人类肝脏中表达的表达序列标签I组
阅读：225发布：2020-05-11
专利汇可以提供人类肝脏中表达的表达序列标签I组专利检索，专利查询，专利分析的服务。并且本 发明 公开了一类在人类肝脏中表达的表达序列标签的序列。利用本发明的在人类肝脏中表达的表达序列标签，可以方便的寻找出在人类肝脏中表达的相关基因，从而在研究肝脏 疾病 的致病机理以及开发 治疗 肝脏疾病的药物中发挥重要作用。，下面是人类肝脏中表达的表达序列标签I组专利的具体信息内容。
1.一类在人类肝脏中表达的表达序列标签的序列，其特征在于，它包括：
(a)SEQ ID No.1～SEQ ID No.58所示的序列；
(b)SEQ ID No.1～SEQ ID No.58所示的序列中每条序列的互补序列；
(c)与SEQ ID No.1～SEQ ID No.58所示的序列中每条序列有至少70％同源性的 序列；
(d)上述(a)～(c)中一条或数条的组合。
2.如权利要求1所述的表达序列标签的序列，其特征在于，所述序列包括具有SEQ ID No.1～SEQ ID No.58所示的序列。
3.一种探针分子，其特征在于，所述的探针分子含有权利要求1中所述的序列中约 8-100个连续的核苷酸。
技术领域
本发明涉及生物技术领域，尤其涉及一类在人类肝脏中表达的表达序列标签。
背景技术
肝脏是人体内最大的消化腺。也是体内新陈代谢的中心站。据估计，在肝脏中发 生的化学反应有500种以上，实验证明，动物在完全摘除肝脏后即使给予相应的治疗， 最多也只能生存50多个小时。这说明肝脏是维持生命活动的一个必不可少的重要器 官。肝脏的血流量极为丰富，约占心输出量的1/4。每分钟进入肝脏的血流量为 1000-1200ml。肝脏的主要功能是进行糖的分解、贮存糖原；参与蛋白质、脂肪、维 生素、激素的代谢；解毒；分泌胆汁；吞噬、防御机能；制造凝血因子；调节血容量 及水电解质平衡；产生热量等。在胚胎时期肝脏还有造血功能。
肝脏疫病分为肝炎、肝硬化、脂肪肝、肝癌等。现代医学实验证明，肝病病毒侵 入人体后，并不直接引起肝细胞的损害，只是在肝细胞内吸收营养赖以生存，并在肝 细胞内复制、繁殖。其复制病毒的“零部件”如表面抗原(HBsAg)、e抗原(HBeAg) 释放在肝细胞膜上，引起人体免疫系统对这些抗原物质产生免疫反应，这种反应造成 肝细胞的损伤、坏死。免疫反应的强弱决定于肝脏受损程度及临床症状轻重。这场由 病毒引发的、免疫系统对肝细胞的战争，使大约25％的患者的肝脏成为战火连绵的战 场，肝脏的损伤由此加重。肝病的危害绝不仅仅限于肝脏本身，它还可以引起其它多 种疾病。常见的有：(1)糖尿病；(2)胰腺炎；(3)胆道感染；(4)功能性肾衰竭； (5)胆汗性肾病；(6)肾小球肾炎；(7)肾小管酸中毒；(8)溶血性贫血；(9)再 生障碍性贫血；(10)心肌炎和心包炎；(11)结节性动脉炎；(12)消化性溃疡；(13) 自发性腹膜炎；(14)性激素代谢紊乱；(15)甲状腺功能改变；(16)肝性骨病，等 等。肝病不仅对患者的身体甚至生命造成危害，而且对患者心理上的打击也是十分沉 重的。无论是肝病患者还是病毒携带者，在生活、社交、求职、升学等方面都会受到 严重影响。
生物基因组中可转录表达的序列(即基因)仅占总序列的3-5％，对这部分序列 进行测定，将直接导致新基因的发现，并获取基因组中与产业化关系最为密切的信息。 20世纪80年代，高通量的自动测序的出现，使从质粒互补脱氧核糖核酸 (Complementary DNA，简称cDNA)文库随机选取许多cDNA克隆和决定来自非载体两 端的几百个碱基的DNA序列成为可能。这些短的DNA序列叫做“表达序列标签” (Expressed Sequence Tags，简称ESTs)。表达序列标签的概念最早是由Adams等在 1992年提出来的(Nature，355，642-644)。1992年Sikela和Matsubara(Sikela， et al.Nucleic Acids Res.19，1837-1843；Matsubara，et al.Nature Genetics. 2，173-179)针对获得大量信使核糖核酸(mRNA)序列的迫切需要，提出大规模互补 脱氧核糖核酸(cDNA)测序的研究战略。随后Venter创立了大规模表达序列标签技 术。其基本特征就是从以质粒为载体，构建完成的目的组织互补脱氧核糖核酸 (Complementary DNA，简称cDNA)文库中，随机选择许多cDNA克隆，利用质粒上携 带的通用引物对cDNA两端进行一轮脱氧核糖核酸序列测定，所获得的来自3’端或 5’端的几百个碱基的非载体短脱氧核糖核酸(DNA)序列。简而言之，表达序列标签 是来自表达基因片段3’端或5’端的短脱氧核糖核酸序列，代表一个表达基因的部 分转录片段。
表达序列标签可用于新基因克隆、人类基因组图谱绘制、基因组序列编码区的确 定等。如果一个表达序列标签在基因组中只出现一次，那么它可以作为序列标签位点 (STS)。由表达序列标签构建的物理图谱叫表达图或转录图(expression or transcript map)。利用表达序列标签进行基因图制作，可以加快序列标签位点的制 作和新基因的染色体定位。表达序列标签可以作为基因特异性探针，对组织特异性基 因表达的研究具有重要的作用。表达序列标签还可以进行新基因的遗传进化关系分 析。表达序列标签可以对所有动植物的基因作为一种数据库，通过不同的序列比较可 以获得保守序列片段，从而获得基因的遗传进化图谱。正因为表达序列标签具有如此 的优越性，因此表达序列标签测序已经成为许多基因组研究机构的工作重点。
表达序列标签(EST)是一种快速有效揭示基因组容量的方法。ESTs在新基因的 发现、基因作图和基因组序列编码区域的确定等方面起到重要作用。EST不仅为基因 组遗传图谱的构建提供了大量的分子标记，而且来自不同组织和器官的EST也为基因 的功能研究提供了有价值的信息。此外，EST计划还为基因的鉴定提供了候选基因 (candidantes)。
在本发明之前，还没有出现涉及本发明的一类在人类肝脏中表达的表达序列标签 的公开报道。
肝脏疫病分为肝炎、肝硬化、脂肪肝、肝癌等。现代医学实验证明，肝病病毒侵 入人体后，并不直接引起肝细胞的损害，只是在肝细胞内吸收营养赖以生存，并在肝 细胞内复制、繁殖。其复制病毒的“零部件”如表面抗原(HBsAg)、e抗原(HBeAg) 释放在肝细胞膜上，引起人体免疫系统对这些抗原物质产生免疫反应，这种反应造成 肝细胞的损伤、坏死。免疫反应的强弱决定于肝脏受损程度及临床症状轻重。这场由 病毒引发的、免疫系统对肝细胞的战争，使大约25％的患者的肝脏成为战火连绵的战 场，肝脏的损伤由此加重。肝病的危害绝不仅仅限于肝脏本身，它还可以引起其它多 种疾病。常见的有：(1)糖尿病；(2)胰腺炎；(3)胆道感染；(4)功能性肾衰竭； (5)胆汗性肾病；(6)肾小球肾炎；(7)肾小管酸中毒；(8)溶血性贫血；(9)再 生障碍性贫血；(10)心肌炎和心包炎；(11)结节性动脉炎；(12)消化性溃疡；(13) 自发性腹膜炎；(14)性激素代谢紊乱；(15)甲状腺功能改变；(16)肝性骨病，等 等。肝病不仅对患者的身体甚至生命造成危害，而且对患者心理上的打击也是十分沉 重的。无论是肝病患者还是病毒携带者，在生活、社交、求职、升学等方面都会受到 严重影响。
生物基因组中可转录表达的序列(即基因)仅占总序列的3-5％，对这部分序列 进行测定，将直接导致新基因的发现，并获取基因组中与产业化关系最为密切的信息。 20世纪80年代，高通量的自动测序的出现，使从质粒互补脱氧核糖核酸 (Complementary DNA，简称cDNA)文库随机选取许多cDNA克隆和决定来自非载体两 端的几百个碱基的DNA序列成为可能。这些短的DNA序列叫做“表达序列标签” (Expressed Sequence Tags，简称ESTs)。表达序列标签的概念最早是由Adams等在 1992年提出来的(Nature，355，642-644)。1992年Sikela和Matsubara(Sikela， et al.Nucleic Acids Res.19，1837-1843；Matsubara，et al.Nature Genetics. 2，173-179)针对获得大量信使核糖核酸(mRNA)序列的迫切需要，提出大规模互补 脱氧核糖核酸(cDNA)测序的研究战略。随后Venter创立了大规模表达序列标签技 术。其基本特征就是从以质粒为载体，构建完成的目的组织互补脱氧核糖核酸 (Complementary DNA，简称cDNA)文库中，随机选择许多cDNA克隆，利用质粒上携 带的通用引物对cDNA两端进行一轮脱氧核糖核酸序列测定，所获得的来自3’端或 5’端的几百个碱基的非载体短脱氧核糖核酸(DNA)序列。简而言之，表达序列标签 是来自表达基因片段3’端或5’端的短脱氧核糖核酸序列，代表一个表达基因的部 分转录片段。
表达序列标签可用于新基因克隆、人类基因组图谱绘制、基因组序列编码区的确 定等。如果一个表达序列标签在基因组中只出现一次，那么它可以作为序列标签位点 (STS)。由表达序列标签构建的物理图谱叫表达图或转录图(expression or transcript map)。利用表达序列标签进行基因图制作，可以加快序列标签位点的制 作和新基因的染色体定位。表达序列标签可以作为基因特异性探针，对组织特异性基 因表达的研究具有重要的作用。表达序列标签还可以进行新基因的遗传进化关系分 析。表达序列标签可以对所有动植物的基因作为一种数据库，通过不同的序列比较可 以获得保守序列片段，从而获得基因的遗传进化图谱。正因为表达序列标签具有如此 的优越性，因此表达序列标签测序已经成为许多基因组研究机构的工作重点。
表达序列标签(EST)是一种快速有效揭示基因组容量的方法。ESTs在新基因的 发现、基因作图和基因组序列编码区域的确定等方面起到重要作用。EST不仅为基因 组遗传图谱的构建提供了大量的分子标记，而且来自不同组织和器官的EST也为基因 的功能研究提供了有价值的信息。此外，EST计划还为基因的鉴定提供了候选基因 (candidantes)。
在本发明之前，还没有出现涉及本发明的一类在人类肝脏中表达的表达序列标签 的公开报道。
发明内容
本发明要解决的技术问题是提供一类在人类肝脏中表达的表达序列标签。
为了解决上述技术问题，本发明通过如下技术方案实现：
在本发明的一个方面，提供了一类在人类肝脏中表达的表达序列标签的序列，其 包括：
(a)SEQ ID No.1～SEQ ID No.58所示的序列；
(b)SEQ ID No.1～SEQ ID No.58所示的序列中每条序列的互补序列；
(c)与SEQ ID No.1～SEQ ID No.58所示的序列中每条序列有至少70％同源性的 序列；
(d)上述(a)～(c)中一条或数条的组合。
较佳地，所述序列包括具有SEQ ID No.1～SEQ ID No.58所示的序列。
本发明还提供了一种探针分子，所述的探针分子含有上述序列中约8-100个连续 的核苷酸。
由本发明的一类在人类肝脏中表达的表达序列标签，可以方便的寻找出在人类肝 脏中特异表达的相关基因，从而在研究肝脏疾病的致病机理以及开发治疗肝脏疾病的 药物中发挥重要作用。
为了解决上述技术问题，本发明通过如下技术方案实现：
在本发明的一个方面，提供了一类在人类肝脏中表达的表达序列标签的序列，其 包括：
(a)SEQ ID No.1～SEQ ID No.58所示的序列；
(b)SEQ ID No.1～SEQ ID No.58所示的序列中每条序列的互补序列；
(c)与SEQ ID No.1～SEQ ID No.58所示的序列中每条序列有至少70％同源性的 序列；
(d)上述(a)～(c)中一条或数条的组合。
较佳地，所述序列包括具有SEQ ID No.1～SEQ ID No.58所示的序列。
本发明还提供了一种探针分子，所述的探针分子含有上述序列中约8-100个连续 的核苷酸。
由本发明的一类在人类肝脏中表达的表达序列标签，可以方便的寻找出在人类肝 脏中特异表达的相关基因，从而在研究肝脏疾病的致病机理以及开发治疗肝脏疾病的 药物中发挥重要作用。
具体实施方式
下面结合具体实施例，进一步阐述本发明。应理解，这些实施例仅用于说明本发 明而不是限制本发明的范围。下列实施例中未注明具体条件的实验方法，通常按照常 规条件如Sambrook等人，分子克隆：实验室手册(New York：Cold Spring Harbor Laboratory Press，1989)中所述的条件，或按照制造厂商所建议的条件。
实施例1
人肝脏组织的mRNA的分离
组织分离(Tissue isolation)：肝脏来源于5个成年男性，在肝脏切除手术后， 将肝脏组织立即置于液氮中冷冻保存。
mRNA的分离(mRNA isolation)：取出肝脏组织，用研钵研碎，加入盛有裂解液 的50ml管，充分振荡后，再移入玻璃匀浆器内，匀浆后移至50ml新管，抽提总RNA (TRIzol Reagents，Gibco，NY，USA)。用甲醛变性胶电泳鉴定总RNA质量。用带Oligo d(T)的纤维素柱分离总RNA中的mRNA，定量。
实施例2
cDNA文库的构建(Constuction of cDNA library)
以mRNA为模板，合成双链cDNA。补平末端后，加含EcoRI切点的接头。磷酸化 EcoRI末端后，用XhoI限制性内切酶消化1.5小时，再进行片断分离。过柱筛选长 度＞500bp的片段，用酚-氯仿抽提，乙醇沉淀，无菌水溶解，连接至Uni-ZAP XR载体 (Strategene，CA9203，USA)，以ZAP-cDNA Gigapack III Gold Cloning Kit (Strategene，CA9203，USA)进行包装，宿主菌使用XL 1 Blue MRF’ (Strategene，CA9203，USA)细菌。涂板并测定滴度。
实施例3
测序及数据库建立(Seqencing and Database Constructing)
挑选文库中有外源片段插入的克隆，扩增后抽提质粒(Qiagen Germany)，用T3 和T7作为3’和5’端的通用引物，采用终止物荧光标记 (Big-Dye，Perkin-Elmer，USA)的方法，在ABI 377测序仪(Perkin-Elmer，USA)上 进行EST大规模测序。测序结果用FACTURA软件去除载体序列，传输到SUN Ultra 450
Server上进行下一步的处理。所有的序列信息再用GCG软件包(Wisconsin group，USA) 中的BLAST和FASTA软件搜索已有的数据库(Genebank+EMBL)，将无同源性或同源性 低于95％的序列视为新基因建立数据库。
实施例4
基因的全长克隆(Cloning of Full-length cDNA)
在得到的新基因片段序列信息基础上，进行cDNA全长克隆，分两阶段进行：
(1)“电子克隆”(Electronic Cloning)
以新基因片段序列作为探针搜寻dbEST数据库，将重叠序列＞50bp，同源性在98％ 以上的表达序列标签(Expressed Sequence Tag，简称“EST”)序列认为同一序列 (Consensus Sequence)，取出并用AUTOASSEMBLER软件进行连接，部分EST可以延 伸探针序列。再用STRIDER软件分析被延伸的序列是否具有完整的开放阅读框架(Open Reading Frame，ORF)，用BLAST搜寻Genbank或SwissProt以确定该序列的核苷酸 和氨基酸水平上是否与其他物种有同源性，以帮助判别所得到的基因全长完整性如 何。通过电子克隆的方法，通常可获取人肝脏相关基因的全长序列。
(2)cDNA末端快速扩增(Rapid Amplification of cDNA Ends，RACE)
如果通过“电子克隆”方法仍未得到完整的cDNA全长，则在已有序列5’或3’ 端设计引物，在人类肝脏Marathon-Ready cDNA文库(Clontech Lab，Inc，USA)中 进行长距离PCR反应。然后对PCR产物克隆、测序。用AUTOASSEMBLER及STRIDER软 件分析被延长的序列有无完整的ORF，如无，重复上述过程直至获得全长。
(3)RT-PCR
对于5’和3’端的已知的序列，如果中间有一段间隙(gap)无法从已有的公共 数据库或自身数据库获得，可考虑采用RT-PCR的方法。在序列5’端设计引物，3’ 端引物采用Oligo-dT，在肝脏总RNA库中进行扩增。然后对产物进行克隆、测序。最 后拼接便获得全长。
通过组合使用上述3种方法，可获得人肝脏相关蛋白的全长编码序列。
序列表
<110>上海人类基因组研究中心
<120>人类肝脏中表达的表达序列标签I组
<130>NP-10041
<160>58
<210>1
<211>563
<212>DNA
<213>Homo sapiens
<400>1
1 taacaagggg gcagtcattt aatgcagaaa tccagttaac ataaagagac agaggttgaa
61 caacaggtct tcaaacaata ctgcatagtg tcacgagtta gctcttaagc acgtttgatc
121 tgtttatctt atgatttcga ttccagtaca aagacagaga agagacttaa aaaaaaaaaa
181 acaataaggc aacagaagaa gaatcttcct gtgacaagga acgtccacaa ataatgcaca
241 aatatttggt gctgacacaa taagacacca tcaggacaag ttctgaagat gctgcattaa
301 aatttaacaa gcatgataca atgacaagaa aattatactc gctttgttac gaatcctttt
361 gcaagtagaa atgactctcg ggtaattgtt acatacaaac tttctgaaat aaatggaaat
421 catacaaatt tttccattgc agtttctctt tctctacacc tagaaatgtc catggcactg
481 ctccctattc tcacagtcac gcataatagc cttaaagcct tgaatccaca gtggcttgtc
541 cttagaaggt ggaggttgct gat
<210>2
<211>659
<212>DNA
<213>Homo sapiens
<400>2
1 acattttaga gttgtttact tttattaata aaaagttaga tcacttatat atatatacat
61 tgaaaaaaac tattattgtc cctttcctgg tgaaaaggag tatacacaac agacctttgt
121 gatattctgc aacaatgacc catattgctg tggaattctc actttttagt agaaccttta
181 aaaactcaag tgagctgtac aacgccccga ttgctttaac tccagtgaac cacggaggta
241 taaagacgct agagttcttt gtaattcttc agtgccaaaa ataataaagt tggaaacttg
301 gattcctgtt tgactctact gtattaagtg atcagaataa aattactgta aggctaatct
361 tcaaccactt catggttttc attcttgctt tctatagtga acatctggtt gtttccactt
421 ggctctaaac ccctttcctt ttgggattca gcccactact catccatgtg attctgacag
481 gaggttagca atgacagtgc agatagatag cccaggcctg gccaaagatc acaggcccca
541 tcccctcttc cacagggact gggtccatgc aagggcaggt gattctgggg aagaccagag
601 tccttttata ganttgattg tggacctgaa aaggaagtnt cccctccctt tgancatgg
<210>3
<211>604
<212>DNA
<213>Homo sapiens
<400>3
1 tnataaacat atngaaaact ttantagaaa tatanagaaa aanaaataac ttgcctgnga
61 ggtttcctgt cccttcagga tggatganca acagatgggg cacctaggtc cagtggggct
121 gctcccgatc tactgtttct tcctccagga gcaaggcatc tagctccttc cagccgctnc
181 tgagcagggg gcccacatca gggctggggg ccacattggg aggaacagtc ctgccccctg
241 cagcccggac cccacggacg gtcttcgtga tcgaggaagg ctgctgtccc gaaattccac
301 agcccgccgg agcttccttg agctggtgaa aatcagagtc ccattgcgct cccggggttc
361 ctcaaagatg gtctcaaagg tcctcctggt tgtggggtga ttggtaattc ttggttggtg
421 taaatttctt ccaagctgaa ctccttcttg gttcaacctg attgggtcga ggcagtccca
481 ttggtgtaan gtttaagctg aggacgggct ggtgttctgc ggnattctga atcgngaacc
541 tttcccatgg tcttggtctc aaggttngaa agcacctggg tcncttgaag gctcttggct
601 cctt
<210>4
<211>629
<212>DNA
<213>Homo sapiens
<400>4
1 aacaaattgt attattacac attcctagtt gctgcttgta atagaacaga tttcaatctc
61 agaaatgttt atctgagaga catagatcag gtttacaagg acaagaggtc aaagtcatgc
121 cacagacgat ccacaccacc tatgtatgca ctctctctct tgcacacaca cacgcacacg
181 cgcacacaca cgctgagtct catgtgctta cctcgtctga ctgccgctgg tgttatatgt
241 agcttccatg cctggaagag gcacatatgg taacatggtg tggctaaagt aaagcaaaag
301 tacaaaagca ataggtaagg gcagtgggat aacaggaaag gttttgatgt tattgtgggt
361 attagcacat gatagcccca agaagacaag aaatgtcagt tactcagaaa gaggaaagct
421 ttccaaccag gagagttata tttatgtgcc ctcactggaa tggaggcaga ctgacaggaa
481 gattattttc caacttgaat ggaaagaagg cagagacaga aagaaagaac agtggctggg
541 caagtggctg atgccnataa tcccagcact tgggaggctg aagttggcaa tcgcttcagc
601 ctggagttca gacccagctt ggcacatgg
<210>5
<211>716
<212>DNA
<213>Homo sapiens
<400>5
1 agatggagtc tcgctctgtt gcccaggctg gaatgcagtg gtgcgatctc ggctcactgc
61 aacctcctct tcctgggttc aggcaattct cctgcttcag cctcccaagt agctgggact
121 acaggcgcat nanccacgcc gggctaattt ttgtattttt agtagagact gggtttcacc
181 gtgttagcca ggatggtctc aatctcctga cctcgtgatc cgcccgcctc agcctcccaa
241 agtgctgggg ttacaggcgt gacacncgtg cccggctgag aacattttac atatatgcga
301 aatagctacc cagtcctgat tcgactagag cactgagtga cacacattaa atgttaagtt
361 tgaaaagact gtaaaacatt cacatatgac agctcttagt gaagtaagag cctctcatat
421 tncctaattg tttgaaacat tccaggagag ctaggttccc gtattctcct ctagaagtgt
481 gtatagggct ccctcccttg tttggngata ttnttgatat ttcctccgaa tgatgtttac
541 ttgactctgg ggcaagctga gcttttccac agatttagtt acttcttcac taactcactc
601 ntcagcaagg ggaaactccg atgaatnagt tcngtattgg naactggtag gttgttanca
661 attatttcaa gttccgatgt atccgaatgg gnaagtgagg nccgtattgg aattct
<210>6
<211>392
<212>DNA
<213>Homo sapiens
<400>6
1 tttgcaggtg actacgcatc atggtaagtt ttatacccta gtcaaaatga aaaatagcaa
61 aaaccgcact gtaaaaaaaa aaaaaaaatt ggtttccttt agtagatagt atttcaaccc
121 atcatattct tattataaat aaacagaaca atcttaagtt gacagatatc aaagagacct
181 tgatctgatt ttggtgccaa gtgaggtctt aattcctcat tcctgcctta agtgcttggt
241 gtcatacagt gggtggtaca aagctgtttt atgcctaata ttgctaaatg ggacccttct
301 aattgatttg aaagacatta taacatattg tccagacttt aagacttaaa gagtaggaaa
361 tactactttt agtggctaaa tttattcatt tt
<210>7
<211>488
<212>DNA
<213>Homo sapiens
<400>7
1 gatcccagca gtgtccagaa gaagaccaag gacagaacag agactaggtt tggtgagatg
