SUBSTITUTED BENZALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION |
|||||||
申请号 | EP12862525 | 申请日 | 2012-12-28 | 公开(公告)号 | EP2797416A4 | 公开(公告)日 | 2015-12-23 |
申请人 | GLOBAL BLOOD THERAPEUTICS INC; CYTOKINETICS INC; UNIV CALIFORNIA; | 发明人 | METCALF BRIAN; CHUANG CHIHYUAN; WARRINGTON JEFFREY; PAULVANNAN KUMAR; JACOBSON MATTHEW P; HUA LAN; MORGAN BRADLEY; | ||||
摘要 | Provided are substituted benzaldehydes and derivatives thereof of formula (I) that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation. | ||||||
权利要求 | |||||||
说明书全文 |