Platinum (2) complex and antitumor agent containing the same as active principle
专利汇可以提供Platinum (2) complex and antitumor agent containing the same as active principle专利检索，专利查询，专利分析的服务。并且NEW MATERIAL:Platinum (II) complexes of formula I [-B-B- is group of formula II and III (n, m, 1 are 0W3; R
1 , R
2 are H, alkyl, aryl); at least one of A
1 , A
2 is group of formula IV and the other is formula IV or Cl
- , Br
- , I
- ].
EXAMPLE: Pt(D-gluconic acid)H
2 O(cis-1,2-diaminocyclohexane).NO
3 .
USE: Antitumor agent: these complexes attack DNAs in the tumor cells and show very high antitumor activity. Moreover, they cause less nephropathy.
PREPARATION: For example, a compound of K
2 PtX
4 (X is halogen) is made to react with a diamine of formula II or III to give a compound of formula I (A
1 , A
2 are X). Then, the product is made to react with silver nitrate to form a compound of formula I where A
1 , A
2 are nitrate. Further, sodium D-gluconate is made to act on the compound to give the compound of formula I where A
1 , A
2 are D-gluconic acid.
COPYRIGHT: (C)1982,JPO&Japio，下面是Platinum (2) complex and antitumor agent containing the same as active principle专利的具体信息内容。
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