특이적 병원균에 대한 항원을 동정하고 분리하여 생산하는 방법

특이적 병원균에 대한 항원을 동정하고 분리하여 생산하는 방법{A METHOD FOR IDENTIFICATION, ISOLATION AND PRODUCTION OF ANTIGENS TO A SPECIFIC PATHOGEN}

본원 발명은 특이적 병원균에 대한 항원을 동정하고 분리하여 생산하는 방법 및 일정한 동물이나 인체에서 백신으로 사용하는데 적합한 신규한 항원에 관한다.

백신은 어떤 다른 의학적 개입보다 더 많은 생명(및 자원)을 구할 수 있다. 세계적인 백신 프로그램으로 인하여 많은 치명적 질환의 발병률이 현저하게 감소하였다. 이런 견해는 광범위한 질환, 예를 들면, 디프테리아, 백일해, 홍역, 파상풍에도 적용되지만, HIV, HCV, CMV 등과 같은 대부분의 바이러스 감염을 비롯한 다수의 감염성 질환에 대한 효과적인 백신은 존재하지 않는다. 말라리아 또는 암을 비롯한 연간 수백만명의 생명을 앗아가는 다른 감염성 또는 비-감염성 질환에 대한 효과적인 백신 역시 존재하지 않고 있다. 이에 더하여, 항생제-저항성 박테리아와 미생물의 급격한 출현은 백신이 논리적으로 선택되는 대안적 치료법을 요구하고 있다. 최종적으로, 백신에 대한 필요성은 심혈관 질환, 암 또는 외상보다는 감염성 질환이 여전히 전세계적으로 사망과 장애의 최대 원인이라는 사실에 의해서도 뒷받침된다.

몇몇 기존 백신은 살아있는 약독화된 미생물로 구성되는데, 이런 경우에 유독성의 야생형 균주로 반전될 위험이 존재한다. 특히, 면역약화된 숙주에서 이는 생명을 위협할 수도 있다. 대안으로, 백신은 병원균-유래된 항원 및 이들 항원에 대한 면역 반응을 유도 또는 강화하는 화합물(이들 화합물은 일반적으로 어쥬번트라고 한다)과의 조합으로 투여되는데, 그 이유는 이들 아단위 백신이 단독으로는 효과적이지 못하기 때문이다.

의심할 여지없이 상기 백신들이 귀중한 치료 방법이긴 하지만, 이들의 복합성으로 인하여, 예방접종된 개체의 세포에 의해 발현되는 분자와 교차-반응성을 보이는 백신에 포함되는 항원에 대한 부작용이 초래될 수 있다. 이에 더하여, 백신 조성물의 정확한 규격 및 면역 도입 기전에 대한 통제 당국, 예를 들면, 세계 보건 기구(WHO), 식품의약국(FDA), 이들에 대응하는 유럽 기구의 요구사항은 충족하기 쉽지 않다.

광범위하게 사용되는 백신은 전체 세포-백신, 예를 들면, 약독화된 박테리아나 바이러스(예, Bacille Calmette-Guerin(BCG)(결핵), 홍역, 이하선염, 풍진, 경구 폴리오 백신(Sabin)), 사멸된 박테리아나 바이러스(예, 백일해, 불활화된 폴리오 백신(Salk)), 아단위-백신(예, 변성 독소(디프테리아, 파상풍)), 협막 폴리사카라이드(H. 인플루엔자 B형), 효모 재조합 아단위(B형 간염 표면 단백질)이다.

백신은 전혀 상이한 항원을 함유할 수 있다. 항원의 예는 완전히 죽은 생물, 예를 들면, 불활화된 바이러스나 박테리아, 곰팡이, 원생동물 또는 암세포이다. 항원은 이들 생물/조직 또는 단백질(또는 가장 단순한 형태의 단백질) 소분획물(subfraction)로 구성될 수도 있다. 항원은 당화된 단백질 또는 펩티드 형태로 면역계에 의해 인식될 수 있고 폴리사카라이드 또는 지질 자체이거나 이들을 보유할 수도 있다. 예로써, 세포독성 T 세포(CTL)가 주조직접합성 복합체(MHC)와 결합된 일반적으로 짧은 8-11 아미노산 길이의 펩티드를 인식한다는 점에서 짧은 펩티드를 사용할 수 있다. B 세포는 4-5개 아미노산의 짧은 선형 에피토프 및 3차원적 구조(입체형태적 에피토프)를 인식할 수 있다. 지속적인 항원-특이적 면역 반응을 얻기 위하여, 필요한 면역계의 모든 세포가 포함되는 면역 캐스케이드를 유인하는 데에는 어쥬번트가 효과적이다. 기본적으로, 어쥬번트는 항원 제시 세포(APC)에 작용한다. 이들 세포는 먼저 항원과 직면하고, 이후 가공된 또는 변형된 항원을 면역 주효체에 제시한다. 중간단계 세포형이 참여할 수도 있다. 적절한 특이성을 갖는 주효체 세포만이 생산적 면역 반응에서 활성화된다. 어쥬번트는 또한 항원과 동시-주입된 다른 인자를 국소적으로 보유할 수도 있다. 이에 더하여, 어쥬번트는 다른 면역세포에 대한 유인물질로 작용하거나 또는 면역계에 대한 촉진물질로서 국소적으로 및/또는 전신적으로 작용할 수 있다.

항원 제시 세포는 선천성 면역계(innate immune system)에 속하는데, 이는 미생물에 대한 노출직후에 감염을 제한하는 제 1 숙주 방어선으로 진화하였다. 선천성 면역계 세포는 적응성 면역계(adaptive immune system)에 의해 인식되는 더욱 정교하고 특이적인 구조보다는 오히려 표적에서 발현되는 패턴 또는 상대적으로 비-특이적인 구조를 인식한다. 선천성 면역계 세포의 예는 대식세포, 수상돌기 세포, 과립백혈구(예, 호중구), 고유 살해 세포 등이다. 대조적으로, 적응성 면역계 세포는 T 세포의 경우에 펩티드를 비롯한 특이적인 항원 구조 및 B 세포의 경우에 펩티드와 3차원 구조를 인식한다. 적응성 면역계는 선천성 면역계보다 훨씬 더 특이적이고 정교하며, 임의의 병원균/항원에 반복적으로 노출될 때에 증대된다. 계통발생학적으로, 선천성 면역계는 훨씬 오래되었고 매우 원시적인 생물에서도 발견할 수 있다. 그럼에도 불구하고, 선천성 면역계는 초기 단계의 항원 노출동안 중요한데, 그 이유는 병원균의 억제이외에 선천성 면역계 세포(즉, APC)가 적응성 면역계 세포를 기폭하고 침입자의 제거로 귀결되는 특이적인 면역 반응을 유인하기 때문이다. 요약하면, 선천성 면역계 세포 및 특히 APC는 a) 원시적인 패턴 인식 시스템으로 감염을 억제하고 b) 적응성 면역계 세포를 기폭하여 침입 병원균 또는 다른 표적의 소거를 결과하는 특이적 면역 반응과 기억을 유도함으로써 초기 단계 면역 반응 동안 중요한 역할을 수행한다(Roitt et al., 1998). 이들 기전은 종양 세포를 소거 또는 억제하는 데에도 중요하다.

이런 백신에 사용되는 항원은 무작위 또는 입수가능성의 용이함으로 종종 선택된다. 일정한 병원균에 효과적인 항원 또는 바람직하게는, 실질적으로(임상적으로) 적합한 병원균의 거의 모든 항원 세트를 확인하는 것이 요구된다. 이런 항원은 백신에 바람직한 항원 후보일 수 있다.

따라서, 본원 발명의 목적은 이들 요구를 충족시키고, 이런 항원을 제공하고 예로써, 일정한 병원균의 실질적으로 모든 항원 세트를 일정한 혈청을 항체원으로 하여 확인할 수 있는 방법을 제시하는 것이다. 이런 방법은 일반적인 약물이나 백신에 대한 저항성을 신속하게 발전시키는 급속하게 변하는 병원균에도 적합할 수 있다. 상기 방법은 종양 항원, 알레르겐, 또는 자가면역 항원을 확인하는데 이용될 수 있다.

따라서, 본원 발명은 특정 병원균, 종양, 알레르겐, 또는 자가 면역성을 가지기 쉬운 조직이나 숙주, 특히, 특정 병원균으로부터 과다면역 혈청-반응성 항원을 동정하고 분리하여 생산하는 방법을 제시하는데, 상기 항원은 특정한 동물이나 인간에서 백신으로 사용하는데 적합하고, 상기 방법은 다음의 단계로 특성화된다:

- 특정 병원균, 종양, 알레르겐, 또는 자가 면역성을 가지기 쉬운 조직이나 숙주에 대한 항체를 포함하는 동물 혈장액, 또는 인간 혈장액 또는 개별 혈청으로부터 항체 조제물을 제공하는 단계;

- 특정 병원균, 종양, 알레르겐, 또는 자가 면역성을 가지기 쉬운 조직이나 숙주의 최소한 1가지 발현 라이브러리를 제공하는 단계;

- 항체 조제물을 이용하여 최소한 1가지 발현 라이브러리를 선별하는 단계;

- 선별 과정에서 항체 조제물 내에 항체에 결합하는 항원을 확인하는 단계;

- 확인된 항원을 특정 병원균, 종양, 알레르겐, 또는 자가 면역성을 가지기 쉬운 조직이나 숙주에 대한 항체를 포함하는 개체의 개별 혈청으로부터 유래된 개별 항체 조제물로 선별하는 단계;

- 확인된 항원의 과다면역 혈청-반응성 항원 부분을 확인하고, 이때 과다면역 혈청-반응성 항원은 개별 혈청으로부터 유래된 개별 항체 조제물의 관련 부분에 결합하는 단계;

- 과다면역 혈청-반응성 항원을 선택적으로 분리하고, 화학적 또는 재조합 방법을 이용하여 과다면역 혈청-반응성 항원을 생산하는 단계.

상기 방법은 최소한 3가지의 상이한 발현 라이브러리가 본원 발명에 따른 방법을 이용한 병원균/항원 동정 프로그램으로 선별되면, 일정한 혈청을 항체원으로 하여 실질적으로 완전한 세트의 과다면역 혈청-반응성 항원을 확인하는 데에도 적합하다. 따라서, 본원 발명은 특정 병원균의 실질적으로 완전한 세트의 과다면역 혈청-반응성 항원을 동정하고 분리하여 생산하는 방법에 관하는데, 상기 항원은 특정한 동물이나 인간에서 백신으로 사용하기에 적합하고, 상기 방법은 다음의 단계로 특성화된다:

- 특정 병원균에 대한 항체를 포함하는 동물 혈장액, 또는 인간 혈장액 또는 개별 혈청으로부터 항체 조제물을 제공하는 단계;

- 특정 병원균의 최소한 3가지 상이한 발현 라이브러리를 제공하는 단계;

- 항체 조제물을 이용하여 최소한 3가지 상이한 발현 라이브러리를 선별하는 단계;

- 최소한 3가지 선별 과정 중에서 적어도 하나에서, 항체 조제물 내에 항체에 결합하는 항원을 확인하는 단계;

- 확인된 항원을 특정 병원균에 대한 항체를 포함하는 개체로부터 개별 혈청으로부터 유래된 개별 항체 조제물로 선별하는 단계;

- 확인된 항원의 과다면역 혈청-반응성 항원 부분을 확인하고, 이때 과다면역 혈청-반응성 항원은 개별 혈청으로부터 유래된 개별 항체 조제물의 관련 부분에 결합하는 단계;

- 최소한 한번은 선별과 확인 단계를 반복하는 단계;

- 반복된 선별과 확인 단계에서 확인된 과다면역 혈청 반응성 항원과 최초 선별과 확인 단계에서 확인된 과다면역 혈청-반응성 항원을 비교하는 단계;

- 반복된 선별과 확인 단계에서 최소한 5%의 과다면역 혈청-반응성 항원이 확인되면, 추가의 반복 단계에서 5% 미만의 과다면역 혈청-반응성 항원이 확인될 때까지 선별과 확인 단계를 더욱 반복하여 특정 병원균의 과다면역 혈청-반응성 항원의 완전한 세트를 수득하는 단계;

- 과다면역 혈청-반응성 항원을 선택적으로 분리하고, 화학적 또는 재조합 방법을 이용하여 과다면역 혈청-반응성 항원을 생산하는 단계.

본원 발명에 따른 방법은 3가지 필수 단계, 다시 말하면, 1. 일정한 병원균에 특이적인 항원을 포함하는 과다면역 혈청원의 확인; 2. 후보 항원(또는 이런 항원의 항원성 단편)이 선별되는 적절한 항체 조제물로 적합한 발현 라이브러리의 선별; 3. 개인 항체로부터 유래된 개별 항체 조제물 일부에 결합하는 능력으로 과다면역 혈청-반응성 항원을 확인하는 2차 선별, 여기서 이들 항원은 실질적으로 유관하고 과다면역 혈청-반응성뿐만 아니라 광범위한 면역원성(즉, 다수의 개별 항체가 항원과 반응한다)을 나타낸다. 본원 발명의 방법으로, 선택된 병원 및 선택된 혈청과 실질적으로 경쟁하는 병원균의 일단의 항원을 제시하는 것이 가능하다. 따라서, 본원 발명에서는 병원균의 “잘못된” 항원 후보 또는 불완전한 일단의 항원과 관련된 선입견이 배제된다.

본원 발명에서 병원균의 항원 세트의 완전성은 라이브러리의 대표성 및 발현 시스템의 유용성과 관련하여, 본원 발명에 이용되는 발현 라이브러리의 완전성 및 검사된 혈청 수집물(다수의 개별 혈장/혈청)의 품질과 크기에 좌우된다. 따라서, 본원 방법의 적절한 구체예에서 상기 발현 라이브러리중 적어도 한 가지는 리보솜 전시 라이브러리, 박테리아 표면 라이브러리, 프로테옴에서 선택된다.

본원 발명에 사용되는 혈청 수집물은 일정한 병원균의 공지된 항원성 화합물 패널, 예를 들면, 세포벽, 세포막, 세포질의 폴리사카라이드, 지질, 단백질성 구성요소 및 분비된 산물에 대하여 검사한다. 적절하게는, 3가지의 상이한 혈청 수집물이 이용된다: 1. 매우 안정한 항체 레퍼토리: 급성 질환이나 증상 없이 일정한 병원균의 사전 조우 또는 현재의 보균을 극복하는 정상적인 성인, 임상적으로 건강한 사람; 2. 병원성 미생물의 존재에 의해 실제로 유도된 항체: 상이한 증상의 급성 질환을 보이는 환자; 3. 특이적인 항체 없음(네거티브 대조): 출생 5-6개월후 모체로부터 전달된 면역글로불린을 상실한 5-8개월된 아기. 혈청은 일정한 병원균(박테리아, 진균, 기생충 등) 및 본원 발명에 다른 선별 방법에 적합한 병원균에 대한 과다면역을 고려하기 위하여 다중의 병원균-특이적 항원과 반응해야 한다.

본원 발명에 따른 완전한 항원 세트를 확인하기 위한 항원 동정 프로그램에서, 적어도 3가지의 상이한 발현 라이브러리는 적어도 한가지의 리보솜 전시 라이브러리, 박테리아 표면 라이브러리, 프로테옴이어야 한다. 모든 발현 라이브러리가 완전할 수 있지만, 상이한 발현 라이브러리 각각의 선택적 발현 특성으로 인하여 항원 동정 프로그램에서 한두 개의 발현 라이브러리가 완전한 항원 세트를 결과할 수는 없다. 따라서, 한두 개의 상이한 발현 라이브러리로 과다면역 혈청-반응성항원을 수득하는 것이 가능하긴 하지만, 이는 많은 경우에 완전한 세트의 과다면역 혈청-반응성 항원의 동정을 결과하지 못한다. 본원 발명에서 “완전한”은 이론적 최대치가 아닌 실질적인 완전성, 다시 말하면, 병원균의 실질적으로 적절한 항원이나 항원 결정기중 적어도 95%가 확인된다는 것을 의미한다. 따라서, 실질적인 적절성(relevance)은 환자 개체군에서 일정한 병원균에 대한 항체의 발생으로 정의된다.

본원 발명에서, 혈청액이나 혈청 분취물 또는 체액을 함유하는 다른 공동 항체는“혈장액”이라 한다.

본원 발명에 사용되는 발현 라이브러리는 모든 잠재적 항원, 예를 들면, 일정한 병원균의 모든 표면 단백질의 발현을 적어도 가능하게 한다. 본원 발명에 따른 발현 라이브러리로 일정한 병원균의 적어도 한가지 세트의 잠재적 항원을 제시하는데, 상기 세트는 바람직하게는, 병원균 게놈(즉, 실시예 2에서 밝힌 게놈 라이브러리)에 의해 인코드되는 (폴리-)펩티드의 완전한 이론적 보체이고 재조합 숙주(실시예 3) 또는 시험관내(실시예 4)에서 발현된다. 세포외 병원균의 경우에 이런 잠재적 항원 세트는 단백질 조제물, 바람직하게는, 규정된 생리 조건하에서 배양된 병원균으로부터 얻은 상기 병원균의 표면 단백질을 함유하는 단백질 조제물일 수도 있다(실시예 5). 게놈 접근방식이 완전한 세트의 항원을 포함하는 잠재력을 갖고 있긴 하지만, 후자 방식은 자연 상태에서 이들 단백질을 포함하는, 다시 말하면, 예로써, DNA 서열로부터 자명하지 않은 이들 단백질의 번역후 수식 또는 가공된 형태를 포함하는 이점이 있다. 병원균, 종양, 알레르겐, 또는 자가 면역성을 가지기 쉬운 조직이나 숙주로부터 유래된 이들이나 임의의 다른 세트의 잠재적 항원은 이후 “발현 라이브러리”라고 한다. 다양한 종류의 발현 라이브러리가 본원 발명의 과정에 이용될 수 있다. 바람직한 실례는 Ausubel et al., 1994에 제시한다. 특히 바람직하게는, 재조합 형태로 병원균의 유전자 세트의 전시를 대표하는 발현 라이브러리, 예를 들면, 시험관내 번역 기술(예, 리보솜 전시), 원핵 발현 시스템(예, 박테리아 표면 라이브러리) 또는 일정한 생리 상태에서 일정한 병원균의 특이적인 생리 발현 상태를 모방하는 라이브러리이다.

리보솜 전시는 재조합 DNA 기술에서 확립된 방법인데, 상기 방법은 본원 발명의 각 특정 병원균에 적용가능하다(Schaffitzed et al, 1999). 박테리아 표면 전시 라이브러리는 일정한 병원균의 일단(전체)의 발현된 펩티드 서열, 예를 들면, 박테리아 숙주 막에서 선택된 외부막 단백질을 전시하는 박테리아 숙주의 재조합 라이브러리에 의해 대표된다(Georgiou et al., 1997). 외부막 단백질에서 펩티드 또는 단백질 서열의 전시이외에, 다른 박테리아 전시 기술, 예를 들면, 박테리오파아지 전시 기술 및 외부로 전달된 단백질을 통한 발현 역시 박테리아 표면 발현 라이브러리로 바람직하다(Forrer et al., 1999; Rodi and Makowski, 1993; Georgiou et al., 1997).

본원 발명에 따른 방법에서 1차 선별을 위한 항원 조제물은 일정한 병원균에 대한 항체를 보유하는 임의의 출처로부터 유래될 수 있다. 적절하게는, 혈장액이 항체 조제물의 출처로 사용되면 주어지 병원균으로 감염을 경험했거나 또는 경험하고 있는 공여물질을 포함하는 인간 혈장액이 선별된다. 혈장이나 혈장액의 이런 선별이 예로써, 과다면역글로불린 조제물질의 생산에서 원칙적인 표준 기술이긴 하지만, 놀랍게도 이런 기술은 본원 발명의 적절한 구체예에 도시된 효과를 보인다.

적절하게는, 발현 라이브러리는 일정한 병원균의 게놈 발현 라이브러리, 또는 대안으로 mRNA 라이브러리이다. 이들 게놈이나 mRNA 라이브러리는 바람직하게는, 완전한 게놈이나 mRNA 발현 라이브러리인데, 이런 사실은 이들이 일정한 병원균의 적어도 한가지의 모든 가능한 발현가능 단백질, 펩티드 또는 펩티드 단편을 포함한다는 것을 의미한다. 게놈 발현 라이브러리는 바람직하게는, 적어도 2x, 더욱 바람직하게는, 적어도 5x, 가장 바람직하게는, 적어도 10x의 과잉을 보인다.

적절하게는, 본원 발명에 따른 방법은 항체 조제물로 적어도 한가지 리보솜 전시 라이브러리, 박테리아 표면 전시 라이브러리, 프로테옴을 선별하고, 적어도 2개, 바람직하게는, 전체 선별에서 상기 항체 조제물에서 항체에 결합하는 항원을 확인하는 단계로 구성된다. 이후, 이런 항체는 발현의 방식에 상관없이 과다면역 항원으로 매우 적합한 것으로 간주될 수 있다. 적절하게는, 적어도 2개의 선별은 프로테옴을 적어도 포함하여야 하는데, 그 이유는 프로테옴이 DNA 서열로부터 자명하지 않은 번역후 수식, 가공 등을 포함하는 자연적으로 발현된 단백질로서 항원을 항상 대표하기 때문이다.

본원 발명에 따른 방법은 임의의 일정한 병원균에 적용될 수 있다. 따라서, 바람직한 병원균은 박테리아, 바이러스, 진균, 원생동물 병원균에서 선택된다. 본원 발명에 따른 방법은 암, 다시 말하면, 종양-관련된 항원의 동정 및 자가-면역 질환에 관여하는 알레르겐이나 항원의 동정에도 적용가능하다. 특히, 재조합 방법은 작은 게놈이나 상대적으로 적은 수의 발현된 단백질을 갖는 병원균(예, 박테리아 또는 바이러스 병원균)에서는 상당히 간단하고 대량의 게놈을 갖는 복잡한(진핵) 생물에서는 더욱 복잡하다. 하지만, 고등 생물 병원균의 이런 대규모 게놈 라이브러리는 본원 발명에 따라 적합한 항원을 확인하는 공지된 방법에서보다 더욱 신속하고 신뢰할 수 있는 방식으로 분석될 수 있다.

분석하거나 또는 항원이 추출되는 바람직한 병원균에는 인간 면역결핍 바이러스(HIV), A형 간염 바이러스(HAV), B형 간염 바이러스(HBV), C형 간염 바이러스(HCV), 라우스 육종 바이러스(RSV), 엡스테인 바르 바이러스(EBV), 인플루엔자 바이러스(IV), 로타바이러스(RV), 스타필로코커스 아우레우스( Staphylococcus aureus ), 스타필로코커스 에피데르미디스( Staphylococcus epidermidis ), 클라미디아 뉴모니아( Chlamydia pneumoniae ), 클라미디아 트라코마티스( Chlamydia trachomatis ), 미코박테리움 튜베르쿨로시스( Mycobacterium tuberculosis ), 미코박테리움 레프라( Mycobacterium leprae ), 스트렙토코커스 뉴모니아( Streptococcus pneumoniae ), 스트렙토코커스 피오젠( Streptococcus pyogenes ), 스트렙토코커스 아갈락티아( Streptococcus agalactiae ), 엔테로코커스 페칼리스( Enterococcus faecalis ), 바실러스 안트라시스( Bacillus anthracis ), 비브리오 콜레라( Vibrio cholerae ), 보렐리아 부르그도르페리( Borrelia burgdorferi ), 말라리아 종( Plasmodium sp . ), 진균 질환(예, 뉴모시스티스 카리니(Pneumocystis carinii)), 아스페르길루스 종( Aspergillus sp . ), 크립토코커스 종( Cryptococcus sp . ), 칸디다 알비칸스( Candida albicans ), 또는 기생충 감염(예, 회충증(Ascaris lumbricoides)과 조충증(Taenia saginata))이 포함된다. 본원 발명에 따른 방법은 박테리아, 기생충 또는 칸디다균에 가장 적합하다.

본원 출원의 모델 미생물로서 스타필로코커스 아우레우스( Staphylococcus aureus)는 본원 발명에 따른 방법의 응용성 및 효율을 입증하기 위하여 선택되었다. 특히 실시예와 관련하여 본원 발명이 모든 잠재적 병원균, 특히 전술한 병원균에 쉽게 적용될 수 있음은 분명하다.

놀랍게도, 본원 발명에 따른 방법은 병원균이 효율적으로 퇴치될 수 있는 상황에서도 환자 항체 레퍼토리의 극히 일부만 일정한 병원균을 지향한다는 사실에 비추어, 일정한 병원균의 효율적이고 신속한 선별을 가능하게 한다. 본원 발명의 과정에서, 특히 스타필로코커스 아우레우스( S. aureus )의 실행동안 스타필로코커스 아우레우스( S. aureus )에 높은 역가를 갖는 환자의 항체 레퍼토리 중에서 단지 1-2%만 실제로 스타필로코커스 아우레우스( S. aureus )에 대한 항체인 것으로 확인되었다. 게다가, 이런 특이적 1% 부분의 70% 이상은 비-단백질 항원, 예를 들면, 테이코산(teichoic acid)을 지향하기 때문에, 항체 중에서 단지 0.1% 이하만이 단백질성 항원을 지향한다.

재조합 발현 라이브러리, 특히 리보솜 전시 라이브러리와 박테리아 표면 전시 라이브러리를 이용하는 이점중의 하나는 확인된 과다면역 혈청-반응성 항원이 추가적인 재조합 DNA 기술 또는 클로닝 단계없이 과다면역 혈청-반응성 항원을 발현하는 선별되고 선택된 클론의 코딩 서열의 발현으로 즉시 생성될 수 있다는 점이다.

따라서, 본원 발명에 따른 방법으로 수득되는 과다면역 혈청-반응성 항원은 예로써, 발현 라이브러리 플랫폼으로부터 발현으로, 생산 직후(2차 선별 단계 과정동안) 제약학적으로 수용가능한 담체 및/또는 부형제를 첨가하여 제약학적 조성물로 마감될 수 있다.

적절하게는, 과다면역 혈청-반응성 항원을 함유하는 제약학적 조성물은 항원이 선별된 특정 병원균의 감염을 예방 또는 치료하는 백신이다.

이런 제약학적 조성물은 적절한 보조 물질, 예를 들면, 완충물질, 안정제 또는 다른 활성 성분, 특히 백신 생산에 공지된 성분을 함유할 수 있다.

본원 발명에 따른 과다면역 혈청-반응성 항원에 적합한 담체 및/또는 부형제는 일정한 과다면역 혈청-반응성 항원에 대한 면역 반응을 더욱 촉진하는 면역촉진 화합물이다. 적절하게는, 본원 발명에 따른 제약학적 조성물에서 면역조절 화합물은 다가양이온 물질, 특히 다가양이온성 펩티드, 면역촉진 데옥시뉴클레오티드, 알루멘, 프레운드 완전 어쥬번트, 프레운드 불완전 어쥬번트, 신경활성 화합물, 특히 인간 성장 호르몬, 또는 이들의 혼합물에서 선택된다.

본원 발명에 사용되는 다가양이온성 화합물은 WO 97/30721에 따른 특징적인 효과를 보이는 임의의 다가양이온성 화합물일 수 있다. 바람직한 다가양이온성 화합물은 염기성 폴리펩티드, 유기 다가양이온, 염기성 폴리아미노산 또는 이들의 혼합물에서 선택된다. 이들 폴리아미노산은 적어도 4개 아미노산 잔기의 사슬 길이를 갖는다(Goldman et al., (1983)에서 Tuftsin). 특히 폴리리신, 폴리아르기닌 및 8개 이상, 적절하게는, 20개 이상의 아미노산 잔기 범위에서 20% 이상, 적절하게는, 50% 이상의 염기성 아미노산을 보유하는 폴리펩티드 또는 이들의 혼합물과 같은 물질이 바람직하다. 다른 바람직한 다가양이온과 이들의 제약학적 조성물은 WO97/30721(예, 폴리에틸렌이민) 및 WO99/38528에 기술되어 있다. 적절하게는, 이들 조성물은 20 내지 500개 아미노산 잔기, 바람직하게는, 30 내지 200개 잔기를 보유한다.

이들 다가양이온성 화합물은 화학적으로 혹은 재조합으로 생산되거나, 또는 천연 공급원으로 유도될 수 있다.

양이온성(폴리) 펩티드는 또한 Ganz and Lehrer, 1999에서 검증된 특성을 갖는 항균 펩티드일 수도 있다. 이들 (폴리)펩티드는 원핵생물, 동물 또는 식물로부터 기원하거나, 또는 화학적으로 혹은 재조합으로 생산될 수 있다(Andreu and Rivas, 1998; Ganz and Lehrer, 1990; Simmaco et al., 1998). 펩티드는 디펜신(defensin) 군에 속할 수도 있다(Ganz, 1999; Ganz and Lehrer, 1999). 이런 펩티드의 서열은 예로써, 다음과 같은 인터넷 주소하의 항균 서열 데이터에서 찾을 수 있다: http://www.bbcm.univ.trieste.it/~tossi/pag1.html.

이런 숙주 방어 펩티드 또는 방어물질 역시 본원 발명에 따른 다가양이온 중합체의 적합한 형태이다. 일반적으로, 최종 산물로서 APC(수상돌기 세포 포함)에 의해 매개되는 적응성 면역계의 최종 산물 활성화(또는 하향-조절)를 가능하게 하는 화합물이 다가양이온성 중합체로 사용된다.

카텔리시딘 유도된 항균펩티드 또는 이들의 유도체(PCT/EP01/09529), 특히 포유동물 카텔리시딘, 적절하게는, 사람, 소 또는 생쥐로부터 유래된 항균 펩티드가 본원 발명에 따른 다가양이온 물질로 적합하다.

천연 공급원으로부터 유래된 다가양이온성 화합물에는 HIV-REV 또는 HIV-TAT [유도된 양이온성 펩티드, 안테나페디아(antennapedia) 펩티드, 키토산 또는 키틴의 다른 유도체] 또는 생화학적 혹은 재조합적 생산으로 이들 펩티드나 단백질로부터 유도된 다른 펩티드가 포함된다. 다른 바람직한 다가양이온성 화합물은 카텔린 또는 카텔린과 관련되거나 이로부터 유래된 물질이다. 가령, 생쥐 카텔린은 아미노산 서열 NH ₂ -RLAGLLRKGGEKIGEKLKKIGOKIKNFFQKLVPQPE-COOH을 보유하는 펩티드이다. 관련되거나 유래된 카텔린 물질은 적어도 15-20개 아미노산 잔기를 보유하는 카텔린 서열의 전체 또는 일부를 포함한다. 유도에는 고유 아미노산의 20개 표준 아미노산을 제외한 다른 아미노산의 치환 또는 변경이 포함될 수 있다. 게다가, 추가적인 양이온성 잔기가 이런 카텔린 분자에 도입될 수 있다. 적절하게는, 이들 카텔린 분자는 항원과 결합된다. 놀랍게도, 이들 카텔린 분자는 추가적인 어쥬번트의 첨가없이 항원에 대한 어쥬번트로서 효과적인 것으로 확인되었다. 따라서, 추가적인 면역활성 물질과 함께 또는 이런 면역활성 물질없이 백신 제형에 효과적인 어쥬번트로 이런 카텔린을 사용하는 것이 가능하다.

본원 발명에 사용되는 다른 적절한 다가양이온 물질은 3 내지 7개의 소수성 아미노산의 링커에 의해 분리되는 적어도 2개의 KLK-모티프를 보유하는 합성 펩티드이다(PCT/EP01/12041).

면역촉진 데옥시뉴클레오티드 자연이나 인공 CpG를 포함하는 DNA, 비-척추동물로부터 유래된 짧은 DNA 스트레치, 특정 염기 환경에 비-메틸화된 시토신-구아닌 이중-뉴클레오티드(CpG)를 포함하는 짧은 올리고뉴클레오티드(ODN)(Krieg et al., 1995) 또는 이노신을 포함하는 ODN(I-ODN)(WO 01/93905)이다.

예로써, 다가양이온성 물질과 결합된 신경활성 화합물은 WO 01/24822에서 기술한다.

적절한 구체예에 따라, 2차 선별을 위한 개별 항체 조제물은 일정한 병원균으로 급성 감염된 환자, 특히 일정한 병원균에 대한 특정 수준이상의 항체 역가, 예를 들면, 검사된 인체(환자 또는 보균자) 혈청의 80 백분위수 이상, 더욱 바람직하게는, 90 백분위수 이상, 가장 바람직하게는, 95 백분위수 이상의 항체 역가를 보이는 환자로부터 유래된다. 2차 선별에 이런 높은 역가 개별 항체 조제물을 이용하는 것은 일정한 병원균에 대한 과다면역 혈청-반응성 항원의 매우 선택적인 동정을 가능하게 한다.

개별 항체 조제물(또는 선택된 혈청)을 이용한 2차 선별로 1차 선별의 모든 유망한 후보로부터 과다면역 혈청-반응성 항원을 선별적으로 확인하는 것이 중요하다. 따라서, 적어도 10개의 개별 항체 조제물(즉, 선택된 병원균에 감염된 적어도 10명의 개체로부터 유래된 항체 조제물(예, 혈청))이 2차 선별에서 이들 항원을 확인하는데 사용되어야 한다. 물론, 10개 이하의 개별 조제물을 사용하는 것도 가능하긴 하지만, 이 단계의 선별감도가 적은 수의 개별 항체 조제물에서 최적화되지 않을 수 있다. 다른 한편, 과다면역 혈청-반응성 항원(또는 이의 항원성 단편)이 적어도 10개, 바람직하게는, 적어도 30개, 더욱 바람직하게는, 적어도 50개의 개별 항체 조제물에서 인식된다면, 과다면역 혈청-반응성 항원의 동정 역시 적절한 동정이 가능할 만큼 충분히 선별적이다. 과다면역 혈청-반응성은 가능한 많은 개별 조제물(예, 100개 또는 1000개 이상)로 검사할 수도 있다.

따라서, 본원 발명의 방법에 따른 과다면역 혈청-반응성 항체 조제물의 적절한 부분은 바람직하게는, 적어도 10개, 더욱 바람직하게는, 적어도 30개, 가장 바람직하게는, 적어도 50개의 개별 항체 조제물이다. 대안으로, 과다면역 혈청-반응성 항원은 2차 선별에 사용되는 모든 개별 항체 조제물의 적어도 20%, 바람직하게는, 적어도 30%, 더욱 바람직하게는, 적어도 40%로 확인될 수도 있다.

본원 발명의 적절한 구체예에 따라, 2차 선별을 위한 개별 항체 조제물이 만들어지는(또는 항체 조제물로 사용되는) 혈청은 특정 병원균(예, 용해질, 세포벽, 재조합 단백질과 같은 이런 병원균의 조제물)에 대한 역가로 선택된다. 적절하게는, 전체 미생물(전체 용해질 또는 전체 세포)이 ELISA에서 항원으로 이용되는 경우에 일부는 4000 U이상, 특히 6000 U이상의 IgA 역가 및/또는 10,000 U이상, 특히 12,000 U이상의 IgG 역가(U= 단위, 일정한 희석도에서 OD _405nm 판독으로 계산)로 선택된다. 800-1000 U이상의 Ig 역가를 갖는 개별 단백질은 전체 역가만으로 본원 발명에 다른 과다면역 혈청-반응성 항원을 선별하는데 특히 적합하다. 개별 단백질에 대한 설명은 도 9로부터 도출할 수 있다.

본원 발명의 적절한 구체예에서, 일정한 병원균은 스타필로코커스( Staphylococcus ) 병원균, 특히 스타필로코커스 아우레우스( Staphylococcus aureus )와 스타필로코커스 에피데르미디스( Staphylococcus epidermidis )이다. 스타필로코커스( Staphylococcus )는 가벼운 감염에서 치명적인 질환까지 유발할 수 있는 기회적 병원균이다. 많은 스타필로코커스( Staphylococcus )중에서, 적어도 3가지가 인간 질환과 연관한다: 스타필로코커스 아우레우스( S. aureus ), 스타필로코커스 에피데르미디스( S. epidermidis ), 드물지만 스타필로코커스 사프로피티쿠스( S. saprophyticus )(Crossley and Archer, 1997). 스타필로코커스 아우레우스( S. aureus )는 본원 발명에서 본원 발명이 작동하는 방식을 설명하는 전형으로 사용되었다. 이는 인체에 대한 심각한 병원성 효과의 측면에서도 중요한 미생물이다. 스타필로코커스( Staphylococcus ) 감염은 전세계 병원에 점점 더 많은 위협을 강요하고 있다. 스타필로코커스( Staphylococcus )의 출현과 질병 유발 능력은 다중-약물 저항성을 유도하고 지속시키는 항생제의 광범위한 사용과 연관한다. 이런 이유로, 스타필로코커스( Staphylococcus ) 감염에 대한 의학적 치료는 더 이상 항생제에 의존할 수 없다. 따라서, 이들 질환의 치료에서 감염을 예방하기 위한 전술적 변화가 절실히 요구되고 있다. 예방접종에 의한 옵소닉(opsonic)과 중화 유형의 높은 친화성 항체를 유도하는 것은 선천성 면역계가 박테리아와 독소를 제거하는데 효과적이다. 이로 인해 본원 발명에 따른 방법은 스타필로코커스( Staphylococcus ) 항원성 단백질 동정에 최적의 도구이다.

모든 사람에서 스타필로코커스 에피데르미디스( S. epidermidis )가 상재한다. 스타필로코커스 에피데르미디스( S. epidermidis )의 정상적인 번식지는 피부와 점막이다. 가장 병원성이 강한 종인 스타필로코커스 아우레우스( S. aureus )의 주요 번식지는 외비공(anteriornare)과 회음이다. 일부 개체는 동일한 균주를 갖는 영구적인 스타필로코커스 아우레우스( S. aureus ) 보균자가 된다. 보균자 단계는 수술동안 보균자가 비-보균자보다 더욱 쉽게 감염되기 때문에 임상적으로 중요하다. 일반적으로, 코의 확립된 균총은 새로운 균주의 획득을 예방한다. 하지만, 항생제 치료로 민감한 보균자 균주가 제거되면 다른 균주의 상재화(colonization)가 진행될 수 있다. 이런 상황이 병원에서 발생하고 있기 때문에, 환자에 저항성의 병원성 스타필로코커스( Staphylococcus )의 상재화가 진행될 수 있다. 이들 박테리아는 항균제의 광범위하고 부적절한 사용으로 보조되는 선천적 적응성을 갖는다. 따라서, 병원은 약물 저항성이 발생하는데 풍부한 환경을 제공한다(병든 환자간 접촉, 항균제의 광범위한 사용, 병원성 감염). 스타필로코커스 아우레우스( S. aureus )와 스타필로코커스 에피데르미디스( S. epidermidis )는 많은 통상적으로 사용되는 항생제, 특히 메티실린(MRSA)과 반코마이신(VISA)에 저항성을 보이고 있다. 약물 저항성은 공중 보건에 점점 더 위협이 되고 있으며, 조만간 스타필로코커스( Staphylococcus )에 의해 유발된 감염이 항생제에 의해 통제되지 않을 수 있다. 공중 보건에 대한 부작용이외에, 저항성 감염을 치료하는데 독성이 더욱 강하고 가격이 더욱 비싼 약물이 사용되어야 하고 감염된 환자가 더욱 오랜 기간동안 병원에 입원해야 한다는 점에서, 항균제 저항성은 더 높아진 건강 관리 비용의 원인이 되고 있다. 게다가, 효과적인 항생제의 도움에도 불구하고 가장 심각한 스타필로코커스( Staphylococcus ) 감염은 30-50% 치사율을 갖는다.

스타필로코커스( Staphylococcus )는 자연 장벽(피부, 점막)이 파괴될 때, 미생물과 면역계간 자연적 균형이 교란되는 즉시 강력한 병원균으로 변모한다. 코아굴라제(coagulase)-양성 스타필로코커스( Staphylococcus )는 외과 의사들이 오랜 기간동안 우려해온 가장 강력한 병원성 스타필로코커스( Staphylococcus ) 종이다. 이는 빈번하게 수술 상처 감염을 유발하고 농양 형성을 유도한다. 이런 국소적 감염은 전신적으로 확대되어 균혈증과 패혈증을 유발할 수 있다. 특히 바이러스 감염이후와 노년기에 이는 중증 폐렴을 유발할 수 있다. 스타필로코커스 아우레우스( S. aureus )는 또한, 의료 장치, 예를 들면, 혈관내와 경피 카테터(심장 내막염, 패혈증, 복막염), 보철 장치(패혈성 관절염, 골수염)와 관련된 감염의 주요 원인이다. 스타필로코커스 에피데르미디스( S. epidermidis )는 주로 외래 물체의 존재 및 장치의 사용과 관련된 질환, 예를 들면, 카테터 관련된 감염, 척수액 문합 감염, 투석 환자에서 복막염(주로 CAPD), 인공 판막을 가진 개체에서 심장 내막염을 유발한다. 이는 혈관내 장치의 이용과 관련하여 코아굴라제-음성 스타필로코커스( Staphylococcus ) 감염이 빈번하게 발생하는 종양 환자 및 조산아와 같은 면역약화된 개체에서 예증된다. 발병률 증가는 이들 장치의 증가된 이용 및 면역약화된 환자 수의 증가와 연관한다.

다른 덜 알려진 코아굴라제-음성 스타필로코커스( Staphylococcus )인 스타필로코커스 사프로피티쿠스( S. saprophyticus )는 건강한 사람에서 급성 요로 감염을 유발한다. 일부 사례를 제외하고 이들은 16-25세의 여성이다.

스타필로코커스( Staphylococcus )의 병인은 다인적이다. 감염을 개시하기 위하여, 병원균은 부착할 수 있는 숙주의 세포와 조직에 접근해야 한다. 스타필로코커스 아우레우스( S. aureus )는 라미닌, 피브로넥틴, 엘라스틴, 비트로넥틴, 피브리노겐 및 세포외 매트릭스의 일부를 형성하는 많은 다른 분자(세포외 매트릭스 결합 단백질, ECMBP)와 같은 숙주 단백질에 부착을 촉진하는 표면 단백질을 발현한다. 스타필로코커스 에피데르미디스( S. epidermidis )는 외래 물질에 부착을 촉진하는 세포 표면 분자를 구비하고, 이런 기전을 통하여 숙주에 감염을 확립한다. 스타필로코커스( Staphylococcus )가 사용하는 다른 강력한 무기는 분비된 단백질, 예를 들면, 내독소, 외독소, 조직 손상 효소이다. 독소는 숙주 방어에 중요한 면역세포를 죽이거나 오도한다. 여러 상이한 유형의 독소가 감염동안 나타나는 대부분 증상의 원인이 된다.

스타필로코커스 아우레우스( S. aureus )에 대한 숙주 방어는 선천성 면역 기전에 주로 의존한다. 피부와 점막은 스타필로코커스( Staphylococcus ) 침입에 대한 강력한 장벽이다. 하지만, 피부 또는 점막이 일단 파괴되면(상처, 경피 카테터 등), 제 1 선의 비적응성 세포 방어는 보체와 식세포, 특히 다형핵 백혈구(PMN)를 통하여 공동 작용을 시작한다. 이들 세포는 침입 박테리아를 제거하는데 시금석으로 간주할 수 있다. 스타필로코커스( Staphylococcus )는 주로 세포외 병원균이기 때문에, 주요 항-스타필로코커스( Staphylococcus ) 적응성 반응은 면역계의 체액 계통으로부터 유래되고 3가지 주요 기전에 의해 매개된다: 옵소닌화(opsonization)의 촉진, 독소 중화, 부착 저해. 옵소닌화가 특히 중요한 것으로 생각되는데, 그 이유는 옵소닌화가 효과적인 식세포작용에 필요하기 때문이다. 효과적인 옵소닌화를 위하여, 미생물 표면은 IgG 분자의 Fc 단편 또는 활성화된 C3b에 대한 수용체를 통하여 PMN에 의해 인식되는 항체와 보체 인자로 피복되어야 한다. 옵소닌화이후, 스타필로코커스( Staphylococcus )는 식세포작용으로 사멸된다. 더욱이, 스타필로코커스 아우레우스( S. aureus )는 내피 세포에 의해 부착하고 식세포작용-유사 과정에 의해 내재화될 수 있다. 박테리아의 세포 표면에서 특정 항원에 결합하는 항체는 PMN에 부착을 위한 리간드로 작용하고 식세포작용을 촉진한다. 부착성분(adhesin)에 결합된 거의 동일한 항체 및 다른 세포 표면 단백질은 부착을 중화시키고 상재화를 예방할 것으로 기대된다.

세포 매개된 면역이 스타필로코커스( Staphylococcus )에 대한 방어에 현저하게 기여한다는 임상적 증거는 없으며, 이 문제는 아직 해결되지 않고 있다. 하지만, 스타필로코커스 아우레우스( S. aureus )가 초항원이라고 하는 폴리펩티드를 분리함으로써 감염된 숙주의 방어 미세환경을 조작하는 광범위한 분자 대항 수단을 이용하는 것으로 알려져 있는데, 상기 초항원은 병원균-특이적 면역 제거를 개시하는데 필수적인 T-세포와 항원-제시 세포간 다중수용체 신호전달을 표적으로 한다. 초항원은 독성 쇼크 증후군과 식중독에서 핵심적인 역할을 하지만, 통상적인 감염에서 이들의 역할은 아직 확실하지 않다. 게다가, T-세포의 참여 없이는 장기간 지속하는 항체(기억) 반응을 기대할 수 없다. 항-스타필로코커스( Staphylococcus ) 항체의 대부분은 기억 능력없이 T-세포 독립된 항원(협막 폴리사카라이드, 리포테이코산, 펩티도글리칸)을 지향하는 것으로 알려져 있다. T-세포 의존한 단백질성 항원은 장기간 보호 항체 반응을 유도할 수 있다. 이들 스타필로코커스( Staphylococcus ) 단백질과 펩티드는 아직 확인되지 않았다.

전술한 이유로, 스타필로코커스( Staphylococcus ) 감염과의 전쟁에서 전술적 변화가 시급히 필요하다. 감염을 억제하는 한가지 방법은 활성 면역화로 이들을 예방하는 것이다. 스타필로코커스 아우레우스( S. aureus )에 대한 백신 개발은 여러 연구 그룹과 전세계 국립 기관에 의해 시작되었지만, 지금까지 승인을 받은 효과적인 백신은 없다. 항체 결핍 상태가 스타필로코커스( Staphylococcus ) 지속의 원인인 것으로 밝혀졌는데, 이는 항-스타필로코커스( Staphylococcus ) 항체가 숙주 방어에 중요하다는 것을 암시한다. 표면 구성요소를 지향하는 항체(수동 면역으로 추가되거나 또는 활성 예방접종으로 유도된)는 박테리아 부착을 예방하고 독소를 중화시키며 식세포를 촉진할 수 있다. 피브로넥틴 결합 단백질에 기초한 백신은 소에서 유선염(mastitis)에 대한 보호 면역을 유도하는데, 이런 사실은 이런 접근방식이 사람에서도 유효하다는 것을 암시한다. 이를 종합하면, 효과적인 백신은 모든 균주에 의해 발현되고 스타필로코커스 아우레우스( S. aureus )의 세포 표면 구성요소에 대한 풍부한 높은 친화성 항체를 유도할 수 있는 단백질이나 폴리펩티드로 구성되어야 한다는 것을 알 수 있다. 항체는 옵소닌화를 위해서는 IgG1 및/또는 IgG3이어야 하고, 부착과 독소 작용의 중화를 위해서는 IgG 아형과 IgA이어야 한다. 화학적으로 규정된 백신은 전체 세포 백신(약독화 또는 사멸된)과 비교하여 명확하게 우월한데, 그 이유는 TH 세포를 마비시키거나(초항원) 옵소닌화를 저해하는(단백질 A) 스타필로코커스 아우레우스( S. aureus )의 구성요소가 제거될 수 있고 보호 항체를 유도하는 개별 단백질이 선택될 수 있기 때문이다. 적절한 항원의 동정은 효과적인 수동 면역(인화 단클론 항체 요법)을 결과하는데, 이는 위험한 부작용을 유발하는 인간 면역글로불린 투여를 대체할 수 있다. 신생아 스타필로코커스( Staphylococcus ) 감염, 중증 균혈증, 다른 생명-위협 급성 질환이 수동 면역의 일차 표적이다. 효과적인 백신은 일반적인 선택적 수술을 받는 환자 및 특히 혈관내막 장치를 집어넣은 환자에게 상당한 가능성을 제공한다. 게다가, 면역 반응을 감소시키거나 지속적인 보행성 복막 투석을 받은 만성 질환 환자 역시 이런 백신으로부터 혜택을 얻을 수 있다.

스타필로코커스 아우레우스( S. aureus )와 관련된 전형에서, 3가지 별개의 접근방식이 동시에 이용되었다. 이들 3가지 방법은 본원 발명에 따른 방법으로 스타필로코커스( Staphylococcus ) 단백질이나 펩티드와 인간 혈청에 존재하는 항체의 상호작용에 기초한다. 이런 상호작용은 짧은 펩티드(선형 에피토프) 또는 폴리펩티드 도메인(구조 에피토프)이 되는 단백질내 에피토프의 인식에 의존한다. 항원성 단백질은 사전-선택된 혈청의 풀(pool)을 이용한 여러 가지 방법 및 개별 선택된 항원(2차 선별에서)에 의해 확인된다.

고성능 선별이후, 선택된 항원성 단백질은 재조합 단백질 또는 시험관내 번역된 산물(원핵 발현 시스템에서 발견될 수 없는 경우에)로 발현되는데, 대량의 인간 혈청 수집물(>100 감염되지 않은 혈청, >50 환자 혈청)로 면역성의 평가를 위한 일련의 ELISA와 웨스턴 블랏팅 분석으로 검사한다. 바람직한 항원은 세포 표면에 위치하거나 분리된다, 다시 말하면, 세포외적으로 접근가능하다. 세포벽 단백질(예, 세포외 매트릭스 결합 단백질)에 대한 항체는 이중 목적: 부착 저해와 식세포작용 촉진을 달성할 것으로 기대된다. 분비된 단백질에 대한 항체는 독소 중화에 유효하다. 박테리아는 분비된 단백질을 통하여 서로 신호를 전달하는 것으로 알려져 있다. 이들 단백질에 대한 중화 항체는 스타필로코커스( Staphylococcus ) 종간이나 이들 종내에서 성장 촉진 세포내 연결망(cross-talk)을 교란시킨다. 생물정보학(신호, 서열, 세포벽 국소화 신호, 막통 도메인)은 세포 표면 국지화 또는 분비를 평가하는데 매우 유용한 것으로 입증되었다. 이런 실험 접근방식은 인간 혈청으로부터 상응하는 에피토프와 단백질로 항체를 분리하고 다음의 분석에 이들을 시약으로 사용하는 단계로 구성된다: 상이한 조건하에 배양된 스타필로코커스( Staphylococcus )의 세포 표면 염색(FACS, 현미경), 중화 능력의 측정(독소, 부착), 옵소닌화와 식세포작용의 촉진(시험관내 식세포작용 분석).

항체에 의한 선형 에피토프의 인식은 4-5개 aa의 짧은 서열에 기초할 수 있다. 하지만, 이들 짧은 펩티드가 생체내에서 항체를 반드시 유도할 수 있는 것은 아니다. 이런 이유로, 규정된 에피토프, 폴리펩티드, 단백질은 선별된 단백질에 대한 항체를 생체내에서 유도하는 능력을 동물(주로 쥐)에서 추가로 검사할 수 있다. 항체를 유도하는 능력이 입증된 항원은 감염을 예방하는 능력을 동물 모델에서 검사한다.

인간 면역계에 의해 생산되고 인간 혈청에 존재하는 스타필로코커스( Staphylococcus )에 대한 항체는 항원성 단백질의 생체내 발현 및 이들의 면역원성을 지시한다.

따라서, 스타필로코커스 아우레우스( S. aureus )와 스타필로코커스 에피데르미디스( S. epidermidis )로부터 유래된 신규한 과다면역 혈청-반응성 항원은 본원 발명에 따른 방법으로 제조되었다. 본원 발명의 다른 측면에서, 본원 발명은 다음의 표 2a, 2b, 2c, 2d, 3, 4, 5에 기재된 서열, 특히 Seq. ID No. 56, 57, 59, 60, 67, 70, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 85, 87, 88, 89, 90, 92, 95, 96, 97, 99, 100, 101, 102, 103, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 126, 128, 132, 134, 138, 140, 142, 151, 152, 154, 155, 이들의 과다면역 단편에서 선택되는 과다면역 혈청-반응성 항원에 관한다. 또한, 본원 발명은 본원 발명에 따른 방법으로 수득가능하고, 다음의 표 2a, 2b, 2c, 2d, 3, 4, 5에 기재된 서열, 특히 Seq. ID No. 56, 57, 59, 60, 67, 70, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 85, 87, 88, 89, 90, 92, 95, 96, 97, 99, 100, 101, 102, 103, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 126, 128, 132, 134, 138, 140, 142, 151, 152, 154, 155, 이들의 과다면역 단편에서 선택되는 과다면역 혈청-반응성 항원에 관한다.

스타필로코커스 아우레우스( S. aureus )와 스타필로코커스 에피데르미디스( S. epidermidis)로부터 유래된 항원은 본원 발명에 따른 방법으로 추출되었는데, 이들 항원은 제약학적 조성물, 특히 스타필로코커스 아우레우스( S. aureus )와 스타필로코커스 에피데르미디스( S. epidermidis ) 감염에 대한 백신의 제조에 사용될 수 있다. 제약학적 조성물의 제조, 특히 스타필로코커스 아우레우스( S. aureus )와 스타필로코커스 에피데르미디스( S. epidermidis ) 감염에 대한 백신의 제조에 사용되는 스타필로코커스 아우레우스( S. aureus )와 스타필로코커스 에피데르미디스( S. epidermidis )의 이런 과다면역 혈청-반응성 항원의 예는 표 2a, 2b, 2c, 2d, 3, 4, 5에 기재된 서열, 특히 Seq. ID No. 56, 57, 58, 59, 60, 62, 66, 67, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 87, 88, 89, 90, 92, 94, 95, 96, 97, 99, 100, 101, 102, 103, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 126, 128, 130, 132, 134, 138, 140, 142, 151, 152, 154, 155, 158, 이들의 과다면역 단편에서 선택된다.

과다면역 단편은 자체로써 항원성이거나 합텐으로 제공되면 항원성을 나타낼 수 있는 동정된 항원의 단편으로 정의된다. 따라서, 한 개 또는 여러 개의 아미노산 치환을 갖는 항원이나 항원성 단편 역시 이런 단편의 항원성 능력이 치환으로 심각하게 저하되지 않는 조건하에, 다시 말하면, 이런 항원으로 예방접종된 개체에서 적절한 면역 반응을 유도하는데 적합하고 개별 혈청으로부터 유래된 개별 항체 조제물에 의해 확인되는 조건하에 본원 발명에 유효하다.

과다면역 혈청-반응성 항원의 이런 과다면역 단편의 바람직한 예는 표 2a, 2b, 2c, 2d의 “예상 면역원성 aa”, “동정된 면역원성 영역의 위치”, “관련된 영역과의 혈청 반응성” 칼럼의 아미노산 서열 및 표 4와 5의 “추정 항원성 표면 영역”의 아미노산 서열, 특히, 다음의 아미노산 서열 및 상기 서열의 적어도 6개, 바람직하게는, 적어도 8개, 더욱 바람직하게는, 적어도 10개 aa 단편을 포함하는 펩티드에서 선택된다:

서열 번호 55의 아미노산(aa) 12-29, 34-40, 63-71, 101-110, 114-122, 130-138, 140-195, 197-209, 215-229, 239-253, 255-274, 39-94;

서열 번호 56의 aa 5-39, 111-117, 125-132, 134-141, 167-191, 196-202, 214-232, 236-241, 244-249, 292-297, 319-328, 336-341, 365-380, 385-391, 407-416, 420-429, 435-441, 452-461, 477-488, 491-498, 518-532, 545-556, 569-576, 581-587, 595-602, 604-609, 617-640, 643-651, 702-715, 723-731, 786-793, 805-811, 826-839, 874-889, 37-49, 63-77, 274-334;

서열 번호 57의 aa 28-55, 82-100, 105-111, 125-131, 137-143, 1-49;

서열 번호 58의 aa 33-43, 45-51, 57-63, 65-72, 80-96, 99-110, 123-129, 161-171, 173-179, 185-191, 193-200, 208-224, 227-246, 252-258, 294-308, 321-329, 344-352, 691-707, 358-411, 588-606;

서열 번호 59의 aa 16-38, 71-77, 87-94, 105-112, 124-144, 158-164, 169-177, 180-186, 194-204, 221-228, 236-245, 250-267, 336-343, 363-378, 385-394, 406-412, 423-440, 443-449, 401-494;

서열 번호 60의 aa 18-23, 42-55, 69-77, 85-98, 129-136, 182-188, 214-220, 229-235, 242-248, 251-258, 281-292, 309-316, 333-343, 348-354, 361-367, 393-407, 441-447, 481-488, 493-505, 510-515, 517-527, 530-535, 540-549, 564-583, 593-599, 608-621, 636-645, 656-670, 674-687, 697-708, 726-734, 755-760, 765-772, 785-792, 798-815, 819-824, 826-838, 846-852, 889-904, 907-913, 932-939, 956-964, 982-1000, 1008-1015, 1017-1024, 1028-1034, 1059-1065, 1078-1084, 1122-1129, 1134-1143, 1180-1186, 1188-1194, 1205-1215, 1224-1230, 1276-1283, 1333-1339, 1377-1382, 1415-1421, 1448-1459, 1467-1472, 1537-1545, 1556-1566, 1647-1654, 1666-1675, 1683-1689, 1722-1737, 1740-1754, 1756-1762, 1764-1773, 1775-1783, 1800-1809, 1811-1819, 1839-1851, 1859-1866, 1876-1882, 1930-1939, 1947-1954, 1978-1985, 1999-2007, 2015-2029, 2080-2086, 2094-2100, 2112-2118, 2196-2205, 2232-2243, 198-258, 646-727, 2104-2206;

서열 번호 62의 aa 10-29, 46-56, 63-74, 83-105, 107-114, 138-145, 170-184, 186-193, 216-221, 242-248, 277-289, 303-311, 346-360, 379-389, 422-428, 446-453, 459-469, 479-489, 496-501, 83-156;

서열 번호 66의 aa 14-22, 32-40, 52-58, 61-77, 81-93, 111-117, 124-138, 151-190, 193-214, 224-244, 253-277, 287-295, 307-324, 326-332, 348-355, 357-362, 384-394, 397-434, 437-460, 489-496, 503-510, 516-522, 528-539, 541-547, 552-558, 563-573, 589-595, 602-624, 626-632, 651-667, 673-689, 694-706, 712-739, 756-790, 403-462;

서열 번호 67의 aa 49-56, 62-68, 83-89, 92-98, 109-115, 124-131, 142-159, 161-167, 169-175, 177-188, 196-224, 230-243, 246-252, 34-46;

서열 번호 70의 aa 11-20, 26-47, 69-75, 84-92, 102-109, 119-136, 139-147, 160-170, 178-185, 190-196, 208-215, 225-233, 245-250, 265-272, 277-284, 300-306, 346-357, 373-379, 384-390, 429-435, 471-481, 502-507, 536-561, 663-688, 791-816, 905-910, 919-933, 977-985, 1001-1010, 1052-1057, 1070-1077, 1082-1087, 1094-1112, 493-587, 633-715, 704-760;

서열 번호 71의 aa.6-20, 53-63, 83-90, 135-146, 195-208, 244-259, 263-314, 319-327, 337-349, 353-362, 365-374, 380-390, 397-405, 407-415, 208-287, 286-314;

서열 번호 72의 aa 10-26, 31-43, 46-58, 61-66, 69-79, 85-92, 100-115, 120-126, 128-135, 149-155, 167-173, 178-187, 189-196, 202-222, 225-231, 233-240, 245-251, 257-263, 271-292, 314-322, 325-334, 339-345, 59-74;

서열 번호 73의 aa 4-9, 15-26, 65-76, 108-115, 119-128, 144-153, 38-52, 66-114,

서열 번호 74의 aa 5-22, 42-50, 74-81, 139-145, 167-178, 220-230, 246-253, 255-264, 137-237, 250-267;

서열 번호 75의 aa 10-26, 31-44, 60-66, 99-104, 146-153, 163-169, 197-205, 216-223, 226-238, 241-258, 271-280, 295-315, 346-351, 371-385, 396-407, 440-446, 452-457, 460-466, 492-510, 537-543, 546-551, 565-582, 590-595, 635-650, 672-678, 686-701, 705-712, 714-721, 725-731, 762-768, 800-805, 672-727;

서열 번호 76의 aa 5-32, 35-48, 55-76;

서열 번호 77의 aa 7-35, 54-59, 247-261, 263-272, 302-320, 330-339, 368-374, 382-411, 126-143, 168-186;

서열 번호 78의 aa 5-24, 88-94, 102-113, 132-143, 163-173, 216-224, 254-269, 273-278, 305-313, 321-327, 334-341, 31-61, 58-74;

서열 번호 79의 aa 16-24, 32-39, 43-49, 64-71, 93-99, 126-141, 144-156, 210-218, 226-233, 265-273, 276-284, 158-220;

서열 번호 80의 aa 49-72, 76-83, 95-105, 135-146, 148-164, 183-205, 57-128;

서열 번호 81의 aa 6-15, 22-32, 58-73, 82-88, 97-109, 120-131, 134-140, 151-163, 179-185, 219-230, 242-255, 271-277, 288-293, 305-319, 345-356, 368-381, 397-406, 408-420, 427-437, 448-454, 473-482, 498-505, 529-535, 550-563, 573-580, 582-590, 600-605, 618-627, 677-685, 718-725, 729-735, 744-759, 773-784, 789-794, 820-837, 902-908, 916-921, 929-935, 949-955, 1001-1008, 1026-1032, 1074-1083, 1088-1094, 1108-1117, 1137-1142, 1159-1177, 1183-1194, 1214-1220, 1236-1252, 1261-1269, 1289-1294, 1311-1329, 1336-1341, 1406-1413, 1419-1432, 1437-1457, 1464-1503, 1519-1525, 1531-1537, 1539-1557, 1560-1567, 1611-1618, 1620-1629, 1697-1704, 1712-1719, 1726-1736, 1781-1786, 1797-1817, 1848-1854, 1879-1890, 1919-1925, 1946-1953, 1974-1979, 5-134;

서열 번호 82의 aa 6-33, 40-46, 51-59, 61-77, 84-104, 112-118, 124-187, 194-248, 252-296, 308-325, 327-361, 367-393, 396-437, 452-479, 484-520, 535-545, 558-574, 582-614, 627-633, 656-663, 671-678, 698-704, 713-722, 725-742, 744-755, 770-784, 786-800, 816-822, 827-837, 483-511,

서열 번호 83의 aa 4-19, 57-70, 79-88, 126-132, 144-159, 161-167, 180-198, 200-212, 233-240, 248-255, 276-286, 298-304, 309-323, 332-346, 357-366, 374-391, 394-406, 450-456, 466-473, 479-487, 498-505, 507-519, 521-530, 532-540, 555-565, 571-581, 600-611, 619-625, 634-642, 650-656, 658-665, 676-682, 690-699, 724-733, 740-771, 774-784, 791-797, 808-815, 821-828, 832-838, 876-881, 893-906, 922-929, 938-943, 948-953, 969-976, 1002-1008, 1015-1035, 1056-1069, 1105-1116, 1124-1135, 1144-1151, 1173-1181, 1186-1191, 1206-1215, 1225-1230, 1235-1242, 6-66, 65-124, 590-604;

서열 번호 84의 aa 5-32, 66-72, 87-98, 104-112, 116-124, 128-137, 162-168, 174-183, 248-254, 261-266, 289-303, 312-331, 174-249;

서열 번호 85의 aa 4-21, 28-40, 45-52, 59-71, 92-107, 123-137, 159-174, 190-202, 220-229, 232-241, 282-296, 302-308, 312-331, 21-118,

서열 번호 87의 aa 9-28, 43-48, 56-75, 109-126, 128-141, 143-162, 164-195, 197-216, 234-242, 244-251, 168-181;

서열 번호 88의 aa 4-10, 20-42, 50-86, 88-98, 102-171, 176-182, 189-221, 223-244, 246-268, 276-284, 296-329, 112-188;

서열 번호 89의 aa 4-9, 13-24, 26-34, 37-43, 45-51, 59-73, 90-96, 99-113, 160-173, 178-184, 218-228, 233-238, 255-262, 45-105, 103-166, 66-153;

서열 번호 90의 aa 13-27, 42-63, 107-191, 198-215, 218-225, 233-250, 474-367;

서열 번호 92의 aa 26-53, 95-123, 164-176, 189-199, 8-48;

*서열 번호 94의 aa 7-13, 15-23, 26-33, 68-81, 84-90, 106-117, 129-137, 140-159, 165-172, 177-230, 234-240, 258-278, 295-319, 22-56, 23-99, 97-115, 233-250, 245-265;

서열 번호 95의 aa 13-36, 40-49, 111-118, 134-140, 159-164, 173-183, 208-220, 232-241, 245-254, 262-271, 280-286, 295-301, 303-310, 319-324, 332-339, 1-85, 54-121, 103-185;

서열 번호 96의 aa 39-44, 46-80, 92-98, 105-113, 118-123, 133-165, 176-208, 226-238, 240-255, 279-285, 298-330, 338-345, 350-357, 365-372, 397-402, 409-415, 465-473, 488-515, 517-535, 542-550, 554-590, 593-601, 603-620, 627-653, 660-665, 674-687, 698-718, 726-739, 386-402;

서열 번호 97의 aa 5-32, 34-49, 1-43;

서열 번호 99의 aa 10-27, 37-56, 64-99, 106-119, 121-136, 139-145, 148-178, 190-216, 225-249, 251-276, 292-297, 312-321, 332-399, 403-458, 183-200;

서열 번호 100의 aa 5-12, 15-20, 43-49, 94-106, 110-116, 119-128, 153-163, 175-180, 185-191, 198-209, 244-252, 254-264, 266-273, 280-288, 290-297, 63-126;

서열 번호 101의 aa 5-44, 47-55, 62-68, 70-78, 93-100, 128-151, 166-171, 176-308, 1-59;

서열 번호 102의 aa 18-28, 36-49, 56-62, 67-84, 86-95, 102-153, 180-195, 198-218, 254-280, 284-296, 301-325, 327-348, 353-390, 397-402, 407-414, 431-455, 328-394;

서열 번호 103의 aa 7-37, 56-71, 74-150, 155-162, 183-203, 211-222, 224-234, 242-272, 77-128;

서열 번호 104의 aa 34-58, 63-69, 74-86, 92-101, 130-138, 142-150, 158-191, 199-207, 210-221, 234-249, 252-271, 5-48;

서열 번호 106의 aa 12-36, 43-50, 58-65, 73-78, 80-87, 108-139, 147-153, 159-172, 190-203, 211-216, 224-232, 234-246, 256-261, 273-279, 286-293, 299-306, 340-346, 354-366, 167-181;

서열 번호 112의 aa 61-75, 82-87, 97-104, 113-123, 128-133, 203-216, 224-229, 236-246, 251-258, 271-286, 288-294, 301-310, 316-329, 337-346, 348-371, 394-406, 418-435, 440-452;

서열 번호 114의 aa 30-37, 44-55, 83-91, 101-118, 121-128, 136-149, 175-183, 185-193, 206-212, 222-229, 235-242;

서열 번호 116의 aa 28-38, 76-91, 102-109, 118-141, 146-153, 155-161, 165-179, 186-202, 215-221, 234-249, 262-269, 276-282, 289-302, 306-314, 321-326, 338-345, 360-369, 385-391;

서열 번호 142의 aa 9-33, 56-62,75-84, 99-105, 122-127, 163-180, 186-192, 206-228, 233-240, 254-262, 275-283, 289-296, 322-330, 348-355, 416-424, 426-438, 441-452, 484-491, 522-528, 541-549, 563-569, 578-584, 624-641, 527-544;

서열 번호 151의 aa 37-42, 57-62, 121-135, 139-145, 183-190, 204-212, 220-227, 242-248, 278-288, 295-30, 304-309, 335-341, 396-404, 412-433, 443-449, 497-503, 505-513, 539-545, 552-558, 601-617, 629-649, 702-711, 736-745, 793-804, 814-829, 843-858, 864-885, 889-895, 905-913, 919-929, 937-943, 957-965, 970-986, 990-1030, 1038-1049, 1063-1072, 1080-1091, 1093-1116, 1126-1136, 1145-1157, 1163-1171, 1177-1183, 1189-1196, 1211-1218, 1225-1235, 1242-1256, 1261-1269, 624-684;

서열 번호 152의 aa 8-23, 31-38, 42-49, 61-77, 83-90, 99-108, 110-119, 140-147, 149-155, 159-171, 180-185, 189-209, 228-234, 245-262, 264-275, 280-302, 304-330, 343-360, 391-409, 432-437, 454-463, 467-474, 478-485, 515-528, 532-539, 553-567, 569-581, 586-592, 605-612, 627-635, 639-656, 671-682, 700-714, 731-747, 754-770, 775-791, 797-834, 838-848, 872-891, 927-933, 935-942, 948-968, 976-986, 1000-1007, 1029-1037, 630-700;

서열 번호 154의 aa 17-25, 27-55, 84-90, 95-101, 115-121, 55-101;

서열 번호 155의 aa 13-28, 40-46, 69-75, 86-92, 114-120, 126-137, 155-172, 182-193, 199-206, 213-221, 232-238, 243-253, 270-276, 284-290, 22-100;

서열 번호 158의 aa 7-19, 46-57, 85-91, 110-117, 125-133, 140-149, 156-163, 198-204, 236-251, 269-275, 283-290, 318-323, 347-363, 9-42, 158-174;

서열 번호 168의 aa 7-14, 21-30, 34-50, 52-63, 65-72, 77-84, 109-124, 129-152, 158-163, 175-190, 193-216, 219-234;

서열 번호 174의 aa 5-24, 38-44, 100-106, 118-130, 144-154, 204-210, 218-223, 228-243, 257-264, 266-286, 292-299;

서열 번호 176의 aa 29-44, 74-83, 105-113, 119-125, 130-148, 155-175, 182-190, 198-211, 238-245;

이들 단편 각각은 서로 독립적으로 본원 발명의 바람직한 측면을 형성한다.

이에 더하여, 특히 적합한 보조 에피토프가 이들 항원으로부터 유도될 수 있다. 특히 바람직한 보조 에피토프는 표 4와 5에서 “추정 항원성 표면 영역”에 언급된 펩티드 및 T-세포 에피토프인 Seq. ID No. 56의 6-40, 583-598, 620-646, 871-896, Seq ID No. 70의 aa 24-53, Seq. ID No. 74의 aa 240-260, Seq. ID No. 81의 aa 1660-1682, 1746-1790, Seq. ID No. 83의 aa 1-29, 680-709, 878-902, Seq. ID No. 89의 aa 96-136, Seq. ID No. 94의 aa 1-29, 226-269, 275-326, Seq. ID No. 114의 aa 23-47, 107-156, Seq. ID No. 142의 aa 24-53, 이들의 단편에서 선택되는 단편을 포함하는 펩티드이다.

다른 측면에서, 본원 발명은 스타필로코커스 아우레우스( S. aureus )와 스타필로코커스 에피데르미디스( S. epidermidis )에 대한 상기에 동정된 과다면역 혈청-반응성 항원 또는 이의 단편을 포함하는 백신에 관한다. 이런 백신은 스타필로코커스 아우레우스( S. aureus ) 또는 스타필로코커스 에피데르미디스( S. epidermidis )에 대한 한가지이상의 항원을 포함할 수 있다. 선택적으로, 이런 스타필로코커스 아우레우스( S. aureus ) 또는 스타필로코커스 에피데르미디스( S. epidermidis ) 항원은 복합 백신으로 다른 병원균에 대한 항원과도 결합될 수 있다. 적절하게는, 이런 백신은 면역촉진 물질, 적절하게는, 다가양이온 중합체, 특히 다가양이온성 펩티드, 면역촉진 데옥시뉴클레오티드(ODN), 신경활성 화합물, 특히 인간 성장 호르몬, 알루멘, 프레운드 완전 어쥬번트, 프레운드 불완전 어쥬번트, 또는 이들의 혼합물에서 선택된다. 이런 백신은 유전자조작된 미생물, 예를 들면, 대장균( E. coli )의 표면에서 표면 전시 단백질 플랫폼에 전시되는 항원을 포함할 수도 있다.

다른 측면에서, 본원 발명은 상기 규정된 스타필로코커스 아우레우스( S. aureus)와 스타필로코커스 에피데르미디스( S. epidermidis ) 항원 및 이들의 항원 단편중 적어도 한가지에 대한 항체를 포함하는 특이적인 조성물에 관한다. 이들 항체는 바람직하게는, 단클론항체이다.

이런 항체 조성물(다클론 또는 단클론)을 생산하는 방법은 당업자에게 공지된 것이다. 이런 단클론 항체 조성물을 생산하는데 적합한 방법은 다음의 단계로 특성화된다:

- 상기 규정된 스타필로코커스( Staphylococcus ) 항원 또는 이의 단편을 사람아닌 동물에 투여하여 상기 동물에서 면역반응을 유도하고,

- 상기 동물로부터 비장 또는 비장 세포를 떼어내고,

- 상기 비장 또는 비장 세포의 하이브리도마 세포를 만들고,

- 상기 항원에 특이적인 하이브리도마 세포를 선별 및 클론하고,

- 상기 클론된 하이브리도마 세포의 배양 및 선택적인 정제 단계로 항체 조성물을 생산한다.

적절하게는, 비장 또는 비장 세포를 떼어내는 단계는 동물을 죽이는 단계와 연계시킨다.

단클론 항체 또는 이의 단편은 키메라 또는 인화시켜(Graziano et al. 1995) 반복된 투여를 가능하게 할 수 있다. 대안으로, 인간 단클론 항체와 이의 단편은 파아지-전시 라이브러리(McGuinnes et al., 1996) 또는 외래유전자도입 동물(Bruggemann et al., 1996)로부터 수득할 수 있다.

본원 발명으로 동정된 스타필로코커스 아우레우스( S. aureus ) 또는 스타필로코커스 에피데르미디스( S. epidermidis ) 항원에 대한 다클론 항체 조성물을 생산하는데 적합한 방법은 다음의 단계로 특성화된다:

- 상기 규정된 스타필로코커스( Staphylococcus ) 항원 또는 이의 단편을 사람아닌 동물에 투여하여 상기 동물에서 면역반응을 유도하고,

- 상기 동물로부터 항체 함유 체액을 이전하고,

- 상기 항체 함유 체액을 추가로 정제하여 항체 조성물을 생산한다.

이들 단클론이나 다클론항체 조성물은 스타필로코커스( Staphylococcus ) 감염으로 인한 질환을 치료 또는 예방하는 약물의 제조에 사용될 수 있다. 또한, 이들은 진단과 화상 진단 목적으로 사용될 수도 있다.

도 1은 ELISA로 측정된 항-스타필로코커스( Staphylococcus ) 항체 역가에 기초한 혈청의 사전-선별을 도시한다.

도 2는 pMAL4.1에서 LSA50/6 라이브러리 DNA 단편의 크기 분포를 보여준다.

도 3은 비오틴화된 사람혈청으로 MACS 선별을 도시한다. pMAL9.1에서 LSA50/6 라이브러리는 1차 선별(A)에서 10 ㎍ 비오틴화된 인간 혈청으로, 2차 선별(B)에서 1 ㎍ 비오틴화된 인간 혈청으로 선별한다. P.혈청, 환자 혈청; B.혈청, 유아 혈청. 2 ^nd 와 3 ^rd 용리후 선별된 세포 수를 각 선별 라운드에 도시한다.

도 4는 1:5000으로 희석된 환자 혈청의 웨스턴 블랏 분석에서 박테리아 표면 전시로 분리된 특정 클론과의 혈청 반응성을 도시한다.

도 5는 리보솜 전시로 동정된 에피토프를 갖는 환자와 건강한 개체로부터 얻은 혈청을 이용한 펩티드 ELISA를 도시한다.

도 6은 인간 혈청으로 검출된 스타필로코커스 아우레우스( S. aureus ) 표면 단백질의 대표적인 2D 면역블랏을 도시한다. BHI에서 배양된 스타필로코커스 아우레우스( S. aureus )/COL로부터 얻은 800 ㎍ 단백질은 IEF(pI 4-7)와 SDS-PAGE(9-16%)로 용해시키고, 이후 PDF 막으로 옮겼다. 차단후, 상기 막은 혈청 IC35(1:20,000)와 함께 배양하였다. 혈청 IgG의 결합은 항-인간 IgG/HRPO 공액체 및 ECL 발생으로 시각화시켰다.

도 7은 Coomassie Blue로 염색된 스타필로코커스 아우레우스( S. aureus ) 표면 단백질의 대표적인 2D 겔을 도시한다. 스타필로코커스 아우레우스( S. aureus )/COL로부터 얻은 1 ㎎ 단백질은 IEF(pI 4-7)와 SDS-PAGE(9-16%)로 용해시켰다. 혈청학적 프로테옴 분석이후 서열분석을 위하여 선택된 반점(spot)은 표시한다.

도 8A와 8B는 LPXTG 세포벽 단백질의 구조를 도시한다.

도 9는 본원 발명의 박테리아 표면 전시와 프로테오믹스 방식으로 발견된 스타필로코커스 아우레우스( S. aureus )의 신규한 항원이며 가능 표면 부착요소인 LPXTGV에 감염되지 않은 군(N,C)과 감염된 환자(P)에서 IgG 반응을 도시한다.

도 10은 정제된 항-LPXTGV IgG로 스타필로코커스 아우레우스( S. aureus )의 표면 염색을 도시한다.

도 11은 스타필로코커스 아우레우스( S. aureus ) 표면 단백질이 Coomassie Blue에 의해 염색되는 2D 겔을 보여준다(좌측). 초기 로그상까지 배양된 스타필로코커스 아우레우스( S. aureus )/agr의 1 ㎎ 단백질은 IEF(pI 6-11)와 SDS-PAGE(9-16%)에 용해시켰다. 혈청학적 프로테옴 분석이후 서열분석을 위하여 선택된 반점은 표시한다. 상응하는 2D-면역블랏(우측). 동일 조제물의 800 ㎍ 단백질은 2DE로 동시에 용해시키고, 이후 PVDF 막으로 옮겼다. 차단후, 상기 막은 P-풀(1:10,000)과 함께 배양하였다. 혈청 IgG의 결합은 항-인간 IgG/HRPO 공액체 및 ECL 발달로 시각화시켰다.

신규한 스타필로코커스 아우레우스( Staphylococcus aureus ) 항원의 발견

실시예 1: 인간 혈청으로부터 항체의 준비

인간 면역계에 의해 생산되고 인간 혈청에 존재하는 스타필로코커스( Staphylococcus )에 대한 항체는 항원성 단백질의 생체내 발현 및 이들의 면역원성을 지시한다. 이들 분자는 특정 항-스타필로코커스( Staphylococcus ) 항체와 상응하는 스타필로코커스 아우레우스( Staphylococcus . aureus ) 펩티드나 단백질의 상호작용에 기초하는 본원 발명과 같은 방식에서 개별 항원의 동정에 필수적이다. 적절한 항체 레퍼토리에 접근하기 위하여, 인간 혈청이 I. 급성 스타필로코커스 아우레우스( Staphylococcus . aureus ) 감염, 예를 들면, 균혈증, 패혈증, 혈관내와 경피 카테터와 장치의 감염, 상처 감염, 표면과 심부 연조직 감염 환자로부터 수집되었다. 스타필로코커스 아우레우스( Staphylococcus. aureus )는 의학적 미생물학 검사에 의해 원인 물질로 밝혀졌다. Ⅱ. 감염되지 않은 성인으로부터 얻은 혈청 시료 수집물도 본 분석에 포함되었는데, 그 이유는 스타필로코커스( Staphylococcus ) 감염이 일반적이고 항체가 피부와 연조직 감염(절창병, 상처 감염, 치주염 등)에서 스타필로코커스( Staphylococcus )와의 사전 조우로부터 자연 면역의 결과로 존재하기 때문이다.

혈청은 일련의 ELISA 분석으로 스타필로코커스 아우레우스( Staphylococcus . aureus) 항체에 대하여 특성화시켰다. 측정된 역가가 교차-반응성 항체의 합의 결과가 아님을 입증하기 위하여 여러 스타필로코커스( Staphylococcus ) 항원을 사용되었다. 이를 위하여, 전체 세포 스타필로코커스 아우레우스( Staphylococcus . aureus )(단백질 A 결핍) 추출물(상이한 조건에서 배양) 또는 전체 박테리아뿐만 아니라, 개별 세포 웰 구성요소, 예를 들면, 스타필로코커스 아우레우스( Staphylococcus. aureus )로부터 분리된 리포테이코산과 펩티도글리칸이 ELISA 분석에 사용되었다. 더욱 중요하게는, 본원에 따른 인간 혈청 수집물의 더욱 바람직한 특성화를 위하여, 공지된 스타필로코커스( Staphylococcus ) 세포 표면 단백질을 대표하는 재조합 단백질 수집물이 확립되었다.

최근에, IgG뿐만 아니라 IgA 혈청 항체가 PMN의 FcRⅢ 수용체에 의해 인식될 수 있고 옵소닌화를 촉진할 수 있는 것으로 보고되었다(Phillips-Quagliata et al., 2000; shibuya et al., 2000). IgA 항체의 일차적인 역할은 주로 점막 표면에서 중화이다. 혈청 IgA 수준은 이합성 분비 IgA의 품질, 분량, 특이성을 반영한다. 이런 이유로, 혈청 수집물은 항-스타필로코커스( Staphylococcus ) IgG 뿐만 아니라 IgA 수준에 대해서도 분석되었다. ELISA 분석에서 높은 친화성 유형의 항체, 예를 들면, IgG와 IgA를 검출하고 IgM을 회피하는데 매우 특이적인 이차 시약이 사용되었다. IgM 항체의 생산은 일차 적응성 체액 반응 동안 생성되고 낮은 친화성 항체를 결과하는 반면, IgG와 IgA 항체는 친화성 성숙을 이미 거쳤기 때문에 병을 억제하고 예방하는데 더욱 귀중하다.

실험 과정

효소-흡착성 면역 분석(ELISA). ELISA 평판은 코팅 완충액(탄산나트륨 pH 9.2)에서 2-10 ㎍/㎖ 상이한 항원으로 코팅하였다. 혈청의 연속 희석(100-100,000)은 TBS-BSA에서 달성하였다. 매우 특이적인(교차-흡수된) HRP(양고충냉이 과산화효소)-표지된 항-인간 IgG 또는 항-인간 IgA 이차 항체(Southern Biotech)는 제조업자의 권고에 따라 사용하였다(~2,000x). 항원-항체 복합체는 자동화 ELISA 판독기(Wallace Victor 1420)에서 OD _405nm 판독에 기초하여 기질(ABT)의 유색 산물로의 전환을 측정함으로써 정량하였다. 역가는 일정한 희석도에서 비교하였는데, 희석 반응은 선형이었다(표 1). ~100 혈청은 다중 스타필로코커스( Staphylococcus ) 구성요소에 대한 반응성에 기초하여 분류하였는데, 최대 혈청(90 백분위수 이상)은 항원 동정에서 추가 분석을 위하여 선택되었다. 중요하게는, 임상적으로 건강한 개체의 혈청으로부터 유래된 항-스타필로코커스( Staphylococcus ) 항체는 매우 안정한 것으로 확인되었고 3, 6, 9개월후 모든 스타필로코커스( Staphylococcus ) 항원에 대하여 동일하게 높은 ELISA 역가를 제공하였다. 대조적으로, 환자에서 항-스타필로코커스 아우레우스( Staphylococcus . aureus ) 항체는 감소하고, 이후 감염 수주후에 소멸되었다(Coloque-Navarro et al, 1998). 하지만, 환자로부터 얻은 항체는 매우 중요한데, 그 이유는 이들이 본원 발명에 따른 선별동안 ELISA로 검사되거나 또는 면역성으로 확인된 박테리아 항원의 생체내 발현의 직접적인 증거이기 때문이다.

항체 특성화동안 추구되는 이런 포괄적인 접근방식은 독특하고 항-스타필로코커스( Staphylococcus ) 과다면역 혈청의 명확한 동정을 결과한다.

게놈 선별을 위한 항체의 정제. 환자 및 감염되지 않은 개체군으로부터 얻은 5개의 혈청은 전체적인 스타필로코커스( Staphylococcus ) 역가에 기초하여 선택되었다. 대장균( E. coli )에 대한 항체는 전체 세포 대장균( E. coli )(DH5a, pHIE11로 형질전환, 박테리아 전시에 이용된 조건과 동일한 조건에서 배양)과 함께 열 불활화된 혈청을 배양하거나 또는 대장균( E. coli ) 용해질 친화성 크로마토그래피로 제거하였다. 모아진 고갈된 혈청으로부터 매우 진한 IgG 조제물은 제조업자(UltraLink Immobilized Protein G. Pierce)의 권고에 따른 단백질 G 친화성 크로마토그래피로 만들었다. IgA 항체 역시 스트렙타비딘-아가로즈(GIBCO BRL)에 고착된 비오틴-표지된 항-인간 IgA(Southern Biotech)을 사용한 친화성 크로마토그래피로 정제하였다. 고갈과 정제의 효율은 SDS-PAGE, 웨스턴 블랏팅, ELISA, 단백질 농도 측정으로 검사하였다. 프로테오믹스에서는 IgG과 IgA 조제물의 고갈이 필요하지 않은데, 그 이유는 2차 시약이 특이성을 담보하기 때문이다.

실시예 2: 스타필로코커스 아우레우스( Staphylococcus. aureus )의 고도 무작 위 프레임-선택된 소형-단편 게놈 DNA 라이브러리의 산출

실험 과정

스타필로코커스( Staphylococcus ) 게놈 DNA의 준비. 이 방법은 2가지의 이미 공개된 프로토콜(Sohail, 1998, Betley et al, 1984)의 변형으로 개발되었는데, 높은 품질과 대규모로 게놈 DNA를 얻기 위하여 메티실린 저항성 스타필로코커스 아우레우스( Staphylococcus . aureus ) 균주 COL에 맞게 특이적으로 수정되었다. 5 ㎍/㎖ 테트라사이클린으로 보충된 500 ㎖ BHI(Brian Heart Infusion) 배지는 동결된 스탭(stab)의 박테리아를 접종하고 통기하면서 배양하고 37℃에서 18시간동안 교반하였다. 이후, 배양액은 2개의 각 250 ㎖ 부분시료에 수집하고 15분 동안 1600 xg로 원심분리하며, 상층액은 제거하였다. 박테리아 펠릿은 26 ㎖의 0.1 mM Tris-HCl, pH 7.6에 조심스럽게 재-현탁시키고 15분 동안 1600 xg로 한번 더 원심분리하였다. 펠릿은 20 ㎖의 1 mM Tris-HCl, pH 7.6, 0.1 mM EDTA에 재-현탁시키고 무균 50 ㎖ 폴리프로필렌 튜브로 옮겼다. 1 ㎖의 10 ㎎/㎖ 열 처리된 RNase A와 200 U RNase T1을 각 튜브에 첨가하고, 용액은 조심스럽게 혼합하였다. 이후, 250 ㎕ 리소스타핀(lysostaphin)(10 ㎎/㎖ 원료, ddH ₂ O에 새로이 준비)을 튜브에 첨가하고 완전히 혼합하고 지속적인 교반하에 진탕 수조에서 40℃에서 10분 동안 배양하였다. 1 ㎖의 10% SDS, 40 ㎕ 프로테이나제 K(25 ㎎/㎖ 원료)와 100 ㎕ 프로나제(10 ㎎/㎖)의 첨가후, 튜브는 수회 뒤집고 40℃, 진탕 수조에서 5분 동안 배양하였다. 이후, 3.75 ㎖의 5M NaCl과 2.5 ㎖ 세틸 트리메틸-암모늄 불화물 용액(CTAB)(10% w/v. 4% w/v NaCl)을 첨가하고, 튜브는 65℃, 진탕 수조에서 추가로 10분 동안 배양하였다. 시료는 실온으로 냉각시키고 PhOH/CHCl ₃ /IAA(25:24:1)와 CHCl ₃ /IAA(24:1)로 추출하였다. 수상은 조심스럽게 수집하고 새로운 무균 50-㎖ 튜브로 옮겼다. 각 튜브에 1.5 ㎖ Straraclean ^TM 수지를 첨가하고 부드럽지만 완전하게 혼합하며 실온에서 1분 동안 배양하였다. 시료는 원심분리하고, DNA를 함유하는 상층은 깨끗한 50 ㎖-튜브로 수집하였다. DNA는 0.6 x 부피의 이소프로판올을 첨가하여 실온에서 침전시키고 무균 Pasteur 피펫으로 상기 용액으로부터 스풀(spool)하며 80% 차가운 에탄올을 함유하는 튜브로 옮겼다. DNA는 10-12,000 xg로 침전물을 원심분리하여 수집하고, 이후 대기 건조시키고 ddH ₂ O에 용해시켰다.

소규모 게놈 DNA 단편의 준비. 게놈 DNA 단편은 컵-호른(cup-horn) 초음파처리장치(BB5 컵 호른이 구비된 Bandelin Sonoplus UV 2200 초음파처리장치, 100% 파워 출력에서 10 sec. 펄스)로 150 내지 300 bp 크기의 단편으로 또는 적절한 DNase I 처리(Novagen)로 50 내지 70 bp 크기의 단편으로 기계적으로 전단하였다. 초음파처리는 DNA를 150-300 bp 크기의 단편으로 깨뜨릴 때 훨씬 밀집된 단편 크기 분포를 산출하는 것으로 확인되었다. 하지만, 초음파-유도된 유체역학적 전단력에 대한 DNA의 광범위한 노출에도 불구하고, 단편 크기에서 후속적인 감소가 효율적이고 재현적으로 달성되지 않았다. 따라서, Novagen의 샷건 절단 키트를 이용한 적절한 DNase I 처리로 50 내지 70 bp 크기의 단편을 얻었다. 이런 키트에 제공되는 1:20 희석된 DNase I을 준비하고, 60 ㎕ 부피의 MnCl ₂ 존재하에 20℃에서 5분 동안 절단을 실시하여 효소에 의한 이중-가닥 절단을 담보하였다. 반응은 2 ㎕의 0.5M EDTA로 중단시키고, 단편 효율은 2% TAE-아가로즈 겔에서 평가하였다. 이런 처리는 게놈 DNA의 거의 50-70 bp 단편으로의 전체적인 단편화를 결과하였다. 이후, 단편은 각 100 μM dNTP의 존재하에 T4 DNA 중합효소로 2회 평활-말단화시켜 말단의 효율적인 수세(flushing)를 담보한다. 단편은 결찰 반응에 즉시 사용하거나 또는 후속 사용을 위하여 -20℃로 동결하였다.

벡터의 설명. 벡터 pMAL4.1은 카나마이신 저항성 유전자를 보유하는 pEH1 골격(Hashemzadeyh-Bonehi et al., 1998)에 작제하였다. 게다가, 상기 벡터는 다중 클로닝 부위에 클론된 b-락타마제(bla) 유전자를 보유한다. 세포질 막에서 효과적인 분비를 담보하기 위하여, bla 유전자의 앞에 ompA 리더 펩티드 서열을 위치시킨다. Sma I 제한 부위는 라이브러리 삽입에 적합하다. Sma I 부위의 측면에는 상류의 FesI 부위와 하류의 NotI 부위가 위치하는데, 이들은 선별된 단편의 회수에 이용된다. ompA 리더 서열이후에 3개의 제한 부위를 삽입하여, bla 유전자가 -1 개방 해독틀에서 전사되면 NotI 부위이후 15 bp에 종결 코돈이 생성되도록 한다. +1 bp 삽입은 bla ORF를 복구시켜, 앰플리신 저항성의 결과적 획득으로 b-락타마제 단백질이 생성되도록 한다.

벡터 pMAL4.31은 b-락타마제 유전자가 카나마이신 저항성 유전자로 치환된 pASK-IBA 골격(Skerra, 1994)에 작제하였다. 게다가, 상기 벡터는 다중 클로닝 부위에 클론된 b-락타마제(bla) 유전자를 보유한다. 세포질 막에서 효과적인 분비를 담보하기 위하여, 성숙 b-락타마제를 인코드하는 서열의 앞에 ompA 리더 펩티드 서열을 위치시킨다. 더욱이, 성숙 b-락타마제의 첫 12개 아미노산을 인코드하는 서열(스페이서 서열)은 ompA 리더 펩티드 서열을 후행하여 리더 펩티드 절단 부위 직후에 서열의 융합을 회피하는데, 그 이유는 이 영역에서 양성 아미노산의 클러스트가 세포질 막을 통한 이동을 감소 또는 제거하기 때문이다(Kajava et al., 2000). A Sma I 제한 부위는 라이브러리 삽입에 적합하다. Sma I 부위의 측면에는 상류의 FesI 부위와 하류의 NotI 부위가 위치하는데, 이들은 선별된 단편의 회수에 이용된다. 12개의 아미노산 스페이서 서열을 인코드하는 서열이후에 3개의 제한 부위를 삽입하여, bla 유전자가 -1 개방 해독틀에서 전사되면 NotI 부위이후 15 bp에 종결 코돈이 생성되도록 한다. +1 bp 삽입은 bla ORF를 복구시켜, 앰플리신 저항성의 결과적 획득으로 b-락타마제 단백질이 생성되도록 한다.

벡터 pMAL9.1은 lamB 유전자를 pEH1의 다중 클로닝 부위에 클론시켜 작제하였다. 후속으로, 제한 부위 FseI, SmaI, NotI을 포함하는 서열을 lamB에서 154번 아미노산 뒤에 삽입하였다. 이런 삽입을 위한 개방 해독틀은 플라스미드 pMAL4.1 또는 pMAL4.31에서 플라스미드 pMAL9.1까지 FseI과 NotI 절단에 의해 절제되는 프레임-선별된 DNA 단편의 이동이 lamB와 개별 삽입체의 지속적인 개방 해독틀을 산출하도록 하는 방식으로 선택되었다.

벡터 pHIE11은 fhuA 유전자를 pEH1의 다중 클로닝 부위에 클론시켜 작제하였다. 후속으로, 제한 부위 FseI, Xbal, NotI을 포함하는 서열을 fhuA에서 405번 아미노산 뒤에 삽입하였다. 이런 삽입을 위한 개방 해독틀은 플라스미드 pMAL4.1 또는 pMAL4.31에서 플라스미드 pHIE11까지 FseI과 NotI 절단에 의해 절제되는 프레임-선별된 DNA 단편의 이동이 fhuA와 개별 삽입체의 지속적인 개방 해독틀을 산출하도록 하는 방식으로 선택되었다.

프레임 선별을 위한 라이브러리의 클로닝과 평가. 게놈 스타필로코커스 아우레우스( Staphylococcus . aureus ) DNA 단편은 벡터 pMAL4.1 또는 pMAL4.31의 SamI 부위에 결찰시켰다. 재조합 DNA는 DH10B 전기콤피던트(electrocompetent) 대장균( E. coli ) 세포(GIBCO BRL)로 전기천공(electroporation)시키고, 형질전환체는 카나마이신(50㎍/㎖)과 앰피실린(50㎍/㎖)으로 보충된 LB-아가에 도말하였다. 평판은 37℃에서 하룻밤동안 배양하고, 콜로니는 대규모 DNA 추출을 위하여 수집하였다. 대표 평판은 콜로니 PCR 분석과 대규모 서열분석을 위한 콜로니를 수집하기 위하여 안전하게 보관한다. 간단한 콜로니 PCR 분석을 이용하여 대략적인 단편 크기 분포 및 삽입 효율을 처음에 측정하였다. 서열분석 데이터로부터 정확한 단편 크기, 삽입 부위에서 접합 무손상, 프레임 선별 정확도(3n+1 규칙)를 평가하였다.

박테리아 표면 전시를 위한 라이브러리의 클로닝과 평가. 게놈 DNA 단편은 제한 효소 FseI과 NotI으로 스타필로코커스 아우레우스( Staphylococcus . aureus ) 라이브러리를 보유하는 벡터 pMAL4.1 또는 pMAL4.31로부터 절단하였다. 이후, 단편의 전체 집합은 제한 효소 FseI과 NotI으로 절단된 플라스미드 pMAL9.1(LamB) 또는 pHIE11(FhuA)에 이전하였다. 8 bp GC 풍부한 서열을 인식하는 이들 2가지 제한 효소를 사용하여, 벡터 pMAL4.1 또는 pMAL4.31에서 선택된 개방 해독틀은 각 플랫폼 벡터에 유지시킨다. 이후, 플라스미드 라이브러리는 전기천공으로 대장균( E. coli ) DH5a 세포에 형질전환시켰다. 세포는 50 ㎍/㎖ 카나마이신으로 보충된 대형 LB-아가 평판에 도말하고 분명하게 나타나는 단일 콜로니를 산출하는 밀도로 37℃에서 하룻밤동안 배양하였다. 이후, 세포는 이들 평판의 표면으로부터 긁어모으고 새로운 LB 배지로 세척하며 라이브러리 선별을 위한 부분시료로 -80℃에 보관하였다.

결과

프레임 선별을 위한 라이브러리. 2가지 라이브러리(LSA50/6와 LSA250/1)는 각각 대략 50과 250 bp 크기의 pMAL4.1 벡터에서 발생되었다. 양 라이브러리에서, 대략 1 ㎍ pMAL4.1 플라스미드 DNA와 50 ng 단편화된 게놈 스타필로코커스 아우레우스( Staphylococcus . aureus ) DNA를 사용하여 프레임 선별후 총 1-2x10 ⁶ 개의 클론이 달성되었다. LSA50/6 라이브러리의 임의성(randomness)을 평가하기 위하여, 672개의 무작위로 선택된 클론을 서열분석하였다. 생물정보학적 분석에서 이들 클론중에서 1회 이상 나타나는 클론은 없는 것으로 밝혀졌다. 또한, 이들 클론의 90%가 19 내지 70 bp의 크기 범위(25 bp의 평균 크기)에 포함되는 것으로 밝혀졌다(도 2). 672개 서열 모두 3n+1 규칙을 따랐는데, 이는 모든 클론이 적절하게 프레임 선별되었음을 암시한다.

박테리아 표면 전시 라이브러리. 대장균( E. coli )의 표면에서 펩티드의 전시는 프레임 선별 벡터 pMAL4.1에서 전시 플라스미드 pMAL9.1(LamB) 또는 pHIE11(FhuA)까지 LSA50/6 라이브러리로부터 삽입체의 전달을 필요로 하였다. 게놈 DNA 단편은 FseI와 NotI 제한으로 절단하고, 0.1 ㎍ 플라스미드 DNA를 갖는 5 ng 삽입체의 결찰은 2-5x10 ⁶ 클론을 결과하였다. 상기 클론은 LB 평판에서 긁어모으고 추가 증폭없이 동결시켰다.

실시예 3: 박테리아 표면 전시된 게놈 라이브러리와 인간 혈청을 이용하여 스타필로코커스 아우레우스( Staphylococcus. aureus )로부터 고도 면역성 펩티드 서열의 동정

실험 과정

MACS 선별. 일정한 라이브러리로부터 대략 2.5x10 ⁸ 세포는 50 ㎍/㎖ 카나마이신으로 보충된 5 ㎖ LB-배지에 37℃에서 2시간동안 배양하였다. 발현은 30분 동안 1 mM IPTG를 첨가하여 유도하였다. 세포는 새로운 LB 배지로 2회 세척하고, 대략 2x10 ⁷ 세포는 100 ㎕ LB 배지에 재-현탁시키고 Eppendorf 튜브로 옮겼다.

10 ㎍ 비오틴화된 인간 혈청을 세포에 첨가하고, 현탁액은 부드럽게 교반하면서 4℃에서 하룻밤동안 배양하였다. 900 ㎕ LB 배지를 첨가하고, 현탁액은 혼합하고, 이후 4℃에서 10분 동안 6000 rpm으로 원심분리하였다. 세포는 1 ㎖ LB로 한번 더 세척하고, 이후 100 ㎕ LB 배지에 재-현탁시켰다. 스트렙타비딘에 결합된 10 ㎕ MACS 마이크로비드(Miltenyi Biotech, Germany)를 첨가하고, MACS 마이크로비드 세포 현탁액은 자석에 고정된 평형화 MS 칼럼(Miltenyi Biotech, Germany)에 적하하였다(MS 칼럼은 1 ㎖ 70% EtOH로 1회, 2 ㎖ LB 배지로 2회 세척하여 평형화시켰다)

이후, 칼럼은 3 ㎖ LB 배지로 3회 세척하였다. 용리는 자석을 제거하고 2 ㎖ LB 배지로 세척하여 실시하였다. 3 ㎖ LB 배지로 칼럼을 세척한 이후, 2 ㎖ 용출액은 동일 칼럼에 2차 적하하고, 세척과 용리 과정을 반복하였다. 적하, 세척, 용리 과정은 3차로 실시하여, 2 ㎖ 최종 용출액을 결과하였다.

2차 선별은 다음과 같이 실시하였다. 최종 용출액의 세포는 원심분리로 수집하고 50 ㎍/㎖ 카나마이신으로 보충된 1 ㎖ LB 배지에 재-현탁시켰다. 배양액은 37℃에서 90분 동안 배양하고, 이후 1 mM IPTG로 30분 동안 유도하였다. 후속으로, 세포는 수집하고 1 ㎖ LB 배지로 1회 세척하며 10 ㎕ LB 배지에 현탁시켰다. 부피가 감소하기 때문에 1 ㎍의 비오틴화된 인간 혈청을 첨가하고, 현탁액은 부드럽게 교반하면서 4℃에서 하룻밤동안 배양하였다. 모든 다른 단계는 1차 선별에서와 동일하였다. 2차 선별후 선별된 세포는 50 ㎍/㎖ 카나마이신으로 보충된 LB-아가 평판에 도말하고 37℃에서 하룻밤동안 배양시켰다.

서열분석 및 웨스턴 블랏 분석에 의한 선별된 클론의 평가. 선별된 클론은 50 ㎍/㎖ 카나마이신으로 보충된 3 ㎖ LB 배지에서 37℃에 하룻밤동안 배양하여 표준 과정으로 플라스미드 DNA를 준비하였다. 서열분석은 MWG(Germany)에서 또는 TIGR(USA)와 협력하여 실시하였다.

웨스턴 블랏 분석을 위하여 대략 10 내지 20 ㎍ 세포 단백질은 10% SDS-PAGE로 분리하고 HybondC 막(Amersham Pharmacia Biotech, England)에 블랏하였다. LamB 또는 FhuA 융합단백질은 1:5000 희석된 인간 혈청을 일차 항체로, 1:5000 희석되고 HRP에 결합된 항-인간 IgG 항체를 이차 항체로 하여 검출하였다. 검출은 ECL 검출 키트(Amersham Pharmacia Biotech, England)로 실시하였다. 대안으로, 토끼 항-FhuA 또는 생쥐 항-LamB 항체가 융합단백질의 검출을 위한 HRP에 결합된 개별 이차 항체와 함께 일차 항체로 사용되었다.

결과

비오틴화된 인간 혈청을 이용하여 자성 활성화된 세포 분류(MACS)에 의해 세균 표면 전시 라이브러리의 서열화를 하였다. pMAL9.1에 있는 LSA50/6과 pHIE11에 있는 LSA250/1은 비오틴화된 인간 환자 혈청액으로 선별하였다(실시예 1: 인간 혈청으로부터 항체 준비 참고). 선별과정은 실험 과정에서 설명하는 것과 같이 실행하였다. 기준으로는 스타필로코커스 아우레우스( S. aureus )로 대부분 감염이 안된 유아들의 혈청액을 이용하였다. 설명한 조건하에서, 유아 혈청과 비교하여 환자에서 10 내지 50배 더 많은 세포를 지속적으로 선별하였다(도 3). 선별 효능을 평가하기 위해, 약 100개의 선별된 클론을 무작위로 선택하여, 동일한 환자 혈청으로 웨스턴 블랏 분석을 하였다. 이 분석으로 선택된 클론의 30 내지 50%에서 환자 혈청에 있는 항체에 반응성을 보인 반면에 스타필로코커스 아우레우스( S. aureus ) 특정 삽입체가 없는 LamB 또는 FhuA을 발현시키는 기준 균주는 동일한 혈청과 반응을 하지 않았다. 콜로니 PCR 검사에서도 모든 선택된 클론에는 예상 크기 범위의 삽입체를 포함하였다.

무작위로 선택된 클론(스크린당 500 내지 800개) 대다수를 서열화하면 선별에 이용된 인간 환자 혈청에 의해 특이적으로 인지되는 유전자, 이에 상응하는 펩티드 또는 단백질 서열을 확인하였다. 선택된 특정 클론의 반도는 이들 클론에 의해 나타나는 에피토프를 선별하고 인지하는데 이용된 혈청내에 특정 항체의 풍부함 및 친화성을 어느 정도 나타낸다. 이에 대해, 일부 클론(ORF2264, ORF1951, ORF0222, 리파제 및 IsaA)은 90배까지 선택되는데, 이는 이들의 높은 면역원성을 나타낸다. 표 2에 제시한 모든 클론은 단일 클론의 전체 세포 추출물을 이용한 웨스턴 블랏 분석으로 증명되어, 스크린에 이용된 인간 혈청액의 지적한 반응성을 나타낸다. 추가 주목할 것은 스타필로코커스 아우레우스( S. aureus )의 표면에 부착된 또는 분비되는 단백질을 세균성 표면 전시 스크린에 의해 확인되는 유전자 대부분이 인코드한다는 것이다. 이는 스타필로코커스 아우레우스( S. aureus )의 독성에 표면 부착된 또는 분비된 단백질의 예상 역할에 따른다.

상이한 인간 혈청으로 면역원성이 높은 펩티드 서열의 반응성 평가. 10 내지 30개의 다른 인간 환자 혈청은 본원 발명에 따른 스크린에서 발견된 선별된 면역원성 펩티드 서열에 대한 항체가 존재하는지를 평가하였다. 대장균에 의해 발현되는 단백질과의 교차 반응 가능성을 배제하기 위해, 모든 혈청은 FhuA 단백질을 발현하는 대장균 DHa 세포의 전체 세포 용해물질에 선-흡착시켰다.

이와 같은 분석은 표 2에 요약하였고, 도 4에서 볼 수 있으며, 현재 스크린의 유효성을 나타내는 것이다. 짧은 선택된 에피토프는 대다수 환자에서 항체 생산을 유도한다는 것을 볼 수 있다(ORF1618, ORF1632, IsaA, Empbh, 단백질 A). 더 큰 환자의 혈청 세트에 의해 인지되지 않는 이들 펩티드 서열은 매우 면역원성이 큰 단백질 부분일수는 있지만, 재조합 단백질 자체는 각 개별 경우에 대해 그 목적에 따라 시험을 한다.

