Gly Ser Thr Gly Glu Arg Ile Cys
705 710 715 720
Leu Ala Gly Asp Ser Ala Gly Gly Asn Leu Cys Phe Thr Val Ala Leu
725 730 735
Arg Ala Ala Ala Tyr Gly Val Arg Val Pro Asp Gly Ile Met Ala Ala
740 745 750
Tyr Pro Ala Thr Met Leu Gln Pro Ala Ala Ser Pro Ser Arg Leu Leu
755 760 765
Ser Leu Met Asp Pro Leu Leu Pro Leu Ser Val Leu Ser Lys Cys Val
770 775 780
Ser Ala Tyr Ala Gly Ala Lys Thr Glu Asp His Ser Asn Ser Asp Gln
785 790 795 800
Lys Ala Leu Gly Met Met Gly Leu Val Arg Arg Asp Thr Ala Leu Leu
805 810 815
Leu Arg Asp Phe Arg Leu Gly Ala Ser Ser Trp Leu Asn Ser Phe Leu
820 825 830
Glu Leu Ser Gly Arg Lys Ser Gln Lys Met Ser Glu Pro Ile Ala Glu
835 840 845
Pro Met Arg Arg Ser Val Ser Glu Ala Ala Leu Ala Gln Pro Gln Gly
850 855 860
Pro Leu Gly Thr Asp Ser Leu Lys Asn Leu Thr Leu Arg Asp Leu Ser
865 870 875 880
Leu Arg Gly Asn Ser Glu Thr Ser Ser Asp Thr Pro Glu Met Ser Leu
885 890 895
Ser Ala Glu Thr Leu Ser Pro Ser Thr Pro Ser Asp Val Asn Phe Leu
900 905 910
Leu Pro Pro Glu Asp Ala Gly Glu Glu Ala Glu Ala Lys Asn Glu Leu
915 920 925
Ser Pro Met Asp Arg Gly Leu Gly Val Arg Ala Ala Phe Pro Glu Gly
930 935 940
Phe His Pro Arg Arg Ser Ser Gln Gly Ala Thr Gln Met Pro Leu Tyr
945 950 955 960
Ser Ser Pro Ile Val Lys Asn Pro Phe Met Ser Pro Leu Leu Ala Pro
965 970 975
Asp Ser Met Leu Lys Ser Leu Pro Pro Val His Ile Val Ala Cys Ala
980 985 990
Leu Asp Pro Met Leu Asp Asp Ser Val Met Leu Ala Arg Arg Leu Arg
995 1000 1005
Asn Leu Gly Gln Pro Val Thr Leu Arg Val Val Glu Asp Leu Pro
1010 1015 1020
His Gly Phe Leu Thr Leu Ala Ala Leu Cys Arg Glu Thr Arg Gln
1025 1030 1035
Ala Ala Glu Leu Cys Val Glu Arg Ile Arg Leu Val Leu Thr Pro
1040 1045 1050
Pro Ala Gly Ala Gly Pro Ser Gly Glu Thr Gly Ala Ala Gly Val
1055 1060 1065
Asp Gly Gly Cys Gly Gly Arg His
1070 1075
<210>185
<211>1215
<212>PRT
<213>人
<400>185
Met Thr Ser Thr Gly Gln Asp Ser Thr Thr Thr Arg Gln Arg Arg Ser
1 5 10 15
Arg Gln Asn Pro Gln Ser Pro Pro Gln Asp Ser Ser Val Thr Ser Lys
20 25 30
Arg Asn Ile Lys Lys Gly Ala Val Pro Arg Ser Ile Pro Asn Leu Ala
35 40 45
Glu Val Lys Lys Lys Gly Lys Met Lys Lys Leu Gly Gln Ala Met Glu
50 55 60
Glu Asp Leu Ile Val Gly Leu Gln Gly Met Asp Leu Asn Leu Glu Ala
65 70 75 80
Glu Ala Leu Ala Gly Thr Gly Leu Val Leu Asp Glu Gln Leu Asn Glu
85 90 95
Phe His Cys Leu Trp Asp Asp Ser Phe Pro Glu Gly Pro Glu Arg Leu
100 105 110
His Ala Ile Lys Glu Gln Leu Ile Gln Glu Gly Leu Leu Asp Arg Cys
115 120 125
Val Ser Phe Gln Ala Arg Phe Ala Glu Lys Glu Glu Leu Met Leu Val
130 135 140
His Ser Leu Glu Tyr Ile Asp Leu Met Glu Thr Thr Gln Tyr Met Asn
145 150 155 160
Glu Gly Glu Leu Arg Val Leu Ala Asp Thr Tyr Asp Ser Val Tyr Leu
165 170 175
His Pro Asn Ser Tyr Ser Cys Ala Cys Leu Ala Ser Gly Ser Val Leu
180 185 190
Arg Leu Val Asp Ala Val Leu Gly Ala Glu Ile Arg Asn Gly Met Ala
195 200 205
Ile Ile Arg Pro Pro Gly His His Ala Gln His Ser Leu Met Asp Gly
210 215 220
Tyr Cys Met Phe Asn His Val Ala Val Ala Ala Arg Tyr Ala Gln Gln
225 230 235 240
Lys His Arg Ile Arg Arg Val Leu Ile Val Asp Trp Asp Val His His
245 250 255
Gly Gln Gly Thr Gln Phe Thr Phe Asp Gln Asp Pro Ser Val Leu Tyr
260 265 270
Phe Ser Ile His Arg Tyr Glu Gln Gly Arg Phe Trp Pro His Leu Lys
275 280 285
Ala Ser Asn Trp Ser Thr Thr Gly Phe Gly Gln Gly Gln Gly Tyr Thr
290 295 300
Ile Asn Val Pro Trp Asn Gln Val Gly Met Arg Asp Ala Asp Tyr Ile
305 310 315 320
Ala Ala Phe Leu His Val Leu Leu Pro Val Ala Leu Glu Phe Gln Pro
325 330 335
Gln Leu Val Leu Val Ala Ala Gly Phe Asp Ala Leu Gln Gly Asp Pro
340 345 350
Lys Gly Glu Met Ala Ala Thr Pro Ala Gly Phe Ala Gln Leu Thr His
355 360 365
Leu Leu Met Gly Leu Ala Gly Gly Lys Leu Ile Leu Ser Leu Glu Gly
370 375 380
Gly Tyr Asn Leu Arg Ala Leu Ala Glu Gly Val Ser Ala Ser Leu His
385 390 395 400
Thr Leu Leu Gly Asp Pro Cys Pro Met Leu Glu Ser Pro Gly Ala Pro
405 410 415
Cys Arg Ser Ala Gln Ala Ser Val Ser Cys Ala Leu Glu Ala Leu Glu
420 425 430
Pro Phe Trp Glu Val Leu Val Arg Ser Thr Glu Thr Val Glu Arg Asp
435 440 445
Asn Met Glu Glu Asp Asn Val Glu Glu Ser Glu Glu Glu Gly Pro Trp
450 455 460
Glu Pro Pro Val Leu Pro Ile Leu Thr Trp Pro Val Leu Gln Ser Arg
465 470 475 480
Thr Gly Leu Val Tyr Asp Gln Asn Met Met Asn His Cys Asn Leu Trp
485 490 495
Asp Ser His His Pro Glu Val Pro Gln Arg Ile Leu Arg Ile Met Cys
500 505 510
Arg Leu Glu Glu Leu Gly Leu Ala Gly Arg Cys Leu Thr Leu Thr Pro
515 520 525
Arg Pro Ala Thr Glu Ala Glu Leu Leu Thr Cys His Ser Ala Glu Tyr
530 535 540
Val Gly His Leu Arg Ala Thr Glu Lys Met Lys Thr Arg Glu Leu His
545 550 555 560
Arg Glu Ser Ser Asn Phe Asp Ser Ile Tyr Ile Cys Pro Ser Thr Phe
565 570 575
Ala Cys Ala Gln Leu Ala Thr Gly Ala Ala Cys Arg Leu Val Glu Ala
580 585 590
Val Leu Ser Gly Glu Val Leu Asn Gly Ala Ala Val Val Arg Pro Pro
595 600 605
Gly His His Ala Glu Gln Asp Ala Ala Cys Gly Phe Cys Phe Phe Asn
610 615 620
Ser Val Ala Val Ala Ala Arg His Ala Gln Thr Ile Ser Gly His Ala
625 630 635 640
Leu Arg Ile Leu Ile Val Asp Trp Asp Val His His Gly Asn Gly Thr
645 650 655
Gln His Met Phe Glu Asp Asp Pro Ser Val Leu Tyr Val Ser Leu His
660 665 670
Arg Tyr Asp His Gly Thr Phe Phe Pro Met Gly Asp Glu Gly Ala Ser
675 680 685
Ser Gln Ile Gly Arg Ala Ala Gly Thr Gly Phe Thr Val Asn Val Ala