61 ggacagattt tgggaaagat catgatgagc catcaaccgc agccccagga agagcggacg
121 ccccagcggc gcctcagggt accccctcca ggaggtggtg gatgatgaag tgttgggacc
181 atcaggtgag gggactggag aaagaagagg tggcatagga ttgactaaga tgaaggaagg
241 gggccaggcg tggtggctca cccctgtaac cccaacactt tgggaggctg aggcgggcag
301 atcacctgag gtcaggaatt caagaccagc ctggccaaca tggtgaaacc ccatctctac
361 taaaagtaca aaaattagcc aggcggtagt ggtgtgtgcc tataatccca gctacttggg
421 aggctaagac aggagaatca cttgagcctg ggaggaagag gttgcagtga gccgagatcg
481 tgctactg
<210>8
<211>569
<212>DNA
<213>Homo sapiens
<400>8
1 gggtgaaatg agttactaaa tgtagcattt atttataagg aatgcattgt gaatagtttc
61 tcagttttca ttatggaaag atgatgattt cagcccacat tcagtgtatg tttctaaata
121 acacaatcga caggactgtc tgttcagtac aatggaggac agctttttca gggcaaatgg
181 gatttcttga taatgctaaa tctgtcttgt cagctgaatt tcttgggctt tatgtggcag
241 tgtggtaaaa atatatgatc agatttcact gttaagaaaa ttctttcagc aatacatgta
301 gagtcaagtt tcttgcatgg ataactgaac atgtgggtta tgagatttta aaaaatgtct
361 cgtgacaaac tttacggaaa tgcaacaatc tggacatcta gttttgtctg agagtggcgt
421 ggatatgaag aactgtgctg ttggtgctga tgccacacta agttttggca gtcacactct
481 tggttcttca tatttgagga gatgggatgg tgaggaggcc tgttggcttt attttattaa
541 tgccaccatc tagaatacag attcttgga
<210>9
<211>581
<212>DNA
<213>Homo sapiens
<400>9
1 ggtaaagact tttgtatagt tttcctgatg ccctaatttg ttccatttaa tttctataaa
61 tattcaaagg acatggaata ggatctgtta aatcaacttt attaatccca ttttaaatat
121 ctttcatatg cttatttttc tgcttgatca gcaaataatg aactaatcac tttcaaactg
181 ctagtttcta tacattcaat tatctgagat ttctattggc ttttacattg tttgatatta
241 tacgttttca aataaatatt catataaatg tctataggtc ttatagttct gttgtaggct
301 acacatgaac agcaaccaaa aagaggaaaa atcttctttg tccccatgct ttttccttga
361 attctgcact tttcatatta acattagccc ttgctttgtg atttgccttt gctttatttt
421 accctgtctt aatcttaacc ttcccaaata tttccataca gggtgcacct ctcctagaca
481 acacacagcg gagagtgtgc ttcccatgta ttcaatcttc gtctcttgaa aggagaggtg
541 ccctcattac acttcactgt gacacaggat acccttggtt t
<210>10
<211>442
<212>DNA
<213>Homo sapiens
<400>10
1 ttgagtatga atagggttta ttaggtcttt tataaaaata ttcactaact tttctctagt
61 ggtctcatct tctattctgt aaatggctct tagaaggaaa tgttttccag gtacagatac
121 ctaaatgggt atctatctca caatggcctg gagttctgtt ccctcctcat tccttaatga
181 gtgcttgtcc tgctgtgccc ttgcattgtt taatttgttg ctccttttta cgaaactcag
241 aaattcttga tccataaagt agggcttttc tgacgatcca tcatttgttt ccagatcaac
301 agcaaaacac aggaaaagtg catccagcac agtttcaaac acagataaaa aactatgggc
361 tactaagtag gcaaaaaaag ctaccaataa cagagggact gcccgcacct ggaatgcccg
421 attgtagtta aaagccatga gt
<210>11
<211>559
<212>DNA
<213>Homo sapiens
<400>11
1 ttttcttaat tatttctttt tattttaata aagcaaaact acaggtaaat gttttgccag
61 atgacttttg tgtacttatg ttctaacata gcacatgttt ggcaccaaaa gatcttagaa
121 actactatga aaaaccataa gattttaagt agttttctga cagaaatgaa catttctgtt
181 gcatccctac ttgtcactgg ctttcttaaa cacagaaata ttcatttcca tagtctttat
241 cgctttttgg aggatctcta agattggtcc catagccttg acaatttgtt ccaacaaatc
301 tgctgctgac tttgtgggat ttttggaatc ctcagttttt agtacatcct gcagtttttt
361 caaggtgtct atcagtggtt ttggaagaac ctggaggact tctggttctc tcagatgtgg
421 tgacatctga ttgctctttg gtgtcttctg tatagaagtc acttaattga agattcatga
481 tggggaattt catcaagtgt gaaagagaag attccagact cccaaggatg ttactgctgt
541 ttagcacaga gatgatgac
<210>12
<211>432
<212>DNA
<213>Homo sapiens
<400>12
1 ttttatgtta agtcactttt gagatattta ttattagaaa ccatccaaca tgaaatatga
61 attattaaaa tgtttttctc catgtttcaa accagaaaca gtaattcaga atgcaactag
121 catcctaatt tttaaaatca aaataagatg accagattaa taaaacttag cattcacagt
181 attcaatcta gaaaaaatat aattaataga atgttaaagc caaaagaaca tttgaaagac
241 agaaagagag aaggggagga gagaaagaga gagggaaaag agaaagcaag aaagaggagg
301 aggaggagga ttgagagatg gagagtttga gattgagact tcttatgaaa tatattttaa
361 cggcaattac tcattaacaa ctgtgcattg agaatatttg aacatgttgt tnaaagctag
421 gggaaaaatg tc
<210>13
<211>501
<212>DNA
<213>Homo sapiens
<400>13
1 tttgaaacat gacacagcct tttattattt cagatcgtga gaccaggtca gaagggtcgt
61 tacgctcatc atgatactac tgctttgaat accacacaga ccagcgacat ttcccattca
121 tttccccaac cttgtgggaa aaattttcag gagtacagca tcaatgaaga acacagtgtc
181 atgaaacaca aatgctgtca cagatgacag tcacgttacc atgctgaatt gtccagagaa
241 gctaaccagt tactactcag ggctgatgta caatagatgc aacgccaaaa tgagatgaaa
301 gagaattcag aataaaattc cgtcccttgg agcatattcc attggctttc tctgctcctg
361 cttccgctgg tatctggcct tctggtagaa aatgatgatg gttacagtga ctatatttag
421 aagaatgacg agcagtatga gccagaacga gtatccgtaa ctgtgggtcg ttcctttact
481 ggtggttgcc gggtanagca t
<210>14
<211>607
<212>DNA
<213>Homo sapiens
<400>14
1 ttcagattta tttttatatt tattaagcag taagcaaaca gagttggggg agatgaccta
61 aaatggtttt cttttggaat aatatttttt aaaaaatcaa ataactgtta tcactttaag
121 ttgcatgagg ctgaagctgc acctggagag gaatttaatt ttcatgacat gcaaaactga
181 ttaggcagtg aactctttcc tcccgcttcc cctgaacaca tttataaact tcaacggggg
241 tgaattccat ctaatactct gaaaaccatt tctcatctca cagtttaccc aaatcatgtg
301 catgactgca agaggaaata aacaagaaat ctttaagcat agataagcca caatggatag
361 ttaatcttgt acagacaatc cagcattaag gctaatttga tcttttaaac attttatggg
421 aaacagctgt tgagttttct ctagaaaagc ccacaaggtt ccataacccc ataggcatac
481 agcctcgaca ggcagggctc catcaggctc ctcttgaact gggcactcct tcacggaagg
541 caggaatgca cgtgtcttca cttcctgctg ctctgcacgc acgtcacgat atctggcaga
601 aggtggt
<210>15
<211>502
<212>DNA
<213>Homo sapiens
<400>15
1 caattcttaa tcatttattt tcaacacgtg tactataaag aacctaagaa atcagacaat
61 tttaataacc cataaacatg ttgaatccat ttgcagattt aaattttgta aaaatagctg
121 tcactgcctc catatatcaa gtgtactatg tttataatca catttatgct accgatactc
181 ctcagaaaaa aacagattct gcttggttct agcttcagta tcatgaactc caataatgcc
241 ttgaggacct ccaaaggaaa aaaacagatt ctactaggtt ctagctgaaa tattatcaac
301 tccaaattga agctgaagta ttatcaactc caaataatgc ttcgaggacc tccaaaaaaa
361 agagattctg cttggttgta gctgaagtat tatcaactcc aaataatgct tggaggacag
421 caatgtagat gattttgtaa tcacctttca tcggagtgac cttatataaa aaataagtca
481 ataatttaga ggttctaagt ct
<210>16
<211>576
<212>DNA
<213>Homo sapiens
<400>16
1 tattcacccc tcccttgaag gtttaataga caacaggaat ctgggctctg aaaagtcaca
61 aacacctttc ccaagatgat gagcaactgc aacaactggc caaatgtgtt agcagcagaa
121 aagctgggca ttacctgtgt gagaggcgct cagcatgggc agtgaatggc cgtgagcagc
181 gcaccagcta catagcctcc acaccggaag ggtgctgctg ctctgcaggt ccgtttcagg
241 cgggatccag ccatccacag gaccaagggg ctggagtgtt gggaacagat gattctgtgt
301 tccacagata atggtacaaa gtgactgttc atagataagg tgtaagcaca gcatttgaag
361 acagctcctc cagatggtct gtctgttagt gaattcttaa gcacttagag ccttgaagat
421 tgagaaattc taaagaaatt ttttaaaagg aggagggtgg tagatgtcaa agacacaaaa
481 gctctttgta ggtgctgact ggctcacttt gtccccaggt tcatcttaga gctcaagcag
541 attcaagaca tgaggcagag atgctagact tgcgtc
<210>17
<211>450
<212>DNA
<213>Homo sapiens
<400>17
1 ggctagggcc agcctgctgc aaaccctaga gttcacaaca aaaccaccag ctctgcctac
61 agagccagtt ctttccttcc acacccacat gagctcacat accttttcca tgggatcctc
121 ttacagctgc tttcattcca gctaccagat ggggacttgt atgtggccga gcataaccgg
181 ctgtgaacaa gcagcactct gtctggggag cccagttcag catctgaacc cccaggctaa
241 agggagagct ctggagccaa cacagcactc agtggtcagg aagggggacg gtgcggcggc
301 ggcactcgct gcttctcacc tggcacgggc ctgcaatctg ggtcactgtc ctgagtgcgt
361 ggatatctca taaaccaaga gccatgcctg tgcctcgggg tgtggttgtg tacacgcggc
421 cacaagtgca cacggctaat ccagttttgt
<210>18
<211>562
<212>DNA
<213>Homo sapiens
<400>18
1 agagatttac aaagattttt atattaattt aataaaacaa attcttaaat agaacaaaat
61 aaacacctaa tgagccactt atatatagaa tgcttgtgcc cgttggctct cgttcttacc
121 ttgggccctc ttacctgcca aagcctacaa ggcccttaat tctaaagcca cccacccttc
181 ccacaaccat aaaaacgtac agtccagtga ccttggaatg caggatctgc cagaggcctc
241 cactacgtgg gcattaacac cctggctggg gtggggccct gtactgtagc cttggccttt
301 cattcagaca gaaaggctct accttctttc ctccccaaga agagacactc cctcatgact
361 gtcactcact ggcacaattc ctgcctctca gcaggcatca gctgacaact cccggccacc
421 cctgtggccc tcttgtggcc ctctctagaa gaacatgaag tcccagctct gtggcaacca
481 gagccatcct ttcttccacc tcccgctcag agagctctgc gtgaatgggc agcccggctg
541 gctgtgaggc gccagcacac tg
<210>19
<211>492
<212>DNA
<213>Homo sapiens
<400>19
1 ttttatatta agcaataaac tattcggttt attttaacat ttgagaattt cttttgtata
61 taaatgacat taaaagattc tcagaagaag aaaacctaag ctgaatggat taaaggctgt
121 ctgctgaggt gctctccccg ttggcttcag aaatggattt tggttaggta taataagttg
181 tggagtcctg cagaggttct ttacacattt ctcttctttt gagcagagag agcaagattc
241 tcctcttacg taaggaggca tatttgcaaa atttcctgca ggtccgtagt tgcatacaaa
301 tattgcagtt gaagctcccc caaggttagg acacattgca actgcacaac cgacataaaa
361 tgaattggcc caaactaact gtgtataatg gccacagact ctggagcatg atagactatc
421 aaaatcataa aattgggttt cattatacca agccgtaatg gcatgtcttg gtgtgaatga
481 ctttattcca cc
<210>20
<211>528
<212>DNA
<213>Homo sapiens
<400>20
1 tttttttttt ttaaaatata aaggaatttt atttatgaat gtatagatgt acagcaaata
61 ggaaagataa tacattaaaa gaacatatac tataaccagg tagagtttta tctcaggaat
121 ttaaggatgt tttaatatta caaaaaccct tattataatc atattaggca atttaagtga
181 taaaaatttg attgtatcaa aagacaccaa ttccttttat caagctttta gcttccaaca
241 aacaagaata gaagatgtta tttctgttat cctaacaaag aacatttgtt taaaaccaac
301 aattaacttc atatgtaatg aaaaaatatc aaaaaaactt attacaattt tatgaaacac
361 aaaaacaaaa tagaaatacc tatgatttta tatttagaaa gagcaaacag gccatctaaa
421 actgttagaa caaagaaaat caccaaaaga tacatatttt aaaagttaat agctttctaa
481 taatagagat tcccatgctg acagcaacat agatataaaa cagccaag
<210>21
<211>443
<212>DNA
<213>Homo sapiens
<400>21
1 tttttaagta agcacagcaa taaagtttta atggaatagc tttggcccag gcagaggcag
61 ttcccagatg tctcaggacg cgtgtgaacc ccaagaagtt gggggcgtta tctgggccct
121 tgggatccat tcccctgggt ataaagtgtt ggtacgtggc tccaggcctg gcccactcag
181 cctcccccag gaaggcttct caagtggaga aggttcttgg cctcagaact cacggcgctg
241 ctgctcacgc tgacccccca ctagatgcag atcggtgtag aaaggcctgc cagggcaggg
301 atgagggccc caagctggaa gcagcccaga aatcctttta ccagaggaca actccctaat
361 ccgctgggca ggggcggggt gtcacacgca ggattccgcg acgactgtca ctgcctcctg
421 ggcgcccctc tgtgcgggag cgg
<210>22
<211>474
<212>DNA
<213>Homo sapiens
<400>22
1 tttgttattc agaatatttt attttaaact acaaattagc acagctaatt tgaatattta
61 aatttccgta agcactgtaa attgaataca ttttttctta atgatatagt ttttttccta
121 aaaatcctag gcatattcag acttaattca aatgggttgt ctaaaaccag acaatacaga
181 tgtggagcca tttgtggtag atggacgtgt atatcttgca gaagtctcca atggccttaa
241 aaagcattat tattggacat caacttatgg agaatcttat gaccactcat ctaatgcagg
301 ttttgctctt gttccagtag gtcaacagcc atgaaaaagt agctgtaaaa taattttcat
361 acacttgtct tattgtttca cagagattaa tattctatag cctattttct tttataaatt
421 aaaacaagtt acttttttca aatgtgtaaa agataatgac tgtattaaac tttg
<210>23
<211>266
<212>DNA
<213>Homo sapiens
<400>23
1 tttttttttt tttttttttt tataaaccac cacagagctt acaaaataaa caaaagaaaa
61 attgaaatta taagttcaaa gagtaggttt taatttaata agctattggg tatttagggg
121 aaaaccaatt aaacttggaa ttgcattaca aatttgaaat tgtaatgaag caagtagctt
181 ttatgaaatt ggaacataaa tataatatca acaaaaacat aagaaattcc tattccaatt
241 aagtctcaaa atatttgttt tacagg
<210>24
<211>545
<212>DNA
<213>Homo sapiens
<400>24
1 ttttttttaa gtattgctca cttttactgt tctctcttag ggaagggcat tctcaaaacg
61 tttccgcaca agcagaccat cccttttatt ttccccgtct gtctcctttc cttctgcttt
121 caaaatgtct caagagtatt tacaagagtt gagcaacaca ggcatcttta tctggggtct
181 ttatccacag agcagaggac aggaagtcat cactacagag acgaagcgat gtatggtttg
241 acccagtgga ggactttgtt aaggtggagg tgtgagtgtg gagtgtaaac gtgggacatc
301 cagggcagtg gagggtaacc actggagagg aagtctgggg accagtttgg gagcagccaa
361 atataaaata agcatttctg ttctaaatcc aaatgaacat tctacgctgc tgtcatctcc
421 agtatacctc agagatccta aagtttcctg aagttgtttg gaagtcacgg ccgatgtaaa
481 gtgaaagcgc acacatatct gtaagctctg agctcaggat ttcacgtgag gtcctttgtt
541 cggga
<210>25
<211>724
<212>DNA
<213>Homo sapiens
<400>25
1 aaaccttaac ccagagttat ttttattttc cagaacgtgt taggaactag tacttaaata
61 atctcaagtc cctgaggggc cagagatccc accatgcaaa atagcaaaca gacccaagac
121 ttggggagag gcggtgagtg catcagaaat ggatgggtac atctgattcc caccacgcgg
181 ggctcagctt agttagcagg agaccttcag actgagaaaa aatgcaagtc tttttttggc
241 ctctaatatc tgggaaggat ggagggagct caggagacac agaaaagatg gcgtatgaat
301 cctgtccggc ctgaacgagg ctggagttgt gcctctggat agcttcaagc actgatcaga
