Epitope focusing by variable effective antigen surface concentration |
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| 申请号 | US14398084 | 申请日 | 2013-05-21 | 公开(公告)号 | US09884893B2 | 公开(公告)日 | 2018-02-06 |
| 申请人 | DISTRIBUTED BIO, INC.; | 发明人 | Jacob E. Glanville; | ||||
| 摘要 | The present disclosure provides compositions and methods for the generation of an antibody or immunogenic composition, such as a vaccine, through epitope focusing by variable effective antigen surface concentration. Generally, the composition and methods of the disclosure comprise three steps: a “design process” comprising one or more in silico bioinformatics steps to select and generate a library of potential antigens for use in the immunogenic composition; a “formulation process”, comprising in vitro testing of potential antigens, using various biochemical assays, and further combining two or more antigens to generate one or more immunogenic compositions; and an “administering” step, whereby the immunogenic composition is administered to a host animal, immune cell, subject or patient. Further steps may also be included, such as the isolation and production of antibodies raised by host immune response to the immunogenic composition. | ||||||
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| 说明书全文 | |||||||
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