| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 121 | 12alpha-deoxytetracycline oxidation process | US20834362 | 1962-07-09 | US3188348A | 1965-06-08 | KENNETH BUTLER; WOODWARD ROBERT B; GORDON PHILIP N |
| 122 | Substituted 6-deoxytetracyclines and 6-demethyl-6-deoxytetracyclines | US10294361 | 1961-04-14 | US3219671A | 1965-11-23 | HLAVKA JOSEPH J |
| 123 | 7- 디메틸 아미노-6-데메틸-6- 데옥시 테트라사이클린 염산염의 회수 방법 | KR1019730000321 | 1973-02-24 | KR1019760000303B1 | 1976-06-26 | 마아틴토부크스 |
| 124 | 可同時進行光催化產氫及降解環氧四環素之材料的製作方法與其應用 | TW108104359 | 2019-02-11 | TW202030019A | 2020-08-16 | 張章堂; CHANG, TANG-CHANG; 田晶晶; TIAN, JING-JING |
| 本發明供了光催化產氫及降解型銅-硫化鉻(Cu-CdS)材料製作方法，並可使用此材料同時光催化產氫及光降解環氧四環素。本發明使用水熱法合成硫化鉻(CdS)奈米材料，然後利用光沉積法合成Cu-CdS，在紫外光下進行光產氫及光降解土黴素oxytetracycline (OTC)，頗具廣泛的應用前景。 | ||||||
| 125 | 可同時進行光催化產氫及降解環氧四環素之材料的製作方法與其應用 | TW108104359 | 2019-02-11 | TWI692375B | 2020-05-01 | 張章堂; CHANG, TANG-CHANG; 田晶晶; TIAN, JING-JING |
| 126 | Process for the production of alpha-6-deoxytetracyclines | US552839 | 1990-07-12 | US5049683A | 1991-09-17 | George Krsek |
| A process for the preparation of alpha-6-deoxytetracyclines from the corresponding 6-methylenetetracyclines is described using a silica-supported heterogeneous rhodium catalyst: ##STR1## The process stereospecifically produces the alpha epimers at higher yields while using lower rhodium metal levels than prior methods. | ||||||
| 127 | Process for the preparation of .alpha.-6-deoxytetracyclines | US858660 | 1986-05-01 | USRE32535E | 1987-10-27 | Ivan Villax; Philip R. Page |
| An improved process for the preparation of .alpha.-6-deoxytetracyclines and more particularly to the stereo specific hydrogenation of the 6-methylene group of 6-deoxy-6-demethyl-6-methylene-5-hydroxytetracyline and of its 11.alpha.-halo-analog, is described in which the catalyst is the reaction product of a rhodium salt or a complex with a hydrazine or salt thereof. | ||||||
| 128 | Process for the preparatin of .alpha.-6-deoxytetracyclines | US772923 | 1977-02-28 | US4207258A | 1980-06-10 | Renato Broggi; Gino Cotti |
| A process is provided for preparing alpha-6-deoxytetracyclines depicted by the formula: ##STR1## wherein Y is H, F, Cl, Br or I; and R is H, OH or --O--CO--(C.sub.1-6 alkyl);which comprises: contacting a 6-demethyl-6-deoxy-6-methylene tetracycline or salt thereof having the formula ##STR2## in which Y and R are as given above, with hydrogen at a temperature of between 15.degree. C. and 80.degree. C. in the presence of a catalyst soluble in a polar solvent, said catalyst being a complex of rhodium with electron donor ligands of a tertiary phosphine selected from the group consisting of triphenylphosphine, tributylphosphine, triethylphosphine, diethylphenylphosphine and diphenylethylphosphine and said polar solvent being a mono- or polyhydric alcohol with from 1 to 4 carbon atoms, N,N-dimethylformamide, N,N-dimethylacetamide, dioxan, tetrahydrofuran, methoxyethanol, ethoxyethanol, acetonitrile or pyridine. | ||||||
| 129 | Preparation of alpha-6-deoxy-5-hydroxytetracycline | US47379174 | 1974-05-28 | US3907890A | 1975-09-23 | SCANIO CHARLES J V |
| A process for the synthesis of Alpha -6-deoxy-5hydroxytetracycline, a broad spectrum antibiotic, by reduction of 6-methylene-5-hydroxytetracycline using cobalt carbonyl, triphenyl phosphine and hydrochloric acid in a reaction solvent and inert atmosphere.