361 ttgtcagccc ccgctgcttg aacagatgct ttagagcctc ttccagttgc cggtttgttc
421 cctgaagccc cttcaccacc tgcgctgccc actcgaagta ttcctggact cgatgttctg
481 accatccctc tggggtgcag cgattcaggt ccctcagatt gtacagcttg tctgccagct
541 tcaccagttt ggccccgggg ctactgtggn gcgcttggct cacctgcagc ctctntctct
601 ccagcttggg cagagtcttg tcatctggta cctnctncac caggcgccgc acttgtgccc
661 caaagtgtag cttcaccctc atccaggtgg tgtctgtgtc ctccaccgtg tcatggagca
721 gggc
<210>26
<211>544
<212>DNA
<213>Homo sapiens
<400>26
1 aaagctgact ttatttttat ttgaattggc caagtaaaat gttccataca aggcaaacag
61 ttcaacatga aatatttaaa ttaaaaataa attacttcca tcctatataa atctctagct
121 gccacataca aatgaaagat accagttata aatgaaataa gttaaaataa atggttgtaa
181 ggagctaggt gtggtggcat gtgcctgtca tcccagcttt caggagactg aggtgggagg
241 atggatctct tgaacccagg agtttgagac cagtctgggc aacacagcaa aatcctgtct
301 taaaaacaaa cgtaattgta ggatcctctg ttacgaccag cataggttac tggtttgctc
361 cctaactttg ttctggactc caacatctct attgaatgag acttttgaac agtcctctgg
421 gatagcccct tcttaaaaga gcacttgatg cccaggtctc caaatcactt tcagatatga
481 ggatctggtg ttcagagtct aaaacaatgg ttgaagagca gagatagcaa ggtggaatcc
541 caga
<210>27
<211>639
<212>DNA
<213>Homo sapiens
<400>27
1 tttttgcctg tgttatcgat ttattgcagc tccaatatga gtccactcct actcaaaccc
61 tgattctcag gggcctgggg aaggccaccc cactaggggc cctgtcccca ccagagcctg
121 gacatgggac tctctcccaa gcaggggtgt tgtccttcac aggggcttcc acgtctctcc
181 cgggcctgtc cgcactctgg gcagggctgg cacctggcta ttccctcaat ctgggccctg
241 gggccatggc aatgtggaat ggtccaggtg ttcatgtcag tggggcttgg ggacatggcc
301 atccacgtag aagttcctgg tgatcttggg cagggtgaat tccgctcctt ccagctccgg
361 tgtcagcaca atctggcagc ccagccgcga gttctcctgg aggagggggg ccatgtctag
421 catgtcgtct tccctctcct cgggaggagg caggagatcc aggtggtctt cactcacata
481 cacatggcag gtggagcagg ccagggaggc ttcacaggcc ccttccaggt ccaccccgtg
541 gcgctgggcc aggtgaagaa cattgtcccc gactctgcca ctcacttgga tccgctggcc
601 tgagcggtct acgaacacca cgttcaccac gtncccggg
<210>28
<211>489
<212>DNA
<213>Homo sapiens
<400>28
1 tccctgtcaa tgtgttctcc gtcactcctt acacacccag caccgctgac atccaggtgt
61 ccgatgatga caaggcgggg gccaccttgc tcttctcagg catctttctg ggactggtgg
121 ggatcacatt cactgtcatg ggctggatca aataccaagg tgtctcccag tttgaatgga
181 cccagctcct tgggcccgtc ctgctgtcag ttggggtgac attcatcctg attgctgtgt
241 gcaagttcaa aatgctctcc tgccagttgt gcaaagaaag tgaggaaagg gtcccggact
301 cggaacagac accaggagga ccatcatttg ttttcactgg catcaaccaa cccatcacct
361 tccatggggc cactgtggtg cagtacatcc ctcctcctta tggttctcca gagcctatgg
421 ggataaatac cagctacctg cagtctgtgg tgagcccctg cggcctcata acctctggag
481 ggcagcagc
<210>29
<211>537
<212>DNA
<213>Homo sapiens
<400>29
1 ttttttgtgg tggtcactgc tcagtgtaat gtgcagaatg atttgttttt tgtttttttt
61 tttttggtcc ttcattgcat cctgccatac ccatgagcaa acagtttggc attaattata
121 tatcactgcc accctctgaa ctttgaaaac tgccatcttc agacttggta taatggaaga
181 ggctttctct ctccaataaa ccttttgctt cagggtatac tcttcggttt ttttccagat
241 gtattatgta tgaactttgt actatgtata gccagagttt tatttatttt ttaaaaaaga
301 aactttttct tgataaagga ataatggtgg tctagctagt tcttgtaaaa gtgatgcctc
361 ttgaaaaaaa acagtcctat tcactagctt ttagtaaaag aatcagatct tttctttctt
421 gttaccttgg agtcttaaaa actgattgct aaggtgaaac aattcaatgc ataagtatgg
481 agctaagtgc cttttggagg atttcttgga agagcatcta tggagatact taaggag
<210>30
<211>469
<212>DNA
<213>Homo sapiens
<400>30
1 gctttcggtg aattaaaatg tatttggtgc cagtggtgct gaacatagaa taaaaaacag
61 aaaaagggcc cagacaggga catccaggct ggaggttgga gtggagcaca gtcagatgta
121 ttcacttttc tagcatgggt ttcaaagtgc gtaaggggag aaaacgcatc atggattgtg
181 ctgtgcatcc tggacaccgt gcgaggtgct catagctgtg atcttgtctc ccacaactct
241 cttgggtgac agacgtccac tgtccacatt ttatagacaa ggagaaaggg aagtcaaatg
301 tctcgtccaa gtctacacag ctaaaaaggg gcagaactag ggtgacgctc aggcctcatt
361 tagagatcgg gggttggcga gaagtggggt gggcttctgg aggggctggg agagccccac
421 aaggctgcag agggtggtga gcccggagtg ggcctggcct ggtgtgggc
<210>31
<211>496
<212>DNA
<213>Homo sapiens
<400>31
1 tttaaggggc gagagatttt aattaacaca aatggctgtg cctagtcttt aaatctgtcc
61 aaagcaaatg gagtgaaagc ctgctaattc ttcagtgctt catctggcaa tgacctcaga
121 aaaaagagtc tccctcctgt attatcaagc tgacttcctt tagttccttg ttgttctgtg
181 tagatctttg ttcccagaat tctcacatgg tgttcatttc tgccagtagt cactctgtcc
241 atagttgtaa tgcccatagt acatccaacg ttcaggtttt tctcagaaga gctcaaggaa
301 atgcttggga cccaggaaga tttaaaaatg cttgcattgg ctcaaaattc tgctgcaaat
361 acagtgataa tttcaggtca ttggccttct ggtagttctt caaggcttca attctcagct
421 caatcacttt gccatgaaaa tcattctgaa ggatgttatt ttgttcctga tacttgaccc
481 attccatttt cctctg
<210>32
<211>577
<212>DNA
<213>Homo sapiens
<400>32
1 aattttattc catttttaat attttggtct agcaacttgt gatacataga tgacaatttt
61 gtgagttttt caaatgtgtg tacagatttt tgtaaatatg actcttttgt aattaactca
121 tgtacagcct catcctgtat agtttaatga tgaatgtgca ggggacctgt ctcaggctcc
181 tatatggttc ctgggcctta tagccaggtt tgtgtggcgc tcccgacttt tgtgactgac
241 tggtgtcttc ccatttggac tgtggcctgg ccagagcccc ttgcatatcc ccactgtcag
301 gggcagccag gactgttccc atcctcctgg aatgggggaa ccttccttat cccctgccca
361 catcccctct ccaataaagc acctgtgccc tcagcaatgg cctgccatgt gctgntgctg
421 ggatgtttgt attaaggtaa gtgtgggtat atggttttga gaccgggggg tgttgaacat
481 tttggggaat ttattatggg gcatcttaag ggaagacatt ccttgcttct ctgaaggata
541 cagcctccag ggggagactg ccattgtggg taagtta
<210>33
<211>528
<212>DNA
<213>Homo sapiens
<400>33
1 aattgagaca gggtctcact atgttgctca ggttggtctg agtaatgata ttatcttgca
61 tttatgtggt gctttacttt ttgttacaca ttcacagtaa ttaacctcat ttgattttca
121 acatctctac aacagaggtt tggcaaatat tttttgagtg gctgctaagt ggcaatcatt
181 ccacaaggta tttttacatt tgttacttca cttaatcctt tcaacaatcc tgagaggtaa
241 gcatttgctt tacttaacag aggaggagac ggagactcaa ggaacttaaa tcttaaaaaa
301 aaaaaaaacc caaaacaccc aaaaacaatt atttatgttt tacagataag agactataaa
361 accaattaac aggtactttc accacatcag cttgtaagat gaaatggttt atcatcctaa
421 tgttagtgaa tgacagaggt gtgcagtctt acaaatgaca cactttgtaa gtcactgagc
481 aatgtttttc tgccataagg gattttgagt ccgagaaatc aggtcctc
<210>34
<211>577
<212>DNA
<213>Homo sapiens
<400>34
1 tttatgatat catagtcttt tgactttatt ttctgagatg gaaaagtata ggcataggtg
61 tttttaatag tcttcttgat gatatccttt agaataatct atcaaatggc ttctttcatg
121 tttcctgatt atcagcattc atcagtgtta ctgtcagcct tgattaagtg gttgaaaatt
181 tcagagaaga ataagcaact tctgtgaacc tttccccaat ccctgagaat cataatcatt
241 acagaaatat tttatccttt catcaaatat ctctggaaag tagccgtgtt cgttcattgt
301 taatagggca aggtgcagtg tcatagaggg ttaatccatg taaattggct tccacccgta
361 aagaaatttt ctgaaaatca cgaatgtaag tcaggaaaaa accaaagaag gaaaatgaca
421 tagaccattc tgctgcagta gtgatcatgt gaagcacata acctttgtcc tcggggttcc
481 aatggagttt ctgttctaaa tcagtcccaa aattgccact gtgcaaaact gatgagcaag
541 tcagcatcca caccagataa ccaacaacag tctgatc
<210>35
<211>465
<212>DNA
<213>Homo sapiens
<400>35
1 tttattttta ttctttttta tttaaaagat tcccttttta atctgttcca aagtgttgga
61 agctgaacta tacaagttcc tgccacccat ccttccagta cagttttctg aggacatact
121 ttttaaatgg aaaaataaca ggaggaccct ctaactgaaa ccaggtaggc ccagagtgag
181 ctcctcaggc ccctgtggca gcctggccaa agctggcctt tatggagcca gcgcgtggag
241 aagtctgggg aaccggggcc cttccttctg gtgaggaaag ggctgagcaa actcatgttc
301 tctttagtga aatggtccaa attcagatcc aaaagcctcc attatggcat tccctggcac
361 tcttcttata ctttatacat tgaaggcagc tccctctttt atggccagta taagcaggca
421 aagaaacaaa ggaatataga tacatatatg tgtatatata tatat
<210>36
<211>698
<212>DNA
<213>Homo sapiens
<400>36
1 ttttgtcaat tgagcagatt taatttccct gagattatat tccataagtg atacaaatac
61 taccccttag accaggggtt ttcaaagttt gctgtgcaaa aaatcagcta ggtatcttat
121 taaaatggtc cccaacatgt ctgagctgga gcttcagtgt tcacaggtct caggtgatgc
181 tgatgctact ggtctctggg tcacacttta aagaggaaga cattagataa agtaaaaggg
241 agtcatgang aaaagggtgc acctaaaaaa catcacataa caaaatacta aagtccccga
301 gtgggagaat acaaacatgt ctctctactc tatatctaag aatcagcnnt ntggttntct
361 atattnncac tgtgtctgat tataaagact atnttaagnt tatggggctt ttttaacttc
421 aaanntnaaa gtgctcccga ttttttaaat aaaacacgac tatagggctt tttagaactg
481 gggctgtctt ggagagtgaa ggacactttt gggagatcaa ctcttttgaa atttatttca
541 ctgctaaccc tcgataatat tgcttttttg aggctaactc cagagaaatt aattggctct
601 aaggcaaggg catttattat attaataaaa gnnnnngggc tcctcgaagc acttacatta
661 cataaaaagt tcacacattg gaaactantc ccaaaagc
<210>37
<211>688
<212>DNA
<213>Homo sapiens
<400>37
1 tttcttggcc tgcagcttca tttgcgagag cgccgaggca ggacacagag cacagctgtg
61 ctggaagtgt ggggagaacc cggacagctc agtcctgcca gcagccgcaa agagccgagg
121 ctgccaggcc catttatgtc cctcatgtct ctagattttc tcgtcaccca gcctcaaaaa
181 tatatgtgtc tgcaaccctc agtctctctg ccgtttcttg attcctttcc aaacctcagc
241 cggggccctg gcctcagccc cccgtccctg cgtctgctcc tcttcacagc agctgctgct
301 ggctcctccg cgctcggcgc caggccctgg gtcctcagac gcatcactgt catcagtgtc
361 cgagggcagc cgggtgctgg ccacaggcct gttggggttt ccaaactctc tccctgaatc
421 cacatcgaag ggatcgatct cctcctcctg ggggctctcc ttggcattgg ccaagaactc
481 ctgctccgcc tgcagcacct cctccgggct gccgcaggcg cgtactttgt ccaggagctg
541 cggttcaggt ccaagaagcc cttgccccat ttaaacttcc gcagcaaaat gacagcaagg
601 tctggaaagc ctacgatgca gaaggtgcag caaacgcttt cacgcaggaa agtctgtagg
661 ggcggccata gttcacggng ttgcgggc
<210>38
<211>544
<212>DNA
<213>Homo sapiens
<400>38
1 ttttatgtta cactgtgcat ttatttacaa agaggttgga gaaacacaca gaatctggcc
61 cccctttgca ctggggagtc accatcgtca taataaatac agtaatttta aaaaagaaaa
121 aaaatactag attggaacag ctgagggtca tcaggcttcc cccattccct ctcacaggga
181 gtgggggtca tgagatagaa accatcttcc ttcccctctt ctacctccga atcctccata
241 attgtccagg gatcgaagtg aaagagtcct tctttccagg tgttaccaac ccctacttga
301 ccctcaaaac ccccaaatca gtgctccttc ccttcccagg gcactctgca gggaccacct
361 gagtcagaca cagagtctct gaccagggtg ccaaggggat atcttaaggg tccagggaca
421 tggagggggc actttgtgaa tgagaggggg ccatagctgg gcaaggaaag gaggaatgag
481 agggctcatc aggaatgaga gggagagcgg tggaggggaa caaacagact aggcttctaa
541 acta
<210>39
<211>542
<212>DNA
<213>Homo sapiens
<400>39
1 taaaaatcat ttttctttaa tacaaaatca cataaagaaa ggcatgttgg ctaaatcaaa
61 tattcactaa atatcagtga agtcaccact ggaatctcaa tagcacattt tcctgctttc
121 ttttctccct tctgctaacc attgaagacc agggtcatcc gtgggagcag atgagtagga
181 cacgcgtctg cacactggag gccctggggg ttgacatggg agcaggaagt ggaccccccc
241 accctgcaca tcccttctgt ttttcttgat ttcagtctca ctggcccagg ccaaatcttc
301 aagggtgtct agttctgcag ccagggagaa agtgatgcca agagaacctc gtctcctccc
361 tcctcagtct gctttgaagg ggaaataaat acacaggcct agtgtgtctg tgtggcacag
421 ggaggtggtt ttgccaggca tcttggaagg ttgtcttcta gaatcagagc catagcctta
481 cttgtggcct tggatctagg tctgtttccc cgatcgaaaa aagaacagct gttttatgat
541 tg
<210>40
<211>542
<212>DNA
<213>Homo sapiens
<400>40
1 ttttttttag agttgtaatt taaatatttt attaaaatac atattacaag aaagctaaga
61 tttacaatga acagagttat gaagcttctc aactgtcttt aaacgtttaa caacacaaag
121 ggactagctg tcctcaataa agtaacacag taacaaaaca tgtaacaaat tattttaagc
181 acagtttaaa acaccctata gctaaaacac tcatactatg taaatccaca taaactctga
241 aagaagaggt atttttccac caccactcca aggaacacgt aaattggcat agctatatgg
301 tagtctcata tatgaagata aacaaatagt aatgcattat ttagtacata attattacac
361 acaaaaggta aggcacagct caagcttatc taataaaaaa tatttaaaaa tgacaattca
421 taattgcaaa caaaacactg aaagaaaaaa ttcggaagaa tttaataaaa ttttgaatat
481 ttacaaattg caaatgtgag tacttgttat aaaactactt acacccatgt agaatgtgca
541 tt
<210>41
<211>624
<212>DNA
<213>Homo sapiens
<400>41
1 tttgacaccc aagaccatcc tttattgtag tattagttca tggtaactgc atgaaaaaac
61 atttcaggag gaatttacaa tttccagctt aaagaacttg cccaccaaca taaccaattt
121 atgaaagtca attcattaaa aggtatagaa cctcttgttg ggcatgatgg caagggacaa
181 agctacaact tggcctgtgc ctttggaagc tgaggcagga ggaccatctg agcccaggag
241 cctgagacca gcctgggcaa catagagaat ccgtctcaac aaaaaaaaaa ttttagccag
301 gtgtgctgtg agctgtagtc ccagctacaa ggtgggagga ttgcttaggc ctgggtgatt
361 gaggatgcaa tgagctgtga ttgtgccacc acactccagc ctgggcaata cagcaagact
421 gtctcaaaaa aaaaaaaaaa aacccaaaaa aactcaaaaa tgtaatgaat gatacccaat
481 gtgccttttc tagaaaaagt tgccaaatat atctcttgga tctgctgagc atgtcctctg
541 atacataagg caagcatgtt tctacaccca gtgttgatgc cagttagttt tcagaatcca
601 aactgatggc agctactggt cctt
<210>42
<211>500
<212>DNA
<213>Homo sapiens
<400>42