690 695 700
Trp Asn Gly Pro Arg Met Gly Asp Ala Asp Tyr Leu Ala Ala Trp His
705 710 715 720
Arg Leu Val Leu Pro Ile Ala Tyr Glu Phe Asn Pro Glu Leu Val Leu
725 730 735
Val Ser Ala Gly Phe Asp Ala Ala Arg Gly Asp Pro Leu Gly Gly Cys
740 745 750
Gln Val Ser Pro Glu Gly Tyr Ala His Leu Thr His Leu Leu Met Gly
755 760 765
Leu Ala Ser Gly Arg Ile Ile Leu Ile Leu Glu Gly Gly Tyr Asn Leu
770 775 780
Thr Ser Ile Ser Glu Ser Met Ala Ala Cys Thr Arg Ser Leu Leu Gly
785 790 795 800
Asp Pro Pro Pro Leu Leu Thr Leu Pro Arg Pro Pro Leu Ser Gly Ala
805 810 815
Leu Ala Ser Ile Thr Glu Thr Ile Gln Val His Arg Arg Tyr Trp Arg
820 825 830
Ser Leu Arg Val Met Lys Val Glu Asp Arg Glu Gly Pro Ser Ser Ser
835 840 845
Lys Leu Val Thr Lys Lys Ala Pro Gln Pro Ala Lys Pro Arg Leu Ala
850 855 860
Glu Arg Met Thr Thr Arg Glu Lys Lys Val Leu Glu Ala Gly Met Gly
865 870 875 880
Lys Val Thr Ser Ala Ser Phe Gly Glu Glu Ser Thr Pro Gly Gln Thr
885 890 895
Asn Ser Glu Thr Ala Val Val Ala Leu Thr Gln Asp Gln Pro Ser Glu
900 905 910
Ala Ala Thr Gly Gly Ala Thr Leu Ala Gln Thr Ile Ser Glu Ala Ala
915 920 925
Ile Gly Gly Ala Met Leu Gly Gln Thr Thr Ser Glu Glu Ala Val Gly
930 935 940
Gly Ala Thr Pro Asp Gln Thr Thr Ser Glu Glu Thr Val Gly Gly Ala
945 950 955 960
Ile Leu Asp Gln Thr Thr Ser Glu Asp Ala Val Gly Gly Ala Thr Leu
965 970 975
Gly Gln Thr Thr Ser Glu Glu Ala Val Gly Gly Ala Thr Leu Ala Gln
980 985 990
Thr Ile Ser Glu Ala Ala Met Glu Gly Ala Thr Leu Asp Gln Thr Thr
995 1000 1005
Ser Glu Glu Ala Pro Gly Gly Thr Glu Leu Ile Gln Thr Pro Leu
1010 1015 1020
Ala Ser Ser Thr Asp His Gln Thr Pro Pro Thr Ser Pro Val Gln
1025 1030 1035
Gly Thr Thr Pro Gln Ile Ser Pro Ser Thr Leu Ile Gly Ser Leu
1040 1045 1050
Arg Thr Leu Glu Leu Gly Ser Glu Ser Gln Gly Ala Ser Glu Ser
1055 1060 1065
Gln Ala Pro Gly Glu Glu Asn Leu Leu Gly Glu Ala Ala Gly Gly
1070 1075 1080
Gln Asp Met Ala Asp Ser Met Leu Met Gln Gly Ser Arg Gly Leu
1085 1090 1095
Thr Asp Gln Ala Ile Phe Tyr Ala Val Thr Pro Leu Pro Trp Cys
1100 1105 1110
Pro His Leu Val Ala Val Cys Pro Ile Pro Ala Ala Gly Leu Asp
1115 1120 1125
Val Thr Gln Pro Cys Gly Asp Cys Gly Thr Ile Gln Glu Asn Trp
1130 1135 1140
Val Cys Leu Ser Cys Tyr Gln Val Tyr Cys Gly Arg Tyr Ile Asn
1145 1150 1155
Gly His Met Leu Gln His His Gly Asn Ser Gly His Pro Leu Val
1160 1165 1170
Leu Ser Tyr Ile Asp Leu Ser Ala Trp Cys Tyr Tyr Cys Gln Ala
1175 1180 1185
Tyr Val His His Gln Ala Leu Leu Asp Val Lys Asn Ile Ala His
1190 1195 1200
Gln Asn Lys Phe Gly Glu Asp Met Pro His Pro His
1205 1210 1215
<210>186
<211>780
<212>PRT
<213>人
<400>186
Met Ala Pro Tyr Ser Leu Leu Val Thr Arg Leu Gln Lys Ala Leu Gly
1 5 10 15
Val Arg Gln Tyr His Val Ala Ser Val Leu Cys Gln Arg Ala Lys Val
20 25 30
Ala Met Ser His Phe Glu Pro Asn Glu Tyr Ile His Tyr Asp Leu Leu
35 40 45
Glu Lys Asn Ile Asn Ile Val Arg Lys Arg Leu Asn Arg Pro Leu Thr
50 55 60
Leu Ser Glu Lys Ile Val Tyr Gly His Leu Asp Asp Pro Ala Ser Gln
65 70 75 80
Glu Ile Glu Arg Gly Lys Ser Tyr Leu Arg Leu Arg Pro Asp Arg Val
85 90 95
Ala Met Gln Asp Ala Thr Ala Gln Met Ala Met Leu Gln Phe Ile Ser
100 105 110
Ser Gly Leu Ser Lys Val Ala Val Pro Ser Thr Ile His Cys Asp His
115 120 125
Leu Ile Glu Ala Gln Val Gly Gly Glu Lys Asp Leu Arg Arg Ala Lys
130 135 140
Asp Ile Asn Gln Glu Val Tyr Asn Phe Leu Ala Thr Ala Gly Ala Lys
145 150 155 160
Tyr Gly Val Gly Phe Trp Lys Pro Gly Ser Gly Ile Ile His Gln Ile
165 170 175
Ile Leu Glu Asn Tyr Ala Tyr Pro Gly Val Leu Leu Ile Gly Thr Asp
180 185 190
Ser His Thr Pro Asn Gly Gly Gly Leu Gly Gly Ile Cys Ile Gly Val
195 200 205
Gly Gly Ala Asp Ala Val Asp Val Met Ala Gly Ile Pro Trp Glu Leu
210 215 220
Lys Cys Pro Lys Val Ile Gly Val Lys Leu Thr Gly Ser Leu Ser Gly
225 230 235 240
Trp Ser Ser Pro Lys Asp Val Ile Leu Lys Val Ala Gly Ile Leu Thr
245 250 255
Val Lys Gly Gly Thr Gly Ala Ile Val Glu Tyr His Gly Pro Gly Val
260 265 270
Asp Ser Ile Ser Cys Thr Gly Met Ala Thr Ile Cys Asn Met Gly Ala
275 280 285
Glu Ile Gly Ala Thr Thr Ser Val Phe Pro Tyr Asn His Arg Met Lys
290 295 300
Lys Tyr Leu Ser Lys Thr Gly Arg Glu Asp Ile Ala Asn Leu Ala Asp
305 310 315 320
Glu Phe Lys Asp His Leu Val Pro Asp Pro Gly Cys His Tyr Asp Gln
325 330 335
Leu Ile Glu Ile Asn Leu Ser Glu Leu Lys Pro His Ile Asn Gly Pro
340 345 350
Phe Thr Pro Asp Leu Ala His Pro Val Ala Glu Val Gly Lys Val Ala
355 360 365
Glu Lys Glu Gly Trp Pro Leu Asp Ile Arg Val Gly Leu Ile Gly Ser
370 375 380
Cys Thr Asn Ser Ser Tyr Glu Asp Met Gly Arg Ser Ala Ala Val Ala
385 390 395 400
Lys Gln Ala Leu Ala His Gly Leu Lys Cys Lys Ser Gln Phe Thr Ile
405 410 415
Thr Pro Gly Ser Glu Gln Ile Arg Ala Thr Ile Glu Arg Asp Gly Tyr
420 425 430
Ala Gln Ile Leu Arg Asp Leu Gly Gly Ile Val Leu Ala Asn Ala Cys
435 440 445
Gly Pro Cys Ile Gly Gln Trp Asp Arg Lys Asp Ile Lys Lys Gly Glu
450 455 460
Lys Asn Thr Ile Val Thr Ser Tyr Asn Arg Asn Phe Thr Gly Arg Asn
465 470 475 480
Asp Ala Asn Pro Glu Thr His Ala Phe Val Thr Ser Pro Glu Ile Val
485 490 495
Thr Ala Leu Ala Ile Ala Gly Thr Leu Lys Phe Asn Pro Glu Thr Asp
500 505 510
Tyr Leu Thr Gly Thr Asp Gly Lys Lys Phe Arg Leu Glu Ala Pro Asp
515 520 525
Ala Asp Glu Leu Pro Lys Gly Glu Phe Asp Pro Gly Gln Asp Thr Tyr
530 535 540