실시예 4: 리보솜 전시 및 인간 혈청을 이용하여 스타필로코커스 아우레우 스( S. aureus )로부터 게놈 단편의 매우 면역원성이 큰 펩티드 서열 동정

실험 과정

리보솜 전시 선별: 상기에서 설명한 것과 같이, pMAL4.1에 있는 스타필로코커스 아우레우스( S. aureus ) LSA250/1로부터 게놈 라이브러리 2.4ng을 올리고 ICC277 및 ICC202로 PCR 증폭시켜, 리보솜 전시에 이용한다. 올리고 ICC277 (CGAATAATACGACTCACTATAGGGAGACCACAACGGTTTCCCACTAGTAATAATTTTGTTTAACTTTAAGAAGGAGATATATCCATGCAGaCCTTGGCCGGCCTCCC); 그리고 ICC202 (GGCCCACCCGTGAAGGTGAGCCGGCGTAAGATGCTTTTCTGTGACTGG)는 각각 플라스미드 pMAL4.1의 5' 및 3' Fse I-Not I 삽입 부분에 혼성화시킨다. ICC277을 T7 파아지 RNA 중합효소 프로모터, 팔린드롬 서열에 도입시키면, RNA 수준에서 ATG 시작 코돈을 포함하는 T7 파아지의 유전자 10의 해독 개시와 리보솜 결합 부위(RBS)에 줄기형 루프 구조가 형성된다.

올리고 ICC202는 β-락타마제 개방 해독틀의 뉴클레오티드 위치 668에 혼성화시키고, 또한 생성된 RNA의 3' 말단에 줄기형 루프 구조를 도입시킨다. PCR은 50℃ 혼성화 반응 온도에서, 25회 동안 충실성이 높은 PCR 키트(Roche Diagnostic)를 이용하여 실행하고, 다른 조건은 표준 조건에 준한다.

생성된 PCR 라이브러리는 기존에 보고된 것(Hanes et al., 1997)과 유사한 방식으로 단, 하기에서 기재된 정도의 변형을 하여 리보솜 전시에 의해 5회 연속 선별 및 증폭에 이용하였다.

리보솜 전시의 1라운드는 다음의 단계를 포함한다:

2㎍ PCR 생성물을 RiboMax kit(Promega)로 시험관내 전사시키면 ca. 50㎍ A가 생성된다. 시험관내 전사는 4.4㎕ Premix Z(250mM 트리스-아세테이트 pH7.5, 각 아미노산 1.75mM, 10mM ATP, 2.5 mM GTP, 5 mM CAMP, 150mM 아세틸포스페이트, 2.5㎎/㎖ 대장균( E. coli ) tRNA, 0.1㎎/㎖ 폴린산, 7.5% PEG 8000, 200mM 글루타메이트 칼슘, 13.8 mM Mg(Ac) ₂ , 8㎕ S30 추출물(x ㎎/㎖), 용액 내에서 시험관내 전사된 RNA 약 2㎍) 약 22㎕로 37℃에서 9분간 실시하였다. S30 추출물은 Chen et al., 1983에서 설명하는 것과 같이 준비하였다. 그 다음, 샘플을 얼음으로 냉각시킨 튜브로 옮기는데, 튜브에는 35.2㎕ 10% 우유-WBT(TRIS-아세테이트 pH 7.5, 150mM NaCl, 50mM Mg(Ac) ₂ , 0.1% Tween-20, 10% 우유 분말) 및 52.8㎕ WBTH(상기 설명된 것에 추가로 2.5㎎/㎖ 헤파린포함)을 포함하고 있다. 연속하여, 10㎍ 정제된 IgG를 추가하고, 얼음위에서 90분 동안 놓아둔 후에, 30㎕ MAGmol 단백질 G 비드(Milenyi Biotec, 90분간 얼음위에)를 첨가하여, 면역 침전시킨다. 시료는 사전-균질화시킨후 얼음으로 냉각시킨 WBT 완충액으로 5회 씻어낸 μ 칼럼(Miltenyi Biotec)에 얹는다. 그 다음, 20㎕ EB20 용출 완충액(50mM TRIS-아세테이트, 150mM NaCl, 20mM EDTA, 50㎍/㎖ 사카로마이세스 세르비시아( S. cerevisiae ) RNA)을 칼럼에 넣고, 4℃에서 5분간 둔다. 2 x 50 ㎕ EB20을 첨가하여 용출을 완료시킨다. 용출 시료에서 얻은 mRNA는 고순도 RNS 분리 키트(Rochen Diagnostics)를 이용하여 정제시킨다. 역전사를 제조업자의 지시에 따라 Superscript II 역 전사 키트에서(Rochen Diagnostics) 50℃에서 1시간동안 50㎕ 용적에서 60pmol 올리고 ICC202와 함께 역전사를 실시하였다. 이 혼합물 5㎕를 이용하여 상기에서 설명하는 것과 같이 프라이머 ICC202 및 ICC277로 다음과 같이 PCR을 한다.

리보솜 전시 3라운드를 실시하였고, 생성된 선택된 PCR 용액은 제한효소 NotI 및 FseI를 이용하여 절단함으로써 pHIE11(상기에서 설명)로 클론시킨다.

서열화 및 펩티드-ELISA 분석으로 선택된 클론의 평가: 선택된 클론은 37℃에서 3㎖ LB 배지(50㎍/㎖ 카나마이신이 보충됨)상에서 생장시켜, 표준과정에 따라 플라스미드 DNA를 준비하였다. 서열화 과정은 MWG(Germany) 또는 Institute of Genomic Research(TIGR; Rockville, MD, USA)에서 실시하였다. 삽입체에 상응하는 펩티드를 합성하고, 96 웰 미소적정판(Nunc)상에 10mM NaHCO ₃ pH 9.3으로 10㎍/㎖(50㎍)농도로 피복시킨다. 1% BSA/PBS를 이용하여, 37℃에서 차단시킨 후에, 언급한 혈청은 1:200 및 1:1000 희석비로 1% BSA/PBS를 이용하여 희석시키고, 웰에 넣는다. PBS/0.1% Tween-20으로 씻어낸 후에, 비오틴-표지된 항-인간 IgG 2차 항체(SBA)를 첨가하고, 표준과정에 따라 양고추냉이 과산화효소-결합된 스트렙타비딘을 첨가하여 감지할 수 있다.

결과

상기에서 설명한 것과 같은 250-bp 게놈 라이브러리(LSA250/1)를 이용하여 선별한다. 상기에서 설명한 것과 같이, 감염은 되지 않았지만 스타필로코커스 아우레우스( S. aureus )에 대해 높은 역가를 가지는 정제된 IgGs를 이용하여 항원성 펩티드를 선별하였다.

실험과정에 따라 리보솜 전시 선별 및 증폭 3라운드를 실행하였다; 생성된 PCR 용액을 클로닝하고 서열화시켜 완료한다.

다수(700개)의 무작위로 선별된 클론의 서열 분석으로 선별에 이용된 고역가 혈청에 의해 특이적으로 인지되는 유전자 및 이에 상응하는 펩티드 또는 단백질 서열을 확인하였다. 선택된 특정 클론의 빈도는 이들 클론에 의해 제시되는 에피토프 선택 및 인지에 이용된 혈청내에 특정 항체의 일부 빈도 및 친화성을 반영한다. 놀라운 것은, 일부 클론(ORF)은 50배까지 선별되었고, 이는 이들의 높은 면역원성 성질을 나타내는 것이다. 표 2는 ORF 이름, 서열 번호, 본원 발명의 스크린에 의해 확인된 횟수를 나타낸다.

다수의 면역-선별된 ORF를 위해, 확인된 면역원성 부분에 상응하는 펩티드를 합성하고, 확인된 혈청 용액 및 스타필로코커스 아우레우스( S. aureus )에 감염되어 고통을 받는 환자로부터 얻은 다수의 추가 혈청에 대해 이들의 반응성은 펩티드-ELISA에서 검사하였다. 도 5에 있는 그래프의 2개 시료에서는 아우레오리신 및 Pls에서 펩티드 값을 나타낸다. 이들은 고역가 혈청액에 대해 과다면역 반응성을 가질 뿐만 아니라 개별 환자의 혈청에 대해서도 과다면역 반응성을 나타낸다. 선택된 면역원성 부분에 상응하는 합성된 모든 펩티드는 고역가 혈청액에 대해 반응성을 보이고, 표 2에서는 상기에서 설명한 것과 같이, 개별 환자 혈청에 대해 반응성을 보이는 횟수를 나타낸 것이다.

또한, 상기에서 설명한 것과 같이 세균성 표면 전시에 의해서도 확인된 이들 ORF의 경우에는 ORF 내에 실제 면역원성 부분이 리보솜 전시에 의해 확인되는 것과 동일하거나 겹쳐진다는 것이 놀라운 일이다. 표 2에서는 이를 비교하였다.

실시예 5: 혈청학적 프로테옴 분석을 이용한 스타필로코커스 아우레우스( S. aureus)에서 매우 높은 면역원성 항원의 동정

매우 면역원성이 높은 항원 스타필로코커스 아우레우스( S. aureus ) 균주 COL(Shafer and Iandolo, 1979) 및 아가-(Recsei et al., 1986)를 포함하는 스타필로코커스 아우레우스( S. aureus )로부터 얻은 표면 단백질 준비물은 -80℃에 글리세롤 원액에 또는 4℃ BHI (DIFCO) 평판 상에 보관한다. 단일 클론을 이용하여 BHI(“표준 조건”) 또는 RPMI 1640(GibcoBRL)에서 하룻밤 배양 접종물에 이용하고, o/n과 이미노디아세트산(Sigma)으로 처리함으로써 철(“스트레스 조건”)로 방혈시킨다. 새로운 배지에 그 다음날 1:100으로 접종시키고, 세균은 OD ₆₀₀ 에서 0.3 내지 0.7이 되도록 생장시킨다. 세균은 원심분리를 이용하여 수득하고, 얼음으로 냉각된 PBS로 세척하였다. 표면 단백질은 리소스타핀으로 등장성 조건(Lim et al. 1998)하에서 처리하여 준비하였다. 간략하게 설명하면, ~3x10 ⁹ 개 세균(OD ₆₀₀ =1은 약 5x10 ⁷ 개 세균)을 35% 라피노즈(Aldrich Chemical Company), 프로테아제 저해물질(Roche), 5U 라이소스타핀(Sigma)을 포함하는 1㎖ 절단 완충액에 재현탁시킨다. 37℃에서 30분간 배양시킨 후에, 원형질은 저속 원심분리를 이용하여 조심스럽게 침강시킨다. 이와 같은 처리를 함으로써 상층액에 펩티도글리칸 세포벽의 펜타글리신 다리에 공유결합된 표면 단백질을 유리시킬 수 있다(Crossley, 1997). 세포 표면 단백질은 메탄올/클로로포름(Wessel, 1984)으로 침전시키거나 원심분리성 필터-튜브(Millipore)로 농축시킨다. 단백질 시료는 냉동시키고, -80℃에 보관하거나 시료 완충액에 용해시키고, 등전성 포커스(IEF)에 바로 사용한다(Pasquali et al. 1997).

스타필로코커스 아우레우스( S. aureus )에서 준비된 표면 단백질 조제물의 혈청학적 프로테옴 분석. 시료는 a) “스트레스 조건”하에서 생장된 스타필로코커스 아우레우스( S. aureus )/agr; b) “표준 조건”하에서 생장된 스타필로코커스 아우레우스( S. aureus )/COL; c) “스트레스 조건”하에서 스타필로코커스 아우레우스( S. aureus )/COL로부터 획득하였다. “in-gel-reswelling 과정”(Pasquali et al., 1997)을 이용하여, 고정된 pH 농도차(pH 4-7, BioRad)를 포함하는 17㎝ 스트립 상에 로딩하였다. 블랏팅을 위한 겔에 100-800㎍ 단백질을 로딩하고, 예비 겔에는 400-1,000㎍ 단백질을 로딩한다. 등전성 포커싱 및 SDS-PAGE(9-16% 농도차 겔)는 Pasquali et al., 1997에서 설명하는 것과 같이 실행하였다. 웨스턴 블랏팅을 위해, 단백질은 반-건조 블랏팅을 이용하여 PVDF-막(BioRad)으로 옮긴다. 차단 후에(PBS/0.1% Tween 20, 10 건유, 4℃, 16h) 블랏은 혈청(1:2,500-1:100,000으로 차단용액으로 희석함, 표 3참고)과 함께 2시간 동안 배양한다. 세척후에, 혈청 IgG의 특정 결합은 2차 항체로 염소-항-사람-IgG/과산화효소 결합물(1:25,000, Southern Biotech)을 이용하면 눈으로 확인할 수 있고, 화학적발광 기질을 이용하여 현상할 수 있다(ECL ^TM , Amersham). 도 6에서 대표적인 결과를 확인할 수 있다. 30분간 50-65℃에서 2% β-ME/Laemmli 완충액으로 처리하면, 막을 벗길 수 있고, 바로 다른 혈청으로 다시 프로브시키고, 상기에서 설명하는 것과 같이 현상시킨다. 이와 같은 과정을 5회 반복하였다. 환자 또는 건강한 기증자 혈청에서는 신호가 나타나지만 유아 혈청액에서는 나타나지 않는데, 이는 코마시(BioRad)로 착색된 예비 겔(도 7에 샘플을 나타냄)과 일치한다. 스타필로코커스 아우레우스( S. aureus )의 표면 단백질 준비물의 이와 같은 혈청학적 프로테움 분석 결과를 표 3에서 요약하였다.

펩티드-핑거프린트 MALSI-TOF-MS 및 무작위 MS/MS에 의한 단백질 반점의 서열화. 겔 조각들을 번갈아 10㎕ 절단 완충액(10mM NH ₄ HCO ₃ /CAN, 1:1)으로 3회 세척한다. 그 다음, 겔 조각은 10㎕ ACN으로 쪼그라들게 한 후, 2㎕ 프로테아제 용액(0.5㎍/㎕ 트립신, Promega, Madison, USA)으로 재팽창시킨다. 37℃에서 10-12시간동안 절단시킨다. MALDI-TOF-MS를 위해서, 겔 조각으로부터 10㎕ 절단 완충액을 이용하여 단백질을 추출하였다. 상청액은 ZipTip ^TM (Millipore, Bedford, USA)으로 농축시키고, 펩티드는 0.5㎕ 추출 완충액(0.1% TFA/CAN, 1:1)을 이용하여 MALDI 표적상에 용출시킨 다음, 0.5㎕ 매트릭스 용액(HCCA in ACN/0.1% TFA, 1:1)을 첨가하였다. SCOUT384 이온 소스가 갖추어진 REFLEX Ⅲ(Bruker Daltonik, Bremen, Germany)를 이용하여, MALDI-TOF-MS를 실시한다. 가속 볼트는 25kV로 설정하고, 투영 볼트는 28.7kV로 설정하였다. 질량 범위는 700Da 내지 4000Da으로 정한다. 데이터는 SUN Ultra상에서 XACQ 소프트웨어, version 4.0으로 인식하였다. 데이터 분석 과정은 XMASS 소프트웨어, version 4.02(Bruker Daltonik, Bremen, Germany)를 이용하여 실시하였다. 그 결과는 표 3과 4에 요약하였다.

실시예 6. 스타필로코커스 아우레우스( S. aureus )에서 면역원성이 높은 단백 질의 특징

미리 선별된 혈청으로부터 IgG 및 IgA 조제물을 이용하여, 여러 가지 다른 선별 방법으로 확인된 항원은 다음과 같은 방법으로 추가 특징을 조사하였다;

1. 단백질을 정제하는데, 대장균 또는 Gram + 발현 시스템 또는 시험관내 해독 시스템에서 발현되는 재조합 단백질이 가장 적절하고, 인간 일련의 혈청으로 항원성을 평가하였다. 단백질은 생체 정보 분석을 기초하여 변형시키는데, 예를 들면, 신호 펩티드를 나타내는 N-말단 서열을 제거하고; 세포 벽 고정을 하는 C-말단 하류도 제거하고, 정제를 용이하게 하기 위해 태그로 작용하는 여분의 아미노산을 첨가한다(Strep-tagⅡ, His-tag등). 상당수의 혈청을 ELISA에 이용하여, 일정한 단백질에 대해 특정 항체를 포함하는 인간 혈청 부분을 평가하였다(도 9, 실시예). 선택된 항원중 하나는 895aa의 긴 단백질로써, LPXTGV라고 칭하였는데(표 2, 4), 이렇게 명명한 이유는 Gram + 세포 벽 고정 서열 LPXTG을 포함하기 때문이다. 이와 같은 표시는 프로테오글리칸 세포벽에 대해 단백질을 포함하는 LPXTG 모티프를 공유적으로 연결시키는, 솔타제, 트란스-펩티다제에 대한 절단 부위로 작용한다(도 8). LPXTGV는 또한 전형적인 신호 펩티드를 갖고 있다(도 8). Strep-태그된 재조합 단백질로 이와 같은 단백질을 이용한 ELISA 데이터는 이와 같은 단백질은 다량의 혈청에서 매우 면역원성이 크다는 것을 설명한다(다른 재조합 단백질에 대해 높은 역가).(도 9). 중요한 것은 급성 스타필로코커스 아우레우스( S. aureus )에 감염된 환자는 건강한 사람보다 이들 항-LPXTGV 항체 더 많이 생산하고, 이는 단백질이 생체내 감염동안에 발현된다는 것을 나타낸다. 개별 항원성 단백질의 전체적인 ELISA 역가를 비교하였고, 대부분 개체에서 가장 높은 항체 수준을(가장 면역원성이 큰) 나타내는 것이 적당하다(생체내에서 대부분의 균주에 의해 단백질이 발현된다). 개별 환자에서 생산되는 스타필로코커스 아우레우스( S. aureus )에 대한 항체의 항원 특이성과 질(종류, 타입, 기능, 비기능)은 감염 부위, 수반되는 만성 질환(당뇨병), 장기적인 상태(가령, 맥관내 장치), 개체의 면역 반응 등에 따라 다양하기 때문에, 각 혈청에 속하는 의료기록을 이용하여, 상이한 환자군에서 감지되는 차이점에 주의한다. 또한, 각 환자 혈청은 혈청 샘플링 시기에 환자에서 분리한 병인 균주와 같이 수반된다.

2. 특이적인 항체는 추가 특징을 조사하기 위해 정제하였다. 재조합 단백질의 순도 및 완전성을 점검하였다(SDS-PAGE상에서 실버 착색과 비교하여 웨스턴 블랏 분석으로 N-말단 Strep-tag 감지). 항원은 태그를 통하여 고정시켜, 친화성 매트릭스를 만들고, 매우 반응성이 큰 혈청을 이용하여 특정 항체의 정제에 이용한다. 캡쳐 항원으로 예를 들면, Strep-태그된 LPXTGV를 이용하여, IgG 125㎎으로부터 20㎍의 항체를 정제하였다. ELISA 데이터를 기초하여, 항-LTA 및 항-펩티도글리칸활성(분절안된 IgG에 많은)을 가지고 있지 않은 순수한 정제물을 얻는다. 이들 항체를 이용하여, FACS 및 형광 현미경으로 세포 표면 위치를 확인한다(도 10).

3. 임상 분리물 내에서 유전자 발생

이상적인 백신 항원은 백신이 제공되는 표적 유기체의 모든 또는 대부분의 주요 균주에 존재하는 항원이 될 수 있을 것이다. 확인된 스타필로코커스 아우레우스( Staphylococcus aureus ) 항원을 인코드하는 유전자가 스타필로코커스 아우레우스( S. aureus ) 균주에 산재되어 발생하는지를 확인하기 위해, 관심의 대상이 되는 유전자에 특이적인 프라이머와 독립적인 스타필로코커스 아우레우스( S. aureus ) 분리체상에서 PCR을 실행하였다. 스타필로코커스 아우레우스( S. aureus ) 분리체는 다양한 스타필로코커스 아우레우스( S. aureus )에 감염된 환자로부터 수득하였다. 또한, 건강한 운반자 및 여러 가지 lab 균주에서 분리한 몇 가지 비강 분리체를 수득하고, 분석하였다. spa 및 coa 유전자(Goh et al. 1992, Frenay et al., 1994, vanden Bergh et al. 1999)의 제한효소 단편 길이 다양성(RFLP)에 따라 균주를 분류하였다. 이들 결과로부터 30가지 상이한 균주-24개 환자 분리체, 3개 비강 분리체, 3개 lab 균주-가 확인되었다. 선택된 항원의 유전자 분포를 확인하기 위해, 이들 30개 균주의 게놈 DNA를 선택된 에피토프에 인접한 유전자 특이적 프라이머로 PCR 시킨다(ORF1361: 서열번호 187 및 188; ORF2268: 서열 번호 193 및 194; ORF1951: 서열 번호 195 및 196; ORF1632: 서열 번호 181 및 182; ORF0766: 서열 번호 183 및 184; ORF0576: 서열 번호 185 및 186; ORF0222: 서열 번호 189 및 190; ORF0360: 서열 번호 191 및 192). PCR 생성물을 겔 전기영동을 이용하여 분석함으로써 정확하게 예상된 크기의 생성물을 확인할 수 있다. ORF 1361, 2268, 1951, 1632, 0766, 0222는 테스트한 균주 모두(100%)에 존재하였고, ORF0576는 97%에 존재하였다. 하지만, ORF0360은 균주의 71%에만 존재하였다. 따라서, ORF 1361, 2268, 1951, 1632 0766, 0576, 0222 각각은 각각 스타필로코커스 아우레우스( S. aureus ) 분리물간에 요구되는 산재성을 가진다.

이들 항원(또는 이들 항원성 단편 특히 확인된 단편)은 스타필로코커스 아우레우스( S. aureus )에 대한 백신 프로젝트에 사용하기에 적합하다.

4. 선택된 항원의 ORF내에 무차별적인 HLA-클래스 II 보조 에피토프의 동정

사람의 혈청에 있는 항체에 의해 인지되는 것을 바탕으로 확인된 항원에 상응하는 ORF는 대부분이 선형 T-세포 에피토프를 포함하였다. 특히 본원 발명에서 놀라운 발견은 심지어 건강한 감염안된 그리고 콜로니가 형성안된 개체도 상당히 높은 역가를 나타내었는데(일부 항원의 경우에는 >100,000, 실시예 5 참고), 이는 1년 이상 안정하였다. 이는 CD4+ 보조-T-세포에 의해 대부분이 중개되는 T-세포 의존성 메모리가 존재한다는 것을 의미하는 것이다. 상응하는 HLA 클래스 II 보조-에피토프의 분자 정의는 면역학적 메모리를 유도할 수 있는 합성 항-스타필로코커스 백신을 고안하는데 유용하다. 이와 같은 시나리오에서, 스타필로코커스 항원에서 유도된 보조-에피토프는 “이들 항원 또는 이 항원의 단편에 대해 B-세포 반응에 ”동종과 같은 도움“을 제공한다. 또한, 이와 같은 보조-에피토프를 이용하면 탄수화물과 같은 T-독립 항원(공액체 백신)에 대한 메모리를 유도할 수 있다. 한편, 세포내에서 발생하는 스타필로코커스는 HLA 클래스 I 제한된 에피토프를 인지하는 CD8+ 세포독성 T-세포를 이용하면 제거할 수 있다.

다양한 각종 도메인에 있는 연산으로 T-세포 에피토프를 예상할 수 있다http://bimas.dcrt.nih.gov/molbio/hla bind/(Parker et al. 1994) http://134.2.96.221/scripts MHCServer.dll/home.htm(Rammensee at al. 1999), http://mypage.ihost.com/usinet.hammen76/(Sturniolo et al. 1999). 후자의 예상 연산으로 혼잡한 보조-에피토프 즉, 여러 가지 HLA 클래스 II 분자에 결합하는 펩티드와 같은 에피토프를 확인할 수 있는 가능성을 제공한다. 스타필로코커스 항원내에 매우 혼잡한 보조-에피토프를 확인하기 위해, 서열 번호 64(IsaA), 서열 번호 114(POV2), 서열 번호 89(ORF0222), 서열 번호 70(LPXTGIV), 서열 번호 56(LPXTGV), 서열 번호 142(LPXTGVI), 서열 번호 81(ORF3200), 서열 번호 74(ORF1951), 서열 번호 94(Empbp), 서열 번호 83(Autolysin), 서열 번호 58(ORF2498)에 상응하는 ORF를 TEPITOPE 패키지(http://mypage.ihost.com/usinet.hamme76/(Sturniolo et al. 1999))를 이용하여 분석하였다. 25개의 흔한 DR-대립형질에 대해 분석하였고, 펩티드는 a)적어도 10/25개 대립형질에 대해 강한 결합물질(1%선) 또는 b) 적어도 17/25 대립형질에 대해 중간정도의 결합물질인 것으로 예상된다면 선별하였다.

다음은 한가지 또는 여러 가지 혼잡한 보조-에피토프를 포함하는 펩티드를 선별한 것이다;

서열 번호 56: pos. 6-40, 583-598, 620-646, 871-896

서열 번호 58: 선별 기준에 맞는 펩티드 없음.

서열 번호 64: 선별 기준에 맞는 펩티드 없음.

서열 번호 70: pos. 24-53

서열 번호 74: pos. 240-260

서열 번호 81: pos. 1660-1682, 1746-1790

서열 번호 83: pos. 1-29, 680-709, 878-902

서열 번호 89: pos. 96-136

서열 번호 94: pos. 1-29, 226-269, 275-326

서열 번호 114: pos. 23-47, 107-156

서열 번호 142: pos. 24-53

상응하는 펩티드 또는 이의 단편(예를 들면, 겹쳐지는 15-mer)을 합성하고, 시험관내에서 다양한 HLA 분자에 결합하는 능력에 대해 테스트하였다. 이들의 면역원성은 펩티드(항원)-유도된 증식(BrdU 또는 ³ H-티미딘 결합) 또는 시험관내에서 T-세포의 사이토킨(ELIspot, intracellular cytokine staining) 분비를 평가함으로써 테스트할 수 있다(Mayer et al. 1996, Schmittel et al. 2000, Sester et al. 2000). 이에 대해, 최근에 감염되거나 콜로니 형성이 전혀 없었던 건강한 개체에 대해 상이한 스타필로코커스 감염 또는 콜로니가 형성된 환자군에서 선별된 혼잡한 펩티드 또는 이의 단편 또는 스타필로코커스 항원에 T 세포 반응성을 정량 및 정성 분석하는 것이 흥미롭다. 또한, 이와 같은 집단에서 관찰된 T-세포 반응의 양과 질, 항체 역가간에 상관관계를 예측할 수 있다. 또는, 예상된 펩티드의 면역원성은 HLA-유전자전이된 쥐에서 테스트하였다

스타필로코커스 항원내에 HLA 클래스 I 제한된 에피토프를 확인하는 데에도 비슷한 방법이 이용될 수 있다.

스타필로코커스 아우레우스( S. aureus )로부터 하나 또는 복수의 불규칙한 T- 보조 에피토프를 나타내는 합성 펩티드

서열 번호 56(LPXTGV), 서열 번호 70(LPXTGIV), 서열 번호 74(ORF1hom1), 서열 번호 81(EM_BP), 서열 번호 83(Autolysin), 서열 번호 89(ORF1hom2), 서열 번호 94(EMPBP), 서열 번호 114(PVO2), 서열 번호 142(LPXTGVI)의 지정된 부분에 있는 부분적으로 겹쳐지는 펩티드를 합성하였다. 개별 펩티드 서열은 표 5에 제공하였다. 모든 펩티드는 Fmoc 화학을 이용하여 합성하고, HPLC 정제시키고, 질량 스펙트럼을 이용하여 분석하였다. 냉동건조된 펩티드를 DMSO에 용해시키고, -20℃에 5-10mM 농도로 저장하였다.

시험관내에서 HLA 분자에 불규칙한 T-보조- 에피토프를 나타내는 합성 펩티드 의 결합

항원을 제공하는 세포의 표면에 HLA 분자에 펩티드 결합은 T 세포 활성을 위한 필수조건이다. 결합은 HLA 클래스 II 분자의 재조합 가용성 부분을 이용하여, 시험관내에서 두 가지 독립적인 생화학적인 검사를 이용하여 평가하였다. 한 방법은 테스트되는 펩티드에 의해 라벨된 기준 펩티드가 농도 의존성 경쟁적인 치환을 측정하는 것이다. 두 번째 검사는 친화성이 높은 또는 중간정도의 리간드의 결합에서 SDS-안정한 복합체 형성에 기초한 것이다. 이 두 가지 검사에서 얻은 결과는 표 5에 제공하였다.

가용성 HLA 분자(DRA1*0101.DRB1*0101 및 DRA1*0101/DRB1*0401)는 SC-2 세포에서 발현되고, Aichinger et al., 1997에서 설명하는 것과 같이 정제하였다. 경쟁적인 검사(Hammer et al. 1995)를 하기 위해서는, HLA 분자를 50 내지 200ng/웰 농도로 제공하였다. DRB1*0101의 경우에는 비오틴화된 지시물질 펩티드 HA(PKYVKQNTLKLAT, Valli et al. 1993)를 0.008μM 농도로 이용하였다. DRB1*0401의 경우에, 비오틴화된 지시물질 펩티드 UD4(YPKFVKQNTLKAA, Valli et al. 1993)를 0.03 내지 0.06μM농도로 이용하였다. 테스트 펩티드는 0.02nM 내지 200μM 농도로 희석하여 이용하였다. 분자, 지시물질, 테스트 펩티드를 37℃, pH7에서 하룻밤동안 배양시켰다. 테스트 및 기준 펩티드(공지의 높은 친화성 결합물질 HA 및 UD4를 포지티브 기준으로 이용하였다)를 연속하여 희석시킴으로써 수득한 HLA:펩티드 복합체를 항체 L243(이형이량체와 정확하게 연합되어 형성된 경우에만 적합한 에피토프를 인지하는 것으로 알려진)이 피복된 ELISA 플레이트에 포획시켰다. 결합된 비오틴은 기질로 NBT/BCIP 정제(Sigma)와 스트렙타비딘-알칼린 포스포타제 공액물(Dako)을 이용하여 표준 발색 감지를 이용하여 결합된 비오틴을 측정하고, Victor 판독기(Wallac)상에서 OD 값을 판독한다.

IFNg ELIsot 분석으로 평가된 혼잡한 T 보조에 대한 T 세포 반응

항원 자극시에 T 세포는 증식을 시작하고, 인터페론 감마(IFNg)와 같은 사이포킨을 분비하기 시작한다. 스타필로코커스 아우레우스( S. aureus )내에 에피토프를 특이적으로 인지하는 인간 T 세포는 IFNg-ELIspot(Schmittel et al. 2000)에 의해 감지된다. 강력한 항-스타필로코커스 아우레우스 IgG 반응을 가지는 건강한 개체로부터 PBMC는 Ficoll 밀도차 원심분리를 이용하여 정맥혈로부터 50-200㎖를 분리하였고, 이는 냉동 및 해동 후에 이용하였다. 세포는 96-웰 플레이트 상에 200,000/웰 농도로 접종한다. 펩티드는 개별 항원에 상응하는 혼합물로 첨가되는데, 각 경우에 농도는 10㎍/㎖로 한다. 콘카나발린 A(Amersham), PPD(튜베르큘린 정제된 단백질 유도체, Statens Serum Institute)는 검사의 포지티브 기준으로 사용하고, 펩티드가 전혀 존재하지 않는 검사 배지는 네거티브 기준으로 이용한다. 항-인간 IFNg 단클론항체 B140(Bender Med Systems)으로 피복시킨 Multi Screen 96웰 여과 플레이트(Millipore)로 하룻밤동안 배양시킨 후에, ELIspot는 비오틴화된 항-인간 IFNg 단클론 항체 B308-BT2(Bender Med Systm), 스트렙타비딘-알칼리 포스포타제(DAKO), BCIP/NBT 알칼리 포스포타제 기질(SIGMA)을 이용하여 발생시킨다. 플레이트 자동 판독기(Bioreader 2000, BIO-SYS)를 이용하여 반점을 헤아린다. 검사 배지(네거티브 기준, 일반적으로 100,000 세포당 10개미만의 반점)만으로 자극을 한 세포와 웰에 있는 카운트된 반점은 배경으로 간주하고, 펩티드와 웰에서 카운트된 반점을 뺀다.

[표 5]

스타필로코커스 아우레우스( S. aureus ) 항원에 포함된 불규칙한 T 보조 에피토프

¹⁾ 가용성 DRA1*0101/DRB1*0401 분자에 결합은 경쟁 검사로 결정한다(+, ++: 결합; -: 200μM 테스트 펩티드까지 경쟁 없음: nd: 실시하지 않음)

²⁾ 강력한 항-스타필로코커스 아우레우스 IgG 반응을 보이는 5명의 건강한 개체에서 얻은 결과.

5. 항원을 생쥐에 투여하고-이들 단백질에 대한 항체를 측정할 수 있다.

6. 동물 모델에서 예방접종을 통하여 항원에 의해 유도된 항체의 보호 능력을 평가하였다.

5와 6은 당 기술 분야에 지식을 가진 자가 흔히 이용할 수 있는 방법이다.

실시예 7: 응용

A) 효과적인 백신은 일반적으로 선택적 외과술을 받는 환자, 특히 맥관내 장치를 수용해야할 환자에게 상당한 잠재성을 제공한다. 면역 반응이 감소된 만성질환으로 고통을 받는 환자 또는 지속적인 보행 투석을 받는 환자는 본원 발명에 따른 면역원성 혈청-반응성 항원으로 스타필로코커스 아우레우스( S. aureus ) 백신으로 이익을 얻을 수 있다. 관련 항원의 동정은 효과적인 수동 면역화(인화 단클론 항체 치료법)를 생성하는데 도움이 될 것이고, 이는 위험한 부작용이 수반되는 인간 면역글로불린 투여에 대체 요법이 될 수 있다. 따라서, 효과적인 백신은 일반적으로 선택적 외과술을 받는 환자, 특히 맥관내 장치를 수용해야할 환자에게 상당한 잠재성을 제공한다.

스타필로코커스 아우레우스( S. aureus )는 많은 상이한 질환을 유발시킬 수 있다.

1. 폐혈증, 박테리아혈증

2. 혈액투석된 환자 - 박테리아 혈증, 폐혈증

3. 복막 투석 혼자 - 복막염

4. 맥관내 장치를 한 환자(심장 수술) 심장내막염, 박테리아혈증, 폐혈증

5. 보철 장치를 한 정형외과 환자 -폐혈증 관절염

6. 일반적인 예방 백신

B) 수동성 및 능동성 백신, 두 가지 경우 모두 특별한 주의를 요하는데, T 세포의 경우에는 후자에 주의를 요한다; 면역접종 과정동안에 강력한 T 보조 반응을 유도하여, 효과적인 체액 반응 및 면역학적 메모리를 얻을 수 있다. 지금까지, T-세포가 스타필로코커스 아우레우스( S. aureus ) 감염을 제거하는데 중요한 역할을 할 것이라고 보여주는 직접적인 증거는 없었고, 적절하게 제기된 적도 없다. 단백질성 항원에 대한 효과적인 체액 반응은 T 보조가 연관이 되었을 것이고, 메모리를 개발하는 것이 필수적일 것이다. 고유 CD4+ 세포는 Th1 또는 Th2 세포로 분화할 수 있다. 고유 면역학적 반응(사이토킨)이 이와 같은 결정에 영향을 줄 수 있기 때문에, T-세포와의 연관성은 자연적인 감염 과정동안에 면역 반응을 손상시키는 성분을 포함하지 않은 백신 소단위로 건강한 개체를 면역화시키는 것에 관련된 급성, 연속 감염과는 다를 것이다. Th1 또는 Th2 반응을 유도한 결과는 상당한 것이다. Th1 세포는 세포-주액된 면역원성을 유도하고, Th2 세포는 체액 면역원성을 제공한다.

C) 예방과 치료 백신

예방: 감염 전에 위험이 높은 군의 사람에게 활성이 있는 백신 주사/수동적인 면역화

치료: 이미 병든 환자 군에게 수동적인 백신제공

비강을 통한 운반을 없애기 위한 활성 예방접종

* 구체적인 응용 사례

MRSA 보균의 제거 및 의료 인원의 상재화 예방

외래환자의 콧구멍에 스타필로코커스 아우레우스( S. aureus )의 운반 비율은 10 내지 40%이다. 입원 환자나 구성원들은 더 높은 보균율을 가진다. 혈액 투석을 하는 환자, 당뇨, 약물 중독, 다양한 상태의 피부병이 있는 환자에는 그 비율이 특히 높다. MRSA 감염 위험이 가장 높은 혼자는 3차-치료 병원에 있는 환자, 특히, 노인, 중환자실에 있는 면역약화된 혼자, 화상 환자, 외과적인 상처가 있는 환자 및 정맥내 카테터를 가진 환자 등이다.

ELISA 데이터는 스타필로코커스 아우레우스( S. aureus )에 대한 뚜렷한 IgA 반응이 존재한다는 것을 강력하게 제시하는데, 이는 기존 문헌에서는 분명하지 않거나 공지되지 않은 사실이다. 주요 점막 면역 반응이 중화 활성을 갖는 IgA의 생산이기 때문에, 고순도 IgA 조제물로 동정된 스타필로코커스 에피토프 및 항원이 효과적인 점막 백신을 유도한다는 것은 명백하다.

● 명백한 징후: 수술을 실시하는 부서(특히, 정형외과, 외상, gen. 외과술)의 모든 사람에게 위험.

● 예방접종에 익숙한 집단(의사 및 간호사)

● 스타필로코커스 아우레우스( S. aureus )의 균주를 비강내 운반자로 확인된 건강센터 직원은 세균이 제거될 때까지 뮤피로신 및 리팜피신 치료를 받는다. 일부의 경우에는 효과가 없고 시간이 소요된다.

● 이용할 수 있는 동물 모델: 비강 운반용 생쥐 모델이 있다.

[표 1]

감염안된 개체로부터 혈청의 다중 스타필로코커스 단백질에 대한 ELISA 역가

표 1. 감염안된 개체로부터 혈청의 다중 스타필로코커스 단백질에 대한 ELISA 역가

항-스타필로코커스 항체 수준을 표준 ELISA로 개별적으로 측정하는데, 이때, BHI 배지(BHI), 리포테이코산(LTA), 펩티도글리칸(PG), 13개의 재조합 단백질을 제시하는 세포 표면 및 클럼핑 인자 A, B(Clfa, ClfB)와 같은 분비된 단백질, 피브로넥틴 결합 단백질(FnBPA), SD-반복 단백질(SdrC, sdrE), MHC 클래스 II 유사성 단백질(map-w), 엘라스틴-결합 단백질(EBP), 에노라제(세포 표면에 위치하고, 면역원성으로 알려짐), 철 운반 리포프로테인(LP3019, LP342), 솔타제(srtA), 코아굴라제(coa), 세포외 피브리노겐-결합 단백질(fib)에서 생장시킨 스타필로코커스 아우레우스( S. aureus )에서 준비된 전체 용해질을 이용한다. FnBPA으로부터 5개의 면역우성 D 반복 도메인중 2개를 나타내는 두 개의 짧은 합성 펩티드(D1+D3)가 항원으로 포함된다. 개별 혈청은 IgG 역가에 기초하여 순서를 정하고, 1-9까지 순서를 부여한다. 숫자 1은 가장 높은 역가에 부여하고, 숫자 8 또는 9는 일정한 항원에 대해 테스트된 모든 혈청에서 8번째나 9번째가 되는 혈청에 부여된다. 이는 혈청의 상위 20%(8-9/40) 분석 결과이다. 항-스타필로코커스 항체에 대해 가장 높은 반응성이 있다는 것을 의미하는 다섯 개 “베스트 혈청”은 숫자 1-8을 기초하여 선별한다. ***의미는 특정 항원에 대한 항체 반응성이 예외적으로 높다는 것을 의미한다(en 번째 반응성 혈청에 대한 >2x ELISA 유닛).

표 2a: 세균성 표면 및 리보솜 전시에 의해 확인된 면역원성 단백질: 스타필 로코커스 아우레우스( S. aureus )

세균성 표면 전시: 환자 혈청 1(655)의 fhuA 내에 A, LSA250/1 라이브러리; B, lamB 내에 LSA50/6 라이브러리, 환자 혈청 1(484); C, fhuA 내에 LSA250/1 라이브러리, IC 혈청 1(571); E, lamB 내에 LSA50/6 라이브러리, IC 혈청 2(454); F, lamB 내에 LSA50/6 라이브러리, 환자 혈청 P1(1105); G, lamB 내에 LSA50/6 라이브러리, IC 혈청 1(471); H, fhuA 내에 LSA250/1 라이브러리, 환자 혈청 1(IgA, 708); 리보솜 전시: D, LSA250/1 라이브러리, IC 혈청(1686). *는 조사된 33개 중에서 18회 확인됨; 따라서 스크린 C에서 제거됨. **, 5개 이상 아미노산보다 더 긴 항원 서열 예측은 프로그램 ANTIGENIC(Kolaskar and Tongaonkar, 1990)을 이용하여 실행하였고; #, ORF에 2개씩 존재하는 동일한 서열; ##, 데이터베이스에 없는 서열(TIGR에 의해 서열화되지 않음).

[표 2a]

표 2b: 세균성 표면 및 리보솜 전시에 의해 확인된 추가 면역원성 단백질: 스타필로코커스 아우레우스( S. aureus )

세균성 표면 전시: 환자 혈청 1(655)의 fhuA 내에 A, LSA250/1 라이브러리; B, lamB 내에 LSA50/6 라이브러리, 환자 혈청 1(484); C, fhuA 내에 LSA250/1 라이브러리, IC 혈청 1(571); E, lamB 내에 LSA50/6 라이브러리, IC 혈청 2(454); F, lamB 내에 LSA50/6 라이브러리, 환자 혈청 P1(1105); G, lamB 내에 LSA50/6 라이브러리, IC 혈청 1(471); H, fhuA 내에 LSA250/1 라이브러리, 환자 혈청 1(IgA, 708); 리보솜 전시: D, LSA250/1 라이브러리, IC 혈청(1686). **, 5개 이상 아미노산보다 더 긴 항원 서열 예측은 프로그램 ANTIGENIC(Kolaskar and Tongaonkar, 1990)을 이용하여 실행하였다. ORF: 개방 해독틀; CRF, 상보서열의 해독틀; ARF, 또 다른 방식으로 판독되는 프레임.

[표 2b]

표 2c: 세균성 표면 및 리보솜 전시에 의해 확인된 면역원성 단백질: 스타필 로코커스 에피데르미디스( S. epidermidis )

세균성 표면 전시: 환자 혈청 1(957)의 fhuA 내에 A, LSE150 라이브러리; B, lamB 내에 LSE70 라이브러리, 환자 혈청 2(1420); C, lamB 내에 LSE70 라이브러리, 환자 혈청 1(551); 리보솜 전시: D, pMAL4.31과 P2(1235)에 LSE150. **, 5개 이상 아미노산보다 더 긴 항원 서열 예측은 프로그램 ANTIGENIC(Kolaskar and Tongaonkar, 1990)을 이용하여 실행하였다. ORF: 개방 해독틀; CRF, 상보서열의 해독틀; ARF, 또 다른 방식으로 판독되는 프레임; ORF: 개방 해독틀; CRF 상보 가닥상의 해독틀.

[표 2c]

표 2d: 세균성 표면 및 리보솜 전시에 의해 확인된 면역원성 단백질: 스타필 로코커스 아우레우스( S. aureus )( 새로운 주석 )

세균성 표면 전시: 환자 혈청 1(655)의 fhuA 내에 A, LSA250/1 라이브러리; B, lamB 내에 LSA50/6 라이브러리, 환자 혈청 1(484); C, fhuA 내에 LSA250/1 라이브러리, IC 혈청 1(571); E, lamB 내에 LSA50/6 라이브러리, IC 혈청 2(454); F, lamB 내에 LSA50/6 라이브러리, 환자 혈청 P1(1105); G, lamB 내에 LSA50/6 라이브러리, IC 혈청 1(471); 리보솜 전시: D, LSA250/1 라이브러리, IC 혈청(1686). **, 5개 이상 아미노산보다 더 긴 항원 서열 예측은 프로그램 ANTIGENIC(Kolaskar and Tongaonkar, 1990)을 이용하여 실행하였다. #, ORF에서 2개씩 존재하는 동일한 서열.

[표 2d]

[표 3a]

인간 혈청을 이용한 스타필로코커스 아우레우스( S. aureus ) 표면 단백질의 혈청학적 프로테옴 분석

a) 스타필로코커스 아우레우스( S. aureus )/agr “스트레스 조건”

[표 3b]

스타필로코커스 아우레우스( S. aureus )/COL “표준 조건”

[표 3c]

스타필로코커스 아우레우스( S. aureus )/COL “스트레스 조건”

[표 4]

MALDI-TOF-MS 서열화에 의해 확인된 스타필로코커스 아우레우스( S. aureus ) 항원(굵게 표시된 ORF는 세균성 표면 전시에 의해 확인되었다). 인간 혈청을 이용한 혈청학적 프로테옴 분석에 의해 확인된 선별된 항원에서 항원성 부분 예측.