1 cgtggtttcg tctatttatt aaaaaatatt tgagaacaaa acctctgcct ctttgagtct
61 tgctctggca tccccagcat ctctgattct ccctggtgcc cccagctcag gaagaaggtg
121 gtagtgggga gagagggtca ggggggcttg gcagggatgc aggcaccatg acttttgtga
181 ccagttccta gagacgcatg ggtgtagcct caggaggaaa gcgagaggag ctttaccatg
241 ggaacgaagg aaagggacaa cattgggagg caaacgttgg gagactagtc cagaaacttg
301 cagttgagga tacaacaggg tcctagtgtt tcctccctgg gtcagcgtag aagtagagct
361 ttttcactgt cgaaggcggg attgaagtta gagattgccc tggcagaggt tggggagaga
421 gggactagga ggtggtacat gaatgtcttc tctcattctg ctaggtccct ctcagtggaa
481 gatagatagg ctggtgggtg
<210>43
<211>475
<212>DNA
<213>Homo sapiens
<400>43
1 gttaaaatat cttttaattt taccggcaaa atacatcaat gactaatata ttcccgtatg
61 gaatatattc ttattggaat atattcttat atagaatata tagactatgt atatatacat
121 atgtgtatat acctatatac atatatatat cttggagata taaaactaat tgggaataat
181 gtcatatata tagatagtaa gcaaacattt tttaaaacat tttaaagact ccaaactatt
241 catttctatc cacctataaa aaactagcaa ttaaacctgt caaatcacag ccatcttgct
301 ttacgcagat tcagaagcat gagatccttt tacctttgaa actctagttt caaagctgtt
361 ctaaagtgac ttggttttaa tttatatact tgcagggata agaagtagct gtagggccat
421 aaaaatgtaa agaatacagt atcgtgccca tacacaactg caaacactta ttttt
<210>44
<211>487
<212>DNA
<213>Homo sapiens
<400>44
1 ttttttttgt tctcaacttg tttaatatgg aaaaaggtca tcaaaacggt aggcaggttg
61 ctgtttttaa tacattcttg ggatgttggc cattcagaca gcattatttc aaatatagat
121 gagttatcca actttttttg actcaaagat agtttgctta gatttttttt ttttgagatg
181 gagtcttgct ctgtcaccag gctggagtgt agtggcgtga tctcagctca ccgcaacctc
241 cgcctcccag gttcaagcaa ttctcctacc tcagcctccc aagtagctgg gactacaggc
301 atgcaccacc acacccagct aatttttgta tttttagtag agacagggtt tcaccatgtt
361 ggccaggatg gtctcgatct cttgacctcg tgatcagccc gccttggcct cccaaagtgc
421 tgggattaca ggcgtgagcc actgcgcccg gactagattt taacaagacc taattccatg
481 ggattat
<210>45
<211>493
<212>DNA
<213>Homo sapiens
<400>45
1 aactgttaaa aatgttttta ttttttagta agcaaaattt tacgaaaagt cagattcacc
61 cgtggagcca gaaccttctt tctcacggga agactgtggt accagtgcgt gttggtcggg
121 tggttcatca ttagtaagct cccgtgggcc agcggcagcc tgaccaccgc caccctcctg
181 gaggggcttt tcccacggga atccttatgc cggaagacaa agtctctgca ggcaccgaag
241 gagacagagg caatggggct cccaggggcc agttctcttt catcatctcg gtgctccccg
301 atgtggtcac agccatcttt atacctgttg atgagcacaa agttgaaggt ctgtccagtc
361 accccagaga ccgtgatccc ggatgcgctc tagactgggg atccagggct ttggaaccag
421 cgtgaggctg anaatgtggt aggtcagccc agcgtcgcca tacgttgcct gcttcctggc
481 acactgtgcc act
<210>46
<211>361
<212>DNA
<213>Homo sapiens
<400>46
1 ttgattttga taggaaagct ttaattggtg actaagcttt gtaaaaagga tgtaaacagg
61 ggaaagaatg aaaagaataa gatttatcta cataatgaag tttgactttt tacagtaaat
121 aaaataccta tttattaata tttccaaata ttaattagat ttaataatac tatatatttg
181 ttacaatgcc ttcatcagaa aatttaataa ttaagaagat acttgaagtt cattcaaatg
241 gcacttgcag aaatgcaact taatttctag ttctatcata tctgtctcca aaatggacat
301 atatgacagc aaaaacaaaa ttctctataa atctctccat tagttacatt actatgtaac
361 t
<210>47
<211>595
<212>DNA
<213>Homo sapiens
<400>47
1 agtttttaga aaaaaagaaa aaagtttaat agcgatatag aaaattgagc acctataaaa
61 ctatatggtg ggctctgggt tacattgagc ttaagtagac caagtatcta tcccacctaa
121 attatcagca actccaggcc atgacccagt gtcccattct ccttcacggt ttgctggtgt
181 gtagcctcct ggatacaggc aatgtatata gatcgcagag aatgtccgtt ctggcctctt
241 ccttggaagg gtctaaaaac agaccttaag gagctaagtg acttccccaa agcccacagc
301 tccagtgcca ctgctgactt ttgggtgggg gtgggatcag ttaaagagga aagctttcag
361 tactgtcagc acatacacct gccaattaag gggctggata gagttcatct ctaggagcag
421 gacctccacc cccaccctcc accccagaag ccatgtcatg ctgtttcacc aggatcttgc
481 ctgaggttag atgggagaga acagctacaa gcttgggtgg agtcactcat aaacacaccc
541 tgaaagctgt ggagcangga gagtgcangc tntagagggc tctncatgat ccctt
<210>48
<211>503
<212>DNA
<213>Homo sapiens
<400>48
1 aataattgct tgatttattg tacagaagtg tccacgggct cacaattcta aggacatcat
61 catgacagca agtaggaaaa aaaattaaag taattctttc accaattacc agtttatctc
121 ttctccaatt cctttggata cgcctcctgc aagaagccga tttccagttg tatgtgataa
181 tgaaagggtt tttctttctt acgttaaata caagcgaagt gattaactgg aagatagcgt
241 ctgattgcga ggtaatcagt gattcagatg gtgtgggaat ggcacctggg gatgggggag
301 gcaggacgga gatggaggaa gctggtgcag cctagcctgc cttgtgccaa ggacacccaa
361 gggcagaggg actgagctct gggggaggac agatttgaca taactggtcc agcctcacag
421 tttacaggtc ctggagggtg aggaaagtgg gagctggctg cggatgcagg acaagaaccc
481 agggcttccc ttcattttgc ctg
<210>49
<211>535
<212>DNA
<213>Homo sapiens
<400>49
1 ttttatttat ttaatttttg gagacagggt cttgttctgt cacccagact ggagtgcact
61 ggtatgatca tagctcactg taacctcaga cttctgaggt caagtgatcg tcctgcctca
121 gccttctgag tagctaggac tccaggtgtg catcaccatt cccagctaat tttatttatt
181 tatttatttg tttgtttgtt tgtttgtttt tgtagagaca gggtctcact atattgctca
241 agctggtctt gaactcctgg gctcaaacaa tcctcccacc ttggcctcct aaagtcctgg
301 gatcacaagc atgagccacc atgcccaacc ttttctagtt tttaaatttt catacatatc
361 tattagatgt ttatagtgta aggttgaact ccattctttg cttctctgtt gctggtaaat
421 ttttgggtat atttttacga attttgcaca ttcttttaca tattggtaaa ggaacagtct
481 gtgatctgga tttattcaga tccttattca gaattaccaa ttgttttatt aatca
<210>50
<211>397
<212>DNA
<213>Homo sapiens
<400>50
1 tttttttttt tttttgttca ctagtttttc ctttattttc ttgggtatac ttaaatagct
61 actttaaagt tctattatta atttctatta agaaatgctg ggtctttttt tttttttttc
121 cttgattatg ggtcaaattt tcctgcctct ttgtatggct agtaattttt taattgaatg
181 gtaggcattg ggaataatac cttgtaaggc atctggctta tgttatcttc ctttaaatgg
241 tattgtttta tttcttgtta aagaggatta tttctgtttg aacttagtca aatgtggtcc
301 ataggctggc tatttttgta aatgaagctt tattggatat agccatgccc atttgtttaa
361 tattaatata ttatctggct tcttttgtgc tataata
<210>51
<211>535
<212>DNA
<213>Homo sapiens
<400>51
1 aggttttttt ttttttaata tttttaatgt ttaatagtta aaatttttta acaatttaac
61 tttaaaaagg tcacacattt tctgatccag caatgcccca atcagattgt ttcattttat
121 tattattatc aacactgtcc cctttttggc acctgtaaaa tagttccttt cgggagtttg
181 gagccaggcc aggcaccgtc ggtgcatggg atgagatggg caggtttgga gctcctctgt
241 ctagtgagga tcacggtctg cagagaaggg ttggcctccc cgtctcctat caaggcttaa
301 agcaaggaga accatcccaa atttggttcc ttttccccta agtatcctta gaggcaatcc
361 accctgtgac taggtgacta ggtgaaggac tgaggtccag aaaggagcta tcttaaacct
421 ggaatcccat ttcctagtct gcagccttaa gcagttaccc tctcagacaa ctagccctct
481 ccttcctccg catgaaaacc catggcttac agggatggtt gttgctttcc ctaaa
<210>52
<211>545
<212>DNA
<213>Homo sapiens
<400>52
1 tttttttttt ttaattttga aaagactgtt gatgtcactg tggtttatta ggtaaataca
61 aagtataggc tcttgcattt tttaaaaagc aaaaccaaag agattagaaa ccaagtacac
121 atatcctcta gaagagaaac ataaatcagt tttaacaatt aggcacttaa aaatgtaaat
181 gtaagacaac attatagaag tataaactat agttacactc ctaaattcct cctgaaatgt
241 ttacaaacac aaaatcacaa gcatggaaaa caaatttcct ctttatcaaa aaaggaacct
301 gaatttgaat ccaatgtgat aaaccaatga ttaaggtact ggtgggtagg aaaaaagagc
361 ttctgaaatt tacatatttg attaaaatgt aagcatttca taaaactatc acaatagcat
421 acagtagata tcataatgaa aaatatatgt caggaaaata atgaatctag acttaaaatt
481 ttactttaca acaaggcact taacacattg aaacagtaca gtaaatttcc aaaagaatgc
541 aattg
<210>53
<211>516
<212>DNA
<213>Homo sapiens
<400>53
1 aaaacaaacg ttcttctttt aatacagcca ttgaaaagat gacacattaa gaaacatgta
61 aacactgcag ctgcttaatt acaagttgca ctgcttgatt tagtacctat gcactcccag
121 gtttggggac cttaagagag ggggacagga gcctcccctc actttcacag ttggatagag
181 aaggcaagaa tgtgggtaga gtaagaaaga gaaaacagaa gacctggctt gtgcacagcg
241 cctgagagaa tcaaagcaaa ttctgtcttc taagtcctcc cagaagaaag gtttaagatg
301 ttaggaaggt tggaaaatga acgtgtgttg tcagttggga ggcaaaggaa ttgacaaatg
361 cttctagtta gaatatcagc taggaaaagg agggatacag agcctgacct catgctctga
421 aaaggcaagg aacccagaac ttgcctccct tatccactta agccccaacc ttgatcatca
481 agggcagcgc atgggtgatc ctgttcccat gaggat
<210>54
<211>571
<212>DNA
<213>Homo sapiens
<400>54
1 gaatgatgct tttttttatg atcttaatta cattaaagga tttaaaaaat gccactgatc
61 tcacagttta caatatccaa atcttcaaac ctgctggaag aagtccacag cacagcctgg
121 aaattgcatc cgttgcattc tctcgtgcag ttaccttctg ccttgatatg tagtcagttc
181 ttcctgaagg atggaagctc tcttttgcag aaaattaacc tgtgatttta gggaggaaat
241 ggtgtcttca ggttcttgtc ttagggatgc tggcatcaat cctttcaatt ttgtttcata
301 ttcttgtcgt atgtaagtta tctgttcctg tgactccaat tctttgtgtt gtaatttttt
361 ctctgcacat cgcacctgat tagaacggtt ttctaattca tcttgtaaaa ccttgattgc
421 ttggtcatta tctctaatca gctgcttctt ctcatcttca aacttttgtc taacatcctg
481 gagccgcctt tctgcagcaa gctgctgctg gctgttctct tctttcagag aggaaatggt
541 tgtctgaagt tctgctatga tctgtgaaga t
<210>55
<211>1711
<212>DNA
<213>Homo sapiens
<400>55
1 tttttttttt taaatctaag ctattcccat ctcccccatt ctatgctggg gtgatatacc
61 acaagaagtt acaggaacaa ctgctaaaag aattaaacat cttgggcctt tacacagctg
121 ttgctatatc atggctttgg tgcatggtcg gtcacagatg ctgtcaagag gcttatgttt
181 agttatcctt ttgcttcccc aacccccaca ttaaaggtct ccttcacctt ctctgtcctt
241 tttgctacct cccttcttcc tgctccaagc tcccacaaac cagccttaat aaaagaggaa
301 ggatcaaggc aacactccac atcagtcata tttcagggca gcttgatgtt tgtttgctaa
361 tagatggttg gtattatcta accaataggg tgactccaag ttttaaaaaa cagcaagact
421 aattcagaaa taatattatt tcttaatttt tttaaaaata gagatggggt ctcactttgt
481 tgcctaggct ggtcttgaat gcctaggctc aagcaatcct cccaccttgt cctcccaaag
541 tgctaggatt acaggcgtga gccattgcac ccgggctctc agaaatctta aaaaggattt
601 agtttcattt aaaaataaca aacacagttc cccaaatctg aaatttagtt attgaaactg
661 gaccatgttg tccatggaaa acatatctta ctttatacca gattttaaaa ttaacactgg
721 tgtaagtgca gcctaaaatt cctctgagcc ccacttttac ataagaaaaa ttattgaata
781 tgataaaggt agcatttcca atcagtgaga aaagataggt tattcaattt gtgttgggac
841 tggtggatat atatctagga aaaaaaagta cagactctaa atattgaaag gtaaaactga
901 aaacataaaa atatttgaag aaatcactgg aaaattattc tacaaactgc atggggaatg
961 acagtctgtg ataatagtaa ccaagaacca tgaaagaata gattggtaac aattcagcta
1021 cataaaaatc cctaaatttc tctatggcag aaaccatgaa acagataaat ttaccaaact
1081 ggaaaaaatt ttcacaaatc atgtcacaaa gagctaattt tcttaaaata tataaaaaag
1141 atctttcaaa gtgtcataca caaaacactg cttttcgaaa aacataagct cctacaaagc
1201 agtaagaaaa tgatgaacaa atagaaaaat gggcaaaggt gatgatttaa cagttcacag
1261 agaaatacaa atggcttcta aaatatataa aaagatgccc aacttcgttc ataatatgaa
1321 aaatgtaaat taagactaca ctaagataca atttttcaca gatctgtttt ctaaaaataa
1381 aataagcttg agagagagcc tcttatctga attctgggac agcctgattt gcatgaggga
1441 aataggcatc ctcctgcact gctggtggga gggtaaaggt acagtctcag tggaggacag
1501 tttgctgtta cctctcagaa ttacaaatgc atgtgtttgt tttgatgtag caatttccca
1561 tctaggaatt tattcttgaa agacagtcat acaagatttt cacaccagca ttatttgtaa
1621 tagcaaaaag atgggaaatt acctaaatgc tcatatatag gggactgcta aattgtggaa
1681 ttccatgcaa ttctaaaaaa aaaaaaaaaa a
<210>56
<211>1720
<212>DNA
<213>Homo sapiens
<400>56
1 aatacttttg atcacttcca tttgcctgca aagccagaaa cttctctcaa gaagattata
61 gctgagtatg taaaacaaaa tatatgtaca actgtaatac caacaagcac agtggtaagt
121 tataacaaga tatacgaagt aatagaaatt aagaagtgag agtatcttca ggcgaaggca
181 actgggaagc tggagctcaa agtttaaggc tgtgttaaaa cacaacctaa agttcccagt
241 agaagcttgc tatagacttt tggtggctct gagaattccc ctggtcacct cagtgtgagg
301 ggtgggtgat tcttaacctc tggtgggttt tgttgcagtt tagctgctgt ggagggattt
361 cctacaagga ctggtctcag aacatgtatt tcaactgctc agaagacaac cccagtcgag
421 agcgctgctc tgtgccttac tcctgttgct tgcctactcc tgaccaggca gtgatcaaca
481 ctatgtgtgg ccaaggtatg caggcctttg actacttgga agctagcaaa gtcatctaca
541 ccaatggctg tattgacgag ttggtcaact ggatacacag caacctattc ttacttggtg
601 gtgtggctct aggcctggcc atcccccagc tggtaggaat tctgctgtcc cagatcctag
661 tgaatcagat caaagatcag atcaagctac agctctacaa ccagcagcac cgggctgacc
721 catggtactg agaatccatc ctgcacctcc tcaccatgga aactggcaag cctcataaac
781 gaacagcagt gggtgctgaa agcagcacca aatggagatt tggattccag ccccccagtg
841 acagcccagt gggaagaagc aaactccaga tgggcagaag gcagggtgca caggtggctc
901 cagtctcagg aggatgcgcc tcctctcccc catcccagcc ctcagcattg tgccagagtg
961 atacccttaa gtgtttgggt ttatgttttc agttttgttt gggaaacagc agttgcacag
1021 agagttgggg gtactgctgc tgccttttca ccgaggcact gccaccacca gctctagcag
1081 gggtgctcct gagcttggcg gacatactta gatcctaacg tgccagtgag acctggctgt
1141 ggagagtagc actggcagcc ctgcctggac tccacttggc atgataccag ctccagaagg
1201 gaagggagtg gagcaggcag tgaggagaga gcctgggggt cggctgggga cagccgtatg