Gln His Pro Pro Lys Asp Ser Ser Gly Gln His Val Asp Val Ser Pro
545 550 555 560
Thr Ser Gln Arg Leu Gln Leu Leu Glu Pro Phe Asp Lys Trp Asp Gly
565 570 575
Lys Asp Leu Glu Asp Leu Gln Ile Leu Ile Lys Val Lys Gly Lys Cys
580 585 590
Thr Thr Asp His Ile Ser Ala Ala Gly Pro Trp Leu Lys Phe Arg Gly
595 600 605
His Leu Asp Asn Ile Ser Asn Asn Leu Leu Ile Gly Ala Ile Asn Ile
610 615 620
Glu Asn Gly Lys Ala Asn Ser Val Arg Asn Ala Val Thr Gln Glu Phe
625 630 635 640
Gly Pro Val Pro Asp Thr Ala Arg Tyr Tyr Lys Lys His Gly Ile Arg
645 650 655
Trp Val Val Ile Gly Asp Glu Asn Tyr Gly Glu Gly Ser Ser Arg Glu
660 665 670
His Ala Ala Leu Glu Pro Arg His Leu Gly Gly Arg Ala Ile Ile Thr
675 680 685
Lys Ser Phe Ala Arg Ile His Glu Thr Asn Leu Lys Lys Gln Gly Leu
690 695 700
Leu Pro Leu Thr Phe Ala Asp Pro Ala Asp Tyr Asn Lys Ile His Pro
705 710 715 720
Val Asp Lys Leu Thr Ile Gln Gly Leu Lys Asp Phe Thr Pro Gly Lys
725 730 735
Pro Leu Lys Cys Ile Ile Lys His Pro Asn Gly Thr Gln Glu Thr Ile
740 745 750
Ieu Leu Asn His Thr Phe Asn Glu Thr Gln Ile Glu Trp Phe Arg Ala
755 760 765
Gly Ser Ala Leu Asn Arg Met Lys Glu Leu Gln Gln
770 775 780
<210>187
<211>650
<212>PRT
<213>人
<400>187
Met Gly Pro Ala Ser Pro Ala Ala Arg Gly Leu Ser Arg Arg Pro Gly
1 5 10 15
Gln Pro Pro Leu Pro Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Arg
20 25 30
Ala Gln Pro Ala Ile Gly Ser Leu Ala Gly Gly Ser Pro Gly Ala Ala
35 40 45
Glu Ala Pro Gly Ser Ala Gln Val Ala Gly Leu Cys Gly Arg Leu Thr
50 55 60
Leu His Arg Asp Leu Arg Thr Gly Arg Trp Glu Pro Asp Pro Gln Arg
65 70 75 80
Ser Arg Arg Cys Leu Arg Asp Pro Gln Arg Val Leu Glu Tyr Cys Arg
85 90 95
Gln Met Tyr Pro Glu Leu Gln Ile Ala Arg Val Glu Gln Ala Thr Gln
100 105 110
Ala Ile Pro Met Glu Arg Trp Cys Gly Gly Ser Arg Ser Gly Ser Cys
115 120 125
Ala His Pro His His Gln Val Val Pro Phe Arg Cys Leu Pro Gly Glu
130 135 140
Phe Val Ser Glu Ala Leu Leu Val Pro Glu Gly Cys Arg Phe Leu His
145 150 155 160
Gln Glu Arg Met Asp Gln Cys Glu Ser Ser Thr Arg Arg His Gln Glu
165 170 175
Ala Gln Glu Ala Cys Ser Ser Gln Gly Leu Ile Leu His Gly Ser Gly
180 185 190
Met Leu Leu Pro Cys Gly Ser Asp Arg Phe Arg Gly Val Glu Tyr Val
195 200 205
Cys Cys Pro Pro Pro Gly Thr Pro Asp Pro Ser Gly Thr Ala Val Gly
210 215 220
Asp Pro Ser Thr Arg Ser Trp Pro Pro Gly Ser Arg Val Glu Gly Ala
225 230 235 240
Glu Asp Glu Glu Glu Glu Glu Ser Phe Pro Gln Pro Val Asp Asp Tyr
245 250 255
Phe Val Glu Pro Pro Gln Ala Glu Glu Glu Glu Glu Thr Val Pro Pro
260 265 270
Pro Ser Ser His Thr Leu Ala Val Val Gly Lys Val Thr Pro Thr Pro
275 280 285
Arg Pro Thr Asp Gly Val Asp Ile Tyr Phe Gly Met Pro Gly Glu Ile
290 295 300
Ser Glu His Glu Gly Phe Leu Arg Ala Lys Met Asp Leu Glu Glu Arg
305 310 315 320
Arg Met Arg Gln Ile Asn Glu Val Met Arg Glu Trp Ala Met Ala Asp
325 330 335
Asn Gln Ser Lys Asn Leu Pro Lys Ala Asp Arg Gln Ala Leu Asn Glu
340 345 350
His Phe Gln Ser Ile Leu Gln Thr Leu Glu Glu Gln Val Ser Gly Glu
355 360 365
Arg Gln Arg Leu Val Glu Thr His Ala Thr Arg Val Ile Ala Leu Ile
370 375 380
Asn Asp Gln Arg Arg Ala Ala Leu Glu Gly Phe Leu Ala Ala Leu Gln
385 390 395 400
Ala Asp Pro Pro Gln Ala Glu Arg Val Leu Leu Ala Leu Arg Arg Tyr
405 410 415
Leu Arg Ala Glu Gln Lys Glu Gln Arg His Thr Leu Arg His Tyr Gln
420 425 430
His Val Ala Ala Val Asp Pro Glu Lys Ala Gln Gln Met Arg Phe Gln
435 440 445
Val His Thr His Leu Gln Val Ile Glu Glu Arg Val Asn Gln Ser Leu
450 455 460
Gly Leu Leu Asp Gln Asn Pro His Leu Ala Gln Glu Leu Arg Pro Gln
465 470 475 480
Ile Gln Glu Leu Leu His Ser Glu His Leu Gly Pro Ser Glu Leu Glu
485 490 495
Ala Pro Ala Pro Gly Gly Ser Ser Glu Asp Lys Gly Gly Leu Gln Pro
500 505 510
Pro Asp Ser Lys Asp Asp Thr Pro Met Thr Leu Pro Lys Gly Ser Thr
515 520 525
Glu Gln Asp Ala Ala Ser Pro Glu Lys Glu Lys Met Asn Pro Leu Glu
530 535 540
Gln Tyr Glu Arg Lys Val Asn Ala Ser Val Pro Arg Gly Phe Pro Phe
545 550 555 560
His Ser Ser Glu Ile Gln Arg Asp Glu Leu Ala Pro Ala Gly Thr Gly
565 570 575
Val Ser Arg Glu Ala Val Ser Gly Leu Leu Ile Met Gly Ala Gly Gly
580 585 590
Gly Ser Leu Ile Val Leu Ser Met Leu Leu Leu Arg Arg Lys Lys Pro
595 600 605
Tyr Gly Ala Ile Ser His Gly Val Val Glu Val Asp Pro Met Leu Thr
610 615 620
Leu Glu Glu Gln Gln Leu Arg Glu Leu Gln Arg His Gly Tyr Glu Asn
625 630 635 640
Pro Thr Tyr Arg Phe Leu Glu Glu Arg Pro
645 650
<210>188
<211>651
<213>人
<400>188
Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val
1 5 10 15
Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val
20 25 30
Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu
35 40 45
Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg
50 55 60
Leu Lys Ala Glu Arg Lys Phe Phe Lys Gly Phe Phe Gly Lys Thr Gly
65 70 75 80
Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser Ala Asp Gly Leu Arg
85 90 95
Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val Asp Gln Thr Ile Glu
100 105 110
Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe Asp Arg Ala Phe Ser
115 120 125
Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp Ile Cys His Cys Phe
130 135 140
Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser His Ala Val Gly Cys
145 150 155 160
Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys Arg Glu Lys Glu Cys