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cctatgacagccaaaatggatacaactattacgccatttcagattattcattcgaaaaat gatcatccagaaggaacgattgcgacggtatctaatgtgaataaactgacgaaacctttg aaaaataaagaagtgaagtccgtggaacatgttcgtcgtgatcataacttgatgattcct gatttgaacagtgattttatattattcgattttacgtatgatttaccgttatcaacatat cttggtcaagtactgaacatgaatgcgaaagtaccaaatcatttcaatttcaatcgtttg gtcatagatcatgatgctgatgataatatcgtgctttatgctataagcaaagatcgccac gattacgtaaaattaacaactacaacgaaaaatgatcattttttagatgcattagcagca gtgaaaaaagatatgcaaccatacacagata tcatcacaaacaaagatacaattgatcgt acgacgcatgtttttgcaccaagtaaacctgaaaagttaaaaacatatcgcatggtattt aacacgattagtgttgagaaaatgaatgctatactatttgacgattcaaccatcgttcgt agttcaaagagtggtgttacaacctacaacaataatacaggtgtcgcaaactataacgat aaaaatgaaaaatatcattataaaaacctgtccgaagatgaagcgagttccagcaaaatg gaagaaacgattccaggaacctttgattttattaatggtcatggtggtttcttaaacgaa gactttagattgtttagtacgaataatcagtcaggcgagttaacatatcaacgtttcctt aatggttatccaacgtttaataaagaaggttctaatcaaattcaagtcacttggggtgaa aaaggcgtctttgactatcgtcgttcgttattacgcaccgacgttgttttaaatagtgag gataataaatcgttgccgaaattagagtctgtacgttcaagcttagcgaacaatagtgat attaattttgaaaaagtaacaaacatcgctatcggttacgaaatgcaggataattcagat cataatcacattgaagtgcagattaacagtgaactcgtaccgcgttggtatgtagaatat gatggcgaatggtatgtttataacgatgggaggcttgaa 8. atgagtaaaagacagaaagcatttcatgacagcttagcaaacgaaaaaacaagagtaaga ctttataaatctggaaaaaattgggtaaaatccggaattaaagaaatagaaatgttcaaa attatggggctaccatttattagtcatagtttagtgagtcaagataatcaaagcattagt aaaaaaatgacgggatacggactgaaaactacggcggttattggtggtgcattcacggta aatatgttgcat gaccagcaagcttttgcggcttctgatgcaccattaacttctgaatta aacacacaaagtgaaacagtaggtaatcaaaactcaacgacaatcgaagcatcaacatca acagccgattccacaagtgtaacgaaaaatagtagttcggtacaaacatcaaatagtgac acagtctcaagtgaaaagtctgaaaaggtcacttcgacaactaatagtacaagcaatcaa caagagaaattgacatctacatcagaatcaacatcctcaaagaatactacatcaagttct gatactaaatctgtagcttcaacttcaagtacagaacaaccaattaatacatcaacaaat caaagtactgcatcaaataacacttcacaaagcacaacgccatcttcggtcaacttaaac aaaactagcacaacgtcaactagcaccgcaccagtaaaacttcgaactttcagtcgctta gctatgtcaacatttgcgtcagcagcgacgacaaccgcagtaactgctaatacaattaca gttaataaagataacttaaaacaatatatgacaacgtcaggtaatgctacctatgatcaa agtaccggtattgtgacgttaacacaggatgcatacagccaaaaaggtgctattacatta ggaacacgtattgactctaataagagttttcatttttctggaaaagtaaatttaggtaac aaatatgaagggcatggaaatggtggagatggtatcggttttgccttttcaccaggtgta ttaggtgaaacagggttaaacggtgccgcagtaggtattggtggcttaagtaacgcattt ggcttcaaattggatacgtatcacaatacatctaaaccaaattcagctgcaaaggcgaat gctgacccatctaatgtagctggtggaggtgcgtttggtgcatttgtaacaacagatagt tatggtgttgcgacaacgtatacatcaagttcaaca gctgataatgctgcgaagttaaat gttcaacctacaaataacacgttccaagattttgatattaactataatggtgatacaaag gttatgactgtcaaatatgcaggtcaaacatggacacgtaatatttcagattggattgcg aaaagtggtacgaccaacttttcattatcaatgacagcctcaacaggtggcgcgacaaat ttacaacaagtacaatttggaacattcgaatatacagagtctgctgttacacaagtgaga tacgttgatgtaacaacaggtaaagatattattccaccaaaaacatattcaggaaatgtt gatcaagtcgtgacaatcgataatcagcaatctgcattgactgctaaaggatataactac acgtccgtcgatagttcatatgcgtcaacttataatgatacaaataaaactgtaaaaatg acgaatgctggacaatcagtgacatattattttactgatgtaaaagcaccaactgtaact gtaggcaatcaaaccatagaagtgggtaaaacaatgaatcctattgtattgactacaacg gataatggtactgggactgtgacaaatacagttacaggattaccaagcggattaagttac gatagtgcaacgaattcaatcattgggacaccaacaaaaattggtcaatcaacagtgaca gttgtgtctactgaccaagcaaataacaaatcgacgacaacttttacaataaatgttgtg gatacgacagcaccaacagtgacaccaataggagatcaatcatcagaagtgtattcacca atatccccgattaaaattgctacgcaagataacagtggaaatgcggtgacgaatacagtg actggattgccatccggactaacatttgatagtacaaataatactattagtggtacacca acaaacattggtacaagtactatatcaatcgtttctacagatgcgagcggtaacaaaacg acgacaacttttaaatatgaagtaacaagaaatagcatgagtgattccgtatcaacatca ggaagtacacaacaatctcaaagtgtgtcaacaagtaaagctgactcacaaagtgcatca acgagtacatcaggatcgattgtggtatctacatcagctagtacctcgaaatcgacaagt gtaagcctatctgattctgtgagtgcatctaagtcattaagcacatctgaaagtaatagt gtatcaagctcaacaagcacaagtttagtgaattcacaaagtgtatcatcaagcatgtcg gattcagctagtaaatcaacatcattaagcgattctatttcaaactctagcagtactgaa aaatccgaaagtctatcaacaagtacatctgattcattgcgtacatcaacatcactcagt gactcattaagtatgagtacatcaggaagcttgtctaagtcacaaagcttatcaacgagt atatcagggtcgtctagtacatcagcatcattaagtgacagtacatcgaatgcaattagt acatcaacatcattgagcgagtcagctagcacctcggactctatcagtatttcaaatagc atagccaactctcaaagtgcgtcaacaagcaaatcagattcacaaagtacatcaatatca ttaagtacaagtgattcaaaatcgatgagtacatcagaatcattgagcgattcgacgagc acaagtggttctgtttctggatcactaagcatagcagcatcacaaagtgtctcaacaagt acatcagactcgatgagtacttcagagatagtaagtgactctatcagtacaagtgggtca ttatctgcatcagacagtaaatcaatgtccgtaagtagttcaatgagcacgtctcagtca ggtagtacatcagaatcattaagtgattcacaaagtacatctgattctgatagtaagtca ttatcacaaagtactagtcaatc aggttcaacaagtacatcaacgtcgacaagtgcttca gtacgtacttcggaatcacaaagtacgtctggttcaatgagtgcaagtcaatccgattca atgagcatatcaacgtcgtttagtgattcaacgagtgatagcaaatcagcatcaactgca tcaagtgaatcaatatcacaaagtgcttctacgagcacatctggttcggtaagtacttcg acatcgttaagtacaagtaattcagaacgtacatcaacatctatgagtgattccacaagc ttaagtacatcagagtctgattcaataagtgaatcaacgtcaacgagcgactctataagt gaagcaatatctgcttcagagagcacgtttatatcattaagtgaatcaaatagtactagc gattcagaatcacaaagtgcatctgcctttttaagtgaatcattaagtgaaagtacgtct gaatcaacatcagagtcagtgagtagttcgacaagtgagagtacgtcattatcagacagt acatcagaatctggtagcacatcaacatcattaagtaattcaacaagtggtagtacgtcc atttcaacatcgacaagtatcagtgaatcaacgtcaacgtttaagagcgagagtgtttca acatcactgagtatgtcaacgagtacaagtttgtctgactctacaagtttgtcaacatca ttaagtgattccacaagtgatagtaagtctgattcattaagtacatcaatgtcgacaagt gattcaatcagtacaagtaaatctgattccattagtacatccacatcattaagtggttct acaagtgaaagtaaatccgattcaacatcaatgagcataagtatgtctcaatcaacatca ggaagtacaagtacgtcaacgagtacaagtttgtctgactcaacgagtacatcattgtca ctaagtgcctcaatgaatcaaagcggagtagactcaaactcagcaag ccaaagtgcctca aactcaacaagtacaagcacgagcgaatccgattcacaaagcacatcatcatatacaagt cagtcaacaagccaaagtgaatccacatcgacatcaacgtcactaagcgattcaacaagt atatctaaaagtacgagtcaatcaggttcggtaagcacatcagcgtcattaagtggttca gagagtgaatctgattcacaaagtatctcaacaagtgcaagtgagtcaacatcagaaagt gcgtcaacatcactcagtgactcaacaagtacaagtaactcaggatcagcaagtacgtca acatcgctcagtaactcagcaagcgcaagtgaatccgatttgtcgtcaacatctttaagt gattcaacatctgcgtcaatgcaaagcagtgaatccgattcacaaagcacatcagcatca ttaagtgattcgctaagtacatcaacttcaaaccgcatgtcgaccattgcaagtttatct acatcggtaagtacatcagagtctggctcaacatcagaaagtacaagtgaatccgattca acatcaacatcattaagcgattcacaaagcacatcaagaagtacaagtgcatcaggatca gcaagtacatcaacatcaacaagtgactctcgtagtacatcagcttcaactagtacttcg atgcgtacaagtactagtgattcacaaagtatgtcgctttcgacaagtacatcaacaagt atgagtgattcaacgtcattatctgatagtgttagtgattcaacatcagactcaacaagt gcgagtacatctggttcgatgagtgtgtctatatcgttaagtgattcgacaagtacatca acatcggctagtgaagtaatgagcgcaagcatatctgattcacaaagtatgtcagaatct gtaaatgattcagaaagtgtaagtgaatctaattctgaaagtgactctaaatcgatgagt ggctcaacaa gtgtcagtgattctggctcattgagcgtctcaacgtcattaagaaaatca gaaagtgtaagcgagtcaagttcattgagttgctcacaatcgatgagcgattcagtaagc acaagcgattcgtcatcattaagtgtatcgacgtcactaagaagttcagaaagcgtgagt gaatctgattcattaagtgattcaaaatcaacaagtggttcgacttcaacaagtacatct ggttcattgagtacctcaacatcattaagtggttcagaaagcgtaagcgagtctacctcg ctaagtgattcaatatcaatgagtgattctactagtacaagtgactccgactcattaagt ggatcaatatctttaagtggttccacaagtcttagcacttcggattcattaagtgattca aaatcattgagtagctcgcaaagtatgagtggatcagaatcaacgtcaacaagtgtgagc gattcgcagtcaagctcaacaagtaatagtcaatttgactctatgagcatcagtgcatca gaaagcgactcaatgtctacaagtgattcgtctagcatcagtggatcaaattcaacgagt acatcactttcaacatctgactcaatgagcggaagcgtatcagtttcaacatcgacaagt ttaagtgactcaatatcaggttcaacaagtgtaagtgactcgagctcaacaagcacatct acatcattaagtgattcaatgtcacaaagccagtcaacaagtacaagtgcatctggttcc ttaagtacatcgatatcaacatcaatgtcaatgagtgctagtacatcgtcatcacaaagc acatcggtgtcgacatcattatcaacatcagacagtatcagtgattctacttcaataagt atcagtggttcacaaagtacagtagaatcagaatctacaagtgattcaacttctatcagt gactcagaatcattgagtacatcagattcagact cgacatcgacaagtacatcggactca acaagtggttcaacttcaacaagcatatctgaatcattaagtacgtctggttcaggttca acgagcgtatctgactcaacatcaatgagtgaatctaattcatcgagtgtttcaatgtca caagacaaatccgactcaacatcaattagtgactcagaatcagtgtcaacaagcacatca acgtcattgagcacatccgattcgacaagcacatccgaatcactgagtacatctatgtct ggttcacaaagcatttctgactcaacatcaacaagtatgtccggctcaacaagtacatct gaatctaactcaatgcatccgtcagactcaatgagtatgcatcatactcacagcacgagc acatctcgcttatcaagtgaagcaacaacgagcacgagtgaatctcagtctacattaagt gcaacatctgaagtgactaaacataatggcacaccagcacaaagtgaaaaaagattgcca gatacaggtgactcaataaaacaaaatggattactaggtggcgttatgacattattagtt ggtttaggtttaatgaagagaaagaaaaagaaagatgaaaatgatcaagatgattctcaa gca 9. atgcctaaaaataaaattttaatttatttgctatcaactacgctcgtattacctacttta gtttcacctaccgcttatgctgatacacctcaaaaagatactacagctaagacaacatct catgattcaaaaaaatctaatgacgatgaaacttctaaggatactacaagtaaagatatt gataaagcagacaaaaataatacaagtaaccaagacaataacgacaaaaaatttaaaact atagacgacagcacttcagactctaacaatatcattgattttatttataagaatttacca caaaccaatataaaccaattgctaaccaaaaataaatacgatgataattac tcattaaca actttaatccaaaacttattcaatttaaattcggatatttctgattacgaacaacctcgt aatggcgaaaagtcaacaaatgattcgaataaaaacagtgacaatagcatcaaaaatgac actgatacgcaatcatctaaacaagataaagcagacaatcaaaaagcacctaaatcaaac aatacaaaaccaagtacatctaataagcaaccaaattcgccaaagccaacacaacctaat caatcaaatagtcaaccagcaagtgacgataaagcaaatcaaaaatcttcatcgaaagat aatcaatcaatgtcagattcggctttagactctattttggatcaatacagtgaagatgca aagaaaacacaaaaagattatgcatctcaatctaaaaaagacaaaaatgaaaaatctaat acaaagaatccacagttaccaacacaagatgaattgaaacataaatctaaacctgctcaa tcattcaataacgatgttaatcaaaaggatacacgtgcaacatcattattcgaaacagat cctagtatatctaacaatgatgatagcggacaatttaacgttgttgactcaaaagataca cgtcaatttgtcaaatcaattgctaaagatgcacatcgcattggtcaagataacgatatt tatgcgtctgtcatgattgcccaagcaatcttagaatctgactcaggtcgtagtgcttta gctaagtcaccaaaccataatttattcggtatcaaaggtgcttttgaagggaattctgtt ccttttaacacattagaagctgatggtaatcaattgtatagtattaatgctggattccga aaatatccaagcacgaaagaatcactaaaagattactctgaccttattaaaaatggtatt gatggcaatcgaacaatttataaaccaacatggaaatcggaagccgattcttataaagat gcaacatcacactt atctaaaacatatgctacagatccaaactatgctaagaaattaaac agtattattaaacactatcaattaactcagtttgacgatgaacgcatgccagatttagat aaatatgaacgttctatcaaggattatgatgattcatcagatgaattcaaacctttccgt gaggtatctgatagtatgccatatccacatggccaatgtacttggtacgtatataaccgt atgaaacaatttggtacatctatctcaggtgatttaggtgatgcacataattggaataat cgagctcaataccgtgattatcaagtaagtcatacaccaaaacgtcatgctgctgttgta tttgaggctggacaatttggtgcagatcaacattacggtcatgtagcatttgttgaaaaa gttaacagtgatggttctatcgttatttcagaatccaatgttaaaggattaggtatcatt tctcatagaactatcaacgcagctgccgctgaagaattatcatatattacaggtaaa 10. gtgaggaaattttcaagatatgcatttacaagtatggcagcattaaccttgttgagcact ttatcaccagcagcattagcgattgattcaaaaaataaaccagctaattctgatattaaa tttgaggtgactcaaaagagtgatgcggtcaaagcattaaaagaattgcctaaatccgaa aatgtaaaaaatatttatcaagattacgctgttactgatgtaaaaactgataaaaaagga tttacgcattatacattgcaaccgagtgttgatggtgttcatgcacctgacaaagaagtg aaagtacacgcagacaaatcaggaaaagtcgttttaatcaatggggatactgatgcgaag aaagtaaagccaacgaataaagtgacattaagtaaagatgacgcagccgacaaagcattt aaagcagttaagattgataagaataaagcgaaaaatc ttaaagataaagtcattaaagaa aacaaagttgaaatcgatggtgacagtaataaatacgtttataatgttgagttaattaca gtgacaccagaaatttcacattggaaagttaaaattgatgctcaaactggcgaaatttta gaaaaaatgaacttagttaaagaagctgcagaaactggtaaaggaaaaggtgtacttggc gatacaaaagatatcaatatcaatagtattgacggtggatttagcctagaagatttaacg catcaaggtaaattatcagcatttagctttaatgatcaaacaggtcaagcaacattgatt actaatgaagatgaaaacttcgtaaaagatgagcaacgtgctggcgtagatgcaaattat tacgctaaacaaacatatgattattacaaagacacatttggtcgtgaatcatatgacaac caaggtagtccaattgtttcattaacgcatgttaataactacggtggtcaagataacaga aataatgccgcatggatcggtgacaaaatgatctatggtgatggtgatggtcgcacattc acaagtttatcgggtgcaaatgacgtagtagcacacgaattaacacacggtgtgacacaa gagacagcgaacttagaatataaggaccagtcaggcgctctaaatgaaagcttttcagat gtttttggatactttgtagatgacgaggatttcttaatgggtgaagatgtctacacacct ggaaaagagggagacgctttacgcagcatgtcaaacccagaacaatttggtcaaccagct catatgaaagactatgtattcactgaaaaagataatggtggcgtacatacgaattctgga attccaaataaagcagcttataacgtgattcaagcaatagggaaatctaaatcagaacaa atttactaccgagcattaacggaatacttaacaagtaattcaaacttcaaagattgtaaa gatgcattataccaagcggctaaagatttatatgacgagcaaacagctgaacaggtgtat gaagcatggaatgaagtaggcgtggag 11. ttgaaaaaaagaattgattatttgtcgaataagcagaataagtattcgattagacgtttt acagtaggtaccacatcagtaatagtaggggcaactatactatttgggataggcaatcat caagcacaagcttcagaacaatcgaacgatacaacgcaatcttcgaaaaataatgcaagt gcagattccgaaaaaaacaatatgatagaaacacctcaattaaatacaacggctaatgat acatctgatattagtgcaaacacaaacagtgcgaatgtagatagcacaacaaaaccaatg tctacacaaacgagcaataccactacaacagagccagcttcaacaaatgaaacacctcaa ccgacggcaattaaaaatcaagcaactgctgcaaaaatgcaagatcaaactgttcctcaa gaagcaaattctcaagtagataataaaacaacgaatgatgctaatagcatagcaacaaac agtgagcttaaaaattctcaaacattagatttaccacaatcatcaccacaaacgatttcc aatgcgcaaggaactagtaaaccaagtgttagaacgagagctgtacgtagtttagctgtt gctgaaccggtagtaaatgctgctgatgctaaaggtacaaatgtaaatgataaagttacg gcaagtaatttcaagttagaaaagactacatttgaccctaatcaaagtggtaacacattt atggcggcaaattttacagtgacagataaagtgaaatcaggggattattttacagcgaag ttaccagatagtttaactggtaatggagacgtggattattctaattcaaataatacgatg ccaattgcagacattaaaagtacgaatggcgatgttgtagctaaagcaacata tgatatc ttgactaagacgtatacatttgtctttacagattatgtaaataataaagaaaatattaac ggacaattttcattacctttatttacagaccgagcaaaggcacctaaatcaggaacatat gatgcgaatattaatattgcggatgaaatgtttaataataaaattacttataactatagt tcgccaattgcaggaattgataaaccaaatggcgcgaacatttcttctcaaattattggt gtagatacagcttcaggtcaaaacacatacaagcaaacagtatttgttaaccctaagcaa cgagttttaggtaatacgtgggtgtatattaaaggctaccaagataaaatcgaagaaagt agcggtaaagtaagtgctacagatacaaaactgagaatttttgaagtgaatgatacatct aaattatcagatagctactatgcagatccaaatgactctaaccttaaagaagtaacagac caatttaaaaatagaatctattatgagcatccaaatgtagctagtattaaatttggtgat attactaaaacatatgtagtattagtagaagggcattacgacaatacaggtaagaactta aaaactcaggttattcaagaaaatgttgatcctgtaacaaatagagactacagtattttc ggttggaataatgagaatgttgtacgttatggtggtggaagtgctgatggtgattcagca gtaaatccgaaagacccaactccagggccgccggttgacccagaaccaagtccagaccca gaaccagaaccaacgccagatccagaaccaagtccagacccagaaccggaaccaagccca gacccggatccggattcggattcagacagtgactcaggctcagacagcgactcaggttca gatagcgactcagaatcagatagcgattcggattcagacagtgattcagattcagacagc gactcagaatcagata gcgattcagaatcagatagcgactcagattcagatagcgattca gattcagatagcgattcagattcagatagcgattcggattcagacagtgattcagattca gacagcgactcagaatcagatagcgactcagaatcagatagtgagtcagattcagacagt gactcggactcagacagtgattcagactcagatagcgattcagactcagatagcgattca gattcagacagcgactcagattcagacagcgactcagactcagatagcgactcagactca gacagcgactcagattcagatagcgattcagactcagacagcgactcagactcagacagc gactcagactcagatagcgactcagattcagatagcgattcagactcagacagcgactca gattcagatagcgattcggactcagacagcgattcagattcagacagcgactcagactcg gatagcgattcagattcagatagcgattcggattcagacagtgattcagattcagacagc gactcagactcggatagcgactcagactcagacagcgattcagactcagatagcgactca gactcggatagcgactcggattcagatagcgactcagactcagatagtgactccgattca agagttacaccaccaaataatgaacagaaagcaccatcaaatcctaaaggtgaagtaaac cattctaataaggtatcaaaacaacacaaaactgatgctttaccagaaacaggagataag agcgaaaacacaaatgcaactttatttggtgcaatgatggcattattaggatcattacta ttgtttagaaaacgcaagcaagatcataaagaaaaagcg 12. atgaaaaagacaattatggcatcatcattagcagtggcattaggtgtaacaggttacgca gcaggtacaggacatcaagcacacgctgctgaagtaaacgttgatcaagcacactta gtt gacttagcgcataatcaccaagatcaattaaatgcagctccaatcaaagatggtgcatat gacatccactttgtaaaagatggtttccaatataacttcacttcaaatggtactacatgg tcatggagctatgaagcagctaatggtcaaactgctggtttctcaaacgttgcaggtgca gactacactacttcatacaaccaaggttcaaatgtacaatcagtaagctacaatgcacaa tcaagtaactcaaacgttgaagctgtttcagctccaacttaccataactacagcacttca actacttcaagttcagtgagattaagcaatggtaatactgcaggtgctactggttcatca gcagctcaaatcatggctcaacgtactggtgtttcagcttctacatgggctgcaatcatc gctcgtgaatcaaatggtcaagtaaatgcttacaacccatcaggtgcttcaggtttattc caaactatgccaggttggggtccaacaaacactgttgaccaacaaatcaacgcagctgtt aaagcatacaaagcacaaggtttaggtgcttggggattc 13. ttgggaggatatttaattatgaaaaaaatcgttacagctacaatcgctacagcaggactt gccactatcgcatttgcaggacatgatgcacaagccgcagaacaaaataacaatggatat aattctaatgacgctcaatcatacagctatacgtatacaattgatgcacaaggtaattat cattacacttggacaggaaattggaatccaagtcaattaacgcaaaacaacacatactac tacaacaactacaatacttatagttataacaatgcatcttacaataactactataatcat tcatatcaatacaataactatacaaacaatagtcaaacagcaacaaataactattatact ggtggttcaggtgcaagttatagcacaacaagtaata atgttcatgtgactacaactgca gcgccatcttcaaatggtcgttcaatttctaatggttatgcatcaggaagtaacttatat acttcaggacaatgtacttattatgtatttgatcgtgttggtgggaaaattggttcaaca tggggtaacgcaagtaattgggctaacgcagctgcatcatctggctatacagtgaacaat acaccaaaagttggtgctatcatgcaaacaacacaaggctattacggtcatgttgcttac gttgaaggcgttaacagcaacggttctgttcgtgtttcagaaatgaactatggacatggt gctggtgtggttacgtctcgtacaatttcagcaaaccaagcaggttcatataatttcatt cat 14. gtggctaatacgaaaaaaacaacattagatatcactggtatgacttgtgccgcatgttca aatcgtatcgaaaagaaactgaataaacttgatgacgttaatgcccaagtgaatttaact acagagaaagcaactgttgagtataaccctgatcaacatgatgtccaagaatttattaat acgattcaacatttaggttacggtgtcgctgtagaaactgtcgaattagacattacaggt atgacttgtgctgcatgctcaagccgtattgaaaaagtgttaaataaaatggacggcgtt caaaatgcaacggtcaatttaacaacagagcaagctaaagttgactattatcctgaagaa acagatgctgataaacttgtcactcgcattcaaaaattaggttatgacgcgtctattaaa gataacaataaagatcaaacgtcacgcaaagctgaagcgctacaacataaattgattaag cttatcatatcagcagtattatctttaccactattaatgttaatgtttgtacatcttttc aatatgcatataccagcactatttacgaatccatggttccaatttattttagc tacacct gtacaatttattattggatggcaattttatgtaggtgcttataaaaacttaagaaatggt ggcgccaatatggatgtacttgttgctgttggtacaagtgcagcatatttttacagtatt tatgaaatggttcgttggctaaatggctcaacaacgcaaccgcatttatactttgaaaca agcgccgtactaattaccttaatcttattcggtaagtatttagaagctagagcgaagtct caaacaaccaatgcgcttggcgaattattaagtttacaagctaaagaagcacgcatttta aaagatggtaatgaagtgatgattcctctaaatgaagtacatgttggagatacacttatc gttaaaccaggtgaaaagatacctgttgatggcaaaattattaaaggtatgactgccatc gacgaatctatgttaacaggtgaatctatccctgttgagaagaatgttgatgatactgta attggttcaacgatgaacaaaaacggtactattactatgacagcaacaaaagttggcggg gacaccgcgttggcaaatattattaaagttgtcgaagaagctcaaagttctaaagcgccg attcaacgattggcagatattatttctggttatttcgttcctatcgttgttggtatcgca ctattaacatttatcgtgtggattactttagttacaccaggtacatttgaacctgcactt gttgcgagtatttccgttctcgtcattgcttgtccatgcgcattgggacttgctacacca acttctattatggtaggtactggtcgcgctgctgaaaatggtattttatttaaaggtggc gagtttgttgaacgcacacatcaaattgataccatcgttttagataagacgggtaccatt acaaatggtcgtccagtcgtgacagattatcatggtgacaatcaaacgctacaactactt gctactgctgaaaaag attctgaacacccattggcagaagccattgtcaattatgcaaaa gaaaagcaattaatattaactgagacaacaacatttaaagcagtacctggccatggtatt gaagcaacgattgatcatcaccatatattggttggtaaccgtaaattaatggctgacaat gatattagcttgcctaagcatatttctgatgatttaacacattatgaacgagatggtaaa actgctatgctcattgctgttaattattcattaactggtatcatcgcagtggcagatact gtcaaagatcatgccaaagatgctataaaacaattgcatgatatgggcattgaagttgcc atgttaactggcgataataaaaacactgctcaagccattgcaaaacaagtaggcatagat actgttattgcagatattttaccagaagaaaaagctgcacaaattgcgaaactacagcaa caaggtaagaaggttgcgatggttggtgacggtgtaaatgatgcacctgcattagttaaa gctgatatcggtatcgccattggtacaggtacagaagttgccattgaagcagctgatatt actattcttggtggcgacttgatgcttattcctaaagccatttatgcaagtaaagcaacc attcgtaatattcgtcaaaatctattttgggcattcggctataatattgccggtatccct atagctgcattgggcttacttgcgccatgggttgctggtgctgcaatggcactaagttca gtaagtgttgtcacaaacgcacttagattgaaaaagatgcgattagaaccacgccgtaaa gatgcc 15. atgtttgattcaattagagagactatagattatgccgtagaaaataatatgtcatttgcg gatatcatggttaaagaagaaatggaattaagcggtaaatcacgtgatgaagtgcgagcg caaatgaaacaaaatttagatgtcatgcg agacgcagtaatcaaagggacgacaggtgat ggggttgaaagtgtaacgggctacactggtcatgatgctgctaaactacgtgattataat gaaacacatcatgctttgtctggatatgaaatgattgacgcagtcaaaggtgccattgca acaaatgaagtcaatgctgcgatgggtattatttgtgcaacgccaacagctggttcctcg ggtaccattcccggtgcactttttaaattagaaaaaacacatgatttaacagaagagcaa atgattgatttcttattcacttcagcattgtttgggcgtgtcgtagcaaacaatgcaagt gtagctggtgcaacaggtggctgccaagctgaagttggttcagcatctgcaatggccgca gctgcagcagtagctatattcggaggatcaccagaagcatccgggcacgctatggcatta gcgataagtaatttattaggtttagtttgtgatccagtagccggacttgttgaaattcct tgtgttatgagaaatgcaattggttcgggtaacgctttaatttcagcagatttagcatta gcaggtattgaaagtagaatccctgttgatgaagttattgaagcaatggataaggttggt cgtaaccttcctgcatcattacgtgaaactggattgggtggactagcaggcacaccaact ggcgaagcaattaaacgtaaaatctttggcacagctgaagatatggttaaaaataat 16. gtgaaaaacaatcttaggtacggcattagaaaacataaattgggagcagcatcagtattc ttaggaacaatgatcgttgttgggatgggacaagacaaagaagctgcagcatcagaacaa aagacaactacagtagaagaaaatgggaattcagctactgataataaaacaagtgaaaca caaacaactgcaactaacgttaatcatatagaagaaactcaatcatataacg caacagta acagaacaaccgtcaaacgcaacacaagtaacaactgaagaagcaccaaaagcagtacaa gcaccacaaactgcacaaccagcaaatatagaaacagttaaagaagaggtagttaaggaa gaagcgaaacctcaagttaaggaaacaacacaatctcaagacaatagcggagatcaaaga caagtagatttaacacctaaaaaggctacacaaaatcaagtcgcagaaacacaagttgaa gtggcacagccaagaacggcatcagaaagtaagccacgtgtgacaagatcagcagatgta gcggaagctaaggaagctagtaacgcgaaagtggaaacgggtacagatgtaacaagtaaa gttacagtagaaattggttctattgaggggcataacaatacaaataaagtagaacctcat gcaggacaacgagcggtactaaaatataagttgaaatttgagaatggtttacatcaaggt gactactttgactttactttatcaaataatgtaaatacgcatggcgtatcaactgctaga aaagtaccagaaattaaaaatggttcagtcgtaatggcgacaggtgaagttttagaaggt ggaaagattagatatacatttacaaatgatattgaagataaggttgatgtaacggctgaa ctagaaattaatttatttattgatcctaaaactgtacaaactaatggaaatcaaactata acttcaacactaaatgaagaacaaacttcaaaggaattagatgttaaatataaagatggt attgggaattattatgccaatttaaatggatcgattgagacatttaataaagcgaataat agattttcgcatgttgcatttattaaacctaataatggtaaaacgacaagtgtgactgtt actggaactttaatgaaaggtagtaatcagaatggaaatcaaccaaaagttaggatattt gaatacttgggtaat aatgaagacatagcgaagagtgtatatgcaaatacgacagatact tctaaatttaaagaagtcacaagtaatatgagtgggaatttgaatttacaaaataatgga agctattcattgaatatagaaaatctagataaaacttatgttgttcactatgatggagag tatttaaatggtactgatgaagttgattttagaacacaaatggtaggacatccagagcaa ctttataagtattattatgatagaggatataccttaacttgggataatggtttagtttta tacagtaataaagcgaacggaaatgggaaaaatggtccgattattcaaaataataaattt gaatataaagaagatacaattaaagaaactcttacaggtcaatatgataagaatttagta actactgttgaagaggaatatgattcatcaactcttgacattgattaccacacagctata gatggtggaggtggatatgttgatggatacattgaaacaatagaagaaacggattcatca gctattgatatcgattaccatactgctgtggatagcgaagcaggtcacgttggaggatac actgagtcctctgaggaatcaaatccaattgactttgaagaatctacacatgaaaattca aaacatcacgctgatgttgttgaatatgaagaagatacaaacccaggtggtggtcaggtt actactgagtctaacttagttgaatttgacgaagagtctacaaaaggtattgtaactggc gcagtgagcgatcatacaacagttgaagatacgaaagaatatacaactgaaagtaatctg attgaattagtggatgaattacctgaagagcatggtcaagcacaaggaccagtcgaggaa attactgaaaacaatcatcatatttctcattctggtttaggaactgaaaatggtcacggg aattatgacgtgattgaagaaatcgaagaaaatagccac gttgatattaagagtgaatta ggttatgaaggtggccaaaatagcggtaaccagtcattcgaggaagacacagaagaagac aaacctaaatatgaacaaggtggcaatatcgtagatatcgattttgatagtgtacctcaa attcatggtcaaaataaaggtaatcagtcattcgaggaagatacagaaaaagacaaacct aagtatgaacatggcggtaacatcattgatatcgacttcgacagtgtgccacatattcac ggattcaataagcacactgaaattattgaagaagatacaaataaagataaaccaagttat caattcggtggacacaatagtgttgactttgaagaagatacacttccaaaagtaagcggc caaaatgaaggtcaacaaacgattgaagaagatacaacacctccaatcgtgccaccaacg ccaccgacaccagaagtaccaagtgagccggaaacaccaacgccaccaacaccagaagta ccaagtgagccggaaacaccaacaccaccgacaccagaagtgccgagtgagccagaaact ccaacaccgccaacaccagaggtaccagctgaacctggtaaaccagtaccacctgccaaa gaagaacctaaaaagccttctaaaccagtggaacaaggtaaagtagtaacacctgttatt gaaatcaatgaaaaggttaaagcagtggcaccaactaaaaaaccacaatctaagaaatct gaactacctgaaacaggtggagaagaatcaacaaacaaaggtatgttgttcggcggatta ttcagcattctaggtttagcattattacgcagaaataaaaagaatcacaaagca 17. ttgcatttaagggagaatattatagtgaaaagcaatcttagatacggcataagaaaacac aaattgggagcggcctcagtattcttaggaacaatgatcgttgttggaatgggacaagaa aaag aagctgcagcatcggaacaaaacaatactacagtagaggaaagtgggagttcagct actgaaagtaaagcaagcgaaacacaaacaactacaaataacgttaatacaatagatgaa acacaatcatacagcgcgacatcaactgagcaaccatcacaatcaacacaagtaacaaca gaagaagcaccgaaaactgtgcaagcaccaaaagtagaaacttcgcgagttgatttgcca tcggaaaaagttgctgataaggaaactacaggaactcaagttgacatagctcaaccaagt aacgtctcagaaattaaaccaagaatgaaaagatcaactgacgttacagcagttgcagag aaagaagtagtggaagaaactaaagcgacaggtacagatgtaacaaataaagtggaagta gaagaaggtagtgaaattgtaggacataaacaagatacgaatgttgtaaatcctcataac gcagaaagagtaaccttgaaatataaatggaaatttggagaaggaattaaggcgggagat tattttgatttcacattaagcgataatgttgaaactcatggtatctcaacactgcgtaaa gttccggagataaaaagtacagatggtcaagttatggcgacaggagaaataattggagaa agaaaagttagatatacgtttaaagaatatgtacaagaaaagaaagatttaactgctgaa ttatctttaaatctatttattgatcctacaacagtgacgcaaaaaggtaaccaaaatgtt gaagttaaattgggtgagactacggttagcaaaatatttaatattcaatatttaggtgga gttagagataattggggagtaacagctaatggtcgaattgatactttaaataaagtagat gggaaatttagtcattttgcgtacatgaaacctaacaaccagtcgttaagctctgtgaca gtaactggtcaagtaactaaaggaaata aaccaggggttaataatccaacagttaaggta tataaacacattggttcagacgatttagctgaaagcgtatatgcaaagcttgatgatgtc agcaaatttgaagatgtgactgataatatgagtttagattttgatactaatggtggttat tctttaaactttaataatttagaccaaagtaaaaattatgtaataaaatatgaagggtat tatgattcaaatgctagcaacttagaatttcaaacacacctttttggatattataactat tattatacaagtaatttaacttggaaaaatggcgttgcattttactctaataacgctcaa ggcgacggcaaagataaactaaaggaacctattatagaacatagtactcctatcgaactt gaatttaaatcagagccgccagtggagaagcatgaattgactggtacaatcgaagaaagt aatgattctaagccaattgattttgaatatcatacagctgttgaaggtgcagaaggtcat gcagaaggtaccattgaaactgaagaagattctattcatgtagactttgaagaatcgaca catgaaaattcaaaacatcatgctgatgttgttgaatatgaagaagatacaaacccaggt ggtggtcaggttactactgagtctaacctagttgaatttgacgaagattctacaaaaggt attgtaactggtgctgttagcgatcatacaacaattgaagatacgaaagaatatacgact gaaagtaatctgattgaactagtagatgaactacctgaagaacatggtcaagcgcaagga ccaatcgaggaaattactgaaaacaatcatcatatttctcattctggtttaggaactgaa aatggtcacggtaattatggcgtgattgaagaaatcgaagaaaatagccacgtggatatt aagagtgaattaggttacgaaggtggccaaaatagcggtaatcagtcatttg aggaagac acagaagaagataaaccgaaatatgaacaaggtggcaatatcgtagatatcgatttcgat agtgtacctcaaattcatggtcaaaataatggtaaccaatcattcgaagaagatacagag aaagacaaacctaagtatgaacaaggtggtaatatcattgatatcgacttcgacagtgtg ccacatattcacggattcaataagcacactgaaattattgaagaagatacaaataaagat aaaccaaattatcaattcggtggacacaatagtgttgactttgaagaagatacacttcca caagtaagtggtcataatgaaggtcaacaaacgattgaagaagatacaacacctccaatc gtgccaccaacgccaccgacaccagaagtaccaagcgagccggaaacaccaacaccaccg acaccagaagtaccaagcgagccggaaacaccaacaccgccaacgccagaggtaccaact gaacctggtaaaccaataccacctgctaaagaagaacctaaaaaaccttctaaaccagtg gaacaaggtaaagtagtaacacctgttattgaaatcaatgaaaaggttaaagcagtggta ccaactaaaaaagcacaatctaagaaatctgaactacctgaaacaggtggagaagaatca acaaacaacggcatgttgttcggcggattatttagcattttaggtttagcgttattacgc agaaataaaaagaatcacaaagca 18. atgcaaatgagagataagaaaggaccggtaaataaaagagtagattttctatcaaataaa ttgaataaatattcaataagaaaatttacagttggaacagcatctattttaattggctca ctaatgtatttgggaactcaacaagaggcagaagcagctgaaaacaatattgagaatcca actacattaaaagataatgtccaatcaaaagaagtgaagattgaaga agtaacaaacaaa gacactgcaccacagggtgtagaagctaaatctgaagtaacttcaaacaaagacacaatc gaacatgaaccatcagtaaaagctgaagatatatcaaaaaaggaggatacaccaaaagaa gtagctgatgttgctgaagttcagccgaaatcgtcagtcactcataacgcagagacacct aaggttagaaaagctcgttctgttgatgaaggctcttttgatattacaagagattctaaa aatgtagttgaatctaccccaattacaattcaaggtaaagaacattttgaaggttacgga agtgttgatatacaaaaaaaaccaacagatttaggggtatcagaggtaaccaggtttaat gttggtaatgaaagtaatggtttgataggagctttacaattaaaaaataaaatagatttt agtaaggatttcaattttaaagttagagtggcaaataaccatcaatcaaataccacaggt gctgatggttgggggttcttatttagtaaaggaaatgcagaagaatatttaactaatggt ggaatccttggggataaaggtctggtaaattcaggcggatttaaaattgatactggatac atttatacaagttccatggacaaaactgaaaagcaagctggacaaggttatagaggatac ggagcttttgtgaaaaatgacagttctggtaattcacaaatggttggagaaaatattgat aaatcaaaaactaattttttaaactatgcggacaattcaactaatacatcagatggaaag tttcatgggcaacgtttaaatgatgtcatcttaacttatgttgcttcaactggtaaaatg agagcagaatatgctggtaaaacttgggagacttcaataacagatttaggtttatctaaa aatcaggcatataatttcttaattacatctagtcaaagatggggccttaatcaagggata aatgcaaatg gctggatgagaactgacttgaaaggttcagagtttacttttacaccagaa gcgccaaaaacaataacagaattagaaaaaaaagttgaagagattccattcaagaaagaa cgtaaatttaatccggatttagcaccagggacagaaaaagtaacaagagaaggacaaaaa ggtgagaagacaataacgacaccaacactaaaaaatccattaactggagtaattattagt aaaggtgaaccaaaagaagagattacaaaagatccgattaatgaattaacagaatacgga cctgaaacaatagcgccaggtcatcgagacgaatttgatccgaagttaccaacaggagag aaagaggaagttccaggtaaaccaggaattaagaatccagaaacaggagacgtagttaga ccgccggtcgatagcgtaacaaaatatggacctgtaaaaggagactcgattgtagaaaaa gaagarattccattcragaaagaacgtaaatttaatccggatttagcaccagggacagaa aaagtaacaagagaaggacaaaaaggtgagaagacaataacgacgccaacactaaaaaat ccattaactggagaaattattagtaaaggtgaatcgaaagaagaaatcacaaaagatccg attaatgaattaacagaatacggaccagaaacgataacaccaggtcatcgagacgaattt gatccgaagttaccaacaggagagaaagaggaagttccaggtaaaccaggaattaagaat ccagaaacaggagacgtagttagaccaccggtcgatagcgtaacaaaatatggacctgta aaaggagactcgattgtagaaaaagaagaaattccattcaagaaagaacgtaaatttaat cctgatttagcaccagggacagaaaaagtaacaagagaaggacaaaaaggtgagaagaca ataacgacgccaacactaaaaaatccattaactg gagaaattattagtaaaggtgaatcg aaagaagaaatcacaaaagatccgattaatgaattaacagaatacggaccagaaacgata acaccaggtcatcgagacgaatttgatccgaagttaccaacaggagagaaagaggaagtt ccaggtaaaccaggaattaagaatccagaaacaggagatgtagttagaccaccggtcgat agcgtaacaaaatatggacctgtaaaaggagactcgattgtagaaaaagaagaaattcca ttcgagaaagaacgtaaatttaatcctgatttagcaccagggacagaaaaagtaacaaga gaaggacaaaaaggtgagaagacaataacgacgccaacactaaaaaatccattaactgga gaaattattagtaaaggtgaatcgaaagaagaaatcacaaaagatccagttaatgaatta acagaattcggtggcgagaaaataccgcaaggtcataaagatatctttgatccaaactta ccaacagatcaaacggaaaaagtaccaggtaaaccaggaatcaagaatccagacacagga aaagtgatcgaagagccagtggatgatgtgattaaacacggaccaaaaacgggtacacca gaaacaaaaacagtagagataccgtttgaaacaaaacgtgagtttaatccaaaattacaa cctggtgaagagcgagtgaaacaagaaggacaaccaggaagtaagacaatcacaacacca atcacagtgaacccattaacaggtgaaaaagttggcgagggtcaaccaacagaagagatc acaaaacaaccagtagataagattgtagagttcggtggagagaaaccaaaagatccaaaa ggacctgaaaacccagagaagccgagcagaccaactcatccaagtggcccagtaaatcct aacaatccaggattatcgaaagacagagcaaaaccaaatggcccagttcattcaatgg at aaaaatgataaagttaaaaaatctaaaattgctaaagaatcagtagctaatcaagagaaa aaacgagcagaattaccaaaaacaggtttagaaagcacgcaaaaaggtttgatctttagt agtataattggaattgctggattaatgttattggctcgtagaagaaagaat 19. atgaaaaataaatatatctcgaagttgctagttggggcagcaacaattacgttagctaca atgatttcaaatggggaagcaaaagcgagtgaaaacacgcaacaaacttcaactaagcac caaacaactcaaaacaactacgtaacagatcaacaaaaagctttttatcaagtattacat ctaaaaggtatcacagaagaacaacgtaaccaatacatcaaaacattacgcgaacaccca gaacgtgcacaagaagtattctctgaatcacttaaagacagcaagaacccagaccgacgt gttgcacaacaaaacgctttttacaatgttcttaaaaatgataacttaactgaacaagaa aaaaataattacattgcacaaattaaagaaaaccctgatagaagccaacaagtttgggta gaatcagtacaatcttctaaagctaaagaacgtcaaaatattgaaaatgcggataaagca attaaagatttccaagataacaaagcaccacacgataaatcagcagcatatgaagctaac tcaaaattacctaaagatttacgtgataaaaacaaccgctttgtagaaaaagtttcaatt gaaaaagcaatcgttcgtcatgatgagcgtgtgaaatcagcaaatgatgcaatctcaaaa ttaaatgaaaaagattcaattgaaaacagacgtttagcacaacgtgaagttaacaaagca cctatggatgtaaaagagcatttacagaaacaattagacgcattagttgctcaaaaagat gctgaaaagaaagtggcgccaaaagt tgaggctcctcaaattcaatcaccacaaattgaa aaacctaaagtagaatcaccaaaagttgaagtccctcaaattcaatcaccaaaagttgag gttcctcaatctaaattattaggttactaccaatcattaaaagattcatttaactatggt tacaagtatttaacagatacttataaaagctataaagaaaaatatgatacagcaaagtac tactataatacgtactataaatacaaaggtgcgattgatcaaacagtattaacagtacta ggtagtggttctaaatcttacatccaaccattgaaagttgatgataaaaacggctactta gctaaatcatatgcacaagtaagaaactatgtaactgagtcaatcaatactggtaaagta ttatatactttctaccaaaacccaacattagtaaaaacagctattaaagctcaagaaact gcatcatcaatcaaaaatacattaagtaatttattatcattctggaaa 20. atggccgtattttcaaaagagaaaaagagaggatgtatcgttgtgatagaaacatttaaa gcgtttgtaattgataaagatgagagtggtaaagtgacaccaactttcaaacaattatcg cctactgatttacctaaaggagatgtgctgattaaagtacattactctggtataaattat aaagatgctttagcgactcaagaccataatgcagtcgtaaaatcgtatcctatgattcca ggaatagatttagctggaacaattgttgaatccgaagcaccaggctttgaaaaaggagaa caagtaattgtaacgagttatgacctaggtgtcagccattatggcggttttagtgaatat gcgcgtgtaaaatcagaatggattatcaagcttcctgatactttaacattagaagaatca atgatatatggcacagctggttatactgccggtttagcaattgaaagacttgaaaaag tt ggaatgaatattgaagatggtcctgtactcgttcgcggtgcttcaggtggtgtcggtact ttagcagtactcatgcttaatgaacttggttataaagttatcgcaagtacaggtaaacaa gatgttagcgatcaattacttgaacttggtgccaaagaagttatcgatcgacttcctgtt gaagatgatcataaaaagccactcgcatcatcaacttggcaagcttgtgtagaccctgtt ggtggcgaaggtattaattatgttacaaagcgtttaaatcatagtgggtcaattgcagtt attggtatgactgccggtaatacttatactaattctgtattccctcacattttaagaggt gtaaacattttaggaattgactcggtatttactgctatgaaattaagacagcgcgtttgg cgtcgtctcgcaaaagatttaatgcctgaaaatttacatgagatcaagcaagttattaca tttgatgaacttccagaacaacttaacaaagtaattaaacatgaaaataaagggcgcatt gttatcgatttcggtgtagataaa 21. atgaaaaaattagtaacagcaactacgttaacagcaggaatcggcacagcattagtaggt caagcatatcatgcagatgctgctgaaaattatacaaattacaacaactataactacaac acgactcaaactacaacgactacgacaactacgacaactacatcatcaatttcacattct ggtaacttatacactgcaggacaatgtacttggtatgtatatgataaagttggcggagaa atcggttctacttggggaaatgctaataattgggctgctgctgcacaaggtgctggattc acagtaaatcatacaccttctaaaggcgctatcctacaatcttctgaaggaccatttggt cacgttgcatatgtagaaagtgtaaacagtgatggttcagttacaatttcaga aatgaat tatagtggcggacctttctcagtaagttctagaactatttctgcaagtgaagcaggtaac tacaactacatccatatt 22. atgaagaaaatcgctacagctactatcgcaactgcaggattcgctacaatcgcaattgca tcaggaaatcaagctcatgcttctgagcaagataactacggttataatccaaacgaccca acatcatatagctatacttacactattgatgcacaaggtaactaccattacacatggaaa ggtaactggcatccaagtcaattaaaccaagataatggctactacagctattactactac aatggttacaataactataacaattacaacaacggttatagctacaataactacagccgt tacaacaactactcaaataataatcaatcatataactacaataactataatagttacaac acaaacagctaccgtactggtggtttaggtgcaagctacagcacttcaagcaacaatgtt caagtaactacaactatggctccatcatcaaatggccgttcaatctcaagtggttatact tcaggacgtaacttatacacttctggtcaatgtacatactacgtatttgatcgtgtaggt ggtaaaatcggttcaacttggggcaatgcaagtaactgggctaacgcagctgcaagagct ggttacacagtgaacaatacaccaaaagctggtgcaattatgcaaacaactcaaggtgca tacggtcacgttgcatacgttgaaagtgttaacagcaatggttcagtaagagtttcagaa atgaactatggttatggcccaggtgttgtaacttcacgtacaatctcagctagccaagct gctggttataacttcattcac 23. atgtcaatgacatatagaataaagaaatggcaaaaattatccaccattacgttattaatg gctggtgtgattactttgaatggtggtg aattcagaagtgttgataaacatcaaatcgct gtggctgatacgaatgttcaaacgccagattatgaaaaattgaggaacacatggctggac gttaactatggttatgataagtatgatgagaataatccagatatgaagaagaagtttgat gctacagagaaagaggcgacgaatttactcaaggaaatgaaaactgaaagtggtaggaaa tacttgtggtcaggagcggaaacccttgaaactaattcttctcatatgactcgtacctat cgtaatattgagaaaatcgcagaagcgatgaggaatcctaaaaccactttaaatactgac gaaaataagaagaaagtgaaagatgcccttgagtggctgcataaaaatgcatatggaaaa gaaccagataaaaaagtaaaagaattaagtgagaattttactaaaacaactggcaagaat accaacttaaattggtgggattatgaaattggaacacctaaatcattaacaaatacgctt atattgctgaatgatcaattttcaaatgaagaaaagaaaaaattcactgcccctattaaa actttcgccccagatagtgacaaaatattatcttctgtaggaaaagctgaacttgctaaa ggcggaaatctagtagacatttctaaggtgaaacttttagaatgtattatcgaagaagat aaagatatgatgaaaaagtctatagattcatttaataaagtcttcactwacgttcaagat tctgccactggtaaagaacgtaatggattttataaagatggctcttacattgatcatcaa gacgttccatacactggtgcttatggcgttgtactcttagaggggatttctcaaatgatg ccgatgataaaagaaacaccttttaatgataaaacccaaaatgatacaaccttaaagtca tggattgacgacggatttatgccactcatttataaaggtgaaatgatggatt tatcacga ggtagagctatcagtcgtgaaaatgaaaccagtcactcagcatctgcaacagtaatgaaa tcattgttgagattaagtgatgccatggatgattcaacaaaagctaagtataaaaagatt gtcaaatcttcagtagagtcagattcaagttataaacaaaatgattatttaaattcatat tcggacatagataaaatgaagtctttaatgacagataacagtatttctaaaaacggatta acacaacaacttaaaatatataatgacatggatcgtgtcacctatcataacaaagactta gactttgcatttggtttaagtatgacgtcgaaaaacgtagcacgctatgaaagtatcaac ggagagaatttaaaaggttggcacactggtgctggaatgtcttatttatataacagcgat gtcaaacactatcatgataacttctgggtgacagccgatatgaaacgtttatcaggtaca acaactttagacaatgaaatattaaaagatacggatgataaaaagtcgagtaaaactttt gttggcggaacaaaagttgatgaccaacatgctagtatcggaatggattttgaaaatcag gacaaaactttaactgccaaaaaatcatatttcatattaaacgataaaattgtcttctta ggaactggcattaaaagtactgattcatcaaagaatccagttacaacgattgaaaatcgc aaagcgaatgggtatacgttatatacagacgataaacaaacaaccaattctgataatcag gaaaacaattcagtctttttagagtccacagataccaaaaagaacatcggttatcatttt ttaaacaaaccgaaaataactgtaaaaaaagaaagtcatactggtaagtggaaagaaata aataaaagtcaaaaggatacacaaaaaactgatgagtattatgaagtaactcaaaagcat tctaattctgacaat aaatatggatatgtgttgtatccaggcttatctaaagatgtcttt aagacaaaaaaagatgaagtaactgtcgttaagcaagaagatgacttccacgttgtgaaa gataatgaatcggtttgggctggtgttaattatagtaatagcactcaaacttttgacatt aacaacactaaagtcgaagttaaagccaaaggtatgtttatacttaaaaagaaagatgat aacacttatgaatgtagcttctataatcctgaatctacaaattccgcttcagatattgaa tctaaaatttcaatgaccggttactctattacaaacaaaaatacgtcgacttctaatgaa tccggcgtgcactttgaattaactaaa 24. gtgaatgatttgaagcaatttctatatattgcgttagtatgtggtgtgatagcaggtctt ggtgctttcttacatataccgcagtatccgagcatgacaattccacgtatagtagctatt ttaggaattatcagtgctatgttgacttttaaagacaagcaaatcagcgcctcattaaag tttagcgcattgttaattaatgtgctgccattatgcggtacctttgtagcttcaaat 25. gtgtctcgtgaaatgtcatatcattggtttaagaaaatgttactttcaacaagtatttta attttaagtagtagtagtttagggcttgcaacgcacacagttgaagcaaaggataactta aatggagaaaaaccaactactaatttgaatcataatataacttcaccatcagtaaatagt gaaatgaataataatgagactgggacacctcacgaatcaaatcaaacgggtaatgaagga acaggttcgaatagtcgtgatgctaatcctgattcgaataatgtgaagccagactcaaac aaccaaaacccaagtacagattcaaaaccagacccaaataaccaaaacccaagtccgaat cctaaa ccagatccagataacccgaaaccaaaaccggatccaaaaccagacccagataaa ccaaagccaaatccggatccaaaaccagatccagataacccgaaaccaaatccagatcca aaaccagacccagataaaccaaagccaaatccggatccaaaaccagatccagataaacca aagccaaatccgaatccaaaaccagaccctaataagccaaatcctaacccgtcaccagat cccgatcaacctggggattccaatcattctggtggctcgaaaaatggggggacatggaac ccaaatgcttcagatggatctaatcaaggtcaatggcaaccaaatgggaatcaaggaaac tcacaaaatcctactggtaatgattttgtatcccaacgatttttagccttggcaaatggg gcttacaagtataatccgtatattttaaatcaaattaataagttgggcaaagattatgga gaagttactgatgaagacatttataatattattcgaaaacaaaatttcagcggaaatgca tatttaaatggattacaacagcaatcgaattactttagattccaatatttcaatccattg aaatcagaaaggtactatcgtaatttagatgaacaagtactcgcattaattactggtgaa attggatcaatgccagatttgaaaaagcccgaagataagccggattcaaaacaacgctca tttgaaccgcatgaaaaagacgattttacagtagttaaaaaacaagaagataataagaaa agtgcgtcaactgcatatagtaaaagttggctagcaattgtatgttctatgatggtggta ttttcaatcatgctattcttatttgtaaagcgaaataaaaagaaaaataaaaacgaatca cagcgacga 26. atgaaaaataaaaaacgtgttttaatagcgtcatcattatcatgtgcaattttattgtta tcagcagcaacgactc aagcaaattcagctcataaagactctcaagaccaaaataagaaa gaacatgttgataagtctcaacaaaaagacaaacgtaatgttactaataaagataaaaat tcaacagcaccggatgatattgggaaaaacggtaaaatcacaaaacgaactgaaacagta tatgatgagaaaacaaatatactccaaaatttacaattcgactttatcgatgatccaact tatgacaagaatgtattacttgttaaaaaacaaggctcaattcattcaaatttaaagttt gaatctcataaagaagaaaaaaattcaaattggttaaagtatccaagtgagtaccatgta gattttcaagtaaaaagaaatcgtaaaactgaaatattagaccaattgccgaaaaataaa atttcaactgcaaaagtagacagtacattttcatatagctcaggtggtaaattcgattca acaaaaggtattggacgaacttcatcaaatagctactccaaaacgattagttataatcag caaaattatgacacaattgccagcggtaaaaataataactggcatgtacactggtcagtt attgcgaatgacttgaagtatggtggagaagtgaaaaatagaaatgatgaattattattc tatagaaatacgagaattgctactgtagaaaaccctgaactaagctttgcttcaaaatat agatacccagcattagtaagaagtggctttaatccagaatttttaacttatttatctaat gaaaagtcaaatgagaaaacgcaatttgaagtaacatacacacgaaatcaagatattttg aaaaacagacctggaatacattatgcacctccaattttagaaaaaaataaagatggtcaa agattaattgtcacttatgaagttgattggaaaaataaaacagttaaagtcgttgataaa tattctgatgacaataaaccttataaagaagga 27. at gtatacacgtacagctacaacaagtgatagtcaaaaaaatattactcaaagcttacaa tttaatttcttaactgaacctaattatgataaagaaacagtatttattaaagcaaaaggt acaattggtagtggtttgagaattttagacccaaatggttattggaatagtacattaaga tggcctggatcttattcagtttcaattcaaaatgttgatgacaacaacaatacaaatgtg actgactttgcaccaaaaaatcaggatgaatcaagagaagttaaatatacgtatggttat aaaacaggtggagatttttcgattaatcgtggaggcttaactggaaatattacaaaagag agtaattattcagagacgattagttatcaacaaccatcatatcgtacattacttgatcaa tctacgtcacataaaggtgtaggttggaaagtagaagcacatttgataaataatatggga catgaccatacgagacaattaactaatgatagtgataatagaactaaaagtgaaattttt tctttaacacgaaatggaaatttatgggcgaaagataatttcacacctaaagacaaaatg cctgtaactgtgtctgaagggtttaatccagaatttttagctgttatgtcacatgataaa aaagacaaaggtaaatcacaatttgttgttcattataaaagatcaatggatgagtttaaa atagattggaatcgccatggtttctggggctattggtctggtgaaaaccatgtagataaa aaagaagaaaaattatcagcattatatgaagttgattggaagacacataatgtgaagttt gtaaaagtacttaatgataatgaaaagaaa 28. gtggtgaaatttatgaattatccaaatggtaaaccatatcgtaaaaatagtgctatagac ggagggaaaaagaccgctgcctttagtaatattgagtatggtggacgtggta tgtcactt gaaaaagatatcgaacattcaaatacgttttatcttaaaagcgacattgcagttattcac aaaaagcctacgccagtacaaatagttaatgtcaactatcctaagcggagtaaagctgtg attaacgaagcttattttcgtacaccttcaacaactgattacaacggcgtttatcaaggt tattatattgattttgaagcaaaggaaactaaaaacaagacgtcctttcctttaaataat attcatgaccatcaagtcgaacatatgaaaaatgcatatcaacaaaaaggtattgtgttt ttaatgattcgttttaaaacgctagatgaagtttatcttttaccctattcaaaattcgaa gtattttggaagagatataaagataatattaaaragtctataacagttgatgaaatacga aaaaatggttaccatattccttatcagtatcaaccaagattagactatctaaaagcagtt gataagttgatattagatgaaagtgaggaccgcgta 29. gtgaatacaacgaaagcagcattacatggtgatgtgaagttacaaaatgataaagatcat gctaagcaaacggttagtcaattagcacatctaaacaatgcacaaaaacatatggaagat acgttaattgatagtgaaacaactagaacagcagttaagcaagatttgactgaagcacaa gcattagatcaacttatggatgcattacaacaaagtattgctgacaaagatgcaacacgt gcgagcagtgcatatgtcaatgcagaaccgaataaaaaacaatcctatgatgaagcagtt caaaatgctgagtctatcattgcaggattaaataatccaactatcaataaaggtaatgta tcaagtgcgactcaagcagtaatatcatctaaaaatgcattagatggtgttgaacgatta gctcaagataagcaaactgctggaaattctctaaa tcatttagatcaattaacaccagct caacaacaagcgctagaaaatcaaattaataatgcaacaactcgtggcgaagtagcacaa aaattaactgaagcacaagcacttaaccaagcaatggaagctttacgtaatagcattcaa gatcaacagcaaacggaagcgggtagcaagtttatcaatgaagataaaccacaaaaagat gcttaccaagcagcagttcaaaatgcaaaagatttaattaatcaaactaacaatccaacg cttgataaagcacaagttgaacaattgacacaagctgttaaccaagctaaagataaccta cacggtgatcaaaaacttgcagacgataaacaacatgcggttactgatttaaatcaatta aatggtttgaataatccgcaacgtcaagcacttgaaagccaaataaacaacgcagcaact cgtggcgaagtagcacaaaaattagctgaagcaaaagcgcttgatcaagcaatgcaagca ttacgtaatagtattcaagatcaacaacaaacagaatctggtagcaagtttatcaatgaa gataaaccgcaaaaagatgcttaccaagcagcagttcaaaatgcaaaagatttaattaac caaacaggtaatccaacactcgacaaatcacaagtagaacaattgacacaagcagtaaca actgcaaaagataatctacatggtgatcaaaaacttgctcgtgatcaacaacaagcagta acaactgtaaatgcattgccaaacttaaatcatgcacaacaacaagcattaactgatgct ataaatgcagcgcctacaagaacagaggttgcacaacatgttcaaactgctactgaactt gatcacgcgatggaaacattgaaaaataaagttgatcaagtgaatacagataaggctcaa ccaaattacactgaagcgtcaactgataaaaaagaagcagtagatcaagcgttacaagc t gcagaaagcattacagatccaactaatggttcaaatgcgaataaagacgctgtagaccaa gtattaactaagcttcaagaaaaagaaaatgagttaaatggtaatgagagagtcgctgaa gctaaaacacaagcgaaacaaactattgaccaattaacacatttaaatgctgatcaaatt gcaactgctaaacaaaacattgatcaagcgacgaaacttcaaccaattgctgaattagta gatcaagcaacgcaattgaatcaatctatggatcaattacaacaagcagttaatgaacat gctaacgttgagcaaactgtagattacacacaagcagattcagataaacaaaatgcttat aaacaagctattgctgatgctgaaaatgtattgaaacaaaatgcgaataagcaacaagtg gatcaagcacttcaaaatattttaaatgcaaaacaagcattaaatggtgatgaacgtgta gcacttgctaaaacaaatggtaaacatgacatcgaccaattgaatgcattaaacaatgct caacaagatggatttaaaggtcgcatcgatcaatcaaacgatttaaatcaaatccaacaa attgtagatgaggctaaggcacttaatcgtgcaatggatcaattgtcacaagaaatcact gacaatgaaggacgcacgaaaggtagcacgaactatgtcaatgcagatacacaagtcaaa caagtatatgatgaaacggttgataaagcgaaacaagcacttgataaatcgactggtcaa aacttaactgcaaaacaagttatcaaattaaatgatgcagtcactgcagctaagaaagca ttaaatggtgaagaaagacttaataatcgtaaagctgaagcattacaaagattggatcaa ttaacacatctaaacaatgctcaaagacaattagcaatccaacaaattaataatgctgaa acgctaaataaagcatctcgag caattaatagagcaactaaattagataatgcaatgggt gcagtacaacaatatattgacgaacagcaccttggtgttatcagcagcacaaattacatc aatgcagatgacaatttgaaagcaaattatgataatgcaattgcgaatgcagcacatgag ttagataaagtgcaaggtaatgcaattgcaaaagctgaagcagagcaattgaaacaaaat attatcgatgctcaaaatgcattaaatggagaccaaaaccttgcaaatgccaaagataaa gcaaatgcgtttgttaattcgttaaatggattaaatcaacagcaacaagatcttgcacat aaagcaattaacaatgccgatactgtatcagatgtaacagatattgttaataatcaaatt gacttaaatgatgcaatggaaacattgaaacatttagttgacaatgaaattccaaatgca gagcaaactgtcaattaccaaaacgctgacgataatgctaaaacaaacttcgatgatgcc aaacgtctagcaaatacattgctaaatagtgataacacaaatgtgaatgatatcaatggc gcaatccaagcagtcaatgatgcaatccataatcttaatggtgatcaacgactacaagat gctaaagacaaggcaattcaatctattaatcaagctttagctaataagctaaaagaaatc gaagcttcaaatgcgacggatcaagacaagcttattgcgaaaaataaagcagaagaattg gcaaacagcatcatcaacaacattaataaagcaacaagtaatcaggctgtatctcaagtt caaacagcaggcaaccacgcgattgaacaagtgcatgccaatgaaataccaaaagcaaaa attgatgccaataaagacgttgataagcaagttcaagcattaattgacgaaattgatcga aatccaaatctaacagataaggaaaaacaagcacttaaagatcgta ttaatcaaatactt caacaaggtcataacggcattaacaatgcgatgactaaagaagaaattgaacaagccaaa gcacaacttgcgcaagcattacaagacatcaaagatttagtgaaagctaaagaagatgcg aaacaagatgttgataaacaagttcaagctttaattgacgaaatcgatcaaaatccaaat ctaacagataaggaaaaacaagcacttaaagatcgtattaatcaaatacttcaacaaggt catarcgacattamcaatgcgatgacaaaagaagcaattgaacaagcaaaagaacgttta gcgcaagcattgcaagacatcaaagatttagtgaaagctaaagaagatgcgaaaaatgat attgataaacgtgtacaagctttaattgacgaaatcgatcaaaatccaaatctaacagat aaggaaaaacaagcacttaaagatcgaattaatcaaatacttcaacaaggtcataacgac attaacaatgcgctgactaaagaagaaattgagcaggcaaaagcacaacttgcacaagca ttgcaagacatcaaagatttagtgaaagctaaagaagatgcgaaaaatgcaataaaagcc ttagctaatgcgaagcgtgatcaaatcaattcaaatccagatttaacacctgagcaaaaa gcaaaagcgctcaaagaaattgacgaagctgaaaaacgagcactacaaaacgttgagaat gctcaaactatagatcaattaaatcgaggattaaacttaggtttagatgacattagaaat acacatgtatgggaggttgatgaacaacctgctgtaaatgaaatttttgaagcaacacct gagcaaatcctagttaatggtgaactcattgtacatcgtgatgacatcattacagaacaa gatattcttgcacacataaacttaattgatcagctttcagcagaagtcatcgatacacca tcaactgca acgatttctgatagcttaacagcaaaagttgaagttacattgcttgatgga tcaaaagtgattgttaatgttcctgtaaaagttgtagaaaaagaattgtcagtagtcaaa caacaggcaattgaatcaatcgaaaatgcggcacaacaaaagattaatgaaatcaataat agtgtgacattaacactggaacaaaaagaagctgcaattgcagaagttaataagcttaaa caacaagcaattgatcatgttaacaatgcacctgatgttcattcagttgaagaaattcaa caacaagaacaagcgcatattgaacaatttaatccagaacaatttacgattgaacaagca aaatcaaatgcaattaaatcgattgaagatgcaattcaacatatgattgatgaaatcaaa gctcgtactgatctaacagataaagagaagcaagaagctattgctaagttaaatcaatta aaagaacaagcaattcaagcgattcaacgtgcgcaaagcatcgatgaaataagtgagcaa ttggaacaatttaaagctcaaatgaaagcagctaatccaacagcaaaagaactagctaaa cgcaagcaagaagctattagtagaattaaagacttttcaaatgaaaaaataaatagtatt cgaaatagtgaaattggcacagctgatgaaaaacaagcagcaatgaatcaaattaacgaa attgtgcttgaaacaattagagatattaataatgcgcatacattacagcaagttgaggct gcattgaacaatggtattgctcgaatttcagcagtacaaattgtaacatctgatcgtgct aaacaatcgtcaagtactggaaatgaatctaatagccatttaacaattggttatggaact gcaaatcatccatttaacagttcgactattggacataaaaagaaacttgatgaagatgat gacattgatccacttcatatgcgtcactttagt aataatttcggtaatgttattaaaaac gctattggtgtggtgggtatctctggtttactagctagtttctggttcttcattgccaaa cgtcgtcgtaaagaagatgaagaggaagaattagaaataagagataataataaagattca ataaaagagactttagacgatacaaaacatttaccacttttatttgcgaaacgtcgcaga aaagaagatgaagaagatgttactgttgaagaaaaagattcgctaaataatggcgagtca ctcgataaagttaaacatacgccgttcttcttaccaaaacgtcgtcgtaaagaagatgaa gaagatgtggaagttacaaatgaaaacacagatgaaaaagtgttgaaagataacgaacat tcaccactcttattcgcaaaacgacgcaaagataaagaggaagatgttgaaacaacaact agtattgaatctaaagatgaggacgttcctttattattggctaaaaagaaaaatcaaaaa gataaccaatccaaagacaaaaagtcagcatcaaaaaatacttctaaaaaggtagcagct aaaaagaagaaaaagaaagctaagaaaaataaaaaa 30. atgaatcaggaagttaaaaacaaaatattttcaatcttaaaaattacgtttgctacagct ttatttatttttgtagcaatcacattgtatcgggagttatctggtattaactttaaagat acgttggttgaatttagtaagattaaccgtatgtccttagtgttactatttattggtggt ggggcatcgcttgttattctatcaatgtatgatgtgattttatctagagctttaaaaatg gatatatccttaggcaaagttttaagagtaagttatatcatcaatgcattgaatgcgatt gtaggtttcggtggctttattggtgcaggcgttagagcaatggtttataaaaactatacg catgataaaaagaaat tagttcactttatatccttaatacttatttcaatgttgacaggt ttaagcttattatcattgctaattgtattccatgttttcgatgcatctttaatcttagat aagattacatgggtaagatgggtattatatgtagtgtcatttttcttaccattattcatt atttattcaatggttagaccacccgataaaaacaatcgttttgtaggattgtactgcact ttagtgtcgtgtgttgaatggttagcagctgcagttgtattatatttctgtggtgtaatt gttgacgctcatgtatcattcatgtcctttattgcaatatttatcattgctgcattatca ggtttagtcagctttattcctggtggtttcggcgctttcgatttagttgtattactagga tttaaaactttaggtgtccctgaggaaaaagtattattaatgctacttctatatcgtttt gcgtactattttgtaccggtaattattgcattaattttatcatcatttgaatttggtaca tcagctaagaagtacattgagggatctaaatactttattcctgctaaagatgttacgtca tttttaatgtcttatcaaaaggatattattgctaaaattccatcattatcattagcaatt ttagtattctttacaagtatgatcttttttgtaaataacttaacgattgtttacgatgct ttatatgatggaaatcacttaacgtattatattctattggcaattcatactagtgcttgt ttattacttttactgaatgtagttggtatttataagcaaagtagacgtgccattatcttt gctatgatttcaattttattaatcacagtggcgacattcttcacttacgcttcatatatt ttaataacatggttagctattatttttgttctgcttattgtagctttccgtagagcacgt aggttgaaacgcccagtaagaatgagaaatatagttgcaa tgcttttattcagtttattt attttatatgttaaccatatatttattgctggaacgttatatgcattagatatttatacg attgaaatgcatacatctgtattgcgctattacttctggcttacgattttaatcatcgct atcatcataggtatgattgcatggttgtttgattatcaatttagcaaagtacgtatttct tctaaaattgaagattgcgaggagattattaatcagtacggcggtaattatttgagtcac ttgatatatagtggtgacaagcagtttttcactaatgaaaataaaacagcatttttaatg tatcgttataaagcaagttcattagtggttcttggagatccgttaggtgatgaaaatgcc tttgatgaattgttagaagcattctataattacgctgagtatttaggctatgatgttata ttctatcaagttacagatcaacacatgcctttatatcataatttcggtaaccaatttttc aaattaggtgaagaagcaattattgatttaacgcaattttcaacttcaggtaaaaaacgc cgtggatttagagcgactttaaataaattcgatgaacttaatatttcgttcgaaattatt gaaccaccgttttcaactgaatttataaatgaacttcaacatgtaagtgatttatggcta gataatcgtcaggaaatgcatttctctgttggtgaatttaatgaagaatacttatctaaa gcgccaattggtgtaatgcgaaatgaagaaaatgaagtaattgcattttgtagtttaatg ccaacatactttaatgatgccatttcagtcgatttaattagatggttgccagagttagat ttaccattaatggatggtctatacttgcatatgttactttggagtaaagaacaaggttat acaaaatttaatatgggtatggcaacgttatcgaacgttggtcaattgcattattcatat tta agagaacgacttgcaggccgtgtctttgaacatttcaacggtctatatcgtttccaa ggattacgtcgttataaatctaaatataatccgaattgggaaccacgctttttagtttat cgtaaagataattcgctttgggaatcactttctaaagtaatgcgtgtaatacgtcacaaa 31. atggttgcattaacgcttgtaggttcagcagtcactgcacatcaagttcaagcagctgag acgacacaagatcaaactactaataaaaacgttttagatagtaataaagttaaagcaact actgaacaagcaaaagctgaggtaaaaaatccaacgcaaaacatttctggcactcaagta tatcaagaccctgctattgtccaaccaaaaacagcaaataacaaaacaggcaatgctcaa gtaagtcaaaaagttgatactgcacaagtaaatggtgacactcgtgctaatcaatcagcg actacaaataatacgcagcctgttgcaaagtcaacaagcactacagcacctaaaactaac actaatgttacaaatgctggttatagtttagttgatgatgaagatgataattcagaaaat caaattaatccagaattaattaaatcagctgctaaacctgcagctcttgaaacgcaatat aaaaccgcagcacctaaagctgcaactacatcagcacctaaagctaaaactgaagcgaca cctaaagtaactacttttagcgcttcagcacaaccaagatcagttgctgcaacaccaaaa acgagtttgccaaaatataaaccacaagtaaactcttcaattaacgattacattcgtaaa aataacttaaaagcacctaaaattgaagaagattatacatcttacttccctaaatacgca taccgtaacggcgtaggtcgtcctgaaggtatcgtagttcatgatacagctaatgatcgt tcgacgataaatggtgaaattag ttatatgaaaaataactatcaaaacgcattcgtacat gcatttgttgatggggatcgtataatcgaaacagcaccaacggattacttatcttggggt gtcggtgcagtcggtaaccctagattcatcaatgttgaaatcgtacacacacacgactat gcttcatttgcacgttcaatgaataactatgctgactatgcagctacacaattacaatat tatggtttaaaaccagacagtgctgagtatgatggaaatggtacagtatggactcactac gctgtaagtaaatatttaggtggtactgaccatgccgatccacatggatatttaagaagt cataattatagttatgatcaattatatgacttaattaatgaaaaatatttaataaaaatg ggtaaagtggcgccatggggtacgcaatctacaactacccctactacaccatcaaaacca acaacaccgtcgaaaccatcaactggtaaattaacagttgctgcaaacaatggtgtcgca caaatcaaaccaacaaatagtggtttatatactactgtatacgacaaaactggtaaagca actaatgaagttcaaaaaacatttgctgtatctaaaacagctacattaggtaatcaaaaa ttctatcttgttcaagattacaattctggtaataaatttggttgggttaaagaaggcgat gtggtttacaacacagctaaatcacctgtaaatgtaaatcaatcatattcaatcaaacct ggtacgaaactttatacagtaccttggggtacatctaaacaagttgctggtagtgtgtct ggctctggaaaccaaacatttaaggcttcaaagcaacaacaaattgataaatcaatttat ttatatggctctgtgaatggtaaatctggttgggtaagtaaagcatatttagttgatact gctaaacctacgcctacaccaacacctaagccatcaacacctacaac aaataataaatta acagtttcatcattaaacggtgttgctcaaattaatgctaaaaacaatggcttattcact acagtttatgacaaaactggtaagccaacgaaagaagttcaaaaaacatttgctgtaaca aaagaagcaagtttaggtggaaacaaattctacttagttaaagattacaatagtccaact ttaattggttgggttaaacaaggtgacgttatttataacaatgcaaaatcacctgtaaat gtaatgcaaacatatacagtaaaaccaggcactaaattatattcagtaccttggggcact tataaacaagaagctggtgcagtttctggtacaggtaaccaaacttttaaagcgactaag caacaacaaattgataaatctatctatttatttggaactgtaaatggtaaatctggttgg gtaagtaaagcatatttagctgtacctgctgcacctaaaaaagcagtagcacaaccaaaa acagctgtaaaagcttatactgttactaaaccacaaacgactcaaacagttagcaagatt gctcaagttaaaccaaacaacactggtattcgtgcttctgtttatgaaaaaacagcgaaa aacggtgcgaaatatgcagaccgtacgttctatgtaacaaaagagcgtgctcatggtaat gaaacgtatgtattattaaacaatacaagccataacatcccattaggttggttcaatgta aaagacttaaatgttcaaaacttaggcaaagaagttaaaacgactcaaaaatatactgtt aataaatcaaataacggcttatcaatggttccttggggtactaaaaaccaagtcatttta acaggcaataacattgctcaaggtacatttaatgcaacgaaacaagtatctgtaggcaaa gatgtttatttatacggtactattaataaccgcactggttgggtaaatgcaaaagattta actgcaccaa ctgctgtgaaaccaactacatcagctgccaaagattataactacacttat gtaattaaaaatggtaatggttattactatgtaacaccaaattctgatacagctaaatac tcattaaaagcatttaatgaacaaccattcgcagttgttaaagaacaagtcattaatgga caaacttggtactatggtaaattatctaacggtaaattagcatggattaaatcaactgat ttagctaaagaattaattaagtataatcaaacaggtatggcattaaaccaagttgctcaa atacaagctggtttacaatataaaccacaagtacaacgtgtaccaggtaagtggacaggt gctaactttaatgatgttaagcatgcaatggatacgaagcgtttagctcaagatccagca ttaaaatatcaattcttacgcttagaccaaccacaaaatatttctattgataaaattaat caattcttaaaaggtaaaggtgtattagaaaaccaaggtgctgcatttaacaaagctgct caaatgtatggcattaatgaagtttatcttatctcacatgccctattagaaacaggtaac ggtacttctcaattagcgaaaggtgcagatgtagtgaacaacaaagttgtaactaactca aacacgaaataccataacgtatttggtattgctgcatatgataacgatcctttacgtgaa ggtattaaatatgctaaacaagctggttgggacacagtatcaaaagcaatcgttggtggt gctaaattcatcggcaactcatatgtaaaagctggtcaaaatacactttacaaaatgaga tggaatcctgcacatccaggaacacaccaatatgctacagatgtagattgggctaacatc aatgctaaaatcatcaaaggctactatgataaaattggcgaagtcggcaaatacttcgac atcccacaatataaa 32. atgaaaggtaaatt tttaaaagttagttctttattcgttgcaactttgacaacagcgaca cttgtgagttctccagcagcaaacgcgttatcttcaaaggctatggacaatcatccacaa caaacgcagtcaagcaaacagcaaacacctaagattcaaaaaggcggtaaccttaaacca ttagaacaacgtgaacacgcaaatgttatattaccaaataacgatcgtcaccaaatcaca gatacaacgaatggtcattatgcacccgtaacttatattcaagttgaagcacctactggt acatttattgcttccggtgtagttgtaggtaaagatactcttttaacraataaacacgtc gtagatgctacgcacggtgatcctcatgctttaaaagcattcccttctgcaattaaccaa gacaattatccaaatggtggtttcactgctgaacaaatcactaaatattcagacgaaggt gatttagcaatagttaaattctcccctaatgagcaacacaaacatattggtgaagtagtt aaaccagcaacaatgagtaataatgctgacactcaagttaaccaaaatattactgtaaca ggatatcctggtgataaacctgtagcaacaatgtgggaaagtaaaggaaaaatcacttac ctcaaaggcgaagctatgcaatatgatttaagtacaactggtggtaattcaggttcacct gtatttaatgaaaaaaatgaagtgatcggaattcattgggncggtgtaccaaatgaattt aatggtgcggtatttattaatgaaaatgtacgcaacttcttaaaacaaaatattgaagat atccattttgccacgatgaccaacctaataacccagataatcctgataaccctaacaatc ctgataaccctaacaacccagatgaaccaaataaccctgacaaccctaacaaccctgata atccagacaatggcgatamcaataattcagacaatcca gatgcagcttaat 33. gtgcaaaaaaaagtaattgcagctattattgggacaagcgcgattagcgctgttgcggca actcaagcaaatgcggctacaactcacacagtaaaaccgggtgaatcagtgtgggcaatt tcaaataagtatgggatttcgattgctaaattaaagtcattaaacaatttaacatctaat ctaattttcccaaaccaagtactaaaagtatctggctcaagtaattctacgagtaatagt agccgtccatcaacgaactcaggtggcggatcatactacacagtacaagcaggcgactca ttatcattaatcgcatcaaaatatggtacaacttaccaaaacattatgcgacttaatggt ttaaataatttctttatttatccaggtcaaaaattaaaagtatcaggtactgctagctca agtaacgctgcgagcaatagtagccgtccatcaacgaactcaggtggcggatcatactat acagtacaagcaggtgactcattgtcattaattgcatcaaaatatggtacaacttatcaa aaaattatgagcttaaatggcttaaataatttctttatatatccgggtcaaaaattgaaa gtaactggtaatgcatctacgaactcaggatctgcaacaacgacaaatagaggttacaat acaccagtattcagtcaccaaaacttatatacatggggtcaatgtacatatcatgtattt aatcgtcgtgctgaaattggtaaaggtattagtacttattggtggaatgctaataactgg gataacgcagcggcagcagatggttacactatcgacaatagacctactgtaggttctatc gctcaaacagatgtaggttactatggtcatgttatgtttgtagaacgtgtaaataacgat ggtagtattttagtttcagaaatgaactattcagctgcaccaggtattttaacttacaga acggta ccagcttaccaagtaaataattatagatatattcac 34. atgaataataaaaagacagcaacaaatagaaaaggcatgataccaaatcgattaaacaaa ttttcgataagaaagtattctgtaggtactgcttcaattttagtagggacaacattgatt tttgggttaagtggtcatgaagctaaagcggcagaacatacgaatggagaattaaatcaa tcaaaaaatgaaacgacagccccaagtgagaataaaacaactaaaaaagttgatagtcgt caactaaaagacaatacgcaaactgcaactgcagatcagcctaaagtgacaatgagtgat agtgcaacagttaaagaaactagtagtaacatgcaatcaccacaaaacgctacagctaat caatctactacaaaaactagcaatgtaacaacaaatgataaatcatcaactacatatagt aatgaaactgataaaagtaatttaacacaagcaaaagatgtttcaactacacctaaaaca acgactattaaaccaagaactttaaatcgcatggcagtgaatactgttgcagctccacaa caaggaacaaatgttaatgataaagtacatttttcaaatattgacattgcgattgataaa ggacatgttaatcagactactggtaaaactgaattttgggcaacttcaagtgatgtttta aaattaaaagcaaattacacaatcgatgattctgttaaagagggcgatacatttactttt aaatatggtcaatatttccgtccaggatcagtaagattaccttcacaaactcaaaattta tataatgcccaaggtaatattattgcaaaaggtatttatgatagtacaacaaacacaaca acatatacttttacgaactatgtagatcaatatacaaatgttagaggtagctttgaacaa gttgcatttgcgaaacgtaaaaatgcaacaactgataaaacagc ttataaaatggaagta actttaggtaatgatacatatagcgaagaaatcattgtcgattatggtaataaaaaagca caaccgcttatttcaagtacaaactatattaacaatgaagatttatcgcgtaatatgact gcatatgtaaatcaacctaaaaatacatatactaaacaaacgtttgttactaatttaact ggatataaatttaatccaaatgcaaaaaacttcaaaatttacgaagtgacagatcaaaat caatttgtggatagtttcacccctgatacttcaaaacttaaagatgttactgatcaattc gatgttatttatagtaatgataataaaacagctacagtcgatttaatgaaaggccaaaca agcagcaataaacaatacatcattcaacaagttgcttatccagataatagttcaacagat aatggaaaaattgattatactttagacactgacaaaactaaatatagttggtcaaatagt tattcaaatgtgaatggctcatcaactgctaatggcgaccaaaagaaatataatctaggt gactatgtatgggaagatacaaataaagatggtaaacaagatgccaatgaaaaagggatt aaaggtgtttatgtcattcttaaagatagtaacggtaaagaattagatcgtacgacaaca gatgaaaatggtaaatatcagttcactggtttaagcaatggaacttatagtgtagagttt tcaacaccagccggttatacaccgacaactgcaaatgtaggtacagatgatgctgtagat tctgatggactaactacaacaggtgtcattaaagacgctgacaacatgacattagatagt ggattctacaaaacaccaaaatatagtttaggtgattatgtttggtacgacagtaataaa gatggtaaacaagattcgactgaaaaaggaattaaaggtgttaaagttactttgcaaaac gaaaaag gcgaagtaattggtacaactgaaacagatgaaaatggtaaataccgctttgat aatttagatagtggtaaatacaaagttatctttgaaaaacctgctggcttaactcaaaca ggtacaaatacaactgaagatgataaagatgccgatggtggcgaagttgatgtaacaatt acggatcatgatgatttcacacttgataatggctactacgaagaagaaacatcagatagc gactcagattctgacagcgattcagactcagatagcgactcagattcagatagcgactca gattcagacagcgattcagacagcgactcagactcagatagcgattcagattcagacagc gactcagactcagacagcgattcagactcggatagcgactcagactcagatagcgactca gattcggatagcgactcagactcagatagcgattcagattcagatagcgattcggactca gacagtgattcagattcagactcagatagcgactcagattctgacagcgattcagactca gacagcgactcagactcagacagtgattcagattcagacagcgactcagattcagatagc gactcagactcagatagcgactcagactcagatagcgactcagactcggatagcgattca gattcagacagcgactcagattcagatagcgattcggactcagacaacgactcagattca gatagcgattcagattcagatgcaggtaaacatactccggctaaaccaatgagtacggtt aaagatcagcataaaacagctaaagcattaccagaaacaggtagtgaaaataataattca aataatggcacattattcggtggattattcgcggcattaggatcattattgttattcggt cgtcgtaaaaaacaaaataaa 35. atggacataaattcagaagaatacaaacaagaggtacttatcaaagacgttgtcatgctt gctgc tcgcatactattagaatctggtgcagaaggtacgcgtgtagaagataccatgaca cgtattgcaaaaaaacttggttacagtgaaagtaacagctttgttacaaacactgtcatc cagtttacgttacattcggaatcgtttcctagaatatttagaattacctctcgagataca aacttaataaaaatttctcaagctaataaaatttcgcgtcaaattacaaacaatgaaatt tctttagccgaagcaaaaacgcaacttgaaaaaatatatgttgctaagcgtgacagcagt cttccctttaaaggttttgctgcagcaatgattgcaatgagtttcttatatttacaaggt ggtagattgattgatgttttaactgcgatattagcaggtagtctaggatacctagtcact gagattttagatcgtaagttacacgcacagtttatcccagaattcattggttcattagtt attgggattatcgccgttattggacatacacttattccaacaggtgacttggcaactatt atcattgcggcagtcatgcctattgttcctggtgtattaataacaaacgcaatacaagat ttatttggtggacacatgttgatgttcacaacgaaatcattagaagcattggttactgcg tttggcatcggtgctggcgttggtagcgtattaattttagta 36. gtgattgctataatgaatgtaattatcgatgaaagaaaagagaatgctatgacatttaat aaagtattattgagctggatagtcatattgattataacaactagcatatatctattttgg cagttgggcgatatcaatgatgtatttaaccagtctattttaatcaatgttagattaccg agattattagaagcattgttgacaggtatgatattaactgttgcaggccttatatttcaa acagttttaaataatgcattggcagatagctttacattaggat tggcaagcggcgctaca tttggttcaggattagcattatttttaggtttaacaacgttatggattcctgtattttca ataacatttagtttgataacattaataactgtattagtcattacgtcggtattgagccaa ggctatccagttagaatcttaatattaagtggtttaatgattggtgcgttattcaattca cttctatattttttgattttattaaaacctcgcaaattaaatacaattgccaattatctg tttggtggttttggtgatgcagaatactcaaatgtatctataatagcaatcacatttatc attgcattgtttggtatatttatcattcttaatcaactaaagttattgcaattaggagaa ctaaaaagtcagtcactaggcttaaatgttcaattgattacatatatcgcgttatgtata gcttctatgataacggcgataaatgtcgcatatgttggcatcattggattcattggtatg gtgataccgcaactcattagaaaatggcagtggaaacaatcattaggaagacaattggct ttaaatattgtaactggaggacaaataatggttatggcagattttattggtagccatata ttgtcaccagtacaaataccggcaagtattatcattgcattaattggtataccagtgtta ttttacatgctaatatctcagtcgaaacggttacac 37. ttgaaaaaattagcatttgcaataacagcaacatctggtgcagctgcatttttaacgcat catgatgcacaagcttctacacaacatacagtacaatctggtgaatcattatggagtatt gctcaaaaatacaacacttcagtagagagtattaaacaaaataaccaattagataacaac ttggtattccctggtcaagttatctcagtaggtggaagtgatgcacaaaatacgtcaaac acttctccacaagctggttcagcatc atctcatactgtacaagctggtgaatcattaaat atcattgctagcagatatggtgtttcagttgatcaattaatggcagccaataacttacgt ggttatttaattatgcctaaccaaacattacaaattcctaatggtggatcaggtggtaca acaccaacagctacaacaggtagcaatggcaatgcatcatcttttaatcaccaaaattta tacactgctggtcaatgtacatggtacgtatttgaccgtcgtgctcaagctggtagtcca attagcacatattggtcagacgctaagtattgggctggtaacgcagctaatgatggttac caagtaaacaacacaccatcagttggttcaattatgcaaagcacacctggtccatatggt catgttgcttatgttgaacgtgtcaatggtgatggtagtatcttgatttctgaaatgaat tacacatatggtccatacaatatgaactaccgtacaattccagcttcagaagtttctagc tatgcattcatccat 38. atgccagattcaatcacaattatagatgaaaacaaagtgattgatgttgtattaattgca ggtagaattttacttgaatcaggtgctgaaacatatcgagttgaagatacaatgaaccgt atcgcacatagttatggtcttcataatacatatagttttgtcagttcaactgcaattatt ttttcattaaacgatcgaacaagtacaagattaattcgtgtacaagagcgtacaacagat ttagagaaaatcgctttaacgaatagtctttcacgtaaaatatcaaataaagaactcaca attgatgaagctaaatctgaatttattcatttacagcatgcatcattacaatattctttt ttaacgaatttctttgcagctgccattgcatgtggcttcttcctatttatgtttggtggt gtcgcatcagattgttggattgcagtcatt gctggcggatccgcatttttaacattcagc tttgtgcaacgctatatacaaattaaatttttctcagagtttgttgcagccgctgtggtc atatccattgcagccacatttactaaattaggcattgcaaccaatcaagatatcattact atagccagtgtcatgccacttgtccctggtatattaattaccaatgccattcgagattta ttagcgggtgaattacttgcaggtatgtctcgcggtgttgaagctgcattaacagcattc gcaatcggtgctggtgtcgcaatcgttttattaatcatt 39. atgggatttttatcaaaaattcttgatggcaataataaagaaattaaacagttaggtaaa cttgctgataaagtaatcgctttagaagaaaaaacggcaattttaactgatgaagaaatt cgtaataaaacgaaacaattccaaacagaattagctgacattgataatgtcaaaaagcaa aatgattatttagataaaattttaccagaagcatatgcacttgttagagaaggctctaaa cgtgtattcaatatgacaccatataaagttcaaattatgggtggtattgcaattcataaa ggtgatatcgctgagatgagaacaggtgaaggtaaaacattaacagcgacaatgccaaca tacttaaatgcattagctggtagaggtgttcacgttattacagtcaatgaatacttatca agtgttcaaagtgaagaaatggctgagttatataacttcttaggtttgactgtcggatta aacttaaacagtaagacgacagaagaaaaacgtgaagcatacgcacaagacattacttac agtactaataatgagctaggttttgattacttacgagataacatggtgaattattctgaa gatagagtaatgcgtccattacattttgcaatcattgatgaggttgactcaattttaatc gacgaggcac gtacgccattaattatttctggtgaagctgaaaagtcaacgtcactttat acacaagcaaatgtttttgcgaaaatgttaaaacaggacgaagattataaatacgatgaa aaaacgaaagctgtacatttaacagaacaaggtgcggataaagctgaacgtatgttcaaa gttgaaaacttatatgatgtacaaaatgttgatgttattagtcatatcaacacagcttta cgtgcgcacgttacattacaacgtgacgtagactatatggttgttgatggcgaagtatta attgtcgatcaatttacaggacgtacaatgccaggccgtcgtttctcggaaggtttacac caagctattgaagcgaaggaaggcgttcaaattcaaaatgaatctaaaactatggcgtct attacattccaaaactatttcagaatgtacaataaacttgcgggtatgacaggtacagct aaaactgaagaagaagaatttagaaatatttataacatgacagtaactcaaattccgaca aataaacctgtgcaacgtaacgataagtctgatttaatttacattagccaaaaaggtaaa tttgatgcagtagtagaagatgttgttgaaaaacacaaggcagggcaaccagtgctatta ggtactgttgcagttgagacttctgaatatatttcaaatttacttaaaaaacgtggtatc cgtcatgatgtgttaaatgcgaaaaatcatgaacgtgaagctgaaattgttgcaggcgct ggacaaaaaggtgccgttactattgccactaacatggctggtcgtggtacagatatcaaa ttaggtgaaggcgtagaggaattaggcggtttagcagtaataggtacagagcgacatgaa tctcgtcgtattgatgaccagttacgtggtcgttctggacgtcaaggtgataaaggggat agtcgcttctatttatcattacaagatgaattaa tgattcgttttggttctgaacgttta cagaaaatgatgagccgactaggtttagatgactctacaccaattgaatcaaaaatggta tcaagagctgtagaatcagcacaaaaacgtgtagaaggtaataacttcgacgcgcgtaaa cgtatcttagaatacgatgaagtattacgtaaacaacgtgaaattatctataacgaaaga aatagtattattgatgaagaagacagctctcaagttgtagatgcaatgctacgttcaacg ttacaacgtagtatcaattactatattaatacagcagatgacgagcctgaatatcaacca ttcatcgactacattaatgacatcttcttacaagaaggtgacattacagaggatgatatc aaaggtaaagatgctgaagatattttcgaagtcgtttgggctaagattgaagcagcatat caaagtcaaaaagatatcttagaagaacaaatgaatgagtttgagcgtatgattttactt cgttctattgatagccattggactgatcatatcgacacaatggatcaattacgtcaaggt attcacttacgttcttatgcacaacaaaatccattacgtgactatcaaaatgaaggtcat gaattatttgatatcatgatgcaaaatattgaagaagatacttgtaaattcattttaaaa tctgtagtacaagttgaagataatattgaacgtgaaaaaacaacagagtttggtgaagcg aagcacgtttcagctgaagatggtaaagaaaaagtgaaaccgaaaccaatcgttaaaggc gatcaagttggtcgtaacgatgattgtccatgtggtagtggtaaaaaattcaaaaattgc catggaaaa 40. gtgagggagagtatgtcgaatcaaaattacgactacaataaaaatgaagatggaagtaag aagaaaatgagtacaacagcgaaagtagttagcattgcgacggt attgctattactcgga ggattagtatttgcaatttttgcatatgtagatcattcgaataaagctaaagaacgtatg ttgaacgaacaaaagcaggaacaaaaagaaaagcgtcaaaaagaaaatgcagaaaaagag agaaagaaaaagcaacaagaggaaaaagagcagaatgagctagattcacaagcaaaccaa tatcagcaattgccacagcagaatcaatatcaatatgtgccacctcagcaacaagcacct acaaagcaacgtcctgctaaagaagagaatgatgataaagcatcaaaggatgagtcgaaa gataaggatgacaaagcatctcaagataaatcagatgataatcagaagaaaactgatgat aataaacaaccagctcagcctaaaccacagccgcaacaaccaacaccaaagccaaataat aatcaacaaaacaatcaatcaaatcagcaagcaaaaccacaagcaccacaacaaaatagc caatcaacaacaaataaacaaaataatgctaatgataag 41. atgaatatgaagaaaaaagaaaaacacgcaattcggaaaaaatcgattggcgtggcttca gtgcttgtaggtacgttaatcggttttggactactcagcagtaaagaagcagatgcaagt gaaaatagtgttacgcaatctgatagcgcaagtaacgaaagcaaaagtaatgattcaagt agcgttagtgctgcacctaaaacagacgacacaaacgtgagtgatactaaaacatcgtca aacactaataatggcgaaacgagtgtggcgcaaaatccagcacaacaggaaacgacacaa tcatcatcaacaaatgcaactacggaagaaacgccggtaactggtgaagctactactacg acaacgaatcaagctaatacaccggcaacaactcaatcaagcaatacaaatgcggaggaa ttagtgaatcaaacaagtaatgaa acgacttctaatgatactaatacagtatcatctgta aattcacctcaaaattctacaaatgcggaaaatgtttcaacaacgcaagatacttcaact gaagcaacaccttcaaacaatgaatcagctccacagagtacagatgcaagtaataaagat gtagttaatcaagcggttaatacaagtgcgcctagaatgagagcatttagtttagcggca gtagctgcagatgcaccggcagctggcacagatattacgaatcagttgacgaatgtgaca gttggtattgactctggtacgactgtgtatccgcaccaagcaggttatgtcaaactgaat tatggtttttcagtgcctaattctgctgttaaaggtgacacattcaaaataactgtacct aaagaattaaacttaaatggtgtaacttcaactgctaaagtgccaccaattatggctgga gatcaagtattggcaaatggtgtaatcgatagtgatggtaatgttatttatacatttaca gactatgtaaatactaaagatgatgtaaaagcaactttgaccatgcccgcttatattgac cctgaaaatgttaaaaagacaggtaatgtgacattggctactggcataggtagtacaaca gcaaacaaaacagtattagtagattatgaaaaatatggtaagttttataacttatctatt aaaggtacaattgaccaaatcgataaaacaaataatacgtatcgtcagacaatttatgtc aatccaagtggagataacgttattgcgccggttttaacaggtaatttaaaaccaaatacg gatagtaatgcattaatagatcagcaaaatacaagtattaaagtatataaagtagataat gcagctgatttatctgaaagttactttgtgaatccagaaaactttgaggatgtcactaat agtgtgaatattacattcccaaatccaaatcaatataaagtagagttt aatacgcctgat gatcaaattacaacaccgtatatagtagttgttaatggtcatattgatccgaatagcaaa ggtgatttagctttacgttcaactttatatgggtataactcgaatataatttggcgctct atgtcatgggacaacgaagtagcatttaataacggatcaggttctggtgacggtatcgat aaaccagttgttcctgaacaacctgatgagcctggtgaaattgaaccaattccagaggat tcagattctgacccaggttcagattctggcagcgattctaattcagatagcggttcagat tcgggtagtgattctacatcagatagtggttcagattcagcgagtgattcagattcagca agtgattcagactcagcgagtgattcagattcagcaagcgattccgactcagcgagcgat tccgactcagacaatgactcggattcagatagcgattctgactcagacagtgactcagat tccgacagtgactcagattcagatagcgattctgactcagacagtgactcagattcagat agcgattcagattcagatagcgattcagattccgacagtgattccgactcagacagcgat tctgactccgacagtgattccgactcagacagcgattcagattccgacagtgattccgac tcagatagcgattccgactcagatagcgactcagattcagacagcgattcagattcagac agcgattcagattcagatagcgattcagattccgacagtgactcagattccgacagtgac tcggattcagatagcgattcagattccgacagtgactcagattccgacagtgactcagac tcagacagtgattcggattcagcgagtgattcggattcagatagtgattccgactccgac agtgactcggattcagatagcgactcagactcggatagcgactcggattcagatagcgat tcggactcaga tagcgattcagaatcagacagcgattcagaatcagacagcgattcagat tcagacagcgactcagacagtgactcagattcagatagtgactcggattcagcgagtgat tcagactcaggtagtgactccgattcatcaagtgattccgactcagaaagtgattcaaat agcgattccgagtcaggttctaacaataatgtagttccgcctaattcacctaaaaatggt actaatgcttctaataaaaatgaggctaaagatagtaaagaaccattaccagatacaggt tctgaagatgaagcaaatacgtcactaatttggggattattagcatcaataggttcatta ctacttttcagaagaaaaaaagaaaataaagataagaaa 42. atgaattcaaatcacgctaaagcatcagtgacagagagtgttgacaaaaaatttgtagtt ccagaatcaggaattaataaaattattccagcttacgatgaatttaagaattcgccaaaa gtaaatgttagtaatttaactgacaataaaaactttgtagcttctgaagataaattgaat aagattgcagattcatcggcagctagtaaaattgtagataaaaactttgtcgtaccagaa tcaaagttaggaaacattgtgccagagtacaaagaaatcaataatcgcgtgaatgtagca acaaacaatccagcttcacaacaagttgataagcattttgttgctaaaggcccagaagta aatagatttattacgcaaaacaaagtaaaccaccacttcattactacgcaaacccactac aagaaagttattacttcatacaaatcaacacatgtacataaacatgtaaatcatgcaaag gattctattaataaacactttattgttaaaccatcagaatcgcctagatatacacatcca tctcaatctttaattatcaagcatcattttgcagttcctggatatcacgcgc ataaattt gttacaccagggcatgctagcattaaaattaatcacttttgtgttgtgccacaaataaat agtttcaaggtaattccaccatatggtcacaattcacatcgtatgcatgtaccaagtttc caaaataacacaacagcaacacatcaaaatgctaaagtaaataaagcatatgactataaa tacttctattcttataaagtagttaaaggtgtgaagaaatatttctcattttcacaatca aatggttataaaattgggaaaccatcattaaatatcaaaaatgtaaattatcaatatgct gttccaagttatagccctacacactacgttcctgaatttaagggtagcttaccagcacca cgagta 43. ttggagcatacaattatgaaaatgagaacaattgctaaaaccagtttagcactagggctt ttaacaacaggcgcaattacagtaacgacgcaatcggtcaaagcagaaaaaatacaatca actaaagttgacaaagtaccaacgcttaaagcagagcgattagcaatgataaacataaca gcaggtgcaaattcagcgacaacacaagcagctaacacaagacaagaacgcacgcctaaa ctcgaaaaggcaccaaatactaatgaggaaaaaacctcagcttccaaaatagaaaaaata tcacaacctaaacaagaagagcagaaaacgcttaatatatcagcaacgccagcgcctaaa caagaacaatcacaaacgacaaccgaatccacaacgccgaaaactaaagtgacaacacct ccatcaacaaacacgccacaaccaatgcaatctactaaatcagacacaccacaatctcca accataaaacaagcacaaacagatatgactcctaaatatgaagatttaagagcgtattat acaaaaccgagttttgaatttgaaaagcagtttggatttatgctcaaaccatggacgacg gtta ggtttatgaatgttattccaaataggttcatctataaaatagctttagttggaaaa gatgagaaaaaatataaagatggaccttacgataatatcgatgtatttatcgttttagaa gacaataaatatcaattgaaaaaatattctgtcggtggcatcacgaagactaatagtaaa aaagttaatcacaaagtagaattaagcattactaaaaaagataatcaaggtatgatttca cgcgatgtttcagaatacatgattactaaggaagagatttccttgaaagagcttgatttt aaattgagaaaacaacttattgaaaaacataatctttacggtaacatgggttcaggaaca atcgttattaaaatgaaaaacggtgggaaatatacgtttgaattacacaaaaaactgcaa gagcatcgtatggcaggcactaatattgataacattgaagtgaatataaaa 44. atgacaacaattaaaacatcaaacttaggattcccaagattaggtagaaaaagagaatgg aaaaaagccatcgaaagttattgggcaaagaagatttctaaagaagaattagatcaaaca ttaactgatctacataaagaaaatttattattacaaaagtactatcacttagatagcatc ccagttggtgatttctctttatatgaccatatattagatacgtcattattattcaacatc atccctgaacgtttccaaggaagaactattgatgatgatttattatttgatattgctcgc ggtaataaagaccatgttgcaagtgcacttataaaatggtttaacactaactatcattac atcgtacctgaatgggacaatgttgagcctaaagtgagtcgcaatgtattattagatcgc tttaaatatgcccaatctttaaacgttaacgctcaccctgtcattgttggtccgattact tttgttaaattatcaaaaggcggtcaccaaact tttgaagaaaaagttaaaacgttatta ccactttataaagaagtgtttgaatcattaattgatgcaggtgctgagtacattcaagtt gatgagccaatcttagttacagacgacagcgaaagctatgaaaatattacacgtgaagct tatgactatttcgaaaaagctggtgttgctaaaaaattagtcattcaaacatactttgaa cgtgcacatcttaaattcttaagttctttacctgttggtggtataggtttagactttgtc catgataatggctataaccttaaacaaattgaagctggagattttgataaatcaaaaaca ttatacgctggaattattgatggtcgtaatgtatgggcaagtgacattgaagctaaaaaa gtcttaatcgataaattgttagcacacactaatgaacttgtcattcaaccatcatcttca ttattacatgttccagtatctttagatgatgaaacattagatacaagtgttggagaaggc ttaagctttgcaactgaaaaattagacgaattagatgcattgcgtcgcctatttaatcaa aacgatagtgttaaatatgataaattaaaagcacgttatgagcgtttccaaaatcaatca ttcaaaaacttagattatgatttcgaaagcgtgcgtacttcaagacaatcaccattcgcg caacgtattgaacaacaacaaaaacgtttgaacttaccggatttaccaacaacaactatt ggatcattcccacaaagccgagaagttcgaaaataccgtgcagattggaagaacaaacgc attacagacgaagcatatgaaacattcttaaaaaatgaaattgctcgatggattaaaatt caagaagacattggcttagatgtattagttcacggtgaatttgaacgtaatgacatggtt gaattcttcggagaaaaattacaaggtttcttagtaactaaattcggttgggtgcaa tca tatggttcacgtgccgtaaaaccaccaatcatttatggtgatgtaaaatggacagcgcct ttaactgttgatgaaacagtttatgcacaaagcttaacagataaaccagttaaaggtatg ttaactggacctgtaacaattctaaactggtcatttgaacgtgttgatttaccacgtaaa gtcgttcaagatcaaattgctttagcaatcaacgaagaagtattagcacttgaagctgca ggaatcaaagttatccaagttgacgaacctgcattacgtgaaggcttaccattacgctct gaatatcacgaacaatatcttaaagatgctgttttatcatttaaacttgcaacgtcttca gttcgtgatgaaactcaaatccatacacatatgtgttattctcaattcggtcaaatcatt catgctattcatgacttagatgctgatgttatttcaattgaaacatctcgtagccatggt gatttaattaaagactttgaagatattaattatgatttaggtattggtctaggtgtatat gatattcatagtccacgtattccaacaaaagaagaaattactacagcaatcaatcgttca ctacaacaaatcgaccgctcattattctgggtaaaccctgactgtggtttaaaaacgcga aaagaagaagaagttaaagatgcattgactgtgcttgtgaatgctgttaaagctaaacgc caagaa 45. atgagcgacacatataaaagctacctagtagcagtactatgcttcacagtcttagcaatt gtacttatgccgtttctatacttcactacagcatggtcaattgcgggattcgcaagtatc gcaacattcatattttataaagaatacttttatgaagaa 46. atgttaagaggacaagaagaaagaaagtatagtattagaaagtattcaataggcgtggtg tcagtgttagcggctacaatgtttgt tgtgtcatcacatgaagcacaagcctcggaaaaa acatcaactaatgcagcggcacaaaaagaaacactaaatcaaccgggagaacaagggaat gcgataacgtcacatcaaatgcagtcaggaaagcaattagacgatatgcataaagagaat ggtaaaagtggaacagtgacagaaggtaaagatacgcttcaatcatcgaagcatcaatca acacaaaatagtaaaacaatcagaacgcaaaatgataatcaagtaaagcaagattctgaa cgacaaggttctaaacagtcacaccaaaataatgcgactaataatactgaacgtcaaaat gatcaggttcaaaatacccatcatgctgaacgtaatggatcacaatcgacaacgtcacaa tcgaatgatgttgataaatcacaaccatccattccggcacaaaaggtaatacccaatcat gataaagcagcaccaacttcaactacacccccgtctaatgataaaactgcacctaaatca acaaaagcacaagatgcaaccacggacaaacatccaaatcaacaagatacacatcaacct gcgcatcaaatcatagatgcaaagcaagatgatactgttcgccaaagtgaacagaaacca caagttggcgatttaagtaaacatatcgatggtcaaaattccccagagaaaccgacagat aaaaatactgataataaacaactaatcaaagatgcgcttcaagcgcctaaaacacgttcg actacaaatgcagcagcagatgctaaaaaggttcgaccacttaaagcgaatcaagtacaa ccacttaacaaatatccagttgtttttgtacatggatttttaggattagtaggcgataat gcacctgctttatatccaaattattggggtggaaataaatttaaagttatcgaagaattg agaaagcaaggctataatgtacatcaagcaagtgtaagtgcatttggtag taactatgat cgcgctgtagaactttattattacattaaaggtggtcgcgtagattatggcgcagcacat gcagctaaatacggacatgagcgctatggtaagacttataaaggaatcatgcctaattgg gaacctggtaaaaaggtacatcttgtagggcatagtatgggtggtcaaacaattcgttta atggaagagtttttaagaaatggtaacaaagaagaaattgcctatcataaagcgcatggt ggagaaatatcaccattattcactggtggtcataacaatatggttgcatcaatcacaaca ttagcaacaccacataatggttcacaagcagctgataagtttggaaatacagaagctgtt agaaaaatcatgttcgctttaaatcgatttatgggtaacaagtattcgaatatcgattta ggattaacgcaatggggctttaaacaattaccaaatgagagttacattgactatataaaa cgcgttagtaaaagcaaaatttggacatcagacgacaatgctgcctatgatttaacgtta gatggctctgcaaaattgaacaacatgacaagtatgaatcctaatattacgtatacgact tatacaggtgtatcatctcatactggtccattaggttatgaaaatcctgatttaggtaca tttttcttaatggctacaacgagtagaattattggtcatgatgcaagagaagaatggcgt aaaaatgatggtgtcgtaccagtgatttcgtcattacatccgtccaatcaaccatttgtt aatgttacgaatgatgaacctgccacacgcagaggtatctggcaagttaaaccaatcata caaggatgggat 47. atgattcatctcattaaggggaagatgcatcatacagttttgtgtattcatttaaacaaa ggggttgctttaatgaatcaatatcattctaatgcacaacaaccaagtgcatggcgt ttt tttgtctatagtttagtgggcatactatgtttctttattccttttacgattaatggtaac aacactattttcgtcgatcatgttcatctagccattcgctcaatcataggtccacttatg ccctatgttgcactgattatgattttaattggtacagcgttaccaatagtgagacgtact tttatgacttcaatcacaaacttggtcattacattatttaaagttgcaggtgcaatgatc ggtataatgtatgtatttaaaatcggtccatcaatactatttaaagctaactatggtccg tttttgtttgaaaaattaatgatgccattaagtatcttaattccagtaggtgcaattgcg ctttctttattagtgggctatggcttattagaatttgtcggtgtttatatggagcctatt atgagacctatttttaaaacaccaggaaaatccgctgtcgatgcagtggcttcgtttgtc