| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 101 | 카복시알킬 디펩타이드의 제조방법 | KR1019840002507 | 1983-06-04 | KR1019840009032A | 1984-12-24 | 홍솅탄; 베르나르두스레오나르두스요하네스디이크그라이프; 로베르트뷰커스 |
| 내용없음 | ||||||
| 102 | 新穎9–胺基–7–取代–6–去甲基–6–去氧四環素 | TW081106574 | 1992-08-19 | TW222616B | 1994-04-21 | 文.傑.李; 宋懷英; 約克.格路曼; 約瑟夫.傑.拉威卡 |
| 揭示具有活性的新穎９－胺基－７－取代－６－去甲基－６－去氧四環素以對抗含有會抵抗四環素的有機體之寬譜有機體。也揭示為製備本發明新穎化合物的中間物及方法。 | ||||||
| 103 | 6–脫甲基–6–脫氧–6–甲︴–四環素之製造法 | TW06312025 | 1974-07-18 | TW025656B | 1979-07-01 | 吉諾哥帝 |
| 104 | Manufacture of alpha-6-deoxy-tetracyclines | JP17051684 | 1984-08-17 | JPS60126255A | 1985-07-05 | FUIRITSUPU RONARUDO PEEJI |
| 105 | 新穎7–取代–9–取代–胺基–6–去甲基–6–去氧四環素 | TW081106768 | 1992-08-27 | TW275616B | 1996-05-11 | 艾德馬.艾.羅斯; 宋泰英; 威.傑.李; 約瑟夫.傑.拉凱; 耶柯夫.格路茲曼 |
| 本發明是揭示可拮抗對四環素具性有機體在內之大範圍有機體之新穎的7-經取代-9-(經取代之胺基)-6-去甲基-6-去氧四環素化合物。也揭示製備本發明新穎化合物之中間物及方法。 | ||||||
| 106 | METHOD OF USING TETRACYCLINE COMPOUNDS FOR INHIBITION OF NITRIC OXIDE PRODUCTION | PCT/US9714723 | 1997-08-21 | WO9808480A2 | 1998-03-05 | AMIN ASHOK R; ABRAMSON STEVEN B; GOLUB LORNE M; RAMAMURTHY NUNGAVARAM S; MCNAMARA THOMAS F; GREENWALD ROBERT A; TRACHTMAN HOWARD |
| The invention is a method of inhibiting the production of nitric oxide (NO) in an in vivo, in vitro, or ex vivo biological system. The method employs a tetracycline compound to inhibit the production of NO and/or to inhibit the expression or activity of an inducible isoform ot nitric oxide synthase (iNOS). Preferably, the tetraclycine compound has inhibitory activity for metalloproteinases. Also it is preferred that the tetracycline compound is provided to the biological system in an amount which has little or no antibacterial activity in the system. Accordingly, preferred tetraclycine compounds are tetracycline compounds which have been modified to reduce or eliminate their antimicrobial activity. The method can be used to treat medical conditions in mammals characterized by NO production mediated by iNOS, including, for example, inflammatory conditions. | ||||||
| 107 | Nu-ethyloxytetracycline | US42821765 | 1965-01-26 | US3394178A | 1968-07-23 | DULANEY EUGENE L; IRVING PUTTER |
| 108 | 12alpha-deoxyanhydrotetracyclines | US69301857 | 1957-10-29 | US2922817A | 1960-01-26 | ARTHUR GREEN |
| 109 | 製造9–胺基–6–去甲基–6–去氧四環素之新方法 | TW081108728 | 1992-11-03 | TW221412B | 1994-03-01 | 非恩.桑 |
| 本發明係關於製造〔4S－(4α，12aα)〕－９－胺基－４－（二甲胺基）－１，４－4a，５，5a，６，11，12a－八氫－３，10，12，12a－四羥基－１，11－二氧基－２－羧醯胺的新穎方法，本文後稱為９－胺基－６－去甲基－６－去氧四－環素，該化合物是四環素合成的重要中間物。 | ||||||
| 110 | EPOXY RESIN SYSTEM CONTAINING POLYETHYLENE TETRAAMINES FOR RESIN TRANSFER MOLDING PROCESSES | PCT/US2013/069378 | 2013-11-11 | WO2014078219A1 | 2014-05-22 | GRUNDER, Sergio; KOENIGER, Rainer; MORLEY, Timothy A.; JELIC, Nebjosa; REIMERS, Martin; CATE, Peter |
A two-component curable epoxy resin system is disclosed. The resin system includes an epoxy resin component containing at least 80% by weight of a polyglycidyl ether of a polyphenol. The system also includes a hardener mixture containing mainly polyethylene tetraamines. The system includes one or more of i) alkali metal salts, ii) carboxylic acid-, carboxylic anhydride- or carboxylic acid ester-substituted phenol compounds, iii) an amino as a catalyst. The system has beneficial curing characteristics that make it useful for producing fiber-reinforced composites in a resin transfer molding process. |