1261 tgctaggtag gagtggaggg agatatgttt accaaatgcc tgtcctgcca tcctcccagg
1321 tagtcagagt gagctacatc ctgccccacc ttcatttcca tggaaacacg gcagctagga
1381 cacggggtac aacagcagcc aaattcttcc ccacctccct tacttcgaaa aaaagtttgg
1441 aaccctggtc cctatactct gcagtcagaa gtgggactga gccatacatg cccttgaatt
1501 cctccctgtc tggccctccc tctccagcaa gcagggtttt ctttaacttg gcagtgtgca
1561 gaggagaagt ggtaacaccc ccaccccatt cccctgcatc ggggctcagt attcctacag
1621 ggtaagaggt aggaatcttg ctgggacgag gggagccaga agtggcaata aaagcgtgtt
1681 gacctggaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
<210>57
<211>653
<212>DNA
<213>Homo sapiens
<400>57
1 tttttttttt ttttttgcat acagaattat tttatttaac ttaaaccatg tagtacttta
61 ctagaaaaaa gcagagtaag agaaactaac gttgccttag cttcagccat tcaaaataga
121 cagtttcttt tttccattat gtaaagaatc cagagtatat cgcaataaca ggaataaatt
181 cttacaacag aatatacaaa aacattttga aatttttttc atctactgat tttttatata
241 aacaggattt tttaggaata atttatacac agaaagtcat tttatgtaac aaattggcca
301 tgttattacc tttttttttc ttacttaaaa aaattttttt ttaacaagaa aactcagaaa
361 atgcattatt tgcggtgcat ccattccatc ccgccttctg gtttgatttt ttttatccca
421 gacaaaggga tacccagagg tagacaaact ctggcaaacc tctcacctca acctcactgg
481 cttaaaaagc agacaggtgt tttcaccggg cgtctcttcc accggtggat gtgtgtgtgc
541 aacgccaaac atccaaatga aaagttgaaa acaaaaccca aatagtttcc agatctttct
601 cctatgtagc gcaaaaaccc caggtgtttc ccatgataga gatattgtgg agt
<210>58
<211>1037
<212>DNA
<213>Homo sapiens
<400>58
1 ttatttchcc gabctccact ctggctccca ccccacaagc gtcagagcag gaaacaagct
61 tggstgagat gcctcaggcc tggtaacctg aggtgtagag cacccagaag gaagggtaaa
121 agcagggggc aaagcggtgg ccctcccttt ctgggggtca cttctgggct ggggccagct
181 gaaacctgtg tccaagtagc tttcagggct ggccacaccc taagccttgc aaaagggcct
241 cctgcaaggg ctggcccatg gggtccccac cttcccagcc agtgaggtta gcatggttag
301 gagtccacat gtgtgcaagt gcttgtgtgg aggctcatgt atgcatgtgt gtatatgcaa
361 agctgcacat gacaatgtgc atgccagtcc agagttagat gtacctatgc agttgccctc
421 aagcgaaggg tcatatttgg aaacaaggat ggctctaaac atgtaagcgt gcatgtgggc
481 atgtatgtat ctggggccta aggaggtggg gaagtgggtg ttggggtaag ggctggcctt
541 cagggcattt gcagaaggag gagtgggtgg gagggaaagg ctgggcagag caggggaagg
601 agtgaaagcc aggcaggaaa gtggaagaac aggagaagct catgtaatgg attaccctcc
661 acaggattat gttccttgat tcctgagagt tttttctctt gattttaccc cctcagtcta
721 tcactgcaag agaaagaggt agaaaagaca aacagaccac aaaagacaag aacccagaca
781 tatagacaga cgcacctgtt gcatgtgcat gagccagagc ctgggagaga agagagagcg
841 tgcaagagag agctcagagc aggcaggcag cccacccctg cagcagtgct gggctyactg
901 gagccctgca gragtcagca gccctgtatg cactcctctg gtttgtcagg taacaggggt
961 gcccgccccy tcatgatcag caccggkggt ggggagctgc ttaggtgctc aaryggtctg
1021 accatgggkc tggtctc
实施例1
人肝脏组织的mRNA的分离
组织分离(Tissue isolation)：肝脏来源于5个成年男性，在肝脏切除手术后， 将肝脏组织立即置于液氮中冷冻保存。
mRNA的分离(mRNA isolation)：取出肝脏组织，用研钵研碎，加入盛有裂解液 的50ml管，充分振荡后，再移入玻璃匀浆器内，匀浆后移至50ml新管，抽提总RNA (TRIzol Reagents，Gibco，NY，USA)。用甲醛变性胶电泳鉴定总RNA质量。用带Oligo d(T)的纤维素柱分离总RNA中的mRNA，定量。
实施例2
cDNA文库的构建(Constuction of cDNA library)
以mRNA为模板，合成双链cDNA。补平末端后，加含EcoRI切点的接头。磷酸化 EcoRI末端后，用XhoI限制性内切酶消化1.5小时，再进行片断分离。过柱筛选长 度＞500bp的片段，用酚-氯仿抽提，乙醇沉淀，无菌水溶解，连接至Uni-ZAP XR载体 (Strategene，CA9203，USA)，以ZAP-cDNA Gigapack III Gold Cloning Kit (Strategene，CA9203，USA)进行包装，宿主菌使用XL 1 Blue MRF’ (Strategene，CA9203，USA)细菌。涂板并测定滴度。
实施例3
测序及数据库建立(Seqencing and Database Constructing)
挑选文库中有外源片段插入的克隆，扩增后抽提质粒(Qiagen Germany)，用T3 和T7作为3’和5’端的通用引物，采用终止物荧光标记 (Big-Dye，Perkin-Elmer，USA)的方法，在ABI 377测序仪(Perkin-Elmer，USA)上 进行EST大规模测序。测序结果用FACTURA软件去除载体序列，传输到SUN Ultra 450
Server上进行下一步的处理。所有的序列信息再用GCG软件包(Wisconsin group，USA) 中的BLAST和FASTA软件搜索已有的数据库(Genebank+EMBL)，将无同源性或同源性 低于95％的序列视为新基因建立数据库。
实施例4
基因的全长克隆(Cloning of Full-length cDNA)
在得到的新基因片段序列信息基础上，进行cDNA全长克隆，分两阶段进行：
(1)“电子克隆”(Electronic Cloning)
以新基因片段序列作为探针搜寻dbEST数据库，将重叠序列＞50bp，同源性在98％ 以上的表达序列标签(Expressed Sequence Tag，简称“EST”)序列认为同一序列 (Consensus Sequence)，取出并用AUTOASSEMBLER软件进行连接，部分EST可以延 伸探针序列。再用STRIDER软件分析被延伸的序列是否具有完整的开放阅读框架(Open Reading Frame，ORF)，用BLAST搜寻Genbank或SwissProt以确定该序列的核苷酸 和氨基酸水平上是否与其他物种有同源性，以帮助判别所得到的基因全长完整性如 何。通过电子克隆的方法，通常可获取人肝脏相关基因的全长序列。
(2)cDNA末端快速扩增(Rapid Amplification of cDNA Ends，RACE)
如果通过“电子克隆”方法仍未得到完整的cDNA全长，则在已有序列5’或3’ 端设计引物，在人类肝脏Marathon-Ready cDNA文库(Clontech Lab，Inc，USA)中 进行长距离PCR反应。然后对PCR产物克隆、测序。用AUTOASSEMBLER及STRIDER软 件分析被延长的序列有无完整的ORF，如无，重复上述过程直至获得全长。
(3)RT-PCR
对于5’和3’端的已知的序列，如果中间有一段间隙(gap)无法从已有的公共 数据库或自身数据库获得，可考虑采用RT-PCR的方法。在序列5’端设计引物，3’ 端引物采用Oligo-dT，在肝脏总RNA库中进行扩增。然后对产物进行克隆、测序。最 后拼接便获得全长。
通过组合使用上述3种方法，可获得人肝脏相关蛋白的全长编码序列。
序列表
<110>上海人类基因组研究中心
<120>人类肝脏中表达的表达序列标签I组
<130>NP-10041
<160>58
<210>1
<211>563
<212>DNA
<213>Homo sapiens
<400>1
1 taacaagggg gcagtcattt aatgcagaaa tccagttaac ataaagagac agaggttgaa
61 caacaggtct tcaaacaata ctgcatagtg tcacgagtta gctcttaagc acgtttgatc
121 tgtttatctt atgatttcga ttccagtaca aagacagaga agagacttaa aaaaaaaaaa
181 acaataaggc aacagaagaa gaatcttcct gtgacaagga acgtccacaa ataatgcaca
241 aatatttggt gctgacacaa taagacacca tcaggacaag ttctgaagat gctgcattaa
301 aatttaacaa gcatgataca atgacaagaa aattatactc gctttgttac gaatcctttt
361 gcaagtagaa atgactctcg ggtaattgtt acatacaaac tttctgaaat aaatggaaat
421 catacaaatt tttccattgc agtttctctt tctctacacc tagaaatgtc catggcactg
481 ctccctattc tcacagtcac gcataatagc cttaaagcct tgaatccaca gtggcttgtc
541 cttagaaggt ggaggttgct gat
<210>2
<211>659
<212>DNA
<213>Homo sapiens
<400>2
1 acattttaga gttgtttact tttattaata aaaagttaga tcacttatat atatatacat
61 tgaaaaaaac tattattgtc cctttcctgg tgaaaaggag tatacacaac agacctttgt
121 gatattctgc aacaatgacc catattgctg tggaattctc actttttagt agaaccttta
181 aaaactcaag tgagctgtac aacgccccga ttgctttaac tccagtgaac cacggaggta
241 taaagacgct agagttcttt gtaattcttc agtgccaaaa ataataaagt tggaaacttg
301 gattcctgtt tgactctact gtattaagtg atcagaataa aattactgta aggctaatct
361 tcaaccactt catggttttc attcttgctt tctatagtga acatctggtt gtttccactt
421 ggctctaaac ccctttcctt ttgggattca gcccactact catccatgtg attctgacag
481 gaggttagca atgacagtgc agatagatag cccaggcctg gccaaagatc acaggcccca
541 tcccctcttc cacagggact gggtccatgc aagggcaggt gattctgggg aagaccagag
601 tccttttata ganttgattg tggacctgaa aaggaagtnt cccctccctt tgancatgg
<210>3
<211>604
<212>DNA
<213>Homo sapiens
<400>3
1 tnataaacat atngaaaact ttantagaaa tatanagaaa aanaaataac ttgcctgnga
61 ggtttcctgt cccttcagga tggatganca acagatgggg cacctaggtc cagtggggct
121 gctcccgatc tactgtttct tcctccagga gcaaggcatc tagctccttc cagccgctnc
181 tgagcagggg gcccacatca gggctggggg ccacattggg aggaacagtc ctgccccctg
241 cagcccggac cccacggacg gtcttcgtga tcgaggaagg ctgctgtccc gaaattccac
301 agcccgccgg agcttccttg agctggtgaa aatcagagtc ccattgcgct cccggggttc
361 ctcaaagatg gtctcaaagg tcctcctggt tgtggggtga ttggtaattc ttggttggtg
421 taaatttctt ccaagctgaa ctccttcttg gttcaacctg attgggtcga ggcagtccca
481 ttggtgtaan gtttaagctg aggacgggct ggtgttctgc ggnattctga atcgngaacc
541 tttcccatgg tcttggtctc aaggttngaa agcacctggg tcncttgaag gctcttggct
601 cctt
<210>4
<211>629
<212>DNA
<213>Homo sapiens
<400>4
1 aacaaattgt attattacac attcctagtt gctgcttgta atagaacaga tttcaatctc
61 agaaatgttt atctgagaga catagatcag gtttacaagg acaagaggtc aaagtcatgc
121 cacagacgat ccacaccacc tatgtatgca ctctctctct tgcacacaca cacgcacacg
181 cgcacacaca cgctgagtct catgtgctta cctcgtctga ctgccgctgg tgttatatgt
241 agcttccatg cctggaagag gcacatatgg taacatggtg tggctaaagt aaagcaaaag
301 tacaaaagca ataggtaagg gcagtgggat aacaggaaag gttttgatgt tattgtgggt
361 attagcacat gatagcccca agaagacaag aaatgtcagt tactcagaaa gaggaaagct
421 ttccaaccag gagagttata tttatgtgcc ctcactggaa tggaggcaga ctgacaggaa
481 gattattttc caacttgaat ggaaagaagg cagagacaga aagaaagaac agtggctggg
541 caagtggctg atgccnataa tcccagcact tgggaggctg aagttggcaa tcgcttcagc
601 ctggagttca gacccagctt ggcacatgg
<210>5
<211>716
<212>DNA
<213>Homo sapiens
<400>5
1 agatggagtc tcgctctgtt gcccaggctg gaatgcagtg gtgcgatctc ggctcactgc
61 aacctcctct tcctgggttc aggcaattct cctgcttcag cctcccaagt agctgggact
121 acaggcgcat nanccacgcc gggctaattt ttgtattttt agtagagact gggtttcacc
181 gtgttagcca ggatggtctc aatctcctga cctcgtgatc cgcccgcctc agcctcccaa
241 agtgctgggg ttacaggcgt gacacncgtg cccggctgag aacattttac atatatgcga
301 aatagctacc cagtcctgat tcgactagag cactgagtga cacacattaa atgttaagtt
361 tgaaaagact gtaaaacatt cacatatgac agctcttagt gaagtaagag cctctcatat
421 tncctaattg tttgaaacat tccaggagag ctaggttccc gtattctcct ctagaagtgt
481 gtatagggct ccctcccttg tttggngata ttnttgatat ttcctccgaa tgatgtttac
541 ttgactctgg ggcaagctga gcttttccac agatttagtt acttcttcac taactcactc
601 ntcagcaagg ggaaactccg atgaatnagt tcngtattgg naactggtag gttgttanca
661 attatttcaa gttccgatgt atccgaatgg gnaagtgagg nccgtattgg aattct
<210>6
<211>392
<212>DNA
<213>Homo sapiens
<400>6
1 tttgcaggtg actacgcatc atggtaagtt ttatacccta gtcaaaatga aaaatagcaa
61 aaaccgcact gtaaaaaaaa aaaaaaaatt ggtttccttt agtagatagt atttcaaccc
121 atcatattct tattataaat aaacagaaca atcttaagtt gacagatatc aaagagacct
181 tgatctgatt ttggtgccaa gtgaggtctt aattcctcat tcctgcctta agtgcttggt
241 gtcatacagt gggtggtaca aagctgtttt atgcctaata ttgctaaatg ggacccttct
301 aattgatttg aaagacatta taacatattg tccagacttt aagacttaaa gagtaggaaa
361 tactactttt agtggctaaa tttattcatt tt
<210>7
<211>488
<212>DNA
<213>Homo sapiens
<400>7
1 gatcccagca gtgtccagaa gaagaccaag gacagaacag agactaggtt tggtgagatg
61 ggacagattt tgggaaagat catgatgagc catcaaccgc agccccagga agagcggacg
121 ccccagcggc gcctcagggt accccctcca ggaggtggtg gatgatgaag tgttgggacc
181 atcaggtgag gggactggag aaagaagagg tggcatagga ttgactaaga tgaaggaagg
241 gggccaggcg tggtggctca cccctgtaac cccaacactt tgggaggctg aggcgggcag
301 atcacctgag gtcaggaatt caagaccagc ctggccaaca tggtgaaacc ccatctctac
361 taaaagtaca aaaattagcc aggcggtagt ggtgtgtgcc tataatccca gctacttggg
421 aggctaagac aggagaatca cttgagcctg ggaggaagag gttgcagtga gccgagatcg
481 tgctactg
<210>8
<211>569
<212>DNA
<213>Homo sapiens
<400>8
1 gggtgaaatg agttactaaa tgtagcattt atttataagg aatgcattgt gaatagtttc
61 tcagttttca ttatggaaag atgatgattt cagcccacat tcagtgtatg tttctaaata
121 acacaatcga caggactgtc tgttcagtac aatggaggac agctttttca gggcaaatgg
181 gatttcttga taatgctaaa tctgtcttgt cagctgaatt tcttgggctt tatgtggcag
241 tgtggtaaaa atatatgatc agatttcact gttaagaaaa ttctttcagc aatacatgta
301 gagtcaagtt tcttgcatgg ataactgaac atgtgggtta tgagatttta aaaaatgtct
361 cgtgacaaac tttacggaaa tgcaacaatc tggacatcta gttttgtctg agagtggcgt
421 ggatatgaag aactgtgctg ttggtgctga tgccacacta agttttggca gtcacactct
481 tggttcttca tatttgagga gatgggatgg tgaggaggcc tgttggcttt attttattaa
541 tgccaccatc tagaatacag attcttgga
<210>9
<211>581
<212>DNA
<213>Homo sapiens
<400>9
1 ggtaaagact tttgtatagt tttcctgatg ccctaatttg ttccatttaa tttctataaa
61 tattcaaagg acatggaata ggatctgtta aatcaacttt attaatccca ttttaaatat
121 ctttcatatg cttatttttc tgcttgatca gcaaataatg aactaatcac tttcaaactg
181 ctagtttcta tacattcaat tatctgagat ttctattggc ttttacattg tttgatatta
241 tacgttttca aataaatatt catataaatg tctataggtc ttatagttct gttgtaggct
301 acacatgaac agcaaccaaa aagaggaaaa atcttctttg tccccatgct ttttccttga
361 attctgcact tttcatatta acattagccc ttgctttgtg atttgccttt gctttatttt
421 accctgtctt aatcttaacc ttcccaaata tttccataca gggtgcacct ctcctagaca
481 acacacagcg gagagtgtgc ttcccatgta ttcaatcttc gtctcttgaa aggagaggtg
541 ccctcattac acttcactgt gacacaggat acccttggtt t
<210>10
<211>442
<212>DNA
<213>Homo sapiens
<400>10
1 ttgagtatga atagggttta ttaggtcttt tataaaaata ttcactaact tttctctagt
61 ggtctcatct tctattctgt aaatggctct tagaaggaaa tgttttccag gtacagatac
121 ctaaatgggt atctatctca caatggcctg gagttctgtt ccctcctcat tccttaatga
181 gtgcttgtcc tgctgtgccc ttgcattgtt taatttgttg ctccttttta cgaaactcag
241 aaattcttga tccataaagt agggcttttc tgacgatcca tcatttgttt ccagatcaac
301 agcaaaacac aggaaaagtg catccagcac agtttcaaac acagataaaa aactatgggc
361 tactaagtag gcaaaaaaag ctaccaataa cagagggact gcccgcacct ggaatgcccg
421 attgtagtta aaagccatga gt
<210>11
<211>559
<212>DNA
<213>Homo sapiens
<400>11
1 ttttcttaat tatttctttt tattttaata aagcaaaact acaggtaaat gttttgccag
61 atgacttttg tgtacttatg ttctaacata gcacatgttt ggcaccaaaa gatcttagaa