ggcagttattccttaggattattgattactaatcgtgtctataagcaagggatgtacaac aaacgagaagccacgattattgcgactggcttttcaacagtttcagcaacttttatgatt atcgttgctaaaactttaggattaatgccgcattggaatttatacttttggataacttta gtcatcacatttgtcgtgactgcaattactgcatggctaccgccaatcagcaatgaatca acagaatattataacggacaagaaggagaacaagaagttgctattgaaggaagcagactg aaaactgcatatgcagaggcgatgaaacaaaatgcattaacaccatctctcgtgaagaac gtttgggacaatttgaaagacggtttagaaatgactgttggtattttaccttctatatta tcgattggttttttaggactgattgtagcgaactatacaccattcattgattggcttggc tatatcttctatccatttat ttatattttcccaattgctgatcaggctttactagcaaaa gcgtcagcgatttctattgtagagatgtttctaccatctttgttagtaactaaagctgca atgagtactaaatttgtcgtcggtgtagtaagcgtatcagccattatctttttctcagca ttagtgccatgtatactagcaactgaaattaaaatacctgtctggaaactcatcatcatt tggtttttacgcgtggcgttgtcgctattaatcaccatccccgtcgctttacttattttt gga 48. atggttattatgaagaaaacaattttactgacgatgacaactcttactttatttagtatg tcgcctaactcggctcaagcatatacgaatgatagcaaaacattagaagaagcaaagaaa gcacacccaaacgcacagttcaaagtgaataaagacaccggcgcgtatacttatacatat gacaaaaacaacacgccaaacaacaatcatcaaaaccagtcacgtacaaacgacaatcat caacacgcaaatcaacgtgatcttaacaacaatcagtaccattcttcattaagtggtcag tatacgcacattaatgacgcaattgattcacacacaccgcctcaaacgtcaccaagcaat cctttgacaccagcaataccgaatgtcgaagacaatgacgatgaattaaataacgctttt tcaaaagataacaaagggcttattacaggcatcgatttagacgaattgtatgacgaatta caaatcgccgaatttaatgacaaagcaaagaccgctgacggtaaacctttagcattaggt aacggtaaaatcattgatcagcctcttatcacaagtaagaacaacttatatactgctgga caatgtacatggtatgtctttgataaacgtgccaaagatggacacacgattagtacattt tggggagatgctaaaaactgggcaggccaagcttca agcaatggcttcaaagtagataga cacccaacacgaggatcaattttacaaacagtaaatggtccatttggtcatgtagcctac gttgaaaaagttaatattgatggaagtattctaatttcagaaatgaactggattggtgaa tatatcgtttcatcaagaaccatctctgcttcagaagtttcatcatataattacatccat 49. ttggaggtatcgtcaatgaagccttatatacaacttgttgtgttcaagcaatggttacaa tacatcttgctcgtaacaaccattgtcatcgcactcgtacttattggtatcggttaccgt gtagcacatgacaacttcaaaataccgattaccattcaagatttagaccaaaccactgca tcaaaatcattcgtcaataaaattaaacaatctgactatgtaactattaaaaaagtcgat gaagatgaaagctatattgaagatgatgttactaaaaaggaagctattttaagtatgcaa attcctaaaggtttctctcaaaaattaaaagagaaccgtttaaaagaaacgatacagtta tatggtagagatgactttataggtggtattgctgtagaaattgttagtagttcattatat gagcagcaaattcctaacattatttatgaacaccttgaggatatgaaacagcatcaatcc atcgatgctatcaacaagtcctatcataaacatacacctgaatctaaaatcaaatttgtg tcgcttactaaacaagcacaacactctatttcaattagcttaatctttgcggtgatttta tttgttagcgctgttcaagtagtacttcattatcgtttaaaccaacaagcagcattgcaa cgattatcacaatatcatttaagccgtttcaaactatatagtacttatgtaatgacacat acgattttgttattgttggtactattggcagttagtctatatttgtctcaaccact cagc ttaatattttacttaaaatcactgttacttatattgatttatgagataggtatcgtcttt atcttattccatattcaaacaataagtcatcgattattcatgacatttatatatgcactt gctatgggtatcgtatacttgattattttcatg 50. atgattgaggtgacagagatgaacttttttgatatccataagattccgaacaaaggcatt ccattatcggtacaacgtaaattatggcttagaaacttcatgcaagctttcttcgtagtg ttctttgtttatatggctatgtatttaattcgaaacaactttaaggcggcacaaccgttt ttaaaagaggaaattggattatctacattagaacttggttatatcggattagcatttagt atcacgtacggtttaggaaaaacattacttggatattttgtcgatggacgtaacacaaaa cgtattatctcgttcttacttatcttatctgcgattacagttttaattatgggatttgtt ttaagttactttggttctgtaatgggattattaattgtactttggggacttaacggggtg ttccaatcagttggtggacctgcaagttattcaacgatttcaagatgggcgccaagaacg aaacgtggccgatacttaggattctggaatacatcacataatatcggtggtgccatagca ggtggtgttgcactttggggtgctaatgtattcttccatggaaatgttatagggatgttc attttcccatcggtgattgcattacttattggtatcgcaacattatttatcggaaaagat gatccggaagaattaggatggaatcgtgctgaagaaatttgggaagagccggtcgataaa gaaaatattgattctcaaggtatgacgaaatgggagatctttaaaaaatatatcctggga aatcctgttatatggattctatgtgtttcaaacgtctttgta tacattgtacgaatcggt attgataactgggcaccgttatatgtgtcagagcatttacactttagtaaaggcgatgca gttaatacgatattctactttgaaattggtgcattagttgcaagtttattatggggctac gtatcagacttattaaaaggtcgtcgtgcaattgtagctattggctgtatgtttatgatt acatttgttgtcttattctacacaaatgctacaagtgtcatgatggttaacatttcattg tttgcattaggtgcgttaatctttggtccgcaattattaattggtgtatcattgactggt tttgttcctaaaaatgccatcagtgtagcaaacggaatgacaggttcattcgcgtatcta ttcggtgactcaatggcgaaagttggtttggcggctattgctgatccaacacgtaacggt ttaaacatctttggatatacattaagtggatggacagatgttttcatcgtcttctatgtt gcattattcctaggcatgattctattaggaatcgttgctttctatgaagaaaagaaaatt agaagtttaaaaatt 51. atgacaaagaagaaaaacatattaaaagcaatcggtatttacagttttatagcgatgatg tttgtcatcattttatatccactactgtggacatttggcatttcccttaatccaggtacg aacttgtatggtgccaaaatgataccagacaatgcaacatttaaaaattatgcattctta ctattcgatgacagtagtcaatacctgacttggtataaaaatacgcttatcgtagcatct gcaaatgcactgtttagtgtgatatttgtcacgttaacagcatatgctttttctagatat cgctttgttggtcgtaaatacgggctgattacatttttgattttacaaatgttccctgta ttaatggcaatggtcgcaatctatattttgctaaatacaattggat tattagattcttta tttggactaacactggtatatattggtggatcaataccgatgaatgcctttttagtgaaa ggttacttcgatacgattccaaaagaacttgatgaatctgccaaaattgatggtgcaggg catatgcgtattttcttacaaattatgcttccattagctaagccgattttagcagttgtt gctttgttcaattttatggggccatttatggactttatattacctaaaatactattaaga agtcctgaaaaattcacattagcagttggattgttcaactttattaatgataagtatgca aataatttcacagtgtttgcagcaggggcaattatgattgcagtacctatagcaatcgta ttcttgttcttgcaacgctatttagtatcaggtttaacaacaggtgcgacaaaaggt 52. gtgatggaaaatagtacgaccgaagcgcgtaatgaagcgacgatgcatcttgatgaaatg actgtggaagaggctttaattacgatgaataaagaagatcagcaagtcccgttagcagtt cgaaaggcaataccacaattgacaaaagtaattaaaaaaacaattgcacagtataaaaag ggtggacgattgatttatatcggtgcaggtacaagtggaaggttgggtgtcttagatgca gcggagtgtgtacctacattcaatactgaccctcatgaaattataggtattattgctggt ggacaacatgctatgacgatggctgtagaaggtgcggaagatcacaaaaaattagcggaa gaagatttgaaaaatatagatttaacatcaaaagatgtcgttataggaattgccgcgagt ggcaaaacgccatatgttataggcggtttaacatttgctaacacaatcggtgctacaaca gtatctatttcatgcaatgaacatgcagttataagtgaaattgcgcagtatccagtagaa gttaaagt tggtccagaagtattaactggttcaacacgtttaaagtctggtacagcacaa aagttaattttaaatatgatttcaaccatcacaatggttggtgtcggaaaagtttacgat aacctcatgattgatgttaaagcaaccaatcaaaaactgatcgaccgttcagtgcgtatt attcaagaaatatgtgctatcacatatgatgaagcaatggcgttatatcaggtatctgag catgatgtgaaagttgcgacagttatgggtatgtgtggcatttctaaggaagaagcaaca agacggttattaaacaatggtgacattgttaaacgagcaatcagagatagacaacct 53. ttgcaatacataattcgttatattatgatgactttacaaatacatacagggggtattaat ttgaaaaagaaaaacatttattcaattcgtaaactaggtgtaggtattgcatctgtaact ttaggtacattacttatatctggtggcgtaacacctgctgcaaatgctgcgcaacacgat gaagctcaacaaaatgctttttatcaagtcttaaatatgcctaacttaaatgctgatcaa cgcaatggttttatccaaagccttaaagatgatccaagccaaagtgctaacgttttaggt gaagctcaaaaacttaatgactctcaagctccaaaagctgatgcgcaacaaaataacttc aacaaagatcaacaaagcgccttctatgaaatcttgaacatgcctaacttaaacgaagcg caacgtaacggcttcattcaaagtcttaaagacgacccaagccaaagcactaacgtttta ggtgaagctaaaaaattaaacgaatctcaagcaccgaaagctgataacaatttcaacaaa gaacaacaaaatgctttctatgaaatcttgaatatgcctaacttaaacgaagaacaacgc aatggtttcatccaaagcttaaaagatgacc caagccaaagtgctaacctattgtcagaa gctaaaaagttaaatgaatctcaagcaccgaaagcggataacaaattcaacaaagaacaa caaaatgctttctatgaaatcttacatttacctaacttaaacgaagaacaacgcaatggt ttcatccaaagcctaaaagatgacccaagccaaagcgctaaccttttagcagaagctaaa aagctaaatgatgctcaagcaccaaaagctgacaacaaattcaacaaagaacaacaaaat gctttctatgaaattttacatttacctaacttaactgaagaacaacgtaacggcttcatc caaagccttaaagacgatccttcagtgagcaaagaaattttagcagaagctaaaaagcta aacgatgctcaagcaccaaaagaggaagacaataacaagcctggcaaagaagacaataac aagcctggcaaagaagacaacaacaagcctggtaaagaagacaacaacaagcctggcaaa gaagacggcaacaagcctggtaaagaagacaacaaaaaacctggtaaagaagatggcaac aagcctggtaaagaagacaacaaaaaacctggtaaagaagacggcaacaagcctggcaaa gaagatggcaacaaacctggtaaagaagatggtaacggagtacatgtcgttaaacctggt gatacagtaaatgacattgcaaaagcaaacggcactactgctgacaaaattgctgcagat aacaaattagctgataaaaacatgatcaaacctggtcaagaacttgttgttgataagaag caaccagcaaaccatgcagatgctaacaaagctcaagcattaccagaaactggtgaagaa aatccattcatcggtacaactgtatttggtggattatcattagccttaggtgcagcgtta ttagctggacgtcgtcgcgaacta 54. ttggataaaaagtctgagaagcgggg cattaaaatgacggtacaaagtgcatatatacat attccattttgtgtaagaatatgtacatattgtgatttcaataaatattttatacagaat caacctgtagatgagtacttagatgcactaatcacagaaatgtctacagcaaaatatagg atcttaaagaccatgtatgtaggtggcggcacaccaacggccctttctattaatcagttg gaaagattacttaaagcaatacgtgatacgtttacaatcacaggcgagtatacatttgaa gcaaatcctgatgagttaactaaagagaaagtccaactattagagaaatatggagtaaaa aggatttcaatgggcgttcaaacattcaagccggagttattgtctgttttaggtagaacg cacaatactgaagatatttacacttcggtgttaaatgctaaaaacgcaggtattaaatca atcagtttagatttaatgtatcatttaccgaaacagacgattgaagattttgaacaaagt ttagatctagctttagatatggatattcaacatatttcgagttacggcttaatacttgaa cctaaaacccaattttataatatgtatagaaaaggcttgctcaaacttcctaatgaggat ttaggtgctgacatgtatcagttgctgatgtctaagatagaacaatctcctttccatcaa tacgaaatatctaattttgcattagatggccatgaatcagaacataataaggtttactgg tttaatgaggaatattatggatttggagcaggtgcaagtggttatgtagatggtgtgcgt tatacgaatatcaatccagtgaatcattatatcaaagctataaataaagaaagtaaagca attttagtatcaaataaaccttctttgactgagagaatggaagaagaaatgtttcttggg ttgcgtttaaatgaaggtgtgagtagtagtaggttcaaaaagaagtttga ccaatctatt gaaagtgtctttggtcaaacaataaataatttaaaagagaaggaattaattgtagaaaag aacgatgtgattgcacttacaaatagagggaaagtcataggtaatgaggtttttgaagct ttcctaataaatgat 55. MRNIENLNPGDSVDHFFLVHKATQGVTAQGKDYMTLHLQDKSGEIEAKFWTATKNDMATI KPEEIVHVKGDIINYRGNKQMKVNQIRLATTEDQLKTEQFVDGAPLSPAEIQEEISHYLL DIENANLQRITRHLLKKYQERFYTYPAASSHHHNFASGLSYHVLTMLRIAKSICDIYPLL NKSLLYSGIILHDIGKVRELSGPVATSYTVEGNLLGHISIASDEVVEAARELNIEGEEIM LLRHMILSHHGKLEYGSPKLPYLKEAEILCYIDNIDARMNMFEKAYKKTDKGQFTDKIFG LENRRFYNPESLD 56. MNKHHPKLRSFYSIRKSTLGVASVIVSTLFLITSQHQAQAAENTNTSDKISENQNNNATT TQPPKDTNQTQPATQPANTAKNYPAADESLKDAIKDPALENKEHDIGPREQVNFQLLDKN NETQYYHFFSIKDPADVYYTKKKAEVELDINTASTWKKFEVYENNQKLPVRLVSYSPVPE DHAYIRFPVSDGTQELKIVSSTQIDDGEETNYDYTKLVFAKPIYNDPSLVKSDTNDAVVT NDQSSSVASNQTNTNTSNQNTSTINNANNQPQATTNMSQPAQPKSSTNADQASSQPAHET NSNGNTNDKTNESSNQSDVNQQYPPADESLQDAIKNPAIIDKEHTADNWRPIDFQMKNDK GERQFYHYASTVEPATVIFTKTGPIIELGLKTASTWKKFEVYEGDKKLPVELVSYDSDKD YAYIRFPVSNGTREVKIVSSIEYGENIHEDYDYTLMVFAQPITNNPDDYVDEETYNLQKL LAPYHKAKTLERQVYELEKLQEKLPEKYKAEYKKKL DQTRVELADQVKSAVTEFENVTPT NDQLTDLQEAHFVVFESEENSESVMDGFVEHPFYTATLNGQKYVVMKTKDDSYWKDLIVE GKRVTTVSKDPKNNSRTLIFPYIPDKAVYNAIVKVVVANIGYEGQYHVRIINQDINTKDD DTSQNNTSEPLNVQTGQEGKVADTDVAENSSTATNPKDASDKADVIEPESDVVKDADNNI DKDVQHDVDHLSDMSDNNHFDKYDLKEMDTQIAKDTDRNVDKDADNSVGMSSNVDTDKDS NKNKDKVIQLNHIADKNNHTGKAAKLDVVKQNYNNTDKVTDKKTTEHLPSDIHKTVDKTV KTKEKAGTPSKENKLSQSKMLPKTGETTSSQSWWGLYALLGMLALFIPKFRKESK 57. Msdfnhtdhsttnhsqtpryrrpkfpwfktvivaliagiigallvlgigkvlnstilnkd Gstvqttnnkggnqldgqskkfgtvhemiksvsptivgvinmqkassvddllkgksskps Eagvgsgviyqinnnsayivtnnhvidganeirvqlhnkkqvkaklvgkdavtdiavlki Entkgikaiqfansskvqtgdsvfamgnplglqfansvtsgiisasertidaettggntk Vsvlqtdaainpgnsggalvdingnlvginsmkiaatqvegigfaipsnevkvtieqlvk Hgkidrpsigiglinlkdipeeereqlhtdredgiyvakadsdidlkkgdiiteidgkki Kddvdlrsylyenkkpgesvtvtvirdgktkevkvklkqqkeqpkrqsrserqspgqgdr dffr 58. VNQQQEKTTTTPTTINPLTGEKVGEGEPTTEVTKEPVDEITQFGGEEVPQGHKDEFDPNL PIDGTEEVPGKPGIKNPETGEVVTPPVDDVTKHGPKAGEPEVTKEEIPFEKKREFNPDLK PGEEKVTQEGQTGEKTTTTPTTINPLTGEKVGEGEPTTEVTKEPVDEITQFG GEEVPQGH KDEFDPNLPIDGTEEVPGKPGIKNPETGEVVTPPVDDVTKHGPKAGEPEVTKEEIPYETK RVLDPTMEPGSPDKVAQKGENGEKTTTTPTTINPLTGEKVGEGEPTTEVTKEPIDEIVNY APEIIPHGTREEIDPNLPEGETKVIPGKDGLKDPETGEIIEEPQDEVIIHGAKDDSDADS DSDADSDSDADSDSDADSDSDADSDSDSDSDSDSDSDSDADSDSDADSDSDSDSDSDADS DSDADSDSDADSDSDADSDSDSDSDSDADSDSDSDSDSDADSDSDADSDSDADSDSDADS DSDSDSDSDADSDSDSDSDSDSDADSDSDSDSDADSDSDADSDSDADSDSDADSDSDSDS DSDSDSDSDSDSDRDSDADSDSDADSDSDSDSDSDADSDSDSDSDSDADSDSDADSDSDS DADSDSDSDSDSDADSDSDADSDSDADSDSDADSDSDSDSDSDSDSDSDADSDSDADSDS DADRDHNDKTDKPNNKELPDTGNDAQNNGTLFGSLFAALGGLFLVGRRRKNKNNEEK 59. MKSLKTVIGMNNKEHIKSVILALLVLMSVVLTYMVWNFSPDIANVDNTDSKKSETKPLTT PMTAKMDTTITPFQIIHSKNDHPEGTIATVSNVNKLTKPLKNKEVKSVEHVRRDHNLMIP DLNSDFILFDFTYDLPLSTYLGQVLNMNAKVPNHFNFNRLVIDHDADDNIVLYAISKDRH DYVKLTTTTKNDHFLDALAAVKKDMQPYTDIITNKDTIDRTTHVFAPSKPEKLKTYRMVF NTISVEKMNAILFDDSTIVRSSKSGVTTYNNNTGVANYNDKNEKYHYKNLSEDEASSSKM EETIPGTFDFINGHGGFLNEDFRLFSTNNQSGELTYQRFLNGYPTFNKEGSNQIQVTWGE KGVFDYRRSLLRTDVVLNSEDNKSLPKLESVRSSLANNSDINFEKVTNIAIGYEMQDNSD HNHIEVQINSELVP RWYVEYDGEWYVYNDGRLE 60. MSKRQKAFHDSLANEKTRVRLYKSGKNWVKSGIKEIEMFKIMGLPFISHSLVSQDNQSIS KKMTGYGLKTTAVIGGAFTVNMLHDQQAFAASDAPLTSELNTQSETVGNQNSTTIEASTS TADSTSVTKNSSSVQTSNSDTVSSEKSEKVTSTTNSTSNQQEKLTSTSESTSSKNTTSSS DTKSVASTSSTEQPINTSTNQSTASNNTSQSTTPSSVNLNKTSTTSTSTAPVKLRTFSRL AMSTFASAATTTAVTANTITVNKDNLKQYMTTSGNATYDQSTGIVTLTQDAYSQKGAITL GTRIDSNKSFHFSGKVNLGNKYEGHGNGGDGIGFAFSPGVLGETGLNGAAVGIGGLSNAF GFKLDTYHNTSKPNSAAKANADPSNVAGGGAFGAFVTTDSYGVATTYTSSSTADNAAKLN VQPTNNTFQDFDINYNGDTKVMTVKYAGQTWTRNISDWIAKSGTTNFSLSMTASTGGATN LQQVQFGTFEYTESAVTQVRYVDVTTGKDIIPPKTYSGNVDQVVTIDNQQSALTAKGYNY TSVDSSYASTYNDTNKTVKMTNAGQSVTYYFTDVKAPTVTVGNQTIEVGKTMNPIVLTTT DNGTGTVTNTVTGLPSGLSYDSATNSIIGTPTKIGQSTVTVVSTDQANNKSTTTFTINVV DTTAPTVTPIGDQSSEVYSPISPIKIATQDNSGNAVTNTVTGLPSGLTFDSTNNTISGTP TNIGTSTISIVSTDASGNKTTTTFKYEVTRNSMSDSVSTSGSTQQSQSVSTSKADSQSAS TSTSGSIVVSTSASTSKSTSVSLSDSVSASKSLSTSESNSVSSSTSTSLVNSQSVSSSMS DSASKSTSLSDSISNSSSTEKSESLSTSTSDSLRTSTSLSDSLSMSTSGSLSKSQSLSTS ISGSSSTSASLSDSTSNAISTSTSLSESASTSDSISISNSIANSQSASTSKSDSQSTSIS LSTSDSKSMSTSESLSDSTSTSGSVSGSLSIAASQSVSTSTSDSMSTSEIVSDSISTSGS LSASDSKSMSVSSSMSTSQSGSTSESLSDSQSTSDSDSKSLSQSTSQSGSTSTSTSTSAS VRTSESQSTSGSMSASQSDSMSISTSFSDSTSDSKSASTASSESISQSASTSTSGSVSTS TSLSTSNSERTSTSMSDSTSLSTSESDSISESTSTSDSISEAISASESTFISLSESNSTS DSESQSASAFLSESLSESTSESTSESVSSSTSESTSLSDSTSESGSTSTSLSNSTSGSTS ISTSTSISESTSTFKSESVSTSLSMSTSTSLSDSTSLSTSLSDSTSDSKSDSLSTSMSTS DSISTSKSDSISTSTSLSGSTSESKSDSTSMSISMSQSTSGSTSTSTSTSLSDSTSTSLS LSASMNQSGVDSNSASQSASNSTSTSTSESDSQSTSSYTSQSTSQSESTSTSTSLSDSTS ISKSTSQSGSVSTSASLSGSESESDSQSISTSASESTSESASTSLSDSTSTSNSGSASTS TSLSNSASASESDLSSTSLSDSTSASMQSSESDSQSTSASLSDSLSTSTSNRMSTIASLS TSVSTSESGSTSESTSESDSTSTSLSDSQSTSRSTSASGSASTSTSTSDSRSTSASTSTS MRTSTSDSQSMSLSTSTSTSMSDSTSLSDSVSDSTSDSTSASTSGSMSVSISLSDSTSTS TSASEVMSASISDSQSMSESVNDSESVSESNSESDSKSMSGSTSVSDSGSLSVSTSLRKS ESVSESSSLSCSQSMSDSVSTSDSSSLSVSTSLRSSESVSESDSLSDSKSTSGSTSTSTS GSLSTSTSLSGSESVSESTSLSDSISMSDSTSTSDSDSLSGSISLSGSTSLSTSDSLSDS KSLSSSQSMSGSESTSTSVSDSQSSSTSNSQFDSMSISASESDSMSTSDSSSISGSNSTS TSLSTSDSMSGSVSVSTSTSLSDS ISGSTSVSDSSSTSTSTSLSDSMSQSQSTSTSASGS LSTSISTSMSMSASTSSSQSTSVSTSLSTSDSISDSTSISISGSQSTVESESTSDSTSIS DSESLSTSDSDSTSTSTSDSTSGSTSTSISESLSTSGSGSTSVSDSTSMSESNSSSVSMS QDKSDSTSISDSESVSTSTSTSLSTSDSTSTSESLSTSMSGSQSISDSTSTSMSGSTSTS ESNSMHPSDSMSMHHTHSTSTSRLSSEATTSTSESQSTLSATSEVTKHNGTPAQSEKRLP DTGDSIKQNGLLGGVMTLLVGLGLMKRKKKKDENDQDDSQA 61. MPKNKILIYLLSTTLVLPTLVSPTAYADTPQKDTTAKTTSHDSKKSNDDETSKDTTSKDI DKADKNNTSNQDNNDKKFKTIDDSTSDSNNIIDFIYKNLPQTNINQLLTKNKYDDNYSLT TLIQNLFNLNSDISDYEQPRNGEKSTNDSNKNSDNSIKNDTDTQSSKQDKADNQKAPKSN NTKPSTSNKQPNSPKPTQPNQSNSQPASDDKANQKSSSKDNQSMSDSALDSILDQYSEDA KKTQKDYASQSKKDKNEKSNTKNPQLPTQDELKHKSKPAQSFNNDVNQKDTRATSLFETD PSISNNDDSGQFNVVDSKDTRQFVKSIAKDAHRIGQDNDIYASVMIAQAILESDSGRSAL AKSPNHNLFGIKGAFEGNSVPFNTLEADGNQLYSINAGFRKYPSTKESLKDYSDLIKNGI DGNRTIYKPTWKSEADSYKDATSHLSKTYATDPNYAKKLNSIIKHYQLTQFDDERMPDLD KYERSIKDYDDSSDEFKPFREVSDSMPYPHGQCTWYVYNRMKQFGTSISGDLGDAHNWNN RAQYRDYQVSHTPKRHAAVVFEAGQFGADQHYGHVAFVEKVNSDGSIVISESNVKGLGII SHRTINAAAAEELSYITGK 62. MRKFSRYAFTSMAALTLLSTLSPAALAIDSKNKPANSDI KFEVTQKSDAVKALKELPKSE NVKNIYQDYAVTDVKTDKKGFTHYTLQPSVDGVHAPDKEVKVHADKSGKVVLINGDTDAK KVKPTNKVTLSKDDAADKAFKAVKIDKNKAKNLKDKVIKENKVEIDGDSNKYVYNVELIT VTPEISHWKVKIDAQTGEILEKMNLVKEAAETGKGKGVLGDTKDININSIDGGFSLEDLT HQGKLSAFSFNDQTGQATLITNEDENFVKDEQRAGVDANYYAKQTYDYYKDTFGRESYDN QGSPIVSLTHVNNYGGQDNRNNAAWIGDKMIYGDGDGRTFTSLSGANDVVAHELTHGVTQ ETANLEYKDQSGALNESFSDVFGYFVDDEDFLMGEDVYTPGKEGDALRSMSNPEQFGQPA HMKDYVFTEKDNGGVHTNSGIPNKAAYNVIQAIGKSKSEQIYYRALTEYLTSNSNFKDCK DALYQAAKDLYDEQTAEQVYEAWNEVGVE 63. MKKRIDYLSNKQNKYSIRRFTVGTTSVIVGATILFGIGNHQAQASEQSNDTTQSSKNNAS ADSEKNNMIETPQLNTTANDTSDISANTNSANVDSTTKPMSTQTSNTTTTEPASTNETPQ PTAIKNQATAAKMQDQTVPQEANSQVDNKTTNDANSIATNSELKNSQTLDLPQSSPQTIS NAQGTSKPSVRTRAVRSLAVAEPVVNAADAKGTNVNDKVTASNFKLEKTTFDPNQSGNTF MAANFTVTDKVKSGDYFTAKLPDSLTGNGDVDYSNSNNTMPIADIKSTNGDVVAKATYDI LTKTYTFVFTDYVNNKENINGQFSLPLFTDRAKAPKSGTYDANINIADEMFNNKITYNYS SPIAGIDKPNGANISSQIIGVDTASGQNTYKQTVFVNPKQRVLGNTWVYIKGYQDKIEES SGKVSATDTKLRIFEVNDTSKLSDSYYADPNDSNLKEVTDQFKNRIYYEHPNVASIKFGD ITKTYVVLVEGHYDNTGKNLKTQVIQENV DPVTNRDYSIFGWNNENVVRYGGGSADGDSA VNPKDPTPGPPVDPEPSPDPEPEPTPDPEPSPDPEPEPSPDPDPDSDSDSDSGSDSDSGS DSDSESDSDSDSDSDSDSDSDSESDSDSESDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS DSDSESDSDSESDSESDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS RVTPPNNEQKAPSNPKGEVNHSNKVSKQHKTDALPETGDKSENTNATLFGAMMALLGSLL LFRKRKQDHKEKA 64. MKKTIMASSLAVALGVTGYAAGTGHQAHAAEVNVDQAHLVDLAHNHQDQLNAAPIKDGAY DIHFVKDGFQYNFTSNGTTWSWSYEAANGQTAGFSNVAGADYTTSYNQGSNVQSVSYNAQ SSNSNVEAVSAPTYHNYSTSTTSSSVRLSNGNTAGATGSSAAQIMAQRTGVSASTWAAII ARESNGQVNAYNPSGASGLFQTMPGWGPTNTVDQQINAAVKAYKAQGLGAWGF 65. MGGYLIMKKIVTATIATAGLATIAFAGHDAQAAEQNNNGYNSNDAQSYSYTYTIDAQGNY HYTWTGNWNPSQLTQNNTYYYNNYNTYSYNNASYNNYYNHSYQYNNYTNNSQTATNNYYT GGSGASYSTTSNNVHVTTTAAPSSNGRSISNGYASGSNLYTSGQCTYYVFDRVGGKIGST WGNASNWANAAASSGYTVNNTPKVGAIMQTTQGYYGHVAYVEGVNSNGSVRVSEMNYGHG AGVVTSRTISANQAGSYNFIH 66. MANTKKTTLDITGMTCAACSNRIEKKLNKLDDVNAQVNLTTEKATVEYNPDQHDVQEFIN TIQHLGYGVAVE TVELDITGMTCAACSSRIEKVLNKMDGVQNATVNLTTEQAKVDYYPEE TDADKLVTRIQKLGYDASIKDNNKDQTSRKAEALQHKLIKLIISAVLSLPLLMLMFVHLF NMHIPALFTNPWFQFILATPVQFIIGWQFYVGAYKNLRNGGANMDVLVAVGTSAAYFYSI YEMVRWLNGSTTQPHLYFETSAVLITLILFGKYLEARAKSQTTNALGELLSLQAKEARIL KDGNEVMIPLNEVHVGDTLIVKPGEKIPVDGKIIKGMTAIDESMLTGESIPVEKNVDDTV IGSTMNKNGTITMTATKVGGDTALANIIKVVEEAQSSKAPIQRLADIISGYFVPIVVGIA LLTFIVWITLVTPGTFEPALVASISVLVIACPCALGLATPTSIMVGTGRAAENGILFKGG EFVERTHQIDTIVLDKTGTITNGRPVVTDYHGDNQTLQLLATAEKDSEHPLAEAIVNYAK EKQLILTETTTFKAVPGHGIEATIDHHHILVGNRKLMADNDISLPKHISDDLTHYERDGK TAMLIAVNYSLTGIIAVADTVKDHAKDAIKQLHDMGIEVAMLTGDNKNTAQAIAKQVGID TVIADILPEEKAAQIAKLQQQGKKVAMVGDGVNDAPALVKADIGIAIGTGTEVAIEAADI TILGGDLMLIPKAIYASKATIRNIRQNLFWAFGYNIAGIPIAALGLLAPWVAGAAMALSS VSVVTNALRLKKMRLEPRRKDA 67. MFDSIRETIDYAVENNMSFADIMVKEEMELSGKSRDEVRAQMKQNLDVMRDAVIKGTTGD GVESVTGYTGHDAAKLRDYNETHHALSGYEMIDAVKGAIATNEVNAAMGIICATPTAGSS GTIPGALFKLEKTHDLTEEQMIDFLFTSALFGRVVANNASVAGATGGCQAEVGSASAMAA AAAVAIFGGSPEASGHAMALAISNLLGLVCDPVAGLVEIPCVMRNAIGSGNALISADLAL AGIESRIPV DEVIEAMDKVGRNLPASLRETGLGGLAGTPTGEAIKRKIFGTAEDMVKNN 68. MKNNLRYGIRKHKLGAASVFLGTMIVVGMGQDKEAAASEQKTTTVEENGNSATDNKTSET QTTATNVNHIEETQSYNATVTEQPSNATQVTTEEAPKAVQAPQTAQPANIETVKEEVVKE EAKPQVKETTQSQDNSGDQRQVDLTPKKATQNQVAETQVEVAQPRTASESKPRVTRSADV AEAKEASNAKVETGTDVTSKVTVEIGSIEGHNNTNKVEPHAGQRAVLKYKLKFENGLHQG DYFDFTLSNNVNTHGVSTARKVPEIKNGSVVMATGEVLEGGKIRYTFTNDIEDKVDVTAE LEINLFIDPKTVQTNGNQTITSTLNEEQTSKELDVKYKDGIGNYYANLNGSIETFNKANN RFSHVAFIKPNNGKTTSVTVTGTLMKGSNQNGNQPKVRIFEYLGNNEDIAKSVYANTTDT SKFKEVTSNMSGNLNLQNNGSYSLNIENLDKTYVVHYDGEYLNGTDEVDFRTQMVGHPEQ LYKYYYDRGYTLTWDNGLVLYSNKANGNGKNGPIIQNNKFEYKEDTIKETLTGQYDKNLV TTVEEEYDSSTLDIDYHTAIDGGGGYVDGYIETIEETDSSAIDIDYHTAVDSEAGHVGGY TESSEESNPIDFEESTHENSKHHADVVEYEEDTNPGGGQVTTESNLVEFDEESTKGIVTG AVSDHTTVEDTKEYTTESNLIELVDELPEEHGQAQGPVEEITENNHHISHSGLGTENGHG NYDVIEEIEENSHVDIKSELGYEGGQNSGNQSFEEDTEEDKPKYEQGGNIVDIDFDSVPQ IHGQNKGNQSFEEDTEKDKPKYEHGGNIIDIDFDSVPHIHGFNKHTEIIEEDTNKDKPSY QFGGHNSVDFEEDTLPKVSGQNEGQQTIEEDTTPPIVPPTPPTPEVPSEPETPTPPTPEV PSEPETPTPPTPEVPSEPETPTPPTPEVPA EPGKPVPPAKEEPKKPSKPVEQGKVVTPVI EINEKVKAVAPTKKPQSKKSELPETGGEESTNKGMLFGGLFSILGLALLRRNKKNHKA 69. LHLRENIIVKSNLRYGIRKHKLGAASVFLGTMIVVGMGQEKEAAASEQNNTTVEESGSSA TESKASETQTTTNNVNTIDETQSYSATSTEQPSQSTQVTTEEAPKTVQAPKVETSRVDLP SEKVADKETTGTQVDIAQPSNVSEIKPRMKRSTDVTAVAEKEVVEETKATGTDVTNKVEV EEGSEIVGHKQDTNVVNPHNAERVTLKYKWKFGEGIKAGDYFDFTLSDNVETHGISTLRK VPEIKSTDGQVMATGEIIGERKVRYTFKEYVQEKKDLTAELSLNLFIDPTTVTQKGNQNV EVKLGETTVSKIFNIQYLGGVRDNWGVTANGRIDTLNKVDGKFSHFAYMKPNNQSLSSVT VTGQVTKGNKPGVNNPTVKVYKHIGSDDLAESVYAKLDDVSKFEDVTDNMSLDFDTNGGY SLNFNNLDQSKNYVIKYEGYYDSNASNLEFQTHLFGYYNYYYTSNLTWKNGVAFYSNNAQ GDGKDKLKEPIIEHSTPIELEFKSEPPVEKHELTGTIEESNDSKPIDFEYHTAVEGAEGH AEGTIETEEDSIHVDFEESTHENSKHHADVVEYEEDTNPGGGQVTTESNLVEFDEDSTKG IVTGAVSDHTTIEDTKEYTTESNLIELVDELPEEHGQAQGPIEEITENNHHISHSGLGTE NGHGNYGVIEEIEENSHVDIKSELGYEGGQNSGNQSFEEDTEEDKPKYEQGGNIVDIDFD SVPQIHGQNNGNQSFEEDTEKDKPKYEQGGNIIDIDFDSVPHIHGFNKHTEIIEEDTNKD KPNYQFGGHNSVDFEEDTLPQVSGHNEGQQTIEEDTTPPIVPPTPPTPEVPSEPETPTPP TPEVPSEPETPTPPTPEVPTEPGKPIPPAKEEPKKPSKPVEQGKVVTPVIEI NEKVKAVV PTKKAQSKKSELPETGGEESTNNGMLFGGLFSILGLALLRRNKKNHKA 70. MQMRDKKGPVNKRVDFLSNKLNKYSIRKFTVGTASILIGSLMYLGTQQEAEAAENNIENP TTLKDNVQSKEVKIEEVTNKDTAPQGVEAKSEVTSNKDTIEHEPSVKAEDISKKEDTPKE VADVAEVQPKSSVTHNAETPKVRKARSVDEGSFDITRDSKNVVESTPITIQGKEHFEGYG SVDIQKKPTDLGVSEVTRFNVGNESNGLIGALQLKNKIDFSKDFNFKVRVANNHQSNTTG ADGWGFLFSKGNAEEYLTNGGILGDKGLVNSGGFKIDTGYIYTSSMDKTEKQAGQGYRGY GAFVKNDSSGNSQMVGENIDKSKTNFLNYADNSTNTSDGKFHGQRLNDVILTYVASTGKM RAEYAGKTWETSITDLGLSKNQAYNFLITSSQRWGLNQGINANGWMRTDLKGSEFTFTPE APKTITELEKKVEEIPFKKERKFNPDLAPGTEKVTREGQKGEKTITTPTLKNPLTGVIIS KGEPKEEITKDPINELTEYGPETIAPGHRDEFDPKLPTGEKEEVPGKPGIKNPETGDVVR PPVDSVTKYGPVKGDSIVEKEEIPFXKERKFNPDLAPGTEKVTREGQKGEKTITTPTLKN PLTGEIISKGESKEEITKDPINELTEYGPETITPGHRDEFDPKLPTGEKEEVPGKPGIKN PETGDVVRPPVDSVTKYGPVKGDSIVEKEEIPFKKERKFNPDLAPGTEKVTREGQKGEKT ITTPTLKNPLTGEIISKGESKEEITKDPINELTEYGPETITPGHRDEFDPKLPTGEKEEV PGKPGIKNPETGDVVRPPVDSVTKYGPVKGDSIVEKEEIPFEKERKFNPDLAPGTEKVTR EGQKGEKTITTPTLKNPLTGEIISKGESKEEITKDPVNELTEFGGEKIPQGHKDIFDPNL PTDQTEKVPGKPGIKNPDTGKVI EEPVDDVIKHGPKTGTPETKTVEIPFETKREFNPKLQ PGEERVKQEGQPGSKTITTPITVNPLTGEKVGEGQPTEEITKQPVDKIVEFGGEKPKDPK GPENPEKPSRPTHPSGPVNPNNPGLSKDRAKPNGPVHSMDKNDKVKKSKIAKESVANQEK KRAELPKTGLESTQKGLIFSSIIGIAGLMLLARRRKN 71. MKNKYISKLLVGAATITLATMISNGEAKASENTQQTSTKHQTTQNNYVTDQQKAFYQVLH LKGITEEQRNQYIKTLREHPERAQEVFSESLKDSKNPDRRVAQQNAFYNVLKNDNLTEQE KNNYIAQIKENPDRSQQVWVESVQSSKAKERQNIENADKAIKDFQDNKAPHDKSAAYEAN SKLPKDLRDKNNRFVEKVSIEKAIVRHDERVKSANDAISKLNEKDSIENRRLAQREVNKA PMDVKEHLQKQLDALVAQKDAEKKVAPKVEAPQIQSPQIEKPKVESPKVEVPQIQSPKVE VPQSKLLGYYQSLKDSFNYGYKYLTDTYKSYKEKYDTAKYYYNTYYKYKGAIDQTVLTVL GSGSKSYIQPLKVDDKNGYLAKSYAQVRNYVTESINTGKVLYTFYQNPTLVKTAIKAQET ASSIKNTLSNLLSFWK 72. MAVFSKEKKRGCIVVIETFKAFVIDKDESGKVTPTFKQLSPTDLPKGDVLIKVHYSGINY KDALATQDHNAVVKSYPMIPGIDLAGTIVESEAPGFEKGEQVIVTSYDLGVSHYGGFSEY ARVKSEWIIKLPDTLTLEESMIYGTAGYTAGLAIERLEKVGMNIEDGPVLVRGASGGVGT LAVLMLNELGYKVIASTGKQDVSDQLLELGAKEVIDRLPVEDDHKKPLASSTWQACVDPV GGEGINYVTKRLNHSGSIAVIGMTAGNTYTNSVFPHILRGVNILGIDSVFTAMKLRQRVW RRLAKDLMPENLHEIKQVITFDELPEQLNKVIKHENKGRIVIDFG VDK 73. MKKLVTATTLTAGIGTALVGQAYHADAAENYTNYNNYNYNTTQTTTTTTTTTTTSSISHS GNLYTAGQCTWYVYDKVGGEIGSTWGNANNWAAAAQGAGFTVNHTPSKGAILQSSEGPFG HVAYVESVNSDGSVTISEMNYSGGPFSVSSRTISASEAGNYNYIHI 74. MKKIATATIATAGFATIAIASGNQAHASEQDNYGYNPNDPTSYSYTYTIDAQGNYHYTWK GNWHPSQLNQDNGYYSYYYYNGYNNYNNYNNGYSYNNYSRYNNYSNNNQSYNYNNYNSYN TNSYRTGGLGASYSTSSNNVQVTTTMAPSSNGRSISSGYTSGRNLYTSGQCTYYVFDRVG GKIGSTWGNASNWANAAARAGYTVNNTPKAGAIMQTTQGAYGHVAYVESVNSNGSVRVSE MNYGYGPGVVTSRTISASQAAGYNFIH 75. MSMTYRIKKWQKLSTITLLMAGVITLNGGEFRSVDKHQIAVADTNVQTPDYEKLRNTWLD VNYGYDKYDENNPDMKKKFDATEKEATNLLKEMKTESGRKYLWSGAETLETNSSHMTRTY RNIEKIAEAMRNPKTTLNTDENKKKVKDALEWLHKNAYGKEPDKKVKELSENFTKTTGKN TNLNWWDYEIGTPKSLTNTLILLNDQFSNEEKKKFTAPIKTFAPDSDKILSSVGKAELAK GGNLVDISKVKLLECIIEEDKDMMKKSIDSFNKVFTXVQDSATGKERNGFYKDGSYIDHQ DVPYTGAYGVVLLEGISQMMPMIKETPFNDKTQNDTTLKSWIDDGFMPLIYKGEMMDLSR GRAISRENETSHSASATVMKSLLRLSDAMDDSTKAKYKKIVKSSVESDSSYKQNDYLNSY SDIDKMKSLMTDNSISKNGLTQQLKIYNDMDRVTYHNKDLDFAFGLSMTSKNVARYESIN GENLKGWHTGAGMSYLYNSDVKHYHDNFWVTADMKRLSGTTTLDNEILKDTDDKK SSKTF VGGTKVDDQHASIGMDFENQDKTLTAKKSYFILNDKIVFLGTGIKSTDSSKNPVTTIENR KANGYTLYTDDKQTTNSDNQENNSVFLESTDTKKNIGYHFLNKPKITVKKESHTGKWKEI NKSQKDTQKTDEYYEVTQKHSNSDNKYGYVLYPGLSKDVFKTKKDEVTVVKQEDDFHVVK DNESVWAGVNYSNSTQTFDINNTKVEVKAKGMFILKKKDDNTYECSFYNPESTNSASDIE SKISMTGYSITNKNTSTSNESGVHFELTK 76. MNDLKQFLYIALVCGVIAGLGAFLHIPQYPSMTIPRIVAILGIISAMLTFKDKQISASLK FSALLINVLPLCGTFVASN 77. VSREMSYHWFKKMLLSTSILILSSSSLGLATHTVEAKDNLNGEKPTTNLNHNITSPSVNS EMNNNETGTPHESNQTGNEGTGSNSRDANPDSNNVKPDSNNQNPSTDSKPDPNNQNPSPN PKPDPDNPKPKPDPKPDPDKPKPNPDPKPDPDNPKPNPDPKPDPDKPKPNPDPKPDPDKP KPNPNPKPDPNKPNPNPSPDPDQPGDSNHSGGSKNGGTWNPNASDGSNQGQWQPNGNQGN SQNPTGNDFVSQRFLALANGAYKYNPYILNQINKLGKDYGEVTDEDIYNIIRKQNFSGNA YLNGLQQQSNYFRFQYFNPLKSERYYRNLDEQVLALITGEIGSMPDLKKPEDKPDSKQRS FEPHEKDDFTVVKKQEDNKKSASTAYSKSWLAIVCSMMVVFSIMLFLFVKRNKKKNKNES QRR 78. MKNKKRVLIASSLSCAILLLSAATTQANSAHKDSQDQNKKEHVDKSQQKDKRNVTNKDKN STAPDDIGKNGKITKRTETVYDEKTNILQNLQFDFIDDPTYDKNVLLVKKQGSIHSNLKF ESHKEEKNSNWLKYPSEYHVDFQVKRNRKTEILDQLPKNKISTAKVDSTFSYSSGGKFDS TKGIGRTSSNSYS KTISYNQQNYDTIASGKNNNWHVHWSVIANDLKYGGEVKNRNDELLF YRNTRIATVENPELSFASKYRYPALVRSGFNPEFLTYLSNEKSNEKTQFEVTYTRNQDIL KNRPGIHYAPPILEKNKDGQRLIVTYEVDWKNKTVKVVDKYSDDNKPYKEG 79. MYTRTATTSDSQKNITQSLQFNFLTEPNYDKETVFIKAKGTIGSGLRILDPNGYWNSTLR WPGSYSVSIQNVDDNNNTNVTDFAPKNQDESREVKYTYGYKTGGDFSINRGGLTGNITKE SNYSETISYQQPSYRTLLDQSTSHKGVGWKVEAHLINNMGHDHTRQLTNDSDNRTKSEIF SLTRNGNLWAKDNFTPKDKMPVTVSEGFNPEFLAVMSHDKKDKGKSQFVVHYKRSMDEFK IDWNRHGFWGYWSGENHVDKKEEKLSALYEVDWKTHNVKFVKVLNDNEKK 80. VVKFMNYPNGKPYRKNSAIDGGKKTAAFSNIEYGGRGMSLEKDIEHSNTFYLKSDIAVIH KKPTPVQIVNVNYPKRSKAVINEAYFRTPSTTDYNGVYQGYYIDFEAKETKNKTSFPLNN IHDHQVEHMKNAYQQKGIVFLMIRFKTLDEVYLLPYSKFEVFWKRYKDNIKXSITVDEIR KNGYHIPYQYQPRLDYLKAVDKLILDESEDRV 81. VNTTKAALHGDVKLQNDKDHAKQTVSQLAHLNNAQKHMEDTLIDSETTRTAVKQDLTEAQ ALDQLMDALQQSIADKDATRASSAYVNAEPNKKQSYDEAVQNAESIIAGLNNPTINKGNV SSATQAVISSKNALDGVERLAQDKQTAGNSLNHLDQLTPAQQQALENQINNATTRGEVAQ KLTEAQALNQAMEALRNSIQDQQQTEAGSKFINEDKPQKDAYQAAVQNAKDLINQTNNPT LDKAQVEQLTQAVNQAKDNLHGDQKLADDKQHAVTDLNQLNGLNNPQRQALESQINNAAT RGEVAQKLAEA KALDQAMQALRNSIQDQQQTESGSKFINEDKPQKDAYQAAVQNAKDLIN QTGNPTLDKSQVEQLTQAVTTAKDNLHGDQKLARDQQQAVTTVNALPNLNHAQQQALTDA INAAPTRTEVAQHVQTATELDHAMETLKNKVDQVNTDKAQPNYTEASTDKKEAVDQALQA AESITDPTNGSNANKDAVDQVLTKLQEKENELNGNERVAEAKTQAKQTIDQLTHLNADQI ATAKQNIDQATKLQPIAELVDQATQLNQSMDQLQQAVNEHANVEQTVDYTQADSDKQNAY KQAIADAENVLKQNANKQQVDQALQNILNAKQALNGDERVALAKTNGKHDIDQLNALNNA QQDGFKGRIDQSNDLNQIQQIVDEAKALNRAMDQLSQEITDNEGRTKGSTNYVNADTQVK QVYDETVDKAKQALDKSTGQNLTAKQVIKLNDAVTAAKKALNGEERLNNRKAEALQRLDQ LTHLNNAQRQLAIQQINNAETLNKASRAINRATKLDNAMGAVQQYIDEQHLGVISSTNYI NADDNLKANYDNAIANAAHELDKVQGNAIAKAEAEQLKQNIIDAQNALNGDQNLANAKDK ANAFVNSLNGLNQQQQDLAHKAINNADTVSDVTDIVNNQIDLNDAMETLKHLVDNEIPNA EQTVNYQNADDNAKTNFDDAKRLANTLLNSDNTNVNDINGAIQAVNDAIHNLNGDQRLQD AKDKAIQSINQALANKLKEIEASNATDQDKLIAKNKAEELANSIINNINKATSNQAVSQV QTAGNHAIEQVHANEIPKAKIDANKDVDKQVQALIDEIDRNPNLTDKEKQALKDRINQIL QQGHNGINNAMTKEEIEQAKAQLAQALQDIKDLVKAKEDAKQDVDKQVQALIDEIDQNPN LTDKEKQALKDRINQILQQGHXDIXNAMTKEAIEQAKERLAQALQDIKDLVKAKEDAKND IDKRVQALIDEIDQNPNLTDKEKQALKDRINQILQ QGHNDINNALTKEEIEQAKAQLAQA LQDIKDLVKAKEDAKNAIKALANAKRDQINSNPDLTPEQKAKALKEIDEAEKRALQNVEN AQTIDQLNRGLNLGLDDIRNTHVWEVDEQPAVNEIFEATPEQILVNGELIVHRDDIITEQ DILAHINLIDQLSAEVIDTPSTATISDSLTAKVEVTLLDGSKVIVNVPVKVVEKELSVVK QQAIESIENAAQQKINEINNSVTLTLEQKEAAIAEVNKLKQQAIDHVNNAPDVHSVEEIQ QQEQAHIEQFNPEQFTIEQAKSNAIKSIEDAIQHMIDEIKARTDLTDKEKQEAIAKLNQL KEQAIQAIQRAQSIDEISEQLEQFKAQMKAANPTAKELAKRKQEAISRIKDFSNEKINSI RNSEIGTADEKQAAMNQINEIVLETIRDINNAHTLQQVEAALNNGIARISAVQIVTSDRA KQSSSTGNESNSHLTIGYGTANHPFNSSTIGHKKKLDEDDDIDPLHMRHFSNNFGNVIKN AIGVVGISGLLASFWFFIAKRRRKEDEEEELEIRDNNKDSIKETLDDTKHLPLLFAKRRR KEDEEDVTVEEKDSLNNGESLDKVKHTPFFLPKRRRKEDEEDVEVTNENTDEKVLKDNEH SPLLFAKRRKDKEEDVETTTSIESKDEDVPLLLAKKKNQKDNQSKDKKSASKNTSKKVAA KKKKKKAKKNKK 82. MNQEVKNKIFSILKITFATALFIFVAITLYRELSGINFKDTLVEFSKINRMSLVLLFIGG GASLVILSMYDVILSRALKMDISLGKVLRVSYIINALNAIVGFGGFIGAGVRAMVYKNYT HDKKKLVHFISLILISMLTGLSLLSLLIVFHVFDASLILDKITWVRWVLYVVSFFLPLFI IYSMVRPPDKNNRFVGLYCTLVSCVEWLAAAVVLYFCGVIVDAHVSFMSFIAIFIIAALS GLVSFIPGGFGAFDLVVLLGFKTLGVPEEKVLLMLLLYRFAY YFVPVIIALILSSFEFGT SAKKYIEGSKYFIPAKDVTSFLMSYQKDIIAKIPSLSLAILVFFTSMIFFVNNLTIVYDA LYDGNHLTYYILLAIHTSACLLLLLNVVGIYKQSRRAIIFAMISILLITVATFFTYASYI LITWLAIIFVLLIVAFRRARRLKRPVRMRNIVAMLLFSLFILYVNHIFIAGTLYALDIYT IEMHTSVLRYYFWLTILIIAIIIGMIAWLFDYQFSKVRISSKIEDCEEIINQYGGNYLSH LIYSGDKQFFTNENKTAFLMYRYKASSLVVLGDPLGDENAFDELLEAFYNYAEYLGYDVI FYQVTDQHMPLYHNFGNQFFKLGEEAIIDLTQFSTSGKKRRGFRATLNKFDELNISFEII EPPFSTEFINELQHVSDLWLDNRQEMHFSVGEFNEEYLSKAPIGVMRNEENEVIAFCSLM PTYFNDAISVDLIRWLPELDLPLMDGLYLHMLLWSKEQGYTKFNMGMATLSNVGQLHYSY LRERLAGRVFEHFNGLYRFQGLRRYKSKYNPNWEPRFLVYRKDNSLWESLSKVMRVIRHK 83. MVALTLVGSAVTAHQVQAAETTQDQTTNKNVLDSNKVKATTEQAKAEVKNPTQNISGTQV YQDPAIVQPKTANNKTGNAQVSQKVDTAQVNGDTRANQSATTNNTQPVAKSTSTTAPKTN TNVTNAGYSLVDDEDDNSENQINPELIKSAAKPAALETQYKTAAPKAATTSAPKAKTEAT PKVTTFSASAQPRSVAATPKTSLPKYKPQVNSSINDYIRKNNLKAPKIEEDYTSYFPKYA YRNGVGRPEGIVVHDTANDRSTINGEISYMKNNYQNAFVHAFVDGDRIIETAPTDYLSWG VGAVGNPRFINVEIVHTHDYASFARSMNNYADYAATQLQYYGLKPDSAEYDGNGTVWTHY AVSKYLGGTDHADPHGYLRSHNYSYDQLYDLINEKYLIKMGKVAPWGTQSTTTPTTPSKP T TPSKPSTGKLTVAANNGVAQIKPTNSGLYTTVYDKTGKATNEVQKTFAVSKTATLGNQK FYLVQDYNSGNKFGWVKEGDVVYNTAKSPVNVNQSYSIKPGTKLYTVPWGTSKQVAGSVS GSGNQTFKASKQQQIDKSIYLYGSVNGKSGWVSKAYLVDTAKPTPTPTPKPSTPTTNNKL TVSSLNGVAQINAKNNGLFTTVYDKTGKPTKEVQKTFAVTKEASLGGNKFYLVKDYNSPT LIGWVKQGDVIYNNAKSPVNVMQTYTVKPGTKLYSVPWGTYKQEAGAVSGTGNQTFKATK QQQIDKSIYLFGTVNGKSGWVSKAYLAVPAAPKKAVAQPKTAVKAYTVTKPQTTQTVSKI AQVKPNNTGIRASVYEKTAKNGAKYADRTFYVTKERAHGNETYVLLNNTSHNIPLGWFNV KDLNVQNLGKEVKTTQKYTVNKSNNGLSMVPWGTKNQVILTGNNIAQGTFNATKQVSVGK DVYLYGTINNRTGWVNAKDLTAPTAVKPTTSAAKDYNYTYVIKNGNGYYYVTPNSDTAKY SLKAFNEQPFAVVKEQVINGQTWYYGKLSNGKLAWIKSTDLAKELIKYNQTGMALNQVAQ IQAGLQYKPQVQRVPGKWTGANFNDVKHAMDTKRLAQDPALKYQFLRLDQPQNISIDKIN QFLKGKGVLENQGAAFNKAAQMYGINEVYLISHALLETGNGTSQLAKGADVVNNKVVTNS NTKYHNVFGIAAYDNDPLREGIKYAKQAGWDTVSKAIVGGAKFIGNSYVKAGQNTLYKMR WNPAHPGTHQYATDVDWANINAKIIKGYYDKIGEVGKYFDIPQYK 84. MKGKFLKVSSLFVATLTTATLVSSPAANALSSKAMDNHPQQTQSSKQQTPKIQKGGNLKP LEQREHANVILPNNDRHQITDTTNGHYAPVTYIQVEAPTGTFIASGVVVGKDTLLTNKHV VDATHGDPHALKAFPSAINQDNYPNGGFTAEQITKY SDEGDLAIVKFSPNEQHKHIGEVV KPATMSNNADTQVNQNITVTGYPGDKPVATMWESKGKITYLKGEAMQYDLSTTGGNSGSP VFNEKNEVIGIHWXGVPNEFNGAVFINENVRNFLKQNIEDIHFATMTNLITQIILITLTI LITLTTQMNQITLTTLTTLIIQTMAIXIIQTIQMQLN 85. MQKKVIAAIIGTSAISAVAATQANAATTHTVKPGESVWAISNKYGISIAKLKSLNNLTSN LIFPNQVLKVSGSSNSTSNSSRPSTNSGGGSYYTVQAGDSLSLIASKYGTTYQNIMRLNG LNNFFIYPGQKLKVSGTASSSNAASNSSRPSTNSGGGSYYTVQAGDSLSLIASKYGTTYQ KIMSLNGLNNFFIYPGQKLKVTGNASTNSGSATTTNRGYNTPVFSHQNLYTWGQCTYHVF NRRAEIGKGISTYWWNANNWDNAAAADGYTIDNRPTVGSIAQTDVGYYGHVMFVERVNND GSILVSEMNYSAAPGILTYRTVPAYQVNNYRYIH 86. MNNKKTATNRKGMIPNRLNKFSIRKYSVGTASILVGTTLIFGLSGHEAKAAEHTNGELNQ SKNETTAPSENKTTKKVDSRQLKDNTQTATADQPKVTMSDSATVKETSSNMQSPQNATAN QSTTKTSNVTTNDKSSTTYSNETDKSNLTQAKDVSTTPKTTTIKPRTLNRMAVNTVAAPQ QGTNVNDKVHFSNIDIAIDKGHVNQTTGKTEFWATSSDVLKLKANYTIDDSVKEGDTFTF KYGQYFRPGSVRLPSQTQNLYNAQGNIIAKGIYDSTTNTTTYTFTNYVDQYTNVRGSFEQ VAFAKRKNATTDKTAYKMEVTLGNDTYSEEIIVDYGNKKAQPLISSTNYINNEDLSRNMT AYVNQPKNTYTKQTFVTNLTGYKFNPNAKNFKIYEVTDQNQFVDSFTPDTSKLKDVTDQF DVIYSNDNKTATVDLMKGQTSSNKQYIIQQVAYPDNSSTD NGKIDYTLDTDKTKYSWSNS YSNVNGSSTANGDQKKYNLGDYVWEDTNKDGKQDANEKGIKGVYVILKDSNGKELDRTTT DENGKYQFTGLSNGTYSVEFSTPAGYTPTTANVGTDDAVDSDGLTTTGVIKDADNMTLDS GFYKTPKYSLGDYVWYDSNKDGKQDSTEKGIKGVKVTLQNEKGEVIGTTETDENGKYRFD NLDSGKYKVIFEKPAGLTQTGTNTTEDDKDADGGEVDVTITDHDDFTLDNGYYEEETSDS DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDNDSDSDSDSDSDAGKHTPAKPMSTV KDQHKTAKALPETGSENNNSNNGTLFGGLFAALGSLLLFGRRKKQNK 87. MDINSEEYKQEVLIKDVVMLAARILLESGAEGTRVEDTMTRIAKKLGYSESNSFVTNTVI QFTLHSESFPRIFRITSRDTNLIKISQANKISRQITNNEISLAEAKTQLEKIYVAKRDSS LPFKGFAAAMIAMSFLYLQGGRLIDVLTAILAGSLGYLVTEILDRKLHAQFIPEFIGSLV IGIIAVIGHTLIPTGDLATIIIAAVMPIVPGVLITNAIQDLFGGHMLMFTTKSLEALVTA FGIGAGVGSVLILV 88. VIAIMNVIIDERKENAMTFNKVLLSWIVILIITTSIYLFWQLGDINDVFNQSILINVRLP RLLEALLTGMILTVAGLIFQTVLNNALADSFTLGLASGATFGSGLALFLGLTTLWIPVFS ITFSLITLITVLVITSVLSQGYPVRILILSGLMIGALFNSLLYFLILLKPRKLNTIANYL FGGFGDAEYSNVSIIAITFIIALFGIFIILNQLKLLQLGELKSQSLGLNVQLIT YIALCI ASMITAINVAYVGIIGFIGMVIPQLIRKWQWKQSLGRQLALNIVTGGQIMVMADFIGSHI LSPVQIPASIIIALIGIPVLFYMLISQSKRLH 89. MKKLAFAITATSGAAAFLTHHDAQASTQHTVQSGESLWSIAQKYNTSVESIKQNNQLDNN LVFPGQVISVGGSDAQNTSNTSPQAGSASSHTVQAGESLNIIASRYGVSVDQLMAANNLR GYLIMPNQTLQIPNGGSGGTTPTATTGSNGNASSFNHQNLYTAGQCTWYVFDRRAQAGSP ISTYWSDAKYWAGNAANDGYQVNNTPSVGSIMQSTPGPYGHVAYVERVNGDGSILISEMN YTYGPYNMNYRTIPASEVSSYAFIH 90. MPDSITIIDENKVIDVVLIAGRILLESGAETYRVEDTMNRIAHSYGLHNTYSFVSSTAII FSLNDRTSTRLIRVQERTTDLEKIALTNSLSRKISNKELTIDEAKSEFIHLQHASLQYSF LTNFFAAAIACGFFLFMFGGVASDCWIAVIAGGSAFLTFSFVQRYIQIKFFSEFVAAAVV ISIAATFTKLGIATNQDIITIASVMPLVPGILITNAIRDLLAGELLAGMSRGVEAALTAF AIGAGVAIVLLII 91. MGFLSKILDGNNKEIKQLGKLADKVIALEEKTAILTDEEIRNKTKQFQTELADIDNVKKQ NDYLDKILPEAYALVREGSKRVFNMTPYKVQIMGGIAIHKGDIAEMRTGEGKTLTATMPT YLNALAGRGVHVITVNEYLSSVQSEEMAELYNFLGLTVGLNLNSKTTEEKREAYAQDITY STNNELGFDYLRDNMVNYSEDRVMRPLHFAIIDEVDSILIDEARTPLIISGEAEKSTSLY TQANVFAKMLKQDEDYKYDEKTKAVHLTEQGADKAERMFKVENLYDVQNVDVISHINTAL RAHVTLQRDVDYMVVDGEVLIVDQFTGRTMPGRRFSEGLHQAIEAKEGVQIQNE SKTMAS ITFQNYFRMYNKLAGMTGTAKTEEEEFRNIYNMTVTQIPTNKPVQRNDKSDLIYISQKGK FDAVVEDVVEKHKAGQPVLLGTVAVETSEYISNLLKKRGIRHDVLNAKNHEREAEIVAGA GQKGAVTIATNMAGRGTDIKLGEGVEELGGLAVIGTERHESRRIDDQLRGRSGRQGDKGD SRFYLSLQDELMIRFGSERLQKMMSRLGLDDSTPIESKMVSRAVESAQKRVEGNNFDARK RILEYDEVLRKQREIIYNERNSIIDEEDSSQVVDAMLRSTLQRSINYYINTADDEPEYQP FIDYINDIFLQEGDITEDDIKGKDAEDIFEVVWAKIEAAYQSQKDILEEQMNEFERMILL RSIDSHWTDHIDTMDQLRQGIHLRSYAQQNPLRDYQNEGHELFDIMMQNIEEDTCKFILK SVVQVEDNIEREKTTEFGEAKHVSAEDGKEKVKPKPIVKGDQVGRNDDCPCGSGKKFKNC HGK 92. MRESMSNQNYDYNKNEDGSKKKMSTTAKVVSIATVLLLLGGLVFAIFAYVDHSNKAKERM LNEQKQEQKEKRQKENAEKERKKKQQEEKEQNELDSQANQYQQLPQQNQYQYVPPQQQAP TKQRPAKEENDDKASKDESKDKDDKASQDKSDDNQKKTDDNKQPAQPKPQPQQPTPKPNN NQQNNQSNQQAKPQAPQQNSQSTTNKQNNANDK 93. MNMKKKEKHAIRKKSIGVASVLVGTLIGFGLLSSKEADASENSVTQSDSASNESKSNDSS SVSAAPKTDDTNVSDTKTSSNTNNGETSVAQNPAQQETTQSSSTNATTEETPVTGEATTT TTNQANTPATTQSSNTNAEELVNQTSNETTSNDTNTVSSVNSPQNSTNAENVSTTQDTST EATPSNNESAPQSTDASNKDVVNQAVNTSAPRMRAFSLAAVAADAPAAGTDITNQLTNVT VGIDSGTTVYPHQAGYVKLNYGFSVPNSAVKG DTFKITVPKELNLNGVTSTAKVPPIMAG DQVLANGVIDSDGNVIYTFTDYVNTKDDVKATLTMPAYIDPENVKKTGNVTLATGIGSTT ANKTVLVDYEKYGKFYNLSIKGTIDQIDKTNNTYRQTIYVNPSGDNVIAPVLTGNLKPNT DSNALIDQQNTSIKVYKVDNAADLSESYFVNPENFEDVTNSVNITFPNPNQYKVEFNTPD DQITTPYIVVVNGHIDPNSKGDLALRSTLYGYNSNIIWRSMSWDNEVAFNNGSGSGDGID KPVVPEQPDEPGEIEPIPEDSDSDPGSDSGSDSNSDSGSDSGSDSTSDSGSDSASDSDSA SDSDSASDSDSASDSDSASDSDSDNDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSASDSDSDSDSDSD SDSDSDSDSDSDSDSDSDSDSDSDSDSESDSDSESDSDSDSDSDSDSDSDSDSDSDSASD SDSGSDSDSSSDSDSESDSNSDSESGSNNNVVPPNSPKNGTNASNKNEAKDSKEPLPDTG SEDEANTSLIWGLLASIGSLLLFRRKKENKDKK 94. MNSNHAKASVTESVDKKFVVPESGINKIIPAYDEFKNSPKVNVSNLTDNKNFVASEDKLN KIADSSAASKIVDKNFVVPESKLGNIVPEYKEINNRVNVATNNPASQQVDKHFVAKGPEV NRFITQNKVNHHFITTQTHYKKVITSYKSTHVHKHVNHAKDSINKHFIVKPSESPRYTHP SQSLIIKHHFAVPGYHAHKFVTPGHASIKINHFCVVPQINSFKVIPPYGHNSHRMHVPSF QNNTTATHQNAKVNKAYDYKYFYSYKVVKGVKKYFSFSQSNGYKIGKPSLNIKNVNYQYA VPSYSPTHYVPEFKGSLP APRV 95. LEHTIMKMRTIAKTSLALGLLTTGAITVTTQSVKAEKIQSTKVDKVPTLKAERLAMINIT AGANSATTQAANTRQERTPKLEKAPNTNEEKTSASKIEKISQPKQEEQKTLNISATPAPK QEQSQTTTESTTPKTKVTTPPSTNTPQPMQSTKSDTPQSPTIKQAQTDMTPKYEDLRAYY TKPSFEFEKQFGFMLKPWTTVRFMNVIPNRFIYKIALVGKDEKKYKDGPYDNIDVFIVLE DNKYQLKKYSVGGITKTNSKKVNHKVELSITKKDNQGMISRDVSEYMITKEEISLKELDF KLRKQLIEKHNLYGNMGSGTIVIKMKNGGKYTFELHKKLQEHRMAGTNIDNIEVNIK 96. MTTIKTSNLGFPRLGRKREWKKAIESYWAKKISKEELDQTLTDLHKENLLLQKYYHLDSI PVGDFSLYDHILDTSLLFNIIPERFQGRTIDDDLLFDIARGNKDHVASALIKWFNTNYHY IVPEWDNVEPKVSRNVLLDRFKYAQSLNVNAHPVIVGPITFVKLSKGGHQTFEEKVKTLL PLYKEVFESLIDAGAEYIQVDEPILVTDDSESYENITREAYDYFEKAGVAKKLVIQTYFE RAHLKFLSSLPVGGIGLDFVHDNGYNLKQIEAGDFDKSKTLYAGIIDGRNVWASDIEAKK VLIDKLLAHTNELVIQPSSSLLHVPVSLDDETLDTSVGEGLSFATEKLDELDALRRLFNQ NDSVKYDKLKARYERFQNQSFKNLDYDFESVRTSRQSPFAQRIEQQQKRLNLPDLPTTTI GSFPQSREVRKYRADWKNKRITDEAYETFLKNEIARWIKIQEDIGLDVLVHGEFERNDMV EFFGEKLQGFLVTKFGWVQSYGSRAVKPPIIYGDVKWTAPLTVDETVYAQSLTDKPVKGM LTGPVTILNWSFERVDLPRKVVQDQIALAINEEVLALEAAGIKVIQVDEPALREGLPLRS EYHEQYLKDAVLSF KLATSSVRDETQIHTHMCYSQFGQIIHAIHDLDADVISIETSRSHG DLIKDFEDINYDLGIGLGVYDIHSPRIPTKEEITTAINRSLQQIDRSLFWVNPDCGLKTR KEEEVKDALTVLVNAVKAKRQE 97. MSDTYKSYLVAVLCFTVLAIVLMPFLYFTTAWSIAGFASIATFIFYKEYFYEE 98. MLRGQEERKYSIRKYSIGVVSVLAATMFVVSSHEAQASEKTSTNAAAQKETLNQPGEQGN AITSHQMQSGKQLDDMHKENGKSGTVTEGKDTLQSSKHQSTQNSKTIRTQNDNQVKQDSE RQGSKQSHQNNATNNTERQNDQVQNTHHAERNGSQSTTSQSNDVDKSQPSIPAQKVIPNH DKAAPTSTTPPSNDKTAPKSTKAQDATTDKHPNQQDTHQPAHQIIDAKQDDTVRQSEQKP QVGDLSKHIDGQNSPEKPTDKNTDNKQLIKDALQAPKTRSTTNAAADAKKVRPLKANQVQ PLNKYPVVFVHGFLGLVGDNAPALYPNYWGGNKFKVIEELRKQGYNVHQASVSAFGSNYD RAVELYYYIKGGRVDYGAAHAAKYGHERYGKTYKGIMPNWEPGKKVHLVGHSMGGQTIRL MEEFLRNGNKEEIAYHKAHGGEISPLFTGGHNNMVASITTLATPHNGSQAADKFGNTEAV RKIMFALNRFMGNKYSNIDLGLTQWGFKQLPNESYIDYIKRVSKSKIWTSDDNAAYDLTL DGSAKLNNMTSMNPNITYTTYTGVSSHTGPLGYENPDLGTFFLMATTSRIIGHDAREEWR KNDGVVPVISSLHPSNQPFVNVTNDEPATRRGIWQVKPIIQGWD 99. MIHLIKGKMHHTVLCIHLNKGVALMNQYHSNAQQPSAWRFFVYSLVGILCFFIPFTINGN NTIFVDHVHLAIRSIIGPLMPYVALIMILIGTALPIVRRTFMTSITNLVITLFKVAGAMI GIMYVFKIGPSILFKANYGPFLFEKL MMPLSILIPVGAIALSLLVGYGLLEFVGVYMEPI MRPIFKTPGKSAVDAVASFVGSYSLGLLITNRVYKQGMYNKREATIIATGFSTVSATFMI IVAKTLGLMPHWNLYFWITLVITFVVTAITAWLPPISNESTEYYNGQEGEQEVAIEGSRL KTAYAEAMKQNALTPSLVKNVWDNLKDGLEMTVGILPSILSIGFLGLIVANYTPFIDWLG YIFYPFIYIFPIADQALLAKASAISIVEMFLPSLLVTKAAMSTKFVVGVVSVSAIIFFSA LVPCILATEIKIPVWKLIIIWFLRVALSLLITIPVALLIFG 100. MVIMKKTILLTMTTLTLFSMSPNSAQAYTNDSKTLEEAKKAHPNAQFKVNKDTGAYTYTY DKNNTPNNNHQNQSRTNDNHQHANQRDLNNNQYHSSLSGQYTHINDAIDSHTPPQTSPSN PLTPAIPNVEDNDDELNNAFSKDNKGLITGIDLDELYDELQIAEFNDKAKTADGKPLALG NGKIIDQPLITSKNNLYTAGQCTWYVFDKRAKDGHTISTFWGDAKNWAGQASSNGFKVDR HPTRGSILQTVNGPFGHVAYVEKVNIDGSILISEMNWIGEYIVSSRTISASEVSSYNYIH 101. MEVSSMKPYIQLVVFKQWLQYILLVTTIVIALVLIGIGYRVAHDNFKIPITIQDLDQTTA SKSFVNKIKQSDYVTIKKVDEDESYIEDDVTKKEAILSMQIPKGFSQKLKENRLKETIQL YGRDDFIGGIAVEIVSSSLYEQQIPNIIYEHLEDMKQHQSIDAINKSYHKHTPESKIKFV SLTKQAQHSISISLIFAVILFVSAVQVVLHYRLNQQAALQRLSQYHLSRFKLYSTYVMTH TILLLLVLLAVSLYLSQPLSLIFYLKSLLLILIYEIGIVFILFHIQTISHRLFMTFIYAL AMGIVYLIIFM 102. MIEVTEMNFFDIHKIPNKGIPLSVQRKLWLRNFMQAFFVVFF VYMAMYLIRNNFKAAQPF LKEEIGLSTLELGYIGLAFSITYGLGKTLLGYFVDGRNTKRIISFLLILSAITVLIMGFV LSYFGSVMGLLIVLWGLNGVFQSVGGPASYSTISRWAPRTKRGRYLGFWNTSHNIGGAIA GGVALWGANVFFHGNVIGMFIFPSVIALLIGIATLFIGKDDPEELGWNRAEEIWEEPVDK ENIDSQGMTKWEIFKKYILGNPVIWILCVSNVFVYIVRIGIDNWAPLYVSEHLHFSKGDA VNTIFYFEIGALVASLLWGYVSDLLKGRRAIVAIGCMFMITFVVLFYTNATSVMMVNISL FALGALIFGPQLLIGVSLTGFVPKNAISVANGMTGSFAYLFGDSMAKVGLAAIADPTRNG LNIFGYTLSGWTDVFIVFYVALFLGMILLGIVAFYEEKKIRSLKI 103. MTKKKNILKAIGIYSFIAMMFVIILYPLLWTFGISLNPGTNLYGAKMIPDNATFKNYAFL LFDDSSQYLTWYKNTLIVASANALFSVIFVTLTAYAFSRYRFVGRKYGLITFLILQMFPV LMAMVAIYILLNTIGLLDSLFGLTLVYIGGSIPMNAFLVKGYFDTIPKELDESAKIDGAG HMRIFLQIMLPLAKPILAVVALFNFMGPFMDFILPKILLRSPEKFTLAVGLFNFINDKYA NNFTVFAAGAIMIAVPIAIVFLFLQRYLVSGLTTGATKG 104. MMENSTTEARNEATMHLDEMTVEEALITMNKEDQQVPLAVRKAIPQLTKVIKKTIAQYKK GGRLIYIGAGTSGRLGVLDAAECVPTFNTDPHEIIGIIAGGQHAMTMAVEGAEDHKKLAE EDLKNIDLTSKDVVIGIAASGKTPYVIGGLTFANTIGATTVSISCNEHAVISEIAQYPVE VKVGPEVLTGSTRLKSGTAQKLILNMISTITMVGVGKVYDNLMIDVKATNQKLIDRSVRI IQEICAITYDEAMALYQVSEHDVKVATVMGM CGISKEEATRRLLNNGDIVKRAIRDRQP 105. LQYIIRYIMMTLQIHTGGINLKKKNIYSIRKLGVGIASVTLGTLLISGGVTPAANAAQHD EAQQNAFYQVLNMPNLNADQRNGFIQSLKDDPSQSANVLGEAQKLNDSQAPKADAQQNNF NKDQQSAFYEILNMPNLNEAQRNGFIQSLKDDPSQSTNVLGEAKKLNESQAPKADNNFNK EQQNAFYEILNMPNLNEEQRNGFIQSLKDDPSQSANLLSEAKKLNESQAPKADNKFNKEQ QNAFYEILHLPNLNEEQRNGFIQSLKDDPSQSANLLAEAKKLNDAQAPKADNKFNKEQQN AFYEILHLPNLTEEQRNGFIQSLKDDPSVSKEILAEAKKLNDAQAPKEEDNNKPGKEDNN KPGKEDNNKPGKEDNNKPGKEDGNKPGKEDNKKPGKEDGNKPGKEDNKKPGKEDGNKPGK EDGNKPGKEDGNGVHVVKPGDTVNDIAKANGTTADKIAADNKLADKNMIKPGQELVVDKK QPANHADANKAQALPETGEENPFIGTTVFGGLSLALGAALLAGRRREL 106. MDKKSEKRGIKMTVQSAYIHIPFCVRICTYCDFNKYFIQNQPVDEYLDALITEMSTAKYR ILKTMYVGGGTPTALSINQLERLLKAIRDTFTITGEYTFEANPDELTKEKVQLLEKYGVK RISMGVQTFKPELLSVLGRTHNTEDIYTSVLNAKNAGIKSISLDLMYHLPKQTIEDFEQS LDLALDMDIQHISSYGLILEPKTQFYNMYRKGLLKLPNEDLGADMYQLLMSKIEQSPFHQ YEISNFALDGHESEHNKVYWFNEEYYGFGAGASGYVDGVRYTNINPVNHYIKAINKESKA ILVSNKPSLTERMEEEMFLGLRLNEGVSSSRFKKKFDQSIESVFGQTINNLKEKELIVEK NDVIALTNRGKVIGNEVFEAFLIND 107. atgaatgtattagtaattggtgctggt ggacgagaacatgcacttgcatataaacttaat caatcgaatctagttaaacaagtgtttgtcattccaggtaatgaggcaatgacacctata gctgaagtacacactgaaatttcagaacctgatcatcaagcgatactagattttgctaaa cggcaaaatgttgattgggtagttataggtccagaacagccgctaattgatggattagca gacattttacgagcgaatggtttcaaagtgtttggtccaaataagcaagcagctcaaatc gaaggctcaaaattatttgctaaaaagataatggaaaaatataatattccaactgctgat tataaagaagttgagcgaaaaaaggatgctttaacatatattgaaaactgtgaattgccc gttgttgtcaagaaagatgggttagctgctgggaaaggcgttattattgcagatactatt gaagcagccagaagtgctattgagattatgtatggtgatgaagaagaaggtactgttgta tttgaaacgtttttagaaggtgaagagttctcgctaatgacatttgttaatggtgattta gcagtacctttcgactgtattgcacaagatcataaacgcgcatttgatcatgatgaagga ccaaatactggtggtatgggggcttattgtccagtaccacatattagtgacgatgtttta aaacttacaaatgaaacaattgcacaacccattgcaaaggcaatgcttaatgaaggttat caattcttcggtgtattatacattggtgctattttaactaaagatggtccaaaagtaata gaatttaatgcccgttttggtgatcctgaagctcaagtattattaagtcgcatggaaagt gatttaatgcagcatattattgatttagatgaaggaaaacgtactgaattcaaatggaaa aatgaatctattgtaggggtcatgttggcatcaaaaggatatcctgatgca tatgaaaaa gggcataaagtaagtggctttgatttaaatgaaaactattttgttagtggattaaagaag caaggtgatacctttgttacttcaggtggtagagttatacttgccatcggaaaaggtgac aatgtacaagatgcacagcgagacgcatacaaaaaagtatcacaaatacaaagtgaccat ttattctatcgtcatgacattgcgaataaagcactacaacttaaa 108. MNVLVIGAGGREHALAYKLNQSNLVKQVFVIPGNEAMTPIAEVHTEISEPDHQAILDFAK RQNVDWVVIGPEQPLIDGLADILRANGFKVFGPNKQAAQIEGSKLFAKKIMEKYNIPTAD YKEVERKKDALTYIENCELPVVVKKDGLAAGKGVIIADTIEAARSAIEIMYGDEEEGTVV FETFLEGEEFSLMTFVNGDLAVPFDCIAQDHKRAFDHDEGPNTGGMGAYCPVPHISDDVL KLTNETIAQPIAKAMLNEGYQFFGVLYIGAILTKDGPKVIEFNARFGDPEAQVLLSRMES DLMQHIIDLDEGKRTEFKWKNESIVGVMLASKGYPDAYEKGHKVSGFDLNENYFVSGLKK QGDTFVTSGGRVILAIGKGDNVQDAQRDAYKKVSQIQSDHLFYRHDIANKALQLK 109. atgcaaccacatttaatatgtctagacttagacggaacattattaaacgataacaaagaa atttcatcatatactaaacaagtattaaatgaattacaacaacgtggacaccaaattatg attgcgactggcagaccttatcgtgcaagtcaaatgtattatcatgaattaaatttaacg acaccaattgttaattttaatggcgcttacgtacatcaccctaaagataaaaacttcaaa acttgccatgaaattttagatttaggcatcgcacaaaacattattcaaggattacaacaa tatcaagtatcgaatattatagca gaagtgaaagattatgttttcattaacaatcatgat ccaagattatttgaaggtttttcaatgggtaatccaagaattcaaactggtaatttactt gtccacttgaaagaatcccctacctcaattttaattgaagccgaagaaagtaaaatacct gaaatcaaaaatatgcttactcatttttatgccgatcatattgagcatcgacgctggggc gcaccattccctgtcattgaaattgtaaaacttggtattaataaagcaagaggcattgag caagttagacaatttttaaatattgaccgaaataatattattgcattcggtgatgaagat aatgatattgaaatgattgagtacgcgcgtcacggtgttgctatggaaaatggtttgcaa gaacttaaagatgtagcgaacaatattacattcaacaataatgaagatggcattggtcga tatttgaatgatttctttaatttaaatattagatattactgt 110. MQPHLICLDLDGTLLNDNKEISSYTKQVLNELQQRGHQIMIATGRPYRASQMYYHELNLT TPIVNFNGAYVHHPKDKNFKTCHEILDLGIAQNIIQGLQQYQVSNIIAEVKDYVFINNHD PRLFEGFSMGNPRIQTGNLLVHLKESPTSILIEAEESKIPEIKNMLTHFYADHIEHRRWG APFPVIEIVKLGINKARGIEQVRQFLNIDRNNIIAFGDEDNDIEMIEYARHGVAMENGLQ ELKDVANNITFNNNEDGIGRYLNDFFNLNIRYYC 111. gtgaaaccaatggctaagtctaatagtaaagacatcgttttaattggagccggtgtactt agcacaacatttggttcaatgttaaaagaaattgagccagactggaatatccacgtttac gaacgcttggatcgtcctgcaatcgaaagttcaaacgaaagaaataatgctggtacgggt catgcagcattatgtgagttg aactacacagttttacaacctgatggttctatcgacatc gaaaaagcgaaagtgattaacgaagagtttgagatttcaaaacaattctggggtcactta gtgaaaagcggtagcatcgagaacccaagagaatttatcaatccattaccacacatcagt tatgttagaggtaaaaacaatgttaaattcttaaaagatcgttacgaagcgatgaaagct ttccctatgttcgataatatcgaatatactgaagacatcgaagtaatgaaaaaatggatt ccattgatgatgaaaggccgtgaagataaccctggtatcatggcggcaagtaaaattgac gaaggtacagatgtaaacttcggtgaattaacacgtaaaatggctaaaagcattgaagca catccaaatgctacagtgcaatttaaccatgaagttgttgattttgaacaattatcaaat ggtcaatgggaagttactgttaaaaatcgcctaactggtgagaaattcaaacaagtaact gactacgtattcatcggtgctggcggtggagcaattccattattacaaaaaacaggtatc cctgaaagtaaacatttgggtggattccctatcagtggtcaattcttagcttgtacaaac ccacaagttattgaacaacacgatgccaaagtttatggtaaagagccacctggtacacca ccaatgactgtacctcatttagatacgcgttacattgatggtcaaagaacattattattt ggaccatttgctaatgttggacctaaattcttgaaaaatggttctaacttagatttattc aagtctgttaaaacatacaacattacaactttattagcagcagcagttaaaaacttacct ttaattaaatactcatttgaccaagtaattatgacaaaagaaggttgtatgaaccactta cgtactttctatccagaagcacgtaatgaagattggcaattatac actgctggtaaacgt gtacaagttatcaaagatacacctgaacacggtaaaggattcatccaattcggtacagaa gtggttaactcacaagaccacactgtaattgcattattaggtgaatcaccaggggcttca acttcagtttcagttgcgttagaagtattagaacgtaacttccctgaatacaaaactgaa tgggcacctaaaattaagaaaatgattccatcatacggtgaatcattaattgaagacgaa aaattaatgagaaaaatccgtaaacaaacttcaaaagacttagaattaggttactacgaa aac 112. MKPMAKSNSKDIVLIGAGVLSTTFGSMLKEIEPDWNIHVYERLDRPAIESSNERNNAGTG HAALCELNYTVLQPDGSIDIEKAKVINEEFEISKQFWGHLVKSGSIENPREFINPLPHIS YVRGKNNVKFLKDRYEAMKAFPMFDNIEYTEDIEVMKKWIPLMMKGREDNPGIMAASKID EGTDVNFGELTRKMAKSIEAHPNATVQFNHEVVDFEQLSNGQWEVTVKNRLTGEKFKQVT DYVFIGAGGGAIPLLQKTGIPESKHLGGFPISGQFLACTNPQVIEQHDAKVYGKEPPGTP PMTVPHLDTRYIDGQRTLLFGPFANVGPKFLKNGSNLDLFKSVKTYNITTLLAAAVKNLP LIKYSFDQVIMTKEGCMNHLRTFYPEARNEDWQLYTAGKRVQVIKDTPEHGKGFIQFGTE VVNSQDHTVIALLGESPGASTSVSVALEVLERNFPEYKTEWAPKIKKMIPSYGESLIEDE KLMRKIRKQTSKDLELGYYEN 113. atgctagaggcacaattttttactgatactggacaacatagagataagaatgaagatgcg ggtggtattttttataatcaaactaatcaacaacttttagttctgtgtgatggtatgggt ggccataaagcaggagaagttgcaagtaaattt gttacagatgagttgaaatcccgtttt gaagcggaaaatcttatagaacaacatcaagctgaaaattggttgcgtaataatataaaa gatataaattttcagttatatcactatgcacaagaaaatgcagaatataaaggtatgggt acaacatgtgtttgtgcacttgtttttgaaaaatcagttgtgatagcaaatgtcggtgat tctagagcctatgttattaatagtcgacaaattgaacaaattactagtgatcactcattt gttaatcatcttgttttaacgggtcaaattacgccggaagaagcatttacacatccacaa cgtaatattattacgaaggtgatgggcacagataaacgtgtgagtccagatttgtttatt aagcgattaaatttttatgattatttattattaaattcagatggattaactgattatgtt aaagacaatgaaattaagcgtttgttagtaaaagaaggtacaatagaagatcatggtgat caattaatgcaattggcattagataaccattcgaaagataacgttactttcatactcgcg gctattgaaggtgataaagta 114. matdtghrdkndaggyntnvcdgmgghkagvaskvtdksranhanwrnnkdnyhyanayk gmgttcvcavksvvanvgdsrayvnsrtsdhsvnhvtgtathrntkvmgtdkrvsdkrny dynsdgtdyvkdnkrvkgtdhgdmadnhskdnvtaagdkv 115. atggcaaaagaaaaattcgatcgttctaaagaacatgccaatatcggtactatcggtcac gttgaccatggtaaaacaacattaacagcagcaatcgctactgtattagcaaaaaatggt gactcagttgcacaatcatatgacatgattgacaacgctccagaagaaaaagaacgtggt atcacaatcaatacttctcacattgagtaccaaactgacaaacgt cactacgctcacgtt gactgcccaggacacgctgactacgttaaaaacatgatcactggtgctgctcaaatggac ggcggtatcttagtagtatctgctgctgacggtccaatgccacaaactcgtgaacacatt cttttatcacgtaacgttggtgtaccagcattagtagtattcttaaacaaagttgacatg gttgacgatgaagaattattagaattagtagaaatggaagttcgtgacttattaagcgaa tatgacttcccaggtgacgatgtacctgtaatcgctggttcagcattaaaagctttagaa ggcgatgctcaatacgaagaaaaaatcttagaattaatggaagctgtagatacttacatt ccaactccagaacgtgattctgacaaaccattcatgatgccagttgaggacgtattctca atcactggtcgtggtactgttgctacaggccgtgttgaacgtggtcaaatcaaagttggt gaagaagttgaaatcatcggtttacatgacacatctaaaacaactgttacaggtgttgaa atgttccgtaaattattagactacgctgaagctggtgacaacattggtgcattattacgt ggtgttgctcgtgaagacgtacaacgtggtcaagtattagctgctcctggttcaattaca ccacatactgaattcaaagcagaagtatacgtattatcaaaagacgaaggtggacgtcac actccattcttctcaaactatcgtccacaattctatttccgtactactgacgtaactggt gttgttcacttaccagaaggtactgaaatggtaatgcctggtgataacgttgaaatgaca gtagaattaatcgctccaatcgcgattgaagacggtactcgtttctcaatccgtgaaggt ggacgtactgtaggatcaggcgttgttactgaaatcattaaa 116. MAKEKFDRSKEHANIGTIGHV DHGKTTLTAAIATVLAKNGDSVAQSYDMIDNAPEEKERG ITINTSHIEYQTDKRHYAHVDCPGHADYVKNMITGAAQMDGGILVVSAADGPMPQTREHI LLSRNVGVPALVVFLNKVDMVDDEELLELVEMEVRDLLSEYDFPGDDVPVIAGSALKALE GDAQYEEKILELMEAVDTYIPTPERDSDKPFMMPVEDVFSITGRGTVATGRVERGQIKVG EEVEIIGLHDTSKTTVTGVEMFRKLLDYAEAGDNIGALLRGVAREEIQRGQVLAAPGSIT PHTEFKAEVYVLSKDEGGRHTPFFSNYRPQFYFRTTDVTGVVHLPEGTEMVMPGDNVEMT VELIAPIAIDEGTRFSIREGGRTVGSGVVTEITE 117. atgactaagagtgctttagtaacaggtgcatcaagaggaattggacgtagtattgcgtta caattagcagaagaaggatataatgtagcagtaaactatgcaggcagcaaagagaaagct gaagcagtagtcgaagaaatcaaagctaaaggtgttgaaagttttgcgattcaagcaaat gttgccgatgcatgaaaatgactaagagtgctttagtaacaggtgcatcaagaggaattg gacgtagtattgcgttacaattagcagaagaaggatataatgtagcagtaaactatgcag gcagcaaagagaaagctgaagcagtagtcgaagaaatcaaagctaaaggtgttgaaagtt ttgcgattcaagcaaatgttgccgatgctgatgaagttaaagcaatgattaaagaagtag ttagccaatttggttctttagatgttttagtaaataatgcaggtattactcgcgataatt tattaatgcgtatgaaagaacaagagtgggatgatgttattgacacaaacttaaaaggtg tatttaactgtatccaaaaagcaacaccacaaatgttaagacaacgtagtggtgctatca tcaat ttatcaagtgttgttggagcagtaggtaatccgggacaagcaaactatgttgcaa caaaagcaggtgttattggtttaactaaatctgcggcgcgtgaattagcatctcgtggta tcactgtaaatgcagttgcacctggttttattgtttctgatatgacagatgctttaagtg atgagcttaaagaacaaatgttgactcaaattccgttagcacgttttggtcaagacacag atattgctaatacagtagcgttcttagcatcagacaaagcaaaatatattacaggtcaaa caatccatgtaaatggtggaatgtacatg 118. MTKSALVTGASRGIGRSIALQLAEEGYNVAVNYAGSKEKAEAVVEEIKAKGVESFAIQAN VADADEVKAMIKEVVSQFGSLDVLVNNAGITRDNLLMRMKEQEWDDVIDTNLKGVFNCIQ KATPQMLRQRSGAIINLSSVVGAVGNPGQANYVATKAGVIGLTKSAARELASRGITVNAV APGFIVSDMTDALSDELKEQMLTQIPLARFGQDTDIANTVAFLASDKAKYITGQTIHVNG GMYM 119. atgaaaatttctactaaagggagatatggacttacattgatgatttctcttgctaaaaaa gaggggcaaggatgtatatcattaaagtcaattgctgaagaaaataatttgagtgattta tatttagaacagcttgtaggtcctttaagaaatgcggggttaattcgaagtgtacgcggt gctaaaggtggataccaattaagagtgccagcggaagaaatctcagcaggggatattata agactgttagaaggtccaattacatttgttgaaagtattgaatcagaaccacctgcgcaa aaacaactatggattcgcatgagagatgcagtgagagatgttttagataatacaacattg aaatatttagcggaatatgtagatacaagtgaagatttagacgga tacatgttttatatt 120. MLKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQLVSPLRNAGLVKSIR GAYGGYVLGSEPDAITAGDIIRVLEGPISLLKCWKMRSLPSVSSGFASGML 121. gtggcatttgaatttagattacccgatatcggggaaggtatccacgaaggtgaaattgta aaatggtttgttaaagctggagatactattgaagaagacgatgttttagctgaggtacaa aacgataaatcagtagtagaaatcccatcaccagtatctggtactgtagaagaagttatg gtagaagaaggtacagtagctgtagttggtgacgttattgttaaaatcgatgcacctgat gcagaagatatgcaatttaaaggtcatgatgatgattcatcatctaaagaagaacctgcg aaagaggaagcgccagcagagcaagcacctgtagctactcaaactgaagaagtagatgaa aacagaactgttaaagcaatgccttcagtacgtaaatacgcacgtgaaaaaggtgttaac attaaagcagtttctggatctggtaaaaatggtcgtattacaaaagaagatgtagatgca tacttaaatggtggtgcaccaacagcttcaaatgaatcagctgcttcagctacaagtgaa gaagttgctgaaactcctgcagcacctgcagcagtaacattagaaggcgacttcccagaa acaactgaaaaaatccctgctatgcgtagagcaattgcgaaagcaatggttaactctaag catactgcacctcatgtaacattaatggatgaaattgatgttcaagcattatgggatcac cgtaagaaatttaaagaaatcgcagctgaacaaggtactaagttaacattcttaccttat gttgttaaagcacttgtttctgcattgaaaaaatacccagcacttaacacttcattcaat gaagaag ctggtgaaatcgttcataaacattactggaatatcggtattgcagcagacact gatagaggattattagtacctgttgttaaacatgctgatcgtaagtctattttccaaatt tcagatgaaattaatgaattagctgttaaagcacgtgatggtaaattaacagccgatgaa atgaaaggtgctacatgcacaatcagtaatatcggttcagctggtggacaatggttcact ccagttatcaatcacccagaagtagcaatcttaggaattggccgtattgctcaaaaacct atcgttaaagatggagaaattgttgcagcaccagtattagcattatcattaagctttgac cacagacaaattgatggtgcaactggccaaaatgcaatgaatcacattaaacgtttatta aataatccagaattattattaatggagggg 122. MAFEFRLPDIGEGIHEGEIVKWFVKAGDTIEEDDVLAEVQNDKSVVEIPSPVSGTVEEVM VEEGTVAVVGDVIVKIDAPDAEDMQFKGHDDDSSSKEEPAKEEAPAEQAPVATQTEEVDE NRTVKAMPSVRKYAREKGVNIKAVSGSGKNGRITKEDVDAYLNGGAPTASNESAASATSE EVAETPAAPAAVTLEGDFPETTEKIPAMRRAIAKAMVNSKHTAPHVTLMDEIDVQALWDH RKKFKEIAAEQGTKLTFLPYVVKALVSALKKYPALNTSFNEEAGEIVHKHYWNIGIAADT DRGLLVPVVKHADRKSIFQISDEINELAVKARDGKLTADEMKGATCTISNIGSAGGQWFT PVINHPEVAILGIGRIAQKPIVKDGEIVAAPVLALSLSFDHRQIDGATGQNAMNHIKRLL 123. atgctaaacagagaaaataaaacggcaataacaaggaaaggcatggtatccaatcgatta aataaattttcgattagaaagtacacagtgggaacagcatcaattttagta ggtacaaca ttaatttttggtctggggaaccaagaagcaaaggctgcagaaagtactaataaagaattg aacgaagcgacaacttcagcaagtgataatcaatcgagtgataaagttgatatgcagcaa ctaaatcaagaagacaatactaaaaatgataatcaaaaagaaatggtatcatctcaaggt aatgaaacgacttcaaatgggaataaattaatagaaaaagaaagtgtacaatctaccact ggaaataaagttgaagtttcaactgccaaatcagatgagcaagcttcaccaaaatctacg aatgaagatttaaacactaaacaaactataagtaatcaagaagcgttacaacctgatttg caagagaataaatcagtggtaaatgttcaaccaactaatgaggaaaacaaaaaggtagat gccaaaactgaatcaactacattaaatgttaaaagtgatgctatcaagagtaatgatgaa actcttgttgataacaatagtaattcaaataatgaaaataatgcagatatcattttgcca aaaagtacagcacctaaacgtttgaatacaagaatgcgtatagcagcagtacagccatca tcaacagaggctaaaaatgttaatgatttaatcacatcaaatacaacattaactgtcgtt gatgcagataaaaacaataaaatcgtaccagcccaagattatttatcattaaaatcacaa attacagttgatgacaaagttaaatcaggtgattatttcacaattaaatactcagataca gtacaagtatatggattgaatccggaagatattaaaaatattggtgatattaaagatcca aataatggtgaaacaattgcgactgcaaaacatgatactgcaaataatttaattacatat acatttacagattatgttgatcgatttaattctgtacaaatgggaattaattattcaatt tatatggatgctga tacaattcctgttagtaaaaacgatgttgagtttaatgttacgata ggtaatactacaacaaaaacaactgctaacattcaatatccagattatgttgtaaatgag aaaaattcaattggatcagcgttcactgaaacagtttcacatgttggaaataaagaaaat ccagggtactataaacaaacgatttatgtaaatccatcggaaaattctttaacaaatgcc aaactaaaagttcaagcttaccactcaagttatcctaataatatcgggcaaataaataaa gatgtaacagatataaaaatatatcaagttcctaaaggttatacattaaataaaggatac gatgtgaatactaaagagcttacagatgtaacaaatcaatacttgcagaaaattacatat ggcgacaacaatagcgctgttattgattttggaaatgcagattctgcttatgttgtaatg gttaatacaaaattccaatatacaaatagcgaaagcccaacacttgttcaaatggctact ttatcttcaacaggtaataaatccgtttctactggcaatgctttaggatttactaataac caaagtggcggagctggtcaagaagtatataaaattggtaactacgtatgggaagatact aataaaaacggtgttcaagaattaggagaaaaaggcgttggcaatgtaactgtaactgta tttgataataatacaaatacaaaagtaggagaagcagttactaaagaagatgggtcatac ttgattccaaacttacctaatggagattaccgtgtagaattttcaaacttaccaaaaggt tatgaagtaaccccttcaaaacaaggtaataacgaagaattagattcaaacggcttatct tcagttattacagttaatggcaaagataacttatctgcagacttaggtatttacaaacct aaatacaacttaggtgactatgtctgggaagatacaaa taaaaatggtatccaagaccaa gatgaaaaaggtatatctggcgtaacggtaacattaaaagatgaaaacggtaacgtgtta aaaacagttacaacagacgctgatggcaaatataaatttactgatttagataatggtaat tataaagttgaatttactacaccagaaggctatacaccgactacagtaacatctggtagc gacattgaaaaagactctaatggtttaacaacaacaggtgttattaatggtgctgataac atgacattagatagtggattctacaaaacaccaaaatataatttaggtaattatgtatgg gaagatacaaataaagatggtaagcaggattcaactgaaaaaggtatttcaggcgtaaca gttacattgaaaaatgaaaacggtgaagttttacaaacaactaaaacagataaagatggt aaatatcaatttactggattagaaaatggaacttataaagttgaattcgaaacaccatca ggttacacaccaacacaagtaggttcaggaactgatgaaggtatagattcaaatggtaca tcaacaacaggtgtcattaaagataaagataacgatactattgactctggtttctacaaa ccgacttacaacttaggtgactatgtatgggaagatacaaataaaaacggtgttcaagat aaagatgaaaagggcatttcaggtgtaacagttacgttaaaagatgaaaacgacaaagtt ttaaaaacagttacaacagatgaaaatggtaaatatcaattcactgatttaaacaatgga acttataaagttgaattcgagacaccatcaggttatacaccaacttcagtaacttctgga aatgatactgaaaaagattctaatggtttaacaacaacaggtgtcattaaagatgcagat aacatgacattagacagtggtttctataaaacaccaaaatatagtttaggtgattatgtt t ggtacgacagtaataaagacggcaaacaagattcaactgaaaaaggtatcaaagatgtt aaagttactttattaaatgaaaaaggcgaagtaattggaacaactaaaacagatgaaaat ggtaaatactgctttgataatttagatagcggtaaatacaaagttatttttgaaaagcct gctggcttaacacaaacaggtacaaatacaactgaagatgataaagatgcagatggtggc gaagttgacgtaacaattacggatcatgatgatttcacacttgataatggctactacgaa gaagaaacatcagatagcgactcagattcggacagcgactcagattcagacagagactca gactcagatagtgattcagactcggatagcgattcagattcagacagcgattcagattca gatagcgattcagattcagacagagactcagatagtgattcagactcagatagcgactca gattcagacagcgactcagattcagacagcgactcagactcagatagtgattcagactca gatagcgactcagattcagacagcgactcagactcagacagcgactcagactcagatagt gactcagattcagatagcgactcagattcggacagcgattcagactcagatagcgactca gattcagatagcgattcggactcagatagcgactcagattcagatagtgattcagactca gatagcgactcagattcagacagcgactcagattcggatagcgactcagattcagacagc gactcagactcggatagtgattcagactcagatagcgactcagactcagatagcgattca gattcagatagcgactcagactcagacagcgattcagactcagacagcgactcagactca gatgcaggtaagcacacacctgttaaaccaatgagtactactaaagaccatcacaataaa gcaaaagcattaccagaaacaggta atgaaaatagcggctcaaataacgcaacgttattt ggcggattattcgcagcattaggatcattattgttattcggtcgtcgtaaaaaacaaaat aaa 124. MLNRENKTAITRKGMVSNRLNKFSIRKYTVGTASILVGTTLIFGLGNQEAKAAESTNKEL NEATTSASDNQSSDKVDMQQLNQEDNTKNDNQKEMVSSQGNETTSNGNKLIEKESVQSTT GNKVEVSTAKSDEQASPKSTNEDLNTKQTISNQEALQPDLQENKSVVNVQPTNEENKKVD AKTESTTLNVKSDAIKSNDETLVDNNSNSNNENNADIILPKSTAPKRLNTRMRIAAVQPS STEAKNVNDLITSNTTLTVVDADKNNKIVPAQDYLSLKSQITVDDKVKSGDYFTIKYSDT VQVYGLNPEDIKNIGDIKDPNNGETIATAKHDTANNLITYTFTDYVDRFNSVQMGINYSI YMDADTIPVSKNDVEFNVTIGNTTTKTTANIQYPDYVVNEKNSIGSAFTETVSHVGNKEN PGYYKQTIYVNPSENSLTNAKLKVQAYHSSYPNNIGQINKDVTDIKIYQVPKGYTLNKGY DVNTKELTDVTNQYLQKITYGDNNSAVIDFGNADSAYVVMVNTKFQYTNSESPTLVQMAT LSSTGNKSVSTGNALGFTNNQSGGAGQEVYKIGNYVWEDTNKNGVQELGEKGVGNVTVTV FDNNTNTKVGEAVTKEDGSYLIPNLPNGDYRVEFSNLPKGYEVTPSKQGNNEELDSNGLS SVITVNGKDNLSADLGIYKPKYNLGDYVWEDTNKNGIQDQDEKGISGVTVTLKDENGNVL KTVTTDADGKYKFTDLDNGNYKVEFTTPEGYTPTTVTSGSDIEKDSNGLTTTGVINGADN MTLDSGFYKTPKYNLGNYVWEDTNKDGKQDSTEKGISGVTVTLKNENGEVLQTTKTDKDG KYQFTGLENGTYKVEFETPSGYTPTQVGSGTDEGIDSNGT STTGVIKDKDNDTIDSGFYK PTYNLGDYVWEDTNKNGVQDKDEKGISGVTVTLKDENDKVLKTVTTDENGKYQFTDLNNG TYKVEFETPSGYTPTSVTSGNDTEKDSNGLTTTGVIKDADNMTLDSGFYKTPKYSLGDYV WYDSNKDGKQDSTEKGIKDVKVTLLNEKGEVIGTTKTDENGKYCFDNLDSGKYKVIFEKP AGLTQTGTNTTEDDKDADGGEVDVTITDHDDFTLDNGYYEEETSDSDSDSDSDSDSDRDS DSDSDSDSDSDSDSDSDSDSDSDSDSDRDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDAGKHT PVKPMSTTKDHHNKAKALPETGNENSGSNNATLFGGLFAALGSLLLFGRRKKQNK 125. ttggcaggtcaagttgtccaatatggaagacatcgtaaacgtagaaactacgcgagaatt tcagaagtattagaattaccaaacttaatagaaattcaaactaaatcttacgagtggttc ctaagagaaggtttaatcgaaatgtttagagacatttctccaattgaagattttactggt aatttgtcattagagtttgtggattaccgtttaggagaaccaaaatatgatttagaagaa tctaaaaaccgtgacgctacttatgctgcacctcttcgtgtaaaagtgcgtctaatcatt aaagaaacaggagaagttaaagaacaagaagtctttatgggtgatttcccattaatgact gatacaggtacgttcgttatcaatggtgcagaacgtgtaatcgtatctcaattagttcgt tcaccatccgtttatttcaatgaaaaaatcgacaaaaatggtcgtgaaaactatgatgca acaattattccaaaccgtggtgcatggttagaatatgaaacagatgctaaagatgttgta tac gtacgtattgatagaacacgtaaactaccattaacagtattgttacgtgcattaggt ttctcaagcgaccaagaaattgttgaccttttaggtgacaatgaatatttacgtaatact ttagagaaagacggcactgaaaacactgaacaagcgttattagaaatctatgaacgttta cgtccaggtgaaccaccaactgttgaaaatgctaaaagtctattgtattcacgtttcttt gatccaaaacgctatgacttagcaagcgtgggtcgttataaaacaaacaaaaaattacat ttaaaacatcgtttatttaatcaaaaattagctgagccaattgtaaatactgaaactggt gaaattgtagttgaagaaggtacagtgcttgatcgtcgtaaaatcgacgaaatcatggat gtacttgaatcaaatgcaaacagcgaagtgtttgaattgcatggtagcgttatagacgag ccagtagaaattcaatcaattaaagtatatgttcctaacgatgatgaaggtcgtacgaca actgtaattggtaatgctttccctgactcagaagttaaatgcattacaccagcagatatc attgcttcaatgagttacttctttaacttattaagcggtattggatatacagatgatatt gaccatttaggtaaccgtcgtttacgttctgtaggtgaattactacaaaaccaattccgt atcggtttatcaagaatggaaagagttgtacgtgaaagaatgtcaattcaagatactgag tctatcacacctcaacaattaattaatattcgacctgttattgcatctattaaagaattc tttggtagctctcaattatcacaattcatggaccaagcaaacccattagctgagttaacg cataaacgtcgtctatcagcattaggacctggtggtttaacacgtgaacgtgctcaaatg gaagtacgtgacgttcactactctcac tatggccgtatgtgtccaattgaaacacctgag ggaccaaacattggattgattaactcattatcaagttatgcacgtgtaaatgaattcggc tttattgaaacaccatatcgtaaagttgatttagatacacatgctatcactgatcaaatt gactatttaacagctgacgaagaagatagctatgttgtagcacaagcaaactctaaatta gatgaaaatggtcgtttcatggatgatgaagttgtatgtcgtttccgtggtaacaataca gttatggctaaagaaaaaatggattatatggatgtatcgccgaagcaagttgtttcagca gcgacagcatgtattccattcttagaaaatgatgactcaaaccgtgcattgatgggtgcg aacatgcaacgtcaagcagtgcctttgatgaatccagaagcaccatttgttggtacaggt atggaacacgttgcagcacgtgattctggtgcggctattacagctaagcacagaggtcgt gttgaacatgttgaatctaatgaaattcttgttcgtcgtctagttgaagagaacggcgtt gagcatgaaggtgaattagatcgctatccattagctaaatttaaacgttcaaactcaggt acatgttacaaccaacgtccaatcgttgcagttggagatgttgttgagtataacgagatt ttagcagatggaccatctatggaattaggagaaatggcattaggtagaaacgtagtagtt ggtttcatgacttgggacggttacaactatgaggatgccgttatcatgagtgaaagactt gtgaaagatgacgtgtatacttctattcatattgaagagtatgaatcagaagtacgtgat actaagttaggacctgaagaaatcacaagagatattcctaatgtttctgaaagtgcactt aagaacttagacgatcgtggtatcgtttatattggtgcagaagtaaaagat ggagatatt ttagttggtaaagtaacgcctaaaggtgtaactgagttaactgccgaagaaagattgtta catgcaatctttggtgaaaaagcacgtgaagttagagatactttattacgtgtacctcac ggcgctggcggtatcgttcttgatgtaaaagtattcaatcgtgaagaaggcgacgataca ttatcacctggtgtaaaccaattagtacgtgtatatatcgttcaaaaacgtaaaattcat gttggtgataagatgtgtggtcgacatggtaacaaaggtgtcatttctaagattgttcct gaagaagatatgccttacttaccagatggacgtccgatcgatatcatgttaaatcctctt ggtgtaccatctcgtatgaacatcggacaagtattagagctacacttaggtatggctgct aaaaatcttggtattcacgttgcatcaccagtatttgacggtgcaaacgatgacgatgta tggtcaacaattgaagaagctggtatggctcgtgatggtaaaactgtactttatgatgga cgtacaggtgaaccattcgataaccgtatttcagtaggtgtaatgtacatgttgaaactt gcgcacatggttgatgataaattacatgcgcgttcaacaggaccatattcacttgttaca caacaaccacttggcggtaaagcgcaattcggtggacaacgttttggtgagatggaggta tgggcacttgaagcatatggtgctgcatacacattacaagaaatcttaacttacaaatcc gatgatacagtaggacgtgtgaaaacatacgaggctattgttaaaggtgaaaacatctct agaccaagtgttccagaatcattccgagtattgatgaaagaattacaaagtttaggttta gatgtaaaagttatggatgagcaagataatgaaatcgaaatgacagacgttgatgacgat gatgttgtagaacg caaagtagatttacaacaaaatgatgctcctgaaacacaaaaagaa gttactgat 126. MAGQVVQYGRHRKRRNYARISEVLELPNLIEIQTKSYEWFLREGLIEMFRDISPIEDFTG NLSLEFVDYRLGEPKYDLEESKNRDATYAAPLRVKVRLIIKETGEVKEQEVFMGDFPLMT DTGTFVINGAERVIVSQLVRSPSVYFNEKIDKNGRENYDATIIPNRGAWLEYETDAKDVV YVRIDRTRKLPLTVLLRALGFSSDQEIVDLLGDNEYLRNTLEKDGTENTEQALLEIYERL RPGEPPTVENAKSLLYSRFFDPKRYDLASVGRYKTNKKLHLKHRLFNQKLAEPIVNTETG EIVVEEGTVLDRRKIDEIMDVLESNANSEVFELHGSVIDEPVEIQSIKVYVPNDDEGRTT TVIGNAFPDSEVKCITPADIIASMSYFFNLLSGIGYTDDIDHLGNRRLRSVGELLQNQFR IGLSRMERVVRERMSIQDTESITPQQLINIRPVIASIKEFFGSSQLSQFMDQANPLAELT HKRRLSALGPGGLTRERAQMEVRDVHYSHYGRMCPIETPEGPNIGLINSLSSYARVNEFG FIETPYRKVDLDTHAITDQIDYLTADEEDSYVVAQANSKLDENGRFMDDEVVCRFRGNNT VMAKEKMDYMDVSPKQVVSAATACIPFLENDDSNRALMGANMQRQAVPLMNPEAPFVGTG MEHVAARDSGAAITAKHRGRVEHVESNEILVRRLVEENGVEHEGELDRYPLAKFKRSNSG TCYNQRPIVAVGDVVEYNEILADGPSMELGEMALGRNVVVGFMTWDGYNYEDAVIMSERL VKDDVYTSIHIEEYESRRQRDTKLGPEEITRDIPNVSESALKNLDDRGIVYIGAEVKDGD ILVGKVTPKGVTELTAEERLLHAIFGEKAREVRDTSLRVPHGAGGIVLDVKVFNREEGDD TLSPGVNQLVRVYIVQKRKIHVG DKMCGRHGNKGVISKIVPEEDMPYLPDGRPIDIMLNP LGVPSRMNIGQVLELHLGMAAKNLGIHVASPVFDGANDDDVWSTIEEAGMARDGKTVLYD GRTGEPFDNRISVGVMYMLKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEME VWALEAYGAAYTLQEILTYKSDDTVGRVKTYEAIVKGENISRPSVPESFRVLMKELQSLG LDVKVMDEQDNEIEMTDVDDDDVVERKVDLQQNDAPETQKSY 127. atgcttagggcatcgccatatctatcgtatttattcagtaatataaactggaaggagaaa aaatacatggctagagaattttcattagaaaaaactcgtaatatcggtatcatggctcac attgatgctggtaaaacgactacgactgaacgtattctttattacactggccgtatccac aaaattggtgaaacacacgaaggtgcttcacaaatggactggatggagcaagaacaagac cgtggtattactatcacatctgctgcaacaacagcagcttgggaaggtcaccgtgtaaac attatcgatacacctggacacgtagacttcactgtagaagttgaacgttcattacgtgta cttgacggagcagttacagtacttgatgcacaatcaggtgttgaacctcaaactgaaaca gtttggcgtcaggctacaacttatggtgttccacgtatcgtatttgtaaacaaaatggac aaattaggtgctaacttcgaatactctgtaagtacattacatgatcgtttacaagctaac gctgctccaatccaattaccaattggtgcggaagacgaattcgaagcaatcattgactta gttgaaatgaaatgtttcaaatatacaaatgatttaggtactgaaattgaagaaattgaa attcctgaagaccacttagatagagctgaagaagctcgtgctagcttaatcgaagcagtt gcagaaactagcgacgaattaatggaaaaatatcttggtgacgaagaaatttcagtttct gaattaaaagaagctatccgccaagctactactaacgtagaattctacccagtactttgt ggtacagctttcaaaaacaaaggtgttcaattaatgcttgacgctgtaattgattactta ccttcaccactagacgttaaaccaattattggtcaccgtgctagcaaccctgaagaagaa gtaatcgcgaaagcagacgattcagctgaattcgctgcattagcgttcaaagttatgact gacccttatgttggtaaattaacattcttccgtgtgtattcaggtacaatgacatctggt tcatacgttaagaactctactaaaggtaaacgtgaacgtgtaggtcgtttattacaaatg cacgctaactcacgtcaagaaatcgatactgtatactctggagatatcgctgctgcggta ggtcttaaagatacaggtactggtgatactttatgtggtgagaaaaatgacattatcttg gaatcaatggaattcccagagccagttattcacttatcagtagagccaaaatctaaagct gaccaagataaaatgactcaagctttagttaaattacaagaagaagacccaacattccat gcacacactgacgaagaaactggacaagttatcatcggtggtatgggtgagcttcactta gacatcttagtagaccgtatgaagaaagaattcaacgttgaatgtaacgtaggtgctcca atggtttcatatcgtgaaacattcaaatcatctgcacaagttcaaggtaaattctctcgt caatctggtggtcgtggtcaatacggtgatgttcacattgaattcacaccaaacgaaaca ggcgcaggtttcgaattcgaaaacgctatcgttggtggtgtagttcctcgtgaatacatt ccatcagtagaagctggtcttaa agatgctatggaaaatggtgttttagcaggttatcct ttaattgatgttaaagctaaattatatgatggttcataccatgatgtcgattcatctgaa atggccttcaaaattgctgcatcattagcacttaaagaagctgctaaaaaatgtgatcct gtaatcttagaaccaatgatgaaagtaactattgaaatgcctgaagagtacatgggtgat atcatgggtgacgtaacatctcgtcgtggacgtgttgatggtatggaacctcgtggtaat gcacaagttgttaatgcttatgtaccactttcagaaatgttcggttatgcaacatcatta cgttcaaacactcaaggtcgcggtacttacactatgtacttcgatcactatgctgaagtt ccaaaatcaatcgctgaagatattatcaagaaaaataaaggtgaa 128. MAREFSLEKTRNIGIMAHIDAGKTTTTERILYYTGRIHKIGETHEGASQMDWMEQEQDRG ITITSAATTAAWEGHRVNIIDTPGHVDFTVEVERSLRVLDGAVTVLDAQSGVEPQTETVW RQATTYGVPRIVFVNKMDKLGANFEYSVSTLHDRLQANAAPIQLPIGAEDEFEAIIDLVE MKCFKYTNDLGTEIEEIEIPEDHLDRAEEARASLIEAVAETSDELMEKYLGDEEISVSEL KEAIRQATTNVEFYPVLCGTAFKNKGVQLMLDAVIDYLPSPLDVKPIIGHRASNPEEEVI AKADDSAEFAALAFKVMTDPYVGKLTFFRVYSGTMTSGSYVKNSTKGKRERVGRLLQMHA NSRQEIDTVYSGDIAAAVGLKDTGTGDTLCGEKNDIILESMEFPEPVIHLSVEPKSKADQ DKMTQALVKLQEEDPTFHAHTDEETGQVIIGGMGELHLDILVDRMKKEFNVECNVGAPMV SYRETFKSSAQVQGKFSRQSGGRGQYGDVHIEFTPNETGAGFEFENAIVGGVVPREY IPS VEAGLKDAMENGVLAGYPLIDVKAKLYDGSYHDVDSSEMAFKIAASLALKEAAKKCDPVI LEPMMKVTIEMPEEYMGDIMGDVTSRRGRVDGMEPRGNAQVVNAYVPLSEMFGYATSLRS NTQGRGTYTMYFDHYAEVPKSIAEDIIKKNKGE 129. atgactaaaaaagtagcaattattctagcaaacgaatttgaagatatagaatattcaagc cctaaagaggcattagagaatgcaggctttaatactgtagtgattggagatactgcaaat agtgaagttgttggtaaacacggtgaaaaagttactgtcgatgtaggcattgcagaagct aaaccagaagattatgatgcattattaattcctggaggattttcaccagatcatttacgt ggagatacagaaggtcgatatggcacatttgctaaatactttactaaaaatgatgtacca acatttgccatttgtcatgggccacaaatactaatagatacagacgatttaaaaggtcgt acgttaacagcagtattaaatgtacgcaaagatttatcaaatgcaggcgcacatgtagtt gatgagtcagtagttgtagacaacaatattgtaacaagtcgagtaccagacgatttagat gattttaatcgagaaatcgttaaacaattacaa 130. MTKKVAIILANEFEDIEYSSPKEALENAGFNTVVIGDTANSEVVGKHGEKVTVDVGIAEA KPEDYDALLIPGGFSPDHLRGDTEGRYGTFAKYFTKNDVPTFAICHGPQILIDTDDLKGR TLTAVLNVRKDLSNAGAHVVDESVVVDNNIVTSRVPDDLDDFNREIVKQLQ 131. atggctaatcatgaacaaatcattgaagcgattaaagaaatgtcagtattagaattaaac gacttagtaaaagcaattgaagaagaatttggtgtaactgcagctgctccagtagcagta gcaggtg cagctggtggcgctgacgctgcagcagaaaaaactgaatttgacgttgagtta acttcagctggttcatctaaaatcaaagttgttaaagctgttaaagaagcaactggttta ggattaaaagatgctaaagaattagtagacggagctcctaaagtaatcaaagaagcttta cctaaagaagaagctgaaaaacttaaagaacaattagaagaagttggagctactgtagaa ttaaaa 132. MANHEQIIEAIKEMSVLELNDLVKAIEEEFGVTAAAPVAVAGAAGGADAAAEKTEFDVEL TSAGSSKIKVVKAVKEATGLGLKDAKELVDGAPKVIKEALPKEEAEKLKEQLEEVGATVE LK 133. gtggaattacaattagcaattgatttattaaacaaagaagacgcggctgagttagcaaat aaagtaaaagattatgtagatatcgtagaaatcggtacgccaatcatttacaacgaaggt ttaccagcagttaaacatatggcagacaacattagtaatgtaaaagtattagcagacatg aaaattatggatgcagctgattatgaagttagccaagcaattaaatttggcgcggatgta attacaatactaggtgttgcagaagatgcatcaattaaagcagctattgaagaagctcat aaaaataataaacaattactagttgatatgattgctgttcaagatttagaaaaacgtgca aaagaactagatgaaatgggtgctgattatattgcagtacacactggttatgatttacaa gcagaagggcaatcaccattagaaagtttaagaaccgttaaatctgttattaaaaattct aaagttgcagtagcaggtggaattaaaccagatacaattaaagatattgtcgctgaaagt cctgatcttgttattgttggtggcggaatcgcaaatgcagatgatccagtagaagctgca aaacaatgtcg cgctgcaatcgaaggtaag 134. MELQLAIDLLNKEDAAELANKVKDYVDIVEIGTPIIYNEGLPAVKHMADNISNVKVLADM KIMDAADYEVSQAIKFGADVITILGVAEDASIKAAIEEAHKNNKQLLVDMIAVQDLEKRA KELDEMGADYIAVHTGYDLQAEGQSPLESLRTVKSVIKNSKVAVAGGIKPDTIKDIVAES PDLVIVGGGIANADDPVEAAKQCRAAIEGK 135. atgaaaaaattagtacctttattattagccttattacttctagttgctgcatgtggtact ggtggtaaacaaagcagtgataagtcaaatggcaaattaaaagtagtaacgacgaattca attttatatgatatggctaaaaatgttggtggagacaacgtcgatattcatagtattgta cctgttggtcaagatcctcatgaatatgaagttaaacctaaagatattaaaaagttaact gacgctgacgttattttatacaacggattaaatttagagactggtaacggttggtttgaa aaagccttagaacaggctggtaaatcattaaaagataaaaaagttatcgcagtatcaaaa gatgttaaacctatctatttaaacggtgaagaaggcaacaaagataaacaagatccacac gcatggttaagtttagataacggtattaaatacgtaaaaacaattcaacaaacatttatc gataacgacaaaaaacataaagcagattatgaaaagcaaggtaacaaatacattgctcaa ttggaaaaattaaataatgacagtaaagacaaatttaatgacattccaaaagaacaacgt gccatgattacaagtgaaggtgccttcaagtacttctcaaaacaatacggtattacacca ggttatatttgggaaattaacactgaaaaacaaggtacacctgaacaaatgagacaagct attgagtttgttaaaaagcacaaa ttaaaacacttattagtagaaacaagtgttgataag aaagcaatggaaagtttatctgaagaaacgaagaaagatatctttggtgaagtgtacaca gattcaatcggtaaagaaggcactaaaggtgactcttactacaaaatgatgaaatcaaat attgaaactgtacacggaagcatgaaa 136. MKKLVPLLLALLLLVAACGTGGKQSSDKSNGKLKVVTTNSILYDMAKNVGGDNVDIHSIV PVGQDPHEYEVKPKDIKKLTDADVILYNGLNLETGNGWFEKALEQAGKSLKDKKVIAVSK DVKPIYLNGEEGNKDKQDPHAWLSLDNGIKYVKTIQQTFIDNDKKHKADYEKQGNKYIAQ LEKLNNDSKDKFNDIPKEQRAMITSEGAFKYFSKQYGITPGYIWEINTEKQGTPEQMRQA IEFVKKHKLKHLLVETSVDKKAMESLSEETKKDIFGEVYTDSIGKEGTKGDSYYKMMKSN IETVHGSMK 137. atgacaactgatattttgaacatttctgaagaacaacttgttgattattctaaagcccac aatgaaccttcttggatgacagaattacgtaaaaaagctttgaaattaacagaaacttta gaaatgccaaaacctgataaaacaaaattaagaaaatgggattttgattcttttaaacaa cacgatgtaaaaggtgatgtttatcaatctttatcacaattacctgagtcagtaagagaa attattgacgtagatcattctaaaaacttagtaattcaacataataatacgattgcgtac acacaagttgatgataatgcatcgaaagatggcgttatcgttgaaggtttagcagacgct cttatgaaccatagtgatttagtacaaaagtactttatgaaagatgcagtaacagtagat gaacatcgtatcacagcgctacacacggcattagttaatggtggcgtatttgtttatgtt cctaaaaatgtagttgtagaacatccagtacaatacgttgtgttgcacgacgacgaaaat gcaagcttttataaccatgttatcatcgttactgaagaaagcgccgaagtcacatatgtt gaaaattacttatcaaatgcatctggtgaaggaaatcaattaaatattatttctgaagtg attgctggtgcaaattcaaatatcacatatggctcagtggactatatggataaaggcttt acaggtcatatcattcgacgtggtattactgaagcggatgcctcaattaattgggcacta ggtttaatgaatgagggtagccaaattattgataatacaacaaatttatttggtgatcgt tcaacaagttcacttaaatcagtagttgtaggtacaggcgaacaaaaaattaatctaaca tctaaaatcgtacaatatggtaaagaaacagatggttatatccttaaacatggtgttatg aaagaacatgcatcgtctgtatttaatggtatcggctacattaagcatggtggaactaaa tcaattgctaatcaggaatcacgtgtattaatgttatctgaacatgctcgtggtgacgcg aatcctattttattaattgatgaagatgatgtacaagctggtcatgctgcatcagtaggt cgtgttgatccagatcaactttactatttaatgagtcgtggtatttctcaaagagaagcg gaacgtcttgttatacatggtttcttagatccagtagtacgtgaattacctatcgaagac gttaaacgtcaattgagagaagtaattgaacgcaaagtttctaaa 138. MTTDILNISEEQLVDYSKAHNEPSWMTELRKKALKLTETLEMPKPDKTKLRKWDFDSFKQ HDVKGDVYQSLSQLPESVREIIDVDHSKNLVIQHNNTIAYTQVDDNASKDGVIVEGLADA LMNHSDLVQKYFMKDAVTVDEHRITALHTALVNG GVFVYVPKNVVVEHPVQYVVLHDDEN ASFYNHVIIVTEESAEVTYVENYLSNASGEGNQLNIISEVIAGANSNITYGSVDYMDKGF TGHIIRRGITEADASINWALGLMNEGSQIIDNTTNLFGDRSTSSLKSVVVGTGEQKINLT SKIVQYGKETDGYILKHGVMKEHASSVFNGIGYIKHGGTKSIANQESRVLMLSEHARGDA NPILLIDEDDVQAGHAASVGRVDPDQLYYLMSRGISQREAERLVIHGFLDPVVRELPIED VKRQLREVIERKVSK 139. gtggttcaagaatatgatgtaatcgttataggtgcgggacatgcaggtgtagaagcaggt ttagcatctgcaagacgtggtgctaaaacattaatgctaacaataaatttagataatatt gcatttatgccatgtaacccatctgtaggtggaccagctaaaggtatcgttgttcgtgaa attgatgctttaggtggacaaatggcaaaaacaatcgataaaacacacattcaaatgaga atgttaaatacaggtaaaggacctgctgtaagagcactaagagcgcaagcagataaagta ctttatcaacaagaaatgaaacgcgtgattgaagatgaagaaaatttgcatataatgcaa ggtatggtagacgaacttattatagaagataatgaagttaaaggtgtacgtacaaatatt ggtacagagtatttatctaaagcagtaattattacaacgggaacatttttacgtggtgaa atcattttaggtaatatgaagtattcaagtggaccaaatcaccaattaccatcaatcaca ttatcagacaatttaagagaacttggttttgatattgttcgttttaaaacaggtacacca ccgcgtgtaaattcaaaaacaattgactattcgaagactgaaatacaaccaggtgacgat gtaggtcgtgcattcagctttgaaacaacagaatata tattagatcaattgccatgttgg ctaacgtatactaatgctgaaacacacaaagttatcgatgataatttacatctatctgca atgtattcagggatgattaaaggaaccgggccacgttattgcccttcaattgaagataaa tttgttcgatttaatgataagccgcgacatcaacttttcttagagcctgaaggtcgtaat acaaatgaagtatatgtgcaaggattgtctacaagtcttcctgaacatgtgcaacgtcaa atgttagagacgataccaggtcttgaaaaagcagatatgatgcgtgccggctacgcaatt gaatatgatgcgattgtgccaacgcagttatggcctacacttgaaacgaaaatgattaaa aacttatatactgcaggtcaaattaatggtacatctggttatgaagaagcagcaggacaa ggattgatggcaggtattaacgctgcaggtaaagtgttaaacacaggcgaaaagatatta agtcgttcagatgcatatattggtgtcttaatcgatgatcttgtaactaaaggtactaat gaaccttatcgtttactaacatcacgtgcagaatatcgtttgttactacgtcatgataat gctgatttgagattgacggatatgggatatgaacttggtatgatttctgaagaaagatat gcacgttttaatgaaaaacgtcagcaaattgatgcggaaattaagcgtttatcagatatt cgtattaaaccaaacgaacatacgcaagcgattattgaacaacatggtggttctcgctta aaagatggtattttagctatcgatttattacgcagacctgaaatgacttacgatataatt ttagaacttttagaagaagaacatcaattgaatgcagatgttgaagaacaagtagaaata caaacaaaatatgaaggttatatcaataaatcactacaacaagttgagaaagttaagcgt atggaagagaagaaaattccagaagacttagattatagtaagattgatagtttggcgact gaagcgcgagaaaaattatcagaagtaaaacctttaaatattgcacaagcttctagaata tcaggggtaaatccagcagacatatctatattattgatttacttagaacaaggtaaactc caaagggtgagtgac 140. MVQEYDVIVIGAGHAGVEAGLASARRGAKTLMLTINLDNIAFMPCNPSVGGPAKGIVVRE IDALGGQMAKTIDKTHIQMRMLNTGKGPAVRALRAQADKVLYQQEMKRVIEDEENLHIMQ GMVDELIIEDNEVKGVRTNIGTEYLSKAVIITTGTFLRGEIILGNMKYSSGPNHQLPSIT LSDNLRELGFDIVRFKTGTPPRVNSKTIDYSKTEIQPGDDVGRAFSFETTEYILDQLPCW LTYTNAETHKVIDDNLHLSAMYSGMIKGTGPRYCPSIEDKFVRFNDKPRHQLFLEPEGRN TNEVYVQGLSTSLPEHVQRQMLETIPGLEKADMMRAGYAIEYDAIVPTQLWPTLETKMIK NLYTAGQINGTSGYEEAAGQGLMAGINAAGKVLNTGEKILSRSDAYIGVLIDDLVTKGTN EPYRLLTSRAEYRLLLRHDNADLRLTDMGYELGMISEERYARFNEKRQQIDAEIKRLSDI RIKPNEHTQAIIEQHGGSRLKDGILAIDLLRRPEMTYDIILELLEEEHQLNADVEEQVEI QTKYEGYINKSLQQVEKVKRMEEKKIPEDLDYSKIDSLATEAREKLSEVKPLNIAQASRI SGVNPADISILLIYLEQGKLQRVSD 141. LMINEREVFILIYLDNAAXTKAFEEVLDTYLKVNQSMYYNPNSPHKAGLQANQLLQQAKT QINAMINSKTNYDVVFTSGATESNNLALKGIAYRKFDTAKEIITSVLEHPSVLEVVRYLE AHEGFKVKYVDVKKDGSINLEHFKELMSDKVGL VTCMYVNNVTGQIQPIPQMAKVIKNYP KAHFHVDAVQAFGKISMDLNNIDSISLSGHKFNGLKGQGVLLVNHIQNVEPTVHGGGQEY GVRSGTVNLPNDIAMVKAMKIANENFEALNAFVTELNNDVRQFLNKYHGVYINSSTSGSP FVLNISFPGVKGEVLVNAFSKYDIMISTTSACSSKRNKLNEVLAAMGLSDKSIEGSIRLS FGATTTKEDIARFKEIFIIIYEEIKELLK 142. MNKQQKEFKSFYSIRKSSLGVASVAISTLLLLMSNGEAQAAAEETGGTNTEAQPKTEAVA SPTTTSEKAPETKPVANAVSVSNKEVEAPTSETKEAKEVKEVKAPKETKEVKPAAKATNN TYPILNQELREAIKNPAIKDKDHSAPNSRPIDFEMKKKDGTQQFYHYASSVKPARVIFTD SKPEIELGLQSGQFWRKFEVYEGDKKLPIKLVSYDTVKDYAYIRFSVSNGTKAVKIVSST HFNNKEEKYDYTLMEFAQPIYNSADKFKTEEDYKAEKLLAPYKKAKTLERQVYELNKIQD KLPEKLKAEYKKKLEDTKKALDEQVKSAITEFQNVQPTNEKMTDLQDTKYVVYESVENNE SMMDTFVKHPIKTGMLNGKKYMVMETTNDDYWKDFMVEGQRVRTISKDAKNNTRTIIFPY VEGKTLYDAIVKVHVKTIDYDGQYHVRIVDKEAFTKANTDKSNKKEQQDNSAKKEATPAT PSKPTPSPVEKESQKQDSQKDDNKQLPSVEKENDASSESGKGVTLATKPTKGEVESSSTT PTKVVSTTQNVAKPTTGSSKTTKDVVQTSAGSSEAKDSAPLQKANIKHTNDGHTQSQNNK NTQENKAKSLPQTGEESNKDMTLPLMALLALSSIVAFVLPRKRKN 143. atgagctggtttgataaattattcggcgaagataatgattcaaatgatgacttgattcat agaaagaaaaaaagacgtcaagaatcacaaaa tatagataacgatcatgactcattactg cctcaaaataatgatatttatagtcgtccgaggggaaaattccgttttcctatgagcgta gcttatgaaaatgaaaatgttgaacaatctgcagatactatttcagatgaaaaagaacaa taccatcgagactatcgcaaacaaagccacgattctcgttcacaaaaacgacatcgccgt agaagaaatcaaacaactgaagaacaaaattatagtgaacaacgtgggaattctaaaata tcacagcaaagtataaaatataaagatcattcacattaccatacgaataagccaggtaca tatgtttctgcaattaatggtattgagaaggaaacgcacaagccaaaaacacataatatg tattctaataatacaaatcatcgtgctaaagattcaactccagattatcacaaagaaagt ttcaagacttcagaggtaccgtcagctatttttggcacaatgaaacctaaaaagttagaa aatggtcgtatccctgtaagtaaaccttcagaaaaagttgagtcagataaacaaaaatat gataaatatgtagctaagacgcaaacgtctcaaaataaacaattagaacaagaaaaacaa aatgatagtgttgtcaaacaaggaactgcatctaaatcatctgatgaaaatgtatcatca acaacaaaatcaatgcctaattattcaaaagttgataatactatcaaaattgaaaatatt tatgcttcacaaattgttgaagaaattagacgtgaacgagaacgtaaagtgcttcaaaag cgtcgatttaaaaaagcgttgcaacaaaagcgtgaagaacataaaaacgaagagcaagat gcaatacaacgtgcaattgatgaaatgtatgctaaacaagcggaacgctatgttggtgat agttcattaaatgatgatagtgacttaacagataatagtacagatgctagtcagct tcat acaaatggcatagagaatgaaactgtatcaaatgatgaaaataaacaagcgtcaatacaa aatgaagacactaatgacactcatgtagatgaaagtccatacaattatgaggaagttagt ttgaatcaagtatcgacaacaaaacaattgtcagatgatgaagttacggtttcgaatgta acgtctcaacatcaatcagcactacaacataacgttgaagtaaatgataaagatgaacta aaaaatcaatccagattaattgctgattcagaagaagatggagcaacgaataaagaagaa tattcaggaagtcaaatcgatgatgcagaattttatgaattaaatgatacagaagtagat gaggatactacttcaaatatcgaagataataccaatagaaacgcgtctgaaatgcatgta gacgctcctaaaacgcaagagtacgcagtaactgaatctcaagtaaataatatcgataaa acggttgataatgaaattgaattagcaccgcgtcataaaaaagatgaccaaacaaactta agtgtcaactcattgaaaacgaatgatgtgaatgataatcatgttgtggaagattcaagc atgaatgaaatagaaaagaataacgcagaaattacagaaaatgtgcaaaacgaagcagct gaaagtgaacaaaatgtcgaagagaaaactattgaaaacgtaaatccaaagaaacagact