165 170 175
Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr Thr Phe Thr Arg Glu
180 185 190
Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln Ala Glu Arg Glu Glu
195 200 205
Ile Met Lys Gln Met Gln Asp Ala Lys Lys Ala Glu Thr Asp Lys Ile
210 215 220
Val Val Gly Ser Ser Val Ala Pro Gly Asn Thr Ala Pro Ser Pro Ser
225 230 235 240
Ser Pro Thr Ser Pro Thr Ser Asp Ala Thr Thr Ser Leu Glu Met Asn
245 250 255
Asn Pro His Ala Ile Pro Arg Arg His Ala Pro Ile Glu Gln Leu Ala
260 265 270
Arg Gln Gly Ser Phe Arg Gly Phe Pro Ala Leu Ser Gln Lys Met Ser
275 280 285
Pro Phe Lys Arg Gln Leu Ser Leu Arg Ile Asn Glu Leu Pro Ser Thr
290 295 300
Met Gln Arg Lys Thr Asp Phe Pro Ile Lys Asn Ala Val Pro Glu Val
305 310 315 320
Glu Gly Glu Ala Glu Ser Ile Ser Ser Leu Cys Ser Gln Ile Thr Asn
325 330 335
Ala Phe Ser Thr Pro Glu Asp Pro Phe Ser Ser Ala Pro Met Thr Lys
340 345 350
Pro Val Thr Val Val Ala Pro Gln Ser Pro Thr Phe Gln Ala Asn Gly
355 360 365
Thr Asp Ser Ala Phe His Val Leu Ala Lys Pro Ala His Thr Ala Leu
370 375 380
Ala Pro Val Ala Met Pro Val Arg Glu Thr Asn Pro Trp Ala His Ala
385 390 395 400
Pro Asp Ala Ala Asn Lys Glu Ile Ala Ala Thr Cys Ser Gly Thr Glu
405 410 415
Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly Leu Phe Gln Ala Gly
420 425 430
His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp Leu Glu Glu Val Ser
435 440 445
Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser Ala Ala Pro Leu Gln
450 455 460
Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile Ser Gln Pro Ala Ser
465 470 475 480
Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln Pro Val Pro Val Gly
485 490 495
Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro Ala Gln Ser Tyr Pro
500 505 510
Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn Val Pro Val Val Gly
515 520 525
Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe Gly Thr Ala Gly His
530 535 540
Pro Gln Ala Ala His Pro His Gln Ser Pro Ser Leu Val Arg Gln Gln
545 550 555 560
Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr Thr Ser Pro Phe Phe
565 570 575
Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala Ala Phe Asn Gly Val
580 585 590
Asp Asp Gly Arg Leu Ala ser Ala Asp Arg His Thr Glu Val Pro Thr
595 600 605
Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln Trp Ala Ala Leu Glu
610 615 620
Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro Thr Asn Pro Phe Ser
625 630 635 640
Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu
645 650
<210>189
<211>803
<212>PRT
<213>人
<400>189
Met Asn Ser Ala Glu Gln Thr Val Thr Trp Leu Ile Thr Leu Gly Val
1 5 10 15
Leu Glu Ser Pro Lys Lys Thr Ile Ser Asp Pro Glu Gly Phe Leu Gln
20 25 30
Ala Ser Leu Lys Asp Gly Val Val Leu Cys Arg Leu Leu Glu Arg Leu
35 40 45
Leu Pro Gly Thr Ile Glu Lys Val Tyr Pro Glu Pro Arg Ser Glu Ser
50 55 60
Glu Cys Leu Ser Asn Ile Arg Glu Phe Leu Arg Gly Cys Gly Ala Ser
65 70 75 80
Leu Arg Leu Glu Leu Leu Phe Pro Pro Ser Gln Pro Pro Gln His Leu
85 90 95
Val Thr Thr Ile Leu Leu Ser Ala Ser Thr Phe Asp Ala Asn Asp Leu
100 105 110
Tyr Gln Gly Gln Asn Phe Asn Lys Val Leu Ser Ser Leu Val Thr Leu
115 120 125
Asn Lys Val Thr Ala Asp Ile Gly Leu Gly Ser Asp Ser Val Cys Ala
130 135 140
Arg Pro Ser Ser His Arg Ile Lys Ser Phe Asp Ser Leu Gly Ser Gln
145 150 155 160
Ser Leu His Thr Arg Thr Ser Lys Leu Phe Gln Gly Gln Tyr Arg Ser
165 170 175
Leu Asp Met Thr Asp Asn Ser Asn Asn Gln Leu Val Val Arg Ala Lys
180 185 190
Phe Asn Phe Gln Gln Thr Asn Glu Asp Glu Leu Ser Phe Ser Lys Gly
195 200 205
Asp Val Ile His Val Thr Arg Val Glu Glu Gly Gly Trp Trp Glu Gly
210 215 220
Thr Leu Asn Gly Arg Thr Gly Trp Phe Pro Ser Asn Tyr Val Arg Glu
225 230 235 240
Val Lys Ala Ser Glu Lys Pro Val Ser Pro Lys Ser Gly Thr Leu Lys
245 250 255
Ser Pro Pro Lys Gly Phe Asp Thr Thr Ala Ile Asn Lys Ser Tyr Tyr
260 265 270
Asn Val Val Leu Gln Asn Ile Leu Glu Thr Glu Asn Glu Tyr Ser Lys
275 280 285
Glu Leu Gln Thr Val Leu Ser Thr Tyr Leu Arg Pro Leu Gln Thr Ser
290 295 300
Glu Lys Leu Ser Ser Ala Asn Ile Ser Tyr Leu Met Gly Asn Leu Glu
305 310 315 320
Glu Ile Cys Ser Phe Gln Gln Met Leu Val Gln Ser Leu Glu Glu Cys
325 330 335
Thr Lys Leu Pro Glu Ala Gln Gln Arg Val Gly Gly Cys Phe Leu Asn
340 345 350
Leu Met Pro Gln Met Lys Thr Leu Tyr Leu Thr Tyr Cys Ala Asn His
355 360 365
Pro Ser Ala Val Asn Val Leu Thr Glu His Ser Glu Glu Leu Gly Glu
370 375 380
Phe Met Glu Thr Lys Gly Ala Ser Ser Pro Gly Ile Leu Val Leu Thr
385 390 395 400
Thr Gly Leu Ser Lys Pro Phe Met Arg Leu Asp Lys Tyr Pro Thr Leu
405 410 415
Leu Lys Glu Leu Glu Arg His Met Glu Asp Tyr His Thr Asp Arg Gln
420 425 430
Asp Ile Gln Lys Ser Met Ala Ala Phe Lys Asn Leu Ser Ala Gln Cys
435 440 445
Gln Glu Val Arg Lys Arg Lys Glu Leu Glu Leu Gln Ile Leu Thr Glu
450 455 460
Ala Ile Arg Asn Trp Glu Gly Asp Asp Ile Lys Thr Leu Gly Asn Val
465 470 475 480
Thr Tyr Met Ser Gln Val Leu Ile Gln Cys Ala Gly Ser Glu Glu Lys
485 490 495
Asn Glu Arg Tyr Leu Leu Leu Phe Pro Asn Val Leu Leu Met Leu Ser
500 505 510
Ala Ser Pro Arg Met Ser Gly Phe Ile Tyr Gln Gly Lys Leu Pro Thr
515 520 525
Thr Gly Met Thr Ile Thr Lys Leu Glu Asp Ser Glu Asn His Arg Asn
530 535 540
Ala Phe Glu Ile Ser Gly Ser Met Ile Glu Arg Ile Leu Val Ser Cys