121 actactatga aaaaccataa gattttaagt agttttctga cagaaatgaa catttctgtt
181 gcatccctac ttgtcactgg ctttcttaaa cacagaaata ttcatttcca tagtctttat
241 cgctttttgg aggatctcta agattggtcc catagccttg acaatttgtt ccaacaaatc
301 tgctgctgac tttgtgggat ttttggaatc ctcagttttt agtacatcct gcagtttttt
361 caaggtgtct atcagtggtt ttggaagaac ctggaggact tctggttctc tcagatgtgg
421 tgacatctga ttgctctttg gtgtcttctg tatagaagtc acttaattga agattcatga
481 tggggaattt catcaagtgt gaaagagaag attccagact cccaaggatg ttactgctgt
541 ttagcacaga gatgatgac
<210>12
<211>432
<212>DNA
<213>Homo sapiens
<400>12
1 ttttatgtta agtcactttt gagatattta ttattagaaa ccatccaaca tgaaatatga
61 attattaaaa tgtttttctc catgtttcaa accagaaaca gtaattcaga atgcaactag
121 catcctaatt tttaaaatca aaataagatg accagattaa taaaacttag cattcacagt
181 attcaatcta gaaaaaatat aattaataga atgttaaagc caaaagaaca tttgaaagac
241 agaaagagag aaggggagga gagaaagaga gagggaaaag agaaagcaag aaagaggagg
301 aggaggagga ttgagagatg gagagtttga gattgagact tcttatgaaa tatattttaa
361 cggcaattac tcattaacaa ctgtgcattg agaatatttg aacatgttgt tnaaagctag
421 gggaaaaatg tc
<210>13
<211>501
<212>DNA
<213>Homo sapiens
<400>13
1 tttgaaacat gacacagcct tttattattt cagatcgtga gaccaggtca gaagggtcgt
61 tacgctcatc atgatactac tgctttgaat accacacaga ccagcgacat ttcccattca
121 tttccccaac cttgtgggaa aaattttcag gagtacagca tcaatgaaga acacagtgtc
181 atgaaacaca aatgctgtca cagatgacag tcacgttacc atgctgaatt gtccagagaa
241 gctaaccagt tactactcag ggctgatgta caatagatgc aacgccaaaa tgagatgaaa
301 gagaattcag aataaaattc cgtcccttgg agcatattcc attggctttc tctgctcctg
361 cttccgctgg tatctggcct tctggtagaa aatgatgatg gttacagtga ctatatttag
421 aagaatgacg agcagtatga gccagaacga gtatccgtaa ctgtgggtcg ttcctttact
481 ggtggttgcc gggtanagca t
<210>14
<211>607
<212>DNA
<213>Homo sapiens
<400>14
1 ttcagattta tttttatatt tattaagcag taagcaaaca gagttggggg agatgaccta
61 aaatggtttt cttttggaat aatatttttt aaaaaatcaa ataactgtta tcactttaag
121 ttgcatgagg ctgaagctgc acctggagag gaatttaatt ttcatgacat gcaaaactga
181 ttaggcagtg aactctttcc tcccgcttcc cctgaacaca tttataaact tcaacggggg
241 tgaattccat ctaatactct gaaaaccatt tctcatctca cagtttaccc aaatcatgtg
301 catgactgca agaggaaata aacaagaaat ctttaagcat agataagcca caatggatag
361 ttaatcttgt acagacaatc cagcattaag gctaatttga tcttttaaac attttatggg
421 aaacagctgt tgagttttct ctagaaaagc ccacaaggtt ccataacccc ataggcatac
481 agcctcgaca ggcagggctc catcaggctc ctcttgaact gggcactcct tcacggaagg
541 caggaatgca cgtgtcttca cttcctgctg ctctgcacgc acgtcacgat atctggcaga
601 aggtggt
<210>15
<211>502
<212>DNA
<213>Homo sapiens
<400>15
1 caattcttaa tcatttattt tcaacacgtg tactataaag aacctaagaa atcagacaat
61 tttaataacc cataaacatg ttgaatccat ttgcagattt aaattttgta aaaatagctg
121 tcactgcctc catatatcaa gtgtactatg tttataatca catttatgct accgatactc
181 ctcagaaaaa aacagattct gcttggttct agcttcagta tcatgaactc caataatgcc
241 ttgaggacct ccaaaggaaa aaaacagatt ctactaggtt ctagctgaaa tattatcaac
301 tccaaattga agctgaagta ttatcaactc caaataatgc ttcgaggacc tccaaaaaaa
361 agagattctg cttggttgta gctgaagtat tatcaactcc aaataatgct tggaggacag
421 caatgtagat gattttgtaa tcacctttca tcggagtgac cttatataaa aaataagtca
481 ataatttaga ggttctaagt ct
<210>16
<211>576
<212>DNA
<213>Homo sapiens
<400>16
1 tattcacccc tcccttgaag gtttaataga caacaggaat ctgggctctg aaaagtcaca
61 aacacctttc ccaagatgat gagcaactgc aacaactggc caaatgtgtt agcagcagaa
121 aagctgggca ttacctgtgt gagaggcgct cagcatgggc agtgaatggc cgtgagcagc
181 gcaccagcta catagcctcc acaccggaag ggtgctgctg ctctgcaggt ccgtttcagg
241 cgggatccag ccatccacag gaccaagggg ctggagtgtt gggaacagat gattctgtgt
301 tccacagata atggtacaaa gtgactgttc atagataagg tgtaagcaca gcatttgaag
361 acagctcctc cagatggtct gtctgttagt gaattcttaa gcacttagag ccttgaagat
421 tgagaaattc taaagaaatt ttttaaaagg aggagggtgg tagatgtcaa agacacaaaa
481 gctctttgta ggtgctgact ggctcacttt gtccccaggt tcatcttaga gctcaagcag
541 attcaagaca tgaggcagag atgctagact tgcgtc
<210>17
<211>450
<212>DNA
<213>Homo sapiens
<400>17
1 ggctagggcc agcctgctgc aaaccctaga gttcacaaca aaaccaccag ctctgcctac
61 agagccagtt ctttccttcc acacccacat gagctcacat accttttcca tgggatcctc
121 ttacagctgc tttcattcca gctaccagat ggggacttgt atgtggccga gcataaccgg
181 ctgtgaacaa gcagcactct gtctggggag cccagttcag catctgaacc cccaggctaa
241 agggagagct ctggagccaa cacagcactc agtggtcagg aagggggacg gtgcggcggc
301 ggcactcgct gcttctcacc tggcacgggc ctgcaatctg ggtcactgtc ctgagtgcgt
361 ggatatctca taaaccaaga gccatgcctg tgcctcgggg tgtggttgtg tacacgcggc
421 cacaagtgca cacggctaat ccagttttgt
<210>18
<211>562
<212>DNA
<213>Homo sapiens
<400>18
1 agagatttac aaagattttt atattaattt aataaaacaa attcttaaat agaacaaaat
61 aaacacctaa tgagccactt atatatagaa tgcttgtgcc cgttggctct cgttcttacc
121 ttgggccctc ttacctgcca aagcctacaa ggcccttaat tctaaagcca cccacccttc
181 ccacaaccat aaaaacgtac agtccagtga ccttggaatg caggatctgc cagaggcctc
241 cactacgtgg gcattaacac cctggctggg gtggggccct gtactgtagc cttggccttt
301 cattcagaca gaaaggctct accttctttc ctccccaaga agagacactc cctcatgact
361 gtcactcact ggcacaattc ctgcctctca gcaggcatca gctgacaact cccggccacc
421 cctgtggccc tcttgtggcc ctctctagaa gaacatgaag tcccagctct gtggcaacca
481 gagccatcct ttcttccacc tcccgctcag agagctctgc gtgaatgggc agcccggctg
541 gctgtgaggc gccagcacac tg
<210>19
<211>492
<212>DNA
<213>Homo sapiens
<400>19
1 ttttatatta agcaataaac tattcggttt attttaacat ttgagaattt cttttgtata
61 taaatgacat taaaagattc tcagaagaag aaaacctaag ctgaatggat taaaggctgt
121 ctgctgaggt gctctccccg ttggcttcag aaatggattt tggttaggta taataagttg
181 tggagtcctg cagaggttct ttacacattt ctcttctttt gagcagagag agcaagattc
241 tcctcttacg taaggaggca tatttgcaaa atttcctgca ggtccgtagt tgcatacaaa
301 tattgcagtt gaagctcccc caaggttagg acacattgca actgcacaac cgacataaaa
361 tgaattggcc caaactaact gtgtataatg gccacagact ctggagcatg atagactatc
421 aaaatcataa aattgggttt cattatacca agccgtaatg gcatgtcttg gtgtgaatga
481 ctttattcca cc
<210>20
<211>528
<212>DNA
<213>Homo sapiens
<400>20
1 tttttttttt ttaaaatata aaggaatttt atttatgaat gtatagatgt acagcaaata
61 ggaaagataa tacattaaaa gaacatatac tataaccagg tagagtttta tctcaggaat
121 ttaaggatgt tttaatatta caaaaaccct tattataatc atattaggca atttaagtga
181 taaaaatttg attgtatcaa aagacaccaa ttccttttat caagctttta gcttccaaca
241 aacaagaata gaagatgtta tttctgttat cctaacaaag aacatttgtt taaaaccaac
301 aattaacttc atatgtaatg aaaaaatatc aaaaaaactt attacaattt tatgaaacac
361 aaaaacaaaa tagaaatacc tatgatttta tatttagaaa gagcaaacag gccatctaaa
421 actgttagaa caaagaaaat caccaaaaga tacatatttt aaaagttaat agctttctaa
481 taatagagat tcccatgctg acagcaacat agatataaaa cagccaag
<210>21
<211>443
<212>DNA
<213>Homo sapiens
<400>21
1 tttttaagta agcacagcaa taaagtttta atggaatagc tttggcccag gcagaggcag
61 ttcccagatg tctcaggacg cgtgtgaacc ccaagaagtt gggggcgtta tctgggccct
121 tgggatccat tcccctgggt ataaagtgtt ggtacgtggc tccaggcctg gcccactcag
181 cctcccccag gaaggcttct caagtggaga aggttcttgg cctcagaact cacggcgctg
241 ctgctcacgc tgacccccca ctagatgcag atcggtgtag aaaggcctgc cagggcaggg
301 atgagggccc caagctggaa gcagcccaga aatcctttta ccagaggaca actccctaat
361 ccgctgggca ggggcggggt gtcacacgca ggattccgcg acgactgtca ctgcctcctg
421 ggcgcccctc tgtgcgggag cgg
<210>22
<211>474
<212>DNA
<213>Homo sapiens
<400>22
1 tttgttattc agaatatttt attttaaact acaaattagc acagctaatt tgaatattta
61 aatttccgta agcactgtaa attgaataca ttttttctta atgatatagt ttttttccta
121 aaaatcctag gcatattcag acttaattca aatgggttgt ctaaaaccag acaatacaga
181 tgtggagcca tttgtggtag atggacgtgt atatcttgca gaagtctcca atggccttaa
241 aaagcattat tattggacat caacttatgg agaatcttat gaccactcat ctaatgcagg
301 ttttgctctt gttccagtag gtcaacagcc atgaaaaagt agctgtaaaa taattttcat
361 acacttgtct tattgtttca cagagattaa tattctatag cctattttct tttataaatt
421 aaaacaagtt acttttttca aatgtgtaaa agataatgac tgtattaaac tttg
<210>23
<211>266
<212>DNA
<213>Homo sapiens
<400>23
1 tttttttttt tttttttttt tataaaccac cacagagctt acaaaataaa caaaagaaaa
61 attgaaatta taagttcaaa gagtaggttt taatttaata agctattggg tatttagggg
121 aaaaccaatt aaacttggaa ttgcattaca aatttgaaat tgtaatgaag caagtagctt
181 ttatgaaatt ggaacataaa tataatatca acaaaaacat aagaaattcc tattccaatt
241 aagtctcaaa atatttgttt tacagg
<210>24
<211>545
<212>DNA
<213>Homo sapiens
<400>24
1 ttttttttaa gtattgctca cttttactgt tctctcttag ggaagggcat tctcaaaacg
61 tttccgcaca agcagaccat cccttttatt ttccccgtct gtctcctttc cttctgcttt
121 caaaatgtct caagagtatt tacaagagtt gagcaacaca ggcatcttta tctggggtct
181 ttatccacag agcagaggac aggaagtcat cactacagag acgaagcgat gtatggtttg
241 acccagtgga ggactttgtt aaggtggagg tgtgagtgtg gagtgtaaac gtgggacatc
301 cagggcagtg gagggtaacc actggagagg aagtctgggg accagtttgg gagcagccaa
361 atataaaata agcatttctg ttctaaatcc aaatgaacat tctacgctgc tgtcatctcc
421 agtatacctc agagatccta aagtttcctg aagttgtttg gaagtcacgg ccgatgtaaa
481 gtgaaagcgc acacatatct gtaagctctg agctcaggat ttcacgtgag gtcctttgtt
541 cggga
<210>25
<211>724
<212>DNA
<213>Homo sapiens
<400>25
1 aaaccttaac ccagagttat ttttattttc cagaacgtgt taggaactag tacttaaata
61 atctcaagtc cctgaggggc cagagatccc accatgcaaa atagcaaaca gacccaagac
121 ttggggagag gcggtgagtg catcagaaat ggatgggtac atctgattcc caccacgcgg
181 ggctcagctt agttagcagg agaccttcag actgagaaaa aatgcaagtc tttttttggc
241 ctctaatatc tgggaaggat ggagggagct caggagacac agaaaagatg gcgtatgaat
301 cctgtccggc ctgaacgagg ctggagttgt gcctctggat agcttcaagc actgatcaga
361 ttgtcagccc ccgctgcttg aacagatgct ttagagcctc ttccagttgc cggtttgttc
421 cctgaagccc cttcaccacc tgcgctgccc actcgaagta ttcctggact cgatgttctg
481 accatccctc tggggtgcag cgattcaggt ccctcagatt gtacagcttg tctgccagct
541 tcaccagttt ggccccgggg ctactgtggn gcgcttggct cacctgcagc ctctntctct
601 ccagcttggg cagagtcttg tcatctggta cctnctncac caggcgccgc acttgtgccc
661 caaagtgtag cttcaccctc atccaggtgg tgtctgtgtc ctccaccgtg tcatggagca
721 gggc
<210>26
<211>544
<212>DNA
<213>Homo sapiens
<400>26
1 aaagctgact ttatttttat ttgaattggc caagtaaaat gttccataca aggcaaacag
61 ttcaacatga aatatttaaa ttaaaaataa attacttcca tcctatataa atctctagct
121 gccacataca aatgaaagat accagttata aatgaaataa gttaaaataa atggttgtaa
181 ggagctaggt gtggtggcat gtgcctgtca tcccagcttt caggagactg aggtgggagg
241 atggatctct tgaacccagg agtttgagac cagtctgggc aacacagcaa aatcctgtct
301 taaaaacaaa cgtaattgta ggatcctctg ttacgaccag cataggttac tggtttgctc
361 cctaactttg ttctggactc caacatctct attgaatgag acttttgaac agtcctctgg
421 gatagcccct tcttaaaaga gcacttgatg cccaggtctc caaatcactt tcagatatga
481 ggatctggtg ttcagagtct aaaacaatgg ttgaagagca gagatagcaa ggtggaatcc
541 caga
<210>27
<211>639
<212>DNA
<213>Homo sapiens
<400>27
1 tttttgcctg tgttatcgat ttattgcagc tccaatatga gtccactcct actcaaaccc
61 tgattctcag gggcctgggg aaggccaccc cactaggggc cctgtcccca ccagagcctg
121 gacatgggac tctctcccaa gcaggggtgt tgtccttcac aggggcttcc acgtctctcc
181 cgggcctgtc cgcactctgg gcagggctgg cacctggcta ttccctcaat ctgggccctg
241 gggccatggc aatgtggaat ggtccaggtg ttcatgtcag tggggcttgg ggacatggcc
301 atccacgtag aagttcctgg tgatcttggg cagggtgaat tccgctcctt ccagctccgg
361 tgtcagcaca atctggcagc ccagccgcga gttctcctgg aggagggggg ccatgtctag
421 catgtcgtct tccctctcct cgggaggagg caggagatcc aggtggtctt cactcacata
481 cacatggcag gtggagcagg ccagggaggc ttcacaggcc ccttccaggt ccaccccgtg
541 gcgctgggcc aggtgaagaa cattgtcccc gactctgcca ctcacttgga tccgctggcc
601 tgagcggtct acgaacacca cgttcaccac gtncccggg
<210>28
<211>489
<212>DNA
<213>Homo sapiens
<400>28
1 tccctgtcaa tgtgttctcc gtcactcctt acacacccag caccgctgac atccaggtgt
61 ccgatgatga caaggcgggg gccaccttgc tcttctcagg catctttctg ggactggtgg
121 ggatcacatt cactgtcatg ggctggatca aataccaagg tgtctcccag tttgaatgga
181 cccagctcct tgggcccgtc ctgctgtcag ttggggtgac attcatcctg attgctgtgt
241 gcaagttcaa aatgctctcc tgccagttgt gcaaagaaag tgaggaaagg gtcccggact
301 cggaacagac accaggagga ccatcatttg ttttcactgg catcaaccaa cccatcacct
361 tccatggggc cactgtggtg cagtacatcc ctcctcctta tggttctcca gagcctatgg
421 ggataaatac cagctacctg cagtctgtgg tgagcccctg cggcctcata acctctggag
481 ggcagcagc
<210>29
<211>537
<212>DNA
<213>Homo sapiens
<400>29
1 ttttttgtgg tggtcactgc tcagtgtaat gtgcagaatg atttgttttt tgtttttttt
61 tttttggtcc ttcattgcat cctgccatac ccatgagcaa acagtttggc attaattata