gaaaaggtttcaactttaagtaaaagaccatttaatgttgtcatgacgccatctgataaa aagcgtatgatggatcgtaaaaagcattcaaaagtcaatgtgcctgaattaaagcctgta caaagtaagcaagctgtgagtgaaagaatgcctgcgagtcaagccacaccatcatcaaga tctgattcacaagagtcaaatacaaatgcatataaaacaaataatatgacatcaaacaat gttgagaacaatcaactta ttggtcatgcagaaacagaaaatgattatcaaaatgcacaa caatattcagagcagaaaccttctgttgattcaactcaaacggaaatatttgaagaaagt caagatgataatcaattggaaaatgagcaagttgatcaatcaacttcgtcttcagtttca gaagtaagcgacataactgaagaaagcgaagaaacaacacatccaaacaatactagtgga caacaagataatgatgatcaacaaaaagatttacagtcatcattttcaaataaaaatgaa gatacagctaatgaaaatagacctcggacgaaccaacaagatgttgcaacaaatcaagct gtacaaacatctaagccgatgattcgtaaaggcccaaatattaaattgccaagtgtttca ttactagaagaaccacaagttattgagtcggacgaggactggattacagataaaaagaaa gaactgaatgacgcattattttactttaatgtacctgcagaagtacaagatgtaactgaa ggtccaagtgttacaagatttgaattatcagttgaaaaaggtgttaaagtttcaagaatt acggcattacaagatgacattaaaatggcattggcagcgaaagatattcgtatagaagcg cctattccaggaactagtcgtgttggtattgaagttccgaaccaaaatccaacgacagtc aacttacgttctattattgaatctccaagttttaaaaatgctgaatctaaattaacagtt gcgatggggtatagaattaataatgaaccattacttatggatattgctaaaacgccacac gcactaattgcaggtgcaactggatcagggaaatcagtttgtatcaatagtattttgatg tctttactatataaaaatcatcctgaggaattaagattattacttatcgatccaaaaatg gttgaattagctccttataatggtttgccacatttagttgcac cggtaattacagatgtc aaagcagctacacagagtttaaaatgggccgtagaagaaatggaacgacgttataagtta tttgcacattaccatgtacgtaatataacagcatttaacaaaaaagcaccatatgatgaa agaatgccaaaaattgtcattgtaattgatgagttggctgatttaatgatgatggctccg caagaagttgaacagtctattgctagaattgctcaaaaagcgagagcatgtggtattcat atgttagtagctacgcaaagaccatctgtcaatgtaattacaggtttaattaaagccaac ataccaacaagaattgcatttatggtatcatcaagtgtagattcgagaacgatattagac agtggtggagcagaacgcttgttaggatatggcgatatgttatatcttggtagcggtatg aataaaccgattagagttcaaggtacatttgtttctgatgacgaaattgatgatgttgtt gattttatcaaacaacaaagagaaccggactatctatttgaagaaaaagaattgttgaaa aaaacacaaacacaatcacaagatgaattatttgatgatgtttgtgcatttatggttaat gaaggacatatttcaacatcattaatccaaagacatttccaaattggctataatagagca gcaagaattatcgatcaattagagcaactcggttatgtttcgagtgctaatggttcaaaa ccaagggatgtttatgttacggaagcagatttaaataaagaa 144. atgcctaaacgtaatgatatcaaaacaattttagtaatagggtctgggccaattatcata ggtcaagcagctgaatttgattatgctggaacacaagcatgtctagctttaaaagaagag ggatatcgagttattcttgtaaattcaaatccagcgacaatcatgactgataaggaaatt gcggataaagtatatatcg aaccgttaactcatgattttatagcgcgaattatacgtaaa gagcaacctgacgctttacttccaactttaggtggtcaaacaggtttaaacatggcgatt caactacacgaaagtggtgtgcttcaagataataacgtccaattattaggaactgagcta acatcaattcaacaagcagaagaccgtgaaatgtttagaacattaatgaatgatttaaac gttcctgtaccagagagtgacattgtaaatacagtagagcaagcctttaaattcaaagag caagtgggatacccgctaattgttagaccggcatttacgatgggtggtaccggaggcggt atttgtcataatgatgaagaattacatgaaatcgtctcaaatggtcttcattatagtcca gcaacgcaatgtttattagaaaaatctatcgcaggttttaaagaaatcgaatacgaagta atgcgtgataaaaacgataatgccatcgttgtatgtaacatggaaaatattgatccagtt ggtattcatacaggcgattcaattgttgtggctcctagtcaaacattatcagatgttgag tatcaaatgttacgtgatgtttcattaaaagttattcgagctttaggtatcgaaggtggt tgtaatgttcaattagcattagatccccattcattcgattattatattatagaagtaaat ccgcgtgtatcacgttcatcagcgttagcttcaaaagcaacaggatatcctattgcaaaa ttagctgctaaaatcgcggttggtctaacattagatgaaatgttaaatccaattacagga acatcttatgcagcgtttgaaccaactttagactatgtgatttcaaaaataccaagattt ccttttgataaatttgaaaaaggagaacgagagcttggcacacaaatgaaagcaacaggt gaagttatggccattggtcgaacttacgaagaatcattgttaa aagcaattcgatcactt gagtatggtgtgcatcacttaggattaccaaatggtgaaagcttcgatcttgattatatt aaagaacgtatttcacaccaagatgatgaacgattatttttcatcggcgaagcaattaga agaggcacaacattagaagaaattcataatatgactcagattgattacttcttcttacac aagttccaaaacattattgatattgagcatcaattaaaagagcatcaaggtgatttagaa tatcttaaatatgcaaaagattatggatttagtgataaaacaatagcgcatcgctttaat atgacggaagaagaagtatatcaattgcgtatggaaaatgatattaaacctgtttacaag atggttgatacttgcgcagctgaatttgaatcttcaacaccatattattatggtacatac gaaactgaaaatgaatccatagttactgacaaagaaaaaatcttagtattaggctctgga ccaattcgaatcggccaaggtgtagaatttgactatgcgacagttcatgccgtttgggca attcaaaaagcagggtacgaagcgataattgtgaataacaatccagaaacagtttcaaca gacttctcaatttctgacaaattatactttgaacctttaactgaagaagatgtgatgaat atcattaatttagaaaaacctaaaggtgtcgttgtacaatttggaggacaaacagcgatt aatttagcagacaaattggctaaacatggtgttaaaatacttggtacttcactagaaaat ctaaatcgtgctgaagatagaaaagaatttgaagcactattaagaaaaattaacgtgcca cagccacaagggaaaacagctacatcacctgaggaagcattagcgaatgctgcagaaatc ggatatccggttgtagtaagaccttcttatgtattaggtggtcgcgcaatggaaattgta gacaat gacaaagagttagaaaactatatgacccaggctgtaaaagcgagtccggaacat ccggtactagtcgatagatatttaactggtaaagaaattgaagttgatgcgatttgtgat ggagaaacggtcattattccaggaatcatggaacatattgaacgtgctggtgtgcatagt ggtgactcaatcgctgtatatccaccacaaactttgacagaagacgagttagcaacactt gaggactatactataaaattagctaaaggtttaaacatcattggcttaatcaacattcaa ttcgttatagctcacgatggtgtgtatgttttagaagtaaatccacgttctagtagaacg gtaccattcttaagtaaaattactgatattccaatggcacaattagctatgcgagcaatc attggggaaaaactaacagatatgggttatcaagaaggggttcaaccatatgctgagggt gtctttgtgaaagcaccagtatttagttttaataaattgaaaaatgttgatattacttta ggacctgaaatgaagtcaacaggtgaagtgatggggaaagatactacattagaaaaggcg ttattcaaagggttaacaggtagtggcgttgaagttaaagatcacggtacagtattaatg accgtcagtgacaaagataaagaggaagttgttaaattggcacaacgcttaaatgaagtt ggctataaaattttagcaacgtctggaacagctaataaattagctgagtatgacatacct gcagaagtagtaggcaaaattggtggcgaaaatgatttattaacacgtattcaaaatggt gatgttcaaatcgttataaatacaatgactaaaggtaaagaagtagaaagggatggcttc caaattagacgtactacagttgaaaatggtattccatgtttgacatctttagatacagct aatgccttaacgaatgtaattgaaagtatg acatttacaatgcgtcaaatg 145. atgattaacagggataataaaaaggcaataacaaaaaagggtatgatttcaaatcgctta aacaaattttcgattagaaagtatactgtaggaactgcatcgattttagtaggtacgaca ttgatttttggtctagggaaccaagaagctaaagctgctgaaaacactagtacagaaaat gcaaaacaagatgatgcaacgactagtgataataaagaagtagtgtcggaaactgaaaat aattcgacaacagaaaataattcaacaaatccaattaagaaagaaacaaatactgattca caaccagaagctaaaaaagaatcaacttcatcaagtactcaaaaacagcaaaataacgtt acagctacaactgaaactaagcctcaaaacattgaaaaagaaaatgttaaaccttcaact gataaaactgcgacagaagatacatctgttattttagaagagaagaaagcaccaaataat acaaataacgatgtaactacaaaaccatctacaagtgaaccatctacaagtgaaattcaa acaaaaccaactacacctcaagaatctacaaatattgaaaattcacaaccgcaaccaacg ccttcaaaagtagacaatcaagttacagatgcaactaatccaaaagaaccagtaaatgtg tcaaaagaagaacttaaaaaaaatcctgagaaattaaaagaattggttagaaatgatagc aatacagatcattcaactaaaccagttgctacagctccaacaagtgttgcaccaaaacgt gtaaacgcaaaaatgcgctttgcagttgcacaaccagcagcagttgcttcaaacaatgta aatgatttaattaaagtgacgaagcaaacaatcaaagttggcgatggtaaagataatgtg gcagcagcgcatgacggtaaagatattgaatatgatacagagtttacaattgacaata aa gtcaaaaaaggcgatacaatgacgattaattatgataagaatgtaattccttcggattta acagataaaaatgatcctatcgatattactgatccatcaggagaggtcattgctaaagga acatttgataaagcaactaagcaaatcacatatacatttacagactatgtagataaatat gaagatataaaatcacgcttaactctatattcgtatattgataaaaaaacagttccaaat gagacaagtttgaatttaacatttgctacagcaggtaaagaaacaagccaaaatgtcact gttgattatcaagatccaatggtccatggtgattcaaacattcaatctatctttacaaaa ttagatgaagataagcaaactattgaacaacaaatttatgttaacccattgaaaaaatca gcaaccaacactaaagttgatatagctggtagtcaagtagatgattatggaaatattaaa ctaggaaatggtagcaccattattgaccaaaatacagaaataaaggtttataaagttaac tctgatcaacaattgcctcaaagtaatagaatctatgattttagtcaatacgaagatgta acaagtcaatttgataataaaaaatcatttagtaataatgtagcaacattggattttggt gatattaattcagcctatattatcaaagttgttagtaaatatacacctacatcagatggc gaactagatattgcccaaggtactagtatgagaacaactgataaatatggttattataat tatgcaggatattcaaacttcatcgtaacttctaatgacactggcggtggcgacggtact gttaaacctgaagaaaagttatacaaaattggtgactatgtatgggaagacgttgataaa gacggtgttcaaggtacagattcaaaagaaaaaccaatggcaaacgttttagttacatta acttacccggacggtactaca aaatcagtaagaacagatgctaatggtcattatgaattc ggtggtttgaaagacggagaaacttatacagttaaattcgaaacgccaactggatatctt ccaacaaaagtaaatggaacaactgatggtgaaaaagactcaaatggtagttcggttact gttaaaattaatggtaaagatgatatgtctttagatactggtttttacaaagaacctaaa tacaacttaggtgactatgtatgggaagatactaataaagatggtatccaagatgcaaat gagccaggaatcaaagatgttaaggttacattaaaagatagtactggaaaagttattggt acaactactactgatgcctcgggtaaatataaatttacagatttagataatggtaactat acagtagaatttgaaacaccagcaggttacacgccaacggttaaaaatactacagctgat gataaagattctaatggtttaacaacaacaggtgtcattaaagatgcagataatatgaca ttagacaggggtttctataaaacaccaaaatacagtttaggtgattatgtttggtacgac agtaataaagacggcaaacaagattcaactgaaaaaggtatcaaagatgtgacagttaca ttgcaaaacgaaaaaggcgaagtaattggaacaactaaaacagatgaaaatggtaaatat cgtttcgataatttagatagcggtaaatacaaagttatttttgaaaagcctgctggctta acacaaacagttacaaatacaactgaagatgataaagatgcagatggtggcgaagttgac gtaacaattacggatcatgatgatttcacacttgataacggatacttcgaagaagataca tcagacagcgattcagactcagatagtgactcagacagcgactcagactcagacagcgac tcagactcagacagtgattcagattcagacagcgactcagattca gatagcgactcagat tcggacagcgattcagactcagatagcgactcagattcagatagcgattcagactcagac agcgactcagattcagatagcgattcggactcagacagcgattcagactcagatagcgac tcagactcagacagcgactcagattcagatagcgattcggactcagatagcgactcagat tcagacagcgattcagactcagatagcgactcagattcagacagcgattcagactcagat agcgactcagactcagacagtgattcagattcagacagcgactcagactcagatagcgac tcagattcggacagcgactcagactcagatagcgactcagactcagacagtgattcagac agcgattcagactcggatgcaggaaaacatacacctgttaaaccaatgagtactactaaa gaccatcacaataaagcaaaagcattaccagaaacaggtagtgaaaataacggctcaaat aacgcaacgttatttggtggattatttgcagcattaggttcattattgttattcggtcgt cgcaaaaaacaaaacaaa 146. atgactcatttattagagacatttgagatgtcaatagatcaccaggaagatggtttagtt gttatttctatgcctgttactgataaagtaaaacaaccatttggatatttacatggtggg gcttcgattgctttaggtgaaacagcatgttcattaggatctgctaatttaattgataca accaaatttattccattaggtttagagatgaatgctaaccatattcattctgctaaagat ggtcgtgttactgcgacagctgaaattattcatcgaggtaagtcgacacatgtatgggat ataaaaattaagaatgacaaagaacaattaattacagttatgcgtggtacagttgctatt aaacctttaaaa 147. atggagcatacaactatgaaaataaca acgattgctaaaacaagtttagcactaggcctt ttaacaacaggtgtaatcacaacgacaacgcaagcagcaaacgcgacaacaccatcttcc actaaagtggaagcaccacaatcaacaccgccctcaactaaaatagaagcaccgcaatca aaaccaaacgcgacaacaccgccctcaactaaagtagaagcaccgcaacaaacagcaaat gcgacaacaccgccttcaactaaagtgacaacacctccatcaacaaacacgccacaacca atgcaatctactaaatcagacacaccacaatcgccaaccacaaaacaagtaccaacagaa ataaatcctaaatttaaagatttaagagcgtattatacgaaaccaagtttagaatttaaa aatgagattggtattattttaaaaaaatggacgacaataagatttatgaatgttgtccca gattatttcatatataaaattgctttagttggtaaagatgataaaaaatatggtgaagga gtacataggaatgtcgatgtatttgtcgttttagaagaaaataattacaatctggaaaaa tattctgtcggtggtatcacaaagagtaatagtaaaaaagttgatcacaaagcaggagta agaattactaaggaagataataaaggtacaatctctcatgatgtttcagaattcaagatt actaaagaacagatttccttgaaagaacttgattttaaattgagaaaacaacttattgaa aaaaataatctgtacggtaacgttggttcaggtaaaattgttattaaaatgaaaaacggt ggaaagtacacgtttgaattgcacaaaaaattacaagaaaatcgcatggcagatgtcatt aatagtgaacaaattaaaaacatcgaagtgaatttgaaa 148. atgaaaaagcaaataatttcgctaggcgcattagcagttgcatctagcttatttacatgg gataac aaagcagatgcgatagtaacaaaggattatagtgggaaatcacaagttaatgct gggagtaaaaatgggacattaatagatagcagatatttaaattcagctctatattatttg gaagactatataatttatgctataggattaactaataaatatgaatatggagataatatt tataaagaagctaaagataggttgttggaaaaggtattaagggaagatcaatatcttttg gagagaaagaaatctcaatatgaagattataaacaatggtatgcaaattataaaaaagaa aatcctcgtacagatttaaaaatggctaattttcataaatataatttagaagaactttcg atgaaagaatacaatgaactacaggatgcattaaagagagcactggatgattttcacaga gaagttaaagatattaaggataagaattcagacttgaaaacttttaatgcagcagaagaa gataaagcaactaaggaagtatacgatctcgtatctgaaattgatacattagttgtatca tattatggtgataaggattatggggagcacgcgaaagagttacgagcaaaactggactta atccttggagatacagacaatccacataaaattacaaatgaacgtattaaaaaagaaatg attgatgacttaaattcaattattgatgatttctttatggaaactaaacaaaatagaccg aaatctataacgaaatataatcctacaacacataactataaaacaaatagtgataataaa cctaattttgataaattagttgaagaaacgaaaaaagcagttaaagaagcagatgattct tggaaaaagaaaactgtcaaaaaatacggagaaactgaaacaaaatcgccagtagtaaaa gaagagaagaaagttgaagaacctcaagcacctaaagttgataaccaacaagaggttaaa actacggctggtaaagctgaagaaacaaca caaccagttgcacaaccattagttaaaatt ccacagggcacaattacaggtgaaattgtaaaaggtccggaatatccaacgatggaaaat aaaacggtacaaggtgaaatcgttcaaggtcccgattttctaacaatggaacaaagcggc ccatcattaagcaataattatacaaacccaccgttaacgaaccctattttagaaggtctt gaaggtagctcatctaaacttgaaataaaaccacaaggtactgaatcaacgttaaaaggt actcaaggagaatcaagtgatattgaagttaaacctcaagcaactgaaacaacagaagct tctcaatatggtccgagaccgcaatttaacaaaacacctaaatatgttaaatatagagat gctggtacaggtatccgtgaatacaacgatggaacatttggatatgaagcgagaccaaga ttcaataagccatcagaaacaaatgcatataacgtaacaacacatgcaaatggtcaagta tcatacggagctcgtccgacatacaagaagccaagcgaaacgaatgcatacaatgtaaca acacatgcaaacggccaagtatcatacggagctcgtccgacacaaaacaagccaagcaaa acaaacgcatataacgtaacaacacatggaaacggccaagtatcatatggcgctcgccca acacaaaacaagccaagcaaaacaaatgcatacaacgtaacaacacatgcaaacggtcaa gtgtcatacggagctcgcccgacatacaagaagccaagtaaaacaaatgcatacaatgta acaacacatgcagatggtactgcgacatatgggcctagagtaacaaaa 149. atgaaaaaattagcaacagtaggttctttaattgtaacaagcactttagtattctcaagt atgccttttcaaaatgcgcatgccgacacaacttcaatgaatgtgtcgaataaacaaagc caaaatgtacaaaatcatcgtccttatggcggagtagtaccacaaggaatgacgcaagca caatatactgaattagagaaagctttaccccaattaagcgctggcagtaatatgcaagac tataatatgaaattgtatgatgcgacgcaaaatattgctgataaatacaatgtgataatt acaactaatgtaggggtatttaaaccacatgctgttagagatatgaatggccatgcgtta cctttaacaaaagatggcaatttttatcaaacgaatgtagatgcaaatggtgttaatcat ggtggtagtgaaatggtgcaaaataaaacaggtcatatgagtcaacaaggccatatgaat cagaacacacacatgaaccaacagccacacatgcaacaaggtcatatgcaatcatcaaac catcaaatgatgagtccaaaagcaaatatgcattcatcaaatcatcaaatgaaccaaagt aacaaaaaagttttaccagctgctggtgaaagtatgacatcaagtattcttactgcaagt attgccgcactactattagtatctgggttattcttagcatttagacgacgttcaacaaat aaa 150. gtgcttaggagtgatttttatatgtcttattccattgttagagtttcaaaagttaaatct ggaacaaatacaacgggcatacaaaaacatgttcaaagagaaaataataattatgaaaat gaagatatagaccatagtaaaacttacttaaattatgatttggtaaatgctaataaacag aattttaataacttgattgatgaaaaaatcgaacagaattatacaggcaaaagaaaaatt agaacagacgcgattaaacacattgatggtttaattacatcagacaatgatttctttgat aatcaaacgccagaagatacaaagcagttttttgaatatgctaaagagtttttagaacaa gaatacggtaaagat aatttattatatgcaacagttcacatggacgaaaaaacaccacat atgcattatggcgttgttccaataactgatgatggtcgtttaagtgctaaagaagttgta ggtaataaaaaagctttaacagcgtttcaagatagatttaatgagcatgttaaacaacga ggatatgatttagaacgtgggcaatcaagacaagtaacaaatgctaaacatgagcaaata agtcagtataaacaaaaaacagaatatcataagcaagaatatgaacgtgagagccaaaaa acagaccatataaagcaaaagaacgataaattaatgcaagagtaccaaaaatcgttaaat acgcttaaaaagcctataaatgttccgtatgagcaagaaactgaaaaagtaggtggttta tttagcaaagaaatacaagaaactggaaatgttgtaataagccaaaaagatttcaatgaa tttcagaaacagataaaagctgctcaagatatttcggaagattacgagtatataaagtct ggtagagccttagatgataaagataaggaaatacgagagaaagatgatttattaaataaa gcagttgagcgtattgaaaacgcagacgataattttaaccaactttacgaaaatgcaaag ccacttaaagagaatatagaaatagcgttaaagcttttaaaaatcttactaaaagagtta gaacgagttttaggaagaaatacctttgcggaaagagttaataagttaacagaagatgaa cctatggca 151. MSWFDKLFGEDNDSNDDLIHRKKKRRQESQNIDNDHDSLLPQNNDIYSRPRGKFRFPMSV AYENENVEQSADTISDEKEQYHRDYRKQSHDSRSQKRHRRRRNQTTEEQNYSEQRGNSKI SQQSIKYKDHSHYHTNKPGTYVSAINGIEKETHKPKTHNMYSNNTNHRAKDSTPDYHKES FKTSEVPSAIFGTMKPKKLENGRI PVSKPSEKVESDKQKYDKYVAKTQTSQNKQLEQEKQ NDSVVKQGTASKSSDENVSSTTKSMPNYSKVDNTIKIENIYASQIVEEIRRERERKVLQK RRFKKALQQKREEHKNEEQDAIQRAIDEMYAKQAERYVGDSSLNDDSDLTDNSTDASQLH TNGIENETVSNDENKQASIQNEDTNDTHVDESPYNYEEVSLNQVSTTKQLSDDEVTVSNV TSQHQSALQHNVEVNDKDELKNQSRLIADSEEDGATNKEEYSGSQIDDAEFYELNDTEVD EDTTSNIEDNTNRNASEMHVDAPKTQEYAVTESQVNNIDKTVDNEIELAPRHKKDDQTNL SVNSLKTNDVNDNHVVEDSSMNEIEKNNAEITENVQNEAAESEQNVEEKTIENVNPKKQT EKVSTLSKRPFNVVMTPSDKKRMMDRKKHSKVNVPELKPVQSKQAVSERMPASQATPSSR SDSQESNTNAYKTNNMTSNNVENNQLIGHAETENDYQNAQQYSEQKPSVDSTQTEIFEES QDDNQLENEQVDQSTSSSVSEVSDITEESEETTHPNNTSGQQDNDDQQKDLQSSFSNKNE DTANENRPRTNQQDVATNQAVQTSKPMIRKGPNIKLPSVSLLEEPQVIESDEDWITDKKK ELNDALFYFNVPAEVQDVTEGPSVTRFELSVEKGVKVSRITALQDDIKMALAAKDIRIEA PIPGTSRVGIEVPNQNPTTVNLRSIIESPSFKNAESKLTVAMGYRINNEPLLMDIAKTPH ALIAGATGSGKSVCINSILMSLLYKNHPEELRLLLIDPKMVELAPYNGLPHLVAPVITDV KAATQSLKWAVEEMERRYKLFAHYHVRNITAFNKKAPYDERMPKIVIVIDELADLMMMAP QEVEQSIARIAQKARACGIHMLVATQRPSVNVITGLIKANIPTRIAFMVSSSVDSRTILD SGGAERLLGYGDMLYLGSGMNKPIRVQGTFVSDDEIDDVVDFIKQQRE PDYLFEEKELLK KTQTQSQDELFDDVCAFMVNEGHISTSLIQRHFQIGYNRAARIIDQLEQLGYVSSANGSK PRDVYVTEADLNKE 152. MPKRNDIKTILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYRVILVNSNPATIMTDKEI ADKVYIEPLTHDFIARIIRKEQPDALLPTLGGQTGLNMAIQLHESGVLQDNNVQLLGTEL TSIQQAEDREMFRTLMNDLNVPVPESDIVNTVEQAFKFKEQVGYPLIVRPAFTMGGTGGG ICHNDEELHEIVSNGLHYSPATQCLLEKSIAGFKEIEYEVMRDKNDNAIVVCNMENIDPV GIHTGDSIVVAPSQTLSDVEYQMLRDVSLKVIRALGIEGGCNVQLALDPHSFDYYIIEVN PRVSRSSALASKATGYPIAKLAAKIAVGLTLDEMLNPITGTSYAAFEPTLDYVISKIPRF PFDKFEKGERELGTQMKATGEVMAIGRTYEESLLKAIRSLEYGVHHLGLPNGESFDLDYI KERISHQDDERLFFIGEAIRRGTTLEEIHNMTQIDYFFLHKFQNIIDIEHQLKEHQGDLE YLKYAKDYGFSDKTIAHRFNMTEEEVYQLRMENDIKPVYKMVDTCAAEFESSTPYYYGTY ETENESIVTDKEKILVLGSGPIRIGQGVEFDYATVHAVWAIQKAGYEAIIVNNNPETVST DFSISDKLYFEPLTEEDVMNIINLEKPKGVVVQFGGQTAINLADKLAKHGVKILGTSLEN LNRAEDRKEFEALLRKINVPQPQGKTATSPEEALANAAEIGYPVVVRPSYVLGGRAMEIV DNDKELENYMTQAVKASPEHPVLVDRYLTGKEIEVDAICDGETVIIPGIMEHIERAGVHS GDSIAVYPPQTLTEDELATLEDYTIKLAKGLNIIGLINIQFVIAHDGVYVLEVNPRSSRT VPFLSKITDIPMAQLAMRAIIGEKLTDMGYQEGVQPYAEGVFVKAPVFSFNK LKNVDITL GPEMKSTGEVMGKDTTLEKALFKGLTGSGVEVKDHGTVLMTVSDKDKEEVVKLAQRLNEV GYKILATSGTANKLAEYDIPAEVVGKIGGENDLLTRIQNGDVQIVINTMTKGKEVERDGF QIRRTTVENGIPCLTSLDTANALTNVIESMTFTMRQM 153. MINRDNKKAITKKGMISNRLNKFSIRKYTVGTASILVGTTLIFGLGNQEAKAAENTSTEN AKQDDATTSDNKEVVSETENNSTTENNSTNPIKKETNTDSQPEAKKESTSSSTQKQQNNV TATTETKPQNIEKENVKPSTDKTATEDTSVILEEKKAPNNTNNDVTTKPSTSEPSTSEIQ TKPTTPQESTNIENSQPQPTPSKVDNQVTDATNPKEPVNVSKEELKKNPEKLKELVRNDS NTDHSTKPVATAPTSVAPKRVNAKMRFAVAQPAAVASNNVNDLIKVTKQTIKVGDGKDNV AAAHDGKDIEYDTEFTIDNKVKKGDTMTINYDKNVIPSDLTDKNDPIDITDPSGEVIAKG TFDKATKQITYTFTDYVDKYEDIKSRLTLYSYIDKKTVPNETSLNLTFATAGKETSQNVT VDYQDPMVHGDSNIQSIFTKLDEDKQTIEQQIYVNPLKKSATNTKVDIAGSQVDDYGNIK LGNGSTIIDQNTEIKVYKVNSDQQLPQSNRIYDFSQYEDVTSQFDNKKSFSNNVATLDFG DINSAYIIKVVSKYTPTSDGELDIAQGTSMRTTDKYGYYNYAGYSNFIVTSNDTGGGDGT VKPEEKLYKIGDYVWEDVDKDGVQGTDSKEKPMANVLVTLTYPDGTTKSVRTDANGHYEF GGLKDGETYTVKFETPTGYLPTKVNGTTDGEKDSNGSSVTVKINGKDDMSLDTGFYKEPK YNLGDYVWEDTNKDGIQDANEPGIKDVKVTLKDSTGKVIGTTTTDASGKYKFTDLDNGNY TVEFETPAGYTPTVKNTTADDKDSNGLTTTGVI KDADNMTLDRGFYKTPKYSLGDYVWYD SNKDGKQDSTEKGIKDVTVTLQNEKGEVIGTTKTDENGKYRFDNLDSGKYKVIFEKPAGL TQTVTNTTEDDKDADGGEVDVTITDHDDFTLDNGYFEEDTSDSDSDSDSDSDSDSDSDSD SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD SDSDSDSDSDSDSDSDSDSDSDSDSDAGKHTPVKPMSTTKDHHNKAKALPETGSENNGSN NATLFGGLFAALGSLLLFGRRKKQNK 154. MTHLLETFEMSIDHQEDGLVVISMPVTDKVKQPFGYLHGGASIALGETACSLGSANLIDT TKFIPLGLEMNANHIHSAKDGRVTATAEIIHRGKSTHVWDIKIKNDKEQLITVMRGTVAI KPLK 155. MEHTTMKITTIAKTSLALGLLTTGVITTTTQAANATTPSSTKVEAPQSTPPSTKIEAPQS KPNATTPPSTKVEAPQQTANATTPPSTKVTTPPSTNTPQPMQSTKSDTPQSPTTKQVPTE INPKFKDLRAYYTKPSLEFKNEIGIILKKWTTIRFMNVVPDYFIYKIALVGKDDKKYGEG VHRNVDVFVVLEENNYNLEKYSVGGITKSNSKKVDHKAGVRITKEDNKGTISHDVSEFKI TKEQISLKELDFKLRKQLIEKNNLYGNVGSGKIVIKMKNGGKYTFELHKKLQENRMADVI NSEQIKNIEVNLK 156. MKKQIISLGALAVASSLFTWDNKADAIVTKDYSGKSQVNAGSKNGTLIDSRYLNSALYYL EDYIIYAIGLTNKYEYGDNIYKEAKDRLLEKVLREDQYLLERKKSQYEDYKQWYANYKKE NPRTDLKMANFHKYNLEELSMKEYNELQDALKRALDDFHREVKDIKDKNSDLKTFNA AEE DKATKEVYDLVSEIDTLVVSYYGDKDYGEHAKELRAKLDLILGDTDNPHKITNERIKKEM IDDLNSIIDDFFMETKQNRPKSITKYNPTTHNYKTNSDNKPNFDKLVEETKKAVKEADDS WKKKTVKKYGETETKSPVVKEEKKVEEPQAPKVDNQQEVKTTAGKAEETTQPVAQPLVKI PQGTITGEIVKGPEYPTMENKTVQGEIVQGPDFLTMEQSGPSLSNNYTNPPLTNPILEGL EGSSSKLEIKPQGTESTLKGTQGESSDIEVKPQATETTEASQYGPRPQFNKTPKYVKYRD AGTGIREYNDGTFGYEARPRFNKPSETNAYNVTTHANGQVSYGARPTYKKPSETNAYNVT THANGQVSYGARPTQNKPSKTNAYNVTTHGNGQVSYGARPTQNKPSKTNAYNVTTHANGQ VSYGARPTYKKPSKTNAYNVTTHADGTATYGPRVTK 157. MKKLATVGSLIVTSTLVFSSMPFQNAHADTTSMNVSNKQSQNVQNHRPYGGVVPQGMTQA QYTELEKALPQLSAGSNMQDYNMKLYDATQNIADKYNVIITTNVGVFKPHAVRDMNGHAL PLTKDGNFYQTNVDANGVNHGGSEMVQNKTGHMSQQGHMNQNTHMNQQPHMQQGHMQSSN HQMMSPKANMHSSNHQMNQSNKKVLPAAGESMTSSILTASIAALLLVSGLFLAFRRRSTNK 158. VLRSDFYMSYSIVRVSKVKSGTNTTGIQKHVQRENNNYENEDIDHSKTYLNYDLVNANKQ NFNNLIDEKIEQNYTGKRKIRTDAIKHIDGLITSDNDFFDNQTPEDTKQFFEYAKEFLEQ EYGKDNLLYATVHMDEKTPHMHYGVVPITDDGRLSAKEVVGNKKALTAFQDRFNEHVKQR GYDLERGQSRQVTNAKHEQISQYKQKTEYHKQEYERESQKTDHIKQKNDKLMQEYQKSLN TLKKPINVPYEQETEKVGGLFSKEIQETGNVVI SQKDFNEFQKQIKAAQDISEDYEYIKS GRALDDKDKEIREKDDLLNKAVERIENADDNFNQLYENAKPLKENIEIALKLLKILLKEL ERVLGRNTFAERVNKLTEDEPMA 159. atgatgaaaaagttaaaagcgagtgaaattagacaaaaatatctagatttctttgttgaa aaaggacatatggttgaaccttctgcaccattagtgccaattgatgatgatacattatta tggattaattcaggtgtagcaacattaaagaaatattttgatggacgtgaaacacctaaa aagccaagaattgtaaactctcaaaaagctattcgtacaaatgatattgaaaatgttggt ttcacagcgcgtcaccatacattctttgaaatgttaggtaacttctcaattggtgattat tttaaacaagaagcgattgaatttgcttgggaatttttaacgagtgataaatggatgggt atggagccagataaattgtacgttacgattcatccggaagatatggaagcatacaacatt tggcataaagatattgggcttgaagaaagtcgtattattcgcattgaaggtaacttctgg gatattggtgaagggccttcaggaccgaacactgagattttctatgatcgcggagaagca tatggacaagacgatccggcagaagaaatgtatccaggtggagaaaatgaacgctatctt gaagtatggaacttagtatttagtgaattcaatcataataaagatcatagttacacacca ttacctaataaaaatattgatactggcatggggcttgagcgtatggcctcagtttctcaa aatgtacgtactaactatgaaacagatttatttatgcctataatgaatgaaatcgaaaaa gtatcaggtaaacaatatttagtaaacaacgaacaagatgtggcatttaaagtaattgct gaccacattcgtacgattgcatttgcaa tttctgatggtgcattacctgccaatgaaggt agagggtatgtattacgtcgattgttacgtcgtgccgttcgttttagtcaaacgttagga atcaatgagccatttatgtacaaacttgttgatattgttgcagacattatggaaccatat tatccaaatgttaaggaaaaagcagatttcattaagcgtgttataaagtctgaagaagaa cgattccatgaaacattagaagatggtttagcgattttaaatgaattaattaaaaaagct aaagcgacaacaaatgaaattaatgggaaagatgcatttaaattgtatgatacgtatggg ttcccaattgaattaactgaagaaatagcagtgcaagcaggattgaaagttgatatgaca acattcgagtcagaaatgcaacaacaacgtgatcgtgcacgtcaagcacgtcaaaattct caatcaatgcaagttcaaagtgaagtattgaaaaatattacatctgcaagtacttttgtt ggttatgatactgcgacagctcaaacaacactaacacacttgatatacaatggtgaagaa gtttcacaagttgaagcgggtgaaacagtatacttcatgttaacggaaacaccattttat gcaatcagtggtggacaagttgcggatacaggtattgtttataatgacaattttgaaatt gctgttagtgaagtaaccaaagcaccaaatggtcaaaacttgcataaaggagtagtacaa tttggccaagtaaatgttggcgctacagtgtctgctgaagtgaaccaaaatgatcgacgt gacattcaaaagaaccatagtgcaacacatttattacatgcagcgttgaaatcagtactg ggtgatcatgttaaccaagctggttcactagtagaagcagatcgtttacgttttgatttc tctcattttggtccaatgactaatgatgaaattgatcaagttgaacgcttag taaatgaa gaaatttggaaaggtattgacgttaacattcaagaaatggatattgcttcagctaaagaa atgggcgcaatggcattattcggtgaaaaatatggtgatgttgtgcgtgtagtaaatatg gcaccattttcaattgaattatgtggtggtattcatgtccgcaatacttctgaaattggc ttattcaaaatagtaagtgagtcaggtacaggagctggtgtgcgtcgtattgaagcatta acaggtaaagcagctttcttatatttagaagatattcaagagaaatttaatacgatgaaa tcacagctgaaagtgaaatctgatgatcaagtagtcgataagttaacacaattacaagat gaagaaaaagcattattaaaacaattagagcaacgtgacaaagaaatcacatcacttaaa atgggtaatattgaagatcaagttgaagaaatcaatggctataaagtattggttactgaa gtggatgtaccaaatgcgaaagcaattcgctcgacaatggacgattttaaatctaaacta caagatacaattatcattcttgcaagtaatgttgatgataaagtatcgatggttgcaact gtccctaaatctttaacaaataacgttaaagccggtgatcttatcaaacaaatggcacca atcgttggtggtaaaggtggcggtcgtccagatatggctcaaggtggcggtacacaacct gaaaatatctcaaaatcattaagctttattaaagattacattaaaaatcta 160. MMKKLKASEIRQKYLDFFVEKGHMVEPSAPLVPIDDDTLLWINSGVATLKKYFDGRETPK KPRIVNSQKAIRTNDIENVGFTARHHTFFEMLGNFSIGDYFKQEAIEFAWEFLTSDKWMG MEPDKLYVTIHPEDMEAYNIWHKDIGLEESRIIRIEGNFWDIGEGPSGPNTEIFYDRGEA YGQDDPAEEMYPGGENERY LEVWNLVFSEFNHNKDHSYTPLPNKNIDTGMGLERMASVSQ NVRTNYETDLFMPIMNEIEKVSGKQYLVNNEQDVAFKVIADHIRTIAFAISDGALPANEG RGYVLRRLLRRAVRFSQTLGINEPFMYKLVDIVADIMEPYYPNVKEKADFIKRVIKSEEE RFHETLEDGLAILNELIKKAKATTNEINGKDAFKLYDTYGFPIELTEEIAVQAGLKVDMT TFESEMQQQRDRARQARQNSQSMQVQSEVLKNITSASTFVGYDTATAQTTLTHLIYNGEE VSQVEAGETVYFMLTETPFYAISGGQVADTGIVYNDNFEIAVSEVTKAPNGQNLHKGVVQ FGQVNVGATVSAEVNQNDRRDIQKNHSATHLLHAALKSVLGDHVNQAGSLVEADRLRFDF SHFGPMTNDEIDQVERLVNEEIWKGIDVNIQEMDIASAKEMGAMALFGEKYGDVVRVVNM APFSIELCGGIHVRNTSEIGLFKIVSESGTGAGVRRIEALTGKAAFLYLEDIQEKFNTMK SQLKVKSDDQVVDKLTQLQDEEKALLKQLEQRDKEITSLKMGNIEDQVEEINGYKVLVTE VDVPNAKAIRSTMDDFKSKLQDTIIILASNVDDKVSMVATVPKSLTNNVKAGDLIKQMAP IVGGKGGGRPDMAQGGGTQPENISKSLSFIKDYIKNL 161. atgaatagtgagtttatatatggacgggtaacaaatttaggaggtaagattttgagttta ataaagaaaaagaataaagatattcgcattataccattaggcggtgttggcgaaattgct aaaaatatgtatatcgttgaagtagacgatgaaatgtttatgttagatgctggacttatg tttccagaagacgaaatgctaggtattgatattgttataccagacatttcatacgtactt gaaaataaagataaattgaagggtatattccttacacacggacatgagcacgcgattggt gcagtgagttatgttttagaacaattagatgcaccagtatatggatctaaattgacaata gcgttaattaaagaaaatatgaaagcccgtaatattgataaaaaagttcgctactataca gttaataatgattcaattatgagattcaaaaacgtgaatattagtttctttaatacgaca cacagtattcctgatagtttaggtgtttgtattcacacttcatatggtgccattgtgtat acaggtgaatttaagtttgaccaaagtttacatggacattatgcaccagatattaaacgt atggcagagattggtgaagaaggcgtatttgtcttaatcagtgattctactgaggcagag aaacctggatataatactccggaaaatgtgattgaacatcatatgtatgatgcttttgca aaagtgcgaggtcgcttgatagtttcatgttatgcttcgaactttatacgtattcagcaa gttttaaatattgctagcaagctaaatcgtaaagtgtcatttttaggaagatcacttgaa agttcatttaatattgctcgtaaaatggggtatttcgacattcctaaagatttgctaatt cctataacagaagttgataattatcctaaaaatgaagtgataattatagctactggtatg caaggagaacctgtagaagccttaagtcaaatggcgcaacataagcataaaattatgaat atcgaagaaggcgattctgtatttttagcaattacggcttctgctaatatggaagttatc attgcgaatacattaaatgagcttgtacgtgctggcgcacatattattccaaataacaaa aagattcatgcttcaagtcatggttgcatggaagaattaaaaatgatgattaatattatg aaacctgaatactttattcctgtacaaggtgaatttaaaatgcagatagcacatgcgaag ctagcagctgaagcaggtgttgca ccagaaaagattttccttgtggaaaaaggagatgtc attaattacaacggtaaagatatgatattaaatgaaaaggtaaattcaggaaatatttta atagatggcattggtattggggatgtaggaaatatcgtgttgagagaccgtcatctttta gcagaagatggtatctttattgctgttgtaacgttagatcctaaaaatagacgtatagct gcgggacctgaaattcaatctcgtgggtttgtatatgtacgtgaaagtgaagacttatta cgtgaagcagaagagaaagtacgtgaaatagtagaggctggtttacaagaaaaacgcata gaatggtctgaaattaaacaaaatatgcgtgatcaaattagtaaactattattcgaaagt acaaaacgtcgtcctatgattattccagtaatttctgaaatt 162. MNSEFIYGRVTNLGGKILSLIKKKNKDIRIIPLGGVGEIAKNMYIVEVDDEMFMLDAGLM FPEDEMLGIDIVIPDISYVLENKDKLKGIFLTHGHEHAIGAVSYVLEQLDAPVYGSKLTI ALIKENMKARNIDKKVRYYTVNNDSIMRFKNVNISFFNTTHSIPDSLGVCIHTSYGAIVY TGEFKFDQSLHGHYAPDIKRMAEIGEEGVFVLISDSTEAEKPGYNTPENVIEHHMYDAFA KVRGRLIVSCYASNFIRIQQVLNIASKLNRKVSFLGRSLESSFNIARKMGYFDIPKDLLI PITEVDNYPKNEVIIIATGMQGEPVEALSQMAQHKHKIMNIEEGDSVFLAITASANMEVI IANTLNELVRAGAHIIPNNKKIHASSHGCMEELKMMINIMKPEYFIPVQGEFKMQIAHAK LAAEAGVAPEKIFLVEKGDVINYNGKDMILNEKVNSGNILIDGIGIGDVGNIVLRDRHLL AEDGIFIAVVTLDPKNRRIAAGPEIQSRGFVYVRESEDLLREAEEKVREIVEAGLQEKRI EWSEIKQNMRDQISKLLFESTKRRPMIIPVISEI 163. atggaaataacaatgcctaagttaggtgagagtgttcatgaaggcaccattgaacaatgg ttagtttctgttggtgatcatattgatgaatatgaaccattatgtgaagttattacagat aaagtgacagctgaagtcccttccacgatatcaggaacaattacagaaattttagttgaa gcggggcagacagtagctattgatacaattatctgtaaaattgaaactgctgatgaaaag acaaatgaaacaactgaagagatacaagcaaaagtggatgagcatactcagaaatctact aaaaaagctagtgcaacagtggaacagacatctactgctaaacaaaatcaaccacgtaat aatggtcgcttttcacctgttgtatttaaactcgcttcagagcatgacattgatttatca caagttgtaggtagtggatttgaaggtcgtgtaactaagaaggatataatgtcagttatt gaaaatggtggtaccacagctcaatctgacaaacaagttcaaacaaaatcaacatcagta gatacatcaagtaaccaatcatctgaagacaatagtgaaaacagcacaataccagtaaat ggtgtgcgtaaagcaattgcgcaaaatatggttaatagtgtaacagagattccacatgca tggatgatgattgaagtagatgctacaaatcttgtgaaaacgagaaatcattataaaaac agctttaaaaataaagaaggatataatctaacgttctttgctttctttgtaaaagctgta gcagatgctttaaaagcatatcctttattaaatagtagctggcaaggaaatgaaattgtc ttacataaagacattaatatttcaattgctgttgctgatgaaaataaattatacgtacct gtgattaagcatgcagacgaaaagtcaatcaaaggtatagctaga gaaattaatacttta gcaacgaaagcgcgtaataagcaattgacagctgaagatatgcagggcggtacatttacg gtaaataatactggtacatttggttcagtatcatcaatgggtattataaatcatccacaa gcagcgattttacaagtagaatcaatcgttaaaaagccagtagtaattaatgatatgatt gcaattcgtaacatggttaatttatgtatttcaattgatcatcgtattttagatggttta caaacaggtaaatttatgaatcatattaaacagcgtatcgaacagtatactttagaaaat acaaatatatat 164. MEITMPKLGESVHEGTIEQWLVSVGDHIDEYEPLCEVITDKVTAEVPSTISGTITEILVE AGQTVAIDTIICKIETADEKTNETTEEIQAKVDEHTQKSTKKASATVEQTSTAKQNQPRN NGRFSPVVFKLASEHDIDLSQVVGSGFEGRVTKKDIMSVIENGGTTAQSDKQVQTKSTSV DTSSNQSSEDNSENSTIPVNGVRKAIAQNMVNSVTEIPHAWMMIEVDATNLVKTRNHYKN SFKNKEGYNLTFFAFFVKAVADALKAYPLLNSSWQGNEIVLHKDINISIAVADENKLYVP VIKHADEKSIKGIAREINTLATKARNKQLTAEDMQGGTFTVNNTGTFGSVSSMGIINHPQ AAILQVESIVKKPVVINDMIAIRNMVNLCISIDHRILDGLQTGKFMNHIKQRIEQYTLEN TNIY 165. 166. 167. atggaggacaacatgatttatgcaggtattttagcaggaggtattggttcgagaatgggg aacgtgccattaccaaaacaatttttagatattgataataaaccgattttaatccataca attgagaagttcattttagtgagtgaatttaatgagattattatcgcaacgccagcacag tggatttcccatacacaggatattttaaaaa aatataacattacagatcaacgtgtcaaa gtagttgcaggtggtacggatcgaaatgaaacaattatgaacattatcgaccatattcgc aatgtaaatggaattaataatgatgatgtgattgtaactcatgatgccgtaagaccattt ttaactcaacgtattattaaagagaacattgaagtagcagcaaaatatggtgcagtagat acagtcattgaagcaattgatacgattgtaatgtctaaagataaacagaacatacacagt atccctgtaaggaatgaaatgtatcaaggccaaacaccacaatcatttaatattaaatta ttacaagatagttatcgcgccttaagtagtgaacaaaaagaaatcttatcagatgcatgt aaaatcattgtcgaatctggacatgcagttaaattggtacgtggagaactatacaacatt aaagtgacaacaccgtatgatttaaaagtagcaaatgccattattcaaggtgatattgcc gatgat 168. MEDNMIYAGILAGGIGSRMGNVPLPKQFLDIDNKPILIHTIEKFILVSEFNEIIIATPAQ WISHTQDILKKYNITDQRVKVVAGGTDRNETIMNIIDHIRNVNGINNDDVIVTHDAVRPF LTQRIIKENIEVAAKYGAVDTVIEAIDTIVMSKDKQNIHSIPVRNEMYQGQTPQSFNIKL LQDSYRALSSEQKEILSDACKIIVESGHAVKLVRGELYNIKVTTPYDLKVANAIIQGDIA DD 169. atgataatatattggtgtatgacagttaatggagggaacgaaatgaaagctttattactt aaaacaagtgtatggctcgttttgctttttagtgtaatgggattatggcaagtctcgaac gcggctgagcagcatacaccaatgaaagcacatgcagtaacaacgatagacaaagcaaca acagataagcaacaagtaccgccaacaaaggaagc ggctcatcattctggcaaagaagcg gcaaccaacgtatcagcatcagcgcagggaacagctgatgatacaaacagcaaagtaaca tccaacgcaccatctaacaaaccatctacagtagtttcaacaaaagtaaacgaaacacgc gacgtagatacacaacaagcctcaacacaaaaaccaactcacacagcaacgttcaaatta tcaaatgctaaaacagcatcactttcaccacgaatgtttgctgctaatgcaccacaaaca acaacacataaaatattacatacaaatgatatccatggccgactagccgaagaaaaaggg cgtgtcatcggtatggctaaattaaaaacagtaaaagaacaagaaaagcctgatttaatg ttagacgcaggagacgccttccaaggtttaccactttcaaaccagtctaaaggtgaagaa atggctaaagcaatgaatgcagtaggttatgatgctatggcagtcggtaaccatgaattt gactttggatacgatcagttgaaaaagttagagggtatgttagacttcccgatgctaagt actaacgtttataaagatggaaaacgcgcgtttaagccttcaacgattgtaacaaaaaat ggtattcgttatggaattattggtgtaacgacaccagaaacaaagacgaaaacaagacct gaaggcattaaaggcgttgaatttagagatccattacaaagtgtgacagcggaaatgatg cgtatttataaagacgtagatacatttgttgttatatcacatttaggaattgatccttca acacaagaaacatggcgtggtgattacttagtgaaacaattaagtcaaaatccacaattg aagaaacgtattacagttattgatggtcattcacatacagtacttcaaaatggtcaaatt tataacaatgatgcattggcacaaacaggtacagcacttgcgaatatcggtaagattac a tttaattatcgcaatggagaggtatcgaatattaaaccgtcattgattaatgttaaagac gttgaaaatgtaacaccgaacaaagcattagctgaacaaattaatcaagctgatcaaaca tttagagcacaaactgcagaggtaattattccaaacaataccattgatttcaaaggagaa agagatgacgttagaacgcgtgaaacaaatttaggaaacgcgattgcagatgctatggaa gcgtatggcgttaagaatttctctaaaaagactgactttgccgtgacaaatggtggaggt attcgtgcctctatcgcaaaaggtaaggtgacacgctatgatttaatctcagtattacca tttggaaatacgattgcgcaaattgatgtaaaaggttcagacgtctggacggctttcgaa catagtttaggcgcaccaacaacacaaaaggacggtaagacagtgttaacagcgaatggc ggtttactacatatctctgattcaatccgtgtttactatgatataaataaaccgtctggc aaacgaattaatgctattcaaattttaaataaagagacaggtaagtttgaaaatattgat ttaaaacgtgtatatcacgtaacgatgaatgacttcacagcatcaggtggcgacggatat agtatgttcggtggtcctagagaagaaggtatttcattagatcaagtactagcaagttat ttaaaaacagctaacttagctaagtatgatacgacagaaccacaacgtatgttattaggt aaaccagcagtaagtgaacaaccagctaaaggacaacaaggtagcaaaggtagtaagtct ggtaaagatacacaaccaattggtgacgacaaagtgatggatccagcgaaaaaaccagct ccaggtaaagttgtattgttgctagcgcatagaggaactgttagtagcggtacagaaggt tctggtcgcacaatagaaggag ctactgtatcaagcaagagtgggaaacaattggctaga atgtcagtgcctaaaggtagcgcgcatgagaaacagttaccaaaaactggaactaatcaa agttcaagcccagaagcgatgtttgtattattagcaggtataggtttaatcgcgactgta cgacgtagaaaagctagc 170. MIIYWCMTVNGGNEMKALLLKTSVWLVLLFSVMGLWQVSNAAEQHTPMKAHAVTTIDKAT TDKQQVPPTKEAAHHSGKEAATNVSASAQGTADDTNSKVTSNAPSNKPSTVVSTKVNETR DVDTQQASTQKPTHTATFKLSNAKTASLSPRMFAANAPQTTTHKILHTNDIHGRLAEEKG RVIGMAKLKTVKEQEKPDLMLDAGDAFQGLPLSNQSKGEEMAKAMNAVGYDAMAVGNHEF DFGYDQLKKLEGMLDFPMLSTNVYKDGKRAFKPSTIVTKNGIRYGIIGVTTPETKTKTRP EGIKGVEFRDPLQSVTAEMMRIYKDVDTFVVISHLGIDPSTQETWRGDYLVKQLSQNPQL KKRITVIDGHSHTVLQNGQIYNNDALAQTGTALANIGKITFNYRNGEVSNIKPSLINVKD VENVTPNKALAEQINQADQTFRAQTAEVIIPNNTIDFKGERDDVRTRETNLGNAIADAME AYGVKNFSKKTDFAVTNGGGIRASIAKGKVTRYDLISVLPFGNTIAQIDVKGSDVWTAFE HSLGAPTTQKDGKTVLTANGGLLHISDSIRVYYDINKPSGKRINAIQILNKETGKFENID LKRVYHVTMNDFTASGGDGYSMFGGPREEGISLDQVLASYLKTANLAKYDTTEPQRMLLG KPAVSEQPAKGQQGSKGSKSGKDTQPIGDDKVMDPAKKPAPGKVVLLLAHRGTVSSGTEG SGRTIEGATVSSKSGKQLARMSVPKGSAHEKQLPKTGTNQSSSPEAMFVLLAGIGLIATV RRRKAS 171. atgcaagagt accaaaaatcgttaaatacgcttaaaaagcctataaatgttccgtatgag caagaaactgaaaaagtaggtggtttatttagcaaagaaatacaagaaactggaaatgtt gtaataagccaaaaagatttcaatgaatttcagaaacagataaaagctgctcaagatatt tcggaagattacgagtatataaagtctggtagagccttagatgataaagataaggaaata cgagagaaagatgatttattaaataaagcagttgagcgtattgaaaacgcagacgataat tttaaccaactttacgaaaatgcaaagccacttaaagagaatatagaaatagcgttaaag cttttaaaaatcttactaaaagagttagaacgagttttaggaagaaatacctttgcggaa agagttaataagttaacagaagatgaaccaaaactaaatggtttagcaggaaacttagat aaaaaaatgaatccagaattatattcagaacaggaacagcaacaagaacaacaaaagaat caaaaacgagatagaggtatgcactta 172. MQEYQKSLNTLKKPINVPYEQETEKVGGLFSKEIQETGNVVISQKDFNEFQKQIKAAQDI SEDYEYIKSGRALDDKDKEIREKDDLLNKAVERIENADDNFNQLYENAKPLKENIEIALK LLKILLKELERVLGRNTFAERVNKLTEDEPKLNGLAGNLDKKMNPELYSEQEQQQEQQKN QKRDRGMHL 173. atgaagatgataaacaaattaatcgttccggtaacagctagtgctttattattaggcgct tgtggcgctagtgccacagactctaaagaaaatacattaatttcttctaaagctggagac gtaacagttgcagatacaatgaaaaaaatcggtaaagatcaaattgcaaatgcatcattt actgaaatgttaaataaaattttagctgataaatataaaaataaagt taatgataagaag attgacgaacaaattgaaaaaatgcaaaagcaatacggcggtaaagataaatttgaaaag gcccttcaacagcaaggtttaacagccgataaatataaagaaaatttacgtactgctgct tatcataaagaattactatcagataaaattaaaatctctgattctgaaattaaagaagac agcaagaaagcttcacacattttaattaaagttaaatctaagaaaagcgacaaagaaggc ttagatgataaagaagcgaaacaaaaagctgaagaaattcaaaaagaagtttcaaaagat ccaagtaaatttggtgaaatcgctaaaaaagaatcaatggatactggttcagctaaaaaa gatggcgaattaggttatgttcttaaaggacaaactgataaagattttgaaaaagcacta tttaagcttaaagatggtgaagtatcagaggttgttaaatcaagctttggatatcatatt attaaagctgataaaccaacagactttaacagtgaaaaacaaagcctgaaagaaaaatta gtcgatcagaaagtacaaaaaaatccaaaattattgactgatgcatacaaagatctatta aaagaatacgatgttgactttaaagatcgtgatattaaatcagttgtcgaagataaaatc ttaaaccctgaaaaacttaaacaaggtggcgcacaaggcggacaatccggcatgagccaa 174. MKMINKLIVPVTASALLLGACGASATDSKENTLISSKAGDVTVADTMKKIGKDQIANASF TEMLNKILADKYKNKVNDKKIDEQIEKMQKQYGGKDKFEKALQQQGLTADKYKENLRTAA YHKELLSDKIKISDSEIKEDSKKASHILIKVKSKKSDKEGLDDKEAKQKAEEIQKEVSKD PSKFGEIAKKESMDTGSAKKDGELGYVLKGQTDKDFEKALFKLKDGEVSEVVKSSFGYHI IKADK PTDFNSEKQSLKEKLVDQKVQKNPKLLTDAYKDLLKEYDVDFKDRDIKSVVEDKI LNPEKLKQGGAQGGQSGMSQ 175. atgcttttagtattagctggttgctctaattctaacgataataatgaaagtaaaaaagat gacgcagacaatggtaagaaacaagagattcaagttgcagcggcagcaagtttaacagat gtaaccaagaaattagcttcagaatttaaaaaagagcataaaaatgctgatattaaattt aactatggtggatcaggggcattaagaaaacaaattgaatcaggcgcacctgttgacgta tttatgtctgcaaatactaaagatgtagatgcattaaaagacaagaataaagcgcatgat acatataaatatgcgaaaaatagtctagtattaattggtgataaagattcaaattacact tcagtaaaagacttaaaagacaatgataaattagcattaggtgaagtgaaaactgtacca gcaggaaaatatgcgaaacagtatttagataacaataacttatttaaagaagtcgaaagt aaaatcgtttatgctaaagatgtaaaacaagtattaaattatgttgaaaagggtaatgcg aaacaaggttttgtgtataaaactgacttatataaacaaaataaaaaaattgatactgta aaagtaattaaagaagtagaacttaagaagccaatcacatacgaagctggtgctacatca gatagtaaattagcaaaagagtggatggaattcttaaaatcagataaagctaaagaaata ctaaaagaataccactttgcagca 176. MLLVLAGCSNSNDNNESKKDDADNGKKQEIQVAAAASLTDVTKKLASEFKKEHKNADIKF NYGGSGALRKQIESGAPVDVFMSANTKDVDALKDKNKAHDTYKYAKNSLVLIGDKDSNYT SVKDLKDNDKLALGEVKTVPAGKYAKQYLDNNNL FKEVESKIVYAKDVKQVLNYVEKGNA KQGFVYKTDLYKQNKKIDTVKVIKEVELKKPITYEAGATSDSKLAKEWMEFLKSDKAKEI LKEYHFAA 177. ttggcatacacatacactttaaaagatattattgaaattacaggtgtaactaaaagaact ttacattattacgatgaaataggattattagttccagataaaaatgataaaaattatcgc gtttataaacagcaagacttagaaaaattacaaaagattttaatactcaagtcttttgat tttgatatcgctaaaataaaacaatacatttcgtatgataatgaacaattgcgaaagtta ttatcagagcaaataagcaagttagataaaaagatttctgacttacaattaattagacgc tctgtatgtgaatttattaaaggactctctctaatagataccagcattttaaacaagaca ctacagtcacaatatgataaagaagcatctataaaatatggtcatacgaaagcatatcaa tcatttattagacgtaaagacagcttacaatcgcaggatatcagacataaattgacaact atcttcaataaatttaatcatatgtctttgagtcattatccaatccaagattgtagtgat ctcgtatttgagtggaaggcatttatgaacactatcgctgattttgatgatgaaacatta tgctgtattgctaaaacatatgaagatgatacgcgtttcaaagattactttaattcatat gataatcaaaatttagcatcatacatttcagaagctgttaattattttttgagcaatgtg aataagagcgacaatttt 178. MAYTYTLKDIIEITGVTKRTLHYYDEIGLLVPDKNDKNYRVYKQQDLEKLQKILILKSFD FDIAKIKQYISYDNEQLRKLLSEQISKLDKKISDLQLIRRSVCEFIKGLSLIDTSILNKT LQSQYDKEASIKYGHTKAYQ SFIRRKDSLQSQDIRHKLTTIFNKFNHMSLSHYPIQDCSD LVFEWKAFMNTIADFDDETLCCIAKTYEDDTRFKDYFNSYDNQNLASYISEAVNYFLSNV NKSDNF 179. atggcaaaaataaaagcaaatgaagcattagttaaagcattacaagcatgggatatagat cacttgtatggtattccaggagactcaatcgacgcagtagtcgatagtttacgtacagtg agagatcaatttaaattttatcatgtacgtcatgaagaagtagcaagcttagcggctgct ggttacacaaaattaactggtaaaatcggtgtggcattaagtatcggtggccctggttta attcatttattaaatggtatgtatgatgccaaaatggataatgtaccgcaattaatatta tctggacaaacgaatagtacagcacttggaacgaaagcattccaagaaacaaatttacaa aaattatgtgaagatgtagccgtttataatcaccaaattgaaaaaggtgacaatgtgttt gaaatcgttaacgaagcaattcgtacggcatatgaacaaaaaggtgtagctgttgttatt tgtcctaacgacttattaactgaaaaaattaaagatacaacgaataaaccagtagataca tcaagaccaacagtagtatcaccaaaatataaagacatcaaaaaagcggttaaactaatt aataaaagtaaaaagcctgtcatgttaattggtgtaggtgcgaaacatgcgaaagatgag ctacgtgaatttattgaaatggctaaaattcctgtcattcattcattaccagctaaaaca atcttgccggatgatcatccatatagtatcggtaacttaggtaaaatcggtaccaaaaca tcttatcaaacaatgcaggaagcggatttattaattatggttggtacaaactatccatat gtggattacttacctaagaaaaatattaaagc cattcaaattgacacaaatcctaaaaat atcggacatcgtttcaatattaatgtaggaattgttggagatagtaaaattgcgttgcat cagttaactgaaaatattaaacatgttgctgaaagaccattcttaaacaaaacgttagaa cgtaaagcggtttgggataaatggatggaacaagataaaaataataatagtaaaccatta cgtccagaacgattaatggcatcaatcaataaatttattaaagatgatgcagtgatttca gcagatgtaggtacagcaacagtttggtcaactcgatacttaaaccttggtgtaaataac aagttcatcatttcaagttggttaggtacaatgggttgcggtcttccaggtgcaattgca tcaaaaattgcatatccaaatagacaagccatcgcaattgctggtgacggtgcattccaa atggtaatgcaagacttcgctacagcagtacaatatgatttacctttaactgtatttgta cttaataacaaacagttagcatttattaaatatgaacaacaagcagctggtgaattagaa tatgcagttgatttttctgatatggatcatgcaaaatttgctgaggcagcaggtggtaaa ggttatacaattaagagtgctagcgaagtagatgctatagtcgaagaggcattagcacaa gatgtaccaacgattgtagatgtatatgttgatcctaatgctgcgccattaccaggtaaa attgtaaatgaagaagcgcttggttatggtaagtgggcatttagatcaattactgaagat aaacatttagatttagatcaaattccaccaatttcagtggcagcaaaacgtttctta 180. MAKIKANEALVKALQAWDIDHLYGIPGDSIDAVVDSLRTVRDQFKFYHVRHEEVASLAAA GYTKLTGKIGVALSIGGPGLIHLLNGMYDAKMDNVPQLILSGQTNSTALGTKAF QETNLQ KLCEDVAVYNHQIEKGDNVFEIVNEAIRTAYEQKGVAVVICPNDLLTEKIKDTTNKPVDT SRPTVVSPKYKDIKKAVKLINKSKKPVMLIGVGAKHAKDELREFIEMAKIPVIHSLPAKT ILPDDHPYSIGNLGKIGTKTSYQTMQEADLLIMVGTNYPYVDYLPKKNIKAIQIDTNPKN IGHRFNINVGIVGDSKIALHQLTENIKHVAERPFLNKTLERKAVWDKWMEQDKNNNSKPL RPERLMASINKFIKDDAVISADVGTATVWSTRYLNLGVNNKFIISSWLGTMGCGLPGAIA SKIAYPNRQAIAIAGDGAFQMVMQDFATAVQYDLPLTVFVLNNKQLAFIKYEQQAAGELE YAVDFSDMDHAKFAEAAGGKGYTIKSASEVDAIVEEALAQDVPTIVDVYVDPNAAPLPGK IVNEEALGYGKWAFRSITEDKHLDLDQIPPISVAAKRFL 181. gtagtagtttagggcttgcaacgcac 182. caccatcatagaacatacaattgctagc 183. ctgatactggacaacatagaga 184. aagtaacgttatctttcgaatggt 185. atttctggcactcaagtatatcaagac 186. tggcttaggtgttggtgtaggc 187. ataatgcaactacaactcagcc 188. ttgatcgttgatgtattttgattagat 189. ctacaataactacagccgttaca 190. gtgaatgaagttataaccagcag 191. cacgctaaagcatcagtgacaga 192. agcattttgatgtgttgctgttgtgtt 193. gaatccccaagcacctaaac 194. gtaaacgttgatcaagcacact 195. tttgcaataacagcaacatctggtgcag 196. gaaacttctgaagctggaattgtacgg 197. atgagaaaaactaaaattgtatgtacaattggac cagcttcagaatcagaagaaatgatt gagaaattaatcaatgctggtatgaacgttgcacgattaaacttttcacatggtagtcat gaagagcataaaggtagaattgatacaattcgtaaagtagctaaaagattagacaaaatt gtagcaattttattagatacaaaaggtccagaaattcgtacgcataatatgaaagacggt atcattgaacttgaacgtggcaacgaagttattgttagcatgaatgaagttgaaggaaca cctgaaaagttctcagtaacatatgaaaacttaattaacgatgttcaagtaggttcatac attttacttgatgatggcttaattgaattacaagttaaagatattgaccatgctaaaaaa gaagttaaatgtgatattttaaactctggtgagcttaaaaacaaaaaaggtgttaactta cctggcgtaagagtaagtttacctggtattacagaaaaagatgctgaagatatccgtttc ggtattaaagaaaatgttgacttcattgcagcaagtttcgtacgtcgtcctagtgatgtt ttagaaattcgtgaaattttagaagaacaaaaagctaacatttcagtattccctaaaatt gaaaaccaagaaggtattgataatattgcggaaattcttgaagtgtctgatggtttaatg gttgcacgtggtgacatgggtgttgaaattccacctgaaaaagtaccaatggttcaaaaa gatttaatcagacaatgtaacaaattaggtaaaccagttattacagctacacaaatgtta gattctatgcaacgtaacccacgtgctacacgtgcagaagctagtgacgttgccaacgca atctatgatggtacagatgcagtaatgttatctggtgaaactgctgctggtttatatcct gaagaagctgttaaaacaatgagaaatattgctgtatcagctgaagcagcccaagatt ac aaaaagttattgtcagatcgtactaaattagttgaaacttcattagtgaatgctatcggt atttcggttgcacatacagctttaaacttaaatgttaaagcaattgtagctgctactgaa agtggttcaacggcacgtactatctccaaatatcgtccacattcagacattattgcggtg actccaagtgaagaaactgcacgtcaatgttcaattgtttggggagttcaacctgtagtt aaaaaaggacgtaagagtacagatgcattgttaaacaatgcagttgcaacagctgttgaa actggtagagtatctaatggtgatttaatcattattactgctggtgtaccaactggtgaa actggaactactaatatgatgaaaatccacctagttggtgacgaaattgctaatggtcaa ggtattggacgtggatcagttgttggtactacgttagttgctgaaactgttaaagattta gaaggtaaagatttatctgacaaagttatcgttactaactcaatcgatgaaacgtttgta ccttatgtagaaaaagctttaggcttaattacagaagaaaatggtattacatcaccaagt gcaattgttggtttagaaaaaggtattccaacagttgtaggtgtagaaaaagctgttaaa aacataagcaataacatgttagttacgattgatgctgctcaaggtaaaatctttgaagga tatgcaaacgtacta 198. atgcaattcgataatattgacagtgctttaatggctttaaaaaatggagaaccaattatt gtagtagatgatgagaatcgtgaaaatgaaggtgatttagtagcggttactgaatggatg aacgataataccattaattttatggcgaaagaagcaaggggattaatatgcgcaccagtg tctaaagatattgcacaacgtttggatttggtacaaatggttgatgataactccgacatc tttggtacgcaatttacagtgagtattgatcatgtagatacaacaacaggaattagtgct tatgaacgtacattgactgccaaaaagctcattgatcctagtagtgaagctaaagatttt aatcgtcctggtcatttatttccattagtagcacaagataaaggcgtattagctagaaat ggacacacagaagcggctgttgatttagctaaacttactggtgccaagcccgctggtgtc atttgtgagattatgaatgatgacggcacgatggcgaaaggacaagatttacaaaagttt aaagaaaaacatcaattaaagatgattacgattgatgatttaattgaatatcgtaaaaaa ttagaaccagaaattgaatttaaggcaaaagtgaaaatgcctacagatttcggaacattt gatatgtatggttttaaagcgacatacacagatgaagagatagttgtactgacaaaaggt gcaattcgacaacatgaaaatgtacgcttacattctgcgtgccttacaggcgatattttc catagtcaacgttgtgattgtggtgctcaacttgaatcgtctatgaagtatatcaatgaa catggtggcatgattatttatctacctcaagaaggtcgtggcataggattgttaaacaaa ttacgcgcatatgaattaattgagcaaggatatgatacagtaactgcaaatttagcatta ggttttgatgaagatttgcgagattatcatattgctgcacagattttaaaatattttaac atcgaacatatcaatttattaagtaataatccaagtaaatttgagggattaaaacaatat ggcattgatattgcagaaagaattgaagttatcgtaccagaaacggtacataatcatgat tatatggaaacgaaaaaaataaaaatgggtcatttaata 199. atgaaaatgaaaaaattagtcaaatcatcagttgcttcat caattgcactgcttttgcta tcgaatacagttgatgcagctcaacatatcacacctgtaagcgagaaaaaagtagatgac aaaatcactttatacaaaacaacagcaacatctgataatgataaattgaatatttctcaa attttaacgtttaatttcattaaggataaaagttatgacaaagatacgttagtacttaag gcagccggaaacattaattcaggttataaaaagcctaatccaaaagattacaattactca cagttttattggggcggtaagtataatgtttcggttagttcagaatcaaatgatgctgta aatgttgttgactatgcacctaaaaatcaaaatgaagaattccaagttcaacaaacatta ggttattcttatggcggagatattaatatatctaatggcttatcaggtggattaaatgga tcaaaatcattttcagaaacgataaattataaacaagaaagttacagaactacgattgat agaaaaacaaatcataaatcaattggctggggtgttgaggcgcacaaaattatgaataat ggttggggaccatatggtagagatagttatgacccaacatatggtaatgaactgttttta ggcggtagacaaagtagttcaaatgctggtcaaaatttcttgccaacacatcaaatgcct ttattggcgcgtggtaactttaacccagaatttataagcgtactttctcataaacaaaat gatacaaaaaaatctaaaatcaaagtaacttaccaaagagaaatggatagatatactaat caatggaatcgactacactgggttggtaataactacaaaaatcaaaatacagtaacgttt acatctacttatgaagttgactggcaaaaccatactgttaaattaatcggtacggattct aaagaaactaatcctggagta 200. Atgaagaaaaaagcgttactaccattatttttaggta ttatggtctttttggctggttgt Gactattctaaacctgaaaaacgtagtgggtttttctacaatacattcgtagatccaatg Aaaaatgtattggattggttgggaaataacttattaaacgacaattatggtttagctatt Attatccttgtattggtaattcgtattattttattaccattcatgttgtcaaactataaa Aatagtcatatgatgcgtcaaaaaatgaaagttgcaaagccagaagttgaaaaaattcaa Gaaaaagtgaaacgtgcgcgtacacaagaagaaaaaatggctgcaaaccaagaattaatg Caagtatataaaaagtatgacatgaacccgattaagagtatgttgggttgtttaccaatg Ctaatccaattaccaatcatcatgggattatactttgtacttaaagaccaacttgtagat Ggtttgtttaaatatccacacttcttatggttcgatttaggacgtcctgatatttggatt Acaattattgccggtgttttatactttatccaagcatatgtatcaagtaaaacgatgcca Gacgaacaacgtcaaatgggttacatgatgatggtcatttcaccaattatgattatctgg Atttcattaagctcagcatcagcacttggtttgtactggtcagtcagtgcggcgttcctt Gtagttcaaacacactttgcgaacatttattatgaaaaagtcgctaaaaaagaagtacaa Cctttcattgaagcgtatgaaagagagcacaacggcggcagcaataaaaaaggcaaaaac acacaagttgtgtctaaaaagaaaaagaaa 201. atgaatttattcagacaacaaaaatttagtatcagaaaatttaatgtcggtattttttca gctttaattgccactgttacttttatatctactaacccgacaacagcgtctgcagcagag caaaatcagcctgcacaaaatcaac cagcacaaccagctgatgccaatacacagcctaac gcaaatgctggtgctcaagctaatcctacagcacagccagctgcacctgccaaccaagga caaccagcagtacaaccagcaaaccaaggtggacaggctaatccagcaggaggagcagca caaccaaatacacaaccagctggacaaggtaatcaagctgatccgaataacgctgcacaa gcacaacctggaaatcaagcaacaccggcaaaccaagcaggtcaaggaaataaccaagca acacctaataataatgcaacaccggcaaatcaaacacagccagcgaatgctccagcagca gcgcaaccagcagcacctgtagcagcaaacgcacaaactcaagatccaaatgctagcaat actggtgaaggcagtattaatacgacattaacatttgatgatcctgccatatcaacagat gagaatagacaggatccaactgtaactgttacagataaagtaaatggttattcattaatt aacaacggtaagattggtttcgttaactcagaattaagacgaagcgatatgtttgataag aataaccctcaaaactatcaagctaaaggaaacgtggctgcattaggtcgtgtgaatgca aatgattctacagatcatggtaactttaacggtatttcaaaaactgtaaatgtaaaacca gattcagaattaattattaactttactactatgcaaacgaatagtaagcaaggtgcaaca aatttagttattaaagatgctaagaaaaatactgaattagcaactgtaaatgttgctaag actggtactgcacatttatttaaagtaccaactgatgctgatcgtttagatttacaattt attcctgacaatacagcagttgctgatgcttcaagaattacaacaaataaagatggttat aaatactattcattcattgataatgtaggtctattctcaggatcacatt tatatgtcaaa aatagagatttagcaccgaaagcaactaacaataaagaatatactattaatactgaaatc ggtaacaatggtaattttggtgcttcattaaaagcagatcaatttaaatatgaagtaaca ttaccacaaggtgtaacttacgttaataattcattaactacaacattccctaatggtaat gaagacagtacagtattgaaaaatatgactgttaattatgatcaaaatgcaaataaagtt acatttacaagccaaggtgtgacaacggcacgtggtacacacactaaagaagttttattc ccagataaatctttaaaattatcatataaagttaatgttgcgaatatcgatacacctaaa aatattgattttaatgaaaaattaacatatcgtactgcttcagatgttgtaattaataat gcgcaaccagaagttacactaactgcagatccattttcagtagcggttgaaatgaacaaa gatgcgttgcaacaacaagtaaactcacaagttgataatagtcattacacaacagcatca attgcagaatacaataaacttaaacaacaagcagatactattttaaatgaagatgcgaat catgttaaaactgcaaatcgtgcatctcaagcggatattgatggtttagtaactaaatta caagctgcattaattgataatcaagcagcaattgctgaattagatactaaagctcaagaa aaggttacagcagcacaacaaagtaaaaaagttacgcaagatgaagttgcagcacttgta actaaaattaacaatgataaaaataatgcaatcgcagaaattaataaacaaactacagca caaggtgtcacaactgaaaaagataatggtatcgcagtgttagaacaagatgtgattaca ccaacagttaaacctcaagcgaaacaagatattatccaagcagttacaactcgtaaacaa caaattaaaaag tcaaatgcatcattacaagatgaaaaagatgtagcaaatgataaaatt ggtaaaattgaaacaaaggcaattaaagatattgatgcagcaacaacaaatgcacaagta gaagccattaaaacaaaagcaatcaatgatattaatcaaactacacctgctacaacagct aaagcagcagctcttgaagaatttgacgaagttgttcaagcacaaattgatcaagcacct ttaaatcctgatacaacaaatgaagaagtagcggaagctattgaacgtattaatgcagct aaagtttctggtgttaaagcaattgaagcgacaacgactgcacaagatttagaaagagtt aaaaacgaagaaatctcaaaaattgaaaatattactgactctacgcaaacaaaaatggat gcctataatgaagttaaacaagctgcaacagctagaaaagctcaaaatgctacagtttca aatgcaacaaatgaagaagtagcagaagctgatgcagcagtagatgcagctcaaaagcaa ggtttacatgacatccaagttgttaaatcaaaacaggaagttgctgatacaaaatcaaaa gtattagataaaatcaatgcaattcaaacacaagcaaaagttaaacctgcagctgatacg gaagtagaaaacgcatataatacacgtaaacaagaaattcaaaatagcaatgcttcaact acagaagaaaaacaagctgcatatacagaattagatactaaaaagcaagaagcaagaaca aatcttgatgctgcaaatacaaacagtgatgtaacaacagctaaagacaatagtattgct gcaattaatcaagttcaagctgccacaactaagaaatcggatgcaaaagcggaaatcgct caaaaagcaagtgaacgtaaaacagcaattgaagcaatgaatgattcgactactgaagaa caacaagcagcgaaagacaaagtggatcaagcagta gttactgcaaacgctgatatagat aatgctgcagcaaacaatgatgtggataatgcaaaaactacaaatgaagctacaatcgca gccattacacctgatgcaaatgttaaaccagcagcaaaacaagcaattgcagataaagta caagctcaagaaacagcaattgatggaaataacggctcaacaactgaagaaaaagcagct gctaaacaacaagttcaaactgaaaaaacaacagctgatgccgcaatagatgcagcacat acaaatgcggaagttgaagcggctaaaaaagcagcaattgctaaaattgaagcgattcag ccagcaacaacaactaaagataatgcgaaagaagcaattgctacgaaagcgaatgaacgt aaaacagcaatcgctcaaacgcaagacattactgctgaagaaattgcagcggctaatgcg gacgtagataatgctgtgacacaagcaaatagcaacattgaagctgctaatagtcaaaat gatgtagaccaagcgaaaacgacaggtgaaaatagtattgatcaagtaacaccaacagtt aataaaaaagcaactgcacgtaatgaaatcacagcaattttaaataacaaattgcaagag attcaagctacgccagatgcaacagatgaagaaaaacaagcagctgatgctgaagcaaat actgaaaatggtaaagcaaatcaagccatttcagcagcaactactaacgcacaagttgat gaagctaaagcaaatgcagaagcagcgattaatgcggtaacaccaaaagttgtgaagaaa caagcggctaaagatgaaattgatcaattacaagcaacgcaaacaaatgttatcaataat gatcagaacgctacaacagaagaaaaagaagcagctattcaacaattagcaacagcagtt acagacgcgaaaaataatattacagctgcaactgatgataatggtgtagatcaggcgaaa gacgctggaaagaattcaattcaaagcacgcaaccagcaacagcggttaaatcaaatgct aaaaatgatgttgatcaagctgtgacaactcaaaatcaagcaattgataatacaactggt gctacaactgaagagaaaaatgcagcaaaagatttagttttaaaagctaaagaaaaagcg tatcaagatatcttaaatgcacaaacaactaatgatgttacgcaaattaaagatcaagca gttgctgatattcaaggtattactgcagatacaacaattaaagatgttgcgaaagatgaa ttagcaacaaaagcaaacgaacaaaaagcgcttattgcacaaactgcagatgcgactact gaagaaaaagaacaagcaaatcaacaagtagacgcacaattaacacaaggtaatcaaaat attgaaaatgcacagtcaatcgatgatgtaaacactgcaaaagataatgcaattcaagca attgacccaattcaagcatcaacagatgttaaaacgaatgcaagagcggaattgctaact gaaatgcaaaataaaataactgaaatacttaataataatgagactactaatgaagaaaaa ggtaacgatattggaccagttagagcagcatatgaagaaggtttaaataatattaatgca gcaactactacaggtgatgtaactactgctaaagatacagcagtacaaaaagttcaacaa cttcatgcaaatcctgttaagaaaccagcaggtaaaaaagaattagatcaagctgcagct gataagaaaacacaaatagaacaaacaccaaatgcatcacaacaagaaattaatgatgca aaacaagaagttgatactgaattaaatcaagcgaaaacaaatgtcgatcaatcatcaaca aatgaatatgttgataatgcagttaaagaaggaaaagctaaaattaatgcagttaaaaca tttagtgagtacaaaaaagatgc tttagctaaaattgaagatgcatataatgctaaagta aacgaagcggataactctaacgcatcgacttcaagtgaaattgctgaagcgaaacaaaaa cttgctgaattaaaacaaactgcggatcaaaatgttaatcaagctacttctaaagatgac attgaagttcaaattcataatgacttagataatattaacgattacacaattccaacaggt aaaaaagaatcagctacaacagatttatatgcttatgcagatcagaagaaaaataatatt tcagctgacactaatgcaacacaagatgaaaagcaacaagcaattaagcaagttgaccaa aatgttcaaactgcattagaaagcattaataatggtgtggataatggtgacgttgatgat gcattaacacaaggtaaagcagcaattgatgctattcaagtagatgctactgttaaacct aaagcgaaccaagctattgaagttaaagcagaagatacgaaagaatctattgatcaaagt gaccagttaactgctgaagaaaaaactgaagcattagcaatgattaaacaaattacagat caagctaaacaaggtattactgatgcaacaacaactgctgaagttgaaaaagcgaaagct caaggacttgaagcatttgataacattcaaatcgactcaacagaaaaacaaaaagctatc gaagaattagaaactgcactagaccagattgaagcaggtgtaaatgtcaacgctgatgct acaactgaagaaaaagaagcgtttacgaatgctttagaagacattttatcaaaagcaact gaagatatttctgatcaaactacaaatgcagaaatcgctactgtcaaaaatagtgcgctt gaacaacttaaagcacaacgtattaatcctgaagttaagaaaaatgctttggaagcaatc agagaagtggttaacaagcaaatagaaataattaaaaatgcagatgc agatgcatcggcg aaagaaattgcacgtacggatttaggtagatattttgacagatttgctgataaattagat aaaacacaaacaaatgcagaagttgctgaattacaaaatgtaacgatacctgcaattgaa gcgattgtgcctcagaatgatccagatgctaatgatactaataatggtatagataataat gatgcaacagcaaattcaaatgctaatgcaacaccagaaaatactggacaacctaacgta tctgagacgacagctaatggcaaagcagacgcttctccgacaacaccaaataatagtgat gcggcaacaggtgaaacaacagcaacatcagcaactgatgatgcaaatgataaaccgcaa gctaataacaattctagtgtagatgcatcaacaaacagtccgacaatggataacgatgta actagtaaaccagaagtagaatcaactaataacggcacaactgataaacctgtaacagaa actgataatgcaacgccagcagaaagcacaacaaataacaatagtacaactacagcaaca aacgagaatgcaccaacaggatcaacagcaacggctccaacaactgcgagcacagaagca gcatcatctgctgatagcaaagataatgcatctgtaaatgattcaaaacaaaatgctgaa gtaaataatagtgctgaatctcaatcaactaatgacaaggttgcacaaccaaaatctgaa aataaagctaaggcagaaaaagatggtagtgattcaacaaatcaaagtatggttgaatca acaactgaaacattgccttcagcagacataacagaaccaaatgtaccttctaatacatca aaagataaagaagaaagtacgacaaatcaaactgatgcaggacaacttaagtctgaaact aacgttgcatctaacgaagcagataaatcgccaagcaaagctgatactgaagtttcgaat aaaccatcaa catctgcatcttctgaagcaaaagaaaaaatgacttcaactaatcttagc caaaaagatgatacggcaacagcagatactaatgatacgcaaaaatcagttggttcagct gcaaacaataaagctacgcaaaacgacggtgccaatgcatctccagctacagtttcaaat ggaagcaatagtgctaatcaagatatgcttaatgtaactaacactgacgaccaccaagct aagacaaaatcagctcaacaaggaaaagttaataaagctaaacaacaagctaaaacttta ccagatactggtatgtcacataatgacgatttaccatatgctgaattagctctaggtgca ggtatggcattcttaattagaagattcactaagaaagaccaacaaactgaagaa 202. atgaaactaaaatcatttgttactgccactttagcattgggattattatcaacggtcgga gctgcattaccgagtcacgaagcatctgcagatagtaataacggctataaagaaatgact gtggatggttatcacactgttccttacacaatttcagtagatggtattactgcattacat cgaacttactttatcttcccagaaaataaaaatgttctttatcaagaaattgacagtaaa gtaaaaaatgaattagcttctcaacgtggtgttacaacagaaaaaattaataatgcccaa acagcaacttatacgcttactttgaatgatggtaataaaaaagtagtgaatctaaagaaa aatgacgacgctaaaaattcaattgatccaagtacaatcaaacagatacaaattgtagtt aaa 203. atggctattaaaaagtataagccaataacaaatggtcgtcgtaatatgacttcgttagat ttcgcagaaatcacgaaaactacacctgaaaagtcattattaaaaccgctaccgaaaaaa gcgggacgtaacaaccaaggtaaatt gactgtaagacaccatggtggtggacacaaacgt caataccgtgttatcgatttcaaacgtaacaaagatggtatcaatgcaaaagttgattct attcaatatgatccaaaccgctcagcaaacatcgctttagttgtatatgcagacggtgaa aaacgatatatcattgctcctaaaggattagaagtaggtcaaatcgttgaaagtggtgct gaagctgacatcaaagttggtaacgcattaccattacaaaacattccagttggtacagta gtacacaacatcgagcttaaacctggtaaaggtggacaaatcgctcgttcagctggtgca agtgctcaagtacttggtaaagaaggtaaatacgtattaatcagattaagatctggtgaa gttcgtatgatcttatctacttgccgtgctacaatcggtcaagttggtaacctacaacac gaattagttaacgttggtaaagccggacgttcaagatggaaaggtatccgtccaacagtt cgtggttctgtaatgaaccctaacgatcacccacacggtggtggtgaaggtcgtgctcct atcggtagaccatctccaatgtcaccatggggtaaacctacgcttggtaagaaaactcgt cgtggtaaaaaatcatcagacaaacttatcgttcgtggacgtaagaaaaaa 204. atgttagtaaatacgtttaacccatttgataatttattattatcgtctttaattgcagca ataccgattgtactgtttttactatgtttaactgtttttaaaatgaaaggtatttatgca gctattacaacacttgttgtaacattactaattgcaataccatttttcaaattgccagtt ggtatcgcttctggtgcagtagtcgaaggtttcttccaaggtatcattccgattggctat atcgttatgatggcagtattgttatacaaaattactgttgaatctggacaattt ttaaca attcaagatagtattacaaatatttcacaagaccaacgtattcaagttttacttattgga tttgcattcaacgcatttttagaaggtgcagcaggatttggtgtaccaattgcaatttgt gcacttttattaacacaattaggatttaatccattaaaagctgcgatgttatgtttagtc gcaaatgcagcgtctggtgcttttggtgcgattggtatccctgtaggtgttgtagaaacg ttgaaattacctggagatgtttcagtattaggtgtttctcaatcagcaactttaacattg gcaatcataaatttcattattccattcttacttatctttattattgatggttttagaggt gttaaagaaacattaccagcaattttagtagtttcaatcacttatacacttactcaagga ttattaactgtattcagtggacctgaattagcagatattattccaccgttattaacaatg ttagcattagcagtattttctaaaaaattccaaccaaaacacatttatcgtgttaataaa gatgaagaaattgaacctgcaaaagcacattctgcaaaagcagtattacatgcatggagc ccattcattgtattaacagtcattgtaatgatttggagtgcgccattctttaaaaactta ttcttaccaaatggtgctttatcatcattagtatttaaattcaacttacctggaacaatc agcgaagttacgcataaaccattagtattgactttaaatattattggacaaacaggtaca gctattttattaactattattattacaattttaatgtctaaaaaggttaactttaaagat gcaggtagattattcggcgttacatttaaagagttgtggttaccagttcttacaatttgt ttcatcttagcaatttctaaaatcacaacttatggtggtttaagtgcagcaatgggtcaa ggtattgctaaagcagg taatgtcttcccagttctatcaccaattttaggttggataggt gtgtttatgacaggatcagttgtaaataacaactcattatttgcaccaattcaagcttct gttgcacaacaaattggaacaagtggttcacttcttgtatctgctaatacagttggtggt gtagcggcaaaattgatttcaccacaatcaattgcaattgcaactgcagcagtaaaacaa gttggtaaggaatcagaattattaaaaatgacattgaaatacagtgtatgtttactaata ttcatctgtatttggactttcatcttgtcattatta 205. atgcttaaaaataaaatattaactacaactttatctgtgagcttacttgcccctcttgcc aatccgttattagaaaatgctaaagctgctaacgatactgaagacatcggtaaaggaagc gatatagaaattatcaaaaggacagaagataaaacaagtaataaatggggcgtgactcaa aatattcaatttgattttgtaaaggataaaaaatataacaaagatgctttgatattaaag atgcaaggattcattagctctagaacaacatattacaactataaaaaaactaatcatgtt aaagctatgcgatggccattccaatataatattggtttaaaaacaaatgataaatatgtt tctttaattaattatttacctaaaaataaaattgaatctacaaacgtgagtcagatatta ggatacaatatcggtggtaatttccaatcagccccatcactcggtggtaatggatcattt aactattctaaatcgattagctatacacaacaaaattatgtaagtgaagtagaacaacaa aactcaaaaagtgttttatggggcgtcaaagcgaattcattcgccactgaatcaggtcaa aaatcagcctttgatagcgatttatttgtaggctacaaacctcatagtaaagatcctaga gattatttcgttccagacagtgagttaccacctcttgtacaaagtggatttaacccttca tttatcgccacagtatctcatgaaaaaggttcaagcgatacaagcgaatttgaaattact tacggaagaaacatggatgtcactcatgccattaaaagatcaacgcattatggcaacagt tatttagacggacatagagtccataatgcatttgtaaatagaaactatactgtgaaatac gaggtcaattggaagactcatgaaatcaaggtgaaaggacagaat 206. atgaaaatgaataaattagtcaaatcatccgttgctacatctatggcattattattactt tctggtactgctaatgctgaaggtaaaataacaccagtcagcgtaaaaaaagtcgatgac aaagttactttatacaaaacaacagccacagcagattctgataaatttaaaatttcacag attttaacatttaatttcatcaaagataaaagttatgataaagatactttagtacttaaa gctactgggaatattaactcaggctttgtgaaacctaatcctaatgactatgacttttca aaattatattggggagctaaatacaatgtatctataagctcacaatctaatgattcagta aacgtcgttgattatgcaccaaaaaatcaaaatgaagagtttcaagttcaaaatacttta ggctatacatttggtggtgacattagtatctctaatggtttatctggtggacttaatgga aatacagctttttctgaaacaattaattataaacaagaaagttacagaacaacattaagt cgcaacacaaattataaaaatgttggctggggagttgaagcacataaaattatgaataat ggttggggaccttatggaagagatagcttccacccaacatatggtaatgaactcttctta gctggcagacaaagcagtgcatacgctggccaa aacttcatagcgcaacaccaaatgcca ttattatctagaagtaacttcaatccagaatttttaagcgtactatcacacagacaagat ggcgctaaaaaatctaaaattacagtaacttatcaacgtgaaatggatttataccaaatt cgttggaatggcttctactgggcaggcgcaaattataaaaactttaaaactagaacattt aaatcaacatatgaaattgattgggaaaatcacaaagtgaaattgttagatacaaaagaa actgaaaacaataaa 207. atgaatagagagatgttgtatttaaatagatcagatattgaacaagcgggaggtaatcat tcacaagtttatgtggacgcattaacagaagcattaacagcccatgcgcacaatgatttt gtacaaccgcttaagccgtatttaagacaggatcctgaaaatggacacatcgcagatcga attattgcaatgccaagtcatatcggtggtgaacacgcaatttcaggtattaagtggata ggtagtaagcacgacaatccatcgaaacgtaatatggagcgtgcaagtggcgtcattatt ttgaatgatccagaaacgaattatccaattgcagttatggaagcaagtttaattagtagt atgcgtactgcagcagtttcagtgattgcagcaaagcatttggctaaaaaaggatttaaa gacttaacaatcattggatgcgggctaatcggagacaagcaattacaaagtatgttagag caattcgatcatattgaacgcgtgtttgtttacgatcaattctctgaagcatgtgcacgc tttgttgatagatggcaacaacagcgtccggaaattaattttattgcgacagaaaatgct aaagaagcagtatcaaatggtgaagtagtcattacatgtaccgtaacggatcaaccatac attgaatatgattggttacaaaagggtgcatttatt agcaacatttctatcatggatgtg cataaagaagtctttattaaagctgacaaagtcgtagtagatgactggtcacaatgtaat cgagaaaagaaaactattaaccaattggtgttagaaggtaaattcagcaaagaagctctt catgctgaactaggacaacttgtgacaggtgacataccaggacgtgaagacgatgatgag atcatattacttaatccgatgggtatggctatcgaagatatttcaagtgcttattttatt tatcaacaggcacaacaacaaaatattgggacaacattgaacctatat 208. atgaaaaaaattatggttattttcggtacgagacccgaagcaataaaaatggcaccatta gtaaaagaaattgatcataatgggaactttgaagcgaacattgtgattacagcacaacat agagatatgttagatagtgtgttaagtatatttgatattcaagctgatcatgatttaaat attatgcaagatcaacaaacattagcaggccttacggcgaatgcacttgctaaacttgat agcatcattaatgaggaacaaccggatatgattttagtacatggtgatactacaacgact tttgtaggaagtttggcagcattttatcatcaaattccggtcggacatgtagaagctgga cttcgaacacatcagaaatactcaccatttcctgaagagttaaatcgagtcatggtaagt aatattgctgaattgaattttgcgccaacagtaattgcagctaaaaatttactttttgaa aacaaagacaaagagcgtatctttattactggaaatacagttattgacgcattgtcaaca acagttcaaaatgattttgtttcaacgattattaataaacataaaggcaagaaagttgtt ttactaacagcgcatcgtcgtgaaaatattggggaaccgatgcatcagatttttaaagca gtaaga gatttggcagatgaatataaagatgttgtcttcatttatccaatgcatcgtaat ccaaaggtaagagcgattgccgaaaaatatttatctgggagaaatcggattgaattaatt gagccattagatgcgattgagttccataattttacaaatcaatcgtacctcgtgctgaca gattctggtggtattcaagaggaggctcctacatttggaaaacctgtgttggtattaagg aatcatacagagcgtcccgaaggcgttgaggcgggaacatcgagagtaattggcacagat tatgacaatattgttcgaaatgtgaaacaattgattgaggatgatgaagcgtatcaacgt atgagtcaagcgaataatccatatggtgatggacaagcatcacgacgtatttgtgaagca atagaatattattttggattgcgcacagacaagccggatgaattcgtacctttacgtcac aaa 209. atgattatgggtaatttgagatttcaacaggaatattttcgtatatacaaaaataataca gaatcaacgacacaccgtaatgcgtattgggttaaactcgctaaaaatgttgaagctact aaaatgatgtatgcattatcgacaattgtgcaacaacatgcatctataagacattttttt gatgttactaccgatgacaatttaacaatgatacttcatgaatttctgccttttattgag ataaaacaagttccatcttcttccgcaaactatgatttagaagctttttttaagcaagaa ttaagtacttaccattttaatgattcacctttattcaaagttaaattgtttcagttcgct gatgctgcatatatactattagattttcatgtgtccattttcgatgatagtcaaattgat atttttcttgatgatttatgcaatgcatatcgtggcaatactgttattaacaatactcga cagcatgcacatataaataga aatgatgataaagacaatcaagatgcatcgcatatagca ttagactcaaactattttcggttagagaataactctgacatccatattgatagttatttt ccaattaagcatccatttgaacaagctttatatcaaacgtatttgattgatgatatgaca tcaatagatatggcatcgttggctgttagtgtgtatttagctaatcatataatgagtcaa caacatgatgtcacattaggtatacatgtaccatcacatttaccaaatgatttacacgga aatattgtgccgttaacgttaacaatcgatgcaaaagatgtatgtcaacgttttacaaca gattttaataaatgtgtgttgcaaaatatgtcgcaattacagtgcgcgaagtcttcgctt tcactagagactatttttcattgttatcatcatatgatgtcttgttgtaatgatgttatt gaggatgtacatcaaatacatgatgcacatacatctttagcggatattgaaatttttcca catcaacacgggttcaaaattatatataacagtgcagcatatgatttgctctcaatcgag acgctgagtgacttagttcgaaatatttatttgcaaattactgaagaaaatggaaataaa cgaacaactgtagatgaacttaatttgatgacagaacgtgatattcaattatatgacgat atcaatttaagtttgcctgagatagatgatgcgcaaacagttgttaccttatttgagcaa caagttgaagcaacgccgaatcatgtcgctgtgcaatttgacggagtgtttataacatat caaacattgaatgcacgcgcgaatgatttagcacaccgtttgagaaaccagtatggtgtt gaacctaatgatcgtgtcgctgtcatagctgaaaaaagtattgagatgataatagcgatg ataggtgtgttgaaagctggtggggcttacgtgccaattgatccg aactatccaagtgat cgtcaggagtacattttaaaagatgtaacgcctaaagttgtaataacgtaccaagcttta tatgaaaatggtaaacaaaatattaatcacattgatttgaataagatagcgtggaaaaat attgataatctttctaaatgtaacacgttagaagatcatgcttatgttatttacacgtcg gggacaactggtaaccctaaagggacactaattccgcaccgaggtattgttcgcttggtc catcaaaatcattatgtaccattaaatgaagagacgacgattttgttatcaggaactata gcctttgatgctgcaacatttgaaatatatggtgcattgctcaatggtggaaagctgatt gttgctaaaaaagaacaattattaaatccaatagcggtagaacaattaatcaatgaaaat gacgttaatactatgtggttaacctcctcattatttaatcagattgctagtgaacgaata gaagtattggtatcgttaaagtatttattaattggtggagaagtattgaatgctaagtgg gtggatttgcttaatcaaaaaccgaagcatcctcaaattattaatggttatggaccaact gaaaatacaacatttacaacgacgtataatatacctaacaaagttccaaatcgtattcct attggtaaaccgattctgggtactcatgtttatatcatgcaaggcgagcgtcggtgtggc gttggtattcctggagaattatgtacaagtggctttgggttagctgcaggttatttaaat cagccagaattgacagcagataaatttatcaaagattcaaatataaatcagctgatgtat agaagtggtgatatcgttcgtttgttacccgatggcaacatagattatttatatcgaaag gacaaacaagttaagattcgagggtttaggattgagttgtcagaggttgagcatgcgctc gagcgtat acaaggtattaataaagcagttgttattgttcaaaatcatgatcaagatcag tatatcgttgcttattatgaagcgatgcatacattatcacataataagattaaatcacaa ttacgtatgaccttaccggagtacatgataccagttaatttcatgcatattgagcaaatt cctattactattaatgggaaattagataagaaggcattgcctatcatggactatgtcgat acggatgcctatgtagcaccgagtacagataccgaacacttgctatgccaaatttttgca gatattttacatgtgaatcaagtaggtattcatgataatttctttgaattaggtggccat tcattaaaagcaacgttagtggtgaatcggatagaggcatctactgggaaacgattacaa attggtgatttattacaaaagccaactgtatttgaactagcacaagcgattgctaaggtt caagaacaaaactatgaagtgattccagaaactatagttaaagatgattatgtgctgagc tctgcacaaaagcgtatgtatttattatggaaatcaaaccataaagatacggtgtataac gtaccttttttatggcggttatcatcagaacttaatgtagctcaattgcgacaagcagtg cagcgtttgatagcgcgacatgagattttacgaacacaatatattgttgtagatgatgag gttcgacaacgtattgtggcagatgttgcagttgactttgaagaagttaacacgcatttt acggatgaacaagaaatcatgcgccaatttgtagcaccttttaatttggaaaagccaagt caaattagagtgagatacattagaagtcccttacatgcatacctctttatagatacgcat catatcattaatgacggtatgagtaatatacaattaatgaatgatcttaacgcactttat caacataaattattgttaccacttaaattgca atataaagactatagtgagtggatgtcg catcgtgatatgacgaaacatagacaatattggttatctcaattcaaagatgaagtacct attttaagcttaccgacagactatgttagaccaaatattaaaacgacaaatggagcaatg atgtcatttacaatgaatcaacaaatgagacagctacttcaaaagtatgtagaaaagcat caaattactgattttatgttctttatgagtgtggtcatgacgttgttaagtagatatgct cgaaaagatgatgttgttgtcggtagtgtgatgagtgcgcgtatgcataaaggcacggag caaatgctaggcatgtttgctaatacgttggtatatagagggcaaccgtcacctgataaa atgtggacacagtttttacaagaggttaaggaaatgagtttggaggcatacgagcatcaa gaatacccattcgaatgtttagtaaatgacttagatcaatcacatgatgcctcacggaat ccattatttgatgtcatgttagtactacaaaacaatgaaacgaatcatgctcattttggg catagtaaattaacacacattcaacccaaatcagtgacggcgaaatttgatttatctttc atcattgaagaagatcgcgatgactatacaatcaatatcgagtataataccgatttatat cactcagaaacagttcgtcacatgggtaatcaatgtatgattatgattgattatattttg aagcatcaagatacactacaaatttgtgatataccaaacggcacggaggaacttctaaat tgggtcaatacgcatgttaacgatcgaatgcttaatgtcccgggaaataaatctatcata agttactttaatgaagttgtctcacgacaaggtaatcatgttgcgctagtcatgaatgat ttgacaatgacgtatgaaacattacgcaactatgtggatgccattgcgcacatgct ccta tcaaatggtgtgggcaatggtcaacgggttgccttgtttacagaacgtagttttgaaatg attgcggcgatgttggcgacagttaaagtaggtgcatcttatatacctatcgatattgat tttccgaataaacgacaaggtgcaattttggaggatgctaaagtaactgcagtcatgtct tacggcgttgaaattgaaacgacattaccagtcattcaattggaaaatgctaaaggcttt gttgaatcaaaggaaaatgaacaatatgatgatttacatggcaatcaacttgaaaacaca gcgatgttagataatgagatgtatgctatttacacatctggtacgaccgggatgcctaaa ggggttgccatacgacaacgaaatttgttgaatttagtgcatgcatggtcaactgaattg caattaggcgacaatgaagtatttttgcaacatgcaaatattgtttttgatgcatcagtt atggagatttattgttgtttgttaaatggtcatacgcttgtgattccagatagagaggaa cgtgttaatccagaacagttacaacaactcattaataagcatcgtgtgacggttgcgtcg attccgttacagatgtgtagtgttatggaagacttttatattgaaaagttgattacaggc ggggcaactagtacggcatcctttgttaaatatattgagaagcattgtggcacgtatttc aatgcctatggaccatctgagtcaacagtcatcacatcgtattggtcacatcattgtggt gatttgatacctgagacgattccaattggcaaacccttatctaacatccaagtgtatatt atgtcagatggtttgttatgcggtattggtatgccaggcgagttgtgtattgcaggtgat agtttagcgataggatatattaatcgtccagaattaatggctgataaatggcaaaataat ccatttggtaaaggaaagt tgtatcatagtggtgatttagcacgttatacatctgatggt caaattgaatttttaggaagaatagataaacaagtgaaagttaacgggtaccgtattgaa cttgatgaaattgaaaatgcaatattagctattcgtggtatatctgattgtgttgtaaca gtaagtcactttgatacgcatgatatattgaatgcttattatgtcggagagcaacaagtg gaacaggatttgaagcaatatttaaatgatcagctgcctaagtatatgattcctaagact ataacgcatatcgattgtatgccattaaccacgaatgacaaggtggatactacgcgtttg ccaaatccatcacctatacaacagtctaataaagtgtatagcgaaccctctaatgaaatt gagcagacatttgttgatgtatttggagaggtattgaaacaaaatgatgtcggtgttgac gatgatttctttgaacttggtggtaactcattagaggcgatgttagttgtctcgcattta aaacgatttggccatcatatttcaatgcagacattataccaatataaaaccgtgcgacag attgttaattatatgtaccaaaatcaacaatcattagttgcattaccggataatctttcg gaattacaaaagattgttatgtctcgttataacttgggtattttagaggatagtctaagt catcgacctctaggaaatacactattgactggcgcgacaggttttttaggtgcttatctg attgaagtactacaaggatacagtcatcgcatttattgtttcatacgtgctgataatgag gaaatagcatggtataagttgatgacgaatttaaatgattatttttcagaagagacggtt gaaataatgttatcaaacattgaagtcattgttggtgatttcgagtgtatggatgatgtt gttttaccagaaaacatggatacgattattcatgcaggtgctc gtacagatcactttggt gatgatgatgaatttgaaaaagtaaatgttcaaggtactgttgatgtcatacgtttggca caacaacatcatgcaaggttaatatatgtgtctacgataagtgtgggaacttattttgat atagacacagaagatgtgacattttcagaagcggatgtctataaagggcaactactaaca tcaccatatacacggagcaaattttatagtgaattaaaagtattagaagctgtaaataat ggcttagatggtcggattgtacgtgttggtaatttgacgaatccttacaatggaagatgg catatgagaaatataaagactaaccgtttttcaatggtaatgaatgatttgttacaactg gattgtatcggggttagcatggctgaaatgcctgtagatttttcttttgtggatacgact gcaagacaaattgtcgcattagcacaggtcaacacaccacaaatcatttaccatgtgcta tcacctaataaaatgccggtgaaatctttgttagaatgcgttaagcgcaaagaaattgaa ctcgtcagcgatgaatcatttaatgaaattttacagaaacaagacatgtacgaaacgatt ggattaactagtgttgaccgtgaacaacaactagcaatgatagatacaacattaacatta aaaataatgaatcacatcagtgaaaaatggccaacgataactaacaattggctgtatcat tgggcacaatatatcaaaacaatattcaataag 210. atgaccaaagaacaacaacttgcagaacgaattattgctgcagtaggtggtatggataat atagatagtgtcatgaactgtatgacacgtgtgcgtattaaagtattagatgagaataaa gtagatgaccaagaactaaggcatattgatggtgtcatgggtgttatacacgatgaacgc attcaagttgtggttggacctggtacag tcaataaagtggctaatcatatggcggaatta agtggtgttaaactaggtgacccaataccacaccatcacaatgatagtgaaaaaatggac tataaatcatatgcagctgataaagcaaaggcgaataaggaagcgcataaagcaaaacaa aagaatggtaagttgaataaagtattgaaatcaattgccaatatctttataccgttgatt cctgcatttattggagctggattaattggtggtattgcagcagtactgagtaacttaatg gtggcaggctatatttcaggtgcttggattacgcaacttataacagtatttaatgtcatt aaagacggtatgttagcatacttagctattttcactggtattaatgcggctaaagaattt ggtgcgacaccaggacttggtggcgtgattggtggtacaacgttattaacgggtattgct ggtaaaaatattttaatgaatgtcttcactggagaaccattgcaacctggacaaggtggg attattggcgttatttttgccgtttggattttaagtattgtcgaaaagagattacataaa attgtgccaaatgcgattgatattattgtaacgccgactattgcattgttgattgtagga ctattaactatctttatctttatgccattagcaggttttgtttcagacagtttagtttca gtagttaacggaattattagtattggtggcgtatttagtggatttatcattggtgcaagc ttcctaccgttagttatgttagggcttcatcatatttttacgccaattcatatagaaatg attaaccaatcaggtgctacttacttattgccaattgcagcgatggctggtgctggacaa gtaggtgccgcattagcactttgggtaagatgtaaacgcaacacaacattacgtaatact ttaaaaggtgcattgccagttggtttcctaggtatcggagaaccattaatct atggtgtg actttgccattaggtcgacctttcttaactgcttgtattggtggtggtattggtggcgct gtaataggtggaattggacatattggtgccaaagcaataggcccaagtggtgtgtcacta ttaccattaatctcagataatatgtatttaggttatattgcaggattacttgctgcgtat gctggtggattcgtttgtacatatttatttggaacgacaaaggcgatgcgacagacagat ttgttgggtgat 211. atgtctaaaattttaaaatgtatcacgttagccgtggtaatgttattaatcgtaactgca tgtggccctaatcgttcgaaagaagatattgataaagcattgaataaagataattctaaa gacaagcctaaccaacttacgatgtgggtggatggcgacaagcaaatggcgttttataaa aaaattacggatcaatatactaaaaaaactggcatcaaagtaaagcttgtaaatattggt caaaatgatcaactagaaaatatttcgctagacgctcctgcaggaaaaggtccagatatc tttttcttagcacatgataatactggaagtgcctatctacaaggcttagctgctgaaatc aaattatcaaaagatgagttgaaaggtttcaataagcaagcacttaaagcgatgaattat gacaataagcaactagcattgccagctatcgttgaaacaaccgcacttttttataataaa aaattagtgaaaaatgcaccgcaaacgttagaagaagttgaagctaatgctgccaaacta actgatagtaaaaagaaacaatacggtatgttatttgatgctaaaaatttctattttaat tatccgtttttattcggcaatgatgattatattttcaagaaaaatggcagtgaatatgat attcatcagctaggactaaattcaaaacatgtcgtcaagaatgctgaacgattacaaa aa tggtacgacaaagggtatcttcctaaggcagcaacacatgatgtcatgattggtcttttt aaagaaggaaaagtaggacaatttgtcactggaccgtggaacattaatgaatatcaagaa acgtttggtaaagatttaggagtaacaacattacctacagatggtggcaaacctatgaaa ccatttctaggtgtacgtggttggtatttatctgaatatagtaaacataagtattgggct aaagatttaatgctgtatatcactagtaaagatacattacaaaaatatacagatgaaatg agcgaaattactggacgtgttgacgtgaaatcatctaatccaaatttaaaagtgtttgaa aagcaagcacgtcatgctgaaccgatgcctaatattcctgaaatgcgacaagtttgggaa ccgatgggcaatgcaagcatatttatttcaaatggtaagaatcctaaacaagcgttagat gaggcgacgaatgatataacgcaaaatattaagattcttcatccatcacaaaatgataag aaaggagat 212. gtgaaagcattgaaattatatggcgtggaagatttacggtatgaggataatgaaaagcca gtcattgaaagtgcgaatgacgttattattaaagtacgagcgactggcatatgtggttca gacacgtcacgatacaaaaaaatggggccatacattaaaggtatgccatttggtcatgaa ttttcaggtgtagtagatgccattggaagtgatgttacgcatgttaatgtgggcgacaaa gtgacaggttgcccagcaataccttgttatcaatgcgagtattgtttaaaaggtgaatat gcacgatgtgaaaagttattcgtcattggctcatatgaacctggatcgttcgcggaatat gtcaaattgccagcgcaaaatgttttaaaggttccagacaatgttgattacattgaagca gcaatg gttgagccatcagccgttgttgcgcatgggttttataaatcgaatatacaacct ggtatgactgttgcagtaatggggtgtggcagtataggtttgttagctattcaatgggca cgaatatttggtgctgcacatatcatcgctatagatatagatgcgcataaactagatatt gcaacatcattgggcgcacatcaaacaatcaattcaaaagaagaaaatcttgagaaattc atcgaaaatcattacgccaatcaaatcgatttagctatagaatcatcaggtgctaaagtt acgattggtcaaatattgacgctacctaaaaaaggtggcgaggtggtattactcggaata ccatatgatgatattgagattgatcgcgttcattttgaaaaaattctgcgtaacgagttg acagtatgtggctcttggaactgtttgtccagtaattttccgggcaaagagtggacggca accttacattatatgaagacgaaagatattaatgtaaagcctattatttctcatttttta ccgttagaaaaaggcccggagacatttgataaattagttaacaagaaagaacgatttgat aaagtcatgtttacgatttat 213. atgcaagcattacaaacatttaattttaaagagctaccagtaagaacagtagaaattgaa aacgaaccttattttgtaggaaaagatattgctgagattttaggatatgcaagatcagac aatgccattagaaatcatgttgatagcgaggacaagctgacgcaccaatttagtgcatca ggtcaaaacagaaatatgatcattatcaacgaatcaggattatacagtctaatcttcgat gcttctaaacaaagcaaaaacgaaaaaatcagagaaaccgctcggaaattcaaacgatgg gtaacatcagatgtcctaccagctattcgcaaacacggtatatacgcaacagacaatgta att gaacaaacattaaaagatccagactacatcattacagtgttgactgagtataagaaa gaaaaagagcaaaacttacttttacaacaagaaatcggagaactaaaacccaaagcagac tatgtagatgaaatcttaaagtcaactggcacattagccacaactcaaatcgcggcagac tacggtatatcagcacaaaagttaaacaaactactacacgaagctagactacaacgaaaa gtaaataaacagtgggtgctttactcagaacacatgggcaagagttacacagaatcagac actatagcaattgtacgctctgacggtagagaagacacagttttacaaactagatggaca caaaaaggcagattgaaaatacatgaaatcatgactgaattcggttatgaagctaattta gggggagcg 214. atgaaattaaaatcattagcagtgttatcaatgtcagcggtggtgcttactgcatgtggc aatgatactccaaaagatgaaacaaaatcaacagagtcaaatactaatcaagacactaat acaacaaaagatgttattgctttaaaagatgttaaaacaagcccagaagatgctgtgaaa aaagctgaagaaacttacaaaggccaaaagttgaaaggaatttcatttgaaaattctaat ggtgaatgggcttataaagtgacgcaacaaaaatctggtgaagagtcagaagtacttgtt gctgataaaaataaaaaagtgattaacaaaaagactgaaaaagaagatacaatgaatgaa aatgataactttaaatatagcgatgctatagattacaaaaaagccattaaagaaggacaa aaagaatttgatggtgatattaaagaatggtcacttgaaaaagatgatggcaaacttgtt tacaatatcgatttgaaaaaaggtaataaaaaacaagaagttactgttgatgctaagaac ggtaaagtatta aagagtgagcaagatcac 215. atgaaaatgaaaaatattgcaaaaataagtttgttattaggaatattagcaacaggtgta aacactacaacggaaaaaccagttcatgccgaaaagaaacctattgtaataagtgaaaat agcaaaaaattaaaagcttattataatcaacctagtattgaatataaaaatgtgacaggt tatatcagtttcattcaaccaagtattaaatttatgaatatcatagatggtaattctgtt aataatattgctttaattggcaaagataagcaacattatcatacgggtgtacatcgtaat cttaatatattttacgttaatgaggataagagatttgaaggtgcaaagtactctattggg ggtatcacgagtgcaaacgataaagctgtcgacctaatagcagaagcaagagttattaaa gaagatcatactggtgaatatgattatgactttttcccatttaaaatagataaagaagcg atgtcattgaaagagattgattttaaattaagaaaataccttattgataattatggtctt tacggtgaaatgagtacaggaaaaattacagtcaaaaagaaatactatggaaagtataca tttgaattggataaaaagttacaagaagaccgtatgtccgatgttatcaatgtcacagat attgatagaattgaaatcaaagttataaaagca 216. mrktkivctigpaseseemieklinagmnvarlnfshgsheehkgridtirkvakrldki vailldtkgpeirthnmkdgiielergnevivsmnevegtpekfsvtyenlindvqvgsy illddglielqvkdidhakkevkcdilnsgelknkkgvnlpgvrvslpgitekdaedirf gikenvdfiaasfvrrpsdvleireileeqkanisvfpkienqegidniaeilevsdglm vargdmgveippekvpmvqkdl irqcnklgkpvitatqmldsmqrnpratraeasdvana iydgtdavmlsgetaaglypeeavktmrniavsaeaaqdykkllsdrtklvetslvnaig isvahtalnlnvkaivaatesgstartiskyrphsdiiavtpseetarqcsivwgvqpvv kkgrkstdallnnavatavetgrvsngdliiitagvptgetgttnmmkihlvgdeiangq gigrgsvvgttlvaetvkdlegkdlsdkvivtnsidetfvpyvekalgliteengitsps aivglekgiptvvgvekavknisnnmlvtidaaqgkifegyanvl 217. mqfdnidsalmalkngepiivvddenrenegdlvavtewmndntinfmakearglicapv skdiaqrldlvqmvddnsdifgtqftvsidhvdtttgisayertltakklidpsseakdf nrpghlfplvaqdkgvlarnghteaavdlakltgakpagviceimnddgtmakgqdlqkf kekhqlkmitiddlieyrkklepeiefkakvkmptdfgtfdmygfkatytdeeivvltkg airqhenvrlhsacltgdifhsqrcdcgaqlessmkyinehggmiiylpqegrgigllnk lrayelieqgydtvtanlalgfdedlrdyhiaaqilkyfniehinllsnnpskfeglkqy gidiaerievivpetvhnhdymetkkikmghli 218. mkmkklvkssvassiallllsntvdaaqhitpvsekkvddkitlykttatsdndklnisq iltfnfikdksydkdtlvlkaagninsgykkpnpkdynysqfywggkynvsvssesndav nvvdyapknqneefqvqqtlgysyggdinisnglsgglngsksfsetinykqesyrttid rktnhksigwgveahkimnngwgpygrdsydptygnelflggrqsssnagqnflpthqmp llargnfnpefisvlsh kqndtkkskikvtyqremdrytnqwnrlhwvgnnyknqntvtf tstyevdwqnhtvkligtdsketnpgv 219. mkkkallplflgimvflagcdyskpekrsgffyntfvdpmknvldwlgnnllndnyglai iilvlviriillpfmlsnyknshmmrqkmkvakpevekiqekvkrartqeekmaanqelm qvykkydmnpiksmlgclpmliqlpiimglyfvlkdqlvdglfkyphflwfdlgrpdiwi tiiagvlyfiqayvssktmpdeqrqmgymmmvispimiiwislssasalglywsvsaafl vvqthfaniyyekvakkevqpfieayerehnggsnkkgkntqvvskkkkk 220. mnlfrqqkfsirkfnvgifsaliatvtfistnpttasaaeqnqpaqnqpaqpadantqpn anagaqanptaqpaapanqgqpavqpanqggqanpaggaaqpntqpagqgnqadpnnaaq aqpgnqatpanqagqgnnqatpnnnatpanqtqpanapaaaqpaapvaanaqtqdpnasn tgegsinttltfddpaistdenrqdptvtvtdkvngyslinngkigfvnselrrsdmfdk nnpqnyqakgnvaalgrvnandstdhgnfngisktvnvkpdseliinfttmqtnskqgat nlvikdakkntelatvnvaktgtahlfkvptdadrldlqfipdntavadasrittnkdgy