RECEPTOR INTERACTING PROTEIN 2 IN DEVELOPMENT OF IMMUNE RESPONSE
专利汇可以提供RECEPTOR INTERACTING PROTEIN 2 IN DEVELOPMENT OF IMMUNE RESPONSE专利检索，专利查询，专利分析的服务。并且RIP2 is a protein containing an amino terminus serine/theronine kinase domain and a carboxyl terminus caspase activation and recruitment domain (CARD). RIP2 plays important roles in three major signal transduction pathways, involving both innate and adaptive immune responses. First, RIP2 is required for IL-12-mediated upregulation of IFNg, as shown in both Th1 cells and NK cells. Second, RIP2 is involved in Toll-like receptor (TLR) signaling. RIP2 knockout mice are more resistant to endotoxic shock after challenge with bacterial lipopolysaccharide (LPS), which signals through TLR4. RIP2-/- macrophages are impaired in NF-kB and SAPK activation, as well as cytokine production in response to LPS treatment. Third, RIP2 is most likely the key kinase in mediating signals through intracellular receptors such as the NOD family proteins. NOD proteins contain CARD(s) at the amino terminus, a nucleotide binding domain in the middle, and leucine rich repeats (LRR) at the carboxyl terminus. The LRR domain is involved in the recognition of intracellular microorganisms such as bacteria and parasites. The CARD of NOD proteins can directly bind to the CARD of RIP2. Intracellular microorganisms may trigger the aggregation of the NOD/RIP2 complex, and activate innate responses. RIP2-/- mice exhibit increased susceptibility to infection to the intracellular bacteria Listeria monocytogenes . These data demonstrate that RIP2 functions in both innate immune responses and Th1-mediated adaptive immune responses.，下面是RECEPTOR INTERACTING PROTEIN 2 IN DEVELOPMENT OF IMMUNE RESPONSE专利的具体信息内容。
| 标题 | 发布/更新时间 | 阅读量 |
|---|---|---|
| 一种角馈式宽带高隔离度双极化天线 | 2020-05-08 | 134 |
| 一种芯片封装结构的制作方法 | 2020-05-08 | 560 |
| 一种治疗坐骨神经痛的中药 | 2020-05-08 | 216 |
| 一种天线单元及MIMO天线和终端 | 2020-05-11 | 722 |
| 茶蒲直接用于饲料中的使用方法 | 2020-05-11 | 643 |
| 一种青蛙饲养方法 | 2020-05-11 | 291 |
| 一种阵列基板和显示面板 | 2020-05-11 | 796 |
| IL−4Rアンタゴニストを投与することによるアトピー性皮膚炎を処置するための方法 | 2020-05-08 | 69 |
| 毒素遺伝子及びその使用方法 | 2020-05-11 | 932 |
| ロバストなAM−PMひずみ自己抑制技術を備えた超小型のマルチバンド送信器 | 2020-05-11 | 328 |
高效检索全球专利专利汇是专利免费检索,专利查询,专利分析-国家发明专利查询检索分析平台，是提供专利分析，专利查询，专利检索等数据服务功能的知识产权数据服务商。
我们的产品包含105个国家的1.26亿组数据，免费查、免费专利分析。
专利汇分析报告产品可以对行业情报数据进行梳理分析，涉及维度包括行业专利基本状况分析、地域分析、技术分析、发明人分析、申请人分析、专利权人分析、失效分析、核心专利分析、法律分析、研发重点分析、企业专利处境分析、技术处境分析、专利寿命分析、企业定位分析、引证分析等超过60个分析角度，系统通过AI智能系统对图表进行解读，只需1分钟，一键生成行业专利分析报告。