121 tatcactgcc accctctgaa ctttgaaaac tgccatcttc agacttggta taatggaaga
181 ggctttctct ctccaataaa ccttttgctt cagggtatac tcttcggttt ttttccagat
241 gtattatgta tgaactttgt actatgtata gccagagttt tatttatttt ttaaaaaaga
301 aactttttct tgataaagga ataatggtgg tctagctagt tcttgtaaaa gtgatgcctc
361 ttgaaaaaaa acagtcctat tcactagctt ttagtaaaag aatcagatct tttctttctt
421 gttaccttgg agtcttaaaa actgattgct aaggtgaaac aattcaatgc ataagtatgg
481 agctaagtgc cttttggagg atttcttgga agagcatcta tggagatact taaggag
<210>30
<211>469
<212>DNA
<213>Homo sapiens
<400>30
1 gctttcggtg aattaaaatg tatttggtgc cagtggtgct gaacatagaa taaaaaacag
61 aaaaagggcc cagacaggga catccaggct ggaggttgga gtggagcaca gtcagatgta
121 ttcacttttc tagcatgggt ttcaaagtgc gtaaggggag aaaacgcatc atggattgtg
181 ctgtgcatcc tggacaccgt gcgaggtgct catagctgtg atcttgtctc ccacaactct
241 cttgggtgac agacgtccac tgtccacatt ttatagacaa ggagaaaggg aagtcaaatg
301 tctcgtccaa gtctacacag ctaaaaaggg gcagaactag ggtgacgctc aggcctcatt
361 tagagatcgg gggttggcga gaagtggggt gggcttctgg aggggctggg agagccccac
421 aaggctgcag agggtggtga gcccggagtg ggcctggcct ggtgtgggc
<210>31
<211>496
<212>DNA
<213>Homo sapiens
<400>31
1 tttaaggggc gagagatttt aattaacaca aatggctgtg cctagtcttt aaatctgtcc
61 aaagcaaatg gagtgaaagc ctgctaattc ttcagtgctt catctggcaa tgacctcaga
121 aaaaagagtc tccctcctgt attatcaagc tgacttcctt tagttccttg ttgttctgtg
181 tagatctttg ttcccagaat tctcacatgg tgttcatttc tgccagtagt cactctgtcc
241 atagttgtaa tgcccatagt acatccaacg ttcaggtttt tctcagaaga gctcaaggaa
301 atgcttggga cccaggaaga tttaaaaatg cttgcattgg ctcaaaattc tgctgcaaat
361 acagtgataa tttcaggtca ttggccttct ggtagttctt caaggcttca attctcagct
421 caatcacttt gccatgaaaa tcattctgaa ggatgttatt ttgttcctga tacttgaccc
481 attccatttt cctctg
<210>32
<211>577
<212>DNA
<213>Homo sapiens
<400>32
1 aattttattc catttttaat attttggtct agcaacttgt gatacataga tgacaatttt
61 gtgagttttt caaatgtgtg tacagatttt tgtaaatatg actcttttgt aattaactca
121 tgtacagcct catcctgtat agtttaatga tgaatgtgca ggggacctgt ctcaggctcc
181 tatatggttc ctgggcctta tagccaggtt tgtgtggcgc tcccgacttt tgtgactgac
241 tggtgtcttc ccatttggac tgtggcctgg ccagagcccc ttgcatatcc ccactgtcag
301 gggcagccag gactgttccc atcctcctgg aatgggggaa ccttccttat cccctgccca
361 catcccctct ccaataaagc acctgtgccc tcagcaatgg cctgccatgt gctgntgctg
421 ggatgtttgt attaaggtaa gtgtgggtat atggttttga gaccgggggg tgttgaacat
481 tttggggaat ttattatggg gcatcttaag ggaagacatt ccttgcttct ctgaaggata
541 cagcctccag ggggagactg ccattgtggg taagtta
<210>33
<211>528
<212>DNA
<213>Homo sapiens
<400>33
1 aattgagaca gggtctcact atgttgctca ggttggtctg agtaatgata ttatcttgca
61 tttatgtggt gctttacttt ttgttacaca ttcacagtaa ttaacctcat ttgattttca
121 acatctctac aacagaggtt tggcaaatat tttttgagtg gctgctaagt ggcaatcatt
181 ccacaaggta tttttacatt tgttacttca cttaatcctt tcaacaatcc tgagaggtaa
241 gcatttgctt tacttaacag aggaggagac ggagactcaa ggaacttaaa tcttaaaaaa
301 aaaaaaaacc caaaacaccc aaaaacaatt atttatgttt tacagataag agactataaa
361 accaattaac aggtactttc accacatcag cttgtaagat gaaatggttt atcatcctaa
421 tgttagtgaa tgacagaggt gtgcagtctt acaaatgaca cactttgtaa gtcactgagc
481 aatgtttttc tgccataagg gattttgagt ccgagaaatc aggtcctc
<210>34
<211>577
<212>DNA
<213>Homo sapiens
<400>34
1 tttatgatat catagtcttt tgactttatt ttctgagatg gaaaagtata ggcataggtg
61 tttttaatag tcttcttgat gatatccttt agaataatct atcaaatggc ttctttcatg
121 tttcctgatt atcagcattc atcagtgtta ctgtcagcct tgattaagtg gttgaaaatt
181 tcagagaaga ataagcaact tctgtgaacc tttccccaat ccctgagaat cataatcatt
241 acagaaatat tttatccttt catcaaatat ctctggaaag tagccgtgtt cgttcattgt
301 taatagggca aggtgcagtg tcatagaggg ttaatccatg taaattggct tccacccgta
361 aagaaatttt ctgaaaatca cgaatgtaag tcaggaaaaa accaaagaag gaaaatgaca
421 tagaccattc tgctgcagta gtgatcatgt gaagcacata acctttgtcc tcggggttcc
481 aatggagttt ctgttctaaa tcagtcccaa aattgccact gtgcaaaact gatgagcaag
541 tcagcatcca caccagataa ccaacaacag tctgatc
<210>35
<211>465
<212>DNA
<213>Homo sapiens
<400>35
1 tttattttta ttctttttta tttaaaagat tcccttttta atctgttcca aagtgttgga
61 agctgaacta tacaagttcc tgccacccat ccttccagta cagttttctg aggacatact
121 ttttaaatgg aaaaataaca ggaggaccct ctaactgaaa ccaggtaggc ccagagtgag
181 ctcctcaggc ccctgtggca gcctggccaa agctggcctt tatggagcca gcgcgtggag
241 aagtctgggg aaccggggcc cttccttctg gtgaggaaag ggctgagcaa actcatgttc
301 tctttagtga aatggtccaa attcagatcc aaaagcctcc attatggcat tccctggcac
361 tcttcttata ctttatacat tgaaggcagc tccctctttt atggccagta taagcaggca
421 aagaaacaaa ggaatataga tacatatatg tgtatatata tatat
<210>36
<211>698
<212>DNA
<213>Homo sapiens
<400>36
1 ttttgtcaat tgagcagatt taatttccct gagattatat tccataagtg atacaaatac
61 taccccttag accaggggtt ttcaaagttt gctgtgcaaa aaatcagcta ggtatcttat
121 taaaatggtc cccaacatgt ctgagctgga gcttcagtgt tcacaggtct caggtgatgc
181 tgatgctact ggtctctggg tcacacttta aagaggaaga cattagataa agtaaaaggg
241 agtcatgang aaaagggtgc acctaaaaaa catcacataa caaaatacta aagtccccga
301 gtgggagaat acaaacatgt ctctctactc tatatctaag aatcagcnnt ntggttntct
361 atattnncac tgtgtctgat tataaagact atnttaagnt tatggggctt ttttaacttc
421 aaanntnaaa gtgctcccga ttttttaaat aaaacacgac tatagggctt tttagaactg
481 gggctgtctt ggagagtgaa ggacactttt gggagatcaa ctcttttgaa atttatttca
541 ctgctaaccc tcgataatat tgcttttttg aggctaactc cagagaaatt aattggctct
601 aaggcaaggg catttattat attaataaaa gnnnnngggc tcctcgaagc acttacatta
661 cataaaaagt tcacacattg gaaactantc ccaaaagc
<210>37
<211>688
<212>DNA
<213>Homo sapiens
<400>37
1 tttcttggcc tgcagcttca tttgcgagag cgccgaggca ggacacagag cacagctgtg
61 ctggaagtgt ggggagaacc cggacagctc agtcctgcca gcagccgcaa agagccgagg
121 ctgccaggcc catttatgtc cctcatgtct ctagattttc tcgtcaccca gcctcaaaaa
181 tatatgtgtc tgcaaccctc agtctctctg ccgtttcttg attcctttcc aaacctcagc
241 cggggccctg gcctcagccc cccgtccctg cgtctgctcc tcttcacagc agctgctgct
301 ggctcctccg cgctcggcgc caggccctgg gtcctcagac gcatcactgt catcagtgtc
361 cgagggcagc cgggtgctgg ccacaggcct gttggggttt ccaaactctc tccctgaatc
421 cacatcgaag ggatcgatct cctcctcctg ggggctctcc ttggcattgg ccaagaactc
481 ctgctccgcc tgcagcacct cctccgggct gccgcaggcg cgtactttgt ccaggagctg
541 cggttcaggt ccaagaagcc cttgccccat ttaaacttcc gcagcaaaat gacagcaagg
601 tctggaaagc ctacgatgca gaaggtgcag caaacgcttt cacgcaggaa agtctgtagg
661 ggcggccata gttcacggng ttgcgggc
<210>38
<211>544
<212>DNA
<213>Homo sapiens
<400>38
1 ttttatgtta cactgtgcat ttatttacaa agaggttgga gaaacacaca gaatctggcc
61 cccctttgca ctggggagtc accatcgtca taataaatac agtaatttta aaaaagaaaa
121 aaaatactag attggaacag ctgagggtca tcaggcttcc cccattccct ctcacaggga
181 gtgggggtca tgagatagaa accatcttcc ttcccctctt ctacctccga atcctccata
241 attgtccagg gatcgaagtg aaagagtcct tctttccagg tgttaccaac ccctacttga
301 ccctcaaaac ccccaaatca gtgctccttc ccttcccagg gcactctgca gggaccacct
361 gagtcagaca cagagtctct gaccagggtg ccaaggggat atcttaaggg tccagggaca
421 tggagggggc actttgtgaa tgagaggggg ccatagctgg gcaaggaaag gaggaatgag
481 agggctcatc aggaatgaga gggagagcgg tggaggggaa caaacagact aggcttctaa
541 acta
<210>39
<211>542
<212>DNA
<213>Homo sapiens
<400>39
1 taaaaatcat ttttctttaa tacaaaatca cataaagaaa ggcatgttgg ctaaatcaaa
61 tattcactaa atatcagtga agtcaccact ggaatctcaa tagcacattt tcctgctttc
121 ttttctccct tctgctaacc attgaagacc agggtcatcc gtgggagcag atgagtagga
181 cacgcgtctg cacactggag gccctggggg ttgacatggg agcaggaagt ggaccccccc
241 accctgcaca tcccttctgt ttttcttgat ttcagtctca ctggcccagg ccaaatcttc
301 aagggtgtct agttctgcag ccagggagaa agtgatgcca agagaacctc gtctcctccc
361 tcctcagtct gctttgaagg ggaaataaat acacaggcct agtgtgtctg tgtggcacag
421 ggaggtggtt ttgccaggca tcttggaagg ttgtcttcta gaatcagagc catagcctta
481 cttgtggcct tggatctagg tctgtttccc cgatcgaaaa aagaacagct gttttatgat
541 tg
<210>40
<211>542
<212>DNA
<213>Homo sapiens
<400>40
1 ttttttttag agttgtaatt taaatatttt attaaaatac atattacaag aaagctaaga
61 tttacaatga acagagttat gaagcttctc aactgtcttt aaacgtttaa caacacaaag
121 ggactagctg tcctcaataa agtaacacag taacaaaaca tgtaacaaat tattttaagc
181 acagtttaaa acaccctata gctaaaacac tcatactatg taaatccaca taaactctga
241 aagaagaggt atttttccac caccactcca aggaacacgt aaattggcat agctatatgg
301 tagtctcata tatgaagata aacaaatagt aatgcattat ttagtacata attattacac
361 acaaaaggta aggcacagct caagcttatc taataaaaaa tatttaaaaa tgacaattca
421 taattgcaaa caaaacactg aaagaaaaaa ttcggaagaa tttaataaaa ttttgaatat
481 ttacaaattg caaatgtgag tacttgttat aaaactactt acacccatgt agaatgtgca
541 tt
<210>41
<211>624
<212>DNA
<213>Homo sapiens
<400>41
1 tttgacaccc aagaccatcc tttattgtag tattagttca tggtaactgc atgaaaaaac
61 atttcaggag gaatttacaa tttccagctt aaagaacttg cccaccaaca taaccaattt
121 atgaaagtca attcattaaa aggtatagaa cctcttgttg ggcatgatgg caagggacaa
181 agctacaact tggcctgtgc ctttggaagc tgaggcagga ggaccatctg agcccaggag
241 cctgagacca gcctgggcaa catagagaat ccgtctcaac aaaaaaaaaa ttttagccag
301 gtgtgctgtg agctgtagtc ccagctacaa ggtgggagga ttgcttaggc ctgggtgatt
361 gaggatgcaa tgagctgtga ttgtgccacc acactccagc ctgggcaata cagcaagact
421 gtctcaaaaa aaaaaaaaaa aacccaaaaa aactcaaaaa tgtaatgaat gatacccaat
481 gtgccttttc tagaaaaagt tgccaaatat atctcttgga tctgctgagc atgtcctctg
541 atacataagg caagcatgtt tctacaccca gtgttgatgc cagttagttt tcagaatcca
601 aactgatggc agctactggt cctt
<210>42
<211>500
<212>DNA
<213>Homo sapiens
<400>42
1 cgtggtttcg tctatttatt aaaaaatatt tgagaacaaa acctctgcct ctttgagtct
61 tgctctggca tccccagcat ctctgattct ccctggtgcc cccagctcag gaagaaggtg
121 gtagtgggga gagagggtca ggggggcttg gcagggatgc aggcaccatg acttttgtga
181 ccagttccta gagacgcatg ggtgtagcct caggaggaaa gcgagaggag ctttaccatg
241 ggaacgaagg aaagggacaa cattgggagg caaacgttgg gagactagtc cagaaacttg
301 cagttgagga tacaacaggg tcctagtgtt tcctccctgg gtcagcgtag aagtagagct
361 ttttcactgt cgaaggcggg attgaagtta gagattgccc tggcagaggt tggggagaga
421 gggactagga ggtggtacat gaatgtcttc tctcattctg ctaggtccct ctcagtggaa
481 gatagatagg ctggtgggtg
<210>43
<211>475
<212>DNA
<213>Homo sapiens
<400>43
1 gttaaaatat cttttaattt taccggcaaa atacatcaat gactaatata ttcccgtatg
61 gaatatattc ttattggaat atattcttat atagaatata tagactatgt atatatacat
121 atgtgtatat acctatatac atatatatat cttggagata taaaactaat tgggaataat
181 gtcatatata tagatagtaa gcaaacattt tttaaaacat tttaaagact ccaaactatt
241 catttctatc cacctataaa aaactagcaa ttaaacctgt caaatcacag ccatcttgct
301 ttacgcagat tcagaagcat gagatccttt tacctttgaa actctagttt caaagctgtt
361 ctaaagtgac ttggttttaa tttatatact tgcagggata agaagtagct gtagggccat
421 aaaaatgtaa agaatacagt atcgtgccca tacacaactg caaacactta ttttt
<210>44
<211>487
<212>DNA
<213>Homo sapiens
<400>44
1 ttttttttgt tctcaacttg tttaatatgg aaaaaggtca tcaaaacggt aggcaggttg
61 ctgtttttaa tacattcttg ggatgttggc cattcagaca gcattatttc aaatatagat
121 gagttatcca actttttttg actcaaagat agtttgctta gatttttttt ttttgagatg
181 gagtcttgct ctgtcaccag gctggagtgt agtggcgtga tctcagctca ccgcaacctc
241 cgcctcccag gttcaagcaa ttctcctacc tcagcctccc aagtagctgg gactacaggc
301 atgcaccacc acacccagct aatttttgta tttttagtag agacagggtt tcaccatgtt
361 ggccaggatg gtctcgatct cttgacctcg tgatcagccc gccttggcct cccaaagtgc
421 tgggattaca ggcgtgagcc actgcgcccg gactagattt taacaagacc taattccatg
481 ggattat
<210>45
<211>493
<212>DNA
<213>Homo sapiens
<400>45
1 aactgttaaa aatgttttta ttttttagta agcaaaattt tacgaaaagt cagattcacc
61 cgtggagcca gaaccttctt tctcacggga agactgtggt accagtgcgt gttggtcggg
121 tggttcatca ttagtaagct cccgtgggcc agcggcagcc tgaccaccgc caccctcctg
181 gaggggcttt tcccacggga atccttatgc cggaagacaa agtctctgca ggcaccgaag
241 gagacagagg caatggggct cccaggggcc agttctcttt catcatctcg gtgctccccg
301 atgtggtcac agccatcttt atacctgttg atgagcacaa agttgaaggt ctgtccagtc
361 accccagaga ccgtgatccc ggatgcgctc tagactgggg atccagggct ttggaaccag
421 cgtgaggctg anaatgtggt aggtcagccc agcgtcgcca tacgttgcct gcttcctggc
481 acactgtgcc act
<210>46
<211>361
<212>DNA
<213>Homo sapiens
<400>46
1 ttgattttga taggaaagct ttaattggtg actaagcttt gtaaaaagga tgtaaacagg
61 ggaaagaatg aaaagaataa gatttatcta cataatgaag tttgactttt tacagtaaat
121 aaaataccta tttattaata tttccaaata ttaattagat ttaataatac tatatatttg