kyysfidnvglfsgshlyvknrdlapkatnnkeytinteignngnfgaslkadqfkyevt lpqgvtyvnnsltttfpngnedstvlknmtvnydqnankvtftsqgvttargthtkevlf pdkslklsykvnvanidtpknidfnekltyrtasdvvinnaqpevtltadpfsvavemnk dalqqqvnsqvdnshyttasiaeynklkqqadtilnedanhvktanrasqadidglvtkl qaalidnqaaiae ldtkaqekvtaaqqskkvtqdevaalvtkinndknnaiaeinkqtta qgvttekdngiavleqdvitptvkpqakqdiiqavttrkqqikksnaslqdekdvandki 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tctgacagtgcgtcaacatcaacgagcgagagcgactccgatagcgcaagtacatcgttg agtggctcatcaagtacaagcgtttcagattcaacaagcgcgtcaacatcagaaagtgca tcaacgtcaacgagcataagtgactcaaacagtacaagtacgtcattaagtgaatcgaca agtacgagtctttcagaatcaacgagtacgtctacatccgacagtgcatccacatcaatg agtgtaagcgactcaaatagtgccagcatatctttaagtgagtcgacaagcacaagcgtt tcagattcaacaagtacatcgacatcagaaagtgcatcaacgtcaacgagcgagagtgac tccaatagcgcaagtacgtcattaagtgagtcgacaagcacaagcgtttcagattcaaca agcacatcgacatcagacagtgcgtcaacatcaacgagcgtaagtgattccaatagcgca agtacgtcattgagtgagtcgacaagcacaagcatctcagattcaacaagcacgtcgaca tcagacagtgcgtcaacatcaacaagtgtgagtgagtcaagcagtacaagtaagaagtta tc agaatcagcgagtacgtcgatgtctgatagcgcatctgcatcaacgagtgaatcaaac agtacaagtacgtcattaagtggctcgacaagtacgagtctttcaggatcaacgagtaca tcgacttcagaaagtgcgtcaacatcaacgagcgtaagtgactccaatagcgcaagtacg tcattaagtgaatcgacaagtacgagtctttcagactcaacgagtacatcgacatcagat agtacgtctgcatcaacaagtgagagtgactcaaacagtacaagcacatccatgagtgaa tcattaagcacaagcgtttcagattcaacaagtacgtcaacgtcagacagtgcatcaacg tcaacaagtgtgagtgactccaatagcgcaagtacgtcattaagtgattcaacaagtaca agcatttcagactcaacgagtgcgtcgacatcagatagtgcgtcagagtcagcaagcgag agtgaatcaacaagtgaaagtacatcggtaagtgaatcatcaagtacaagcgtttcagat tcaacaagtacatcgacatcagaaagtgcatcaacgtcaacaagcgagagtgaatcaaca agtgaaagtacatcggtaagtgaatcatcaagtacaagcgtttcagattcaacaagtaca tcgacatcagaaagtgcatcaacgtcaacaagcgagagtgaatcaacaagtgaaagtacg tcattaagtggatcatcaagtacaagcgtttcagattcaacaagtacgtcaacgtcagaa agtgcatcaacgtcaacgagtgtgagcgactcaaatagtacaagtacgtcattaagtgaa tcgacaagtacgagtctttcaaactcaacaagtacgtcaacatcagacagtgcatcaacg tcaacgagtgtgagcgactccaatagcgcaagtacatcgttgagtggctcattaagcaca aacgtttcagattcaacaagcacatc gacatcagacagtgcttcaacgtcaacaagcgag agtgactcgaacagtgcaagcacatcgctaagtggatcattaagtacaagcatttcagac tcaacgagtacgtcgacatcagacagtgcgtccacatccacatcagaaagtgcatccaca tcaacgagtgtgagtgagtcagacagtgaaagtacatccatgagtgtgagtgactcgaat agtacaagtacatcattgagtgactcgacaagtacgagcgtttcagactcaacaagaaca tcaacatccgatagtgcatctacatcaaagagtgtaagtgagtcaaacagcgccagtaca tcggtaagtggctcaacaagtacaagcatttcagattcatcaagcacgtccacatcaatg agtacatctgaaactttcacttctcaatctcctataaatagtgaaagtcaatttattggt gatagcttgtctgaagatacaatcgtgactcaatcaaaaaatacgaatatgcttaataaa actggaaaagattatgatttacaagaacaaagaggttatactgattcagaacaacacaat gaaacacaaagtaatcaagctgataatcactcaaacaacctcgatttacttcatcaaaat cgtttacaagataaagtcgttaaacaaccgactaaaggagaagatggagttgtaagcaac ggttttatagtagcagtagcaatagtattggctatcttcggtttggcaaaaaaatctaga aaagacgatgatgatcaagatggtagtaaa 240. atgaaaaaaacagttatcgcttctacattagcagtatctttaggaattgcaggttacggt ttatcaggacatgaagcacacgcttcagaaactacaaacgttgataaagcacacttagta gatttagcacaacataatcctgaagaattaaatgctaaaccagttcaagctggtgcttac gatattcatttcgt agacaatggataccaatacaacttcacttcaaatggttctgaatgg tcatggagctacgctgtagctggttcagatgctgattacacagaatcatcatcaaaccaa gaagtaagtgcaaatacacaatctagtaacacaaatgtacaagctgtttcagctccaact tcttcagaaagtcgtagctacagcacatcaactacttcatactcagcaccaagccataac tacagctctcacagtagttcagtaagattatcaaatggtaatactgctggttctgtaggt tcatatgctgctgctcaaatggctgcacgtactggtgtatctgcttcaacatgggaacac atcattgctagagaatcaaatggtcaattacatgcacgtaatgcttcaggtgctgctgga ttattccaaactatgccaggttggggttcaactggttcagtaaatgatcaaatcaatgcc gcttataaagcatataaagcacaaggtttatctgcttggggtatgt 241. atgaataaaaataaagtgattgtaattggatcaacaaatgtagataaatttcttaatgtt aaaaggtttccaaaacccggtgagacattacatattaatcaagctcaaaaggagtttggt gggggcaagggagccaatcaagccatagcagctagtagattagcagcagatacaacattt atcagtaaagttggtaaagatggcaatgccaactttatattggaagatttcaaaaaagca ggtattcatacacaatatattttaacttcagaaagtgaagaaactgggcaagcatttatc actgttgatgaagcaggacaaaatacgattcttgtttacggtggtgcgaatatgacatta agtgcaactgatgttgagatgagtgtggatgcgtttattggtgcagactttgttgtagcg cagcttgaagttccatttgaggcgatagaacaagcatttaaaattgc tcgtaaacaaaat atcactactgtattaaatcctgcaccggcaattgaattgcctaagtcacttttagagtta actgatataattattccaaacgaaacggaagcagaattattaacaggtatttcaatcaat aatgaaagtgatatgaaagaaacagcaacatattttctcgatttaggtatatctgcagta ttaattactttaggggagcaaggcacgtattgtgcatatcaagaacaatacaaaatgatt cctgcgtgtaatgtaaaagcaatagatacgacagcagcaggagatacatttataggtgct tttttaagtgagttaaataaagatttgagcaatttagaatcggctattcgacttgcaaat caagcgtcgtctctaacggtacaacgaaaaggagcacaagcttctataccaacacgtaaa gaagtagaggcagaatataat 242. atggctcttaaaaaatataagccaattacaaatggtcgtcgtaatatgactactttagat ttcgctgaaatcacaaaaacaacacctgaaaagtcattattacaaccgctaccgaaaaga gcgggacgcaataaccaaggtaaattgactgttcgccatcatggtggtggacacaaacgt caataccgtgttatcgattttaaacgtaacaaagatggaatcattgctaaagttgattca attcaatatgatccaaaccgttcagcaaacattgcattgctagtttatgctgatggtgaa aaaagatatatcatcgcacctaaaggattacaagtaggtcaaactgtcgaaagtggtgct gaggcagatatcaaagttggtaatgctttaccattacaaaatattccagttgggacagta attcataacatcgagttaaaacctggtaaaggtggacaacttgctcgttctgctggtgct agctctcaagtattaggtaaagaaggtaaatatgtattaatcag attaagatctggtgaa gtacgtatgattttatctacatgtcgtgcaacaattggtcaagttggcaacttacaacat gaattagtaaatgttggtaaagcaggacgctctagatggaaaggcgttcgcccaactgta cgtggttctgtaatgaaccctaatgatcacccacacggtggtggtgaaggtcgtgctcca atcggtagaccatctccaatgtcaccatggggtaaacctacgcttggtaagaaaactcgt cgtggtaaaaaatcttctgacaaacttatcgttcgtggacgtaagaaaaaa 243. atgaagtcaaaattcacaattctattatttacaatcttttctacaacagtattagttttg gttattatttataacaaaactcaatcccaatcatacatttcgactcactattctaataat aaaataaaaacaacagcaacactttttttacatggttatggtggtagcgaacgctcagaa acgtttatggtcaaacaagcgttaaataaaaatgtaaccaatgaggtgataaccgctaga gtgagtagtgaaggaaaagtatattttgataaaaaattaagtgaagatgcagcaaaccct attgtcaaagtagaatttaaagataataaaaatggaaattttaaagaaaatgcttattgg attaaagaagttctatcacaactaaaaagtcaatttggaattcaacaatttaattttgta ggacattcaatggggaacatgtcatttgctttttacatgaaaaattatggggacgatcga catttgccacaacttaaaaaggaagttaatatagcgggagtttataacgggattttgaat atgaatgagaacgtgaatgaaattatcgttgataaacaggggaaaccaagtagaatgaat gccgcatatcggcaattgttatcactgcataagatttattgtggtaaggaaatagaagtt ttaaatatcta cggagatttagaagatggctcacattcagatggacgtgtgtcaaatagc tcttctcaatcgcttcaatatttactaagaggtagcactaagtcttatcaagaaatgaaa tttaaaggtgcaaaggcacaacatagtcaattacatgagaataaagatgttgcaaatgaa atcatacaattcttatgggaaact 244. atgaagattggaattgatgccggagggactttaattaaaattgtacaagagcatgacaat cgtagatattacagaactgaattaacaactaatatccaaaaagtcatagattggcttaac aatgaagaaatcgaaacattaaagcttacaggtggaaatgctggagtaatagcagatcaa attcatcattcccctgaaatatttgtagagttcgatgcatcatcaaaaggtttagaaatt ttattggatgaacaaggtcatcaaattgaacattacatttttgctaatgtaggtacaggt acttctttccactattttgatggaaaagaccagcaacgtgttggaggtgtaggtaccgga ggcgggatgatacaaggtttaggctatttattgtccaatataacagattataaagaatta acgaatttagctcaaaatggagatcgtgatgccattgatttaaaagtaaaacatatttat aaagatactgaaccaccaattcctggagatttaacagcagcaaattttggaaatgtatta catcacttagataatcagtttacatcagctaacaaacttgcctctgcaattggcgtcgtt ggtgaagttataacaactatggctattacattagcacgtgaatataagactaagcacgtt gtatatatcggttcatcatttaataacaatcaattactacgtgaagttgttgaaaattac actgttctaagaggatttaaaccgtactatattgagaatggtgctttttcaggcgcttta ggagc actttacctc 245. atgactttaaataaccattttgcatatacatttgaggagagacctaccccaaaattatgg ctttgtaaaccagatggaactagaattgaaagaattgcagatttttcaaaacttggtgga acattcaaattcactaatgtgaacactttacattttgatttgccattgcaagtatttagt gaagatactaagcaaattgaaagaaataaagtagttgatttagtaaaaaataaatactta attgattatagatataacggatatagagatatctttgtaattgatgatattaaaaaatct gctaatgactctgattttattacattaaatttagactcaagagcgtctgaattaaataag aaagctgcaaatgaaattgaattattaggttctactatccctcaaatgatgaacaaaatc ttatcagtttatgctccactatggaaacttggacatgttgatggaaaaattattgatgtt aaacgtgagttaactggttctaatacaactgttaacgctcttattgataatatttgttct ctttttgacgcagttgctatttataacaacattaatagaacaataagcttctatcataaa gacaatgttggtactaatcgtggtttaagagttagggaaaatagttatttaaaatcattt gaagatcaatttgtatcaaaggatatcgttactagattatatccatttggtcaaagtggt ttaacaattcaaagtgttaacccagctggctcttcttatattgaagacttctcttatttc atgtcaccattcaaacgtgataataacagaaatgtattacaacatagtgattatatgtct gatgaattatgtcacgctttgttagattatcaagagttttatgctagtaagaaggatcaa gctggtgaattatctaaacaatatagtgcaattcttaaagagcattcacaagaagacttc agattaaa tcaattaagtgctacacttcaacgactaaatgagcgtgttgaattagttaaa cctaaatcagaatatattgacttaggaacaaaggttaagaatttcaaaatcactgtacct aaatcatcatattatttaatcatgattagaaatgatggtagtttcactagaattaaattc aataataaacagtatgatattccaagtggtgagtggttgtatatcaaacttaaaactggt aagtttaatgacgctactaagtttgagaaacaattagaataccctcttgaaatattaagt gcaaacgctaatttaagagtggtatatactcgttcttctgaaggagattatgaagaagaa gatactaagacaatcgaagaaaaatacaacttagaaaaatataaaattttagtaaaagat caagaaaaagtagtcgcttcaatcgaaagacgattaaaagcttttgaagaccaaaaagca agtgtaatacgttcaatgaatgcaaagaatttcttatctgaaaaactttataatgaacgt gagttatatgtttttgagtctgtttggacggaagaaaatcatacagacgctcaagaatta tatgatgacgctgtaaaacaaatgaaggaacaaaagaaaatcaatagaacgattacagtt gatttagttaacttcattcaatcgcttgaccataaagatgattgggataaattaaatgtt ggagataaagttgttttccaaaacaaaatcttcaatactaaaatcaaagcctatatcact gaaatgcaattagatttccaaactaatcaagtaaaaattactattagtgatatttttgat tacaaagatttagacacaatcatcgctgaaaaattagcccaaactacctctacttcttct caagttgatttccataaacaacaaattagagagcaaaccggaagaattacagatatgact cgtcttatcgaaggtgagtgggacgcaaataa aaagcgtgtgatggctggtaatgaaaca gttgatattggttcacatggtgttaaagtcatttcaaaagagaaccctaacgaattcgta atcatggttggtggcgtaattgctatgactcgtgataacggtgaaacatttaaaactggt attacaccagaaggtatcaatgctgaaatgcttatcggtaagatgatcgttggtgaaact ttaacttttgaaaatgagtctggtacagttaaattcgacaaagatggactttatgttaac tctaaaaacttccatttagtttcaaatgatggagaagaagactacttcgataaattaaaa cgtgaaatgtctgaaaacgctaaacaacaaacagacagaatgttagaagagtataaaaaa gaagtttcacaaactatttctgaagctactgacgttagaaacattgttgataatgcagca gatattcttcaagcagcttttgctgatggagttatcacagatgttgaaaaacgtttgatt tctgaaactcttgctcaacttgaaaaagaaaatagagaattcgaagataaaattaactta gctttaaaccacccttacatcactgaggaagatactattgagttaaataattctatcgtt gaatatagctcaatgtatgaaacacttgttatttctattaatgaaagtgttagtgacaag atgatcacacctcaagagtctgaagaaattaatcaaaatattataaacttcagagaagag atcaaagacatcttatcattagtagaagaaattattgaacgaactaaaaatgctcaacta caagctactttagaagaagcaaaagattatacaacaagagttcgtgacgatattaaagat gaattaaaagacttaaataattcatttaaatctttaaatagtacagttgaagagtcatta caagataatatttttgacgctgctgaattagaagctattaaaacagttgtattagt aact aaatcagaatatcaagatattacaaatagatattcttcaatgtctgcaaatacagattta aaatcggaaagtaaattagatttaacaaaatcttataaaactttagatactagctttaat gactttgttaaatatattgacgaaatgacaatggatagaattgcagatgagactgagaaa gttaattacaaaaagaaatatgatactttacaaaagaacttatcagattatatgaaaaaa tatgataactgtattttggaaatatctaaaaagtattctaatgacgcagcagataaagtg ttaggtgacttcacagctattgctactgaattacaaaatgatttccaagatgttaaagac aattgggctgaattcaagcaaactactcttgagtcatttaaagatggtatagtaactgag gcagaaaaagctcgactaagagtacaattagatatgcttgatcgtgaaagcatggatatt gaagaacgatataaaagcttacttgctaaccaatatactaatactgatattaaaaatcgc ttaactgcttcacgttctccttacttatcagttcatgctagtttaagaaaagtaattgaa caaataattgctgacggaaaagttgatgaaagtgaaaaaacattagctaataattcactt aatacatacaacacaacattaactgcttattctaaaacaattcaagaagctctaaataca ttatcacaaatcatctcttctgatgtagcaagtaaaaaagttgaagaattcaatggtgta ataactacaatttcttcagacgttgatacaatcaagaaacaaagagatggtgcagtaatc acttattattatagcggtgtacctacattatctaacgatccagctaaaagttggacgact aatgatttaaaagacttacatattaaagatatgtatttagacactaaatctggttatgca tatactttcactaaatctg gtactagttattcttggaaaccacttactgaccaagttatt gttagctcattgaaacaagcaaaaaatgcacaagacacagcggacaataaacgtagagtt tttgtaactcaacctattcctccttatgatcaaggagatatgtggactcaaggttcacaa ggagatatttatgtctgtggaacttcgagagctactggctcattcgtaagtagcgactgg gttaaagcgagcaaatacactgacgatacagtagctaaacaggcagcaaaagatttagaa gattataaagtcaaaatgactaaagacttcaaagatttaaatgacggtgtatctactttt aaaactgaagtggttaaagatttcaaagatggaattgtaactgaagctgagaaaactaga ttacgtgttcaattagatatcttagatagagaaagtcaagatatcgaagaaagatataat agtatctttaacagtcaatatgcagatactcaagttaaaacttctatttctaacgcacgc tctacttataataactctcttactaagttaagaaacactattcaaaccgtgattgaagat ggaaaagtaacgcctactgagaaaactactgctaatcaaactttaaccgcatataataat gctttaacgagttattcagctgctatccaagaagcattaaatagcatgtcaaaagtaatt gctcaaaaagaagctactagtcaagtaaatcaattcaatgaagttatcaaaaatataaat acaaatattactgatattcaaaaacaagttgatggtgcaattgaaactttctattacagt ggagtaccaacacttactaatatccccgcttcgtattggacaactgctagtaaacgtgaa gctcatttaggtgatttatatttagacactgctactggtgttgcttatcgtttcttaaaa aaaggaacaacttcccctacttactattggtctccaatttctg atcaaattattacagac gcattgaatagagcaaaaacagctcaagacaccgccgatggaaaaagaagagtttttgta aatacacctgttccaccatacgacactggtgacatgtggacgcaaggagctagtggtgac atcttagtttgtaaaacacctaaagctaaaggtggtatttactcaataagcgactgggta aaagctagtaagtatacagatgatacagtagcaaacagtgctgttcaacaattaaatgaa tacaaacgcactaataatcttgatatcgcagacctaaagagaaaaactagtgacttcgaa aaaacagttgtaaatgcatttgacgatagagtcattagtatttccgagtcttcatctatt aaaggacaacttgctctacttaatcacgaaaaagatagattaactagacaatacgaaaat ataatcagaaattctaatcttgttggagcagaaaaaactaaattatctactgcatattca aatataaatactaagcttagtgatttaagtacaactattaatagtgcaattgttgataat aaaattgttgacgctgaaagtaaatctgtaacttcaaaatttgaattgtataaagcttca gttaatgaatatcaaatcgcttttgataatgctctaaactcaattattagagaaatcgct tcttcccaagctaaagatagattagatgaatggaaacgtacagaatttagtacagactca gacggtattattgaaagagtagctggtgctaagtttgactcaaaatggactgatacttgg agaaatacagttaacccagctattcaacaagtgagtaatataacatatggaagtgaaaac ctattacttaatagcgaaagtcgaagtgacggtgctaataccacgactcactcttttata agatactacctgacacgccctttagaaacagggaaaacttatactttaaaagctagtgtt ttaaca actgatgaaagacaaagtggacaaattagtgtttatccatactcccctaacgga gcaagagagacagtaaatattaaagacggtaaaattacttatacatttactgcacaaact gaaagtacacaatttcttatttataaagacgtggctggtcaatctgatgtagacttaaat gtaacaatcgagaaggctattttagtcgaaggaaataaagttacagggtggtctccagca ccagaggagacttcttctgctttacgagattataatactcgtatctcctcagcagaaaca ttcattgagaaaaacaaagaaaagatttctcaaattgctactaaatctgatgttgacgct tcacttagtaaagtagctacttatgaaactcaatataatgtttctagcggaactaactat caaattcctcttcaagaatacaatggttcattctttaccgacaactacacttatgaagtt gtagctaaaaataactctttaagttctaacaacgtagcaactgctatattcgtaagtaaa ggttcaaacaatggttatgaattggttgaattagacaacatgtctaaaactggtgctaac cctagatttgttttagacagtaaaggtagaccttctatctctactttctcccctcaatct actactcaagatatttcagttatttacactaaatatttaggtagtgcttcagcaatcaat acaactaaatcattgattgagcaaactgctagttctattgaattacaagttaagaaactt actgctgagactgaatacaacaacatattattaaattcagacttctcttctggctgggaa ggttggataaatgttgatcctcagtatagtattgttgataaaaatacttttggtatcact cttcctgacgcaatcactaataaaaataagaaatataatacagttaaaatgacatacaat aaaaatacaaattacccttctgtattttct aattttatttctgttggaaaaggtcaagag gtagctattggtgaacatttaacactaacttgttatgcctatatcccttcttcatctaaa ggtaaattaactggtaacatatatattgaattcgctggttactatgaaaaagaccaaaaa tcaaacccaatgattgctagacatgaaatattacctaaagattttgaatataataaatgg ttcagaatgacagctagtactgctattccttctactaactctgagggtaaaaaaatcaat tatattagagcttgtttacgttatgacggtaaaaatcaaagcgtaaataatagtgctata ttctattatgcgttacctcaattagagcgtggatcaaaaccaaccgagtggtcgttatca agacttgacgtatttagcactgaacaattggcagctaagattgccttaaacccagagagt gtggatattatcgcaagaaatattgatttcaatactgactcaatgaagatttataattct aacggtacattaaacatttctggagatactttaacaattagtaacaacaatagttctaat gaagtaattataaatccaaaaggttttacacttaaaaaagatggtgtagttaagtttaaa aatggactagacacaagcgattatagtgtccaagcttatgaaccacagtttagttcatgg aataatattaaagctactgatcccgctgctaagagtaagtataattacattcgacatatt gagccggggatgaatggttattacactataaatactggtgtttacaattttgcagtacaa cacaaacaactattagaggtaaataatacaaaaaatgcgagagttaacaggtatacatat ctttacaacaaaaggtatttaaaaatacaaatgtctgcttcttctcgaggtaaaagtaag ctttatataatattcaagacaaaaactggagatactacactccatcaagaaata gttagt tctagttcaatggtatacccagatataacaattgacttacaggctaaattaggttatccg cctaacaatttgccagacttttttgaattacaagctggtattgcctatggagaaaataat tctattgatggtttctttagaattagacgtatggcaatgacagatacaccaaatgcggag gtt 246. atgtataacgtgacacagcatgcgacttataaaacaaaaaataaacgagaaactgctgta ttaatcggtgtacatgctcaaacggatcgtcaatttaattttgaatctactatggaagag ctcgatgctttatcacaaacttgccaacttaatgttaaaggacaaatcactcaaaataga gagcaatttgaccataaatattatgttggaaaaggaaaaatcgatgaaataaaatctttc atagaattccatgatatagatgttgtcgtaaccaacgatgaattaacgacggcacagtct aaaacgttaaatgataatttgggcattaaaatcatcgatagaacccaattaattttagag atattcgcgttgcgagcgagaagtagagagggaaagctacaagtagaacttgcacaactc gattatttgttaccaagactacatggtcatggtaaaagcctgtctcgtcttggtggtggc ataggaacaagaggcccaggtgaaacaaaattagaaatggatcgtcgccatattagaaca cgtatgaatgagattaaacatcaattaaaaacggtcgtggatcatcgggaaagatataga aataaacgtgaacaaaatcaagtttttcaaatcgctttagttggttatacaaatgcagga aaatcgtcatggtttaatgttttagctaatgaggagacctatgaaaaaaatattttgttt gcaacattagatcccaaaacacgacaaatacaagtgaatgaaggatttaatttaattatt tctgatac ggtaggatttattcagaaattaccaacgacattggtggctgcgtttaaatct acactagaagaagctaaaggtgcagacgtacttatgcatgtcgtcgatgcaagtcattcg gaataccgtactcaaattgacactgtaaatcaaattattaatgatttagatatggaccat attccacaagtagttatttttaataaaaaagacttatgtaacgaacagatggatgtacct gtatctaaatctgcgcatgtttttgtatctagtcgtgatgaaaatgataaacaaaaggtg aaaaatttagtaattcaagaaataaaaaatagtctcagcccatacgaagaaattgtagat agtgctgatgcagatagattatattttcttaaacaacacacgcttgttactgaattaata tttgacgaaacacaagcatcttatcgtatcaaaggatttaaaaaatta 247. atgatgatcatcgtcatgttaatcttgagttatctgattggtgcattcccaagcgggtta attattggtaaattattttttaaaaaagatataagacaatacggtagtggaaatactgga gcaactaacagttttcgtgttcttggaagaccagctggatttatagttacgtttttagat attttcaagggatttattacagtcttttttccactatggttcccagttcatgcggatggt gttataagcaccttctttacaaatggtttaatagtaggattgtttgcaatactcggtcac gtgtatccaatatatctgaaatttaatggcggaaaagcagtagctaccagtgcaggagtt gtattaggtgtcaatcctattttacttcttatcttggcaattatcttttttagtgtatta aaaatctttaaatatgtttctttatcaagtatcattgcagcaattagttgtgtgattggt tcaatcatcattcatgattatattttacttgctgttagc ggaattgtttcaatcatatta ataattcgacacaaatctaatatagttagaatttttaaaggagaagaacctaaaattaaa tggatg 248. atgatgaatcatagtgaagctttaactgaacaagtattttcatttgcttcagagctttat gcttatggtgtaagagaagtagtaattagtccaggttcacgttcaacaccattagcactt gttttcgaagcacatccaaatattaaaacatggattcaccctgatgagcgaagtgctgca ttttttgctttaggtcttattaaaggtagcgaaaaacctgtagcaattctttgtacatct ggaacagccgctgcgaactacacacccgctatagctgaaagtcaaattagtcgtttgcct ctcgttgttttaacgagcgacagaccgcatgaactgcgcagtgtgggtgcacctcaagca atcaatcaggtaaatatgtttagtaattatgtgaactttcaatttgatttgccgattgct gatggaagtgaacatacaattgatacaattaattatcaaatgcaaattgcaagtcaatat ttatatggaccacaccgaggaccgattcattttaatttaccatttagagaaccactaaca ccagatttagatcgtgtcgatttattaacatctgtaactaaaacgttacctcattatcag aaatcgatttcggtagatgatataaaagacatattacaagaaaaaaatggtctcatcatt gtcggagatatgcaacaccaagctgttgatcaaatattaacgtattcaactatatatgat ctgccaatcttagcagatccccttagtcagcttcgtaaagagaaacatcctaatgttata accacttatgatttattgtatcgagcaggattaaatttagaagtagactatgtcatacgt gtaggtaagccagttatttctaaaaaattaaatcaatggttgaagaaaacc gatgcgtat caaattattgtgcagaataatgatcaaattgatgtatttccgacaccacctcatatatct tatgagatttcagcaaatgattttttccgttcattaatggaagaaccacttgttgaacga aaaaaatggttacagcaatggcaatcacttgaacaacaagcacgcattgaaataagtgat tacttaaagcatgcgacagatgaagcggcatatgtagggagtttaattcaaaaacttaca aaagaagatacattatttgttggaaatagtatgccaattagagatgtcgataatttactg tttgatagtgaggcatctgtatacgctaatcggggtgccaatggaatagacggagtagtt tcaactgcgctaggtatggcggcacataagaatgtgacattgcttattggtgatttatct ttttatcatgacatgaacggtttattaatggccaaattaaatgaacttcatattaacatt gtattagttaataacaacggaggaggtatcttttcatatttacctcaaaaacgatcggct acaaaatattttgagcgattatttggaacaccaacaggcttaaactttgaatatactgca ctgttatatgattttacatttaagcgctttgataatttgactgactttaaatatgctgaa ttatctaaaatgggttctcacatgtatgaagttataaccaatagagacgaaaatttgcat caacaccaaaatttatatcagaaattgagtgagattgttaatgttacatta 249. atggcgaaaaaattcaattacaaattaccgtctatggttgctttaacgttatttggcaca gcttttactgcacatcaagcaaatgctgctgaacaaccacagaatcagtctaatcataaa aatgtattagatgatcaaactgccctcaaacaagcagaaaaagctaaaagcgaagttaca caatcaactacaaatgta tctggtacacaaacatatcaagaccctacccaagttcaacct aaacaagacacacaaagtactacatatgatgcatcattagatgaaatgagtacttataat gaaatttcatcaaatcaaaagcaacaatctttatcaacagatgatgcgaatcaaaatcaa acgaattctgttacaaaaaatcaacaagaagaaacaaatgatttgacacaagaagataaa acatccactgatacaaatcaattacaggagacacaatctgtagcaaaagaaaatgagaaa gatttaggagctaacgcaaataatgaacaacaagacaagaagatgactgcaagtcaacct tccgaaaatcaagcaattgaaactcaaactgcttctaatgataatgaaagccaacaaaaa agtcagcaagtaacttctgaacaaaatgaaactgctacacctaaagtatcaaatacaaac gcatctggttataattttgattacgatgatgaagacgatgatagctcaacagaccattta gagcctatctcattaaacaatgtgaatgctacatctaaacaaactacttcatataaatat aaagaaccagctcaacgtgtaacaactaatactgtaaaaaaagaaacggcatctaatcaa gcgactatagatacaaagcaattcaccccatttagtgcaactgctcaaccgagaacagtt tattctgtatctagtcaaaaaacatcatcattaccgaaatatacaccaaaggttaattct tcaataaataactatattcgtaaaaagaatatgaaagcaccaagaattgaagaagattat acgtcatatttccctaaatatggctatagaaacggtgtgggacgtcctgaaggtatcgtt gttcatgatactgcaaatgataactcaacaatcgatggcgagattgctttcatgaaacgt aattacacaaatgcattcgtacacgcatttgttgatggcaat agaattatagaaacagct ccgacagattacttatcttggggtgcaggtccatatggaaatcaacgttttatcaatgtt gaaatcgtccatacacatgattatgattcatttgcacgttcaatgaacaactacgctgat tatgctgcaacgcaattgcaatattataatttaaaacctgatagcgctgaaaacgatgga agaggaacagtttggacacatgctgctatctctaacttcttaggaggtactgatcacgct gaccctcaccaatatttaagaagtcacaattatagctatgcagaattatatgacttaatt tatgaaaaatatttaattaaaacgaagcaagtagcaccttggggcacaacatctacaaaa ccgtcacaaccttctaaaccatcaggaggaactaataataagttaactgtgtctgctaat cgtggtgttgctcaaattaaaccaacaaataatggcttatatacaactgtttatgacagt aaaggtcataagactgatcaagtacaaaaaactctatccgttactaaaactgcaacatta ggaaataacaaattctatttagttgaagactacaatagcggtaaaaaatacggttgggtt aaacaaggtgatgttgtttataacactgctaaggcaccagtaaaagtgaatcaaacatat aatgttaaagcagggtcaacactttacacagttccttggggtacaccaaaacaagttgct agcaaagtatctggtactggaaatcaaacatttaaagcaactaaacagcaacaaattgat aaagcaacgtatctttatggtacagtgaatggtaaatctggttggattagtaaatattac ttaactacagcatctaaacctagcaatccaactaaaccttcaacaaacaaccaattaaca gtgactaacaatagtggtgttgctcaaatcaatgcaaaaaatagtggcttatatactaca gttta tgacactaaaggaaagacaacaaatcaaatccaacgtacattgtcagtgacgaaa gctgccacacttggtgataaaaaattctatcttgttggtgattataatactggtacaaat tatggttgggtaaaacaagatgaggtcatttacaacacagctaaatcacctgtaaaaatc aatcaaacatacaacgtcaaacctggtgttaaattacacacagtaccttggggcacatat aatcaagtggctggaacagtttcaggtaaaggcgatcaaacttttaaagcaactaaacaa caacaaattgataaagcaacatatctttatggtacagtgaacggtaaatctggttggatt agtaaatactatttaactgcaccatcaaaagttcaagctttgtctactcaatcaacacca gcacctaaacaagtaaaaccatctacacaaactgtaaatcaaattgctcaagtgaaagct aataattctggaataagagcatctgtatatgataaaacagccaaaagtggtacgaaatac gctaaccgtacattccttatcaataaacaacgtactcaaggtaataacacgtatgtacta cttcaagatggaacaagtaatactccattaggatgggtaaacattaatgatgtgacaact caaaatatcggaaaacaaactcagtctataggtaaatattcagtaaaacctacaaataat ggtctatattctattgcttggggtactaaaaaccaacaattactagcacctaatacgcta gctaatcaagcatttaatgcttccaaagctgtttacgttggtaaagatttatatctatac ggtacagtcaataacagaacaggatggattgctgctaaggatttaatccaaaacagtact gacgctcaatcaacaccatataactatacttttgttatcaataatagtaaaagttatttc tatatggatccaacaaaagcaaaccgata ttctttaaaaccatattatgaacaaactttc acagtcattaagcaaaaaaatattaatggcgttaaatggtactatggtcaacttttagac ggtaaatatgtttggataaaatcaactgacttagttaaggaaaaaattaaatatgcatat actggaatgactttaaataacgcgataaatatccaatctcgtcttaaatataaaccacaa gtacaaaatgagcctttgaaatggtcaaatgctaattatagtcaaattaaaaatgctatg gatacaaagcgtttagctaatgattcatccttaaaatatcaattcttacgtttagatcaa ccacaatacttgtcagcacaagctctcaataaattattaaaaggcaaaggtgtacttgaa aaccaaggcgctgcatttagccaagctgcacgtaagtatggtctaaatgaaatttatctt atctcacatgctttagtagaaacaggtaatggaacttcacaacttgctaaaggtggagat gtttcaaaaggtaaattcacaactaaaacaggtcacaaataccataatgtctttggaatt ggtgcatttgacaataatgcacttgtagatggtatcaaatacgctaaaaatgctggatgg acttctgtctctaaagcaattattggtggcgctaaattcattggaaattcatacgtgaaa gcaggacaaaatacgctatataaaatgcgttggaatcctgcaaaccctggtacgcatcaa tatgcaactgatattaattgggcaaatgtcaacgcacaagtattaaaacaattttatgat aaaattggtgaagtcggtaagtacttcgaaattccaacatacaaa 250. gtggcatttgaatttagattacccgatatcggggaaggtatccacgaaggtgaaattgtt aaatggtttattaaagccggcgatacaattgaagaagatgatgtattagcagaagttcaa aa tgataaatctgtagtagaaattccttctccagtaagtggtactgttgaagaagtgtta gtagatgaaggaacagtggcagtagtaggagatgtcatcgttaaaattgatgcacctgat gcagaagaaatgcaatttaaaggtcatggcgatgatgaggattctaagaaagaagaaaaa gaacaagaatcaccagtgcaagaagaagcttcatcaactcaatcacaagaaaagacagaa gtagatgaaagtaaaactgttaaagcgatgccgtcagtgcgtaagtatgcacgtgaaaat ggtgtcaatattaaagctgtaaatggttctggtaaaaatggacgaatcacaaaagaagac atcgatgcatacttaaatggtggtagttccgaagaaggttcaaacactagcgcagcatct gaatcaacttctagtgatgtcgttaatgcttctgcaacacaagcattaccagaaggcgac ttccctgaaactacagaaaaaatacctgcaatgcgcaaagcaattgctaaagcaatggtt aattctaaacacactgcacctcatgttacattaatggatgaaattgatgtgcaagaatta tgggatcaccgtaagaaatttaaagaaattgctgctgaacaaggtacaaaacttactttc ttaccatatgttgttaaagcattagtttctgcacttaaaaaatatccagcacttaatact tctttcaatgaagaagctggagaggttgtacacaaacattactggaatattggtattgct gcagatacggataaaggattattagtaccagtagttaaacatgccgatcgtaaatcaata ttcgaaatttctgatgaaattaatgaactagctgtaaaagcacgtgatggtaaattaact tcagaagaaatgaaaggtgcaacatgcacaattagtaatatcggttccgctggtggacaa tggttcactccagttatcaatcaccc agaagtagctatcttaggaattggccgtatcgct caaaaacctatcgttaaagatggagaaattgtagctgcaccagtgttagctttatcatta agctttgaccatagacaaatcgatggtgctactggacaaaatgctatgaatcacattaaa cgcttattaaataatccagaattattattaatggagggg 251. atgaatgaaacagacgaaatttcacaaatctataacaagcatcgattaccaagtttaagt ggtctagcaaaagtgtctccacttgttcatagggccagcataggaggcgttttaaatgtg gcagaattaaacagaattaaacgcctagttcaagtgcaaaatcaatttaaaacattttac aatcaaatgctagaagaagatgaagaggttaagtatcctatactgcatgataaaatgaat catctaccgatacttacagatttatttaaagaaattaatgaaacatgtgatgcacacgat ttatttgaccatgcaagttatactttacaaagtattagaagtaaaatttcaagaacaaac caacgaattcgtcaaaatttagatagaatagtgaaaaatcaagggaatcaaaaaaaacta tctgatgcaattgtaacagtaagaaatgatcgcaatgttattccggtgaaagctgaatat agacaagatttcaatggtattgttcatgatcaatcggcatcaggacaaacactatatatt gaaccgaattctgttgtagagatgaataatcaaatcagtcgtttgcgtaatgatgaagca gttgaacgtgaacgtatattgactgaattgacgggatttgtttcggcggaagctgacgca ttactcattgctgaatcggttatgggtcaaattgattttttaattgctaaagctcgttat gcgcgcactataaaagggacaaaacctacatttaaagaggatcgaactatatatttacct aatgc atttcaccctttattagacaaagatactgttgtagcaaatacaattgaatttatt gacgatgtagaaacagtcataattactggaccaaacacgggtggtaagacggttacttta aaaacactaggattgataattgtcatggcacaatcaggattgttaattcctacactggat ggaagtcaattaagtatctttgaaaatgtatattgtgatattggagatgaacaatctata gaacaatcattatcaacattttcatctcacatgaaaaatatagtagaaatattacaagat gcagatcaaaatagtctcattttatttgatgaactaggcgcaggtacagatccaagtgaa ggtgcggcactcgcaatgagtatcttagattatgtacgccgtttagggtctttagttatg gcaacaacacattaccctgaattaaaagcttatagttataatcgtgaaggtgtcatgaat gcaagcgttgaatttgacgttgaaacactgagcccgacttataaattattaatgggtgtt ccagggagatctaatgcctttgatatatcgaaaaaacttggtctaagtctcaacatcatt aataaagctaagacaatgatagggacagacgagcaagagatcaatgccatgattgaatca ttagaacaaaattcaaaacgtgttgatcaacaacgtatagaattagatcgacttgtgagg gaagcacagcaaacccacgatgctttgtctaaacaataccaacagtatcaaaattatgag acatcattgatggatgaagctaaagaaaaagctaatcagcgtgtgaaatctgcgactaaa gaagcggacgaaattcttaaagaacttagaaatctaagagatcataagggcgctgaggta aaagaacatgaattaattgataaaaagaaacaacttgatgatcaatatgaggtaaaatca attaagcaacatgttcaaaagaaaaagta tgatacgattcatactggagatgaagtgaaa gttctatcttacggtcaaaaaggtgaagtgcttgaacttgtaggtgacgaagaagcagtt gtacaaatgggaatcattaaaatgaaattacctattgaagatttagaaaaaacgaaaaag aaaaaagaaaaacctacaaaaatggtaacaagacaaaatagacaaactattaaaacagaa ctagatttaagaggatatcgttacgaagaagctttaaatgaattagatcaatatcttgat caggcggttttaagcaattacgaacaagtttatattattcatggtaaaggtacgggggca cttcaaaaaggtgttcaacaacatttgaaaaaacataaaagcgttagacaatttagggga ggtatgcctagtgaaggtggatttggtgtcactgtggcagaactcaag 252. atgagtttttttaaacgtctgaaagataaattttctagtaaaaatgaagatgatattcaa aaagacctggatgaatctgtagattcaaatgttaacagtgattcagattcaatggatccg aatgattctgatgaacaagttaaacccaaaaagaaacctaaaaaattaagtgaagctgat tttgacgaagatggcttgatatcgattgaagattttgaagaaatagaagctcaaaaaatt ggagcaaaattcaaggccggtttggaaaaatcacgtcaaaacttccaagaacagttaaat aatttaattgctcgatatagaaaagttgacgaagatttcttcgaagctctggaagaaatg cttattactgcggacgttggttttaatactgttatgaaattaactgatgagctacgtaca gaagcacaaagacgtaatatacaagaaacagaagacttaagagaggttatagttgagaag attgtagaaatctatcatcaagaggacgatcattctgaagcaatgaatattgaagatgga cgtttaaatgtcatactgatggttggtgtgaatggtgtcggcaaaacaacaacaattggt aaattagcttatcgttatcaacaagaaggtaaaaaagtaatgttagctgctggtgatact tttagagctggagcaattcaacaattaaacgtctggggagaacgtgttggcgttgaagtt gtgagtcaaaacgaaggttctgaccctgcagcagtagtatatgatgcgattaatgcagca aaaaataaagacgtagatattttaatttgtgacactgcaggacgcttgcaaaataaatct aatttaatgcaagagttagataaaatgaaacgtgtgattaatcgagcaatacctgatgcc ccccatgaagctttattatgcttagatgcaacaactggtcaaaatgcactttcacaagca cgttcatttaaggaagttacaaatgtctcaggtatagttttaactaaattagacggtact gctaaagggggtattgtattagcaattcgaaatgagttacacattccagttaaatatgtt ggtttaggtgaaaaaatggatgacttacaaccgtttagtcctgaaagctatgtatatgga ttatttgctgatatgatagaacaaaatgaagatattcctgaagaaatctctagaaattca tccgttgaatctgaagaaggtaac 253. atgaaaagaaattggtggaaagaagcagttgcatatcaagtatatccacgaagttttaat gatagtaatggagatggaataggtgatctacctggattaattgaaaaattagattatcta gaaaatttaggaatagatgtcatttggttaagcccaatgtatccatcaccaaacgatgat aatggatatgatattagtgactacaaaggcattatgagtgaatttggtacaatgaacgat tttgatcaattgttatcaagcatacatcaaagagggatgaaattaatattagac ttagtg gttaatcacacatcagatgaacacccttggtttattgaatcaaaatctagtaaaacaaat gcaaaaagagattggtatatttgggcagatcctaaaccggatggatctgaacctaataac tgggaaagtatctttaatggttcaacttgggagtttgacgaatcgactaagcaatactat ttccatttatttagcaaaaagcagccagatttaaattgggaaaatccagatgtaagacaa gctgtgtttgaaatgatgaattggtggtttgaaaaaggtattgacggatttagagttgat gccattactcatattaaaaagaattttgaagcaggagatttacctgtacctgatggcaaa aaatttgctccagcatttgatgtagatatgaatcagccaggaatacaagaatggctccaa gaaatgaaagataaatcgttaagtcggtatgacattatgactgtaggcgaggctaatggt gttactcctaatgatgctgaagaatgggtaggagaagaaaatgggaaatttaatatgata ttccagtttgaacatcttggtttatggagtactggcgatacgaaattcgatgttaaatcc tataaacaagtcttaaatcgttggcaaaagcaactagaaaatgtaggttggaatgcttta tttatcgaaaaccatgatcaaccacgtcgtgtttcaacctggggtgatgataaaaattat tggtatgaatcagcaactagtcacgctactgcctactttttacaacagggcacacctttt atttaccaaggtcaagaaataggtatgactaattatccatttgaaagcattgaaagtttc aacgatgtcgcagtgaaaactgaatatcaaatagtcaaaaaagaaggtggagatgtcaat caattactagataaatataaaatggaaaaccgagacaatgcaaggactccaatgcaatgg aataattctatcaatgc tggattcactactggtaagccatggtttcatgtaaaccctaac tatacagaaattaatgttaaacaacaactaaatgataagttttcgatactttcttattat aaagcgttaattcaactaaaaaaatctgatttgatttacacctacggtaagtttaatatg gtcgatgctgaaaataagcaggtttttgcatatacacgcacatttaaaaacaatactgta ttaattgtagccaatctcacaaatgaagtatcagaactaaacctaccttttgaattagat atttcatctgtagatataaaattgcataattatcacttaaatgatataaatttagaccat attaaaccttatgaatcattcgtcgttgaaata 254. ttgagtcatagaaagctatttccttctatattccatttatatcaacaagacaatttagat gaacatattgctattattggtataggacgtcgcgattataataacgaacaatttcgcgac caagttaaagcgtcaattcaaacttatgttaaagatacagatagaattgatgagtttatg acgcatgttttttatcataaaactgacgtgagtgataaagaaagttatcagtcattactt caatttagtgagcgactagattcagaatttgctttaggtgggaatcgtctgttttactta gcgatggcaccacaattttttggagtgatctcagattaccttaaatcttctggtcttact caaactacaggatttaaacgcttagttatagagaaaccatttggcagtgatcttaaatct gctgaatcattaaataatcaaataagacgttcgtttaaagaagaagaaatttatcggata gatcactatcttggcaaagatatggtgcaaaatatagaagttttgcgattcgcaaacgcg atgtttgaacctttatggaataataaatacatttcaaatattcaagttacatcatcagaa gt attaggtgtcgaagatcgtggtggctactatgaatctagtggtgcacttaaagacatg gtacaaaatcacatgctacagatggttgctttacttgcaatggaagcaccgataagtttg aatagtgaagatatacgtgcagaaaaagtcaaagtacttaaatctcttagacaattaaaa ccagaagaagttaaaaagaatttcgtgcgtggtcaatatgatcaaggcaatatagatggt aaacaggttaagtcatatcgagaagaagatcgcgtagcaaaggattcggttacaccgaca tttgtatcgggtaaattaacaattgataactttagatgggctggagttcctttctacatt agaacgggtaaacgtatgaaatcaaaaacgatacaagtcgtagtagaatttaaagaagta cctatgaatttatattatgaaactgacaatttactagattctaatttgctagtcattaat attcaaccaaatgaaggaatttcattgcatttaaatgctaaaaagaacattcaaggaatt gatactgagccagtgcaattatcatacgcaatgagtgctcaagataaaatgaatacagtt gatgcatatgaaaacttattgtttgattgtcttaaaggtgatgcgactaattttacacat tgggaagaattaaaatctacttggaaatttgtagatgcaatccaagatcaatggacaatg gttgaaccatgtttccctaactatgaagcgggtacgaatggacctcttgaaagtgatctt ttattaagtcgtgatggaaatcattggtgggatgatatccac 255. atgattaaaaaaaacaaagaagaactgaatgacatggagtatctagtcactcaagaaaat ggtactgaacctccgtttcaaaacgagtattggaatcactttgaaaaaggaatttacgtt gataaattgtccggcaaaccattatttacttcagaggat aaatttgaatctaattgcggt tggccaagtttctccaaagcattaaatgatgatgaaatcgtagaacttgttgataaatca tttggtatgattagaactgaagttcgatcagaaaaagcaaatagtcacttggggcatgtt tttaatgacggacctaaagaaaaaggtggtttaagatactgtattaactctgctgcgatt cagtttataccttatgataaactagaagagttaggatatggagatttaattaaacatttt aaaaaat 256. ttgaaaaagttagcctttgcaattacagccgcttcaggcgcagcagcagttctatcacat catgatgctgaagcttctacacaacataaggttcaatctggagaatccttatggactatt gcacaacaatacaatacttcagtagaaagcattaagcagaataataatcttagcaacaat atggtattcccaggacaagttattaatgtaggtggaagtgcttcacaaaatactagttca aacacttcttcaagttcagcatcttcacatactgtagtagcaggtgaatcattaaacatc atagctaataaatatggtgtttcagttgatgcattaatgcaagcaaatcatctaaatggt tatttaattatgcctaaccaaatattaactatccctaatggtggttctggttcaggatca ggtggtacagcaactcaaactagcggtaattatacttcaccttcattcaaccatcaaaac ttatacactgaaggtcaatgcacatggtatgtgttcgacaaacgttcacaagctggtaaa cctatcagtacttactggtctgatgcaaaatactgggcgtcaaatgcagcgaatgatggt tatcaagttgataatactccatctgttggtgcaattatgcaaagtacacctggaccatat ggtcatgtagcatacgttgaacgtattaatggtgatggtagtattttaat ttcagaaatg aattatgcaaatggtccatacaatatgaactatcgtactatcccagcttcagaagtatct tcatatgcatttatccactaa 257. atggcacgtattgctacaaaattgggctatcctgaaagcaatagtttcgtgactaatact gtaattgaatttgttttacataacgaagcatatcctcggttatataggattaaaactcga gatacgaacttaataaaaatttctcaagctaatgaaatctcacgtcaaattacaaatggc acgatgacgcttgaagaagctaagtatcaattagaggaaatatatgttgctaaaagagat agcagtctacccttcaaaggaattgccgcagcaattatcgctacgagcttcctctatcta cagggaggtcgtctggttgatatcatcacagctgtattagctggaacgattggatactta gtagtagaaatattagatcgaaagctacacgcacaatttattccagaatttataggttct ttggtaataggtattatttctgtaattggacatgcatttgttcctagcggagatttagct acaattatcattgccgcggtcatgcctattgtacctggagtacttattacaaatgctatt caagatttattcggaggacatatgttaatgtttacaacaaaatctttagaagctttagtt actgcctttggtataggcgctggtgtaagttcaatattaattttagtc 258. atgacagaatttgacttatccactagagagggtcgttggaaacatttcggttctgttgac cctgtcaaaggtacgaaaccaactactaaaaatgaaatgaccgatttacaaagcactcac aaaaatttcttatttgaaatagaggaagtaggcattaaaaatttaacttatccagtttta attgatcagtatcaaacagctggtttatttagtttttcaacgagtttaaataaa aatgaa aaaggcattaatatgagtcgcatattagaaagcgttgaaaaacattatgataatggcatt gaacttgaatttaacacactacatcaattgttgcgtacgctacaagataagatgaatcaa aatgctgcaggtgttgatgtgtcaggtaaatggttctttgatcgttatagtcctgttaca catattaaagctgtaggtcatgcagatgttacttatggtttagctattgaaaatcatacc gttacacgtaaagaattaactattcaagccaaagtaacaacactatgtccttgctcaaaa gaaattagtgaatattctgcacataatcaacgtggtatcgttacagttaaagcatattta gataaaaataatgacgtcatcgatgattataaaaataaaattttagacgctatggaagcc aacgctagttctatcttatatccaatcttaaaacgtcctgatgaaaaacgagtaacagaa cgtgcttatgaaaacccacgatttgttgaagatttaattcgactaattgcagcagactta gttgaatttgattggattgaagggttcgatattgaatgtcgtaatgaagagtctatccac cagcatgatgctttcgcacgtctgaaatatcgcaaa 259. gtgcaaaaaaaatatattactgccattattggaacaactgcccttagcgcattggcatca actcatgcacaagctgcaacaacgcatacagtaaaaagtggagaatctgtatggtcaatt tctcacaaatatgggattagtattgctaaattaaaatcacttaatggattgacttccaat ttaatattccctaatcaagtattgaaagtatcaggctcatcttcaagagcaacgtcaaca aatagtggcacagtttatacagttaaagctggagattcattatcttctattgctgcaaaa tacggtacaacttatcaaaaaatcatgcaacttaat gggttaaataactatcttattttc cctggacaaaagttgaaagtttctggtaaagcgacgagttccagtcgtgcaaaagctagt gggtctagtggtcgtactgcaacatatactgttaagtatggagactcactatctgcaatt gctagtaaatatgggacaacgtatcaaaaaattatgcaattaaatggattaactaatttc tttatctatcctggacagaagttaaaagtgcctggaggtagttctagtagctcatcttct aataatactagatcaaacggtggctattattcaccaacttttaaccatcaaaacttgtat acttggggacaatgcacatggcacgtatttaatagacgtgctgaaataggaaaaggtatc agtacatactggtggaatgcaaataattgggacaatgcatcagctgctgatggatatact attgattatcgtcctacagtaggctcaattgcacaaactgacgctggttactatggtcac gtagcgtttgtagagcgcgtgaatagcgatggaagtattttagtttcagaaatgaactgg agtgcagctcctggaaatatgacatatagaacaattccagcttatcaagtgagaaattac aaatttattcatt 260. gtgaccaaaaaagcttttatttcttattctagaacaagtgatgaacatttaaatagagtt gtgagaataggagaaagtttgagagttgatcatggaattgatgttattttagatgtatgg gattgcactgagggagatgacttgaatttttttatggagtctatggttaatgacgagacg atagattttgttattatattaagcgattttcagtattttaatagagctaatgatagagaa ggaggagttggaaaagaaagcacaataattacttctcaaatttatgataagcaaaaagat agtaagtttatacctgtctttttagatattctggataatgg aaaaccatcattaccaact ttttgtaatactagattcgctattgatatgacagacatcgaattagatatagagaaaata gaagagattgcaagaaaaatacacgataaacctttattcgaaaaaccaagacttggtaaa gtaccagattataaccaaaatcaaaatgagttaaagaaagcaataaaaaaattaacttta tctaaaagttataatgaaacgagaaattttgaagaagctttagacattatttataaaact ttagaaaatatagaaaatagcgtagaggaatataataaagatgatttaatgactttaaaa gaggtttttgatacttggaaagaatttattacgtatgcgctaaacaatgataacttttat tttagggaattaatcatagagcattataataggtgcttaaagcttacggaagaagaattt gaaaatccaatgactaggatttttaattatttttcatttcttatactagtaagtgaatct ttatcttcaggagcaaatgaatttttgaaagatttattgaatgctaaatttcattttagt agaagagaagcaaattattatatattaagtttatatccccaggtgttatccaagaaatat tcatataatactaatgtcaaaaaaatgttagccgaaatgtactttgaagggaaggagtta aaaaaggttcaagatgcagatgtaattttatatacagaaagtcttatgaaaaaagatatt catagtgtatatgaaacgtggcatggggttctgttgtatagtagatggcctatgcttgag caacaaactattaatattttaataaataaatttcgtagtaaaaaatatctagatcaattt gactttttatttggaagttcacaaagagaagtatttgaaaactatgataagattaaatcc acacaagaaatacctactatttttaattttattgataaagaagaaattggcagctat 261. at gcactatctaaagaaagtaactatatacataagtttattaattttggtgagtggttgt ggagacagcaaagaaacggaaatcaaacaaaactttaataaaatgttaaatgtgtatcca actaaaaatctagaagacttttatgataaagagggttatcgtgatgaagagtttgataag gatgacaaaggaacatggattattagatctgaaatgacaaaacagccaaaaggtaagatt atgacttcaaaaggtatggtgttacatatgaatagaaatactagaagtacaactggttat tacgttattaggaaaatttctgaagataataaaagtgaaattgatgatgaagaaaagaaa tatcctataaagatggtaaataacaagataattccaactcaaaaaattaatgacaataaa ttgaagaatgaaatagaaaactttaagttctttgtacaatacggaagctttaaaaattca gatgattataaagaaggggatattgaatacaatcctaatgcaccaaattattctgcacaa tatcatttaagtaatgatgactataatattaaacaattaagaaaaagatatgatattaaa acgaaaaaaactcctagattattaatgagaggcgctggagatccaaaaggatcttctgta ggttataaaaatcttgaatttacatttgttaagaataatgaggaaaatatttattttacc gatagtattaattttaatccaagcaagggtaaatcattg 262. gtgaaacattcgaaaaagttacttttatgcatcagttttttattaataacgttttttatt ggtggatgtggatttatgaataaagacgatggtaaagaaacggaaatcaaacaaaacttt aataaaatgttaaacgtgtatcccactaaaaatctagaaaacttttatgataaagagggc tatcgagatgaagagtttgataaggatgacaaaggaacatgg atagttcattctaaaatg gttattgaaccaaaaggcaaaaacatggaatctagagggatggttctctttatcaatcgc aatactagaacatcaaaaggctattttatagtcaatgaaatagaaaaggatagaaaagga agacccattaataataaaaagaaatatcctgtaaaaatgaaaaataataaaattattcca accaaaccaatatctaatgataaattaaaaaaagaaattgaaaactttaaattttttgta caatatggcaattttaaagatattaaaaattataaagatggtgacatttcatacaatcct aatgtacctagttattctgcaaaatatcaattgagtaataatgaatataacgtacaacaa ttaagaaaaagatatgacatcccaactaaaaaagtacctaaactattgttgaaaggtgat ggggatttaaaaggttcatccgtaggttctaaaaatctagaatttacttttatagaaaat aaagaagagaatatctattttacagattctgtactatttagccctagcgaggataatgaa tca 263. atgcgttatctcaagaaagtaacgatatacataagtttattaattttggtaagtggttgt ggaaacggtaaagaaacggaaatcaaacaaaactttaataaaatgttagacatgtatccg actaaaaatctagaagacttttatgataaagaaggctatcgagatgaagagtttgataaa aaggataaagggacatggatagttggatctaccatgacaattgaaccaaaaggcaagtac atggaatctagaggtatgtttctatatattaatcgcaatactagaacaactaaaggttat tattatgtgaggaaaacaacagatgacagtaaaggtagactaaaagatgatgaaaagaga tatcctgtaaaaatggaacacaataaaattattccaacgaagccaatacctaatgac aaa ctaaaaaaagaaatagaaaacttcaaattttttgtacaatatggagattttaaaaactta aaggattataaagatggtgacatttcatacaatcctaatgtacctagttattctgcaaaa tatcaattgagtaataatgactataatgtaaaacaattacgaaaaagatatgatattccc accaaccaagcccctaaattattgttaaaaggagatggtgacttaaaaggctcatctata ggttccaaaagtttagaatttacttttatagaaaataaagaagagaatatctttttttca gatggtgtacaatttactcctagcgaggatagtgagtca 264. atgaaacattcaagcaaaataatagtatttgtaagtttcttaattttaacgatttttatt ggaggatgtggttttataaataaagaagatagcaaagaagctgaaatcaaacaaaacttt aataaaacgttaagtatgtatccaactaaaaatctagaagacttttatgataaagagggc tatcgtgatgaagagtttgacaaagatgacaaagggacatggattattaattctaaaatg attgttgaaccgaaaggggaagagatggaagcaagagggatggttttacgtataaataga aatacgagaacagctaaaggtaactttattataaaacgaataacagaaaataataaagga atacctgatgttaaagacaaaaaatatccagtaaaaatggaacacaataaaattattcca acaaaacaaattaaagataaaaaattaaaaaaagaaattgagaacttcaaattttttgta caatatggaaattttaaaaacttaaaggattataaagacggagagatatcttacaatcct aatgtgccaagttactcagcgcaatatcaattgaacaattatgataataatgttaaacaa ctaagaaaaagatatgatattcccacgaatcaagct cctaaattattattgaaaggtaca ggagatttaaaaggatcctctgtaggttataaacatcttgaatttacttttgtagaaaat aaaaaggaaaatatttattttactgacagtataaactttaacccgagtagggggaat 265. atgcgttatctcaagaaagtaactatatacataagtttattaattttaacgatttttatt ggaggatgtggttttataaataaagaagatagcaaagaaacggaaatcaaacaaaacttt aataagatgttaaacgtgtatcctactaaaaatctagaagacttttatgataaagaaggt tttcgagatgaagaatttgataaaggagataaaggaacttggattattaggtctgaaatg acaaaacagccaaaaggtaaaattatgacctcaagaggtatggttctctatatcaatcgt aacactagaacagccaaagggtattttttaatagatgagataaaagatgataatagtggt agaccgatagagaatgaaaagaaataccctgtaaaaatgaaccataataagatctttcca acaaagccaatatctgatgataaattaaaaaaagaaattgaaaacttcaaattttttgta caatatggagattttaaaaacttaaaggattataaagacggagagatatcttacaatcct aacgttcctagttactcagcgcaatatcaattgaacaataatgataataatgttaaacaa ttaagaaaaagatatgatattccaaccaatcaagcccctaaattattgttaaaaggggat ggcgacttaaaaggatcatctgtaggttctaaaaatttagaatttacttttgtagaaaat aaagaagagaatatattttttacagatgcagtacaattcactcctagcgaggatgatgaa tca 266. atgaagacctataagccgtaccgacatcaattaaggcgttcgctatttg cctcaacgatt ttcccagtatttatggtgatgattattggtttaataagcttttatgctatttatatatgg gtcgaacatcgcaccattcatcagcatacctatcaaactcaaaccgaattacaacgtatc gacaaacattttcatacgtttgttacgcagcaacaaaaacaatggcgtcatgttgattta tcacatccaactgatatcacaaagatgaaacgccaactattaaaacaagtccatcaacaa cctgcgatattgtattacgatttaaaaggttcttcacaatctttcacaaacaattatgaa caattagacacaacaaagatgtatttaatatcaaaatatcgaattgattttaaagacgat acttatatccttaaaatatatatgtcaagcacaccactacttaaaaacattaagaaaaat agtggacaatctgcactcattgttgattcatatgatactgttttatatacaaatgacgac cgattctctatcggtcaaaaatatcaaccaccacagtttgggtttatgaacgagtcttta aaactcaattctcatcatgcgcatcttattatatataaagatattcatgaaaccattgaa gatggaattgcattactagttgtcatgggtgttgttcttattctgcttgttatttttgga tatataagcgctgatagaatggcaaagcgccaatctgaagatattgaagcgattgtccga aaaattgatgatgctaaaaatcgacatcttggtagttacgaaccgttaaaaaaacatagt gagttagaggaaataaataattatatctatgacttgtttgaatcaaatgagcaattaata caatctattgaacagaccgaacgtcgtttacgtgatatacaattaaaagaaattgagcga caatttcaaccccatttcttattcaatacgatgcaaacgatacaatatttaattcctctt tcacccaaagta gcacaaacagtcatacaacaactatcacaaatgctacgttattctcta cgcacagcatcgcacacagtcaaattagcagaagaattaagctacattcagcagtatgtt gctatacaaaatatccgcttcgatgatatgatacagctttacatcgatgctcctgaagat gtacaacatcaaacaattggtaagatgatgcttcaaccactcgtagaaaatgccatcaag catggtcgtggtagtgaacctttaaagataacaattcgtatcagacttacgaagcgcaaa ttacatattctggttcatgataatggcatcggtatgtctccatcacatttagaacgcgtg cgccaatcacttcatcacgatgtttttgatacgacacacctaggtttaaatcatttacat aatagagccatcattcaatatggaacatatgcacgtctgcacattttctcaagaagccat caagggacattaatgtgttaccaaataccacttgtc 267. gtggatgatgtgacaaaatatggtccagttgatggagatccgattacgtcaacggaagaa attccgtttgataaaaaacgcgaatttgatccaaacttagcgccaggtacagagaaagtc gttcaaaaaggtgaaccaggaacaaaaacaattacaacaccaacaactaagaacccatta acaggagaaaaagttggcgaaggtgaaccaacagaaaaaataacaaaacaaccagtggat gagatcgttcattatggtggcgaagaaatcaagacaggccataaggatgaatttgatccg aacgcaccgaaaggtagtcaaacaacgcaaccaggtaagccaggagttaaaaatcctgat acaggcgaagtagtcacaccaccagtggatgatgtgacaaaatatggtccagttgatgga gatccgattacgtcaacggaagaaattccgtttgataaaaaacgcgaatttgatc caaac ttagcgccaggtacagagaaagtcgttcaaaaaggtgaaccaggaacaaaaacaattaca acgccaacaactaagaacccattaacaggggaaaaagttggtgaaggtgaaccaacagaa aaaataacaaaacaaccagtggatgagatcgttcattatggtggcgaagaaatcaagcca ggccataaggatgaatttgatccaaacgcaccgaaaggtagccaagaggacgttccaggt aaaccaggagttaaaaatcctgatacaggcgaagtagtcacaccaccagtggatgatgtg acaaaatatggtccagttgatggagatycgattacgtcaacggaagaaattccgtttgat aaaaaacgcgaatttgatccaaacttagcgccaggtacagagaaagtcgttcaaaaaggt gaaccaggaacaaaaacaattacaacaccaacaactaagaacccattaacaggggaaaaa gttggcgaaggtgaaccaacagaaaaaataacaaaacaaccagtagatgaaatcacagaa tatggtggcgaagaaatcaagccaggccataaggatgaatttgatccgaacgcaccgaaa ggtagccaagaggacgttccaggtaaaccaggagttaaaaatcctgatacaggcgaagta gtcacaccaccagtggatgatgtgacaaaatatggtccagttgatggagatccgattacg tcaacggaagaaattccgtttgataaaaaacgcgaatttgatccaaacttagcgccaggt acagagaaagtcgttcaaaaaggtgaaccaggaacaaaaacaattacaacaccaacaact aagaacccattaacaggagaaaaagttggcgaaggtgaaccaacagaaaaaataacaaaa caaccagtggatgagatcgttcattatggtggcgaagaaatcaagacaggccataaggat gaatttgatccgaacgca ccgaaaggtagtcaaacaacgcaaccaggtaagccaggagtt aaaaatcctgatacaggcgaagtagtcacaccaccagtggatgatgtgacaaaatatggt ccagttgatggagatccgattacgtcaacggaagaaattccgtttgataaaaaacgcgaa tttgatccaaacttagcgccaggtacagagaaagtcgttcaaaaaggtgaaccaggaaca aaaacaattacaacgccaacaactaagaacccattaacaggggaaaaagttggtgaaggt gaaccaacagaaaaaataacaaaacaaccagtggatgagatcgttcattatggtggcgaa gaaatcaagccaggccataaggatgaatttgatccaaacgcaccgaaaggtagccaagag gacgttccaggtaaaccaggagttaaaaatcctgatacaggcgaagtagtcacaccacca gtggatgatgtgacaaaatatggtccagttgatggagattcgattacgtcaacggaagaa attccgtttgataaaaaacgcgaatttgatccaaacttagcgccaggtacagagaaagtc gttcaaaaaggtgaaccaggaacaaaaacaattacaacgccaacaactaagaacccatta acaggagaaaaagttggcgaaggtgaaccaacagaaaaaataacaaaacaaccagtggat gagattgttcattatggtggtgaacaaataccacaaggtcataaagatgaatttgatcca aatgcacctgtagatagtaaaactgaagttccaggtaaaccaggagttaaaaatcctgat acaggtgaagttgttaccccaccagtggatgatgtgacaaaatatggtccagttgatgga gattcgattacgtcaacggaagaaattccgtttgataaaaaacgcgaatttgatccaaac ttagcgccaggtacagagaaagtcgttcaaaaaggtgaacca ggaacaaaaacaattaca acgccaacaactaagaacccattaacaggagaaaaagttggcgaaggtaaatcaacagaa aaagtcactaaacaacctgttgacgaaattgttgagtatggtccaacaaaagcagaacca ggtaaaccagcggaaccaggtaaaccagcggaaccaggtaaaccagcggaaccaggtacg ccagcagaaccaggtaaaccagcggaaccaggtacgccagcagaaccaggtaaaccagcg gaaccaggtaaaccagcggaaccaggtaaaccagcggaaccaggtaaaccagcggaacca ggtacgccagcagaaccaggtacgccagcagaaccaggtaaaccagcggaaccaggtacg ccagcagaaccaggtaaaccagcggaaccaggtacgccagcagaaccaggtaaaccagcg gaatcaggtaaaccagtggaaccaggtacgccagcacaatcaggtgcaccagaacaacca aatagatcaatgcattcaacagataataaaaatcaattacctgatacaggtgaaaatcgt caagctaatgagggaactttagtcggatctctattagcaattgtcggatcattgttcata tttggtcgtcgtaaaaaaggtaatgaaaaat 268. mtkkekdykksleqqktrvkiyksgkswvkasineiellktmglpflskneiqenvtekt kghklkksaakttalvggaftfnmlnnhqafaasetpitseissnsetvanqnsttikns qketvnstslesnhsnstnkqmssevtntaqssekagisqqssetsnqssklntyastdh vesttinndntaqqdqnkssnvtskstqsntssseknissnltqsietkatdslatsear tstnqisnltststsnqssptsfanlrtfsrftvlntmaaptttsttttssltsnsvvvn kdnfnehmnlsgsatydpktgiatltpda 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ssratstnsgtvytvkagdslssiaakygttyqkimqlnglnnylif pgqklkvsgkatsssrakasgssgrtatytvkygdslsaiaskygttyqkimqlngltnf fiypgqklkvpggsssssssnntrsnggyysptfnhqnlytwgqctwhvfnrraeigkgi stywwnannwdnasaadgytidyrptvgsiaqtdagyyghvafvervnsdgsilvsemnw saapgnmtyrtipayqvrnykfih 289. vtkkafisysrtsdehlnrvvrigeslrvdhgidvildvwdctegddlnffmesmvndet idfviilsdfqyfnrandreggvgkestiitsqiydkqkdskfipvfldildngkpslpt fcntrfaidmtdieldiekieeiarkihdkplfekprlgkvpdynqnqnelkkaikkltl sksynetrnfeealdiiyktleniensveeynkddlmtlkevfdtwkefityalnndnfy freliiehynrclklteeefenpmtrifnyfsflilvseslssganeflkdllnakfhfs rreanyyilslypqvlskkysyntnvkkmlaemyfegkelkkvqdadvilyteslmkkdi hsvyetwhgvllysrwpmleqqtinilinkfrskkyldqfdflfgssqrevfenydkiks tqeiptifnfidkeeigsy 290. mhylkkvtiyisllilvsgcgdsketeikqnfnkmlnvyptknledfydkegyrdeefdk ddkgtwiirsemtkqpkgkimtskgmvlhmnrntrsttgyyvirkisednkseiddeekk ypikmvnnkiiptqkindnklkneienfkffvqygsfknsddykegdieynpnapnysaq yhlsnddynikqlrkrydiktkktprllmrgagdpkgssvgyknleftfvknneeniyft dsinfnpskgksl 291. vkhskklllcisfllitffiggcg fmnkddgketeikqnfnkmlnvyptknlenfydkeg yrdeefdkddkgtwivhskmviepkgknmesrgmvlfinrntrtskgyfivneiekdrkg rpinnkkkypvkmknnkiiptkpisndklkkeienfkffvqygnfkdiknykdgdisynp nvpsysakyqlsnneynvqqlrkrydiptkkvpklllkgdgdlkgssvgsknleftfien keeniyftdsvlfspsednes 292. mrylkkvtiyisllilvsgcgngketeikqnfnkmldmyptknledfydkegyrdeefdk kdkgtwivgstmtiepkgkymesrgmflyinrntrttkgyyyvrkttddskgrlkddekr ypvkmehnkiiptkpipndklkkeienfkffvqygdfknlkdykdgdisynpnvpsysak yqlsnndynvkqlrkrydiptnqapklllkgdgdlkgssigsksleftfienkeeniffs dgvqftpsedses 293. mkhsskiivfvsfliltifiggcgfinkedskeaeikqnfnktlsmyptknledfydkeg yrdeefdkddkgtwiinskmivepkgeemeargmvlrinrntrtakgnfiikritennkg ipdvkdkkypvkmehnkiiptkqikdkklkkeienfkffvqygnfknlkdykdgeisynp nvpsysaqyqlnnydnnvkqlrkrydiptnqapklllkgtgdlkgssvgykhleftfven kkeniyftdsinfnpsrgn 294. mrylkkvtiyislliltifiggcgfinkedsketeikqnfnkmlnvyptknledfydkeg frdeefdkgdkgtwiirsemtkqpkgkimtsrgmvlyinrntrtakgyflideikddnsg rpienekkypvkmnhnkifptkpisddklkkeienfkffvqygdfknlkdykdgeisynp nvpsysaqyqlnnndnnvkqlrkrydiptnqapklllk gdgdlkgssvgsknleftfven keenifftdavqftpseddes 295. mktykpyrhqlrrslfastifpvfmvmiiglisfyaiyiwvehrtihqhtyqtqtelqri dkhfhtfvtqqqkqwrhvdlshptditkmkrqllkqvhqqpailyydlkgssqsftnnye qldttkmyliskyridfkddtyilkiymsstpllknikknsgqsalivdsydtvlytndd rfsigqkyqppqfgfmneslklnshhahliiykdihetiedgiallvvmgvvlillvifg yisadrmakrqsedieaivrkiddaknrhlgsyeplkkhseleeinnyiydlfesneqli qsieqterrlrdiqlkeierqfqphflfntmqtiqyliplspkvaqtviqqlsqmlrysl rtashtvklaeelsyiqqyvaiqnirfddmiqlyidapedvqhqtigkmmlqplvenaik hgrgseplkitirirltkrklhilvhdngigmspshlervrqslhhdvfdtthlglnhlh nraiiqygtyarlhifsrshqgtlmcyqiplv 296. vddvtkygpvdgdpitsteeipfdkkrefdpnlapgtekvvqkgepgtktittpttknpl tgekvgegeptekitkqpvdeivhyggeeiktghkdefdpnapkgsqttqpgkpgvknpd tgevvtppvddvtkygpvdgdpitsteeipfdkkrefdpnlapgtekvvqkgepgtktit tpttknpltgekvgegeptekitkqpvdeivhyggeeikpghkdefdpnapkgsqedvpg kpgvknpdtgevvtppvddvtkygpvdgdxitsteeipfdkkrefdpnlapgtekvvqkg epgtktittpttknpltgekvgegeptekitkqpvdeiteyggeeikpghkdefdpnapk gsqedvpgkpgvknpdtgevvtppvddvtkygpvdgdpitsteeipfdkkrefdpnla pg tekvvqkgepgtktittpttknpltgekvgegeptekitkqpvdeivhyggeeiktghkd efdpnapkgsqttqpgkpgvknpdtgevvtppvddvtkygpvdgdpitsteeipfdkkre fdpnlapgtekvvqkgepgtktittpttknpltgekvgegeptekitkqpvdeivhygge eikpghkdefdpnapkgsqedvpgkpgvknpdtgevvtppvddvtkygpvdgdsitstee ipfdkkrefdpnlapgtekvvqkgepgtktittpttknpltgekvgegeptekitkqpvd eivhyggeqipqghkdefdpnapvdsktevpgkpgvknpdtgevvtppvddvtkygpvdg dsitsteeipfdkkrefdpnlapgtekvvqkgepgtktittpttknpltgekvgegkste kvtkqpvdeiveygptkaepgkpaepgkpaepgkpaepgtpaepgkpaepgtpaepgkpa epgkpaepgkpaepgkpaepgtpaepgtpaepgkpaepgtpaepgkpaepgtpaepgkpa esgkpvepgtpaqsgapeqpnrsmhstdnknqlpdtgenrqanegtlvgsllaivgslfi fgrrkkgnek 297. atgaataaacagatttttgtcttatattttaatattttcttgatttttttaggtatcggt ttagtaataccagtcttgcctgtttatttaaaagatttgggattaactggtagtgattta ggattactagttgctgcttttgcgttatctcaaatgattatatcgccgtttggtggtacg ctagctgacaaattagggaagaaattaattatatgtataggattaattttgttttcagtg tcagaatttatgtttgcagttggccacaatttttcggtattgatgttatcgagagtgatt ggtggtatgagtgctggtatggtaatgcctggtgtgacaggtttaatagctgacatttca ccaag ccatcaaaaagcaaaaaactttggctacatgtcagcgattatcaattctggattc attttaggaccagggattggtggatttatggcagaagtttcacatcgtatgccattttac tttgcaggagcattaggtattctagcatttataatgtcaattgtattgattcacgatccg aaaaagtctacgacaagtggtttccaaaagttagagccacaattgctaacgaaaattaac tggaaagtgtttattacaccagttattttaacacttgtattatcgtttggtttatctgca tttgaaacattgtattcactatacacagctgacaaggtaaattattcacctaaagatatt tcgattgctattacgggtggcggtatatttggggcacttttccaaatctatttcttcgat aaatttatgaagtatttctcagagttaacatttatagcttggtcattattatattcagtt gttgtcttaatattattagtttttgctaatgactattggtcaataatgttaatcagtttt gttgtcttcataggttttgatatgatacgaccagccattacaaattatttttctaatatt gctggagaaaggcaaggctttgcaggcggattgaactcgacattcactagtatgggtaat ttcataggtcctttaatcgcaggtgcgttatttgatgtacacattgaagcaccaatttat atggctataggtgtttcattagcaggtgttgttattgttttaattgaaaagcaacataga gcaaaattgaaagaacaaaatatg 298. atgctattttatttatttcattttacaatcagctttatatcaacagtacttttctctatc attttcaatgcacccaaacgcctcttagtagcatgtggatttgtgggtgccattgcatgg acgatttaccaattaacggtagatttagagtttggaaaagttggcgcttcatttttggga agcttaattttaggcttaatgagtcatactatgagtcgcagatataaacgaccggtaatt atattcatagtgccaggcattataccattagtacctggtggtgcagcttatcaagcgact cgttttttagtatcaaatgattatacaagtgctgtaaatacatttttagaagttacactg atttcaggtgcgattgctttcggtatattagtttctgaaattctatattacctatacaca cgtatcaaacaactgtatggtaaaatcaaaggtaagacatataaaaaatcttacaacatg aataatagagtt 299. atgataaatgcagtagtaatagcagtaattttaatgattatgctatgtttatgtcgatta aacgtagttataagcttatttatcagtgcgctagttggtggcttaatttcaggcatgagc attgaaaaagttataaatgtatttgggaaaaatatagtcgatggtgctgaggtagcatta agctatgctttattaggtggatttgcagcattaatttcatacagtggtatcacagactat ttagtaggaaaaattataaatgcaattcacgctgaaaatagtcgatggtcaagagttaaa gtcaaagtgacaataatcattgcattattagctatgagtatcatgagtcaaaacttaatt cctgtacatattgcattcattccaattgtcatcccaccattgttaagtctgtttaatgac ttaaaaatagatagacgtttaatcggtttgattatcggttttggtttatgtttcccgtat gtgttattaccatatggattcggtcaaattttccagcaaattattcaaagtggctttgca aaggcaaatcacccaattgagtttaatatgatttggaaagcaatgcttattccttcaatg gggtatattgttggcttacttatcggtttatatgtatatcgtaaaccacgtgaatatgaa acacg taaaatttcagatagtgacaatgttacagagttaaaaccatatatcttaatagta acaattgtagcaatactagctacatttttagtacaaacatttacagattcaatgattttt ggtgcactggcaggggtactcgtattctttatttcacgtgcatataattggtatgaatta gatgctaagtttgttgaaggtattaaaattatggcttatattggtgtagttattttaaca gcaaatggatttgctggtgtaatgaatgctactggtgatatagatgaattagttaaaact ttaacaagtattactggtgataataaattatttagcattatcatgatgtatgtgataggt ttaattgtcactttaggtattggatcatcatttgcaacaattcctattatcgcatcatta ttcattccttttggagcgtcaattggactagatacaatggcattaatcgcattgattgga acagcgagtgcattaggtgactcaggttcgcctgcaagtgattcaacattaggaccaact gcgggattaaatgttgatggccaacatgatcatatacgtgatacatgtgtaccaaacttc ttgttttataatattcctttaatgattttcggtactattgctgctatggtacta 300. atgaatcataatgttattatcgttattgcattaatcatagttgtcatttctatgttagct atgctcattcgcgttgtgctaggcccatcacttgccgatcgtgttgtcgcattagatgcg attggtcttcaattaatggcagttatagcattattcagtattttattaaatattaaatac atgattgtcgttattatgatgattggtatattagcttttttaggtactgcagtattctct aaatttatggacaaaggtaaggtgattgaacatgatcaaaatcatactgat 301. gtgaataggaatatcgttaaactagttgtgttca tgctaattttagttgtagcagtagcg ggttgtggtcaaaaagatactgaagagaaaactgaaatgacgacaataaaagatgaatta ggaactgaaaaaattaagaaaaatcctaaacgtgttgttgtattagaatatagttttgct gattatttagcagcattagatatgaaacctgttggtattgcagatgatggcagcactaaa aatataacaaagtcagtaagagataagattggggcatatgaatcggttggatctagaccg caaccgaatatggaagtgataagtaaattaaaaccggatttgatcattgcagatgttagc agacataagaaaatcaaatcagaattgagcaaaattgctccgacaatcatgttagttagc ggtacgggagattataatgcaaatattgaagcatttaaaacagtcgctaaagcagtaggc aaagagaaagaaggcgagaagcgtctggaaaagcatgataaaatattagcggagattaga aagaaaattgaacagagtacgttaaaatctgcatttgcattcggtatctcaagagcaggt atgtttattaataatgaagatacatttatgggacaattcttaattaaaatgggtattcaa cctgaagtcacaaaagacaaaactacgcatgttggtgaacgcaagggtggtccttatata tatttaaataatgaagaacttgccaatatcaatccaaaagttatgattttagccactgac ggaaaaacggacaaaaatagaacgaaattcattgatcctgcagtttggaaatcattaaaa gctgtgaaagataacaaagtttatgacgttgaccgaaataagtggttgaaatcaaggggg attatcgcaagtgaaagtatggcagaagatttagaaaaaattgcagaaaaagcaaaa 302. atgactggagaacaatttactcaaattaaacgtccagtaagtagattaactgaaaa agtt ctaggttggttatgttgggtgatgttattagtgcttactgtcattacgatgtttatagca cttgtttcattcagtaataacacatcgattgctaatcttgaaaatacattaaacaataat gcatttatccagcaattattagctggaaatggctataatacaacacaatttgtaatatgg ttacaaaatggtatatgggctattatcgtttactttattgtttgtttgttgatttcattt ttagctctcatatctatgaatataagaatcttgtcaggtttcttattcttaatatcagca attgtaacgattcctttagttttacttatcgttactttaatcattccgatattattcttt attattgcgatgatgctatttataagaaaagataaagttgaaatggttgcgccacaatat tatgaagagtataacggaccgatttatgattatcgtgaacctgtgtatgagcgcccccaa ccgaaagatgattattatgatgtgcctaaatatgaaaaagaattggataaatcaaatact gtatatgatcaagaacaggaaagagataaatatgatcaatttcctaaacgtgcagttgaa agtgaatataatcatgatgagcgcactgaggaagaaccatcagtattatccagacaggct aaatacaaacaaaaaagtactgaagaactaggtattgaagatgatggttattatgcagaa cctgaagttgatccaaaagaattgaaagcacaacaaaagcgagaaaaagctgaaattaaa gctaagaaaaaagaaaaacgtaaagcttataaccaacgaatgaaagaacgtaggaaaaat caacctagcgcagttagtcaacgtcgaatgaattttgaagagcgacgtcaaatttacaac aatgatatttctgaagaacgcaattcaagtgaagttaaggacaaaaaagagcaagaa 303. gtggaaaatacaattaa tgaaagtgaaaagaaaaaacgatttaaattaaaaatgccaggt gcatttatgattttattcattttaacggttgttgcagttatagcaacatgggttattcct gctggtgcatattctaaactttcttacgaaccttcatcccaagaactaaagatagttaac cctcataaccaagtgaaaaaggttccgggtacgcaacaggaactagacaaaatgggggtt aaaattaagattgaacaatttaaatcaggtgcaattaataagccggtatcaattccgaat acttatgaaagattaaagcaacatccagctggaccagaacaaataacaagtagcatggtt gaaggtacgatagaagcggtcgatatcatggtattcattcttgtactagggggacttatt ggcgtagttcaagccagtggttcttttgaatcgggattgttagctttaacgaagaaaaca aaagggcatgaatttatgctaattgtgtttgtatcaatactaatgattatcggcgggaca ttatgtggtattgaagaagaagctgtagcattttatccgattttagtccctatatttata gcgttaggatacgattctatcgtttcagttggtgccatattccttgccagctctgtcggt agtacattttcaactattaacccgttctcggttgtaattgcctctaatgccgctggtaca acttttacggatggcttgtattggagaataggtgcttgtattgtcggtgcgatttttgtt attagttatttatattggtactgtaaaaaaattaaaaacgatcctaaagcgtcatattct tatgaagacaaagatgcttttgaacagcaatggtctgtattaaaagatgacgatagtgcc cattttactttgcgtaagaagataatccttacattatttgtactaccatttccaattatg gtatggggagttatgacgcaaggttggtggttcccagttat ggcttcagcatttttaata tttacaattataataatgtttattgctgggacaggtaaatctggattgggagaaaaagga actgtagatgcatttgtcaatggtgcatcaagtttagtaggtgtatctttaattattggt ttagctcgaggtattaatttagtgttgaatgaaggtatgatttcagatacaatcttacac ttttcatcatctttagttcaacatatgagtggaccattatttatcatcgtattactattt attttcttctgtttaggttttatcgtgccatcatcttctggcttagcggtattatcaatg cctatctttgcaccactagctgatacagtaggtataccaagattcgtcatcgttacgaca tatcaatttggtcaatatgcgatgttattcttagcgccgactggacttgttatggccaca ctacaaatgttaaacatgcgatattcacattggttccgatttgtatggccggtagttgct tttgtattgattttcggtggcggagtactaattacgcaagtactaatttattca 304. atgagcttttttaaacgcttaaaagataagtttgcaacaaataaagaaaatgaagaagtt aaatccttaacagaagaacaaggtcaagacaaattagaagatacacattctgaaggttca acgcaggacgcaaatgatttagcagaaaatgctgaagtgaaaaagaagccacgcaagttg agtgaagcggattttgatgacgatggcttaatatcaattgaagattttgaagaaattgaa gctcaaaaaatgggtgctaaatttaaagcaggactcgaaaaatctcgtcaaaatttccaa gaacaattaaataatttgatagcgagatatcgtaaagtagatgaagacttttttgaagct ttagaagaaatgttaatcactgcagacgtcggttttaatacagtgatgacgttaactgaa gaatt acgtatggaagcacaacgacgtaatattcaagatactgaagatttgcgtgaagtc attgttgaaaaaatcgtagagatttaccatcaagaagatgataattcagaagctatgaac ttagaagatggtcgtttaaatgtcattttaatggttggtgtgaatggtgttggtaaaaca acaacaattggaaaattagcttaccgatataaaatggaaggtaaaaaagtaatgttagct gcgggcgatacttttagagcgggtgctattgatcaattgaaagtttggggcgaacgtgtt ggtgtagacgtaattagccaaagtgaaggttctgatccagctgctgttatgtatgatgcg attaatgccgctaaaaacaaaggtgttgatattttaatctgtgataccgctggacgttta caaaataaaacaaatctaatgcaagaattagaaaaagttaagcgtgtaattaatcgagca gtgccagatgcgcctcatgaagcattactatgtttagatgctacaactggtcagaatgcg ttgtcacaagctagaaactttaaagaagtaacaaatgttacaggtattgtattaacgaaa ttagatggtacagccaaaggtggtatcgtattagccattcgtaatgaattgcacatccca gttaaatatgtaggtttaggtgagcaattagatgacttacaaccatttaaccctgaaagt tatgtctacggcttattcgctgatatgattgaacaaaatgaagaaataacaacagttgaa aatgatcaaattgtaacagaagaaaaggacgataatcatgggtcaaaa 305. gtgttaaaaaagtggctaaattcaaacgtcaaacaattctttgttataactttcattagt gtaatattaacgcttattttattttctactcatatctatgattatattgtgaatggtact gtttttagcggggctggagatggattccgtcaaatg atgccatttcaaatgtatttgtat gaacatctacgtagtttttctagtttatatgatgcatcgtttggattaggtggcgattat atgaaaggactatcatattattattcgctgtcacctttaatgtggctaaattttctattc attaaaataggagaaacggttggtatatttaatccgacgacaatacatttttggccgaca aaccaacttattatggctatgatacgagctatcataacatttgtcgtgaccttctactta tttaaaatattacactttaaacgctcagcaaatatgatcgctacgattttatacggcatg tcaactgtcgttatatactttaattttacttggtcattttatggaaatttattatattta ttgccattatcgattcttggtttggaaagatattttcaacaacgcaaaatcggtattttc attgttgcgatagccttaacactatttagcaatttttatttcagttattatcaagctatt attataggttgctactatttatatcgactcattttcacttacaaatatgacattgtctct agaacacaaaaattaatttgcgtcatatctgctacagttttgagtgtgttatcaagtgta tttggtttattcactggcatttctgcgtttttggaaaatgacagaaagcaaaatcccaat gttgatataccgtttttgacaccacttgattatcattattttttctttagcgatggattt tatattacgatttcaattcttactatcgttgcattattgtcattcaaactgtatcgtttt tacttttatagacttttcgcaatagtaacatggatattatttataggttcattatcacag tatttcgacagtgcttttaatggtttttcatttccagaaaggcgttgggtgtatatctta gcactatcatcaagtgctctttgcggattgtttattcaacatttatcaacattaaatatg aaatattatttaatcagaacaatacccgtatgcatcatcgcaatactttatgtattacta tcaccgacacacccacttgcacttatagtaggtattatcctgctaatagtgcttgccgtt attttaaaatttagtttatggcgttataaaaaattaaccgttgcaatattagtattaatc gttatgattcaacaaatcgtcattttagataacaacaaaaacatggcaatcaaaccttat caacaatcattatcaacgttgaaacaacatgattaccatagtaactatgtaaaccagctt ataaaaaagataaatcaaaatgcaacaggctcatttaatcgcattgattatatgtcagac tatgcattaaattcaccatttatatatcattataatggcatttcattatattctagtatt tttaatggagacattttaaaatattatgacaagacactccaaattaatatgccaatcgat aaaaacagcacttatagattacttggcaatcgtcaaaatttactatcactttggaatgtt aatgatcgaattagagtgaatcatgatgacaacttaccatatggatttaaaattaagtct gaacacaaagacaataaagttcgttggattcattctaaaaataccatccattatccaagt gcacatattacaaataaggtcttttccaataaagaattaaaatctccattagataaagaa caagcaatgttgcaagggattgtttctaacaatattaaagatgttaatacacattttaaa gccaataaaaatttactatcagattcaacaattaaattaaatagtgcagcctggcaatct cctacaaaacatttattacaagttaaacaaaataatggtggtctaactgtacagttgcca aaatcagtttctaatcaatttaaagatttgtattttgaaatggatttagaattactttcg ccggataaagctcatgatgttaa agtgaatgaatatacacaagaaagaaataaactcact tataaatatcgacgcgttgtaacacccgtaacgatacgcattaaagctccagatagaatt agattatcattgcctaaaggtaagtatcgagtaaatttaaaagggatatacggcgaagat tataccacgcttaaagacgcttcaaattcattagaagctgtcaaagttagtaagacaaag catggttatactattactaaaaataaaaattcatctgggtatattgttttgccaacagca tataatcaaggtatgaaagcgacatcaggtgatcaaagtcttaaagttgaacaagtaaat ggtgttatgaccggcattaaagcacctaaaaatataacaaagattcaattgagctatacc ccaccatactattatttacttataacaattactatatttggcattatatgtagtattatt ttcacgagatgggcaagacaaaaa 306. gtgcgtcaattggcacaagcaaaaaagaaatcgacagctaagaaaaaaacaacatcaaaa aaaagaacaaattcgaggaaaaagaagaatgataatccgatacgttatgtcatagctatt ttagtagttgtattaatggtgttgggtgttttccaattaggaataataggtcgtctaatt gacagcttctttaattatttatttgggtacagtagatatttaacatatattttagtactc ttagcaactggttttattacatactctaaacgtattcctaaaactagacgaacggctggt tcgattgtattgcaaattgcattgctatttgtatcacagttagtttttcattttaatagt ggtatcaaagctgaaagagaacctgtactttcttatgtgtatcagtcataccaacacagt catttcccaaattttggtggcggtgtattaggcttttatttattagagttaagcgtacct ttaatttcattatttgg tgtatgtattattactattttattattatgctcaagtgttatt ttattaacaaaccatcaacatcgtgaagttgcaaaagttgcactggaaaatataaaagct tggtttggttcatttaatgaaaaaatgtcggaaagaaaccaagaaaaacaattgaagcgt gaagaaaaagcaagacttaaagaagaacaaaaggcacgtcaaaatgaacagccacaaata aaagatgtgagtgattttacggaagtgcctcaagaaagagatattccaatttatgggcat actgaaaatgaaagtaaaagccagagtcaaccaagtcgaaaaaaacgagtgtttgatgca gagaatagttcgaataacatcgtaaatcatcatcaagcagatcagcaagaacaattaaca gaacaaactcataacagtgttgaaagtgaaaacactattgaagaagctggtgaagttacg aatgtatcgtatgttgttccaccgttaactttacttaatcaacctgcaaaacaaaaagca acatctaaagctgaagtgcaacgtaaaggacaagtactagagaatacattaaaagatttt ggggtaaatgcaaaagtgacacaaattaaaattggtcctgcagtaactcaatatgaaatt caaccagctcaaggggttaaagtgagtaaaattgtaaacttgcataatgatattgcatta gctttagcagcaaaagatgttagaatcgaagcgccaatacctggtcgttctgcagtaggt attgaagtgccaaatgagaaaatttcattagtttcactaaaagaagttttagatgaaaaa ttcccgtctaataataaactagaagttggattaggaagagatatatcaggtgatccaatt actgttccactaaatgaaatgccacacttattggtggcaggatcgacgggtagtggtaaa tctgtttgtataaatggtattattacaagtattttattaaa tgctaagccgcatgaagtt aaacttatgttaatcgatccgaaaatggttgaactaaatgtttataacggaattccacac ttattaattccggttgttacaaatcctcataaagctgctcaagctttagaaaaaattgta gctgagatggaaagacgttatgatttattccaacattcatcaactagaaacattaaaggt tataacgaattaatccgtaagcaaaatcaagaattagatgagaagcaaccagaattacct tatatcgttgttattgtagatgagcttgcagatttaatgatggtagctggtaaagaagtt gaaaatgcgattcaacgtattacacaaatggcacgtgcagcaggtatacatttaattgta gcgacacaaagaccttctgtggatgtaattacaggtatcattaaaaataatattccatct agaatagcttttgctgtgagttctcaaacagattcaagaactattattggtactggcggc gcagaaaagttacttggtaaaggtgacatgttatacgttggaaatggtgactcatcacaa acacgtattcaaggggcgtttttaagtgaccaagaggtgcaagatgttgtaaattatgta gtagaacaacaacaggcaaattatgtaaaagaaatggaaccagatgcaccagtggataaa tcggaaatgaaaagtgaagatgctttatatgatgaagcgtatttgtttgttgttgaacaa caaaaggcaagtacatcattgttacaacgccaatttagaattggttataatagagcatct aggttgatggatgatttagaacgcaatcaggtaatcggtccacaaaaaggaagcaagcct agacaagttttaatagatcttaataatgacgaggtg 307. atggctgaaaaattacaaagggaactgagcaatcgccacatacaattaattgcaattggc ggtgcaattggtacaggcttatt cttaggtgctggtcaaacgattgcattaaccggccct tcaattctattaacatacatcattataggatttatgttatttatgtttatgcgaggttta ggagaaatcattatacagaatactgaatttaaatctttcgcagatgtaaccaatacatat attgggccttttgcaggatttgttaccggatggacatactggttctgttggattattaca ggtatggctgaagtaacggctgtggcaaaatatgttagcttttggttcccagaaattcca aactggataagtgcactattttgtgtactgttattaatgtcattcaacctacttagcgca agacttttcggagaattagaattttggttctctatcattaaaatagcgacaattattggt ttaatagtagttggtttcgtcatgattctatttgcatttaaaactcaattcgggcatgcc agtttcacaaatctatatgaacacggcatattcgctaaaggtgcttctggattctttatg tctttccaaatggcactattctcatttgtaggaattgaaatgattggtgttacagctggg gaaacaaaagatccagttaaaacaattccaaaagcaattaacagtgtacccattagaatt ttaatattttacgttggggcgttagcggttatcatgtctattatcccttggcagcaagtt gatcctgataacagtccattcgtaaaattattcgcattgatcggaattccgtttgctgcg ggcttgattaattttgtagtattaaccgctgctgcttcatcatgtaacagtggtatattc tcaaatagccgtatgcttttcggtttatcaagtcaacaacaagcacctccgaacttttct aagacgaataaatatggcgttccacatgttgcaatctttgcttcatcagcattattactt gtggcagcattactaaactatattttcccagatgcgacaaaagtatt tacgtatgtgact accatctctacagtgttatttttagttgtatggggtctgattatcattgcatatatcaat tatagtcgtaaaaacccagatctacataaaaatgctacgtacaaactattaggtggcaaa tatatgggctacttaatatttgtattcttcatttttgtgttcgggttattatttattaat gttgatacaagacgtgcaatttattttattccgatttggtttatacttttagcatttatg tacttaagatataaacgtatcgctgctaaatcaaataaa 308. atgaatttgttaaagaaaaataaatatagtattaggaagtataaagtaggcatattctct actttaatcggaacagttttattactttcaaacccaaatggtgcacaagccttaactacg gataataatgtacaaagcgatactaatcaagcaacacctgtaaattcacaagataaagat gttgctaataatagaggtttagcaaatagtgcgcagaatacacctaatcaatctgcaaca accaatcaagcaacgaatcaagcattggttaatcataataatggtagtatagtaaatcaa gctacgccaacatcagtgcaatcaagtacgccttcagcacaaaacaataatcatacagat ggcaatacaacagcaactgagacagtgtcaaacgctaataataatgatgtagtgtcgaat aataccgcattaaatgtaccaactaaaacaaatgaaaatggttcaggaggacatctaact ttaaaggaaattcaagaagatgttcgtcattcttcaaataaaccagagctagttgcaatt gctgaaccagcatctaatagaccgaaaaagagaagtagacgtgcggcaccggcagatcct aatgcaactccagcagatccagcggctgcagcggtaggaaacggtggtgaaccagttgca attacagcgccatatacgccaacaac tgatcctaatgccaataatgcaggacaaaatgca cctaacgaagtgctgtcatttgatgacaatggtattagaccaagtaccaaccgttctgtg ccaacagtaaacgttgttaataacttgccgggcttcacactaatcaatggtggcaaagta ggggtgtttagtcatgcaatggtaagaacgagcatgtttgattcaggagataataagaac tatcaagcacaaggaaatgtaattgcattaggtcgtatacatggaactgatacgaatgac catggcgattttaatggtatcgagaaagcattaacagtaaatccgaattctgaattaatc tttgaatttaatacaatgactactaaaaacggtcaaggcgcaacaaatgttattatcaaa aatgctgatactaatgatacgattgctgaaaagactgttgaaggcggtccaactttgcgt ttatttaaagtacctgataatgtgagaaatctcaaaattcaatttgtacctaaaaatgac gcaataacagatgcgcgtggcatttatcaactaaaagatggttacaaatactatagcttt gttgactctatcggacttcattctgggtcacatgtttttgttgaaagacgaacaatggat ccaacagcaacaaataataaagagtttactgtaacaacatcattaaagaataatggtaat tctggtgcttctctagatacaaatgactttgtatatcaagttcaattacctgaaggtgtt gaatatgtgaacaattcattgactaaagattttccaagtaacaattcaggcgttgatgtt aatgatatgaatgttacatatgatgcagcaaatcgtgtgataacaattaaaagtactgga ggaggtacagcaaactctccggcacgacttatgcctgataaaatactcgatttaagatat aaattacgtgtaaataatgtgccgacaccaagaacagtaacatttaacga gacattaacg tataaaacatatacacaagatttcattaattcagctgcagaaagtcatactgtaagtaca aatccatatactatcgatatcatcatgaataaagatgcattacaagccgaagttgacaga cgtattcaacaagctgattatacatttgcgtcattagatatctttaatggtctgaaacga cgcgcacaaacgattttagatgaaaatcgtaacaatgtaccattaaataaaagagtttct caagcatatattgattcattaactaatcaaatgcaacatacgttaattcgaagtgttgat gctgaaaatgcagttaataaaaaagttgaccaaatggaagatttagttaatcaaaatgat gaattgacagatgaagaaaaacaagcagcaatacaagttatcgaggaacataaaaatgaa ataattggtaatattggtgaccaaacgactgatgatggcgttactagaatcaaagatcaa ggtatacagaccttaagtggggatactgcaacaccggttgttaaaccaaatgctaaaaaa gcaatacgtgataaagcaacgaaacaaagggaaattatcaatgcaacaccagatgttact gaagacgagattcaagatgcactaaatcaattagctacggatgaaacagatgctattgat aatgttacgaatgctactacaaatgctgacgttgaaacagctaaaaataatggcatcaat actattggagcagttgttcctcaagtaactcataaaaaagctgcaagagatgcaattaac caagcaacagcaacgaaaagacaacaaataaatagtaatagagaagcaactcaggaagag aaaaatgcagcattgaacgaattaactcaagcaaccaaccatgctttagaacaaatcaat caagcaacaacaaatgctgatgttgataacgccaaaggagatggtctaaatgccattaat ccaattgctcctg taactgttgttaagcaagctgcaagggatgccgtatcacatgatgca caacaacatatcgcagagatcaatgctaatcctgatgcgactcaagaagaaagacaagca gcaattgacaaagtgaatgctgctgtaactgcagcaaacacaaacattttaaacgctaat accaatgctgatgttgaacaagtaaagacaaatgcgattcaaggaatacaagcaattaca ccagctacaaaagtaaaaacagatgcaaaaaatgccatcgataaaagtgcggaaacgcaa cataatacgatatttaataataatgatgcgacgctcgaagaacaacaagcagcacaacaa ttacttgatcaagctgtagccacagcgaagcaaaatattaatgcagcagatacgaatcaa gaagttgcacaagcaaaagatcagggcacacaaaatatagtagtgattcaaccggcaaca caagttaaaacggatactcgcaatgttgtaaatgataaagcgcgagaggcgataacaaat atcaatgctacaactggcgcgactcgagaagagaaacaagaagcgataaatcgtgtcaat acacttaaaaatagagcattaactgatattggtgtgacgtctactactgcgatggtcaat agtattagagacgatgcagtcaatcaaatcggcgcagttcaaccgcatgtaacgaagaaa caaactgctacaggtgtattaaatgatttagcaactgctaaaaagcaagaaattaatcaa aacacaaatgcaacaactgaagaaaagcaagtggctttaaatcaagtggatcaagagtta gcaacggcaattaataatataaatcaagctgatacaaatgcggaagtagatcaagcgcaa caattaggtacaaaagcaattaatgcgattcagccaaatattgttaaaaaacctgcagca ttagcacaaatcaatcagcattataatgctaaattag ctgaaatcaatgctacaccagat gcaacgaatgatgagaaaaatgctgcgatcaatactttaaatcaagacagacaacaagct attgaaagtattaaacaagctaacacaaatgcagaagtagaccaagctgcgacagtagca gagaataatatcgatgctgttcaagttgatgtagtaaaaaaacaagcagcgcgagataaa atcactgctgaagtggcgaagcgtattgaagcggttaaacaaacacctaatgcaactgac gaagaaaagcaggctgctgttaatcaaatcaatcaacttaaagatcaagcaattaatcaa attaatcaaaaccaaacaaatgatcaggtagacacaactacaaatcaagcggtaaatgct atagataatgttgaagctgaagtagtaattaaaccaaaggcaattgcagatattgaaaaa gctgttaaagaaaagcaacagcaaattgataatagtcttgattcaacagataatgagaaa gaagttgcttcacaagcattagctaaagaaaaagaaaaagcacttgcagctattgaccaa gctcaaacgaatagtcaggtgaatcaagcagcaacaaatggtgtatcagcgattaaaatt attcaacctgaaacaaaagttaaaccagctgcacgtgaaaaaatcaatcaaaaagcgaat gaattacgtgctaagattaatcaggataaagaagcaacagcagaagaaagacaagtagca ctagataaaatcaatgaatttgtaaatcaagccatgacagatattacgaataatagaaca aatcaacaagttgatgatacaacaagtcaagcgcttgatagcattgctttagtgacgcct gaccatattgttagagcagctgctagagatgcagttaagcaacaatatgaagctaaaaag cgcgaaattgagcaagcggaacatgcgactgatgaagaaaaacaagttgctttaaatcaa ttagcgaataatgaaaaacgtgcattacaaaacatcgatcaagcaatagcgaataatgat gtgaaacgtgttgaaacaaatggcattgctacactaaaaggtgtacaacctcatattgta attaagcctgaagcacaacaagcaataaaagcaagtgcagaaaatcaagtagaatcaata aaagatacaccacatgcaacagttgatgaattagatgaagcgaatcaattaattagcgac acactcaaacaagcgcaacaagaaatagaaaatacaaatcaagatgctgctgttactgat gttagaaatcaaacaatcaaggcaatagagcaaataaaacctaaagtaagacgtaaacga gctgcgcttgatagcattgaagaaaataataaaaatcaactcgatgcaatccgaaatacg ttggatactactcaagatgaaagagatgttgctattgatactttaaataaaattgtaaat acaattaaaaatgacattgcacaaaacaaaacgaatgcagaagtggatcgaactgagact gatggcaacgacaacatcaaagtgattttacctaaagttcaagttaaaccagcagcgcgt caatctgttggtgtaaaagccgaagctcaaaatgcactaatcgatcaaagcgatttatca actgaagaagaaagactagctgctaaacatttagtagaacaagcacttaatcaggctatt gatcagatcaatcatgcagataagactgcccaagttaatcaagatagtataaatgctcaa aatattatttcaaaaattaaaccagcgacaacagttaaagcaacagcattacaacaaatt caaaatatcgctacaaataaaattaatttaattaaagcaaataacgaagcgacagatgaa gaacaaaatattgcaatagcacaagttgaaaaagagttaattaaagctaaacaacaaatt gctagtgcagtgactaatgcagat gtggcatatttattgcatgatgagaaaaacgaaatt cgtgaaatcgaacctgttattaacagaaaggcgtctgctcgagaacaattgacaacatta ttcaacgataaaaaacaagcaattgaagcgaatattcaagcaacggtagaagaaagaaat agtatattagcacagttacaaaatatttatgacactgctattggacaaattgatcaagat cgtagcaatgcacaagttgataaaacagcatcattaaatctacaaacaatacatgattta gatgtacatcctattaaaaagccagatgctgaaaaaacgattaatgatgatcttgcacgc gtcactgctttagtgcaaaattatcgaaaagtaagtaatcgtaataaggctgatgcatta aaagctataactgctttaaaattacaaatggatgaagaattaaaaacagcacgcactaat gctgatgttgatgcagttttaaaacgatttaatgttgcattaagcgatatagaagcagta attactgaaaaagaaaatagcttactgcgaattgataacattgctcaacaaacatatgcg aaattcaaagcgatcgcaacaccagaacaattagctaaagtaaaagtattaattgatcaa tatgttgcagatggcaatagaatgattgatgaagatgcgacattaaatgacatcaaacaa cacacgcaattcattgttgatgaaattttagcaattaaattaccagctgaagcgacgaaa gtatcaccaaaagaaattcagccagctccaaaagtttgtacgcctattaaaaaagaagag acacatgaatcgcgcaaagttgaaaaagaacttccaaatacaggttctgaaggaatggat ttaccattgaaagaatttgcactgattacaggtgcggctttgttagctagaagacgtact aaaaacgaaaaagaatca 309. atgagtgttgaaatagaatcaatt gaacatgaactagaagaatcaattgcatcattgcga caagcaggcgtaagaattacacctcaaagacaagcaatattacgttatttaatttcttca catactcatccaacagctgatgaaatttatcaagcactttcacctgattttccaaatata agtgttgcgacaatatataataacttaagagtgtttaaagatattggaattgtaaaagaa ttaacatatggagactcatcaagtcgattcgactttaatacacataatcattatcatatt atatgtgaacaatgtggtaagattgttgattttcaatatccacagttaaatgaaattgaa agattagctcagcatatgactgactttgacgtaacacatcatcgaatggaaatttatgga gtttgtaaagaatgccaagataaa 310. atgagtgaaaaacaacaaattctcgattatatagaaacaaataaatatagttatatcgaa atcagtcatagaattcatgaacgtcctgaacttggtaatgaagaaatatttgcgtctcga actttaatagatcgtttgaaagagcatgattttgaaattgaaaccgagattgctgggcat gcaactgggtttatagcgacatatgattcaggacttgacgggccagctataggtttttta gcagaatacgatgctttgccaggattgggtcatgcttgtggtcataatatcattggaact gcaagtgttcttggtgcaattggtttgaagcaagtgattgaccaaattggtggtaaagta gtcgttcttggatgtccagctgaagaaggtggggaaaatggtagcgctaaagcttcttat gtcaaggctggtgtgattgatcaaatagacattgccttaatgattcatccgggaaatgaa acttataaaacgattgatactttggcagtggatgttttagatgttaaattttacggaaaa agtgctcatgcctctgaa aatgcagatgaagcgttaaatgcattagacgctatgattagt tattttaatggtgtagcacaactacgacaacatattaaaaaagatcaacgtgtgcatggt gtgattttagatggcgggaaagcagctaatattattccagactatacacatgctcgtttt tatactagagcaatgacgcgtaaagaattggatatattaacagaaaaagtaaatcaaatc gcacgtggagctgcgatacagactggttgtgattatgaatttggtcgaattcaaaacggt gtgaatgaattcattaaaacgccgaaattagatgatttatttgctaaatatgctgaagaa gttggtgaagcagttattgatgatgattttggttatggctctacggatacagggaacgta agtcatgttgtgccaacaatacatcctcatattaaaataggatcacgtaatttagtagga catacgcatagatttagagaagcggctgcgagtgtacatggtgatgaagcattaattaaa ggcgctaaaataatggcgttgatggggttagagttaattacaaatcaagacgtttatcaa gacattattgaagagcatgcgcatttgaaagggaatgggaag 311. atgactacgaccttcattattagctacattattttagcgctcattattgttggggttatc aatttatttttaataagatcaagaaaaaaaggcaaacgccaacaaaaggaacaacaattt acgacacgtcaatcaaatcaatctaaatttaaagctagtgatttagacaaaacaactgat caatcgacacaacgtatgacgcatgaagagttgcgtgttgacaatcaagatgatcatagc caagttagtctaaatggttacacaaaggggtctgagaaagatcaagaagcattcactaat aataaggatgaggaagcagttgctgctaaaaatcctgaatcagaagaatataaag tgaat gaaaaaataaaaaaagaacataaaaactttatttttggtgaaggtgtttcacgcggtaaa atattagcggcattattattcggtatgtttattgcgattttaaaccaaacattattaaat gttgctttaccaaaaattaatacggaatttaatatttctgcgtcaacagggcaatggttg atgacgggattcatgttagtaaacggtattttaataccaattacggcgtatctatttaat aaatattcatatcgaaaattatttttagttgcgttagtactctttacaattggttcatta atctgtgcgatttcaatgaatttcccaatcatgatggttggacgtgtattacaagccatt ggtgcaggtgtactaatgccattaggttcaattgttattattacaatttatccacctgaa aaacgtggtgctgccatgggtacaatgggtatcgcaatgattttagcacctgcaattggt ccaacattatcaggttatattgtacaaaattaccattggaatgtgatgttttacggtatg ttcattatcgggattatcgctattttaattggttttgtatggtttaagttatatcaatat acaacaaaccctaaagctgatatcccaggtatcatttttagtacgattggttttggtgct ttgttatatggtttctcagaagctggcaacaaaggttggggttcagtagagatagaaaca atgtttgcgattggtattatctttattattctattcgttattagagaattaagaatgaaa tcaccaatgttgaatttagaagtattgaaattcccaacatttacattaacaacaattatt aatatggttgtaatgttaagtttatatggtggtatgattttattaccgatttatttacaa