545 550 555 560
Asn Asn Gln Gln Asp Leu Gln Glu Trp Val Glu His Leu Gln Lys Gln
565 570 575
Thr Lys Val Thr Ser Val Gly Asn Pro Thr Ile Lys Pro His Ser Val
580 585 590
Pro Ser His Thr Leu Pro Ser His Pro Val Thr Pro Ser Ser Lys His
595 600 605
Ala Asp Ser Lys Pro Ala Pro Leu Thr Pro Ala Tyr His Thr Leu Pro
610 615 620
His Pro Ser His His Gly Thr Pro His Thr Thr Ile Asn Trp Gly Pro
625 630 635 640
Leu Glu Pro Pro Lys Thr Pro Lys Pro Trp Ser Leu Ser Cys Leu Arg
645 650 655
Pro Ala Pro Pro Leu Arg Pro Ser Ala Ala Leu Cys Tyr Lys Glu Asp
660 665 670
Leu Ser Lys Ser Pro Lys Thr Met Lys Lys Leu Leu Pro Lys Arg Lys
675 680 685
Pro Glu Arg Lys Pro Ser Asp Glu Glu Phe Ala Ser Arg Lys Ser Thr
690 695 700
Ala Ala Leu Glu Glu Asp Ala Gln Ile Leu Lys Val Ile Glu Ala Tyr
705 710 715 720
Cys Thr Ser Ala Lys Thr Arg Gln Thr Leu Asn Ser Thr Trp Gln Gly
725 730 735
Thr Asp Leu Met His Asn His Val Leu Ala Asp Asp Asp Gln Pro Ser
740 745 750
Leu Asp Ser Leu Gly Arg Arg Ser Ser Leu Ser Arg Leu Glu Pro Ser
755 760 765
Asp Leu Ser Glu Asp Ser Asp Tyr Asp Ser Ile Trp Thr Ala His Ser
770 775 780
Tyr Arg Met Gly Ser Thr Ser Arg Lys Ser Cys Cys Ser Tyr Ile Ser
785 790 795 800
His Gln Asn
<210>190
<211>353
<212>PRT
<213>人
<400>190
Met Ala Cys Cys Leu Ser Glu Glu Ala Lys Glu Ala Arg Arg Ile Asn
1 5 10 15
Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp Lys Arg Asp Ala Arg Arg
20 25 30
Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly Glu Ser Gly Lys Ser Thr
35 40 45
Phe Ile Lys Gln Met Arg Ile Ile His Gly Ser Gly Tyr Ser Asp Glu
50 55 60
Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr Gln Asn Ile Phe Thr Ala
65 70 75 80
Met Gln Ala Met Ile Arg Ala Met Asp Thr Leu Lys Ile Pro Tyr Lys
85 90 95
Tyr Glu His Asn Lys Ala His Ala Gln Leu Val Arg Glu Val Asp Val
100 105 110
Glu Lys Val Ser Ala Phe Glu Asn Pro Tyr Val Asp AlaIle Lys Ser
115 120 125
Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys Tyr Asp Arg Arg Arg Glu
130 135 140
Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr Leu Asn Asp Leu Asp Arg
145 150 155 160
Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln Gln Asp Val Leu Arg Val
165 170 175
Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr Pro Phe Asp Leu Gln Ser
180 185 190
Val Ile Phe Arg Met Val Asp Val Gly Gly Gln Arg Ser Glu Arg Arg
195 200 205
Lys Trp Ile His Cys Phe Glu Asn Val Thr Ser Ile Met Phe Leu Val
210 215 220
Ala Leu Ser Glu Tyr Asp Gln Val Leu Val Glu Ser Asp Asn Glu Asn
225 230 235 240
Arg Met Glu Glu Ser Lys Ala Leu Phe Arg Thr Ile Ile Thr Tyr Pro
245 250 255
Trp Phe Gln Asn Ser Ser Val Ile Leu Phe Leu Asn Lys Lys Asp Leu
260 265 270
Leu Glu Glu Lys Ile Met Tyr Ser His Leu Val Asp Tyr Phe Pro Glu
275 280 285
Tyr Asp Gly Pro Gln Arg Asp Ala Gln Ala Ala Arg Glu Phe Ile Leu
290 295 300
Lys Met Phe Val Asp Leu Asn Pro Asp Ser Asp Lys Ile Ile Tyr Ser
305 310 315 320
His Phe Thr Cys Ala Thr Asp Thr Glu Asn Ile Arg Phe Val Phe Ala
325 330 335
Ala Val Lys Asp Thr Ile Leu Gln Leu Asn Leu Lys Glu Tyr Asn Leu
340 345 350
Val
<210>191
<211>394
<212>PRT
<213>人
<400>191
Met Ala Leu Leu Asp Leu Ala Leu Glu Gly Met Ala Val Phe Gly Phe
1 5 10 15
Aal Leu Phe Leu Val Leu Trp Leu Met His Phe Met Ala Ile Ile Tyr
20 25 30
Thr Arg Leu His Leu Asn Lys Lys Ala Thr Asp Lys Gln Pro Tyr Ser
35 40 45
Lys Leu Pro Gly Val Ser Leu Leu Lys Pro Leu Lys Gly Val Asp Pro
50 55 60
Asn Leu Ile Asn Asn Leu Glu Thr Phe Phe Glu Leu Asp Tyr Pro Lys
65 70 75 80
Tyr Glu Val Leu Leu Cys Val Gln Asp His Asp Asp Pro Ala Ile Asp
85 90 95
Val Cys Lys Lys Leu Leu Gly Lys Tyr Pro Asn Val Asp Ala Arg Leu
100 105 110
Phe Ile Gly Gly Lys Lys Val Gly Ile Asn Pro Lys Ile Asn Asn Leu
115 120 125
Met Pro Gly Tyr Glu Val Ala Lys Tyr Asp Leu Ile Trp Ile Cys Asp
130 135 140
Ser Gly Ile Arg Val Ile Pro Asp Thr Leu Thr Asp Met Val Asn Gln
145 150 155 160
Met Thr Glu Lys Val Gly Leu Val His Gly Leu Pro Tyr Val Ala Asp
165 170 175
Arg Gln Gly Phe Ala Ala Thr Leu Glu Gln Val Tyr Phe Gly Thr Ser
180 185 190
His Pro Arg Tyr Tyr Ile Ser Ala Asn Val Thr Gly Phe Lys Cys Val
195 200 205
Thr Gly Met Ser Cys Leu Met Arg Lys Asp Val Leu Asp Gln Ala Gly
210 215 220
Gly Leu Ile Ala Phe Ala Gln Tyr Ile Ala Glu Asp Tyr Phe Met Ala
225 230 235 240
Lys Ala Ile Ala Asp Arg Gly Trp Arg Phe Ala Met Ser Thr Gln Val
245 250 255
Ala Met Gln Asn Ser Gly Ser Tyr Ser Ile Ser Gln Phe Gln Ser Arg
260 265 270
Met Ile Arg Trp Thr Lys Leu Arg Ile Asn Met Leu Pro Ala Thr Ile
275 280 285
Ile Cys Glu Pro Ile Ser Glu Cys Phe Val Ala Ser Leu Ile Ile Gly
290 295 300
Trp Ala Ala His His Val Phe Arg Trp Asp Ile Met Val Phe Phe Met
305 310 315 320
Cys His Cys Leu Ala Trp Phe Ile Phe Asp Tyr Ile Gln Leu Arg Gly
325 330 335
Val Gln Gly Gly Thr Leu Cys Phe Ser Lys Leu Asp Tyr Ala Val Ala
340 345 350
Trp Phe Ile Arg Glu Ser Met Thr Ile Tyr Ile Phe Leu Ser Ala Leu
355 360 365
Trp Asp Pro Thr Ile Ser Trp Arg Thr Gly Arg Tyr Arg Leu Arg Cys
370 375 380
Gly Gly Thr Ala Glu Glu Ile Leu Asp Val
385 390
<210>192
<211>660
<212>PRT
<213>人
<400>192
Met Glu Ala Leu Met Ala Arg Gly Ala Leu Thr Gly Pro Leu Arg Ala
1 5 10 15
Leu Cys Leu Leu Gly Cys Leu Leu Ser His Ala Ala Ala Ala Pro Ser
20 25 30
Pro Ile Ile Lys Phe Pro Gly Asp Val Ala Pro Lys Thr Asp Lys Glu