181 ttacaatgcc ttcatcagaa aatttaataa ttaagaagat acttgaagtt cattcaaatg
241 gcacttgcag aaatgcaact taatttctag ttctatcata tctgtctcca aaatggacat
301 atatgacagc aaaaacaaaa ttctctataa atctctccat tagttacatt actatgtaac
361 t
<210>47
<211>595
<212>DNA
<213>Homo sapiens
<400>47
1 agtttttaga aaaaaagaaa aaagtttaat agcgatatag aaaattgagc acctataaaa
61 ctatatggtg ggctctgggt tacattgagc ttaagtagac caagtatcta tcccacctaa
121 attatcagca actccaggcc atgacccagt gtcccattct ccttcacggt ttgctggtgt
181 gtagcctcct ggatacaggc aatgtatata gatcgcagag aatgtccgtt ctggcctctt
241 ccttggaagg gtctaaaaac agaccttaag gagctaagtg acttccccaa agcccacagc
301 tccagtgcca ctgctgactt ttgggtgggg gtgggatcag ttaaagagga aagctttcag
361 tactgtcagc acatacacct gccaattaag gggctggata gagttcatct ctaggagcag
421 gacctccacc cccaccctcc accccagaag ccatgtcatg ctgtttcacc aggatcttgc
481 ctgaggttag atgggagaga acagctacaa gcttgggtgg agtcactcat aaacacaccc
541 tgaaagctgt ggagcangga gagtgcangc tntagagggc tctncatgat ccctt
<210>48
<211>503
<212>DNA
<213>Homo sapiens
<400>48
1 aataattgct tgatttattg tacagaagtg tccacgggct cacaattcta aggacatcat
61 catgacagca agtaggaaaa aaaattaaag taattctttc accaattacc agtttatctc
121 ttctccaatt cctttggata cgcctcctgc aagaagccga tttccagttg tatgtgataa
181 tgaaagggtt tttctttctt acgttaaata caagcgaagt gattaactgg aagatagcgt
241 ctgattgcga ggtaatcagt gattcagatg gtgtgggaat ggcacctggg gatgggggag
301 gcaggacgga gatggaggaa gctggtgcag cctagcctgc cttgtgccaa ggacacccaa
361 gggcagaggg actgagctct gggggaggac agatttgaca taactggtcc agcctcacag
421 tttacaggtc ctggagggtg aggaaagtgg gagctggctg cggatgcagg acaagaaccc
481 agggcttccc ttcattttgc ctg
<210>49
<211>535
<212>DNA
<213>Homo sapiens
<400>49
1 ttttatttat ttaatttttg gagacagggt cttgttctgt cacccagact ggagtgcact
61 ggtatgatca tagctcactg taacctcaga cttctgaggt caagtgatcg tcctgcctca
121 gccttctgag tagctaggac tccaggtgtg catcaccatt cccagctaat tttatttatt
181 tatttatttg tttgtttgtt tgtttgtttt tgtagagaca gggtctcact atattgctca
241 agctggtctt gaactcctgg gctcaaacaa tcctcccacc ttggcctcct aaagtcctgg
301 gatcacaagc atgagccacc atgcccaacc ttttctagtt tttaaatttt catacatatc
361 tattagatgt ttatagtgta aggttgaact ccattctttg cttctctgtt gctggtaaat
421 ttttgggtat atttttacga attttgcaca ttcttttaca tattggtaaa ggaacagtct
481 gtgatctgga tttattcaga tccttattca gaattaccaa ttgttttatt aatca
<210>50
<211>397
<212>DNA
<213>Homo sapiens
<400>50
1 tttttttttt tttttgttca ctagtttttc ctttattttc ttgggtatac ttaaatagct
61 actttaaagt tctattatta atttctatta agaaatgctg ggtctttttt tttttttttc
121 cttgattatg ggtcaaattt tcctgcctct ttgtatggct agtaattttt taattgaatg
181 gtaggcattg ggaataatac cttgtaaggc atctggctta tgttatcttc ctttaaatgg
241 tattgtttta tttcttgtta aagaggatta tttctgtttg aacttagtca aatgtggtcc
301 ataggctggc tatttttgta aatgaagctt tattggatat agccatgccc atttgtttaa
361 tattaatata ttatctggct tcttttgtgc tataata
<210>51
<211>535
<212>DNA
<213>Homo sapiens
<400>51
1 aggttttttt ttttttaata tttttaatgt ttaatagtta aaatttttta acaatttaac
61 tttaaaaagg tcacacattt tctgatccag caatgcccca atcagattgt ttcattttat
121 tattattatc aacactgtcc cctttttggc acctgtaaaa tagttccttt cgggagtttg
181 gagccaggcc aggcaccgtc ggtgcatggg atgagatggg caggtttgga gctcctctgt
241 ctagtgagga tcacggtctg cagagaaggg ttggcctccc cgtctcctat caaggcttaa
301 agcaaggaga accatcccaa atttggttcc ttttccccta agtatcctta gaggcaatcc
361 accctgtgac taggtgacta ggtgaaggac tgaggtccag aaaggagcta tcttaaacct
421 ggaatcccat ttcctagtct gcagccttaa gcagttaccc tctcagacaa ctagccctct
481 ccttcctccg catgaaaacc catggcttac agggatggtt gttgctttcc ctaaa
<210>52
<211>545
<212>DNA
<213>Homo sapiens
<400>52
1 tttttttttt ttaattttga aaagactgtt gatgtcactg tggtttatta ggtaaataca
61 aagtataggc tcttgcattt tttaaaaagc aaaaccaaag agattagaaa ccaagtacac
121 atatcctcta gaagagaaac ataaatcagt tttaacaatt aggcacttaa aaatgtaaat
181 gtaagacaac attatagaag tataaactat agttacactc ctaaattcct cctgaaatgt
241 ttacaaacac aaaatcacaa gcatggaaaa caaatttcct ctttatcaaa aaaggaacct
301 gaatttgaat ccaatgtgat aaaccaatga ttaaggtact ggtgggtagg aaaaaagagc
361 ttctgaaatt tacatatttg attaaaatgt aagcatttca taaaactatc acaatagcat
421 acagtagata tcataatgaa aaatatatgt caggaaaata atgaatctag acttaaaatt
481 ttactttaca acaaggcact taacacattg aaacagtaca gtaaatttcc aaaagaatgc
541 aattg
<210>53
<211>516
<212>DNA
<213>Homo sapiens
<400>53
1 aaaacaaacg ttcttctttt aatacagcca ttgaaaagat gacacattaa gaaacatgta
61 aacactgcag ctgcttaatt acaagttgca ctgcttgatt tagtacctat gcactcccag
121 gtttggggac cttaagagag ggggacagga gcctcccctc actttcacag ttggatagag
181 aaggcaagaa tgtgggtaga gtaagaaaga gaaaacagaa gacctggctt gtgcacagcg
241 cctgagagaa tcaaagcaaa ttctgtcttc taagtcctcc cagaagaaag gtttaagatg
301 ttaggaaggt tggaaaatga acgtgtgttg tcagttggga ggcaaaggaa ttgacaaatg
361 cttctagtta gaatatcagc taggaaaagg agggatacag agcctgacct catgctctga
421 aaaggcaagg aacccagaac ttgcctccct tatccactta agccccaacc ttgatcatca
481 agggcagcgc atgggtgatc ctgttcccat gaggat
<210>54
<211>571
<212>DNA
<213>Homo sapiens
<400>54
1 gaatgatgct tttttttatg atcttaatta cattaaagga tttaaaaaat gccactgatc
61 tcacagttta caatatccaa atcttcaaac ctgctggaag aagtccacag cacagcctgg
121 aaattgcatc cgttgcattc tctcgtgcag ttaccttctg ccttgatatg tagtcagttc
181 ttcctgaagg atggaagctc tcttttgcag aaaattaacc tgtgatttta gggaggaaat
241 ggtgtcttca ggttcttgtc ttagggatgc tggcatcaat cctttcaatt ttgtttcata
301 ttcttgtcgt atgtaagtta tctgttcctg tgactccaat tctttgtgtt gtaatttttt
361 ctctgcacat cgcacctgat tagaacggtt ttctaattca tcttgtaaaa ccttgattgc
421 ttggtcatta tctctaatca gctgcttctt ctcatcttca aacttttgtc taacatcctg
481 gagccgcctt tctgcagcaa gctgctgctg gctgttctct tctttcagag aggaaatggt
541 tgtctgaagt tctgctatga tctgtgaaga t
<210>55
<211>1711
<212>DNA
<213>Homo sapiens
<400>55
1 tttttttttt taaatctaag ctattcccat ctcccccatt ctatgctggg gtgatatacc
61 acaagaagtt acaggaacaa ctgctaaaag aattaaacat cttgggcctt tacacagctg
121 ttgctatatc atggctttgg tgcatggtcg gtcacagatg ctgtcaagag gcttatgttt
181 agttatcctt ttgcttcccc aacccccaca ttaaaggtct ccttcacctt ctctgtcctt
241 tttgctacct cccttcttcc tgctccaagc tcccacaaac cagccttaat aaaagaggaa
301 ggatcaaggc aacactccac atcagtcata tttcagggca gcttgatgtt tgtttgctaa
361 tagatggttg gtattatcta accaataggg tgactccaag ttttaaaaaa cagcaagact
421 aattcagaaa taatattatt tcttaatttt tttaaaaata gagatggggt ctcactttgt
481 tgcctaggct ggtcttgaat gcctaggctc aagcaatcct cccaccttgt cctcccaaag
541 tgctaggatt acaggcgtga gccattgcac ccgggctctc agaaatctta aaaaggattt
601 agtttcattt aaaaataaca aacacagttc cccaaatctg aaatttagtt attgaaactg
661 gaccatgttg tccatggaaa acatatctta ctttatacca gattttaaaa ttaacactgg
721 tgtaagtgca gcctaaaatt cctctgagcc ccacttttac ataagaaaaa ttattgaata
781 tgataaaggt agcatttcca atcagtgaga aaagataggt tattcaattt gtgttgggac
841 tggtggatat atatctagga aaaaaaagta cagactctaa atattgaaag gtaaaactga
901 aaacataaaa atatttgaag aaatcactgg aaaattattc tacaaactgc atggggaatg
961 acagtctgtg ataatagtaa ccaagaacca tgaaagaata gattggtaac aattcagcta
1021 cataaaaatc cctaaatttc tctatggcag aaaccatgaa acagataaat ttaccaaact
1081 ggaaaaaatt ttcacaaatc atgtcacaaa gagctaattt tcttaaaata tataaaaaag
1141 atctttcaaa gtgtcataca caaaacactg cttttcgaaa aacataagct cctacaaagc
1201 agtaagaaaa tgatgaacaa atagaaaaat gggcaaaggt gatgatttaa cagttcacag
1261 agaaatacaa atggcttcta aaatatataa aaagatgccc aacttcgttc ataatatgaa
1321 aaatgtaaat taagactaca ctaagataca atttttcaca gatctgtttt ctaaaaataa
1381 aataagcttg agagagagcc tcttatctga attctgggac agcctgattt gcatgaggga
1441 aataggcatc ctcctgcact gctggtggga gggtaaaggt acagtctcag tggaggacag
1501 tttgctgtta cctctcagaa ttacaaatgc atgtgtttgt tttgatgtag caatttccca
1561 tctaggaatt tattcttgaa agacagtcat acaagatttt cacaccagca ttatttgtaa
1621 tagcaaaaag atgggaaatt acctaaatgc tcatatatag gggactgcta aattgtggaa
1681 ttccatgcaa ttctaaaaaa aaaaaaaaaa a
<210>56
<211>1720
<212>DNA
<213>Homo sapiens
<400>56
1 aatacttttg atcacttcca tttgcctgca aagccagaaa cttctctcaa gaagattata
61 gctgagtatg taaaacaaaa tatatgtaca actgtaatac caacaagcac agtggtaagt
121 tataacaaga tatacgaagt aatagaaatt aagaagtgag agtatcttca ggcgaaggca
181 actgggaagc tggagctcaa agtttaaggc tgtgttaaaa cacaacctaa agttcccagt
241 agaagcttgc tatagacttt tggtggctct gagaattccc ctggtcacct cagtgtgagg
301 ggtgggtgat tcttaacctc tggtgggttt tgttgcagtt tagctgctgt ggagggattt
361 cctacaagga ctggtctcag aacatgtatt tcaactgctc agaagacaac cccagtcgag
421 agcgctgctc tgtgccttac tcctgttgct tgcctactcc tgaccaggca gtgatcaaca
481 ctatgtgtgg ccaaggtatg caggcctttg actacttgga agctagcaaa gtcatctaca
541 ccaatggctg tattgacgag ttggtcaact ggatacacag caacctattc ttacttggtg
601 gtgtggctct aggcctggcc atcccccagc tggtaggaat tctgctgtcc cagatcctag
661 tgaatcagat caaagatcag atcaagctac agctctacaa ccagcagcac cgggctgacc
721 catggtactg agaatccatc ctgcacctcc tcaccatgga aactggcaag cctcataaac
781 gaacagcagt gggtgctgaa agcagcacca aatggagatt tggattccag ccccccagtg
841 acagcccagt gggaagaagc aaactccaga tgggcagaag gcagggtgca caggtggctc
901 cagtctcagg aggatgcgcc tcctctcccc catcccagcc ctcagcattg tgccagagtg
961 atacccttaa gtgtttgggt ttatgttttc agttttgttt gggaaacagc agttgcacag
1021 agagttgggg gtactgctgc tgccttttca ccgaggcact gccaccacca gctctagcag
1081 gggtgctcct gagcttggcg gacatactta gatcctaacg tgccagtgag acctggctgt
1141 ggagagtagc actggcagcc ctgcctggac tccacttggc atgataccag ctccagaagg
1201 gaagggagtg gagcaggcag tgaggagaga gcctgggggt cggctgggga cagccgtatg
1261 tgctaggtag gagtggaggg agatatgttt accaaatgcc tgtcctgcca tcctcccagg
1321 tagtcagagt gagctacatc ctgccccacc ttcatttcca tggaaacacg gcagctagga
1381 cacggggtac aacagcagcc aaattcttcc ccacctccct tacttcgaaa aaaagtttgg
1441 aaccctggtc cctatactct gcagtcagaa gtgggactga gccatacatg cccttgaatt
1501 cctccctgtc tggccctccc tctccagcaa gcagggtttt ctttaacttg gcagtgtgca
1561 gaggagaagt ggtaacaccc ccaccccatt cccctgcatc ggggctcagt attcctacag
1621 ggtaagaggt aggaatcttg ctgggacgag gggagccaga agtggcaata aaagcgtgtt
1681 gacctggaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
<210>57
<211>653
<212>DNA
<213>Homo sapiens
<400>57
1 tttttttttt ttttttgcat acagaattat tttatttaac ttaaaccatg tagtacttta
61 ctagaaaaaa gcagagtaag agaaactaac gttgccttag cttcagccat tcaaaataga
121 cagtttcttt tttccattat gtaaagaatc cagagtatat cgcaataaca ggaataaatt
181 cttacaacag aatatacaaa aacattttga aatttttttc atctactgat tttttatata
241 aacaggattt tttaggaata atttatacac agaaagtcat tttatgtaac aaattggcca
301 tgttattacc tttttttttc ttacttaaaa aaattttttt ttaacaagaa aactcagaaa
361 atgcattatt tgcggtgcat ccattccatc ccgccttctg gtttgatttt ttttatccca
421 gacaaaggga tacccagagg tagacaaact ctggcaaacc tctcacctca acctcactgg
481 cttaaaaagc agacaggtgt tttcaccggg cgtctcttcc accggtggat gtgtgtgtgc
541 aacgccaaac atccaaatga aaagttgaaa acaaaaccca aatagtttcc agatctttct
601 cctatgtagc gcaaaaaccc caggtgtttc ccatgataga gatattgtgg agt
<210>58
<211>1037
<212>DNA
<213>Homo sapiens
<400>58
1 ttatttchcc gabctccact ctggctccca ccccacaagc gtcagagcag gaaacaagct
61 tggstgagat gcctcaggcc tggtaacctg aggtgtagag cacccagaag gaagggtaaa
121 agcagggggc aaagcggtgg ccctcccttt ctgggggtca cttctgggct ggggccagct
181 gaaacctgtg tccaagtagc tttcagggct ggccacaccc taagccttgc aaaagggcct
241 cctgcaaggg ctggcccatg gggtccccac cttcccagcc agtgaggtta gcatggttag
301 gagtccacat gtgtgcaagt gcttgtgtgg aggctcatgt atgcatgtgt gtatatgcaa
361 agctgcacat gacaatgtgc atgccagtcc agagttagat gtacctatgc agttgccctc
421 aagcgaaggg tcatatttgg aaacaaggat ggctctaaac atgtaagcgt gcatgtgggc
481 atgtatgtat ctggggccta aggaggtggg gaagtgggtg ttggggtaag ggctggcctt
541 cagggcattt gcagaaggag gagtgggtgg gagggaaagg ctgggcagag caggggaagg
601 agtgaaagcc aggcaggaaa gtggaagaac aggagaagct catgtaatgg attaccctcc
661 acaggattat gttccttgat tcctgagagt tttttctctt gattttaccc cctcagtcta
721 tcactgcaag agaaagaggt agaaaagaca aacagaccac aaaagacaag aacccagaca
781 tatagacaga cgcacctgtt gcatgtgcat gagccagagc ctgggagaga agagagagcg
841 tgcaagagag agctcagagc aggcaggcag cccacccctg cagcagtgct gggctyactg
901 gagccctgca gragtcagca gccctgtatg cactcctctg gtttgtcagg taacaggggt
961 gcccgccccy tcatgatcag caccggkggt ggggagctgc ttaggtgctc aaryggtctg
1021 accatgggkc tggtctc
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