aatttacgcggattctcagcattagattccggattgttattattacctggttctctaatt atgggtctactaggacca tttgcaggtaaattgttagatactattggtttaaaaccatta gctatctttggtattgctgtaatgacttatgcaacatgggaattaactaaattaaatatg gatacaccatatatgacaatcatgggtatctatgtacttcgttcatttggtatggcattt ataatgatgccaatggtaactgcagctattaatgcgttaccgggacgacttgcctctcat ggtaatgctttcttaaatacgatgcgtcaattagcaggctctataggtacagcaatctta gttactgtaatgacaacacaaactacacaacacttatcagcttttggggaagagttagat aaaacgaatcctgttgtacaagatcatatgcgtgaattagcatcacaatatggcggacaa gaaggcgcaatgaaagtgttactacaatttgtaaataaactagcaacggttgaaggtatt aatgatgcatttatagttgcaacgatatttagcatcatcgccttaattttatgtttattt ttacaaagtaataaaaaagcaaaagctacagctcaaaagttagatgcagataatagtatc aatcatgaa 312. atgattaaaaataaaatattaacagcaactttagcagttggtttaatagcccctttagcc aatccatttatagaaatttctaaagcagaaaataagatagaagatatcggccaaggtgca gaaatcatcaaaagaacacaagacattactagcaaacgattagctataactcaaaacatt caatttgattttgtaaaagataaaaaatataacaaagatgccctagttgttaagatgcaa ggcttcattagctctagaacaacatattcagacttaaaaaaatatccatatattaaaaga atgatatggccatttcaatataatatcagtttgaaaacgaaagactctaatgttgattta attaattatcttcctaaaaataaaatt gattcagcagatgttagtcagaaattaggctat aatatcggcggaaacttccaatcagcgccatcaatcggaggcagtggctcattcaactac tctaaaacaattagttataatcaaaaaaactatgttactgaagtagaaagtcagaactct aaaggtgttaaatggggagtgaaagcaaattcattcgttacaccgaatggtcaagtatct gcatatgatcaatacttatttgcacaagacccaactggtccagcagcacgagactatttc gtcccagataatcaactacctcctttaattcaaagtggctttaatccatcatttattaca acattgtcacacgaaagaggtaaaggtgataaaagcgagtttgaaatcacttacggcaga aacatggatgctacatatgcttacgtgacaagacatcgtttagccgttgatagaaaacat gatgcttttaaaaaccgaaacgttacagttaaatatgaagtgaactggaaaacacatgaa gtaaaaattaaaagcatcacacctaag 313. atgcaatcaacgaaaaccaaaacgaagcatttttcatttttattgctaattacgttaggc gtcatgaccgcttttggcccactaactatagatatgtacgtaccatcattacctaaagtg caaggtgattttggttctactacatcagaaattcaattaacattatcattcacaatgatt ggtcttgcactaggccaatttatctttggacctttatccgatgcttttggtcgcaaacgg attgctgtatccattttgatcattttcattttggtatcaggtttgtctatgtttgttgat caattgccattattcttaactttacgatttattcaaggtttaactggtggtggcgtcatc gtgattgcaaaagcctctgctggtgataaatttagtggcaacgcactcgctaaattttta gcatctttaatggtagtt aatggcatcatcactattcttgcaccattagccggtggatta gctttatccgtagcaacatggcgttctattttcacaattttaactattgtggcactcatc attttaattggcgtcgcttctcaattacctaaaacatctaaagatgaattaaagcaggtg aattttagtagcgtcattaaagattttggaagtcttttgaaaaaaccagcatttattatt ccaatgctattacaaggtttaacttatgtaatgctatttagttattcatctgcatcgcca tttattactcaaaaattgtataatatgacaccccaacaatttagtatcatgtttgctgtt aacggtgtaggtttaatcattgtcagtcaagtcgttgctttattagtagaaaaattacat cgccacatattattaatcattttaactattatacaagtggtaggtgttgctttaattatc ctgacacttacattccatttaccactttgggtcttactcatcgcattcttcttaaatgtg tgtcctgtgacgtcaattggaccgcttggtttcacaatggctatggaagaacgaacaggt ggcagtggtaacgcatcaagtttacttggcttattccaatttatcttaggtggcgctgtt gcaccattagttggcttaaaaggcgaatttaatacatcaccatatatgattattatcttc attacagccattctattagtcagtctacaaatcatttactttaaaatgattaaaaagcaa catgtcgca 314. atgatgtatggatatccagagaaatggttggaaggtatgacaactggagaaggtatcgcg gcagaattacgcttaggcattgtgaatggtcacatagctgaaggtacgttactcactgaa aatcaaatggcaaagcaatttaatgtgagtcgttcgccaattcgagatgcatttaaatta ttgcaacaaaatcaactcatccaatta gaaagaatgggtgcacatgtgttgccgtttggg gaacaagaaaagaaagaaatgtatgatttgcgactgatgttagagtcatttgcattttca agagttaaaaatcaagagcgactacctatcgtaaaagaaatgaagaaacaacttgaaatg atgaaagtggcagtaaaatttgaggatgcagaatcatttacgaagcatgactttgaattt catgaaacattaatcaaagcatctaatcatcaatatttaaactcattttggagtcattta aaaccagtaatgatggcactcgttttaacatccatgcgacaacgtatgcaacagaacccg caagattttgaacgcatacatcataatcatcaagtgtttattgatgcagtggaacaatac gacagtcaaattttgaaagaagcgtttcatttaaatttcgacgatgttggtaaagatatt gaaggattttggttgaat 315. atgggaagttttttcaataaaatagcacgaaaagaggatccggctatctatcaaaataaa gatggtcatttaaagcgtacacttcgggtgcgtgatttcttagctttaggtgtaggaaca attgtatcgacatctatctttacgctacctggcattgttgctgcagaacatgcaggaccg gccgttgcgttatcattcttactcgctgctattgttgctggtttagttgcatttacttat gcagaaatggctgccgctatgccatttgcaggttcagcctattcttgggtcaatgtatta tttggtgaattttttggatgggttgccggttgggctctattagctgaatattttatcgcc gtagcctttgttgcatcaggattctcagcgaatttacgcggacttgtgaaaccaattggc atcgaattacctgcagcattatcaaatccatttggtacaaatggcggttttatcgatatt attgctgctatcgttattttattaact gcattattactatcacgtggtatgtcggaagca gctcgtatggaaaatattttagttattttaaaagtattagctattattttatttgtcatc gtaggtttaacagcaataaatgttagtaactatgtgccatttattccagaacacaaagta actgctacaggtgactttggtggatggcaaggcatatatgctggtgtttcaatgattttc ttagcgtatatcggtttcgattctatcgcagcaaactcagcagaagcacttgatcctcaa aagacaatgcctagaggtattcttggttctttaagcgttgctatcgtattatttattgct gtagcacttgtgttagttggtatgttccattactcacaatacgcaaacaatgctgaacct gttggttgggctttacgtcaaagtggtcatggtgttgtagcagctattgttcaagctatc tctgttatcggtatgtttacagcattaattggtatgatgttagcaggctcacgtttactt tattcatttggacgtgacggcttattaccttcatggttaagccacttaaacgacaaacat ttacctaatcgcgcactagttatacttactattattggtgttttaattggttctatgttc ccattcgcatttttagcacaattaatttcagcaggtacacttgttgcatttatgttcgtt tcattagcaatgtatcgtttgagaaagcgtgaaggtaaagatctaccaattcctgcattt aaattacctttatatcctgtgttaccagcaattacatttgttttagtattgctagtattc tggggattaggattcgaagcgaaattatacactttaatttggtttattgttggtatcatc ctatatttaagttatggacttagacattctaagaaaaatgacgtagctgaataccaccca ccaaaa 316. atgaatagtgataatatgtggttaacagtaatggggctc attattattatttcaattgta ggtttactcattgccaaaaagataaatccagttgtaggtatgacaatcataccttgctta ggggcaatgattttaggatatagtgtgacagatttggttggattttttgctaaagggtta gatcaagtcatcaacgttgttattatgtttatctttgccattattttctttggcatcatg aacgatagtggtttattcaagccgcttgtcaaacgcttaatattaatgacacgaggcaat gtcgtcattgtctgtgcaatgacagctttaattggcacaatagcccaattagatggggcc ggtgcggtaacatttttgctttctattcctgcattattacctttatataaagcgttaaat atgaataaatatttattgattttactattagcattaagcgcggcgattatgaacatggta ccttggggaggtccaatggctcgtgtagctgcagtgttaaaagccaaaagtgtcaatgaa ttatggtatggattaatacctattcaaataataggtttcattcttgttatgttgtttgcg gtatatcttggatttaaagaacagaaacgtatcaaaaaagcaatagagagaaatgaatta ccgcaaacacaagatatagatgtacataaattagttgaagtatatgaacgagatcaagat gtaaggtttcctgtaaaaggacgtgcaagaacaaaatcatggataaaatgggtgaataca gctttaactttagctgttattctatcgatgttaataaatattgcgccacctgaatttgca ttcatgataggtgtttcgttggcacttgttattaattttaaatcagtggatgaacaaatg gaacgattaagagcgcatgcgccgaatgcattaatgatggctgcagtgattattgcagca ggtatgtttttaggtgtactaaatgaaaccggtatgcttaaagcgattgcgaccaattta at caaagtgattcctgcagaagtaggaccatacttgcatattattgtaggtttacttggc gtaccattagatttactaactagcacagacgcttattattttgctgtgttaccgattgtc gaacaaacagcagggcaatttggtgtaccgtctgtatcaacagcttattcaatggtcata gggaatattataggtacatttgtcagcccattttcaccagccttatggttggcaattggt ttagcagaggcaaacatgggcacgtatattaagtatgcattcttttggatttggggattc gctatcgttatgttagtaattgcaatgttgatgggcattgtgacgatt 317. atggaaaacacggttaaatatcgtaagtttatactccctatcgttgtaggtctccttatt tgggcacttacaccttttaaaccggatgctgtggatccaacagcatggtatatgttcgca atattcgtcgcgacaatcattgcttgtattacacaaccgatgccaattggggccgtctct ataattggatttacaatcatggtactcgttggcattgttgacatgaaaacggctgtcgct ggttttggtaataatagcatttggttaattgctatggcatttttcatttcgagaggattt gtgaaaacaggtcttggtagacgtatcgcacttcatttcgtcaaattatttggtaaaaaa acattaggattagcatattctatcgtcggtgtagatttaattctagcgcctgctacacca agtaataccgcgcgtgctggtggaatcatgttcccaattatcaaatcactttctgaatca tttggttcgaaaccgaaagacggatcagcacgcaaaatgggtgcatttcttgttttcaca gaattccaaggtaatttaattactgcggctatgtttttaactgcaatggccggtaacccc cttgcacaaaatttagcatctagcacatctaat gttcacattacatggatgaattggttt ctagctgctttagttcctggacttgtttccttaattgttgtaccttttattatttataaa atttatccaccaactgttaaagaaacaccaaatgctaagagttgggctgaaaatgaatta gcgactatgggtaaaatcgctttagctgaaaaatttatgattggtatttttgtcgttgcg ttaacactatggattgtcggaagtttcattcatattgatgcaactttaacggcctttatt gcgctagcattgttattattgacaggcgtcttaacatggcaagacattttaaacgaaaca ggtgcttggaacacattagtatggttctcagtattagtgttaatggccgaccaattaaac aagcttggatttattccttggttaagtaaatccattgctacaagtcttggtggcttaagc tggcctatagtcctggtcattttaatattgttctacttctattcacattacttatttgca agttctacagcacatatcagtgcgatgtatgcagcattactaggcgttgccatcgcagcc ggtgcaccaccattattcagtgcattaatgttaggtttcttcggtaacctattagcttca acaacacactatagtagtggtccagcgccgattctattctcttcaggttacgtgactcaa aaacgttggtggacaatgaacttaatattaggtttcgtctactttattatctggattggt ttaggatcactttggatgaaagtaattggtatattt 318. atgaataaagtaattaaaatgcttgttgttacgcttgctttcctacttgttttagcagga tgtagtgggaattcaaataaacaatcatctgataacaaagataaggaaacaacttcaatt aaacatgcaatgggtacaactgaaattaaagggaaaccaaagcgtgttgttacgctatat caaggtgccactgac gtcgctgtatctttaggtgttaaacctgtaggtgctgtagaatca tggacacaaaaaccgaaattcgaatacataaaaaatgatttaaaagatactaagattgta ggtcaagaacctgcacctaacttagaggaaatctctaaattaaaaccggacttaattgtc gcgtcaaaagttagaaatgaaaaagtttacgatcaattatctaaaatcgcaccaacagtt tctactgatacagttttcaaattcaaagatacaactaagttaatggggaaagctttaggg aaagaaaaagaagctgaagatttacttaaaaagtacgatgataaagtagctgcattccaa aaagatgcaaaagcaaagtataaagatgcatggccattgaaagcttcagttgttaacttc cgtgctgatcatacaagaatttatgctggtggatatgctggtgaaatcttaaatgattta ggattcaaacgtaataaagacttacaaaaacaagttgataatggtaaagatattatccaa cttacatctaaagaaagcattccattaatgaacgctgatcatatttttgtagtaaaatca gatccaaatgcgaaagatgctgcattagttaaaaagactgaaagcgaatggacttcaagt aaagagtggaaaaatttagacgcagttaaaaacaaccaagtatctgatgatttagatgaa atcacttggaacttagctggcggatataaatcttcattaaaacttattgacgatttatat gaaaagttaaatattgaaaaacaatcaaaa 319. atgattaatcagtctatatggcgcagtaactttcgcattttatggctcagtcagtttata gcgattgctggactgacagtacttgtgccattattgccaatttatatggcatcactacaa aatctatcagtcgtagaaatacagttgtggagtggtatagcgattgctgctccagctgta acg acgatgatagcttcgccgatatgggggaagctaggtgataagatcagccgaaaatgg atggtgttaagagcgttacttggtttggcggtatgcttatttttaatggcattgtgtacg acaccattacagtttgtacttgtgaggttattgcagggactatttggtggtgttgttgat gcatcaagtgcgtttgcgagtgcagaggcgccagctgaagatcgtggaaaggtattagga agactgcaaagttcagtcagcgcagggtctcttgtggggccattaattggcggtgttaca gcttcgatattaggttttagtgcgttactgatgagtattgccgttattacttttattgtc tgtattttcggtgcattaaaattgattgaaacgacacatatgccaaaatcacaaacacca aatattaataaaggtattcgccgttcatttcaatgtctattatgcacacaacaaacatgt cgatttattatcgttggcgttttagcaaactttgctatgtatggcatgctaactgcatta tcaccacttgcttcatcagtgaatcatacagcgatagatgaccgtagtgtgattggattt ttacagtccgcattttggacggcttcgatattaagcgcgcctttatggggacgctttaat gataaatcatatgttaaatcagtatatatatttgccacgattgcatgtggttgtagtgcg atactgcaaggtttagcgacgaatatagagtttttaatggctgcaagaatacttcaagga ttaacatatagtgcattgattcaaagtgtcatgtttgttgtcgtgaatgcgtgtcatcaa caacttaaaggcacatttgttggaacgacgaacagtatgttagttgttggtcaaattatt ggcagtcttagtggcgctgccattacaagttatactacaccagctactacgtttatcgtt atgggcgtagtatttgcagtaagtagt ttatttttaatttgttcaaccatcactaatcaa atcaacgatcacacattaatgaaattatgggagttgaaacaaaaaagtgcaaaa 320. atgaagcgattattcgatgtagtgagttcaatatatggtttagtagttttaagtccgatt ctgttaattacagcattactaattaaaatggaatcacctggaccagccattttcaaacaa aaaagaccgacgattaataatgaattgtttaatatttataagtttagatcaatgaaaata gacacacctaatgttgcaactgatttaatggattcaacatcgtatataacaaagacaggg aaggtcattcgtaagacctctattgatgaattgccacaattattgaatgttttaaaagga gaaatgtcaattgtaggtcctagaccagcgctttataatcaatacgaattaatcgaaaaa cgtacaaaagcgaacgtgcatacgattagaccaggtgtgacaggactagctcaagtgatg gggagagatgatatcactgatgatcaaaaagtagcgtatgatcattattacttaacacat caatctatgatgcttgatatgtatatcatatataaaacaattaaaaatatcgttacttca gaaggtgtgcatcac 321. atggcacaacttaattcaaagatagcttccttaaaattattcgcaagttacgccatagca acttatattttagttatattaacgagtgcattaaatctttttaaaggttatgtggccgat acgttctatattgctgaaacattgctaatcgttttaaccatcattttaattattatttta acaacggaacaaacatggaagcatcatgacctatggcgacgtatcgtcgaagtgttgtta ttgttgatgacattaacaggcaacgtatttacattattaatgtttgtaagtattagacgt taccaacgtacatcgcaaatacatagttata acgggtgggaatcgtttatacgaaaaact actagacatcgtattgcgattatcgggttacttattttagtctacatgctgacattatca attgtgtcacaatttacatttgatacgacattggctactaaaaatcagttcaatgcactg ttacatggaccgagtctagcctatccgtttggtactgatgatttcggtagagacttattt acacgcgtagttgtaggaacgaagctgacattttcaatttcaattatttcagtagttatt gcagttatttttggtgtgttactaggcactatcgcaggttattttaatcatattgataat ttaataatgcgaattttagatgtagtgtttgcaattccatcattattgttagcggtggca attattgcatcatttggagcaagtattccaaatttaattattgctttaagtatcggtaat ataccatcatttgcacggacaatgcgtgccagtgttttagaaattaaacgcatggaatat gtagatgcagcacgtatcactggtgaaaacacttggaatatcatatggcgttatatttta ccgaatgcgattgcgcctatgattgtacgtttttcattaaatataggtgtggttgtatta acaacaagtagtttaagtttcctaggacttggtgttgcacctgatgtagctgaatggggc aacattttacgtaccggtagtaactacttggaaacgcacagtaatttagctattgtacct ggtgtttgtattatgttcgtcgttttagcatttaattttataggtgatgcagtgcgtgat gcactagatccaagaattcat 322. atgaaaacaatacatttgtttcgcatctaccactcttttttattgaaaaagtggtatttg attatctatttactatttatattagcggcactccttattacattaacgacaatccaacat gtaacagaagatgacaatcattttaata taggtgtcgtagataaagatcaatcaagtgaa acgaaattaatcttaaactctattggtaaagggagtaacctaggaaaaaacgtgagcatt aaagcatatgatgataagcaagcacatactttgttaaaaaaacataaacttcaaggctat tttgtttttgataaaggtatgaccaaggcattttataaacaaggcgaactaccaatttca gtatatacatatgatcaacaatccatgaaaagtgtcgtgctatctcagctaacagattct gtttaccaacgtcttatgcgatcaatgggtggcatcttagcttttcaagacttagcaccg aaagcatcacattctgacagtatcaatgttatgactgatttgctgattacaggattaaac cgttcaggtgcatttaacttagaaccgattcatttatacgatacgggcagttattatgca attacaggatttttaacaacggtattcatctttgcactatctttatttacagttttgaaa atgaatcaagatactgtattgaaagcgcgattgaaaatgtttcatttttctaaagagcgt ttattaatcattcgtacgttgattacatggttttatactatgttatggagtatcgttggt gtagtttggattgtgttcagtattccgaatatctttgaattatataattggccaacgtta gccattcatttaagctattatgttacctttttaatactgtggttattactcatcgaactt ttaacaacaggcttgttgaatagtattagtaaagtcatattagctattgtcatcctggtg ttatctggtttaacaatacctacgatttttttacaacatatagcaaatggtgttttcaat attcaaccgttcgcagttgtaacaaatcaattgttagaaattattttaaacaactacatt ttagaactgcaccctagtttctatcttagcttcatcgcacttttgataatta atttagct gtattggtttggaggtatcgtcaa 323. ttgaaaaaacaagttattatttcgggcctcatgttattttcactattttttggagccgga aatttaatattcccgcccatgcttggccatacagcgggtcaaaatatgtggattggtatg ctaggctttgcccttacaggcatattactcccctttattactgttattgttgttgcattt tatgatgaaggtgttgaaagtgtaggcaatcgtatacatccatggttcgggtttattttt gctgtcgtgatttacatgtctatcggagcattttacggtattccacgtgctgcaaatgtc gcgtacgaaattggtacaagacacattttacctgtgcataaccaatggactttaattata ttcgcagcaatcttttttgccatcgtttactggattagtttaaatccatcgaaaatcgtt gataatttaggtaaattattaacaccgttattactattaatggtcgctctattaagtatt gctgtcattttcaaccctgaatctgcactaagtgcacctaaggataaatatataacacat cctttcatttcaggaagtttggaaggctattttacaatggatcttgttgctgcgttagct ttttccgtagtcattgtcaatggctataagtttaaaggcctcacagatcgcatgaaaatt ttaaaatatgtctgcttttcaggtcttattgcagccatattacttggaatgatttacttt gcacttgcatacgttggggcatcaacagctccaggaaactttaaagatggtacagatata ttgacgtacaactcattacgattatttggttcgttcggtaacctcgtatttggaatgacg gttatccttgcatgcctaacaacatgtataggactcgtcaatgcttgcgccacatttact aagaaacacgtacctaagttttcttataaaatattcgcacttattt tctctatcataggg ttcttatttacaacacttggtttagaaatgattttaaaaattgctgtcccattattgact ttaatatatcccgtgtcgattgcacttgtactcatatcatttgctaacatgtttagcaca ttcagattcagttgggcctatcgactcgcaactgttattacattgattatttcaatttta caaatactaaatagtttcaacttattacacggtgttattttgaaatcgtttatgatgtta cctttagcagatatcgatttagcttggcttgtaccattcatgctctttgctattatcggt ttcataatcgatgtatttatacgccgtccgaaacaagcgacaact 324. gtgaaacattatttgactaaatttgtagcaatgctaataactgctgctatggtgtgtagc tttgggttactgaaaagtcaggcagcagaacaacaaagtattagtgatgtatatagtgtg ataacggatgcgaaatctgcactttctaataattcgatatcgaatgacaataagcagaaa gcaattgagcaagtggtaagtgcagttaagaaattatcgcttgaagataatagtgaaagt aatgctgtcaaatcagatgtgagaaagcttgaagatgcaaaagcgaatgataatcaaaaa gatacactttcgcaattaacgaagtcattaattgcttatgaagagaaattggctagtaaa gatgcgggttctaaaattaaactattgcaacagcaagtcgatgctaaagatgctgcgatg acaaaagcgattaaagataaaaataaagcggaattagaatctttgaacaatagtttgaat cagatttggacaagtaatgaaacagtgattcgcaattatgacgcaaatcaatatggacaa attgaagtcgcattattacaacttagaattgcaattcataagtcaccattagatacggca aaagtgtcacatgcttgga caacttttaaatcaaatattgatcatgtcgataaaaaaagt aatacgtctgcaaatgatcaataccatgtatcacaattaaatgatgcgttagagaaggcg attaaagctatcgacgacaatcaattgtcggatgctgatgctgcgcttacacattttata gaaacttggccgtatgttgaaggtcaaattcaaactaaagacggtgctttgtatacgaaa attgaagataaaataccatattatcaaagtgtattagacgaacataataaagcacatgtg aaagatggtttagtagatttaaataaccaaattaaagaggttgttggccatagttatagc ttcgtcgatgtgatgattatctttttacgtgaagggctagaagtgttgttaattgtaatg acattgactaccatgacgcgtaatgtaaaagataagaaagggactgcaagtgtgattggt ggtgcaattgccggacttgtactgagtattatcttagcaattacgtttgtagaaacttta gggaatagtggcattcttcgtgaaagtatggaagcgggattaggtatcgttgcggtcata ttaatgtttatcgttggtgtttggatgcacaaacgttcaaatgcaaaacgttggaatgac atgattaaaaatatgtatgctaatgcgattagtaatggtaatttggtattgttagcgacg attggtttaatatctgtgttgcgtgaaggtgtcgaggttatcattttctatatggggatg ataggtgagctagcgaccaaagattttattattggtattgctttagctatcgttatttta atcatctttgcattattatttagatttatagttaaattaatacctattttctatatattt agagtgttgtcgatctttatttttattatgggattcaaaatgcttggcgtaagtattcaa aagttacaattattaggtgcgatgccaagacatgttattgaag 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kpkfeyikndlkdtkivgqepapnleeisklkpdliv askvrnekvydqlskiaptvstdtvfkfkdttklmgkalgkekeaedllkkyddkvaafq kdakakykdawplkasvvnfradhtriyaggyageilndlgfkrnkdlqkqvdngkdiiq ltskesiplmnadhifvvksdpnakdaalvkktesewtsskewknldavknnqvsddlde itwnlaggyksslkliddlyeklniekqsk 347. minqsiwrsnfrilwlsqfiaiagltvlvpllpiymaslqnlsvveiqlwsgiaiaapav ttmiaspiwgklgdkisrkwmvlrallglavclflmalcttplqfvlvrllqglfggvvd assafasaeapaedrgkvlgrlqssvsagslvgpliggvtasilgfsallmsiavitfiv cifgalklietthmpksqtpninkgirrsfqcllctqqtcrfiivgvlanfamygmltal splassvnhtaiddrsvigflqsafwtasilsaplwgrfndksyvksvyifatiacgcsa ilqglatnieflmaarilqgltysaliqsvmfvvvnachqqlkgtfvgttnsmlvvgqii gslsgaaitsyttpattfivmgvvfavsslflicstitnqindhtlmklwelkqksak 348. mkrlfdvvssiyglvvlspillitallikmespgpaifkqkrptinnelfniykfrsmki dtpnvatdlmdstsyitktgkvirktsidelpqllnvlkgemsivgprpalynqyeliek rtkanvhtirpgvtglaqvmgrdditddqkvaydhyylthqsmmldmyiiyktiknivts egvhh 349. maqlnskiaslklfasyaiatyilviltsalnlfkgyvadtfyiaetllivltiiliiil tteqtwkhhdlwrrivevllllmtltgnvftllmfvsirryqrtsqihsyngwesfir kt trhriaiigllilvymltlsivsqftfdttlatknqfnallhgpslaypfgtddfgrdlf trvvvgtkltfsisiisvviavifgvllgtiagyfnhidnlimrildvvfaipslllava iiasfgasipnliialsignipsfartmrasvleikrmeyvdaaritgentwniiwryil pnaiapmivrfslnigvvvlttsslsflglgvapdvaewgnilrtgsnylethsnlaivp gvcimfvvlafnfigdavrdaldprih 350. mktihlfriyhsfllkkwyliiyllfilaallitlttiqhvteddnhfnigvvdkdqsse tklilnsigkgsnlgknvsikayddkqahtllkkhklqgyfvfdkgmtkafykqgelpis vytydqqsmksvvlsqltdsvyqrlmrsmggilafqdlapkashsdsinvmtdllitgln rsgafnlepihlydtgsyyaitgflttvfifalslftvlkmnqdtvlkarlkmfhfsker lliirtlitwfytmlwsivgvvwivfsipnifelynwptlaihlsyyvtflilwllliel lttgllnsiskvilaivilvlsgltiptiflqhiangvfniqpfavvtnqlleiilnnyi lelhpsfylsfialliinlavlvwryrq 351. mkkqviisglmlfslffgagnlifppmlghtagqnmwigmlgfaltgillpfitvivvaf ydegvesvgnrihpwfgfifavviymsigafygipraanvayeigtrhilpvhnqwtlii faaiffaivywislnpskivdnlgklltpllllmvallsiavifnpesalsapkdkyith pfisgslegyftmdlvaalafsvvivngykfkgltdrmkilkyvcfsgliaaillgmiyf alayvgastapgnfkdgtdiltynslrlfgsfgnlvfgmtvilaclttciglvnacatft kkhvpkfsykifali fsiigflfttlglemilkiavplltliypvsialvlisfanmfst frfswayrlatvitliisilqilnsfnllhgvilksfmmlpladidlawlvpfmlfaiig fiidvfirrpkqatt 352. mkhyltkfvamlitaamvcsfgllksqaaeqqsisdvysvitdaksalsnnsisndnkqk aieqvvsavkklslednsesnavksdvrkledakandnqkdtlsqltksliayeeklask dagskikllqqqvdakdaamtkaikdknkaeleslnnslnqiwtsnetvirnydanqygq ievallqlriaihkspldtakvshawttfksnidhvdkksntsandqyhvsqlndaleka ikaiddnqlsdadaalthfietwpyvegqiqtkdgalytkiedkipyyqsvldehnkahv kdglvdlnnqikevvghsysfvdvmiiflreglevllivmtlttmtrnvkdkkgtasvig gaiaglvlsiilaitfvetlgnsgilresmeaglgivavilmfivgvwmhkrsnakrwnd miknmyanaisngnlvllatiglisvlregveviifymgmigelatkdfiigialaivil iifallfrfivklipifyifrvlsififimgfkmlgvsiqklqllgamprhviegfptin wlgfypsyepliaqgayimvvailifkfkk 353. atgaagaatttttctaaattcgcacttacaagtattgccgcattaactgtggcaagtcct ttagtcaatacggaggttgacgctaaggataaagtatcagcaactcaaaacatcgatgcg aaagtaacccaagaatctcaagcaactaacgcattgaaagagttaccaaaatctgaaaat ataaaaaagcattacaaagattataaggtcactgatactgaaaaagataacaaaggattt acgcattacacattgcaaccgaaagtgggcaacacgtatgcac cagacaaagaagtaaaa gttcatacgaataaagagggtaaggtagttcttgtcaatggtgatactgatgctaagaaa gttcaacctacgaataaggtagcgataagtaaagaaagtgccacagataaagctttcgaa gcaataaaaattgaccgtcaaaaagctaaaaacttaaaaagtgatgtcatcaaaaccaat aaagttgagattgatggagaaaaaaataaatatgtttataacatagaaattattacaact tcaccaaaaatctctcattggaatgtgaaaattgacgctgaaactggtcaagtggttgat aaattaaatatgatcaaagaagcagctactacaggtacaggtaaaggtgtactaggtgac acgaaacaaattaatattaatagtgtcagcggtggttatacactacaagatttaactcaa caaggtacactttcagcttacaattacgatgcgaatactggtcaagcttacttaatgcaa gataaagataaaaattttgttgatgatgaacaacgtgcaggtgtagatgcaaattattat gctaaagaaacgtatgactattataaaaatactttcggccgagaatcatatgataatcaa ggtagcccaattatttcaatcgcacatgtaaataacttccaaggtcaagataacagaaac aatgcagcttggattggtgataaaatgatttacggtgacggtgatggacgtacatttaca gcgttgtctggtgcgaatgatgttgttgcacatgaaattacacatggtgtaacacagcaa actgctaatcttgtttaccgttctcaatcaggtgcattaaatgaaagtttttcagatgta tttggttacttcattgatgatgaagatttcttaatgggtgaagatgtttacacacctggt gtaggcggagatgccttaagaagtatgtctaatccagagcgttttggacaaccatctcat atgaat gattttgtttatacaaattctgacaacggaggcgtacatacgaattcaggtatt ccgaacaaagcagcttacaacacaattcgtagtattggtaaacaacgttctgaacaaatt tattatagagcgttaactgtttatttaacttcaaattctgatttccaagatgccaaagca tcattacaacaagcagcatttgatttatatggcgacggtattgctcaacaagtaggtcaa gcatgggacagtgttggcgtg 354. atgtctaaacatagtgctacgttagttattatgtttttaataactttattgcctattttt caatatcaagcttctgcacatgcgactttagaaaaatcaacaccacaacagcaaggggtt attaaagacaaaccagaagcaatcaagttagagtttaatgaacctgtgaacaccaaatac tcgagtgtgaccttatttgatgataaaggtaaaaagattaaagaccttaaaccaataaca actggatggtctcagacagttgtattttcatctgagcaaattgttaatggcacgaatact attgaatggcatacggtatctgcggatggacatgaagtcggagatacgtttgaattttca gttggaaaagtgaggctaaagatg 355. atgaaaaaaatcaaaacaatctcgacattggtagctggacttggtatagcatttctaggt cacacaacacatgcagatgcggctgaaaataacaatcaacaacaaagtacatataactat agtacaactgaagtatcattttctaattcaggaaatttatatacttctggccaatgtact tggtatgtttatgataaaactggtggaaaaatcggatcaacatgggggaatgcaaatagc tgggcaactgcagctcaagcagcaggattcactgtaaataatacacctgaagaaggtgca attatgcaatcatctgaaggtgctttcggacatg ttgctttcgttgaaagtgtcaataat gatggttctattactgtatcagaaatgaactatgatggtggtccattcgctataagcaca cgaacaatctctgccagtgaagcaagttcatataattacatccacctgaat 356. atgaaaaaaatcgctacagctacaattgcaactgcaggaatcgctactttcgcatttgca caccatgacgcacaagcagcagaacaaaataatgatgggtacaatccaaacgacccttat tcatatagctacacttacacaatcgatgctgaaggtaactaccactacacttggaaaggt aactggagtccagatcgtgtaaatacttcatataactataataattataataactacaac tactatggttacaataactatagcaactacaataactacagtaattacaacaattacaac aactatcaatcaaacaacacgcaatcacaaagaacaactcaaccgactggtggtttaggc gcaagctattcaacatcaagtagtaatgttcacgttacaacaacttctgcgccatcatca aacggtgtatctttatcaaacgctcgctcagcatctggtaacttatacacttcaggtcaa tgtacatattatgtatttgacagagtaggtggcaaaatcggttcaacgtggggtaacgca aacaactgggcaaacgctgcagcacgttctggttacacagtaaacaattcacctgctaaa ggtgcaatcttacaaacgtcacaaggtgcatacggacacgtagcatacgttgaaggtgta aacagcaatggttcaatcagagtttcagaaatgaactacggtcacggtgcaggtgttgtc acttcacgtacaatctctgcgagtcaagctgcttcatataactatattcac 357. ttggaagataaaaaagctccagtaaatgaagactttttaaattacatcaaaaactatgcc gatgt aagaaacatacctctttcaagacgtaagatggcctcgttgtttcacacttctaaa actgcaattgatgatgtctcacaagaaaaactaaatacttggttacgaaaacctgataag ttttacgtgaatattatcgagctttcgaaagacttatattacaagtctggtgaatatcgt agcttacttaattactttattgatatggctcgtttctattatgtgattgatccattgttt agcagcgatagtaagatgagcaaggagaaagtcaaaaaagacctctctaaaatatcttta caacttaataaaatgaatttaaaacatgagttagctaaaatttacaaaacatgtgtactt gaagatattttctttggttatgaaatcgaagataaagacaattacttcatgttaaaactt gatccaaagtattgtaaattagttggtatctctgacgggatgtatacatatgctttcaac ctgtcctattttgacggtaatttagatttattaaaaacattcccagaagagtttcaaaga gcatatttagaacgctctattgataagcaagctgacttaaattggtttattccagacttc actaaatcagttgttttcaaaattaatgaagacgatcctactattttacctccattttct acaatgtttgaacccctattagatttaaacgattataaaaagcttaaaaaagctggagct aaaattaataactacatgttattacatcaaaaagtgccaatgcatgataatgcaaataaa gattatcaagctgataacttcgcaatctcagctgaggcaatggactacttcagcgagtta gttaacgaaaacttaccagatgaaattggttctatcgtttcccctatggaagttaaccct attaaattagatagagatgataaaactgataaggtacttgaagctactagagatgtttat aacgcttctggtgtttcttcatttatctt taacaatgataaaaactctactggtggttta acttactcagttcgtaaagatgagttattcgtaattaatttctaccgacaagttgagaga tggttaaatcgtaaaatcagatatggcaatatcgtagccaaaaatcaatggagaatttct ctattaaatgtaactggaatgagtgaagatacttacttagagcaattaactaagtctggt acattcggtttctcagttagaggacgtattgctgcattacatggtttagattaccataca ttatctcaaagtttagaattagaaaacaatatcttagatttagatactaatttaatacct cttgctagttctcatactggtggtttaaatactgctgttgaacaaacaaaaggaaaaata gaagactctggtggcagacctactaaagaaactaaagacttgtctgatagcggacaagca aatcgtgactctagtaattctgagacaaaatctttagaaggtggtgacactaataatgaa 358. gtgggagtcgtgtcaatcattactgggattacaatatttgtcagtggtcagcatgctcaa gctgctgaaatgacacaatcatcatcagattctaacgaacagtcacaacaaacagaacaa gttgaacacaaagaagatacaactcatttatcttacgaattgaatcaagagggtgagaca gcgagccaatcaaagactagtcaagagaatcaatctgatggcaatgtacaaaaaaagagt aatcaaatacaacaagattcaacacaaacgtcaccattaaatgaccaaaaacaaacttca atggaacaacaatcaaaagacaatcatgttaccccaaattcacgtcaggatacatatcca aaaggccaaaatcaagatgataaaggcaaacaacagtttaaagataatcaacactcacaa acagaacatcaacctaatactcaaaaccaaaataatgatcaagattca tcagataaaaag caacacccatctgatcaaactcaagactcatcttcaaaaggaacacaacctaaacaatca cagtctatagaagatagagataaaacagtaaaacaaccatcttctaaagtacacaaaata ggtaacacaaaaactgataaaacagttaaaacaaatcaaaaaaagcaaacatcattaact tcaccacgcgttgtgaaatcaaaacaaactaaacatatcaatcaacttactgcgcaagct caatataaaaatcaatatccagtcgtgtttgtacatggatttgtaggtttagtcggtgaa gatgcattcagcatgtacccaaattattggggtggtactaaatataacgtgaaacaagaa cttacaaaattaggttaccgagttcacgaagccaatgtaggggcatttagcagcaattat gaccgtgctgttgaactgtattattatattaaaggtggaagagtagattatggtgcagca catgctgcaaaatatggtcacaagcgttatggcagaacatatgaaggcatcatgcctgat tgggaaccaggtaaaaagatacatcttgttggacatagtatgggtggccaaacgatacgc ttgatggaacattttttaagaaatggaaatcaagaagaaatagattatcaacgtcaatat ggtggtacggtatccgatttatttaaaggtggacaagataatatggtgtctacgattact acattaggaacgcctcataatggcacacctgctgcagataaactagggtcgactaaattt attaaagatacaattaatagaattggaaaaattggtggaactaaagcgctcgatttagaa ctaggtttttctcaatggggcttcaaacagcaacctaatgaatcatatgctgaatatgca aaacgtatagcgaatagtaaagtttgggagactgaagatcaggctgtaaatgatttaaca actgctggagc agaaaagttaaaccaaatgacgacattgaatcctaatatcgtctataca tcatatacaggtgctgcaacacatactggaccattaggcaatgaagtgccgaatattaga caattcccactattcgatttaacaagtcgtgtgataggtggagatgataataaaaatgtc agagtaaatgatggcatagtacctgtgtcttcttcactacatccaagtgatgaagcattt aagaaggtaggtatgatgaacctagcaactgacaagggtatctggcaagtgagacccgta caatatgattgggatcatctagatttagtcggcttagatactactgattataagcgaact ggagaagaattaggtcaattctatatgagtatgataaataatatgttgaaagtcgaagag ttagatggtattacacgtaag 359. mknfskfaltsiaaltvasplvntevdakdkvsatqnidakvtqesqatnalkelpksen ikkhykdykvtdtekdnkgfthytlqpkvgntyapdkevkvhtnkegkvvlvngdtdakk vqptnkvaiskesatdkafeaikidrqkaknlksdviktnkveidgeknkyvynieiitt spkishwnvkidaetgqvvdklnmikeaattgtgkgvlgdtkqininsvsggytlqdltq qgtlsaynydantgqaylmqdkdknfvddeqragvdanyyaketydyykntfgresydnq gspiisiahvnnfqgqdnrnnaawigdkmiygdgdgrtftalsgandvvaheithgvtqq tanlvyrsqsgalnesfsdvfgyfiddedflmgedvytpgvggdalrsmsnperfgqpsh mndfvytnsdnggvhtnsgipnkaayntirsigkqrseqiyyraltvyltsnsdfqdaka slqqaafdlygdgiaqqvgqawdsvgv 360. mskhsatlvimflitllpifqyqasahatlekstpq qqgvikdkpeaiklefnepvntky ssvtlfddkgkkikdlkpittgwsqtvvfsseqivngtntiewhtvsadghevgdtfefs vgkvrlkm 361. mkkiktistlvaglgiaflghtthadaaennnqqqstynysttevsfsnsgnlytsgqct wyvydktggkigstwgnanswataaqaagftvnntpeegaimqssegafghvafvesvnn dgsitvsemnydggpfaistrtisaseassynyihln 362. mkkiatatiatagiatfafahhdaqaaeqnndgynpndpysysytytidaegnyhytwkg nwspdrvntsynynnynnynyygynnysnynnysnynnynnyqsnntqsqrttqptgglg asystsssnvhvtttsapssngvslsnarsasgnlytsgqctyyvfdrvggkigstwgna nnwanaaarsgytvnnspakgailqtsqgayghvayvegvnsngsirvsemnyghgagvv tsrtisasqaasynyih 363. ledkkapvnedflnyiknyadvrniplsrrkmaslfhtsktaiddvsqeklntwlrkpdk fyvniielskdlyyksgeyrsllnyfidmarfyyvidplfssdskmskekvkkdlskisl qlnkmnlkhelakiyktcvlediffgyeiedkdnyfmlkldpkycklvgisdgmytyafn lsyfdgnldllktfpeefqraylersidkqadlnwfipdftksvvfkineddptilppfs tmfeplldlndykklkkagakinnymllhqkvpmhdnankdyqadnfaisaeamdyfsel vnenlpdeigsivspmevnpikldrddktdkvleatrdvynasgvssfifnndknstggl tysvrkdelfvinfyrqverwlnrkirygnivaknqwrisllnvtgmsedtyleqltksg tfgfsvrgriaalhgldyhtlsqslelennildldtnlipl asshtgglntaveqtkgki edsggrptketkdlsdsgqanrdssnsetksleggdtnne 364. vgvvsiitgitifvsgqhaqaaemtqsssdsneqsqqteqvehkedtthlsyelnqeget asqsktsqenqsdgnvqkksnqiqqdstqtsplndqkqtsmeqqskdnhvtpnsrqdtyp kgqnqddkgkqqfkdnqhsqtehqpntqnqnndqdssdkkqhpsdqtqdssskgtqpkqs qsiedrdktvkqpsskvhkigntktdktvktnqkkqtsltsprvvkskqtkhinqltaqa qyknqypvvfvhgfvglvgedafsmypnywggtkynvkqeltklgyrvheanvgafssny dravelyyyikggrvdygaahaakyghkrygrtyegimpdwepgkkihlvghsmggqtir lmehflrngnqeeidyqrqyggtvsdlfkggqdnmvstittlgtphngtpaadklgstkf ikdtinrigkiggtkaldlelgfsqwgfkqqpnesyaeyakrianskvwetedqavndlt tagaeklnqmttlnpnivytsytgaathtgplgnevpnirqfplfdltsrviggddnknv rvndgivpvssslhpsdeafkkvgmmnlatdkgiwqvrpvqydwdhldlvgldttdykrt geelgqfymsminnmlkveeldgitrk 365. tcaataaggtgctttctaaagaatttttctccccatgtccaatctataaataaatctttg gttaaaaattgcgacacaaccattctcattcgattatgcataaaaccagtttgtgtcaat tccattattgctgcatcaatgattggaaatcctgtttgcccttcgcaccatgcattaaaa tccgcttcattttgcgaccattttatctgtcgatatttaggtttgaaagcttggtatgag gtttcaggatactgtgtcattaacacataa 366. ctgttgcacca tttggtccttttgcacctaagtcaattgatacttgcccagttgccatat caggaattaacattggtacgaaaaatggactcacacgtcttgggcctttatccattaatt gtttatgtgcaatttcaaatgtttccataccaccgataccagaaccaatccatacaccga ttcgatctgcagtattttcat 367. gatgcacctttaggtctaatacctggtgttacttttaaaaatgatgtacctaacttttca gtcaacatacgactttcaagaggtgaacaaacaacgccatctaaaccagctgcatttgct aacttggcataa 368. tacatcaaaccactatgtttacccattttcttaccatcaagtgttatcatatcacccggt tgtgcaggtaaatattgtgataaaaatgttttaaagtttttttcgccgataaaacaaatg cctgtagaatcttttttcttagcagtaacaagtccttgttcttcagcaattcgacgcact tcactcttttcgatgtcgccaattgggaacatcacttttgaaagttgttgt 369. cgtttcgcatcttcatcatattctaataatggccaatctgtcacccataagaagtttaat tttgtttcatcgattaaacctaattctttagctaatttgacacgtaatgcacctaaactt tgtgcaacgacatttggtttgtctgcaacaaacattactaagtcaccagcttcagcacca gttaatgtaagtaatgtttcaacattttctgtttcaaagaaacgtccaattggacctgtc aaaccatcttccacaactttaacccacgctaatcctttagcacca 370. cgtcaacgtcctgtccatgtgtttccaaaaaataataatccacatgggcaatataatcat caatatcaacatcactacgtaacgctagcaaatgctttt 371. atgaatgaagcatctaattt aatcttaaccatgccaaatgaatccaaagccgcaactaaa atagcaaagattaagccgccaatcactggtgctggtatacaaatacgttttaaaaaatta acg 372. attctatcagccgcattatccacaccggcattattaaacaacacatcgattcttccaaac tgttcctttatgtcagacacaaagtctaccacttgttgttcgcttgcattatccacatta tacgccttcgcattgtcaccattacttttaattttatcgacagtctccgataccgcttca gctatgtctaccgccaatacatacgcaccttat 373. cctggcgctattgtttcaggtccgtattctgttaattcattaatcggatcttttgtaatc tcttcttttggttcacctttactaataattactccagttaatggattttttagtgttggt gtcgttattgtcttctcacctttttgtccttctcttgttactttttctgtccctggtgct aaatccggattaaatttacgttctttcttgaatggaatctcttcaacttttttttctaat tctgttattgtttttggcgcttctggtgtaaaagtaaactctgaacctttcaagtcagtt ctcatccagccatttgcatttatccct 374. ttactaacatttattgctgttaaacctacgatgacaaataaaataatagctaatactttt aaaataactaaaatattttccatacgagctgcttccgacataccacgtgatagtaataat gcagttaataaaataacgatagcagcaataatatcgataaaaccgccatttgtaccaaat ggatttgataatgctgcaggtaattcgatgccaattggtttcacaagtccgcgtaaattc gctgagaatcctgatgcaacaaaggctacggcgataaaatattcagctaatagagcccaa ccggcaacccatccaaaaaattca ccaaataatacattgacccaagaa 375. gatgtgttgaaactgagttcaattaaattatatgtttttattatacactttttgacatat tttttaaatttaagaatgcgaagatttttaacatttctgatgctagctttctttttcatc tttcaaatgcttaataaaatcaaagccaggtcgccctttagccaatgcttccatcacatc ataccaatccgaaccgacttgttgatatatattttgcaa 376. tctatcattgtaaatactgtatctaagtgcataaaagttcgactagttggaatttcaatt gctactacttttttaaacgtcgcctgcggattttcaaaaatacgtcgcgctaacttttca atagcttgtgcagatgtacgttctgaaacgcctatagccaagacatctttagataaaaca agttcatcgccgccttcaatattgaatgggcaatctcgatctaaccagattggaatattc gcatctttaaatctagga 377. gaagtcttggccattcccttgagtaaacatgaagccccagccatctgctcctgttgtatt accttggttgttgtttgctactggaacagtaattgtaaagtctttattaaaatctatttt atcattatattctaa 378. sircflknfsphvqsinkslvkncdttilirlcikpvcvnsiiaasmignpvcpshhalk sasfcdhficrylglkawyevsgycvint 379. llhhlvllhlsqlilaqlpyqeltlvrkmdshvlglyplivyvqfqmfpyhryqnqsihr fdlqyfh 380. daplglipgvtfkndvpnfsvnirlsrgeqttpskpaafanla 381. yikplclpiflpssviispgcagkycdknvlkffspikqmpvesfflavtspcssairrt slfsmspignitfescc 382. rfasssysnngqsvthkkfnfvssikpn slanltrnapklcattfglsatnitkspasap vnvsnvstfsvskkrpigpvkpssttlthanplap 383. rqrpvhvfpknnnphgqynhqyqhhyvtlanaf 384. mneasnliltmpneskaatkiakikppitgagiqirfkklt 385. ilsaalstpallnntsilpncsfmsdtksttccslalstlyafalsplllilstvsdtas amstantyapy 386. pgaivsgpysvnsligsfvissfgsplliitpvngffsvgvvivfspfcpslvtfsvpga ksglnlrsflngisstffsnsvivfgasgvkvnsepfksvliqpfafip 387. lltfiavkptmtnkiiantfkitkifsiraasdiprdsnnavnkitiaaiisikppfvpn gfdnaagnsmpigftsprkfaenpdatkataikysanraqpathpknspnntltqe 388. dvlklssiklyvfiihfltyflnlrmrrfltflmlafffifqmlnkikarspfsqcfhhi ipirtdlliyilq 389. siivntvskcikvrlvgisiattflnvacgfskirranfsiacadvrsetpiaktsldkt sssppsilngqsrsnqigifaslnlg 390. evlaiplskheapaicsccitlvvvcywnsnckvfikiyfiiif 391. cgttgcacaaagctgaatgttaaaaatgcggatccgccagcaatgactgcaatccaacaa tctgatgcgacaccaccaaacataaataggaagaagccacatgcaatggcagctgcaaag aaattcgttaaaaaagaatattgtaatgatgcatgctgtaaa 392. rctklnvknadppamtaiqqsdatppninrkkphamaaakkfvkkeycndacck 393. atgactaataaaagagaagatgtccgcaatatagcaattattgctcacgttgaccatggt aaaacaact ttagtagatgagttgttaaaacaatctggtatattcagagaaaatgaacat gtcgatgaacgtgcaatggactctaacgatatcgaaagagagcgtggaattacgattcta gccaaaaatacggctgttgattataaaggtacacgtattaatattttggatacaccagga catgcagactttggtggagaagtagaacgtattatgaaaatggttgatggggttgtctta gtagtagatgcgtatgaaggtacaatgcctcaaacacgttttgtacttaaaaaagcgcta gaacaaaacctgaaacctgttgttgttgttaataaaattgataaaccatcagcacgtcca gagggtgttgtagatgaagttttagatttatttattgaattagaagcaaacgatgaacaa ttagaattccctgttgtttatgcttcagcagtaaatggtacagctagcttagatcctgaa aagcaagatgataatttacaatcattatatgaaacaattattgattatgtaccagctcca attgataacagtgatgagccattacaattccaagtagcattgttggactacaatgattat gttggacgtattggtattggtcgtgtattcagaggtaaaatgcgtgtcggagataatgta tcactaattaaattagacggtacagtgaaaaacttccgtgtaactaaaatctttggttac tttggattaaaacgtttagaaattgaagaagcacaagctggagatttaattgctgtttca ggtatggaagacattaatgttggtgaaactgtaacaccacatgaccatcaagaagcattg ccagttctacgtattgatgagcctactcttgaaatgacatttaaagttaacaattctcca tttgctggccgtgaaggtgactttgtaacagcacgtcaaattcaagaacgtttaaatcaa caattagaaacagatgtatctttgaaagtttct aacacagattctccagatacatgggta gttgctggtcgcggtgaattgcatttatcaatccttattgaaaatatgcgtcgtgaaggt tatgaattacaagtttcaaaaccacaagtaattattaaagaaatagatggtgtaatgtgt gaaccatttgaacgtgtgcaatgtgaagtgccacaagaaaatgcaggtgctgttattgaa tcattaggtgcacgtaaaggtgaaatggttgatatgactacaactgataatggacttaca cgtttaatctttaatgtaccggctcgtggtatgattggttatacgactgaatttatgtca atgacaagaggttacggtattattaaccatacatttgaagaatttagaccacgtattaaa gcacaaattggcggtcgtcgtaatggtgcattaatttcaatggatcaaggttctgcaagt acttatgccattttgggacttgaagatagaggtgtaaacttcatggaacctggtactgaa gtttatgaaggtatgattgttggtgaacataatcgtgaaaatgatttaactgttaacatc actaaaacaaaacatcaaactaacgtacgttctgcaacgaaagaccaaacacaaacaatg aatagaccgcgtattctaacattggaagaagcgttacaattcattaatgatgatgaactt gttgtggttacaccagaaagtatacgtttaagaaagaaaattttaaacaaaaatgttcgt gaaaaagaagcaaagcgtatcaaacaaatgatgcaagaaaacgaa 394. gtgcttaggagtgatttttatatgtcttattccattgttagagtttcaaaagttaaatct ggaacaaatacaacgggcatacaaaaacatgttcaaagagaaaataataattatgaaaat gaagatatagaccatagtaaaacttacttaaattatgatttggtaaatgctaataaacag aatttt aataacttgattgatgaaaaaatcgaacagaattatacaggcaaaagaaaaatt agaacagacgcgattaaacacattgatggtttaattacatcagacaatgatttctttgat aatcaaacgccagaagatacaaagcagttttttgaatatgctaaagagtttttagaacaa gaatacggtaaagataatttattatatgcaacagttcacatggacgaaaaaacaccacat atgcattatggcgttgttccaataactgatgatggtcgtttaagtgctaaagaagttgta ggtaataaaaaagctttaacagcgtttcaagatagatttaatgagcatgttaaacaacga ggatatgatttagaacgtgggcaatcaagacaagtaacaaatgctaaacatgagcaaata agtcagtataaacaaaaaacagaatatcataagcaagaatatgaacgtgagagccaaaaa acagaccatataaagcaaaagaacgataaattaatgcaagagtaccaaaaatcgttaaat acgcttaaaaagcctataaatgttccgtatgagcaagaaactgaaaaagtaggtggttta tttagcaaagaaatacaagaaactggaaatgttgtaataagccaaaaagatttcaatgaa tttcagaaacagataaaagctgctcaagatatttcggaagattacgagtatataaagtct ggtagagccttagatgataaagataaggaaatacgagagaaagatgatttattaaataaa gcagttgagcgtattgaaaacgcagacgataattttaaccaactttacgaaaatgcaaag ccacttaaagagaatatagaaatagcgttaaagcttttaaaaatcttactaaaagagtta gaacgagttttaggaagaaatacctttgcggaaagagttaataagttaacagaagatgaa ccaaaacttaatggtttagcaggaaactta gataaaaaaatgaatccagaattatattca gaacaggaacagcaacaagaacaacaaaagaatcaaaaacgagatagaggtatgcactta 395. mtnkredvrniaiiahvdhgkttlvdellkqsgifrenehvderamdsndierergitil akntavdykgtrinildtpghadfggeverimkmvdgvvlvvdayegtmpqtrfvlkkal eqnlkpvvvvnkidkpsarpegvvdevldlfieleandeqlefpvvyasavngtasldpe kqddnlqslyetiidyvpapidnsdeplqfqvalldyndyvgrigigrvfrgkmrvgdnv slikldgtvknfrvtkifgyfglkrleieeaqagdliavsgmedinvgetvtphdhqeal pvlrideptlemtfkvnnspfagregdfvtarqiqerlnqqletdvslkvsntdspdtwv vagrgelhlsilienmrregyelqvskpqviikeidgvmcepfervqcevpqenagavie slgarkgemvdmtttdngltrlifnvpargmigyttefmsmtrgygiinhtfeefrprik aqiggrrngalismdqgsastyailgledrgvnfmepgtevyegmivgehnrendltvni tktkhqtnvrsatkdqtqtmnrpriltleealqfinddelvvvtpesirlrkkilnknvr ekeakrikqmmqene 396. VLRSDFYMSYSIVRVSKVKSGTNTTGIQKHVQRENNNYENEDIDHSKTYLNYDLVNANKQ NFNNLIDEKIEQNYTGKRKIRTDAIKHIDGLITSDNDFFDNQTPEDTKQFFEYAKEFLEQ EYGKDNLLYATVHMDEKTPHMHYGVVPITDDGRLSAKEVVGNKKALTAFQDRFNEHVKQR GYDLERGQSRQVTNAKHEQISQYKQKTEYHKQEYERESQKTDHIKQKNDKLMQEYQKSLN TLKKPINVPYEQETEKVGGLFSKEIQET GNVVISQKDFNEFQKQIKAAQDISEDYEYIKS GRALDDKDKEIREKDDLLNKAVERIENADDNFNQLYENAKPLKENIEIALKLLKILLKEL ERVLGRNTFAERVNKLTEDEPKLNGLAGNLDKKMNPELYSEQEQQQEQQKNQKRDRGMHL 397. atgactgttgaagaaagatccaatacagccaaagttgacattttaggggtcgattttgat aatacaacaatgttgcaaatggttgaaaatattaaaaccttttttgcaaatcaatcaacg aataatctttttatagtaacagccaaccctgaaatagtgaattacgcgacgacacatcaa gcgtatttagagttaataaatcaagcgagctatattgttgctgatgggacaggagtagtc aaagcttcgcatcgtttaaagcaacctctagcgcatcgtatacctggtattgagttgatg gatgaatgtttgaaaattgctcatgtaaatcatcaaaaagtatttttgctaggggcaact aatgaagttgtagaagcggcacaatatgcattgcaacaaagatatccaaacatatcgttt gcacatcatcacggttatattgatttagaagatgagacagtagtgaaacgaattaaactg tttaaacctgattacatatttgtaggtatgggattccctaaacaagaagaatggattatg acacatgaaaaccaatttgaatctacagtgatgatgggcgtaggtggttctcttgaagta tttgctggggctaaaaagagagcgccttatatctttagaaaattaaacattgaatggata tatagagcattaatagattggaaacgtattggtagattaaagagtattccaatatttatg tataaaatagccaaagcaaaaagaaaaataaaaaaggcgaaa 398. mtveersntakvdilgvdfdnttmlqmveniktffanqstnnlfivtanpeivnyatthq aylelinqasyivadgtgvvkashrlkqplahripgielmdeclkiahvnhqkvfllgat nevveaaqyalqqrypnisfahhhgyidledetvvkriklfkpdyifvgmgfpkqeewim thenqfestvmmgvggslevfagakkrapyifrklniewiyralidwkrigrlksipifm ykiakakrkikkak 399. atgagtgaaaattttaagttacgtaaaatgaaagtcggtttagtatctgttgcaattaca atgttatatattatgacaaacggacaagcagaagcatctgaaaatcaaaacgctttaatc tctaatataaatgtagacaatcaggaaaaacagaataatgtaaatcaagctgttcagcct caaaataatactaatgaaacatcaaaagtaccggctaattttgtcaaattgaatgatatt aaaccaggtgatacttctatacaaggaacaactttaccaaatcaatttatactattaact attgataaaaaagatgtgagctcagttgaagattctgacagcagctttgttatgtctgat aaagatgggaattttaagtatgacttaaatggtcgcaaaattgttcataatcaagaaatt gaagtgtcttcatcagatccctatttaggtgacgatgaagaagatgaagaagtagaagaa acttcaactgaagaagttggtgctgaggaagaaagtacagaagctaaagctacatataca acaccgcgatatgaaaaagcgtatgaaataccgaaagaacagctaaaagaaaaagatgga catcaccaagtttttatcgaacctattactgaaggttcaggtattattaaaggccatacc tctgtaaaaggtaaagttgctctatctattaataataaatttattaactttgagacaaat gctaatggtggtccaaataaagaagaagcgaaatctggatcagaaggaatctggatgcct att gatgacaaaggatactttaattttgacttcaaaacgaaacgtttcgatgatttagag ttaaagaaaaatgatgagatctcattaacatttgcacctgatgacgaagatgaggcattg aagtcattaattttcaaaactaaggtaacgagtttagaagatattgataaagcagaaact aaatatgaccatactaaagtggaaaaagtaaaagtattgaaagatgttaaagaagattta catgtagatgaaatttacggaagcttatatcatacagaaaaaggtaaaggtattcttgat aaagaaggtactaaagtaattaaaggtaagactaaattcgcaaatgcagttgtgaaggta gactctgaactaggtgaaggtcaagaattccctgatttgcaagtcgatgraaaaggtgaa ttcagctttgatgtagatcatgctggatttagattacaaaatggagaaacactaaacttc acagtagttgatcctattacaggtgaattattaagtggaaattttgtttctaaaaacata gatatttatgaatctcctgaagaaaaagcagatcgtgagtttgatgaaagaatggaaaac acacctgcatatcataaattacatggtgataaaattgtcggctacgatactaacggattc ccgattacctggttttatccattaggtgaaaagaaagttgaacgtaaggcaccaaaatta gaaaaa 400. msenfklrkmkvglvsvaitmlyimtngqaeasenqnalisninvdnqekqnnvnqavqp qnntnetskvpanfvklndikpgdtsiqgttlpnqfilltidkkdvssvedsdssfvmsd kdgnfkydlngrkivhnqeievsssdpylgddeedeeveetsteevgaeeesteakatyt tpryekayeipkeqlkekdghhqvfiepitegsgiikghtsvkgkvalsinnkfinfetn anggpnkeeaksgse giwmpiddkgyfnfdfktkrfddlelkkndeisltfapddedeal kslifktkvtsledidkaetkydhtkvekvkvlkdvkedlhvdeiygslyhtekgkgild kegtkvikgktkfanavvkvdselgegqefpdlqvdxkgefsfdvdhagfrlqngetlnf tvvdpitgellsgnfvsknidiyespeekadrefdermentpayhklhgdkivgydtngf pitwfyplgekkverkapklek 401. gtctatatgctatcaagtaccaggtttattgttaggtggtacaacaattgtaataagtcc actaatatcattaatgaaagatcaagtggatcaattaaaagcgatgggaattcaagctgc ttttttaaa 402. vymlsstrfivrwynncnkstniinerssgsiksdgnsscffk 403. tttaaatataaaaaaaacagaaaaatacctagtattatgatgcaacaaattaaaattact atactatattcatatttaacgataaataaatgggaataccttcttaacataacaccaaat aagaccgtacttcctgccactggccaaaaagaattgattttagctgtcttcacaatgttt aaagtttcaaaatctttttcgctgattttgacgtacttttttggaatcagccaattaatc attgggaaaaagagtgctaaccatgtacttactaaatcaatcatcaaatattcatctttg tatttgataattctatatttgggattcttattaatattttcagtttcacaaagcaatgtc tccacttcttttcaattggttttatat 404. fkykknrkipsimmqqikitilysyltinkweyllnitpnktvlpatgqkelilavftmf kvsksfsliltyffgisqliigkksanhvltksiikysslyliilylgfllifsvsqsnv stsfqlvly 405. ggaatgaaaatgatttcgatt tccgatgaaatcaattgtttaatttgttgcaattgtgta gggttatgttcttttatttcttctgctaagtatattttttggatttccatttcttctaac actgtagctaagacatcaataaagcgtggtaagtttttagttacagctaggtcgatacga cga 406. gmkmisisdeincliccncvglcsfissakyifwisissntvaktsikrgkflvtarsirr 407. tttgaagctacaaaggtaccgcataatggcagcacattaattaacaatgcgctaaacttt aatgaggcgctgatttgcttgtctttaaaagtcaacatagcactgataattcctaaaata gctactatacgtggaattgtcatgctcggatactgcggtatatgtaagaaagcaccaaga cctgctatcacaccacatactaacgcaatatatagaaattgcttcaaatcattcactcct aaattgttattacactattacaca 408. featkvphngstlinnalnfnealiclslkvnialiipkiatirgivmlgycgickkapr paitphtnaiyrncfksftpklllhyyt 409. atgcttgctgctcgcatactattagaatctggtgcagaaggtacgcgtgtagaagatacc atgacacgtattgcaaaaaaacttggttacagtgaaagtaacagctttgttacaaacact gtcatccagtttacgttacattcggaatcgtttcctagaatatttagaattacctctcga gatacaaacttaataaaaatttctcaagctaataaaatttcgcgtcaaattacaaacaat gaaatttctttagccgaagcaaaaacgcaacttgaaaaaatatatgttgctaagcgtgac agcagtcttccctttaaaggttttgctgcagcaatgattgcaatgagtttcttatattta caaggtggtagattgattgatgtttta actgcgatattagcaggtagtctaggataccta gtcactgagattttagatcgtaagttacacgcacagtttatcccagaattcattggttca ttagttattgggattatcgccgttattggacatacacttattccaacaggtgacttggca actattatcattgcggcagtcatgcctattgttcctggtgtattaataacaaacgcaata caagatttatttggtggacacatgttgatgttcacaacgaaatcattagaagcattggtt actgcgtttggcatcggtgctggcgttggtagcgtattaattttagta 410. mlaarillesgaegtrvedtmtriakklgysesnsfvtntviqftlhsesfprifritsr dtnlikisqankisrqitnneislaeaktqlekiyvakrdsslpfkgfaaamiamsflyl qggrlidvltailagslgylvteildrklhaqfipefigslvigiiavightliptgdla tiiiaavmpivpgvlitnaiqdlfgghmlmfttkslealvtafgigagvgsvlilv 411. atgacatttaataaagtattattgagctggatagtcatattgattataacaactagcata tatctattttggcagttgggcgatatcaatgatgtatttaaccagtctattttaatcaat gttagattaccgagattattagaagcattgttgacaggtatgatattaactgttgcaggc cttatatttcaaacagttttaaataatgcattggcagatagctttacattaggattggca agcggcgctacatttggttcaggattagcattatttttaggtttaacaacgttatggatt cctgtattttcaataacatttagtttgataacattaataactgtattagtcattacgtcg gtattgagccaaggctatccagttagaatcttaatattaagtggtttaatgattggt gcg ttattcaattcacttctatattttttgattttattaaaacctcgcaaattaaatacaatt gccaattatctgtttggtggttttggtgatgcagaatactcaaatgtatctataatagca atcacatttatcattgcattgtttggtatatttatcattcttaatcaactaaagttattg caattaggagaactaaaaagtcagtcactaggcttaaatgttcaattgattacatatatc gcgttatgtatagcttctatgataacggcgataaatgtcgcatatgttggcatcattgga ttcattggtatggtgataccgcaactcattagaaaatggcagtggaaacaatcattagga agacaattggctttaaatattgtaactggaggacaaataatggttatggcagattttatt ggtagccatatattgtcaccagtacaaataccggcaagtattatcattgcattaattggt ataccagtgttattttacatgctaatatctcagtcgaaacggttacac 412. mtfnkvllswiviliittsiylfwqlgdindvfnqsilinvrlprllealltgmiltvag lifqtvlnnaladsftlglasgatfgsglalflglttlwipvfsitfslitlitvlvits vlsqgypvrililsglmigalfnsllyflillkprklntianylfggfgdaeysnvsiia itfiialfgifiilnqlkllqlgelksqslglnvqlityialciasmitainvayvgiig figmvipqlirkwqwkqslgrqlalnivtggqimvmadfigshilspvqipasiiialig ipvlfymlisqskrlh 413. atgaacaaacagcaaaaagaatttaaatcattttattcaattagaaagtcatcactaggc gttgcatctgtagcaattagtacacttttattattaatgtcaaatggcgaagcacaagca gcagc tgaagaaacaggtggtacaaatacagaagcacaaccaaaaactgaagcagttgca agtccaacaacaacatctgaaaaagctccagaaactaaaccagtagctaatgctgtctca gtatctaataaagaagttgaggcccctacttctgaaacaaaagaagctaaagaagttaaa gaagttaaagcccctaaggaaacaaaagaagttaaaccagcagcaaaagccactaacaat acatatcctattttgaatcaggaacttagagaagcgattaaaaaccctgcaataaaagac aaagatcatagcgcaccaaactctcgtccaattgattttgaaatgaaaaagaaagatgga actcaacagttttatcattatgcaagttctgttaaacctgctagagttattttcactgat tcaaaaccagaaattgaattaggattacaatcaggtcaattttggagaaaatttgaagtt tatgaaggtgacaaaaagttgccaattaaattagtatcatacgatactgttaaagattat gcttacattcgcttctctgtatcaaacggaacaaaagctgttaaaattgttagttcaaca cacttcaataacaaagaagaaaaatacgattacacattaatggaattcgcacaaccaatt tataacagtgcagataaattcaaaactgaagaagattataaagctgaaaaattattagcg ccatataaaaaagcgaaaacactagaaagacaagtttatgaattaaataaaattcaagat aaacttcctgaaaaattaaaggctgagtacaagaagaaattagaggatacaaagaaagct ttagatgagcaagtgaaatcagctattactgaattccaaaatgtacaaccaacaaatgaa aaaatgactgatttacaagatacaaaatatgttgtttatgaaagtgttgagaataacgaa tctatgatggatacttttgttaaacaccc tattaaaacaggtatgcttaacggcaaaaaa tatatggtcatggaaactactaatgacgattactggaaagatttcatggttgaaggtcaa cgtgttagaactataagcaaagatgctaaaaataatactagaacaattattttcccatat gttgaaggtaaaactctatatgatgctatcgttaaagttcacgtaaaaacgattgattat gatggacaataccatgtcagaatcgttgataaagaagcatttacaaaagccaataccgat aaatctaacaaaaaagaacaacaagataactcagctaagaaggaagctactccagctacg cctagcaaaccaacaccatcacctgttgaaaaagaatcacaaaaacaagacagccaaaaa gatgacaataaacaattaccaagtgttgaaaaagaaaatgacgcatctagtgagtcaggt aaagacaaaacgcctgctacaaaaccaactaaaggtgaagtagaatcaagtagtacaact ccaactaaggtagtatctacgactcaaaatgttgcaaaaccaacaactgcttcatcaaaa acaacaaaagatgttgttcaaacttcagcaggttctagcgaagcaaaagatagtgctcca ttacaaaaagcaaacattaaaaacacaaatgatggacacactcaaagccaaaacaataaa aatacacaagaaaataaagcaaaatcattaccacaaactggtgaagaatcaaataaagat atgacattaccattaatggcattattagctttaagtagcatcgttgcattcgtattacct agaaaacgtaaaaac 414. MNKQQKEFKSFYSIRKSSLGVASVAISTLLLLMSNGEAQAAAEETGGTNTEAQPKTEAVA SPTTTSEKAPETKPVANAVSVSNKEVEAPTSETKEAKEVKEVKAPKETKEVKPAAKATNN TYPILNQELREAIKNPAIKDKDHSAPNSRPID FEMKKKDGTQQFYHYASSVKPARVIFTD SKPEIELGLQSGQFWRKFEVYEGDKKLPIKLVSYDTVKDYAYIRFSVSNGTKAVKIVSST HFNNKEEKYDYTLMEFAQPIYNSADKFKTEEDYKAEKLLAPYKKAKTLERQVYELNKIQD KLPEKLKAEYKKKLEDTKKALDEQVKSAITEFQNVQPTNEKMTDLQDTKYVVYESVENNE SMMDTFVKHPIKTGMLNGKKYMVMETTNDDYWKDFMVEGQRVRTISKDAKNNTRTIIFPY VEGKTLYDAIVKVHVKTIDYDGQYHVRIVDKEAFTKANTDKSNKKEQQDNSAKKEATPAT PSKPTPSPVEKESQKQDSQKDDNKQLPSVEKENDASSESGKDKTPATKPTKGEVESSSTT PTKVVSTTQNVAKPTTASSKTTKDVVQTSAGSSEAKDSAPLQKANIKNTNDGHTQSQNNK NTQENKAKSLPQTGEESNKDMTLPLMALLALSSIVAFVLPRKRKN 415. atgaattatccaaatggtaaaccatatcgtaaaaatagtgctatagacggagggaaaaag accgctgcctttagtaatattgagtatggtggacgtggtatgtcacttgaaaaagatatc gaacattcaaatacgttttatcttaaaagcgacattgcagttattcacaaaaagcctacg ccagtacaaatagttaatgtcaactatcctaagcggagtaaagctgtgattaacgaagct tattttcgtacaccttcaacaactgattacaacggcgtttatcaaggttattatattgat tttgaagcaaaggaaactaaaaacaagacgtcctttcctttaaataatattcatgaccat caagtcgaacatatgaaaaatgcatatcaacaaaaaggtattgtgtttttaatgattcgt tttaaaacgctagatgaagtttatcttttaccctattcaaaattcgaagtattttggaag agata taaagataatattaaaragtctataacagttgatgaaatacgaaaaaatggttac catattccttatcagtatcaaccaagattagactatctaaaagcagttgataagttgata ttagatgaaagtgaggaccgcgta 416. mnypngkpyrknsaidggkktaafsnieyggrgmslekdiehsntfylksdiavihkkpt pvqivnvnypkrskavineayfrtpsttdyngvyqgyyidfeaketknktsfplnnihdh qvehmknayqqkgivflmirfktldevyllpyskfevfwkrykdnikxsitvdeirkngy hipyqyqprldylkavdklildesedrv 417. ttgatatatctagataatgcggcaacgacgaaagcatttgaagaagtgttagatacttat ttaaaagtaaatcaatcaatgtattataatccgaatagtccgcataaagctggtttgcag gcaaatcaattactacaacaagcaaaaacccaaattaatgcaatgattaattcaaaaaca aattatgatgttgtattcactagtggtgcaactgaatccaataatcttgctttaaaaggt attgcctatcgtaaatttgatacagcgaaggaaataattacatccgtgttagagcatccg tccgtattagaggttgtaagatatttggaagcacacgaaggatttaaagttaaatatgtt gatgtaaagaaagatggcagtattaacttagaacacttcaaagaattaatgtcagacaaa gtcggtttagtaacatgtatgtatgtaaataatgtaactggacaaatacagcctattcca caaatggctaaagttataaaaaattatcctaaggcacattttcatgtagatgcggttcaa gcattcggcaaaatttcaatggatctcaataacatagatagtattagtttaagtggacac aagtttaatggtttaaaaggacaagg cgtcttacttgtaaatcacattcaaaatgttgaa ccaactgtccatggtggtggtcaagaatatggcgttagaagtggaacagttaatttgcca aatgatattgcaatggttaaagcgatgaagatagctaatgaaaactttgaagcattgaat gcatttgttactgagttaaataatgacgtccgtcaatttttaaataaatatcatggagtt tatattaattcttcaacttcaggttcaccattcgttttaaatattagttttcctggcgta aaaggtgaagtattagttaatgctttttcaaaatatgacattatgatatctacgacaagt gcttgttcatctaaacgtaataaattaaatgaagtattggctgcaatgggattatcagac aaatctattgaaggtagtataagattatcatttggggctactacaactaaagaagatata gcgaggtttaaagaaatatttatcatcatttatgaggaaattaaggagttgctaaaa 418. liyldnaattkafeevldtylkvnqsmyynpnsphkaglqanqllqqaktqinaminskt nydvvftsgatesnnlalkgiayrkfdtakeiitsvlehpsvlevvryleahegfkvkyv dvkkdgsinlehfkelmsdkvglvtcmyvnnvtgqiqpipqmakviknypkahfhvdavq afgkismdlnnidsislsghkfnglkgqgvllvnhiqnveptvhgggqeygvrsgtvnlp ndiamvkamkianenfealnafvtelnndvrqflnkyhgvyinsstsgspfvlnisfpgv kgevlvnafskydimisttsacsskrnklnevlaamglsdksiegsirlsfgatttkedi arfkeifiiiyeeikellk 419. atgtcatatcattggtttaagaaaatgttactttcaacaagtattttaattttaagtagt agtagtttagggcttgcaacgca cacagttgaagcaaaggataacttaaatggagaaaaa ccaactactaatttgaatcataatataacttcaccatcagtaaatagtgaaatgaataat aatgagactgggacacctcacgaatcaaatcaaacgggtaatgaaggaacaggttcgaat agtcgtgatgctaatcctgattcgaataatgtgaagccagactcaaacaaccaaaaccca agtacagattcaaaaccagacccaaataaccaaaacccaagtccgaatcctaaaccagat ccagataacccgaaaccaaaaccggatccaaaaccagacccagataaaccaaagccaaat ccggatccaaaaccagatccagataacccgaaaccaaatccagatccaaaaccagaccca gataaaccaaagccaaatccggatccaaaaccagatccagataaaccaaagccaaatccg aatccaaaaccagaccctaataagccaaatcctaacccgtcaccagatcccgatcaacct ggggattccaatcattctggtggctcgaaaaatggggggacatggaacccaaatgcttca gatggatctaatcaaggtcaatggcaaccaaatgggaatcaaggaaactcacaaaatcct actggtaatgattttgtatcccaacgatttttagccttggcaaatggggcttacaagtat aatccgtatattttaaatcaaattaataagttgggcaaagattatggagaagttactgat gaagacatttataatattattcgaaaacaaaatttcagcggaaatgcatatttaaatgga ttacaacagcaatcgaattactttagattccaatatttcaatccattgaaatcagaaagg tactatcgtaatttagatgaacaagtactcgcattaattactggtgaaattggatcaatg ccagatttgaaaaagcccgaagataagccggattcaaaacaacgctc atttgaaccgcat gaaaaagacgattttacagtagttaaaaaacaagaagataataagaaaagtgcgtcaact gcatatagtaaaagttggctagcaattgtatgttctatgatggtggtattttcaatcatg ctattcttatttgtaaagcgaaataaaaagaaaaataaaaacgaatcacagcgacga 420. msyhwfkkmllstsililsssslglathtveakdnlngekpttnlnhnitspsvnsemnn netgtphesnqtgnegtgsnsrdanpdsnnvkpdsnnqnpstdskpdpnnqnpspnpkpd pdnpkpkpdpkpdpdkpkpnpdpkpdpdnpkpnpdpkpdpdkpkpnpdpkpdpdkpkpnp npkpdpnkpnpnpspdpdqpgdsnhsggsknggtwnpnasdgsnqgqwqpngnqgnsqnp tgndfvsqrflalangaykynpyilnqinklgkdygevtdediyniirkqnfsgnaylng lqqqsnyfrfqyfnplkseryyrnldeqvlalitgeigsmpdlkkpedkpdskqrsfeph ekddftvvkkqednkksastayskswlaivcsmmvvfsimlflfvkrnkkknknesqrr 421. atgagagataagaaaggaccggtaaataaaagagtagattttctatcaaataaattgaat aaatattcaataagaaaatttacagttggaacagcatctattttaattggctcactaatg tatttgggaactcaacaagaggcagaagcagctgaaaacaatattgagaatccaactaca ttaaaagataatgtccaatcaaaagaagtgaagattgaagaagtaacaaacaaagacact gcaccacagggtgtagaagctaaatctgaagtaacttcaaacaaagacacaatcgaacat gaaccatcagtaaaagctgaagatatatcaaaaaaggaggatacaccaaaagaagtagct gatg ttgctgaagttcagccgaaatcgtcagtcactcataacgcagagacacctaaggtt agaaaagctcgttctgttgatgaaggctcttttgatattacaagagattctaaaaatgta gttgaatctaccccaattacaattcaaggtaaagaacattttgaaggttacggaagtgtt gatatacaaaaaaaaccaacagatttaggggtatcagaggtaaccaggtttaatgttggt aatgaaagtaatggtttgataggagctttacaattaaaaaataaaatagattttagtaag gatttcaattttaaagttagagtggcaaataaccatcaatcaaataccacaggtgctgat ggttgggggttcttatttagtaaaggaaatgcagaagaatatttaactaatggtggaatc cttggggataaaggtctggtaaattcaggcggatttaaaattgatactggatacatttat acaagttccatggacaaaactgaaaagcaagctggacaaggttatagaggatacggagct tttgtgaaaaatgacagttctggtaattcacaaatggttggagaaaatattgataaatca aaaactaattttttaaactatgcggacaattcaactaatacatcagatggaaagtttcat gggcaacgtttaaatgatgtcatcttaacttatgttgcttcaactggtaaaatgagagca gaatatgctggtaaaacttgggagacttcaataacagatttaggtttatctaaaaatcag gcatataatttcttaattacatctagtcaaagatggggccttaatcaagggataaatgca aatggctggatgagaactgacttgaaaggttcagagtttacttttacaccagaagcgcca aaaacaataacagaattagaaaaaaaagttgaagagattccattcaagaaagaacgtaaa tttaatccggatttagcaccagggacag aaaaagtaacaagagaaggacaaaaaggtgag aagacaataacgacaccaacactaaaaaatccattaactggagtaattattagtaaaggt gaaccaaaagaagagattacaaaagatccgattaatgaattaacagaatacggacctgaa acaatagcgccaggtcatcgagacgaatttgatccgaagttaccaacaggagagaaagag gaagttccaggtaaaccaggaattaagaatccagaaacaggagacgtagttagaccaccg gtcgatagcgtaacaaaatatggacctgtaaaaggagactcgattgtagaaaaagaagag attccattcgagaaagaacgtaaatttaatccggatttagcaccagggacagaaaaagta acaagagaaggacaaaaaggtgagaagacaataacgacaccaacactaaaaaatccatta actggagtaattattagtaaaggtgaaccaaaagaagaaatcacaaaagatccgattaat gaattaacagaatacggaccagaaacgataacaccaggtcatcgagacgaatttgatccg aagttaccaacaggagagaaagaggaagttccaggtaaaccaggaattaagaatccagaa acaggagacgtagttagaccaccggtcgatagcgtaacaaaatatggacctgtaaaagga gactcgattgtagaaaaagaagaaattccattcaagaaagaacgtaaatttaatccggat ttagcaccagggacagaaaaagtaacaagagaaggacaaaaaggtgagaagacaataacg acgccaacactaaaaaatccattaactggagaaattattagtaaaggtgaatcgaaagaa gaaatcacaaaagatccgattaatgaattaacagaatacggaccagaaacgataacacca ggtcatcgagacgaatttgatccgaagttaccaacaggagagaaagaggaag ttccaggt aaaccaggaattaagaatccagaaacaggagacgtagttagaccaccggtcgatagcgta acaaaatatggacctgtaaaaggagactcgattgtagaaaaagaagaaattccattcaag aaagaacgtaaatttaatcctgatttagcaccagggacagaaaaagtaacaagagaagga caaaaaggtgagaagacaataacgacgccaacactaaaaaatccattaactggagaaatt attagtaaaggtgaatcgaaagaagaaatcacaaaagatccgattaatgaattaacagaa tacggaccagaaacgataacaccaggtcatcgagacgaatttgatccgaagttaccaaca ggagagaaagaggaagttccaggtaaaccaggaattaagaatccagaaacaggagatgta gttagaccaccggtcgatagcgtaacaaaatatggacctgtaaaaggagactcgattgta gaaaaagaagaaattccattcgagaaagaacgtaaatttaatcctgatttagcaccaggg acagaaaaagtaacaagagaaggacaaaaaggtgagaagacaataacgacgccaacacta aaaaatccattaactggagaaattattagtaaaggtgaatcgaaagaagaaatcacaaaa gatccagttaatgaattaacagaattcggtggcgagaaaataccgcaaggtcataaagat atctttgatccaaacttaccaacagatcaaacggaaaaagtaccaggtaaaccaggaatc aagaatccagacacaggaaaagtgatcgaagagccagtggatgatgtgattaaacacgga ccaaaaacgggtacaccagaaacaaaaacagtagagataccgtttgaaacaaaacgtgag tttaatccaaaattacaacctggtgaagagcgagtgaaacaagaaggacaaccaggaagt aagacaatcacaaca ccaatcacagtgaacccattaacaggtgaaaaagttggcgagggt caaccaacagaagagatcacaaaacaaccagtagataagattgtagagttcggtggagag aaaccaaaagatccaaaaggacctgaaaacccagagaagccgagcagaccaactcatcca agtggcccagtaaatcctaacaatccaggattatcgaaagacagagcaaaaccaaatggc ccagttcattcaatggataaaaatgataaagttaaaaaatctaaaattgctaaagaatca gtagctaatcaagagaaaaaacgagcagaattaccaaaaacaggtttagaaagcacgcaa aaaggtttgatctttagtagtataattggaattgctggattaatgttattggctcgtaga agaaagaat 422. mrdkkgpvnkrvdflsnklnkysirkftvgtasiligslmylgtqqeaeaaennienptt lkdnvqskevkieevtnkdtapqgveaksevtsnkdtiehepsvkaediskkedtpkeva dvaevqpkssvthnaetpkvrkarsvdegsfditrdsknvvestpitiqgkehfegygsv diqkkptdlgvsevtrfnvgnesngligalqlknkidfskdfnfkvrvannhqsnttgad gwgflfskgnaeeyltnggilgdkglvnsggfkidtgyiytssmdktekqagqgyrgyga fvkndssgnsqmvgenidksktnflnyadnstntsdgkfhgqrlndviltyvastgkmra eyagktwetsitdlglsknqaynflitssqrwglnqginangwmrtdlkgseftftpeap ktitelekkveeipfkkerkfnpdlapgtekvtregqkgektittptlknpltgviiskg epkeeitkdpinelteygpetiapghrdefdpklptgekeevpgkpgiknpetgdvvrpp vdsvtkygpvkgdsivekeeipfe kerkfnpdlapgtekvtregqkgektittptlknpl tgviiskgepkeeitkdpinelteygpetitpghrdefdpklptgekeevpgkpgiknpe tgdvvrppvdsvtkygpvkgdsivekeeipfkkerkfnpdlapgtekvtregqkgektit tptlknpltgeiiskgeskeeitkdpinelteygpetitpghrdefdpklptgekeevpg kpgiknpetgdvvrppvdsvtkygpvkgdsivekeeipfkkerkfnpdlapgtekvtreg qkgektittptlknpltgeiiskgeskeeitkdpinelteygpetitpghrdefdpklpt gekeevpgkpgiknpetgdvvrppvdsvtkygpvkgdsivekeeipfekerkfnpdlapg tekvtregqkgektittptlknpltgeiiskgeskeeitkdpvneltefggekipqghkd ifdpnlptdqtekvpgkpgiknpdtgkvieepvddvikhgpktgtpetktveipfetkre fnpklqpgeervkqegqpgsktittpitvnpltgekvgegqpteeitkqpvdkivefgge kpkdpkgpenpekpsrpthpsgpvnpnnpglskdrakpngpvhsmdkndkvkkskiakes vanqekkraelpktglestqkglifssiigiaglmllarrrkn 423. gtgaaaagcaatcttagatacggcataagaaaacacaaattgggagcggcctcagtattc ttaggaacaatgatcgttgttggaatgggacaagaaaaagaagctgcagcatcggaacaa aacaatactacagtagaggaaagtgggagttcagctactgaaagtaaagcaagcgaaaca caaacaactacaaataacgttaatacaatagatgaaacacaatcatacagcgcgacatca actgagcaaccatcacaatcaacacaagtaacaacagaagaagcaccgaaaactgtgcaa gcaccaaaagtagaaacttcgcgagttgatttgccatcggaaaaagttgctgataaggaa actacaggaactcaagttgacatagctcaaccaagtaacgtctcagaaattaaaccaaga atgaaaagatcaactgacgttacagcagttgcagagaaagaagtagtggaagaaactaaa gcgacaggtacagatgtaacaaataaagtggaagtagaagaaggtagtgaaattgtagga cataaacaagatacgaatgttgtaaatcctcataacgcagaaagagtaaccttgaaatat aaatggaaatttggagaaggaattaaggcgggagattattttgatttcacattaagcgat aatgttgaaactcatggtatctcaacactgcgtaaagttccggagataaaaagtacagat ggtcaagttatggcgacaggagaaataattggagaaagaaaagttagatatacgtttaaa gaatatgtacaagaaaagaaagatttaactgctgaattatctttaaatctatttattgat cctacaacagtgacgcaaaaaggtaaccaaaatgttgaagttaaattgggtgagactacg gttagcaaaatatttaatattcaatatttaggtggagttagagataattggggagtaaca gctaatggtcgaattgatactttaaataaagtagatgggaaatttagtcattttgcgtac atgaaacctaacaaccagtcgttaagctctgtgacagtaactggtcaagtaactaaagga aataaaccaggggttaataatccaacagttaaggtatataaacacattggttcagacgat ttagctgaaagcgtatatgcaaagcttgatgatgtcagcaaatttgaagatgtgactgat aatatgagtttagattttgatactaatggtggttattctttaaactttaataatttagac caaagtaaaaattatgtaataaa atatgaagggtattatgattcaaatgctagcaactta gaatttcaaacacacctttttggatattataactattattatacaagtaatttaacttgg aaaaatggcgttgcattttactctaataacgctcaaggcgacggcaaagataaactaaag gaacctattatagaacatagtactcctatcgaacttgaatttaaatcagagccgccagtg gagaagcatgaattgactggtacaatcgaagaaagtaatgattctaagccaattgatttt gaatatcatacagctgttgaaggtgcagaaggtcatgcagaaggtaccattgaaactgaa gaagattctattcatgtagactttgaagaatcgacacatgaaaattcaaaacatcatgct gatgttgttgaatatgaagaagatacaaacccaggtggtggtcaggttactactgagtct aacctagttgaatttgacgaagattctacaaaaggtattgtaactggtgctgttagcgat catacaacaattgaagatacgaaagaatatacgactgaaagtaatctgattgaactagta gatgaactacctgaagaacatggtcaagcgcaaggaccaatcgaggaaattactgaaaac aatcatcatatttctcattctggtttaggaactgaaaatggtcacggtaattatggcgtg attgaagaaatcgaagaaaatagccacgtggatattaagagtgaattaggttacgaaggt ggccaaaatagcggtaatcagtcatttgaggaagacacagaagaagataaaccgaaatat gaacaaggtggcaatatcgtagatatcgatttcgatagtgtacctcaaattcatggtcaa aataatggtaaccaatcattcgaagaagatacagagaaagacaaacctaagtatgaacaa ggtggtaatatcattgatatcgacttcgacagtgtgccacatattca cggattcaataag cacactgaaattattgaagaagatacaaataaagataaaccaaattatcaattcggtgga cacaatagtgttgactttgaagaagatacacttccacaagtaagtggtcataatgaaggt caacaaacgattgaagaagatacaacacctccaatcgtgccaccaacgccaccgacacca gaagtaccaagcgagccggaaacaccaacaccaccgacaccagaagtaccaagcgagccg gaaacaccaacaccgccaacgccagaggtaccaactgaacctggtaaaccaataccacct gctaaagaagaacctaaaaaaccttctaaaccagtggaacaaggtaaagtagtaacacct gttattgaaatcaatgaaaaggttaaagcagtggtaccaactaaaaaagcacaatctaag aaatctgaactacctgaaacaggtggagaagaatcaacaaacaacggcatgttgttcggc ggattatttagcattttaggtttagcgttattacgcagaaataaaaagaatcacaaagca 424. vksnlrygirkhklgaasvflgtmivvgmgqekeaaaseqnnttveesgssateskaset qtttnnvntidetqsysatsteqpsqstqvtteeapktvqapkvetsrvdlpsekvadke ttgtqvdiaqpsnvseikprmkrstdvtavaekevveetkatgtdvtnkveveegseivg hkqdtnvvnphnaervtlkykwkfgegikagdyfdftlsdnvethgistlrkvpeikstd gqvmatgeiigerkvrytfkeyvqekkdltaelslnlfidpttvtqkgnqnvevklgett vskifniqylggvrdnwgvtangridtlnkvdgkfshfaymkpnnqslssvtvtgqvtkg nkpgvnnptvkvykhigsddlaesvyaklddvskfedvtdnmsldfdtnggyslnfnnld qskny vikyegyydsnasnlefqthlfgyynyyytsnltwkngvafysnnaqgdgkdklk epiiehstpielefkseppvekheltgtieesndskpidfeyhtavegaeghaegtiete edsihvdfeesthenskhhadvveyeedtnpgggqvttesnlvefdedstkgivtgavsd httiedtkeyttesnlielvdelpeehgqaqgpieeitennhhishsglgtenghgnygv ieeieenshvdikselgyeggqnsgnqsfeedteedkpkyeqggnivdidfdsvpqihgq nngnqsfeedtekdkpkyeqggniididfdsvphihgfnkhteiieedtnkdkpnyqfgg hnsvdfeedtlpqvsghnegqqtieedttppivpptpptpevpsepetptpptpevpsep etptpptpevptepgkpippakeepkkpskpveqgkvvtpvieinekvkavvptkkaqsk kselpetggeestnngmlfgglfsilglallrrnkknhka 425. atgaaagctttattacttaaaacaagtgtatggctcgttttgctttttagtgtaatggga ttatggcaagtctcgaacgcggctgagcagcatacaccaatgaaagcacatgcagtaaca acgatagacaaagcaacaacagataagcaacaagtaccgccaacaaaggaagcggctcat cattctggcaaagaagcggcaaccaacgtatcagcatcagcgcagggaacagctgatgat acaaacagcaaagtaacatccaacgcaccatctaacaaaccatctacagtagtttcaaca aaagtaaacgaaacacgcgacgtagatacacaacaagcctcaacacaaaaaccaactcac acagcaacgttcaaattatcaaatgctaaaacagcatcactttcaccacgaatgtttgct gctaatgcaccacaaacaacaacacataaaatattacatacaaa tgatatccatggccga ctagccgaagaaaaagggcgtgtcatcggtatggctaaattaaaaacagtaaaagaacaa gaaaagcctgatttaatgttagacgcaggagacgccttccaaggtttaccactttcaaac cagtctaaaggtgaagaaatggctaaagcaatgaatgcagtaggttatgatgctatggca gtcggtaaccatgaatttgactttggatacgatcagttgaaaaagttagagggtatgtta gacttcccgatgctaagtactaacgtttataaagatggaaaacgcgcgtttaagccttca acgattgtaacaaaaaatggtattcgttatggaattattggtgtaacgacaccagaaaca aagacgaaaacaagacctgaaggcattaaaggcgttgaatttagagatccattacaaagt gtgacagcggaaatgatgcgtatttataaagacgtagatacatttgttgttatatcacat ttaggaattgatccttcaacacaagaaacatggcgtggtgattacttagtgaaacaatta agtcaaaatccacaattgaagaaacgtattacagttattgatggtcattcacatacagta cttcaaaatggtcaaatttataacaatgatgcattggcacaaacaggtacagcacttgcg aatatcggtaagattacatttaattatcgcaatggagaggtatcgaatattaaaccgtca ttgattaatgttaaagacgttgaaaatgtaacaccgaacaaagcattagctgaacaaatt aatcaagctgatcaaacatttagagcacaaactgcagaggtaattattccaaacaatacc attgatttcaaaggagaaagagatgacgttagaacgcgtgaaacaaatttaggaaacgcg attgcagatgctatggaagcgtatggcgttaagaatttctctaaaaagactgactttgcc gtgacaa atggtggaggtattcgtgcctctatcgcaaaaggtaaggtgacacgctatgat ttaatctcagtattaccatttggaaatacgattgcgcaaattgatgtaaaaggttcagac gtctggacggctttcgaacatagtttaggcgcaccaacaacacaaaaggacggtaagaca gtgttaacagcgaatggcggtttactacatatctctgattcaatccgtgtttactatgat ataaataaaccgtctggcaaacgaattaatgctattcaaattttaaataaagagacaggt aagtttgaaaatattgatttaaaacgtgtatatcacgtaacgatgaatgacttcacagca tcaggtggcgacggatatagtatgttcggtggtcctagagaagaaggtatttcattagat caagtactagcaagttatttaaaaacagctaacttagctaagtatgatacgacagaacca caacgtatgttattaggtaaaccagcagtaagtgaacaaccagctaaaggacaacaaggt agcaaaggtagtaagtctggtaaagatacacaaccaattggtgacgacaaagtgatggat ccagcgaaaaaaccagctccaggtaaagttgtattgttgctagcgcatagaggaactgtt agtagcggtacagaaggttctggtcgcacaatagaaggagctactgtatcaagcaagagt gggaaacaattggctagaatgtcagtgcctaaaggtagcgcgcatgagaaacagttacca aaaactggaactaatcaaagttcaagcccagaagcgatgtttgtattattagcaggtata ggtttaatcgcgactgtacgacgtagaaaagctagc 426. mkalllktsvwlvllfsvmglwqvsnaaeqhtpmkahavttidkattdkqqvpptkeaah hsgkeaatnvsasaqgtaddtnskvtsnapsnkpstvvstkvnetrdvdt qqastqkpth tatfklsnaktaslsprmfaanapqttthkilhtndihgrlaeekgrvigmaklktvkeq ekpdlmldagdafqglplsnqskgeemakamnavgydamavgnhefdfgydqlkklegml dfpmlstnvykdgkrafkpstivtkngirygiigvttpetktktrpegikgvefrdplqs vtaemmriykdvdtfvvishlgidpstqetwrgdylvkqlsqnpqlkkritvidghshtv lqngqiynndalaqtgtalanigkitfnyrngevsnikpslinvkdvenvtpnkalaeqi nqadqtfraqtaeviipnntidfkgerddvrtretnlgnaiadameaygvknfskktdfa vtngggirasiakgkvtrydlisvlpfgntiaqidvkgsdvwtafehslgapttqkdgkt vltanggllhisdsirvyydinkpsgkrinaiqilnketgkfenidlkrvyhvtmndfta sggdgysmfggpreegisldqvlasylktanlakydttepqrmllgkpavseqpakgqqg skgsksgkdtqpigddkvmdpakkpapgkvvlllahrgtvssgtegsgrtiegatvssks gkqlarmsvpkgsahekqlpktgtnqssspeamfvllagigliatvrrrkas 427. atgaataaaaattcgaagaagaagctcgattttcttccaaacaagcttaataagtactca attagacgtttcactgtagggacagcttcgattttagtaggagctactttaattttcggt gttgcaaatgatcaagcagaagccgctgagaataacacaactcaaaagcaagatgatagt tcagatgcaagtaaagtaaaaggtaatgttcaaactattgaacaatcttctgcaaattca aatgaatctgatattcctgaacaagttgatgtaactaaagatacaactgaacaagcatca acagaagaaaaagcaa atacaactgaacaagcatcaacagaagaaaaagcagatacaact gaacaagcaacaacagaagaagcgccaaaagctgaaggaacagacaaagtagaaacagaa gaagcgccaaaagctgaagaaacagacaaagcaacaacagaagaagcgccaaaagctgaa gaaacagacaaagcaacagaagaagcaccaaaaactgaagaaacagacaaagcaacaaca gaagaagcgccagcagctgaagaaacaagcaaagcagcaacagaagaagcgccaaaagct gaagaaacaagcaaagcagcaacagaagaagcgccaaaagctgaagaaacagaaaaaaca gcaacagaagaagcaccaaaaactgaagaaacagacaaagtagaaacagaagaagcgcca aaagctgaagaaacaagcaaagcagcaacagaaaaagcaccaaaagctgaagaaacaaac aaagtagaaacagaagaagcgccagcagctgaagaaacaaacaaagcagcaacagaagaa acaccagcagttgaagacacaaatgctaagagcaattcaaatgctcaaccatcagaaact gagagaactcaagttgtagatacagttgctaaagatttatataaaaaatctgaagttaca gaagcagaaaaagctgaaattgaaaaagtattaccaaaagatatttcaaacttatctaat gaagaaattaaaaaaatagctttaagtgaagtacttaaagaaacagctaacaaagaaaac gcacaaccaagagcaacattccgttcagtaagcagcaatgctagaacaacaaatgttaac tattcagcaacagcattaagagcagctgcacaagacacagttactaaaaaaggaactggt aactttactgcgcatggagatataatccataaaacttataaagaagaattccctaatgaa ggcacgctaactgcattcaatacaaacttcaatcctaata caggaactaaaggcgcatta gaatataatgataaaatagattttaataaagactttacaattactgttccagtagcaaac aacaaccaaggtaatacaacaggagcagatggctggggcttcatgtttactcaagggaat ggccaagacttcttaaaccaaggtggtattttaagagacaaaggtatggcaaatgcatct ggttttaaaattgatacggcatataataatgttaatggtaaagtcgataaactcgatgca gataaaacaaacaatctaagtcaaattggcgcagcaaaagttggttacggtacatttgtt aaaaatggtgcagatggtgtgactaaccaagttggtcaaaatgccctaaatacaaaagat aaacctgtaaataaaataatttatgcagataatacaactaatcatcttgatggtcaattc catggccaaagattaaatgatgtagtattaaattatgatgcagcaacaagtacaataact gctacatatgcaggaaaaacatggaaagctactacagatgatttaggaattgataaatca caaaaatataatttcttaattacttcaagtcatatgcaaaatagatattctaatggaatt atgagaacaaatcttgaaggtgtaacaattacaacgcctcaagctgatttaattgatgat gtggaagtaacgaaacaaccaattcctcataaaactattcgtgagtttgatccaactcta gaaccaggctcacctgatgttattgtacaaaaaggtgaagatggagagaaaacaacaact acaccaactaaagttgaccctgatacaggagatgtagttgaacgtggtgaaccaacaaca gaagttacaaaaaatccagttgacgagattgtacactttacacctgaagaagtaccacaa ggtcataaagatgagttcgatccaaacttaccaattgacggtacagaagaagtaccaggt aaa ccaggcatcaagaatcctgaaacaggtgaagtagtaacacctccggttgacgatgtc acaaaacatggtccaaaagcaggcgaaccagaggttactaaagaagaaataccattcgag aaaaaacgtgagttcaatccagacttaaaaccaggtgaagagaaagtaacgcaagaagga caaactggagagaaaacaacaacaacgccaacaacaattaatccattaacgggagaaaaa gtaggcgaaggtgaaccaacaacagaagtaacaaaagaaccagtagatgaaatcacacaa ttcggtggagaagaagtaccacaaggtcataaagatgagttcgatccaaacttaccaatt gacggtacagaagaagtaccaggtaaaccaggcatcaagaatcctgaaacaggtgaagta gtaacacctccggttgacgatgtcacaaaacatggtccaaaagcaggcgaaccagaggtt actaaagaagaaataccattcgagaaaaaacgtgagttcaatccagacttaaaaccaggt gaagagaaagtaacgcaagaaggacaaactggagagaaaacaacaacaacgccaacaaca attaatccattaacgggagaaaaagtaggcgaaggtgaaccaacaacagaagtaacaaaa gaaccagtagatgaaatcacacaattcggtggagaagaagtaccacaaggtcataaagat gagttcgatccaaacttaccaattgacggtacagaagaagtaccaggtaaaccaggcatc aagaatcctgaaacaggtgaagtagtaacacctccggttgacgatgtcacaaaacatggt ccaaaagcaggcgaaccagaggttactaaagaagaaataccattcgagaaaaaacgtgag ttcaatccagacttaaaaccaggtgaagagaaagtaacgcaagaaggacaaactggagag aaaacaacaacaacgccaacaacaatt aatccattaacgggagaaaaagtaggcgaaggt gaaccaacaacagaagtaacaaaagaaccagtagatgaaatcacacaattcggtggagaa gaagtaccacaaggtcataaagatgagttcgatccaaacttaccaattgacggtacagaa gaagtaccaggtaaaccaggcatcaagaatcctgaaacaggtgaagtagtaacaccacca gtagacgatgtcacaaaacatggtccaaaagcaggcgaaccagaggttactaaagaagaa attccatatgaaactaaacgcgtattagatccaacaatggaaccaggtagtcctgataaa gtagctcaaaaaggtgaaaatggtgaaaaaacaacaacaacaccaactacaattaatcca ttaacgggagaaaaagtaggcgaaggcgaaccaacaacggaagtaacgaaagaaccaata gacgaaattgttaactatgcacctgaaattattcctcatggtacacgtgaagaaattgat ccaaacttaccagaaggtgaaactaaagttatcccaggtaaagatggcttgaaagatcct gaaactggagaaatcattgaagaaccacaagatgaagtaatcatccatggtgctaaagat gattcagatgcggacagcgattcagacgcagatagcgattctgatgcagacagcgactca gacgcagatagcgactctgatgcggacagcgattcagacagcgatagcgattcagattca gatagcgactctgatgcggacagcgattcagacagcgatagcgattcagacgcagatagc gattctgatgcagacagcgactcagacgcagatagcgactcagattcagacgcagatagc gactcagattcagacgcagatagcgactcagattcagacagcgactcagacgcagacagc gactcagattcagacagcgattcagacgcagacagcgactcagacgcagat agcgactca gattcagacagcgattcagacgcagatagcgattcagattcagatagtgactctgatgcg gacagcgactcagacgcagatagcgactctgatgcggacagcgactcagacgcagatagc gattctgattcagacagcgattcagacgcagatagcgactcagacgcagatagcgattca gacgcagatagcgactcagacgcagatagcgattcagattcagatagcgactctgatgcg gacagcgatagcgattcagattcagacagcgactcagacgcagatagcgactcagacgca gatagcgatagcgattctgatgcagacagcgactcagacgcagatagcgactctgatgcg gacggcgactcagacgcagatagcgattctgatgcagacagcgactcagacagcgatagc gattctgattcagacagcgattcagacgcagatagcgactcagattcagacagcgattca gacgcagatagagatcataatgacaaaacagataaaccaaataataaagagttaccagat actggtaatgatgctcaaaataatggcacattatttggttcactattcgctgcgcttgga ggattattcttagttggcagacgtcgtaaaaacaaaaataatgaagaaaaa 428. mnknskkkldflpnklnkysirrftvgtasilvgatlifgvandqaeaaennttqkqdds sdaskvkgnvqtieqssansnesdipeqvdvtkdtteqasteekantteqasteekadtt eqatteeapkaegtdkveteeapkaeetdkatteeapkaeetdkateeapkteetdkatt eeapaaeetskaateeapkaeetskaateeapkaeetektateeapkteetdkveteeap kaeetskaatekapkaeetnkveteeapaaeetnkaateetpavedtnaksnsnaqpset ertqvvdtvakdlykkse vteaekaeiekvlpkdisnlsneeikkialsevlketanken aqpratfrsvssnarttnvnysatalraaaqdtvtkkgtgnftahgdiihktykeefpne gtltafntnfnpntgtkgaleyndkidfnkdftitvpvannnqgnttgadgwgfmftqgn gqdflnqggilrdkgmanasgfkidtaynnvngkvdkldadktnnlsqigaakvgygtfv kngadgvtnqvgqnalntkdkpvnkiiyadnttnhldgqfhgqrlndvvlnydaatstit atyagktwkattddlgidksqkynflitsshmqnrysngimrtnlegvtittpqadlidd vevtkqpiphktirefdptlepgspdvivqkgedgekttttptkvdpdtgdvvergeptt evtknpvdeivhftpeevpqghkdefdpnlpidgteevpgkpgiknpetgevvtppvddv tkhgpkagepevtkeeipfekkrefnpdlkpgeekvtqegqtgekttttpttinpltgek vgegepttevtkepvdeitqfggeevpqghkdefdpnlpidgteevpgkpgiknpetgev vtppvddvtkhgpkagepevtkeeipfekkrefnpdlkpgeekvtqegqtgekttttptt inpltgekvgegepttevtkepvdeitqfggeevpqghkdefdpnlpidgteevpgkpgi knpetgevvtppvddvtkhgpkagepevtkeeipfekkrefnpdlkpgeekvtqegqtge kttttpttinpltgekvgegepttevtkepvdeitqfggeevpqghkdefdpnlpidgte evpgkpgiknpetgevvtppvddvtkhgpkagepevtkeeipyetkrvldptmepgspdk vaqkgengekttttpttinpltgekvgegepttevtkepideivnyapeiiphgtreeid pnlpegetkvipgkdglkdpetgeiieepqdeviihgakdds dadsdsdadsdsdadsds dadsdsdadsdsdsdsdsdsdsdsdadsdsdsdsdsdadsdsdadsdsdadsdsdsdads dsdsdadsdsdsdsdsdadsdsdsdsdsdadsdsdadsdsdsdsdsdadsdsdsdsdsda dsdsdadsdsdadsdsdadsdsdsdsdsdadsdsdadsdsdadsdsdadsdsdsdsdsda dsdsdsdsdsdsdadsdsdadsdsdsdadsdsdadsdsdadgdsdadsdsdadsdsdsds dsdsdsdsdadsdsdsdsdsdadrdhndktdkpnnkelpdtgndaqnngtlfgslfaalg glflvgrrrknknneek 429. ttgaaaaagaaaaacatttattcaattcgtaaactaggtgtaggtattgcatctgtaact ttaggtacattacttatatctggtggcgtaacacctgctgcaaatgctgcgcaacacgat gaagctcaacaaaatgctttttatcaagtcttaaatatgcctaacttaaatgctgatcaa cgcaatggttttatccaaagccttaaagatgatccaagccaaagtgctaacgttttaggt gaagctcaaaaacttaatgactctcaagctccaaaagctgatgcgcaacaaaataacttc aacaaagatcaacaaagcgccttctatgaaatcttgaacatgcctaacttaaacgaagcg caacgtaacggcttcattcaaagtcttaaagacgacccaagccaaagcactaacgtttta ggtgaagctaaaaaattaaacgaatctcaagcaccgaaagctgataacaatttcaacaaa gaacaacaaaatgctttctatgaaatcttgaatatgcctaacttaaacgaagaacaacgc aatggtttcatccaaagcttaaaagatgacccaagccaaagtgctaacctattgtcagaa gctaaaaagttaaatgaatctcaagcaccgaaagcggataaca aattcaacaaagaacaa caaaatgctttctatgaaatcttacatttacctaacttaaacgaagaacaacgcaatggt ttcatccaaagcctaaaagatgacccaagccaaagcgctaaccttttagcagaagctaaa aagctaaatgatgctcaagcaccaaaagctgacaacaaattcaacaaagaacaacaaaat gctttctatgaaattttacatttacctaacttaactgaagaacaacgtaacggcttcatc caaagccttaaagacgatccttcagtgagcaaagaaattttagcagaagctaaaaagcta aacgatgctcaagcaccaaaagaggaagacaataacaagcctggcaaagaagacaataac aagcctggcaaagaagacaacaacaagcctggtaaagaagacaacaacaagcctggcaaa gaagacggcaacaagcctggtaaagaagacaacaaaaaacctggtaaagaagatggcaac aagcctggtaaagaagacaacaaaaaacctggtaaagaagacggcaacaagcctggcaaa gaagatggcaacaaacctggtaaagaagatggtaacggagtacatgtcgttaaacctggt gatacagtaaatgacattgcaaaagcaaacggcactactgctgacaaaattgctgcagat aacaaattagctgataaaaacatgatcaaacctggtcaagaacttgttgttgataagaag caaccagcaaaccatgcagatgctaacaaagctcaagcattaccagaaactggtgaagaa aatccattcatcggtacaactgtatttggtggattatcattagccttaggtgcagcgtta ttagctggacgtcgtcgcgaacta 430. lkkkniysirklgvgiasvtlgtllisggvtpaanaaqhdeaqqnafyqvlnmpnlnadq rngfiqslkddpsqsanvlgeaqklndsqapkadaqq nnfnkdqqsafyeilnmpnlnea qrngfiqslkddpsqstnvlgeakklnesqapkadnnfnkeqqnafyeilnmpnlneeqr ngfiqslkddpsqsanllseakklnesqapkadnkfnkeqqnafyeilhlpnlneeqrng fiqslkddpsqsanllaeakklndaqapkadnkfnkeqqnafyeilhlpnlteeqrngfi qslkddpsvskeilaeakklndaqapkeednnkpgkednnkpgkednnkpgkednnkpgk edgnkpgkednkkpgkedgnkpgkednkkpgkedgnkpgkedgnkpgkedgngvhvvkpg dtvndiakangttadkiaadnkladknmikpgqelvvdkkqpanhadankaqalpetgee npfigttvfgglslalgaallagrrrel 431. atgaagaaaacaattttactgacgatgacaactcttactttatttagtatgtcgcctaac tcggctcaagcatatacgaatgatagcaaaacattagaagaagcaaagaaagcacaccca aacgcacagttcaaagtgaataaagacaccggcgcgtatacttatacatatgacaaaaac aacacgccaaacaacaatcatcaaaaccagtcacgtacaaacgacaatcatcaacacgca aatcaacgtgatcttaacaacaatcagtaccattcttcattaagtggtcagtatacgcac attaatgacgcaattgattcacacacaccgcctcaaacgtcaccaagcaatcctttgaca ccagcaataccgaatgtcgaagacaatgacgatgaattaaataacgctttttcaaaagat aacaaagggcttattacaggcatcgatttagacgaattgtatgacgaattacaaatcgcc gaatttaatgacaaagcaaagaccgctgacggtaaacctttagcattaggtaacggtaaa atcattgatcagcctcttatcacaagt aagaacaacttatatactgctggacaatgtaca tggtatgtctttgataaacgtgccaaagatggacacacgattagtacattttggggagat gctaaaaactgggcaggccaagcttcaagcaatggcttcaaagtagatagacacccaaca cgaggatcaattttacaaacagtaaatggtccatttggtcatgtagcctacgttgaaaaa gttaatattgatggaagtattctaatttcagaaatgaactggattggtgaatatatcgtt tcatcaagaaccatctctgcttcagaagtttcatcatataattacatccat 432. mkktilltmttltlfsmspnsaqaytndsktleeakkahpnaqfkvnkdtgaytytydkn ntpnnnhqnqsrtndnhqhanqrdlnnnqyhsslsgqythindaidshtppqtspsnplt paipnvednddelnnafskdnkglitgidldelydelqiaefndkaktadgkplalgngk iidqplitsknnlytagqctwyvfdkrakdghtistfwgdaknwagqassngfkvdrhpt rgsilqtvngpfghvayvekvnidgsilisemnwigeyivssrtisasevssynyih 433. atgaatcaatatcattctaatgcacaacaaccaagtgcatggcgtttttttgtctatagt ttagtgggcatactatgtttctttattccttttacgattaatggtaacaacactattttc gtcgatcatgttcatctagccattcgctcaatcataggtccacttatgccctatgttgca ctgattatgattttaattggtacagcgttaccaatagtgagacgtacttttatgacttca atcacaaacttggtcattacattatttaaagttgcaggtgcaatgatcggtataatgtat gtatttaaaatcggtccatcaatactatttaaagctaactatggtccgttttt gtttgaa aaattaatgatgccattaagtatcttaattccagtaggtgcaattgcgctttctttatta gtgggctatggcttattagaatttgtcggtgtttatatggagcctattatgagacctatt tttaaaacaccaggaaaatccgctgtcgatgcagtggcttcgtttgtcggcagttattcc ttaggattattgattactaatcgtgtctataagcaagggatgtacaacaaacgagaagcc acgattattgcgactggcttttcaacagtttcagcaacttttatgattatcgttgctaaa actttaggattaatgccgcattggaatttatacttttggataactttagtcatcacattt gtcgtgactgcaattactgcatggctaccgccaatcagcaatgaatcaacagaatattat aacggacaagaaggagaacaagaagttgctattgaaggaagcagactgaaaactgcatat gcagaggcgatgaaacaaaatgcattaacaccatctctcgtgaagaacgtttgggacaat ttgaaagacggtttagaaatgactgttggtattttaccttctatattatcgattggtttt ttaggactgattgtagcgaactatacaccattcattgattggcttggctatatcttctat ccatttatttatattttcccaattgctgatcaggctttactagcaaaagcgtcagcgatt tctattgtagagatgtttctaccatctttgttagtaactaaagctgcaatgagtactaaa