35 40 45
Leu Ala Val Gln Tyr Leu Asn Thr Phe Tyr Gly Cys Pro Lys Glu Ser
50 55 60
Cys Asn Leu Phe Val Leu Lys Asp Thr Leu Lys Lys Met Gln Lys Phe
65 70 75 80
Phe Gly Leu Pro Gln Thr Gly Asp Leu Asp Gln Asn Thr Ile Glu Thr
85 90 95
Met Arg Lys Pro Arg Cys Gly Asn Pro Asp Val Ala Asn Tyr Asn Phe
100 105 110
Phe Pro Arg Lys Pro Lys Trp Asp Lys Asn Gln Ile Thr Tyr Arg Ile
115 120 125
Ile Gly Tyr Thr Pro Asp Leu Asp Pro Glu Thr Val Asp Asp Ala Phe
130 135 140
Ala Arg Ala Phe Gln Val Trp Ser Asp Val Thr Pro Leu Arg Phe Ser
145 150 155 160
Arg Ile His Asp Gly Glu Ala Asp Ile Met Ile Asn Phe Gly Arg Trp
165 170 175
Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala
180 185 190
His Ala Phe Ala Pro Gly Thr Gly Val Gly Gly Asp Ser His Phe Asp
195 200 205
Asp Asp Glu Leu Trp Thr Leu Gly Glu Gly Gln Val Val Arg Val Lys
210 215 220
Tyr Gly Asn Ala Asp Gly Glu Tyr Cys Lys Phe Pro Phe Leu Phe Asn
225 230 235 240
Gly Lys Glu Tyr Asn Ser Cys Thr Asp Thr Gly Arg Ser Asp Gly Phe
245 250 255
Leu Trp Cys Ser Thr Thr Tyr Asn Phe Glu Lys Asp Gly Lys Tyr Gly
260 265 270
Phe Cys Pro His Glu Ala Leu Phe Thr Met Gly Gly Asn Ala Glu Gly
275 280 285
Gln Pro Cys Lys Phe Pro Phe Arg Phe Gln Gly Thr Ser Tyr Asp Ser
290 295 300
Cys Thr Thr Glu Gly Arg Thr Asp Gly Tyr Arg Trp Cys Gly Thr Thr
305 310 315 320
Glu Asp Tyr Asp Arg Asp Lys Lys Tyr Gly Phe Cys Pro Glu Thr Ala
325 330 335
Met Ser Thr Val Gly Gly Asn Ser Glu Gly Ala Pro Cys Val Phe Pro
340 345 350
Phe Thr Phe Leu Gly Asn Lys Tyr Glu Ser Cys Thr Ser Ala Gly Arg
355 360 365
Ser Asp Gly Lys Met Trp Cys Ala Thr Thr Ala Asn Tyr Asp Asp Asp
370 375 380
Arg Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val
385 390 395 400
Ala Ala His Glu Phe Gly His Ala Met Gly Leu Glu His Ser Gln Asp
405 410 415
Pro Gly Ala Leu Met Ala Pro Ile Tyr Thr Tyr Thr Lys Asn Phe Arg
420 425 430
Leu Ser Gln Asp Asp Ile Lys Gly Ile Gln Glu Leu Tyr Gly Ala Ser
435 440 445
Pro Asp Ile Asp Leu Gly Thr Gly Pro Thr Pro Thr Leu Gly Pro Val
450 455 460
Thr Pro Glu Ile Cys Lys Gln Asp Ile Val Phe Asp Gly Ile Ala Gln
465 470 475 480
Ile Arg Gly Glu Ile Phe Phe Phe Lys Asp Arg Phe Ile Trp Arg Thr
485 490 495
Val Thr Pro Arg Asp Lys Pro Met Gly Pro Leu Leu Val Ala Thr Phe
500 505 510
Trp Pro Glu Leu Pro Glu Lys Ile Asp Ala Val Tyr Glu Ala Pro Gln
515 520 525
Glu Glu Lys Ala Val Phe Phe Ala Gly Asn Glu Tyr Trp Ile Tyr Ser
530 535 540
Ala Ser Thr Leu Glu Arg Gly Tyr Pro Lys Pro Leu Thr Ser Leu Gly
545 550 555 560
Leu Pro Pro Asp Val Gln Arg Val Asp Ala Ala Phe Asn Trp Ser Lys
565 570 575
Asn Lys Lys Thr Tyr Ile Phe Ala Gly Asp Lys Phe Trp Arg Tyr Asn
580 585 590
Glu Val Lys Lys Lys Met Asp Pro Gly Phe Pro Lys Leu Ile Ala Asp
595 600 605
Ala Trp Asn Ala Ile Pro Asp Asn Leu Asp Ala Val Val Asp Leu Gln
610 615 620
Gly Gly Gly His Ser Tyr Phe Phe Lys Gly Ala Tyr Tyr Leu Lys Leu
625 630 635 640
Glu Asn Gln Ser Leu Lys Ser Val Lys Phe Gly Ser Ile Lys Ser Asp
645 650 655
Trp Leu Gly Cys
660
<210>193
<211>260
<212>PRT
<213>人
<400>193
Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val
1 5 10 15
Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr
20 25 30
Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe
35 40 45
Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro
50 55 60
Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His
65 70 75 80
Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys
85 90 95
Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys
100 105 110
Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu
115 120 125
Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His
130 135 140
Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met
145 150 155 160
Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr
165 170 175
His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile
180 185 190
Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala
195 200 205
Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser
210 215 220
Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu
225 230 235 240
Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro
245 250 255
Ala Cys Ser Pro
260
<210>194
<211>885
<212>PRT
<213>人
<400>194
Met Gly Cys Ala Pro Ser Ile His Val Ser Gln Ser Gly Val Ile Tyr
1 5 10 15
Cys Arg Asp Ser Asp Glu Ser Ser Ser Pro Arg Gln Thr Thr Ser Val
20 25 30
Ser Gln Gly Pro Ala Ala Pro Leu Pro Gly Leu Phe Val Gln Thr Asp
35 40 45
Ala Ala Asp Ala Ile Pro Pro Ser Arg Ala Ser Gly Pro Pro Ser Val
50 55 60
Ala Arg Val Arg Arg Ala Arg Thr Glu Leu Gly Ser Gly Ser Ser Ala
65 70 75 80
Gly Ser Ala Ala Pro Ala Ala Thr Thr Ser Arg Gly Arg Arg Arg His
85 90 95
Cys Cys Ser Ser Ala Glu Ala Glu Thr Gln Thr Cys Tyr Thr Ser Val
100 105 110
Lys Gln Val Ser Ser Ala Glu Val Arg Ile Gly Pro Met Arg Leu Thr
115 120 125
Gln Asp Pro Ile Gln Val Leu Leu Ile Phe Ala Lys Glu Asp Ser Gln
130 135 140
Ser Asp Gly Phe Trp Trp Ala Cys Asp Arg Ala Gly Tyr Arg Cys Asn
145 150 155 160
Ile Ala Arg Thr Pro Glu Ser Ala Leu Glu Cys Phe Leu Asp Lys His
165 170 175
His Glu Ile Ile ValIle Asp His Arg Gln Thr Gln Asn Phe Asp Ala
180 185 190
Glu Ala Val Cys Arg Ser Ile Arg Ala Thr Asn Pro Ser Glu His Thr
195 200 205
Val Ile Leu Ala Val Val Ser Arg Val Ser Asp Asp His Glu Glu Ala