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| 130 | Tetracyclo epoxy ether monomer and compositions | US3472796D | 1960-05-31 | US3472796A | 1969-10-14 | TINSLEY SAMUEL W; STARCHER PAUL; MCGARY CHARLES W JR; PATRICK CHARLES T JR |
| 131 | Process for the photooxygenation of anhydrotetracyclines | US23025262 | 1962-10-12 | US3269929A | 1966-08-30 | VON WITTENAU MANFRED SCHACH |
| 132 | Therapeutic composition comprising tetracycline and a dioxolane | US80457759 | 1959-04-07 | US3004894A | 1961-10-17 | JOHNSON RICHARD H; WALLACH DONALD P |
| 133 | Recovery of 6-deoxy-6-demethyltetracycline | US84335759 | 1959-09-30 | US2999111A | 1961-09-05 | STEPHENS JR CHARLES R |
| 134 | Hydroxylating 12alpha-deoxytetracycline with ascomyceteae | US3488660 | 1960-06-09 | US2970087A | 1961-01-31 | DONALD BECK; SHULL GILBERT M |
| 135 | 신규한9-아미노-7-(치환아미노)-6-데메틸-6-데옥시테트라사이클린 및 그의 생성 방법 | KR1019920018123 | 1992-10-02 | KR100261528B1 | 2000-07-15 | 조오지프제이라브카; 파이크-엥섬; 야코브글루즈만; 빙제이리이 |
| 테트라사이클린에 저항하는 유기체를 포함하는 넓은 스펙트럼의 유기체에 대해 활성을 가지는 신규한 9-아미노-7-(치환 아미노)-6-데메틸-6-데옥시테트라사이클린이 공개된다. 본 발명의 신규한 화합물을 제조하는 중간체 및 방법이 또한 공개된다. | ||||||
| 136 | Process for the production of alpha-6-deoxytetracyclines | US263728 | 1988-10-28 | US4973719A | 1990-11-27 | Jagmohan Khanna; Kiran Bala; Inder P. S. Grover |
| A process for the hydrogenation of a 6-methylenetetracycline in the production of alpha-6-deoxytetracyclines, particularly the antibiotic doxycycline, in the presence of hydriodotetrakis (triphenylphosphine) rhodium (I) as a homogenous hydrogenation catalyst. The desired alpha-6-deoxy product is produced in high yields and stereospecificities, the process requiring the use of minimal quantities of rhodium metal in the hydrogenation catalyst per mole of the 6-methylenetetracycline hydrogenated. | ||||||
| 137 | Process for the preparation of .alpha.-6-deoxy-tetracyclines | US641607 | 1984-08-17 | US4597904A | 1986-07-01 | Philip R. Page |
| A process for the preparation of .alpha.-6-deoxy-tetracyclines by the stereoselective heterogeneous hydrogenation of a 6-demethyl-6-deoxy-6-methylene-tetracycline or an acid addition salt thereof, in the presence of a tertiary phosphine, or the simultaneous dehalogenation and stereo-selective heterogeneous hydrogenation of an 11a-halo-6-demethyl-6-deoxy-6-methylene-tetracycline or an acid addition salt thereof, in the presence of a tertiary phosphine, characterized by the use of a rhodium salt catalysts, wherein the rhodium is bonded to a polysiloxane carrier, having the following formulae:Rh Cl.sub.3 [N{(CH.sub.2).sub.3 SiO.sub.3/2 }.sub.3 ].sub.10Rh Cl.sub.3 [N{(CH.sub.2).sub.3 SiO.sub.3/2 }.sub.3 ].sub.12Rh Cl.sub.3 [N{(CH.sub.2).sub.3 SiO.sub.3/2 }.sub.3 ].sub.15Rh Cl.sub.3 [HN{(CH.sub.2).sub.3 SiO.sub.3/2 }.sub.2 ].sub.4Rh Cl.sub.3 [HN{(CH.sub.2).sub.3 SiO.sub.3/2 }.sub.2 ].sub.8permitting easy recovery of the rhodium, by simple filtration. | ||||||
| 138 | Process for the preparation of .alpha.-6-deoxytetracyclines | US509055 | 1974-09-25 | US3962331A | 1976-06-08 | Gino Cotti |
| This invention relates to a process for the preparation of .alpha.-6-deoxytetracyclines, by the simultaneous reductive dehalogenation and reduction by hydrogen, in a polar solvent of the corresponding 11a-halo-6-demethyl-6-deoxy-6-methylene-tetracycline, in presence of a suitable member of the group of the tertiary phosphines, arsines and stibines, as regards the dehalogenation and of a catalyst, selected from amongst the complexes of noble metals with electron-donor ligands, soluble in the reaction medium, whereby the reaction is carried out according to the mechanism of the homogeneous catalysis. | ||||||
| 139 | Process for producing oxytetra-cycline antibiotic | US43533665 | 1965-02-25 | US3408258A | 1968-10-29 | ARPAD GREIN; RICCARDO BARCHIELLI |
| 140 | Fermentative production of nu-ethyloxytetracycline | US44222365 | 1965-01-21 | US3390055A | 1968-06-25 | DULANEY EUGENE L; IRVING PUTTER |
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