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| 111 | 过氧化物还原酶IV在制备类风湿关节炎体外诊断试剂中的应用 | PCT/CN2011/083637 | 2011-12-07 | WO2012100599A1 | 2012-08-02 | 吴乔; 吴玉章 |
| 112 | α-6-데옥씨-5-하이드록씨 테트라 싸이클린과 소듐 테트라메타포스 페이트의 수용성 복합체의 제조방법 | KR1019810004468 | 1981-11-19 | KR1019830007076A | 1983-10-14 | 이반빌락스 |
| 내용없음 | ||||||
| 113 | α-6-데옥시-5-하이드록시 테트라사이클린염산염의 제조방법 | KR1019750001108 | 1975-05-20 | KR100008929B1 | 1980-11-27 | 챠아르즈죤빈센트스캐니오 |
| 114 | 6-데 메틸-6- 데옥시-6- 메티렌- 테트라싸이크린의 제조 방법 | KR1019740003787 | 1974-10-11 | KR1019790000520B1 | 1979-05-31 | 지노코티 |
| Title compds. [II; R = H, OH, -o-COR1 (R1 = C1-6 alkyl), Y = H or halogen , useful as antibiotics, were prepd. by dehydrohalogenation of lla-halo-6-demethyl-6-deoxy-6 -methylenetetracycline (I ; X = halogen) or its salts. Thus, I was dehydrohalogenated by PPh3, arsine or stibine in a solvent such as mono- or polyhydroxyalc., methoxyEtoH, ethoxyEtoH having 1-4 carbon atoms and dioxane, tetrahydrofuran, acetonitryl, DMF or acetone at 20-80≦̸C for 30-60 min to give I. | ||||||
| 115 | 9-아미노-6-데메틸-6-데옥시테트라시클린 무기산염의 제조 방법 | KR1019930015642 | 1993-08-12 | KR100280971B1 | 2001-02-01 | 파이크-엥슘 |
| 본 발명은 테트라시클린의 합성을 위해 가치있는 중간체인, 이후에 9-아미노-6-데메틸-6-데옥시테트라시클린으로 불리는 [4S-(-알파, 12a알파)]-9-아미노-4-(디메틸아미노)-1,4,4a,5,5a,6,11,12a-옥타히드로-3,10,12,12a-테트라히드록시-1,11-디옥소-2-나프타센카르복사미드의 새로운 제조방법에 관한 것이다. | ||||||
| 116 | 6-데 옥시- 테트라싸이크린의 수용성 유도체의 제조 방법 | KR1019740003789 | 1974-10-11 | KR100008206B1 | 1980-06-02 | 지노코티 |
| 117 | A process for the preparation of 1-alkyl-3-carboxy-4-cinnolones. | EP88105021.5 | 1988-03-28 | EP0287853A3 | 1990-07-18 | Fusco, Raffaello; Piselli, Fulvio L.; Boschi, Pier Marino |
A process for the preparation of 1-alkyl-3-carboxy-4-cinnolones of formula I
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| 118 | 6–脫甲基–6–脫氧–6–甲︴–5一氧代四環素及其lla一氯衍生物之製法 | TW073104176 | 1984-10-08 | TW066080B | 1985-04-01 | |
| 119 | 9[(經取代胺乙醯基)醯胺基]–6–去甲基–6–去氧四環素 | TW081108727 | 1992-11-03 | TW269678B | 1996-02-01 | 非恩.桑; 敏.J.李; 羅蒙.T.提斯塔 |
| 本發明提供下式之化合物：CC其中Ｒ ，Ｒ1及Ｗ 定義於專利說明書中。此合物可充作抗生素。 | ||||||
| 120 | PROCESS FOR THE PRODUCTION OF ALPHA-6-DEOXYTETRACYCLINES | EP90902446.0 | 1990-01-02 | EP0452412A1 | 1991-10-23 | KRSEK, George |
| L'invention concerne un procédé de préparation d'alpha-6-désoxytétracyclines à partir des 6-méthylènetétracyclines correspondantes, utilisant un catalyseur de rhodium hétérogène à support de silice de formule générale (I), dans laquelle R et R' sont chacun choisis entre l'hydrogène et l'alcoyle contenant 1 à 4 atomes de carbone, x est un nombre entier compris entre 1 et 6, Ph représente phényle, y représente un nombre entier compris entre 1 et 3, et L représente un ligand choisi parmis des phosphines d'aloyldiphényle à substitution alcoxysilyle. Ledit procédé produit stéréospécifiquement les épimères alpha à des rendements supérieurs tout en utilisant des niveaux de rhodium inférieurs à ceux des procédés antérieurs. | ||||||
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