210 215 220
Ser Val Leu Pro Leu Leu His Ala Gly Phe Asn Arg Arg Phe Met Glu
225 230 235 240
Asn Ser Ser Ile Ile Ala Cys Tyr Asn Glu Leu Ile Gln Ile Glu His
245 250 255
Gly Glu Val Arg Ser Gln Phe Lys Leu Arg Ala Cys Asn Ser Val Phe
260 265 270
Thr Ala Leu Asp His Cys His Glu Ala Ile Glu Ile Thr Ser Asp Asp
275 280 285
His Val Ile Gln Tyr Val Asn Pro Ala Phe Glu Arg Met Met Gly Tyr
290 295 300
His Lys Gly Glu Leu Leu Gly Lys Glu Leu Ala Asp Leu Pro Lys Ser
305 310 315 320
Asp Lys Asn Arg Ala Asp Leu Leu Asp Thr Ile Asn Thr Cys Ile Lys
325 330 335
Lys Gly Lys Glu Trp Gln Gly Val Tyr Tyr Ala Arg Arg Lys Ser Gly
340 345 350
Asp Ser Ile Gln Gln His Val Lys Ile Thr Pro Val Ile Gly Gln Gly
355 360 365
Gly Lys Ile Arg Hi s Phe Val Ser Leu Lys Lys Leu Cys Cys Thr Thr
370 375 380
Asp Asn Asn Lys Gln Ile His Lys Ile His Arg Asp Ser Gly Asp Asn
385 390 395 400
Ser Gln Thr Glu Pro His Ser Phe Arg Tyr Lys Asn Arg Arg Lys Glu
405 4l0 4l5
Ser Ile Asp Val Lys Ser Ile Ser Ser Arg Gly Ser Asp Ala Pro Ser
420 425 430
Leu Gln Asn Arg Arg Tyr Pro Ser Met Ala Arg Ile His Ser Met Thr
435 440 445
Ile Glu Ala Pro Ile Thr Lys Val Ile Asn Ile Ile Asn Ala Ala Gln
450 455 460
Glu Asn Ser Pro Val Thr Val Ala Glu Ala Leu Asp Arg Val Leu Glu
465 470 475 480
Ile Leu Arg Thr Thr Glu Leu Tyr Ser Pro Gln Leu Gly Thr Lys Asp
485 490 495
Glu Asp Pro His Thr Ser Asp Leu Val Gly Gly Leu Met Thr Asp Gly
500 505 510
Leu Arg Arg Leu Ser Gly Asn Glu Tyr Val Phe Thr Lys Asn Val His
515 520 525
Gln Ser His Ser His Leu Ala Met Pro Ile Thr Ile Asn Asp Val Pro
530 535 540
Pro Cys Ile Ser Gln Leu Leu Asp Asn Glu Glu Ser Trp Asp Phe Asn
545 550 555 560
Ille Phe Glu Leu Glu Ala Ile Thr His Lys Arg Pro Leu Val Tyr Leu
565 570 575
Gly Leu Lys Val Phe Ser Arg Phe Gly Val Cys Glu Phe Leu Asn Cys
580 585 590
Ser Glu Thr Thr Leu Arg Ala Trp Phe Gln Val Ile Glu Ala Asn Tyr
595 600 605
His Ser Ser Asn Ala Tyr His Asn Ser Thr His Ala Ala Asp Val Leu
610 615 620
His Ala Thr Ala Phe Phe Leu Gly Lys Glu Arg Val Lys Gly Ser Leu
625 630 635 640
Asp Gln Leu Asp Glu Val Ala Ala Leu Ile Ala Ala Thr Val His Asp
645 650 655
Val Asp His Pro Gly Arg Thr Asn Ser Phe Leu Cys Asn Ala Gly Ser
660 665 670
Glu Leu Ala Val Leu Tyr Asn Asp Thr Ala Val Leu Glu Ser His His
675 680 685
Thr Ala Leu Ala Phe Gln Leu Thr Val Lys Asp Thr Lys Cys Asn Ile
690 695 700
Phe Lys Asn Ile Asp Arg Asn His Tyr Arg Thr Leu Arg Gln Ala Ile
705 710 715 720
Ile Asp Met Val Leu Ala Thr Glu Met Thr Lys His Phe Glu His Val
725 730 735
Asn Lys Phe Val Asn Ser Ile Asn Lys Pro Met Ala Ala Glu Ile Glu
740 745 750
Gly Ser Asp Cys Glu Cys Asn Pro Ala Gly Lys Asn Phe Pro Glu Asn
755 760 765
Gln Ile Leu Ile Lys Arg Met Met Ile Lys Cys Ala Asp Val Ala Asn
770 775 780
Pro Cys Arg Pro Leu Asp Leu Cys Ile Glu Trp Ala Gly Arg Ile Ser
785 790 795 800
Glu Glu Tyr Phe Ala Gln Thr Asp Glu Glu Lys Arg Gln Gly Leu Pro
805 810 815
Val Val Met Pro Val Phe Asp Arg Asn Thr Cys Ser Ile Pro Lys Ser
820 825 830
Gln Ile Ser Phe Ile Asp Tyr Phe Ile Thr Asp Met Phe Asp Ala Trp
835 840 845
Asp Ala Phe Ala His Leu Pro Ala Leu Met Gln His Leu Ala Asp Asn
850 855 860
Tyr Lys His Trp Lys Thr Leu Asp Asp Leu Lys Cys Lys Ser Leu Arg
865 870 875 880
Leu Pro Ser Asp Ser
885
<210>195
<211>427
<212>PRT
<213>人
<400>195
Met Phe Phe Thr Cys Gly Pro Asn Glu Ala Met Val Val Ser Gly Phe
1 5 10 15
Cys Arg Ser Pro Pro Val Met Val Ala Gly Gly Arg Val Phe Val Leu
20 25 30
Pro Cys Ile Gln Gln Ile Gln Arg Ile Ser Leu Asn Thr Leu Thr Leu
35 40 45
Asn Val Lys Ser Glu Lys Val Tyr Thr Arg His Gly Val Pro Ile Ser
50 55 60
Val Thr Gly Ile Ala Gln Val Lys Ile Gln Gly Gln Asn Lys Glu Met
65 70 75 80
Leu Ala Ala Ala Cys Gln Met Phe Leu Gly Lys Thr Glu Ala Glu Ile
85 90 95
Ala His Ile Ala Leu Glu Thr Leu Glu Gly His Gln Arg Ala Ile Met
100 105 110
Ala His Met Thr Val Glu Glu Ile Tyr Lys Asp Arg Gln Lys Phe Ser
115 120 125
Glu Gln Val Phe Lys Val Ala Ser Ser Asp Leu Val Asn Met Gly Ile
130 135 140
Ser Val Val Ser Tyr Thr Leu Lys Asp Ile His Asp Asp Gln Asp Tyr
145 150 155 160
Leu His Ser Leu Gly Lys Ala Arg Thr Ala Gln Val Gln Lys Asp Ala
165 170 175
Arg Ile Gly Glu Ala Glu Ala Lys Arg Asp Ala Gly Ile Arg Glu Ala
180 185 190
Lys Ala Lys Gln Glu Lys Val Ser Ala Gln Tyr Leu Ser Glu Ile Glu
195 200 205
Met Ala Lys Ala Gln Arg Asp Tyr Glu Leu Lys Lys Ala Ala Tyr Asp
210 215 220
Ile Glu Val Asn Thr Arg Arg Ala Gln Ala Asp Leu Ala Tyr Gln Leu
225 230 235 240
Gln Val Ala Lys Thr Lys Gln Gln Ile Glu Glu Gln Arg Val Gln Val
245 250 255
Gln Val Val Glu Arg Ala Gln Gln Val Ala Val Gln Glu Gln Glu Ile
260 265 270
Ala Arg Arg Glu Lys Glu Leu Glu Ala Arg Val Arg Lys Pro Ala Glu
275 280 285
Ala Glu Arg Tyr Lys Leu Glu Arg Leu Ala Glu Ala Glu Lys Ser Gln
290 295 300
Leu Ile Met Gln Ala Glu Ala Glu Ala Ala Ser Val Arg Met Arg Gly
305 310 315 320
Glu Ala Glu Ala Phe Ala Ile Gly Ala Arg Ala Arg Ala Glu Ala Glu
325 330 335
Gln Met Ala Lys Lys Ala Glu Ala Phe Gln Leu Tyr Gln Glu Ala Ala
340 345 350
Gln Leu Asp Met Leu Leu Glu Lys Leu Pro Gln Val Ala Glu Glu Ile
355 360 365
Ser Gly Pro Leu Thr Ser Ala Asn Lys Ile Thr Leu Val Ser Ser Gly
370 375 380
Ser Gly Thr Met Gly Ala Ala Lys Val Thr Gly Glu Val Leu Asp Ile
385 390 395 400
