IMPROVED METHOD OF MAPPING GLYCANS OF GLYCOPROTEINS IN SERUM SAMPLES
专利汇可以提供IMPROVED METHOD OF MAPPING GLYCANS OF GLYCOPROTEINS IN SERUM SAMPLES专利检索，专利查询，专利分析的服务。并且The present invention relates to a method for analyzing glycans of a recombinant glycoprotein in a liquid sample of a mammal. Specifically the method comprises a step of affinity purifying the recombinant glycoprotein from the sample, enzymatically releasing a glycan containing fragment from the immobilized glycoprotein, adding a reference standard containing isotopically labeled glycans, fluorescently label the glycans and analyzing the glycans using LC-MS. The present invention also relates to a method further comprising analyzing the glycans of the immobilized recombinant glycoprotein fragment, further comprising a pre-clearing step of the liquid sample, and releasing the glycans from the immobilized recombinant glycoprotein fragment. The methods allow for the use of a small sample volume and the possibility to operate with high throughput, such as in a 96-well plate sample preparation and are therefore suited to measure pharmacodynamics parameters of a recombinant glycoprotein in a mammal in clinical or pre-clinical studies.，下面是IMPROVED METHOD OF MAPPING GLYCANS OF GLYCOPROTEINS IN SERUM SAMPLES专利的具体信息内容。
| 标题 | 发布/更新时间 | 阅读量 |
|---|---|---|
| 抗IL-17抗体/TNFR ECD融合蛋白及其用途 | 2020-07-07 | 0 |
| FGF21突变体及其用途 | 2021-03-06 | 2 |
| 调节性多核苷酸 | 2020-06-16 | 2 |
| Platelet-derived growth factor compositions and methods of use thereof | 2021-05-26 | 0 |
| 脂質キナーゼおよびmTORのデュアル阻害剤としてのイミダゾキノリン | 2022-03-05 | 1 |
| ESTROGEN RECEPTOR ALLELES THAT ARE PREDICTIVE OF INCREASED SUSCEPTIBILITY TO BONE FRACTURE | 2021-09-02 | 1 |
| METHOD FOR RELIEVING CHRONIC PAIN | 2022-05-23 | 1 |
| STABLE LIQUID READY-TO-USE INJECTABLE FORMULATION OF BORTEZOMIB | 2021-02-18 | 0 |
| GASTRIC RETENTION ACTIVE DELIVERY SYSTEMS | 2021-02-11 | 1 |
| IMPROVED METHOD OF MAPPING GLYCANS OF GLYCOPROTEINS IN SERUM SAMPLES | 2022-06-01 | 1 |
高效检索全球专利专利汇是专利免费检索,专利查询,专利分析-国家发明专利查询检索分析平台，是提供专利分析，专利查询，专利检索等数据服务功能的知识产权数据服务商。
我们的产品包含105个国家的1.26亿组数据，免费查、免费专利分析。
专利汇分析报告产品可以对行业情报数据进行梳理分析，涉及维度包括行业专利基本状况分析、地域分析、技术分析、发明人分析、申请人分析、专利权人分析、失效分析、核心专利分析、法律分析、研发重点分析、企业专利处境分析、技术处境分析、专利寿命分析、企业定位分析、引证分析等超过60个分析角度，系统通过AI智能系统对图表进行解读，只需1分钟，一键生成行业专利分析报告。