Leu Thr Arg Leu Pro Glu Ser Val Glu Arg Leu Thr Gly Val Ser Ile
405 410 415
Ser Gln Val Asn His Lys Pro Leu Arg Thr Ala
420 425
<210>196
<211>495
<212>PRT
<213>人
<400>196
Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly
1 5 10 15
Met Leu Val Ala Ser Cys Leu Gly Arg Leu Ser Trp Tyr Asp Pro Asp
20 25 30
Phe Gln Ala Arg Leu Thr Arg Ser Asn Ser Lys Cys Gln Gly Gln Leu
35 40 45
Glu Val Tyr Leu Lys Asp Gly Trp His Met Val Cys Ser Gln Ser Trp
50 55 60
Gly Arg Ser Ser Lys Gln Trp Glu Asp Pro Ser Gln Ala Ser Lys Val
65 70 75 80
Cys Gln Arg Leu Asn Cys Gly Val Pro Leu Ser Leu Gly Pro Phe Leu
85 90 95
Val Thr Tyr Thr Pro Gln Ser Ser Ile Ile Cys Tyr Gly Gln Leu Gly
100 105 110
Ser Phe Ser Asn Cys Ser His Ser Arg Asn Asp Met Cys His Ser Leu
115 120 125
Gly Leu Thr Cys Leu Glu Pro Gln Lys Thr Thr Pro Pro Thr Thr Arg
130 135 140
Pro Pro Pro Thr Thr Thr Pro Glu Pro Thr Ala Pro Pro Arg Leu Gln
145 150 155 160
Leu Val Ala Gln Ser Gly Gly Gln His Cys Ala Gly Val Val Glu Phe
165 170 175
Tyr Ser Gly Ser Leu Gly Gly Thr Ile Ser Tyr Glu Ala Gln Asp Lys
180 185 190
Thr Gln Asp Leu Glu Asn Phe Leu Cys Asn Asn Leu Gln Cys Gly Ser
195 200 205
Phe Leu Lys His Leu Pro Glu Thr Glu Ala Gly Arg Ala Gln Asp Pro
210 215 220
Gly Glu Pro Arg Glu His Gln Pro Leu Pro Ile Gln Trp Lys Ile Gln
225 230 235 240
Asn Ser Ser Cys Thr Ser Leu Glu His Cys Phe Arg Lys Ile Lys Pro
245 250 255
Gln Lys Ser Gly Arg Val Leu Ala Leu Leu Cys Ser Gly Phe Gln Pro
260 265 270
Lys Val Gln Ser Arg Leu Val Gly Gly Ser Ser Ile Cys Glu Gly Thr
275 280 285
Val Glu Val Arg Gln Gly Ala Gln Trp Ala Ala Leu Cys Asp Ser Ser
290 295 300
Ser Ala Arg Ser Ser Leu Arg Trp Glu Glu Val Cys Arg Glu Gln Gln
305 310 315 320
Cys Gly Ser Val Asn Ser Tyr Arg Val Leu Asp Ala Gly Asp Pro Thr
325 330 335
Ser Arg Gly Leu Phe Cys Pro His Gln Lys Leu Ser Gln Cys His Glu
340 345 350
Leu Trp Glu Arg Asn Ser Tyr Cys Lys Lys Val Phe Val Thr Cys Gln
355 360 365
Asp Pro Asn Pro Ala Gly Leu Ala Ala Gly Thr Val Ala Ser Ile Ile
370 375 380
Leu Ala Leu Val Leu Leu Val Val Leu Leu Val Val Cys Gly Pro Leu
385 390 395 400
Ala Tyr Lys Lys Leu Val Lys Lys Phe Arg Gln Lys Lys Gln Arg Gln
405 410 415
Trp Ile Gly Pro Thr Gly Met Asn Gln Asn Met Ser Phe His Arg Asn
420 425 430
His Thr Ala Thr Val Arg Ser His Ala Glu Asn Pro Thr Ala Ser His
435 440 445
Val Asp Asn Glu Tyr Ser Gln Pro Pro Arg Asn Sar Arg Leu Ser Ala
450 455 460
Tyr Pro Ala Leu Glu Gly Val Leu His Arg Ser Ser Met Gln Pro Asp
465 470 475 480
Asn Ser Ser Asp Ser Asp Tyr Asp Leu His Gly Ala Gln Arg Leu
485 490 495
<210>197
<211>540
<212>PRT
<213>人
<400>197
Met Gly Thr Thr Ala Arg Ala Ala Leu Val Leu Thr Tyr Leu Ala yal
1 5 10 15
Ala Ser Ala Ala Ser Glu Gly Gly Phe Thr Ala Thr Gly Gln Arg Gln
20 25 30
Leu Arg Pro Glu His Phe Gln Glu Val Gly Tyr Ala Ala Pro Pro Ser
35 40 45
Pro Pro Leu Ser Arg Ser Leu Pro Met Asp His Pro Asp Ser Ser Gln
50 55 60
His Gly Pro Pro Phe Glu Gly Gln Ser Gln Val Gln Pro Pro Pro Ser
65 70 75 80
Gln Glu Ala Thr Pro Leu Gln Gln Glu Lys Leu Leu Pro Ala Gln Leu
85 90 95
Pro Ala Glu Lys Glu Val Gly Pro Pro Leu Pro Gln Glu Ala Val Pro
100 105 110
Leu Gln Lys Glu Leu Pro Ser Leu Gln His Pro Asn Glu Gln Lys Glu
115 120 125
Gly Thr Pro Ala Pro Phe Gly Asp Gln Ser His Pro Glu Pro Glu Ser
130 135 140
Trp Asn Ala Ala Gln His Cys Gln Gln Asp Arg Ser Gln Gly Gly Trp
145 150 155 160
Gly His Arg Leu Asp Gly Phe Pro Pro Gly Arg Pro Ser Pro Asp Asn
165 170 175
Leu Asn Gln Ile Cys Leu Pro Asn Arg Gln His Val Val Tyr Gly Pro
180 185 190
Trp Asn Leu Pro Gln Ser Ser Tyr Ser His Leu Thr Arg Gln Gly Glu
195 200 205
Thr Leu Asn Phe Leu Glu Ile Gly Tyr Ser Arg Cys Cys His Cys Arg
210 215 220
Ser His Thr Asn Arg Leu Glu Cys Ala Lys Leu Val Trp Glu Glu Ala
225 230 235 240
Met Ser Arg Phe Cys Glu Ala Glu Phe Ser Val Lys Thr Arg Pro His
245 250 255
Trp Cys Cys Thr Arg Gln Gly Glu Ala Arg Phe Ser Cys Phe Gln Glu
260 265 270
Glu Ala Pro Gln Pro His Tyr Gln Leu Arg Ala Cys Pro Ser His Gln
275 280 285
Pro Asp Ile Ser Ser Gly Leu Glu Leu Pro Phe Pro Pro Gly Val Pro
290 295 300
Thr Leu Asp Asn Ile Lys Asn Ile Cys His Leu Arg Arg Phe Arg Ser
305 310 315 320
Val Pro Arg Asn Leu Pro Ala Thr Asp Pro Leu Gln Arg Glu Leu Leu
325 330 335
Ala Leu Ile Gln Leu Glu Arg Glu Phe Gln Arg Cys Cys Arg Gln Gly
340 345 350
Asn Asn His Thr Cys Thr Trp Lys Ala Trp Glu Asp Thr Leu Asp Lys
355 360 365
Tyr Cys Asp Arg Glu Tyr Ala Val Lys Thr His His His Leu Cys Cys
370 375 380
Arg His Pro Pro Ser Pro Thr Arg Asp Glu Cys Phe Ala Arg Arg Ala
385 390 395 400
Pro Tyr Pro Asn Tyr Asp Arg Asp Ile Leu Thr Ile Asp Ile Gly Arg
405 410 415
Val Thr Pro Asn Leu Met Gly His Leu Cys Gly Asn Gln Arg Val Leu
420 425 430
Thr Lys His Lys His Ile Pro Gly Leu Ile His Asn Met Thr Ala Arg
435 440 445
Cys Cys Asp Leu Pro Phe Pro Glu Gln Ala Cys Cys Ala Glu Glu Glu
450 455 460
Lys Leu Thr Phe Ile Asn Asp Leu Cys Gly Pro Arg Arg Asn Ile Trp
465 470 475 480
Arg Asp Pro Ala Leu Cys Cys Tyr Leu Ser Pro Gly Asp Glu Gln Val
485 490 495
Asn Cys Phe Asn Ile Asn Tyr Leu Arg Asn Val Ala Leu Val Ser Gly
500 505 510
Asp Thr Glu Asn Ala Lys Gly Gln Gly Glu Gln Gly Ser Thr Gly Gly
515 520 525
Thr Asn Ile Ser Ser Thr Ser Glu Pro Lys Glu Glu
530 535 540
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