tttgtcgtcggtgtagtaagcgtatcagccattatctttttctcagcattagtgccatgt atactagcaactgaaattaaaatacctgtctggaaactcatcatcatttggtttttacgc gtggcgttgtcgctattaatcaccatccccgtcgctttacttatttttgga 434. mnqyhsnaqqpsawrffvys lvgilcffipftingnntifvdhvhlairsiigplmpyva limiligtalpivrrtfmtsitnlvitlfkvagamigimyvfkigpsilfkanygpflfe klmmplsilipvgaialsllvgygllefvgvymepimrpifktpgksavdavasfvgsys lgllitnrvykqgmynkreatiiatgfstvsatfmiivaktlglmphwnlyfwitlvitf vvtaitawlppisnesteyyngqegeqevaiegsrlktayaeamkqnaltpslvknvwdn lkdglemtvgilpsilsigflglivanytpfidwlgyifypfiyifpiadqallakasai sivemflpsllvtkaamstkfvvgvvsvsaiiffsalvpcilateikipvwkliiiwflr valsllitipvallifg 435. atgaaaatgagaacaattgctaaaaccagtttagcactagggcttttaacaacaggcgca attacagtaacgacgcaatcggtcaaagcagaaaaaatacaatcaactaaagttgacaaa gtaccaacgcttaaagcagagcgattagcaatgataaacataacagcaggtgcaaattca gcgacaacacaagcagctaacacaagacaagaacgcacgcctaaactcgaaaaggcacca aatactaatgaggaaaaaacctcagcttccaaaatagaaaaaatatcacaacctaaacaa gaagagcagaaaacgcttaatatatcagcaacgccagcgcctaaacaagaacaatcacaa acgacaaccgaatccacaacgccgaaaactaaagtgacaacacctccatcaacaaacacg ccacaaccaatgcaatctactaaatcagacacaccacaatctccaaccataaaacaagca caaacagatatgactcctaaatatgaagatttaagagcgtattatacaaaaccgagtttt gaatttgaaaagcagtttgga tttatgctcaaaccatggacgacggttaggtttatgaat gttattccaaataggttcatctataaaatagctttagttggaaaagatgagaaaaaatat aaagatggaccttacgataatatcgatgtatttatcgttttagaagacaataaatatcaa ttgaaaaaatattctgtcggtggcatcacgaagactaatagtaaaaaagttaatcacaaa gtagaattaagcattactaaaaaagataatcaaggtatgatttcacgcgatgtttcagaa tacatgattactaaggaagagatttccttgaaagagcttgattttaaattgagaaaacaa cttattgaaaaacataatctttacggtaacatgggttcaggaacaatcgttattaaaatg aaaaacggtgggaaatatacgtttgaattacacaaaaaactgcaagagcatcgtatggca ggcactaatattgataacattgaagtgaatataaaa 436. mkmrtiaktslalgllttgaitvttqsvkaekiqstkvdkvptlkaerlaminitagans attqaantrqertpklekapntneektsaskiekisqpkqeeqktlnisatpapkqeqsq tttesttpktkvttppstntpqpmqstksdtpqsptikqaqtdmtpkyedlrayytkpsf efekqfgfmlkpwttvrfmnvipnrfiykialvgkdekkykdgpydnidvfivlednkyq lkkysvggitktnskkvnhkvelsitkkdnqgmisrdvseymitkeeislkeldfklrkq liekhnlygnmgsgtivikmknggkytfelhkklqehrmagtnidnievnik 437. atgaaaataacaacgattgctaaaacaagtttagcactaggccttttaacaacaggtgta atcacaacgacaacgcaagcagcaaacgcgacaacaccatcttccactaaagtggaagca ccacaa tcaacaccgccctcaactaaaatagaagcaccgcaatcaaaaccaaacgcgaca acaccgccctcaactaaagtagaagcaccgcaacaaacagcaaatgcgacaacaccgcct tcaactaaagtgacaacacctccatcaacaaacacgccacaaccaatgcaatctactaaa tcagacacaccacaatcgccaaccacaaaacaagtaccaacagaaataaatcctaaattt aaagatttaagagcgtattatacgaaaccaagtttagaatttaaaaatgagattggtatt attttaaaaaaatggacgacaataagatttatgaatgttgtcccagattatttcatatat aaaattgctttagttggtaaagatgataaaaaatatggtgaaggagtacataggaatgtc gatgtatttgtcgttttagaagaaaataattacaatctggaaaaatattctgtcggtggt atcacaaagagtaatagtaaaaaagttgatcacaaagcaggagtaagaattactaaggaa gataataaaggtacaatctctcatgatgtttcagaattcaagattactaaagaacagatt tccttgaaagaacttgattttaaattgagaaaacaacttattgaaaaaaataatctgtac ggtaacgttggttcaggtaaaattgttattaaaatgaaaaacggtggaaagtacacgttt gaattgcacaaaaaattacaagaaaatcgcatggcagatgtcattaatagtgaacaaatt aaaaacatcgaagtgaatttgaaa 438. mkittiaktslalgllttgvittttqaanattpsstkveapqstppstkieapqskpnat tppstkveapqqtanattppstkvttppstntpqpmqstksdtpqspttkqvpteinpkf kdlrayytkpslefkneigiilkkwttirfmnvvpdyfiykialvgkddkkygegvhrnv dvfvvleennynlekysvggitksnskkvdhkagvritkednkgtishdvsefkitkeqi slkeldfklrkqlieknnlygnvgsgkivikmknggkytfelhkklqenrmadvinseqi knievnlk 439. gtgaattatcgtgataaaattcaaaagtttagtattcgtaaatatacagttggtacattt tcaactgtcattgcgacattggtatttttaggattcaatacatcacaagcacatgctgct gaaacaaatcaaccagcaagcgtggttaaacagaaacaacaaagtaataatgaacagact gagaatcgagaatctcaagtacaaaattctcaaaattcacaaaatggtcaatcattatct gctactcatgaaaatgagcaaccaaatattagtcaagctaatttagtagatcaaaaagta gcgcaatcatctactactaatgatgaacaaccagcatctcaaaatgtaaatacaaagaaa gattcggcaacggctgcgacaacacaaccagataaagaacaaagtaagcataaacaaaac gaaagtcaatctgctaataaaaatggaaacgacaatagagcggctcatgtagaaaatcat gaagcaaatgtagtaacagcttcagattcatctgataatggtaacgtacaacatgaccga aatgaattacaagcgttttttgatgcaaattatcatgattatcgctttattgaccgtgaa aatgcagattctggcacatttaactatgtaaaaggcatttttgataagattaatacgtta ttaggcagtaatgatccaataaacaataaagacttgcaacttgcatacaaagaattggaa caagctgttgctttaattcgtacaatgcctcaacgtcaacagactagccgacgttcaaat agaattcaaacgcgttcggttgagtcaagagctgcagagcctagatcagtatcagactat caaaatgcaa attcatcatattatgttgaaaatgctaatgatggttcgggctatcctgtt ggtacatatatcaatgcttctagtaaaggggcgccatataatttaccaactacaccatgg aatacattgaaggcctctgactcaaaggaaattgctcttatgacagcgaaacaaactgga gacgggtaccaatgggttattaagtttaataaaggacatgctccacatcaaaatatgatc ttttggtttgcattaccagcagaccaagtgccagtaggaagaactgactttgtaacagtt aattcagatggaacaaatgtacaatggagtcatggagcaggagcaggtgcaaataaacca cttcaacaaatgtgggaatatggagtaaatgatcctcatcgttcacatgactttaaaata agaaatagaagtggccaagtaatatatgactggccaactgtccatatttattctttagaa gatttatctagagcgagtgattattttagtgaagctggagcgacacctgctactaaagct tttggtagacaaaattttgaatatattaatggtcaaaaacctgctgaatcaccgggtgtt cctaaagtttatactttcatcggtcaaggtgatgcaagttatacaatttcatttaaaaca caaggtccaactgttaataaattgtactatgcagcaggtgggcgtgctttagagtacaat caattatttatgtacagtcaactatacgtcgaatcaacgcaagaccatcaacaacgtctt aatggtttaagacaagtggttaatcgtacatatcgcataggtacaactaaacgtgtagaa gtgagtcaaggaaatgtacaaacgaaaaaggtattagaaagtacaaacctaaatatagat gattttgttgatgatcctttaagttatgttaagacgccgagtaataaagtgttaggattt tattcgaataatgcaaatactaatgcttttagac cgggtggagcccaacaattaaatgaa tatcaattaagtcaattatttactgatcaaaaattacaagaagcagcaagaactagaaac ccaataagattaatgattggtttcgactatcctgatgcttatggtaatagtgaaacttta gttcctgttaacttaacggtattacctgaaatccaacataatattaaattctttaaaaat gacgatactcaaaatattgctgaaaaaccattttcaaaacaagctgggcatccagttttc tatgtatatgcaggtaaccaagggaatgcttccgtgaatttaggtggtagcgtaacatct attcaaccattacgtattaatttaacaagtaatgagaattttacagataaagattggcaa attacaggtattccgcgtacattacacattgaaaactcgacaaatagacctaataatgcc agagaacgcaatattgaacttgttggtaacttattaccaggggattactttggaacgata cgttttggacgtaaagaacaattattcgaaattcgtgttaaaccacatacaccaacaatt acaacgacagctgagcaattaagaggtacagcattacaaaaagtgcctgttaatatttcg ggaataccgttggatccatcggcattggtttatttagttgcaccaacaaatcaaactacg aatggtggtagtgaggcagatcaaataccatctggttatacgatacttgcgactggtaca cctgatggggtgcataatacaattactatacgaccgcaagattatgttgtattcatacca cctgtaggtaaacaaattagagcagtagtttattataataaagtagttgcatctaatatg agtaatgctgttactattttgccagatgacattccaccaacaatcaataatcctgttgga ataaatgccaaatactatcgaggcgacgaagtcaactttacaatgggtgtctctgata ga cattctggtataaaaaatacaactattacgacattgccgaatggttggacatcaaattta acaaaagcggataagaataatggctcattatctattacaggtagagtgagtatgaatcag gcatttaacagtgatattacatttaaagtgtcagcgacagacaatgtcaataatacgaca aatgatagtcaatctaaacatgtttcaattcatgtaggtaaaattagtgaagatgctcat ccgattgtattaggaaatactgagaaagttgtagtagtcaatccgactgctgtatctaat gatgaaaagcaaagcataattactgcctttatgaataaaaaccaaaatataagaggatat ttagcatcaactgatccagtaactgtcgataataatggtaatgtcacattacattaccgt gatggctcatcgacaacgcttgatgctacaaatgtgatgacatacgaaccagttgtgaaa cctgaataccaaactgtcaatgctgctaaaacagcaacggtaacgattgctaaaggacaa tcatttagtattggtgatattaaacaatattttactttaagtaatggacaacctattcca agtggcacatttacaaatattacatctgatagaactattccaactgcacaagaagttagt caaatgaacgcaggcacgcagttataccatataactgctacaaatgcgtatcataaagat agtgaagacttctatattagtttgaaaatcatcgatgtgaaacaaccagaaggcgatcaa cgtgtatatcgtacatcaacatatgatttaactactgatgaaatctcaaaagtaaaacaa gcatttattaatgcaaatagagatgtaattacgcttgccgaaggtgatatttcagttaca aatacacctaatggtgctaatgtaagtactattacagtaaatattaataaaggtcgatta acgaaatcattcgcgtcaaac ctagctaatatgaatttcttgcgttgggttaatttccca caagattatacagtgacatggacgaatgcaaaaattgcaaacagaccaacagatggtggt ttatcatggtctgatgaccataaatctttaatttatcgttatgatgctacattaggtact caaattacgacgaatgatattttaacaatgttaaaagcaacaactacagtgcctggattg cgaaataacattactggtaatgaaaaatcacaagcagaagctggcggaagacctaacttt agaacgactggttattcacaatcaaatgcgacaactgatggtcaacgtcaatttacgttg aatggtcaagtgattcaagtgttagacatcatcaacccttcaaacggttatggtgggcaa cctgttacaaattcaaatactcgtgcaaaccatagtaactcaactgttgttaacgtaaac gaaccggcagctaatggtgctggcgcatttacaattgaccacgttgtaaaaagtaattct acacataatgcaagtgatgcagtttataaagcacagttatacttaacgccatatggtcca aaacaatatgttgaacatttaaatcaaaatacaggaaatactactgacgctattaacatt tattttgtaccaagtgacttagtgaatccaacaatttcagtaggtaattacactaatcat caagtgttctcaggtgaaacatttacaaatactattacagcgaatgataactttggtgtg caatctgtaactgtaccaaatacatcacaaattacaggtactgttgataataaccatcaa catgtttctgcaacggcaccaaatgtgacatcagcaactaataagacaatcaatttatta gcaactgatacaagcggcaatacagctacaacttcgttcaatgtaacagtgaaacctttg cgtgataaatatcgagttggtacttcatcaacggctgctaatcct gtgagaattgccaat atttcgaataatgcgacagtatcacaagctgatcaaacgacaattattaattcgttaacg tttactgaaacagtaccaaatagaagttatgcaagagcaagtgcgaatgaaatcactagt aaaacagttagtaatgtcagtcgtactggaaataatgccaatgtcacagtaactgttact tatcaagatggaacaacatcaacagtgactgtacctgtaaagcatgtcattccagaaatc gttgcacattcgcattacactgtacaaggccaagacttcccagcaggtaatggttctagt gcatcagattactttaagttatctaatggtagtgacattgcagatgcaactattacatgg gtaagtggacaagcgccaaataaagataatacacgtattggtgaagatataactgtaact gcacatatcttaattgatggcgaaacaacgccgattacgaaaacagcaacatataaagta gtaagaactgtaccgaaacatgtctttgaaacagccagaggtgttttatacccaggtgtt tcagatatgtatgatgcgaaacaatatgttaagccagtaaataattcttggtcgacaaat gcgcaacatatgaatttccaatttgttggaacatatggtcctaacaaagatgttgtaggc atatctactcgtcttattagagtgacatatgataatagacaaacagaagatttaactatt ttatctaaagttaaacctgacccacctagaattgacgcaaactctgtgacatataaagca ggtcttacaaaccaagaaattaaagttaataacgtattaaataactcgtcagtaaaatta tttaaagcagataatacaccattaaatgtcacaaatattactcatggtagcggttttagt tcggttgtgacagtaagtgacgcgttaccaaatggcggaattaaagcaaaatcttcaatt tcaatgaa caatgtgacgtatacgacgcaagacgaacatggtcaagttgttacagtaaca agaaatgaatctgttgattcaaatgacagtgcaacagtaacagtgacaccacaattacaa gcaactactgaaggcgctgtatttattaaaggtggcgacggttttgatttcggacacgta gaaagatttattcaaaacccgccacatggggcaacggttgcatggcatgatagtccagat acatggaagaatacagtcggtaacactcataaaactgcggttgtaacattacctaatggt caaggtacgcgtaatgttgaagttccagtcaaagtttatccagttgctaatgcaaaggcg ccatcacgtgatgtgaaaggtcaaaatttgactaatggaacggatgcgatgaactacatt acatttgatccaaatacaaacacaaatggtatcactgcagcatgggcaaatagacaacaa ccaaataaccaacaagcaggcgtgcaacatttaaatgtcgatgtcacatatccaggtatt tcagctgctaaacgagttcctgttactgttaatgtatatcaatttgaattccctcaaact acttatacgacaacggttggaggcactttagcaagtggtacgcaagcatcaggatatgca catatgcaaaatgctactggtttaccaacagatggatttacgtataaatggaatcgtgat actacaggtacaaatgacgcaaactggtcagctatgaataaaccgaatgtggctaaagtc gttaacgcaaaatatgacgtcatctataacggacatacttttgcaacatctttaccagcg aaatttgtagtaaaagatgtgcaaccagcgaaaccaactgtgactgaaacagcggcagga gcgattacaattgcacctggagcaaaccaaacagtgaatacacatgccggtaacgtaacg acatacgctgataaattagttattaaacgtaa tggtaacgttgtgacgacatttacacgt cgcaataatacgagtccatgggtgaaagaagcatctgcagcaactgtagcaggtattgct ggaactaataatggtattactgttgcagcaggtactttcaaccctgctgatacaattcaa gttgttgcaacgcaaggaagcggagagacagtgagtgatgagcaacgtagtgatgatttc acagttgtcgcaccacaaccgaaccaagcgactactaagatttggcaaaatggtcatatt gatatcacgcctaataatccatcaggacatttaattaatccaactcaagcaatggatatt gcttacactgaaaaagtgggtaatggtgcagaacatagtaagacaattaatgttgttcgt ggtcaaaataatcaatggacaattgcgaataagcctgactatgtaacgttagatgcacaa actggtaaagtgacgttcaatgccaatactataaaaccaaattcatcaatcacaattact ccgaaagcaggtacaggtcactcagtaagtagtaatccaagtacattaactgcaccggca gctcatactgtcaacacaactgaaattgtgaaagattatggttcaaatgtaacagcagct gaaattaacaatgcagttcaagttgctaataaacgtactgcaacgattaaaaatggcaca gcaatgcctactaatttagctggtggtagcacaacgacgattcctgtgacagtaacttac aatgatggtagtactgaagaagtacaagagtccattttcacaaaagcggataaacgtgag ttaatcacagctaaaaatcatttagatgatccagtaagcactgaaggtaaaaagccaggt acaattacgcagtacaataatgcaatgcataatgcgcaacaacaaatcaatactgcgaaa acagaagcacaacaagtgattaataatgagcgtgcaacaccacaacaagtttctga cgca ctaactaaagttcgtgcagcacaaactaagattgatcaagctaaagcattacttcaaaat aaagaagataatagccaattagtaacgtctaaaaataacttacaaagttctgtgaaccaa gtaccatcaactgctggtatgacgcaacaaagtattgataactataatgcgaagaagcgt gaagcagaaactgaaataactgcagctcaacgtgttattgacaatggcgatgcaactgca caacaaatttcagatgaaaaacatcgtgtcgataacgcattaacagcattaaaccaagcg aaacatgatttaactgcagatacacatgccttagagcaagcagtgcaacaattgaatcgc acaggtacaacgactggtaagaagccggcaagtattactgcttacaataattcgattcgt gcacttcaaagtgacttaacaagtgctaaaaatagcgctaatgctattattcaaaagcca ataagaacagtacaagaagtgcaatctgcgttaacaaatgtaaatcgtgtcaatgagcga ttaacgcaagcaattaatcaattagtacctttagctgataatagtgctttaaaaactgct aagacgaaacttgatgaagaaatcaataaatcagtaactactgatggtatgacacaatca tcaatccaagcatatgaaaatgctaaacgtgcgggtcaaacagaatcaacaaatgcacaa aatgttattaacaatggtgatgcgactgaccaacaaattgccgcagaaaaaacaaaagta gaagaaaaatataatagcttaaaacaagcaattgctggattaactccagacttggcacca ttacaaactgcaaaaactcagttgcaaaatgatattgatcagccaacgagtacgactggt atgacaagcgcatctattgcagcatttaatgaaaaactttcagcagctagaactaaaatt caagaaattgatcgtgtat tagcctcacatccagatgttgcgacaatacgtcaaaacgtg acagcagcgaatgccgctaaatcagcacttgatcaagcacgtaatggcttaacagtcgat aaagcgcctttagaaaatgcgaaaaatcaactacaatatagtattgacacgcaaacaagt acaactggtatgacacaagactctataaatgcatacaatgcgaagttaacagctgcacgt aataagattcaacaaatcaatcaagtattagcaggttcaccgactgtagaacaaattaat acaaatacgtctacagcaaatcaagctaaatctgatttagatcatgcacgtcaagcttta acaccagataaagcgccgcttcaaactgcgaaaacgcaattagaacaaagcattaatcaa ccaacggatacaacaggtatgacgaccgcttcgttaaatgcgtacaaccaaaaattacaa gcagcgcgtcaaaagttaactgaaattaatcaagtgttgaatggcaacccaactgtccaa aatatcaatgataaagtgacagaggcaaaccaagctaaggatcaattaaatacagcacgt caaggtttaacattagatagacagccagcgttaacaacattacatggtgcatctaactta aaccaagcacaacaaaataatttcacgcaacaaattaatgctgctcaaaatcatgctgcg cttgaaacaattaagtctaacattacggctttaaatactgcgatgacgaaattaaaagac agtgttgcggataataatacaattaaatcagatcaaaattacactgacgcaacaccagct aataaacaagcgtatgataatgcagttaatgcggctaaaggtgtcattggagaaacgact aatccaacgatggatgttaacacagtgaaccaaaaagcagcatctgttaaatcgacgaaa gatgctttagatggtcaacaaaacttacaacgtgcgaaaacag aagcaacaaatgcgatt acgcatgcaagtgatttaaaccaagcacaaaagaatgcattaacacaacaagtgaatagt gcacaaaacgtgcaagcagtaaatgatattaaacaaacgactcaaagcttaaatactgct atgacaggtttaaaacgtggcgttgctaatcataaccaagtcgtacaaagtgataattat gtcaacgcagatactaataagaaaaatgattacaacaatgcatacaaccatgcgaatgac attattaatggtaatgcacaacatccagttataacaccaagtgatgttaacaatgcttta tcaaatgtcacaagtaaagaacatgcattgaatggtgaagctaagttaaatgctgcgaaa caagaagcgaatactgcattaggtcatttaaacaatttaaataatgcacaacgtcaaaac ttacaatcgcaaattaatggtgcgcatcaaattgatgcagttaatacaattaagcaaaat gcaacaaacttgaatagtgcaatgggtaacttaagacaagctgttgcagataaagatcaa gtgaaacgtacagaagattatgcggatgcagatacagctaaacaaaatgcatataacagt gcagtttcaagtgccgaaacaatcattaatcaaacaacaaatccaacgatgtctgttgat gatgttaatcgtgcaacttcagctgttacttctaataaaaatgcattaaatggttatgaa aaattagcacaatctaaaacagatgctgcaagagcaattgatgcattaccacatttaaat aatgcacaaaaagcagatgttaaatctaaaattaatgctgcatcaaatattgctggcgta aatactgttaaacaacaaggtacagatttaaatacagcgatgggtaacttgcaaggtgca atcaatgatgaacaaacgacgcttaatagtcaaaactatcaagatgcgacacctagtaag aaaaca 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lnqamea lrnsiqdqqqteagskfinedkpqkdayqaavqnakdlinqtnnptldkaqveqltqavn qakdnlhgdqkladdkqhavtdlnqlnglnnpqrqalesqinnaatrgevaqklaeakal dqamqalrnsiqdqqqtesgskfinedkpqkdayqaavqnakdlinqtgnptldksqveq ltqavttakdnlhgdqklardqqqavttvnalpnlnhaqqqaltdainaaptrtevaqhv qtateldhametlknkvdqvntdkaqpnyteastdkkeavdqalqaaesitdptngsnan kdavdqvltklqekenelngnervaeaktqakqtidqlthlnadqiatakqnidqatklq piaelvdqatqlnqsmdqlqqavnehanveqtvdytqadsdkqnaykqaiadaenvlkqn ankqqvdqalqnilnakqalngdervalaktngkhdidqlnalnnaqqdgfkgridqsnd lnqiqqivdeakalnramdqlsqeitdnegrtkgstnyvnadtqvkqvydetvdkakqal dkstgqnltakqviklndavtaakkalngeerlnnrkaealqrldqlthlnnaqrqlaiq qinnaetlnkasrainratkldnamgavqqyideqhlgvisstnyinaddnlkanydnai anaaheldkvqgnaiakaeaeqlkqniidaqnalngdqnlanakdkanafvnslnglnqq qqdlahkainnadtvsdvtdivnnqidlndametlkhlvdneipnaeqtvnyqnaddnak tnfddakrlantllnsdntnvndingaiqavndaihnlngdqrlqdakdkaiqsinqala nklkeieasnatdqdkliaknkaeelansiinninkatsnqavsqvqtagnhaieqvhan eipkakidankdvdkqvqalideidrnpnltdkekqalkdrinqilqqghnginnamtke eieqakaqlaqalqdi kdlvkakedakqdvdkqvqalideidqnpnltdkekqalkdrin qilqqghxdixnamtkeaieqakerlaqalqdikdlvkakedakndidkrvqalideidq npnltdkekqalkdrinqilqqghndinnaltkeeieqakaqlaqalqdikdlvkakeda knaikalanakrdqinsnpdltpeqkakalkeideaekralqnvenaqtidqlnrglnlg lddirnthvwevdeqpavneifeatpeqilvngelivhrddiiteqdilahinlidqlsa evidtpstatisdsltakvevtlldgskvivnvpvkvvekelsvvkqqaiesienaaqqk ineinnsvtltleqkeaaiaevnklkqqaidhvnnapdvhsveeiqqqeqahieqfnpeq ftieqaksnaiksiedaiqhmideikartdltdkekqeaiaklnqlkeqaiqaiqraqsi deiseqleqfkaqmkaanptakelakrkqeaisrikdfsnekinsirnseigtadekqaa mnqineivletirdinnahtlqqveaalnngiarisavqivtsdrakqssstgnesnshl tigygtanhpfnsstighkkkldedddidplhmrhfsnnfgnviknaigvvgisgllasf wffiakrrrkedeeeeleirdnnkdsiketlddtkhlpllfakrrrkedeedvtveekds lnngesldkvkhtpfflpkrrrkedeedvevtnentdekvlkdnehspllfakrrkdkee dvetttsieskdedvplllakkknqkdnqskdkksaskntskkvaakkkkkkakknkk 441. atgttctttgatgatgctaaagaagcatcaagagtacttgaaataacattgacgaaaaga gatgctaaaaaagaaaatcctattccgatgtgtggcgtaccatatcattctgctgataat tacattgaaacattgattaataaggggtataaggtcg ctatatgtgaacaaatggaagat ccaaagcaaacaaaaggaatggttagaagagaagttgtaagaatcatcacaccaggaact gttatggatcaaaatggtatggatgaaaagaaaaataattatattttaagttttatcgaa aatgaagaatttggattatgctattgtgatgtttctacaggagaactcaaagtaactcat ttcaaagatacagcaaccttgcttaatgagattacaacaattaatcccaatgaaatcgtc ataaagcaagctctatctgaagaattaaaaagacaaatcaacatgataactgagacgatt actgttcgcgaagatatatctgatgaagattatgatatgaatcagttgacacatcagtta atgcatgacacaactcaattattgttagattacattcatcacacacaaaagcgagattta tctcatattgaggaagtaattgaatatgctgcagttgattatatgaagatggattattat gcgaagcgaaatttagagctgacagagagcatacgattaaaatcaaaaaaagggactttg ttatggttaatggatgagacaaaaacaccgatgggtgctagacgtttaaagcagtggatt gatcgtccattaattaataaacaacaaatcaacgacagattaaatattgttgaagagttt atggaccgttttattgaaagagatacattacgtaatcatttaaatcaagtgtatgacata gaacgactagtaggaagagtgagttatggaaacgtaaatgcaagagatttaatacaactt aagcattctatatccgaaatacctcacattaaagcattactcaatgaattgggtgcacaa actaccacgcaatttaaagaattagaacctttagatgacttgttacaaattttagaagaa agtttagttgaagaaccacctatttccatcaaagatggaggattatttaaaaatggcttc aacgcgcaacttgatgaatatttagaagcttcaaaaaatggtaaaacttggcttgcagaa ttacaagctaaggaacgtgaacgtacaggtattaagtcattgaaaattagttttaataaa gtgtttggttattttattgaaattacacgtgcaaacttaaataattttcaacctgaagcg tttggctataatcgaaaacaaacattatctaatgctgaacgatttattacggatgaatta aaagaaaaagaagatataatacttggtgctgaagataaagcagtagagttagaatatgaa ttatttgttaaattacgagaacacattaaaacgtacactgaacgtttacaaaagcaagcg aaaatcatttcagaacttgattgtttacaaagttttgctgaaattgctcaaaaatataat tatgtcaaacctacatttagtgatgataaagttttacatttagaaaactcaagacatcct gttgttgagagagtgatggattataatgattatgtacctaatgattgccatcttgatgat gaaacgtttatttatctcattacgggacctaatatgtcaggtaagtcaacatatatgaga caagttgctataataagtatcatggctcaaatgggagcatatgtaccatgtgattcagca acattacctatatttgatcaaatttttactaggattggtgcagcagatgatcttgtatca ggtaaaagtacatttatggtagaaatgttagaagctcaaaaagctttaacttatgctact gaaaatagtttaattatctttgacgaaataggaagaggtacatccacttatgatggtctt gcgttagcgcaagcgatgattgaatatgttgctcaaacttcccatgctaagacacttttc tcaacacattatcatgaattgacatcacttgatcaaatgcttaagtgtttaaaaaatgta catgttgctgcaaacgagtatcaa ggtgaactgatatttttgcataaagtcaaagatggc gctgtggatgatagctatggtattcaagtggcaaaattagcggatttacctaatgaagtc attgatagagcgcaagttatattaaatgcatttgagcaaaaaccttcgtatcaactctct catgagaatactgacaatcaacaaacggttccgtcgtataacgattttggtcgaacagaa gaagagcaatcagttatagaaacacatacatcaaatcataattatgagcaagcgaccttt gatttatttgatggttacaatcaacaaagtgaagttgaatgtcaaattcgagaattgaat ctatccaatatgacaccattggaagccttaatcaagctgaatgaattacaaagtcaatta aag 442. mffddakeasrvleitltkrdakkenpipmcgvpyhsadnyietlinkgykvaiceqmed pkqtkgmvrrevvriitpgtvmdqngmdekknnyilsfieneefglcycdvstgelkvth fkdtatllneittinpneivikqalseelkrqinmitetitvredisdedydmnqlthql mhdttqllldyihhtqkrdlshieevieyaavdymkmdyyakrnleltesirlkskkgtl lwlmdetktpmgarrlkqwidrplinkqqindrlniveefmdrfierdtlrnhlnqvydi erlvgrvsygnvnardliqlkhsiseiphikallnelgaqtttqfkeleplddllqilee slveeppisikdgglfkngfnaqldeyleaskngktwlaelqakerertgikslkisfnk vfgyfieitranlnnfqpeafgynrkqtlsnaerfitdelkekediilgaedkaveleye lfvklrehiktyterlqkqakiiseldclqsfaeiaqkynyvkptfsddkvlhlensrhp vvervmdyndyvpndchlddetfiylitgpnmsgkstym rqvaiisimaqmgayvpcdsa tlpifdqiftrigaaddlvsgkstfmvemleaqkaltyatensliifdeigrgtstydgl alaqamieyvaqtshaktlfsthyheltsldqmlkclknvhvaaneyqgeliflhkvkdg avddsygiqvakladlpnevidraqvilnafeqkpsyqlshentdnqqtvpsyndfgrte eeqsviethtsnhnyeqatfdlfdgynqqsevecqirelnlsnmtplealiklnelqsqlk 443. atgattccaactaaacctcatgatgtgatttggacagatgcacaatggcaaagtatttat gcgaaaggacaggacatacttgttgctgctgcagcaggttccggtaaaacagccgttcta gttgagcgtattatacaacgtatactaagagatgatgtagatgtagatcggttactagtt gtaacatttacgaatttaagcgcacgtgagatgaagcatcgagttgataaacgtatacaa gaagcatcttttaaggatcctaacaatgaacatttaaagaatcagcgaatcaaaattcat caagcacagatttctactttacacagtttctgtttgaaattgattcagcagcattatgat gtattagatatcgatcctcattttagaacaagtagtgaagcggaaaatatattattatta gaacaaactattgatgatgttttagaacaacactatgataaattagatcctcactttata gaattaaccgaacaactatcatcagataggaatgatgatcaatttagaagtattattaag cagttatattttttcagtattgctaatcctcaaccatttgaatggctcaatcaattagcg caaccatacaaagaagaaaataaacagcaacaattaatgcagcttatcaatgatttagca atgatttttatgaaagcaggatatgaggaattacaaaaaagttatgacttattctca atg atggaaagtgttgataagcagcttgaagttattgaaaccgaacgcatgtttattactaaa gctattgaaggtaaagtattaaatacagatgttatcacgcaacatgaatttatgagtcgt tttccggcaataaatagcaagataaaagaagcaaatgaaggcatggaagatgctttaaat gaagcaaaacaacattatgataaatataaatctttagttatgaaagtaaagaatgattat ttttctagaaatgcagaagatttgcaaagagatatgcaacaactcgcacctcgagtggct tatttagctcaaatagttcaagatgtgattcaatcatttggtgttcaaaaacgaagtcgt aatattttggatttttcagattatgaacattttgcattacgcattcttactaacgaagat ggctcaccttcgcgtatcgctgaaacgtatcgtgaacattttaaagaaatcctagttgat gagtatcaagatactaatagagtgcaagaaaaaatattatcttgtattaaaactggtgaa gaacacgatggtaacttgttcatggttggggatgtgaagcagtctatttataaatttaga caagctgatcctagtttatttattgaaaaatataatcgcttttctagtagtggaaatgaa agtggcttgcgcattgacttatcgcaaaactttcgttcgagacaggaagtgttatctaca accaattacttgttcaaacatatgatggatgaacaagtaggagaaatttcatatgatgat gcagcgcaattgtattttggtgcaccatatgacgaagtttcacatcctgttcaattacga gcacttgttgaggcaagttcagaaaatagtgacttaactggaagtgaacaagaagcgaat tacattgttgaacaagttaaagatattattaatcatcaaaacgtatacgatatgaaaaca ggtcaatacagaaaagcaac atataaagatatcgtaattttagagcgaagttttggtcaa gcgcgtaatcttcaacaagcttttaaaaataatgatatcccttttcacgtaaatagtaag gaagggtattttgagcaaactgaagtacgtcttgtgctttcatttttaagaacaatagat aatccacttcaagacatttatttagtgggattgatgcgttctgtaatatatcaatttact gaagaagaattagctgaaataagagttgtaagccctcatgatgattacttttatcaatct ataaaaaattatatgattgatgaaaaagctgattctagattggttgacaagttaaatcgt tttattcaggatatacaaaaatatcaaaattatagtcaaagtcaaccggtttaccaatta attgataaattttataatgatcattttgtaattcagtactttagcggtcttattggaggt aaaggtagaagagcaaatctgtatgggctatttaataaagctgttgaatttgaaaattca agtttcagaggtttattccaatttattcgttttattgatgagcttattgatcgtaaaaaa gattttggtgaagaaaatgtcgtaggtcctaacgataatgtggttagaatgatgacgatt cacagtagtaaaggattagaatttccatttgtaatttactcaggattatctaaaaaattc aacaaaggtgacctgaatgcaccagttattctaaatcaacaatatggtttaggtatggat tattttgatgtaaataaagatatggcttttccttcacttgcctctgtggcatatagagca ataaatgaaaaagaacttatatcagaagagatgcgtttaatctatgttgcgttgacacga gcaaaagagcaacttattttagttggaagagtcaaagatgaaaagtcgttaattaaatat gaacaattagctgtttcagacacacatatagcagttaatgaacg ccttactgctaccaat ccatttgttctaatttatggtgttttggctaagcatcaatcgccttcattgccaaatgat caaagatttgaaagagatattgatcaattaaattctgaagtgaagccacgtgtatcaata gtgattgatcattatgaggatgtttcaactgaagaagtagtcaatgataatgaaataaga acaatcgaagaattaaaggccataaatactggtaatgaagatgtgaaaattaaaattcat caacagctttcttatgactatccttttaaagttaacacgatgaaaccatctaaacagtcg gtatcagagttaaaacgtcaattagaaactgaagaaagtaatacaaattatgatagagta cgtcaatatcgtattggtgttgcatcatatgaaagacccaagtttcttacccaaacaaaa aaaagaaaagcaaatgaaatagggactttaatgcatacagtcatgcaacacttacctttt agagaacaacgtttaacaaaagacgaattatttcaatatatcgatcgattgattgacaaa caacttattgatgaagatgcaaaagaggatattagaatagatgagattatgcatttcatt gatggccctctctatatggaaatagctcaagctgacaatgtttatactgaattacctttt gtggtaaatcaaattaaagttgatggacttacaagtgaagatgaagatgtatccattatt caaggtatgattgatttaatatatgaaagtgacggacaattttactttgttgattacaaa acagatgcttttaatagaagaaaaggtatgagtgatgaagaaatagggaatcagctcaaa gaaaaatatcagatacaaatgacgtattatcgaaatactttagaaaccatacttaaacga cccgtaaagggttacttatattttttcaaatttggtacattagaaatagatgat 444. miptkphd viwtdaqwqsiyakgqdilvaaaagsgktavlveriiqrilrddvdvdrllv vtftnlsaremkhrvdkriqeasfkdpnnehlknqrikihqaqistlhsfclkliqqhyd vldidphfrtsseaenillleqtiddvleqhydkldphfielteqlssdrnddqfrsiik qlyffsianpqpfewlnqlaqpykeenkqqqlmqlindlamifmkagyeelqksydlfsm mesvdkqlevietermfitkaiegkvlntdvitqhefmsrfpainskikeanegmedaln eakqhydkykslvmkvkndyfsrnaedlqrdmqqlaprvaylaqivqdviqsfgvqkrsr nildfsdyehfalriltnedgspsriaetyrehfkeilvdeyqdtnrvqekilsciktge ehdgnlfmvgdvkqsiykfrqadpslfiekynrfsssgnesglridlsqnfrsrqevlst tnylfkhmmdeqvgeisyddaaqlyfgapydevshpvqlralveassensdltgseqean yiveqvkdiinhqnvydmktgqyrkatykdivilersfgqarnlqqafknndipfhvnsk egyfeqtevrlvlsflrtidnplqdiylvglmrsviyqfteeelaeirvvsphddyfyqs iknymidekadsrlvdklnrfiqdiqkyqnysqsqpvyqlidkfyndhfviqyfsgligg kgrranlyglfnkavefenssfrglfqfirfidelidrkkdfgeenvvgpndnvvrmmti hsskglefpfviysglskkfnkgdlnapvilnqqyglgmdyfdvnkdmafpslasvayra inekeliseemrliyvaltrakeqlilvgrvkdekslikyeqlavsdthiavnerltatn pfvliygvlakhqspslpndqrferdidqlnsevkprvsividhyedvsteevvndneir tieelkaintgnedvkikihqqlsydypfkvn tmkpskqsvselkrqleteesntnydrv rqyrigvasyerpkfltqtkkrkaneigtlmhtvmqhlpfreqrltkdelfqyidrlidk qlidedakedirideimhfidgplymeiaqadnvytelpfvvnqikvdgltsededvsii qgmidliyesdgqfyfvdyktdafnrrkgmsdeeignqlkekyqiqmtyyrntletilkr pvkgylyffkfgtleidd 445. ctgtaccatcaaatggtgctacaatttctcctgaatctggtacaaatccgataccatcac ccatcatcttttcagagaaaactttatcaggtacttcagataacggtattatctcaccat gtccaggtgcgtaaatttctgtttctacaatatcttccacatgtacaggatcatctgaca cttcttcatcaattgttgtttcacttggttttg 446. lyhqmvlqfllnlvqiryhhpssfqrklyqvlqitvlshhvqvrkflflqylphvqdhlt llhqllfhlvl 447. cgcatactttggtcatcactatgcgtaatccacaaaatggcaatccctttatctgctagt ttaaatataatttcttcaattttctttttattatgtgtatctaaagcgctagtagcttcg tccaataataaaacttcaggttcatacatgagttgtctagcgatggtaatacgttgttgc tctcccccagacatgtgctcaatt 448. rilwsslcvihkmaiplsaslniissiffllcvskalvassnnktsgsymsclamvircc sppdmcsi 449. tcacgtactttacgcgctctactcttaatactccaaacaggcatgatgtgtggtttgtta tggtcatcatctgaaatcataataaaattcttttcacctttgtttgtcaatccgtatact tcgtcatattttgcgacatctttaataaactctctcattcttatatcatctaat tcagac atcaactcatcagtcattttaactatatctacaatgtttccttcttcaccattattcaca ttaactaaaactttgtcacctggatcaaagatttcatccatttcatatgttacaaaacgg tcaatatctgctctaatgattttgtcg 450. srtlralllilqtgmmcgllwssseiiikffsplfvnpytssyfatslinslilissnsd inssviltistmfpssplftltktlspgskissisyvtkrsisalmils 451. gcaggatttttgactaaagcagtacttaaatcaacttcatctctgtcatcaaacacttct tctacgacttctttacgtgcaatcactctaaatgaaccttcgtccatatttaattctact cttacatttctggcactatca 452. agfltkavlkstsslssntssttslraitlnepssifnstltflals 453. tatttctttataagctttttaattagactaatatcatgctcattgattaccgaaacaatt tcgatttgtccatttttagatataattgagccattaccaccaatcaaggtatcatccgca aattcaggaatgactggaagcaagtctctaatgggacgtgctgatgcaaacattacattg 454. yffisflirliscslitetisicpfldiieplppikvssansgmtgskslmgradanitl 455. ttatcttcttctaaagctttaccttcaacgtcaacgtttggcaatactgcacctaaccat ttaggaaggtaccatgaagctttaccaaagagtttcgtcaatgctggaattaatgtcata cgtacgacgaatgcgtcgaataacacaccgaaacctaatgcgatacccattgacttaatt gcactgtcatcttggaagacgaatgcgatgaatacactgaacataataagtgcagcagct acgataacaggtccactttctt tgatacctacacggattgaa 456. lssskalpststfgntapnhlgryhealpksfvnaginvirttnasnntpkpnaipidli alsswktnamntlniisaaatitgplsliptrie 457. tcatcaactgcttgcattaagtctaagattttttgttcgtattcagcatcgccttctaat gcttttaatgcagaaccagcgattacaggtacatcgtcacctgggaagtcatattcgctt aataagtcacgaacttccatttcaactaattctaataattcttcgtcgtctaccatgtca actttgtttaagaatacaactaatgctggtacaccaacgttacgtgataataagatgtgt tcacgagtttgtggcattggaccgtcagcagcagatacaactaagataccgccgtccatt tga 458. sstacikskifcsysaspsnafnaepaitgtsspgksyslnksrtsistnsnnsssstms tlfknttnagtptlrdnkmcsrvcgigpsaadttkippsi 459. ttagaaccacctacacgacgagctttaacttctaatactggcatgatattattaattgct tcttcgaacacttctaatgcatcacgaccactacgttgttcaacaagatcaaatgcagaa 460. lepptrraltsntgmilliassntsnasrplrcstrsnae 461. aggaggcgaccgccccagtcaaactgcccgcctgacactgtctcccaccacgataagtgg tgcgggttagaaagccaacacagc 462. rrrppqsncppdtvshhdkwcglesqhs 463. tgtgctattattccccctattgaaggacctaacccttcacctaaagctacaattgatcct ataaaaccaaaggctttgccttgtttttttcttgtaatatttctagctacaaccaccata atcagtgaagggaatgcagcagatcctactcc ttgtactaacctaccaaaaatcaaaata aaaaag 464. gccagtcacttctcgttccatttgattcaatacaaacaaattatcttgaacatcttccga agcactgtcgccagtatcttgcttttcttttgcttgttgtttatgatttattttcgcacg gtcaaattttttcttaactttctcattattaatgatttttgcttttacatggcattcaac cggaaaaggcatattttgagctttctcaaa 465. tgtcgtattaatactgccttcaccagtattgctagcatttggatcttgagtttgtgcgtt tgctgctacaggtgctgctggttgcgctgctgctggagcattcgctggctgtgtttgatt tgccggtgttgcattattattaggtgttgcttggttatttccttgacctgcttggtttgc cggtgttgcttgatttccaggttgtgcttgtgcagcgttattcggatcagcttgattacc ttgtccagctggttgtgtatttggttgtgctgctcctcctgctggattagcctgtccacc ttggtttgctggttgtactgctggttgtccttggttggcaggtgcagctggctgtgctgt aggattagcttgagcaccagcatttgcgttaggctgtgtattggcatcagctggttgtgc tggttgattttgtgcaggctgattttgctctgctgcagacgctgttgtcgggttagtaga tataaaagtaacagtggcaat 466. atccaacgtttcaggaataaatgttttcaaaccactttgaaatggatcgcggtgttgtgc ttgatatactttgtagcgataacgtttacctacacaatcataacgacaatgaaaatcgtc atcgactgtaactacattgttgacataaatatcatcagg 467. cggtataaaggtaaagcaaaatgcatcagcttgcttagaatgattgtcctttttttga ta atagcgttccattgcaatgacggcagaaggatggtttgcaaacaaatgatttgtatattc actttc 468. atgcaagagtaccaaaaatcgttaaatacgcttaaaaagcctataaatgttccgtatgag caagaaactgaaaaagtaggtggtttatttagcaaagaaatacaagaaactggaaatgtt gtaataagccaaaaagatttcaatgaatttcagaaacagataaaagctgctcaagatatt tcggaagattacgagtatataaagtctggtagagccttagatgataaagataaggaaata cgagagaaagatgatttattaaataaagcagttgagcgtattgaaaacgcagacgataat tttaaccaactttacgaaaatgcaaagccacttaaagagaatatagaaatagcgttaaag cttttaaaaatcttactaaaagagttagaacgagttttaggaagaaatacctttgcggaa agagttaataagttaacagaagatgaaccaaaactaaatggtttagcaggaaacttagat aaaaaaatgaatccagaattatattcagaacaggaacagcaacaagaacaacaaaagaat caaaaacgagatagaggtatgcactta 469. atgctaactactttcgctgttgtactcattttcttcttacttccatcttcatttttattg 470. ttgagcatctgcatcattattatcattcatgcgatcatttttgttcacattattaaaaat ggcattcaaaataacaat 471. ttgcctataccaagtactagaagtgcaccaataattccagcaatcaatgcaacgatgact gttttaaaccatggaaatttaggtcttctgtatctaggtgtttggctatggtttgttgta gaa 472. atgcttttgagttacttcataatactcatcagttttttgtgtatccttttgacttttatt tatttctttccacttaccagtatgactttctttttttacagttattttcggtttgtt 473. atgacttgtgaaaaactggaaaatttcttgaccagtagcaaagccggcaccaacgacaac accaacaaaggcaaatgccacaataatggactcttt 474. ttgattgtcattagtaacgttattgccattattttgatttttatctgttttgtctgcact atcatcttgttgatcattttcttcggtttctgtctttttatgcgtagatttattttcttg ttcttggttattact 475. atgtgcagaaattgcccagcattcaccagttgtttcattagggatatcatagttaaatgc ttt 476. gtggtatacaacgcaacgtatatgcatcttgtacacgtatttctgattgtcgcgtcgtta atgttgatccttctaaccaatcacgcatacgcgctgccacat 477. gtgacaaatatcacactaaacagtgcatttgcagatgctacgataagcgtatttttatac caagtcaggtat 478. ttgtgcagtagtagcttggttactattcttaagcttttgttctgcatctctcaactgttt aagtttttgatacgcatcttgtttacgttgatttgtacgtttatattgattttcagcttt tttaagttctgtattcga 479. ttgccttcttgtttatattgttcaacaagtgctttatgcttagcggactgcttctgtact gcgtcacttgctctttttagttgtgcagtagtagcttggttactattcttaagcttttgt tctgcatctctcaactgtttaagtttt 480. caiippiegpnpspkatidpikpkalpcfflviflatttiisegnaadptpctnlpkiki kk 481. ashfsfhliqykqiilnifrstvasillffcllfmiyfrtvkfflnfliindfcfymafn r krhilsflk 482. crintaftsiasiwilslcvccyrccwlrccwsirwlclicrcciiircclvisltclvc rcclisrlclcsvirislitlsswlciwlccsscwislstlvcwlycwlslvgrcswlcc rislstsicvrlcigiswlcwlilcrlillccrrccrvsryksnsgn 483. iqrfrnkcfqttlkwiavlcliyfvaitftytiittmkividcnyivdiniir 484. rykgkakcisllrmivlfliiafhcndgrrmvckqmiciftf 485. mqeyqkslntlkkpinvpyeqetekvgglfskeiqetgnvvisqkdfnefqkqikaaqdi sedyeyiksgralddkdkeirekddllnkaverienaddnfnqlyenakplkenieialk llkillkelervlgrntfaervnkltedepklnglagnldkkmnpelyseqeqqqeqqkn qkrdrgmhl 486. mlttfavvliffllpssfll 487. lsiciiiiihaiifvhiikngiqnnn 488. lpipstrsapiipainatmtvlnhgnlgllylgvwlwfvve 489. mllsyfiilisflcilltfiyffpltsmtfffysyfrfv 490. mtceklenfltsskagtndntnkgkchnnglf 491. livisnviaiilificfvctiilliiffgfclfmrrfiflflvit 492. mcrncpaftscfirdiivkcf 493. vvynatymhlvhvflivaslmlilltnhayalph 494. vtnitlnsafadatisvflyqvry 495. lcssslvtilkllfcisqlfkflirilftlictfilifsffkfcir 496. lpsclycstsalcladcfctaslalfscavvawllflsfcsaslnclsf 497. caagtgctgaaaatgcttcagaacatcctcttgctgatgctattgttacttatgctaaag a taaaggtcttaatttacttgataatgacacttttaaatcaattccgggacatggtatta aagctacgattcatcaacaacaaatccttgtgggcaatcgaaaat 498. aagaggcttgttatgcagcaacacctgcaattcaacttgccaaagattatcttgctcaac gccctaacgaaaaggttcttgtcattgctagtgacacagctcgttatggtattcattctg gtggtgagcctactcaaggtgccggtgcagttgcaa 499. ctgcgcctacgccagtttcagctattatgcacgctggtattgttaatgctggtggcgtta ttcttacacgcttttctccggtatttaatgacgaaa 500. cgtttacgatatacttcatacatcattaaacttgcagccacagacgcgttcaagctattg acatgtccaaccattggaatcttaata 501. tcaagcgtttttgctatacgacttactatcactttttctcgattttcaaatgttggatgc aaaaaacatatcaagggagccataataatgaagaaagaaataatagaatggattgtagcc ataatcgttgcaattgttatcgtcacacttgtgcaaaagtttttatttgcttcttataca gtcaaaggagcatctaatgtcatttatcac 502. agatctgtaccacatattgtcgtcttaactatgcgaataatagcgtcagtactgctcgta atagttggcttctctttatccgtaagttgtgca 503. actgccaataatatcatcagcttcataattacgcttaccaacatttacaaaaccaaactg atgggatatttctttaacataatcgaattgaggaataagttcatcaggaggtgctgggcg attttgtttatagccatcatacatttcatttctgaatgtttcttgccccatatcccaaca aactgctacgtgagtaggttcgattt ccttgatagcgctaaaaatatgtcttacaaaacc ttgaataccatttgtaggaattcctttagaattgtacataaattgattgtg 504. ttcttttgtagattgactcaactcaactggctcaaatacttgtccgttagaatgctttac atgtattttatgattttcagtataatgaatcatattgtaagtaccatttgt 505. atttttatatctacatgcgggtgtagtacaacatcagcttggaaggctgaggttttgcca ttaagggttcgattcccatcacccgctccattt 506. ctaaagaatatattgaggattgtatttattgctggtttgacagttttcttctctggtcct ggccaaacttattcaaacgcagcatttattgatgaatatattcaaacatttggatggagc cgtacagaagtt 507. aggaattccaatcaaatgtaccaaacatttacagcggatattgtacttatatttatgatt attgtacttggaggacttgtagttcaagttccaatgccaattttagcaggtattatggtt atggtttctgagacaatctactgtttgcacctgat 508. aatcaacgactcgaggaaacaatttcctctccccatcacagctcagcctta 509. atgaaacaatttttaaacatcactcaacgtaaatttatcgaatggttgattatcttatcc atttttatagttagcattcctaataaatggacattaatgatatctatcgctttatcttta ttacttcttaaaagaggggcgctaggtgtcgttcaattaatcatactttatatgctcaga tcgcaaatatacaccccatatgatacacaagagatggcgcattacatagtaagtatgaaa tatatcttgatttatgtaattggagtattttttctatttaaatatgtaaaacattggata agaaatgaaatgatattaagattta tcaagtctactatgattcttatgctactttatatc ataatgagtttagtcgtatctaatgatccgatagaatctattcttaaattgcttaacttc tttataccgctaattttgattgttatgtatgttagtttaataaaaaagataaagaatctc attaactggattaatcaatttatcacgctagtgattgcctttacttttttatttatagtt atagcgccaaaatcatatttaattgatgaggaatcacttagaagtgttttcaaggatgca cattcattcgcagttattcttgctatgggtctagttctatatatggtaacaataatcaaa caacaagattatgatgtattcaatttattattattaaatattggaatgatagagctctat ttatcaaattctcgtcatattttcatatctgttattttatgtctaatgcttctattaccg ttatctcacataaaaaagagaattaaacatcccataattggtgctatgatactaatggca attgctataataaatcaaccatatatttatcatctttttattaaactaatcttaaaaggg aagaatagccaagaggtctttatgccgagtgatatgaatattaaagctattgattatgcg ctaactgagcatccttttttaggaagcggttttggtataccaatgataaaagcgagttca gaaatacaatactttaatgtagcaacgagtaatatcatcttcggtatgattatctttact ggaataataggacttactttatgtacgatatacatgcttcatatggtacttttagttact tttccaatgagtattactattttattatttttaatcactatctttgttaatatggattat attattttatttgattccgtggggctaggtatattgtgttatatattttggggaatatat ttaaaagaaggtatgtatcaatacaacaacggacaatgg 510. atga caaatcaaaaaactgtgggtctagtcgtcgctccaggtgttactgaacgccttgca gaaaatctcatacaagaaatgcctaaaatgttatctacacattatgatcatcagcaagaa tggatttttgatttagttacggatccgcttactggttttgctgaatctgtagatgaaatt tttgggaaagtagccgattatcacgataagagacaatgggattatgtgatagcaattaca gatttaccgatgtttgcggacaagcaagtgatggcattagatattaatatggaaaatggt gcagctatattctcatatccggcatttggctggcgtccagttaaaaaacgtttcaagcat gcgatttataatattattcaagaattaaatgaagctgaacaagaaagtcgtaattatgat aataataagcaaatagaaaattcagtaaaaaaacaatttccgctctctaaaatagataaa gaaacaatatatatgaaagaaacagactcttatcacttaagatatttatcaagttcacgt tctagaggcatgtttcgccttgttagtggaatgacctttgcgaataatccattaaatatg atggcaagtttaagtaatatagtagctattgcatttactacaggtgcatttggacttgta tttacaacgatgtggcaaatggcttataacttttcaatgtggcgcttatttggaatttca attattgcgattattggaatgctaatatggataatgatgtcacatgatttatgggagcca gttaataaaagcaaccataagcatattacttggttatacaatcttacaacaataatgaca ttgatttttgccattataatttattatattattctttatttactattcttaattgctgaa atcgtattattgccatcaggattcttaggtcagcaagttggattgaaaggtcctgcaggc attgatttgtatttaagtattccatggt ttgcagcttcaatttctacagttgcaggtgca ataggtgctggtttacttaatgatgaactcattaaagaaagcacatatggatatcgtcag cgtgtaagatacgaagaacaacgtcga 511. atgaaattctgccctcattgtggaaatccgataaaaaaggaacagtcattttgtaataaa tgtggaaaacatttaaagacatcgacacaaagaaaaagtgaaaatcaaattgaacatatg cgtgaacagcaatcgtatatttctcgtgaggaaagacaacatcatgattcaacattttat aaagaacaaaaacatactggttggctaattgtattatcaattatatttgtcttgttgata gcagcgctattgtatggtgcgtactatgcttacaatcattatattagtgatgagcaaagt caccaaacaacagagtctcagcaatcaaatgaaagtgatcaaaatagggaccaatccact ggtccaagcattgatgtttttagtgatgactttgatcaaggttatatgaagtcagcttca acaagtggatatagaggtgtttataatggaatgacacgtgaagaagttgaagataaattt ggaacatccaatggttctgtagaaagtttgaagtggagttacgaaacatatggtgattta gctgtagcctacgatgataatgaagttgttagcgtaggtgtagcacctaatcatatttca gaagatcaatttttaagtatgtataatgaaccggatgatagaaattcaagccaactcatt tatgatagtaacaaagataatgacttctctgtgttagctaatgttaaaaatggagatgtt actgtcattgaaaatgtaaatcaaatt 512. atgttattgtttatcatagaaatcataatcatgattctagcgatattattaggattaaga actgctggtgcactgggatgtggcatctttgctatagtagcgcagct tatcatgatattt ggattccagttacctccaggttcagcaccagtgacggcagtgttaatcatattatctatt ggtatagcaggtggtacgttacaagccactggtggtattgactatttagtatacattgca tcacgtgtgattgaacgctttccaaaatcaattatatttatagcgccaatgattgtcttt gtctttgtttttggaattggtactgcaaatatagctctttcacttgaacctatcatagcg aaaactgcacaaaaagcacgaattcagcctaaacgcgcattaactgcttcggtacttaca gccaatttagccttactttgtagcccggcagcttctgctacagcttatattatttctgta ttagcagggtatgaaatatcgatgggcaagtatttaagtattgttttacctacagcttta attagtatgttaatgcttagtacattttgtacatttgtaggacgaaaagaacacgtgcgt gatgagtcagaacgtttagttcagatgccagaagtcgaaatcaaaaatgacttttcatta aaagtaaaaataggtgttatctcattcctattatgtgtcatgggtattttaacgtttggc atatttcctaatctcatgccgcaattcaatgtgaatggagatgtagttaaagttgagatg actgaaattgttcagttctttatgtatctcagcgctacaatcaatttattattaataaaa atcaatacttctgatattctgtcatcgaatattacacaatctgcaatgggagcacttttt gcagttcttggcccaggttggttaggtgcaacaatatttaatgctccacataacttaaaa atattgaaaaatgatattgggtcaattattagtgaagtaccttggcttgttatcatactt gtttctgtagttgcaatgattgtcatttctcaaacagctacagcatcaattatggtgccg atagttatga gtttaggtatacctcccatctattttgttgcgatggtacaaacattaaat gtgaatttcgttattccagctcaaccgacactattatttgctgtagaactagatgaaaca ggtagaacaagacctacgagctttatgataccaggattttttgttataacagtatccgtc attacaggatttgttattaaaaccattttaggatat 513. atgggaagtttttttaatcggatgactcgaaaagagaatcctactatttatcaaaataaa gatgggcatcttaagcgcacgttacgtgtacgtgactttcttgcactaggtgttggtaca attgtctctacatctatcttcactttaccaggtgttgtcgcggctgagcatgccggacct gctgtggcattatcattcttattagctgccattgttgcaggtcttgtagcctttacttat gcagaaatggcatctacaatgccttttgctggatcagcttattcatggattaatgtactt tttggtgaattattcggatgggttgccggttgggcgcttttagcagaatactttattgct gttgctttcgttgcttcaggcttttctgctaacttaagaggtcttattgcaccattaggc atttctttacctaaatcattatctaatccatttggaagtaacggtggtgtcattgatatc attgctgctgtagtgattattttaactgcattactattatcacgcggaatgaacgaagcc gctcgtatggaaaatgtattggttatattaaaggtgttagccatcattttatttgtgatt gttgggctaactgcgattaatttcagtaactatataccatttattccagaacataaggtt actgaaactggcgactttggaggttggcaaggtatttatgctggagtttcaatgattttc ttagcttatattggttttgactctattgctgctaattcagctgaagcgattaa tccacag aagacaatgcctagaggaattttagggtcactcatagtagcaattgtattgtttgtggcc gtagcacttgttcttgttggcatgttccactactctcaatacgctgataatgcagagcca gtaggttgggcattacgagaaagtggtcatggtattattgctgcaattgttcaagcaatt tctgtcatcggtatgttcactgcattaatcggtatgatgcttgcaggttcacgtctatta tattcatttggacgagatggtttactcccttcttggttaagtcaattgaatcacaaacat ttacctaatcgagcacttgtcatacttacaatcattggcgtagttatcggatcaatgttc ccgtttgctttcttagcacaattgatttccgcaggtacccttgttgcattcatgtttgtg tcactagcaatgtatcgattaagaaaacgtgaagggaaagatttacctaagccagagttt aaattacctttatatcctattttgcctgcaattacatttatattagtattgctagtattt tggggattaagttttgaagctaagttgtatacactgatatggtttattgtaggtataatt atttatttaatttatggaattagacattccaaaaagaatgatgaagaagcgtatcaagta cctagagaa 514. atgacaaagaaaaaacgtttatcgcctagtgagtggttgcttaaacaatctaaaagacat aaaaggaaaaatacactttacacggcaattgtacttttagtagcgttagttctactcata tttgctgttaaatcaatacaagtagaacctgtaaaaagtgatacgagagacaaagatagc attcgtatcacctatttaggtaacgtcactttaaataaacatattcgacaaactaacttg aatgatgtttttaaaggtattcaagatactttagatcatagtgatttttcaacaggttca t taatagtaaatgatttttcaagaaatcaaaaagataacataaataaaaatattgaaaat atcatgtttctacgcaagcataatgttaaaagtgttaacttaatcaacgaatctatggat aatattcaagcgacagcaatgatgagaaaaatagattcccaagcaggttataatttttta acaggtaatggttcaaatccaattaatagtaaaactgtacaacaagacattaaaggtaaa aaaatagctaatgtttcatttaccgatatcgaatctaactatactaactctttaaaaaac acgacgtcaattagtttagatccagctatattttatcctttaataaaaaaattaaaggaa aataatgattacgtcgtagtcaatgtagattgggggatacctaatgaacgaaatgtgact acacgtcaaaaagaatatgcacatgcgttagcgaatgctggtgcagatgtcattattggt cataatacagttattcaaaaagttgaaaattataagcgaacgcctattttttatagttta ggtaacacaacgtctgataacttcttatcaaaaaatcagaaaggaatgattgtacaacaa gactggaaaggttcgcataatcagttccatatcacaccaattcaatcaaaagatggaaaa atctctaaagataatatgaataaaatggatcatattcgattcaaaaataacattaaagat aaatcaattgatttaaaatctgatcaaaatggaggttatacttttgaatat 515. atgattgaacatttaggaattaatacaccttattttgggatattagtatcattaatacca tttgtcatagcgacttatttttataaaaaaacgaatggtttctttttactagcaccttta ttcgtaagtatggttgcaggtattgcttttttgaaattgacaggaattagttatgagaat tataaaatcggtggcgacattattaattt cttcctagaaccagctacaatatgctttgcg attcctttatatcgcaagcgcgaagtattaaaaaaatattggttacaaatatttggtggt atagctgttggtacaattattgccttgttattaatttatcttgttgcaataacattccaa tttggcaatcaaattatagcatctatgctacctcaagctgcaacgacagcaattgcatta cctgtatctgacggtatcggtggtgtcaaagaattaacctcactcgcagttattttaaat gcagttgtcatttctgctttaggtgctaaaatagttaaattatttaaaatatctaaccct attgccagaggacttgcactagggacaagtggacacactttaggtgtcgcggcagctaaa gaattgggtgagactgaagaatcaatgggaagtattgcagttgtcatcgttggcgttatt gttgtagcagtagttcctatacttgctccaatcttatta 516. atgaaaagaacagataaatatagagattcatacaaatatgatgaccaatatcaaaatcat cgtaaacgttcagaagaagatatgtatcgacaacatcaagagtcccaacagagagcaaat tcaaatcgtgcaacacaaagtgaaaatgatagagagtatgaaaatcatcctgaacgttat tacaatggaagagactatcgacgtgagcagcaattggaagaagaaaatgaaaaatcaagc aaaactaaaaaatggctgattgcaatcatagttattttactcattattgtagctatcttt atcacgcgtgcaattatcaatcataataatgataaagtaagtaatgaccctaacgtttca caaaactataaaaaggaagttgaaaatcaaaacgacgacattaatcgacaagttgattca gccaaaagcgatataaaaaataaaaaggacacccaatcccaaattgataaactacaaaat caaattga tcaattaaaacaaaatgaagaaactaatgcggattctaaattcacaaaattt tatcaaaaccaaatcgacaaactgaaaaatgcaaataacgctcaacttaataacgaaaat caaagtaaagttaacaacatgcttgaagacatcaatacaaaatttgatagtattaaagct aaactagaaaatatcttgaatggatcaaattcaggaaac 517. atgaacatgaaaaagggtgtttctcagcttacgttacagacattgagtttggtcgcaggc tttatggcatggagtatcatttctccattaatgccatttatttcacaagatgttgatatt tctccaggacaaatatctgtcattttagctattcctgttattttaggttctgtactacgt gtaccatttgggtacttaactaacattgtaggagcgaaatgggtgtttttctggagtttt attgtactattacttccaatttttcttttaggtcaagctcaatcacccggtatgctaatg ttatcaggattctttctaggaattggtggcgcaattttttcagtaggtgttacttcagta cctaaatacttttcaaaagacaaagttggtttagcaaatggtatatatggtgtaggtaat attggtactgcagtttcatcattttgtgccccagtgttagcaggtgcaattggctggcaa aatacagttcgtagttatttaattattctaagtatatttgcaattttaatgtttttttta ggagataaaaatgagccgaaagtgaagattcctttgatggctcaagtcaaagacctatct aagaattataagttgtattatttaagtttgtggtattttattacttttggagcttttgtg gcttttgggatttttttaccgaactttctagttgatcattttagtattgataaagtggat gcaggtattcgttcaggtatatttatagcactagcgacgttcttaaga ccggttggtggt gttataggtgataaatttaatgcagtacaagcgcttatcatcgacttcgtgataatgatt attggtgcgcttatattaagcttatctagtcatattgttctgtttacgataggctgttta gcaattagtatctgtgcaggtataggtaatggtttaatatttaaattagcaccttcatac ttttctaaagaagcaggttcagcgaatggtattgtatccatgatgggaggactaggcggt ttcttcccaccactggtgattacttttgtaacgagtatcactggttcaagtcatctcgct ttcttcttcttggctatatttggtgtaattgctcttattacaatgattcatttaaataaa aaagagaaagctattcgtata 518. atgaaaaataaaaaaggattaggcataggtcttatcacaattatgattatcgtttgtatt gtactagtaatcatgatgttcgtgggtggtaagaaagaatcatactacggtattatgaaa gatagcacgactattgataaaatgataaatactaaaaatgaaaaaattgaaaaaaacgta gaattacctaaagatgctaatgtatcagttaaaaaagaagattttgtgatgctctttaaa gatgaaaaaactggaaaaattactaaagttaagaaagttaatcacgatgacgtacctcat ggtttaatgtcaaaaatccatgatatgggtaatatgaaacacggaatg 519. atggctatgtcattactcgtgagtcttgtggtttatatgatgacactcacatctgatata ttagaagatattctatcatttaaattagaagtgataatgcaatttccgtatatattaagc tctatttcactaatcattttgtttatacttttcattttaaaagatatggaaaaaatatgg tactggctcatttcaatagttatgattgctgtgataagtatgtctggacacg tgtggtca caacaagtgccattatggtcaattatcataagaacaattcatcttatagggctaacgtta tggttaggttcactcgtttatctcatttgttatgctattaaagtgaaaattaatcagttg acgagtgtaagacgtatgcttttaaaagttaatatcattgctgtgattatgctcgttttt acagggattttaatggctattgatgaaacgaatactttaacactttggaataatgtgagc gcttggtctatttatcttgtcataaaaatcgcaggaattattgctatgatgctattaggt ttctatcaaacgatgcgtgctttgagacaacgacaacaggtccatcgttttgcactgatg actgaattgttaattggtatgatattaattttgcaggtatca 520. atgaaaaactctagattttctgggttccaatgggctatgatggtctttgtatttttcgtt atcacaatggcattgtccgtgatactcagagattttcaagcgactatcggagtgaaacgt tttgtctttagtattaaagatttagctcctttcatagctgcaattgtgtgcatattagta tttaagcacagaaaagaacaattagcaggattgaaattttctatcagtttaaaagtgatt gagcgtctacttttagcactcattctaccacttatcattttaatgattggcttgtttagc tttaatacttatgctgatagtttcatcctattacaaacttcagatttatcagtatcatta ttaactatattaattggtcatattttaatggcttttgtagtggagtttggtttccgttct tacttacaaaatattcttgaaacaagaatgaacacattttttgcgagtattgtcgttggt cttatttattcagtatttacagctaacacgacatatggtgtagaatacgccggataccat ttcttatatacattcatgttttcaatga ttattggtgaattaattagagctactaatggt cgtacaatttatattgcaactgcttttcacgcatccatgacttttgctctcgtcttttta tttagtgaagaaacaggcgaccttttctcaatgaaagtcatcgcactttctacaacaatt gtgggtgtttcatttattattattagtctaatcattcgtgctattgtttataaaacgacg aaacaaagtttagacgaagttgatcctaataattatttatctcatattcaagatgaagaa ccaagtcaagaagacgcctcttcaacttcaaatcatgatgtatcatctaaagatgaaaca aagcaacaagatattgataatgacaaacatcaatcaaagaaacctaataagagtgacgat gcacttactacttctaattataaagaagacgcctcttcagttaataaagaaacggataca actcacaatgataacattaaagatcattcaacttataccgaagatagacactcatctgtt gtcaacgatgttaaagatgaaattcacgaagttgaagatcataaagccgacacagataaa tcacat 521. atggaaaataatgagttgcaaaggggattgaatgcacgtcagatgcagatgattgctctt ggtggaacaattggtgttggtctttttatgggagcaacaagcacaattaagtggacaggt ccatcagttattcttgcatatttaattgctggtatttttttatttttaatcatgagagcc atgggtgaaatgatatatattaatccaaccactggttcttttgcgacgtttgctagtgac tatattcatccagcagctggctacatgactgcttggagcaatgtatttcaatgggttgtc gtcggcatgagtgaagtgattgcagtaggagaatatatgaactactggttcccaagcctt cctaattggataccaggagtgatagcagttctctttttga tggctgctaacctagtttca gtaaaagcgtttggagagtttgaattttggtttgccttaattaaagttgtaactattgta ttaatgattattgcaggattaggattaattttatttggtataggcaatggagggaatcca atagggatttctaacttatggtcacatggtggatttatgccaaatggattcattggattt ttctttgctttatctattgtgattggatcataccaaggtgttgaattgattggcatctca gcaggtgaaaccaaaaatcctcaaacaaatattgtaaaggcagtcaacggagtgatatgg agaattttaattttctatattggtgcaatttttgtcattgtatcagtatatccttggaac caattaggtagtattggtagtccttttgttgcaacgtttgctaaagtgggcattacgttt gctgctggtttaataaactttgtagtcttaacagcagcattgtctggttgtaattcaggt atttttagtgcaagtcgaatgatttatactttggcaaaaaaaggacaaatgcctaaagta tttactaaagtaatgaaaaatggcgtacctttctacactgtatttgcagtatctatggga atattaattggtgctttattaaatgttatacttccattaattattgatggagctgatagt atctttgtatatgtatatagtgcctctattttaccgggaatgataccttggtttatgatt ttatttagtcatctaagatttagaaggttacatcctgaaaaggttcacaatcatcctttt aaaatgccgggaggggcaattgccaattatttaactatcatgtttttactcctagtatta gtcggtatgttacttaacaaagaaactgtagtatcggttgttattggtatcgtgttttta acagctgtgacactttattatcttattagatatcacaaaaaggaacgacaaata 522. gtga aaagacttaagaattttattctcggcttactcattgtggctatagttggcttccta ttatttatgtatatagatgatagtcgcattcaaagttatcaagactacttcttacaattt aattggttccaaccactattgattgggcttgcaggattacttatattaatcggacttata ttagtacttagtatttttaaacctacgcatcgcaaacctggactttataaaaactttgat gatggacatatttacgtatcacgtaaagctgttgaaaaaacaatttacgatacaatcgct aaatatgatcaagttagacaaccaaatgttgtaagtaagctttataacaaaaagaataaa tcatttattgacatcaaagcagatttcttcgtaccaaaccatgttcaagttaagagttta acagagagtatccgtgctgatatcaaaagtaatgttgaacactttactgaaattcctgtt agaaaattagaagttaacgtacgtgatcagaaaacatctggtccacgtgtattg 523. ttgcaagattttgataacttaattcctggctggtttaaaacatttgttcaagtcgggaat gacttaatttggtctcaatatcttattggattattattaacagcaggttttttctttaca attagttctaaatttattcaactcagaatgttaccagagatgtttagagcattaactgaa aagccagaaactttaagtagtggtgagaagggtatttcaccatttcaagcttttgcgatt agtgctgggtcaagagtaggaactggaaatattgccggtgttgcaactgctattgttctt ggtggccccggtgcagtcttctggatgtggattattgcttttattggtgcagctagtgca tttatggaagcaacgcttgctcaagtttataaggtacatgacaaagaaggtggattccgt ggcggaccagcctattacataacaaaagg gctaaaccaaaaatggcttggaattgtattt gctgttttaattacagttacatttgcttttgtatttaatactgttcaagcgaatacaatt gctgaatcattaaatacacaatacaatattagcccggtaattactggaatagtacttgca gttattacaggtattatcatctttggtggtgttcgtagcatagctacactatcttcactt attgtgcctattatggctattgtttatataggtatggttttaatcattttattactcaat atagatcaaattgtacctatgattggcactattattaaaagtgcattcggagttcagcag gttactggtggtgctgtaggagctgctattcttcaaggtattaaacgtggtttattctca aacgaagctggtatgggatctgcacctaatgctgctgctacatctgctgtgccccatccc gttaaacaaggtttaattcaatcattaggtgtattctttgacactatgcttgtttgtaca gctacagcaattatgattttattatattctggtttgcaatttggtgatagcgcgcctcaa ggtgtagcagttacgcaatcagcgttgaacgaacatttaggttcagcaggaggtattttc ttaactgtagcagttaccttatttgcattttcatctgttgtaggtaactattactatgga caatccaatattgaatttttatctaacaataagatgatattatttatttttagatgtttt gtagtacttttagtatttgtaggtgctgttgctaaaacagaaacagtttggagtactgcc gatttatttatgggtcttatggcaatagtaaatatcatatcaattataggtttgtcgaat attgcgtttgcagtgatgaaagattatcaaagacagcgtaaagaaggtaagagacctgtg tttaaacccgaaaacttagaaataaatttatttggcattgagacttggggaca acatgca aaaatgccaaaaaaa 524. ttgaaaaaagaaattttagagtggattgttgccatagccgttgccattgcacttattgcc ataatcactaaatttgtcggaaaatcatattctattaaaggtgattcaatggatcctaca ttaaaagatggggagcgtgtagtggtaaatattattggctataaattaggtggcgttgaa aaaggaaatgtcattgtatttcatgctaataaaaaagatgattatgttaaaagagttatt ggaactccaggagatagtgttgaatataaaaatgatacactctatgttaatggtaaaaag caatcagaaccatacttgaactataatgaaaaacgtaagcaaactgagtatatcacaggt agtttcaaaacaaaaaatttaccaaatgctaatcctcaatctaatgttattcctaaaggt aaatatttagttttgggggataaccgtgaggtaagtaaagatagtcgttcattcggttta attgacaaagaccaaattgttggaaaggtatcgctcagatattggcctttcagtgaattt aaatctaactttaatccaaataacactaaaaat 525. atgttcaataaggtttggtttagaacaggaatattttttattatgctgttcatactcatc aaactatttatggaagtgcatgaagtatttgctccaatagctactatcattggttcagtc ttccttccatttttaattagtggatttctcttttacatatgtttaccttttcaaaacata ttagaaaagtggggctttccacgttgggctagtataacaacaatattcataggattaata gctatcatcgctattgtggtatcatttatagcacctatcattatttccaatattaataac ttaattaaacaaacaccatcattacaaaaagaagccgaacaattaattaatttctcgtta agacaaatggataaatt accagatgatgtcacacatcgtattaataaagcggttaaatcc atgggagatggcgcaacgtctattttatctaattcagtgtcatatattacgtctttcatc tcaactgtatttttattaataatggtgcctttcttcctgatatatatgctaaaagatcat gaaaaatttatcccagcaatcggtaaatttttcaaaggagaacgtaaagtttttgttgta gatttattaaaagacttaaacttcactttaaaatcatatattcaaggtcaagtgacagtt agtatcatcttaggtattattttatatataggttatacgattataggattaccatataca cctttattagtattattcgccggcgtagctaacttaataccatttttaggtccatggtta tcttttgcaccggcagcgatactaggtattattgatggcccttcaacttttatttgggta tgtgtcgtaacattaatcgcacaacaacttgaaggtaacgtgataactcctaacgtaatg ggtaaatcattaagcattcatccattaactattattgttgtcatacttgcagctggagat ttgggtggtttcacactcattcttgttgcagttccattatacgctgtaatcaaaacatta gtgagcaacatttttaaatatcgtcaacgtattgtcgataaagcaaatagtaatgttaaa gat 526. atgaatacaatcgtaaaacatacagtaggttttattgcttctatcgtactaacgctttta gcagtttttgtaactctatacactaatatgacattccatgctaaggtaactatcatcttt ggttttgctttcattcaagctgcccttcaattattaatgttcatgcatttaactgaaggt aaagatggacgtttacaatcgttcaaagttatctttgcaattatcattactttagtaact gttatcggaacatactgggtaatgcaaggtgg acactcttctcactta 527. atgtcttttcttaggaaacacaccgaaattatatttagttatatcatcggtatcgtttca ctttttacaggtctcattatttttattaacttacctttaatcaaacaatttaaaggtgac aaaaaggttgatacgcatgtgcataacgtatgggaattcctaaatgccttttttgccgag attataaaagtgatgagtaaatttattggtggctttccaattacaagtgccatagtaatc atcgtatttggtattctagtgatgctgttaggtcacactttatttagaactattaaatac gattatgacatttcaattttctttttagttattggcattatgtactttatcattacatta ttgctaatgacacaagtgtatggcttttttgctatcgtctttattattccttttacagtt catattggttacatagtttataaagatgagttgaaccaagacaatcgaaagaaccattat atgtggattattgtaacttatggaatgagttatcttattacccaaatttcgctatatgga cgtattgacgcaaatgaaattgaatcaattgatattttaagtgtaaatacattcttcatt attatgtggttattaggtcagatggctatatggaatttcttattcctaagacgttcatta ccactcactaaagaagaattaggcgaagaggaacctgaactttcaagaactaataaaggc aatgtatctaatcaaactaaagttcacttaaaacaactacaaaataagacaaccgagtat gcacgtaagactagaagaagtgttgatttagataaaattagagccaaaagggacaaattt aagcaaaaaattaacagcatagtagatatacaagaggacgatattccaaattggatgaaa aaacctaaatgggttaaacctatgtatgttcaattgttttgtggtgtaattattctgttt tt tgcttttctagaatttaataatagaaacgcattattcttaactggtgaatgggagtta tcacaaacgcaatatgtagttgagtgggtaacattattattgctacttttcattattatt atttatattgcaactacattaacttattatttaagggataaatattattatttacaactc tttatgggcagtattttattctttaaatttcttacagaatttatcaatattatggtacat ggattattattatcaattttcattacgccaatcttattattaatgcttattgcaatgatt gttgcttattctttacagttgagagaaaaa 528. atgttaggagagcaatatacacaaattaagcgtccagcaaatcggctaactgaaaaaata ttaggttggtttagttgggtattcttactcatattaactattgtttcaatgtttattgcg ctcgtatcttttagtaatgatacgtcaattgccaatttagaaaacacacttaataataat gaactcgtacaacaaattttagccaataatgatttaagtacaactcaatttgtgatttgg ttacaaaatggagtttgggcaattattgtttattttattgtttgtttgctcatctcgttt ttagcgttaatttctatgaatataagaattttgtctggtttactttttttaatagctgct atagtcacaattccgcttgtattgttgattgtaactctaatcattcctatcttattcttt atcattgcaatgatgatgtttgctagaagagatagaatagaaacagtgccatcttattat aatgaatatgatcaaccatactatgatgagagaggtttttatgaaccagagtcaagaaat gaacatggatataatgatgatgtgtatgaacctatgcatactaaaaaggaagatagaaat acaagacgtcaattcaatagaaatgctcagcaacaagattcctataatggt ataactgat aatcaacccgatgaagatacatcttccgatcaactttattcagacgaatatgtagataat gaagataaatattctcaatttccaaaaagagcagttgaaagtgaatatgcatctcaacaa actgaagatgaaccaacagtcatgtcaagacaagctaagtacaataaaaaatctaaaaat acggattttgaagatgcgcaacaggaacatatggaaggtaatcaatttgatgacgtagga gttgttgaaccacaaattgatcctaaagaactaaaagcgcaaagaaaaagagaaaaagca gaaatacgtgctaagaaaaaagaaaagagaaaagcatataataaacgtatgaaagaacga agaaaaaaccagccaagtgctgttaaccaacgacgtatgaattatgaagaacgtcgacaa atgattaataatgaacaagaagatacagataataacttaaatcaacaggaagattcaaaa aaagaaaat 529. atggaagagaataaaaatcaacctaataatgagaatatgtcgaataaagacgataataca atccatttgaatgatagtcaaagtaatgaagacttagagctttttagacggaataaaaac gctcgccaacgcagaagacgtcgcatagataaccaaagtaaagaaaaagatgctacgtct acacaatcacagttagaaactaaaccaatggataaatttattgataatcacaagtcgcat aatcaagataaagaaataaaaagtgatttaattgaggataatgttaatgatgaagatgac aatcaaaaatataataatgataaattaaatgatcgtagtgttcaacaaacaagcgaaacg cgtcaaagtaatgaagacgaagaggaatttctaactgatcatcagagcgaaaaacaaact aaagactctcgtcattctaaaaaacataaattactaagtaaatttacttctaaaaaagaa aaggaaacatttacatcgttcaatagtaatgagaaggtaactcaaattaaaccgcttagt ttagaagaaaaaagagccataagacgtaaaaagcaaaaaagaatccaatatacaattatc acactactcattcttatcattgttctcattttactctatatgtttacaccactaagtaaa atatcaaatgtaaatattaaaggtaataacaacgtaagtacgagtaaaataaagaaagaa cttaacgttacttcacgttcacgaatgtatacttttagtaaaaataaagcgattaggaac ttaaaacagaatcctttaatcaaagaagttgatattcataaacaattaccaaacacgtta actgttaacgtgactgagtaccaaattgttggtttagaaaaaaataaagataaatatgtg ccaattatagaagatggtaaagaattaacagaatacaaagatgaagtttcacatgatgga cctatcattgatgggttcaaaggagacaaaaaaacacgaattataaaagctttatctgaa atgtcacctaaagtgagaaacttaatagcagaggtgagttacgcaccaactaaaaataaa caaagtcgcataaagatttttaccaaagataatatgcaagtcattggtgacattacaacg attgcagacaaaatgcaatattatcctcaaatgtcacaatcattaagcagagatgattct ggcgaacttaagacaaatgggtatattgatttatcggttggagcgtcatttattccttat caaggttcatcaactgttcaatcgggtactgaacaaaatgtaaccaagtcaacacaagaa gaaaatgatgcaaaagaagaacttcaaaatgtgttgaataaaattaataaacaatctaaa gaaaataat 530. atgaagtgtttgttcaaaatgctatcaatcataataataatgttaagtactttcacctta ttcatcag tccgagtacatatgcaaatgaagatgaaaattggactaaaataaaaaatcga ggagaactaagagttggattgtcagctgattatgcacctttagaatttgaaaagacgata catggtaaaactgaatatgcgggtgtagatatagaattagctaaaaagattgcgaaagat aatcatctaaagctaaaaattgtaaacatgcaatttgatagcttattaggtgcacttaag accggtaaaatcgatattattatctccggtatgacaacaactcccgaacgaaaaaaagaa gtggattttacaaaaccttacatgattacaaataatgtgatgatgattaaaaaagatgat gcaaaacgttatcaaaacatcaaagattttgaaggcaaaaaaattgctgcgcaaaaaggg acagatcaagaaaaaattgcacaaactgagattgaagatagtaaaatttcttcactcaat agattacctgaagctatattatctttaaaaagtggaaaagtagcaggtgtagttgttgaa aaaccagtaggtgaggcatatttaaaacaaaattcagaactaacattttcaaagattaaa tttaatgaagaaaagaaacaaacatgtatagctgttcctaagaactctcctgtactttta gataagctaaatcaaacgattgataatgtaaaagaaaaaaatttaattgatcaatacatg acaaaagcagccgaagatatgcaagatgatggaaattttatttctaaatatggcagtttt ttcattaaaggaattaaaaatactattttgatttcattagtaggtgtggtattggggtct attttaggctcttttatagctttattaaaaataagtaaaattagaccattacaatggata gcaagtatatacatagaatttttaagaggtactcctatgcttgtgcaagtgtttattgta ttttttgggactactgcagctttggggttaga tatttcagctttaatttgtggtactatt gcgcttgttataaattcttcagcctacattgccgagattattagagctggtattaatgct gtagataaaggacaaactgaagctgctagaagtttaggattgaattatagacagactatg caatcagtagttatgccacaggcaattaagaaaattttacctgcattaggtaatgaattt gtaaccttgattaaagaatcgtctatagtttccacaattggagtgagtgaaatcatgttt aatgcacaagttgtacaagggatatcttttgatcctttcacaccattgttagttgcagca ttactatatttcttacttacatttgcacttacacgtgttatgaattttattgaagggaga atgagtgccagtgat 531. atgcaacaagaaacgacatcatggtacaaacaagaatggtttatagttttatcactttta ttcatttttccactaggtttatttctcatgtggaaatttagcaagtggccatctattgca agaacaatcattactgttgcaatttcagttatcgtattagcaagcattacctattatggt aatctacaaatgattgtaccagcaacatcaaattcaaataacgaaactaaagaaactaca gagaataatgtaaatgataaagacgagcgaaatcataaaactgcagtagaagaaacaaaa actaattatgactccaccaaagaaaatactaaagaacctggaaaagaaaatgaatctgca acacgattggagaactctgcgcttgaaaaggcaaagtcatattatgatgattttcacatg tctaaactaggaatttatgatattttaacatctgaatatggagaaaaatttgataaagaa gatgcacaatatgctatagatcatctagaggctgattatgaaaagaatgcacttgagaaa gcaaaatcatatgccaaagatatgcatatgtctaa tgactcaatttacgatcttttggtg tctaactacggtgaaaaatttacagaatcagaagcaaaatatgctattgagcatttggat aat 532. atgagtcataagatattagtatcagacccaatttctgaggatggtttacaaagtatttta aaacatccagaatttgacgtagatatacaaacagatttatctgaaaatgatttagtaaat atgatttcaacttatgatgctcttatcgtacgaagtcaaacccaagtaacagagcgaatt attaatgctgcaacaaatttgaaggtcattgcaagagctggtgtaggtgtggataatatt aatatagaagcagcgactttaaaaggtattttagtaattaatgctcctgatggtaataca atttctgctacagaacattcagtagctatgttgcttgcaatggcacgaaatattcctcaa gcacaccaatctttacgtaacaaagaatggaatcgtaaagcatttagaggggttgaactt tatggcaaaaccttaggtgttatcggtgctggtaggattggtttgggcgtcgctaaacgt gcgcagagtttcggtatgaaaattttagcgttcgatccttatttaacagaagataaagcg aagtcattagatattcaaattgcaactgttgatgaaattgccgaaaaatccgactttgta acagttcacacaccattaacacctaaaactcgaggaattgttggttcatctttctttaac aaagctaaacaaaacttacaaatcataaatgttgccagagggggtattatagatgaaact gcacttattgaagcattagataataacttaatagatcgtgcagctattgacgtatttgaa catgaacctcctactgattcccctctcattcaacatgataaaattattgtcacaccacat cttggcgcctctactgtagaagcgcaagagaaggttgcagtctctgtatc tgaagaaata attgaaattctaactaaagggaatgttgagcatgctgtgaatgctccaaaaatggattta agcaaagttgataaaacaactcaaagctttataggtttaagtacaactattggtgagttt gctattcagcttctcgatggtgctccgagtgaaattaaagttaaatatgctggtgactta gcgcaaaatgacactagtttaattacaagaacaattataacgaacatcttgaaagaagat ttaggtaatgaagtcaatattattaatgcattagcaatacttaaccaacaaggtgtcacg tataatatagaaaaacaaaagaaacattctggctttagtagttacattgagctagaacta gttaatgatcaagataaaatcaaaattggcgcaacggtattcgcaggttttggcccaaga atagtacgtattaatgattactcacttgattttaaacctaaccaatatcaattagtaaca tgtcataaagataaacctggtatagtaggacaaacaggcaacctattgggaagtcacgga attaatattgcgtcaatgactttaggacgtaacgatgctggtggagatgctttaatgatt ctttctattgatcaacaagcaagtgaggaagttataaaaattttaaatgaaacaagcgga ttcaacaaaattattagcactaagttaacaatt 533. ttgaagcggaattttattaataatttaatcatattattaattgctattatgttaagtctg ttattaaaaatgttacatgtgattttgccatttatgtttggaccaatattagcggcgtta ttatgtgtaaaagtattaaaattaaaaatacgatggccattttggttgagtcaaattggt ttaatactacttggagttcaaattggctctaccttcacacaacaagtgattaaagacata agtaaaaattggctaactatcgtttttgtcactat cctactaattttattagctttgata attgcattcttttttaagaaaattgcacaagtaaatttagaaactgcaattttaagtgtt ataccaggtgcgctaagccaaatgttagtgatggcagaagaaaataagaaagcaaatata ttagttgtgagtttaacacagacatcacgtgtaatatttgttgttattttagtaccactt atttcgtatttttttcaggataaccatcatgaaatgaatcatactacaatggaagtaccc acactttctcagactttaaatatatggcaaataatcatcttattctcaatggtgggaatc atctatataggaatgtcaaaaattaacttccccactaaacaattattagcacctataata gttttaattatatggaatatgacaacacatttaacattttcactagatcattggttgtta gccacagcgcaacttatttatatgatacgtattggattacagattgccaacttaatgagt gatttaaagggaagaattgcaatagcaatagcctttcaaaatataatgctcatagtcaca acgtttataatgataataggaatacatttgattactaatgaatccatcaatgaattgttt ttaggagcagcaccaggaggtatgagtcaaatagttttagtggctatggctactggagct gatgtagcgatgatttcaagctatcacatttttagaatattttttatattatttgtcatt gcgccactaattggttattttattaatgttaaattaaataataaa 534. gtgaagaaaacgagtagaataattgcattcatactcctcatagctctactattcacagga atgggtatgacgtataagaatgtagttaaaaatgttaatttaggtctagatttgcaaggt ggttttgaagtcctcttccaagtagatcctttaaataaaggagataaaattgataaaaaa gcacttca agctacatctcaaacattagaaaatcgtgtaaatgttctaggtgtatcagaa ccgaaaatacaaatcgaagatccaaatcgaattcgtgtacaattagcaggtatcaaggat caagcacaagcgcgtaaattattatcgacacaagctaatttaacaattagagatgctgaa gatcatgttttaatgtctggttcagacattaaacaaggctctgctaaacaagaatttaaa caagaaactaatcaaccaacagttacatttaaagtaaaaagtaaagataaatttaagaaa gtaactgaaaagatttctaaaaaacgtgacaatgtcatggtagtttggttagatttcgaa aaaggcgatagttacaagaaagaagctaaaaagcaacaagaaggtaaaaagcctaaattt atatctgcagcgagtgtagaccaacctattaattctagtagtgttgaaatttcaggtggc ttcaatgggaaaaaaggtgttgaagaagcgaaacaaatagctgagttattaaatgccggc tcattaccagttgatttaaaagaaatttactctaactctgttggtgcacaatttggtcaa gatgctcttgataagaccatgtttgcatcaattgtaggtatagcattaatttatttattt atgcttggtttctatcgtttgcctggtttagttgcaatcattgccttaaccacttatatt tatttaactttagtcgcattcaatttcatatcaggtgtattaactctacctggattggcg gcattagttttaggtgtaggtatggctgtcgatgccaatatcataatgtatgaacgtatt aaagatgaactaagaattggacgcacgcttaaacaagcgtattcaaaagcaaataaaagt tcattcttaactatatttgattccaacttaacaactgtcatcgctgcagctgtgcttttc ttctttggagaaagttcagtcaaaggcttcgc aaccatgttactcttaggtattttaatg atatttgtaaccgcagtattcttatcaagagggttgttatcattactggtatcttcaaac ttctttaaaaaacaatactggttatttggtgttaagaagaaggatagacatgatattaat gaaggtaaagatgtacatgatttaaaaacatcatatgaaaggttaaactttgttaaatta gctaagccacttatttcacttagtattttaattgtaattattggtttgattatcatttca atatttaaattaaacttaggtattgatttctcatccggaacaagagcagatattcaatct aaaaatgctataacacaagcacaggttgagaaaactgtaaaatcagttggattggaacca gatcaaatacagattaatggtagtggaaataaaaatgccacagttcagtttaaaaaagat ttatcacgtgaggaagacaataaattaagtgctaaggtgaaatctgaatttggagataat ccacaaattaataccgtttcacctctcataggccaagagctagctaaaaatgctgtaact gcattaatacttgcttctataggcattattatctatgtttcactaagatttgaatggcgt atgggtctatcttctgtacttgcattattacatgacgtatttatcatcattgcaatcttt agtttgtttagattagaagtagatttaacatttattgcagcagtattaactatcgttggt tattcaatcaatgatacaatcgtaactttcgaccgtgttcgagaaaatctgcataaagtt aaagtaattacgcatactgatcaaattgatgatatagtcaaccgctctattagacaaact atgacacgttctattaatacagtgttgactgtagttgtagttgtagttgcaatattaata ttaggtgcaccaacaatatttaatttctctttagcattactaattggattattatc tggt gtattctcgtcaattttcattgctgtaccattatggggcatgcttaagaaacgacagttt aaaaagacaaaaaataataaattagtagtacacaaagagaagaaatctaacgatgaaaaa atcttagtt 535. atgggggaaaatacaaaacaagatttcaatcaaaaaggacaaaattttaaattcacaaaa aaacatagacgattattatatggttcagtttttttaatggctacatcagctattggtcca gcatttctgactcaaactgcagtgtttactgcacaattttatgctagttttgcatttgca atattaatttctattattatagatataggcgctcaaataaatatttggagaatattagtg gtaactggattacgtggacaagaaatatctaataaagtattacctggacttggtactatt atctccatactaattgcatttggtggtctcgcatttaacataggtaatattgctggtgca ggtttaggtttaaatgcaatgtttggtcttgatgtaaaatggggtgctgcaataacagct atttttgcgatacttatctttgttagtagaagtggtcagaaaataatggatgttattagt atgattctaggtatcgtaatgattttagtagtcgcttatgtcatggttgtttcaaatccc ccttatggagatgcattagtacatacatttgcacctgaacatcctttcaaacttatatta cctataattacattagttggtggtacagtagggggttatattacttttgcaggtgcacat agaattctagattctggtataaaaggtaagtcataccttcctttcgtaaatcgatctgct gtagcaggtattttaacaactggtgtcatgcgcaccttattgtttttagctgtactaggt gttgttgtaactggcgttacgcttagttcagaaaatccaccagcatcagttttccaacat gcat taggtcctataggtaaaaatatttttggcgtagtaatatttgcagcagcaatgtcc tcagtaattggttctgcatatacaagcgcaacatttttaaaaacactacacaaatcgtta ctcaataaaaataatcttatcgttattacatttattgtaatttcaacttttgttttctta tttattggtaaaccggtgagtttacttataatagctggtgcgattaatggttggattcta ccaatcacattaggtgcaattctcattgcaagtaggaaaaaatctatcgttggtaattac caacacccaacatggatgcttgtttttggtattatagccgtaattgtcacaataatgact ggtatcttttcattacaagatttagcaagtctttggaaaggt 536. gtgtctaataataattttaaagatgatttcgaaaagaatcgtcaatctattaatccagac gaacatcaaacagaattaaaagaagatgataaaacaaatgaaaataaaaaagaagctgac tctcaaaacagtttatctaataactcaaatcaacaatttcctccgagaaatgcccaacga cgaaaaagacgcagagagacagcaactaatcaaagcaaacaacaagacgacaaacatcaa aaaaatagtgacgctaaaactacagaaggttcattagatgaccgttatgacgaagcacag ttacagcaacaacatgataaatcgcaacaacaaaataaaactgaaaaacaatcacaagat aatagaatgaaagatggaaaagatgcagctattgtaaatggaacatctgagtcaccagaa cataaatcaaaatcaacacaaaatagacccggccctaaagctcaacaacaaaagcgtaaa tcagaaagtacgcaatcaaaaccgtcaacaaacaaagataaaaaagcagctacaggtgct ggaatagctggtgcagctggtgttgctggtgcagcagaaac atccaaacgtcatcataat aaaaaagataaacaagattctaaacactcaaaccatgagaatgacgaaaaatctgttaaa aatgatgaccaaaagcaatctaaaaaaggcaaaaaagcagcagtcggtgctggcgcagct gcaggagttggtgcggctggtgttgcgcatcataataatcaaaataaacatcataatgag gaaaaaaattctaatcaaaacaatcagtacaatgaccaatcagaaggtaagaaaaaaggt ggtttcatgaaaatcttgttaccacttatagcagccattcttattctaggtgcaatagca atattcggtggtatggctctaaataatcacaacgatagtaaaagtgatgaccaaaaaata gcgaatcaaagtaagaaagactcagataaaaaagatggtgcgcaatccgaagataacaaa gacaaaaaatctgatagtaacaaagacaaaaaatctgattctgataagaacgcagatgat gactctgataatagttcctcaaatcctaacgctacttcaactaataataacgataatgta gccaataataactcaaattatacaaaccaaaatcaacaagataatgcaaaccaaaatagc aataatcaacaggcaactcaaggtcaacaatcacatacagtatacggtcaagaaaactta tatcgtatcgccatacaatattatggagaaggaactcaagctaacgtagataaaattaaa cgtgcgaatggattaagcagtaataatattcataatggtcaaacattagttattcctcaa 537. atggctaaaggggaccaatatcaagctcatactgaaaaatatcatgataaaaagtctaaa aaaagttataaacctgtgtggattatcattagttttattattttaattacaatcttgtta ttacccacaccagcaggattacctgtaatggctaaagcagcactagctattttagctttc gctgtagttatgtgggttacagaagcagttacttatccagtttctgcaacattaatttta ggattaatgatacttttactaggtttaagtccagttcaagatttatccgaaaaacttgga aaccctaaaagtggcgacataatactaaaaggtagcgatattttaggaacgaataacgcg cttagtcacgcttttagtggtttttcaacctcagccgtagcacttgtagctgcagcatta tttttagcagtagctatgcaggaaaccaatttacataaacgacttgcattacttgtgcta tcaattgttggaaataaaactagaaatatagtcattggtgctattttagtatctattgtt ctagcattctttgtaccatcagctacagcacgtgctggtgcagttgtcccaatattactg ggaatgattgctgcatttaatgtgagtaaggatagtagacttgcttcattattaattatt actgctgtacaagcagtttcgatatggaatataggtattaaaacggctgcagcacaaaat attgtagccatcaattttattaaccaaaatttaggacatgatgtatcatggggagagtgg tttttatatgctgcgccgtggtcaatcattatgtctatagctctttattttataatgatt aagtttatgccacctgaacatgatgcaattgaaggtggaaaagagttaattaaaaaggaa cttaataaattaggaccagtcagtcatagagaatggcgactaattgtgatttcagtgctt ttattattcttctggtcgactgagaaagtattgcatccgattgattcagcttcgattaca ctagttgctctaggtattatactaatgccaaagattggtgttattacttggaaaggtgtt gaaaagaagattccttgggggacgattatagtatttggtgtaggaatctcacttggtaat gtattacttaaaacaggagccgc tcaatggttaagtgatcaaacatttggtttgatgggt cttaaacatttaccgatcatagcaactattgcgttaattaccttatttaatatattaata catttaggttttgcaagtgcaacgagcttagcctctgcgttaatacctgtgtttatttct ttgacttcaacgctaaatttaggtgatcatgctattggttttgtattaatacaacaattt gtgattagttttggtttcctactacctgtcagtgcaccacaaaatatgcttgcatatggt actgggacttttaccgtaaaggattttttaaagacaggtatacctttaacgatagtaggt tatattttagttatcgtatttagtttgacgtattggaaatggcttggtttagtg 538. atgttagatttcattaaccatttgcttagttatcaatttttaaatcgtgcattaatcaca tctattttagttgggattgtatgtggaacgatgggtagcattattgttttacgtggtctt tctttaatgggtgatgccatgagtcatgctgttttaccaggtgttgctttatctttctta tttaatattccaatgtttatcggggcacttgtaacgggaatgcttgcaagtttgtttatt ggttttattacttcaaacagtaaaacaaaaccagatgctgcaataggaataagtttcact gcattcctagcatctggcgtcataattattagtttaatcaatagtacaacagatttatat cacattttatttggcaatttattagcaattacacatcaatcattttggacaacaattgtc attactgtactggttattttacttattattatcttttatagacctttaatgatttcaaca tttgatgcaacttttagtcgtatgagcgggctgaacacaacattaattcactactttgtc atgttattactcgcacttgtaactgttgcgagcatacaaacagttgga attatccttgta gttgctttactaatcactccagcttctacagcttttttaatcagtaaacaactttatgcc atgatggtaattgcaagcataatcagcgtgataagttcgattatcggtctatattttagt tatatatataatattccaagtggagcaactattgtaatctgtacctttatgatttatatt gtaacgctatcaattactagaattaaaaataaacaaaaaaggagcgctttaacg 539. ttggcaaagctattatacaaactaggaaaatttatagctaagaacaaatggctaagtgtt ataggatggcttgttatactaggtgttattatcacgccattaatgataaactcaccgaag tttgacagtgacatcactatgaacggccttaagtcattagacacaaacgataaaatcagt aaagaatttcatcaggacagtgagaaagcctcgatgaaaatagtcttccattctaataag aatgatggactcaataataaagatacgaagaaagatattgaagatgctttagacaatatc agacaaaatgatgattatatccaaaatatctctaatccatatgacagtggacaagttaat gatgaaggcgatactgctatcgctaacgtaagttatgtagttccacaaactggattaaaa gattcttctaaacatatcatcgacaaagaattaaaagatgtaactgacaaccataatgtg caaattgaaaaaactcaaggtggcgctatgaattccgaacctggtggtacatcagaaatt gtcggtatcatcgtagcattcgtaatcttacttattacctttggttcacttatcgcagct ggtatgccaattattagtgcaatcatcggtttaggttcaagtgttggtatcatcgcatta ttaacatatatctttgatattccaaacttcactcttacactagctgtaatgataggttta gctgttggtatt gactactcactctttattctatttagatttaaagaacttaagaaaaaa ggtgtcgatactgtagaagctattgcaacagcagtgggtacagcaggcagtgctgtaata ttcgctggtcttacagttatgattgctgtttgtggtttatcacttgtaggaatcgacttc ttagcggttatgggattcgcttcagcgattagtgtgttatttgcagtattagcagcatta acactattacctgccctaatcagtatcttccataaaagtattaaaattaaagataaacca actaaaagtaaagaccctaaagatcattcttgggcaaaatttattgttggtaagccagtt atcgctgttattgtaagtttaattattttaattttagctgctataccagtcagtggcatg cgtttaggtattccagatgatagtttaaaaccaactgactcatcagaatacaaagcctat aaattaatctcagataattttggcgaaggttataacggacaaattgtcatgttagtaaat acaaaagatggtggaagtaaaagcactatcgaacgtgatttaaataatatgcgtagtgat ttagaagacattgataatgttgatacagtttcaaaagcacaactaactgacaacaacaat tacgcattattcacaatcattcctgaaaaaggaccgaactcacagtcaacagaaaatcta gtatatgatttacgtgattatcatagccaagcgcaagaaaaatatgactatggcactgaa atttcaggacaaagtgttattaacatcgatatgtcagaaaaactaaacaacgctattcca gtatttgcaggcgttattgttgtattagcattcttcttattaatgattgtgttccgttcg atcttagttccattaaaagcagtactaggctttatcctttcattaatggctacattaggt ttcacaacattagtcattcaacatggctttatgggt agcttatttggtattgaaaacaca ggaccattacttgcattccttccagtaatcacaattggattgttattcggacttgccatc gactacgagctcttcttaatgacacgtgtacatgaagaatacagtaagactggcgataat gatcattcaatccgtgtaggtatcaaagaaagtggacctgttatcgtagctgctgcactt attatgttcagtgtattcatcgcattcgtcttccaagatgacagtgcaattaagtcaatg ggtatcgcattaggtttcggtgtgttattcgacgcattcgtcgtacgtatgacattaatt ccagcattgacgaaactctttggtaaagcttcatggtaccttcctaaatggttaggtgca gtattgccaaacgttgacgttgaaggtaaagctttagaagaagataatcatcacgacaca tcttctgaaaaaggtcatgtcaacgataaaaatagtgaatactctagacaagacaaagat aactatgtttatcaaaatgacaaacgtaactacaatcgcaattataatgacgaagattat aaccgttctgtgcatttaaataatcatcatgaccagcatcatcgccaacatcaatatgat aatcaacgtgatgatatcgactatgaatcactttatactcaagatggcgaccatactcat catgatgaacgtaattataatgatcgacactatcaagacaattacgatagaaatgatgat tatcgtcacaacaatcatgatcatcaaaatgataaccatgattatcatgattcaaatttt gataaaacaacaaacttatacaaagaattaactgatagcaatattgatcaagatgtatta ttcaaagcattaatgttatacgctcgtgaaaacaacaaaggtgtttacgatagatataac cgatcatctcaacatcgtcatgatgacgaacttagagac 540. atgaataaaaaagta gaacatatcggtaaccaatatacgtcacaagaaaataagaaaaaa caacgacaaaaaatgaaaatgcgtgttgtacgtagacgtattgctttattcggaggtatt cttttagcgattatcctcattctacttgtattgcttgtcattcaaagacataataacgat caagatgcagttgaaaggaaagagaaagaaactgagtttcaaaaacaacaagatgaagaa attgctttaaaagagaaacttaataatttaaatgataaagactatatcgagaaaatagcg agagacgattattatttaagtaataaaggtgaagtcatttttagattacctgatgataaa aaatcctctcagtcaaagacttcaaacgaaaaaggcaat 541. atgaagatacgtttaacatttattatcttagcaatactatccaccatcggcttagtactt gttttagcaaaatatccaacaggcccacacacaatcaactataacgaaccttatacagta ctcatagccattacgacaatagttataatggctttaccagcactcatattaggtatattt aatcatcttgcatgtagaatcatatcggcgatattacaaataagtgcactgatgatgtgg gggtttttagtaatcattagcttaattatgggacaaattgtcattatgcttatggcttcc ttaacgatacttgcattacttgttagttctattgtcacactttcagtgcacccatctact tcagataaaataaat 542. atgaataagaaactattgtggagcatcattggtattgtaattattgtcgtattaatcatt gctgcttttatattaaaacaagttaatggttcaggtagtaaagatagtaatgcttacgat acatatacagtaagaaaagaaacacctattagtttagaaggcaaagcgtctccagaatct gtgaaaacttataacaataatcaatctgtgggta acttcttaagtgtttcagtacaagat ggtcaaacagttaaacaaggtgaacgtatcatcaattatgatacaaatgggaataaacgc caacaactattgaacaaagtgaatcaagcacaatctcaagttaatgatgattatcaaaaa gtaaatcaaagtcctaacaatcatcaattacaagttaaattgactcaagatcaaagtgct ttaaatgaagctcagcagtcattgtcacaatatgacagacaactcaatgacagcatgaat gcatcatttgatggtaaaattaacattaaaaatgattcagatgtaggcgaagggcaacct attttgcaattaatttcttcaaatcctcaaattaacgcaactattacagagtttgatatt aataaaattaaagaaggcgatgaagtaaatgtcactgtaaatagcacaggtaaaaaagga aaaggaaaaattcttaaaatagatgaacttcctacaagctatgatacaagtgacgatagt acagcatcatcggcacaagcaggggcacaaggtgatagtgaagaaggaactgaaatgacg acatctaatcctacaattaatcagccaacaggtggtaaaagtggcgaaacatcaaaatat aaagttatcattggtgatttagatatacccgtgagatcaggcttctctatggatgctaaa atccctcttaaaactaaaaagctaccaaataacgtgttaacaaaagataataacgtattt gtcgttgataaaaataataaagttcacaaacgtgaaattaaaattgaacgtaataatggt gaaatcattgtgaaaaaaggattgaaatctggcgataaagtccttaaaagtccaaaaggt aatttaaatgatggagaaaaagtagaggtgtcatca 543. atggctgaaactactaaaatatttgaatcacatttggtcaaacaggctctaaaagacagt gtattgaagctctatc ctgtttatatgattaaaaatccgattatgtttgttgtagaagtg ggcatgctgcttgccttaggattaaccatttatccggatttatttcaccaagaaagtgta tcacggctatatgtgttcagtatctttatcatattattactgacacttgtctttgcgaac ttctctgaagcattagctgaaggtcgcggtaaagcacaagccaacgctttacgccaaaca caaactgaaatgaaggcacgtcgtattaaacaagacggcagttatgaaatgattgacgct agtgacctgaaaaaaggacatatcgtacgtgtcgcgacaggtgaacaaatcccaaatgac ggtaaagttattaagggcctcgcaacagtggatgaatctgcgattacaggtgaatctgca cctgtaatcaaagaaagcggtggagatttcgataatgtaattggaggaacttctgtagct tcagactggttagaagttgagattacttcagaaccaggtcattcatttttagataaaatg attggtttggttgaaggggctacaagaaagaaaacacctaatgaaattgcgttatttact ttattgatgacattaacgattatcttcttggtcgttattttaacgatgtatccattggcg aaattcctgaatttcaatttatccattgcgatgctgattgctttggctgtgtgtttaatt ccaacaaccattgggggattattatcggctatagggattgcagggatggatcgtgtgaca cagtttaatatcttggctaaaagcggacgttctgtagagacttgtggtgatgtgaatgtc ttgattttagataaaacaggtaccattacctacggcaaccgtatggcagatgcgtttatt ccggtgaaatcatcaagctttgaacgtttagttaaagcggcctatgaaagttctatcgca gatgacacaccagagggacgtagtattgtgaaattagctt ataaacaacatatcgactta ccgcaagaggtcggagaatatattccgtttactgctgaaacacgtatgagcggtgtgaaa tttacgacacgtgaagtatataaaggtgcaccgaatagtatggttaagcgtgtgaaagaa gcagggggacatattccagttgatttagacgctcttgtcaaaggggtgtctaaaaaaggt ggcacaccgctggttgtgcttgaagataatgagattttaggtgttatttatttgaaagat gtcattaaagatggactcgtagaacgtttccgtgaattacgtgagatggggattgaaacg gtgatgtgtacaggagataacgaattgacagctgcgacaatagcgaaagaagcgggtgtg gatcgctttgtggcagagtgtaaacctgaagataaaatcaatgtgattagagaagaacaa gcgaaaggtcatattgttgcgatgacgggtgacggtacgaatgacgcgccagctttagca gaagctaatgtaggtttggcaatgaactcaggaaccatgagtgccaaagaagcggcgaat ttaattgatttagattctaatccaaccaaactgatggaagtcgttctaattgggaaacaa ttattaatgacacgtggctcactcactacatttagtattgcgaatgacattgcgaaatac tttgcgattttaccagccatgtttatggcggctatgcctgcgatgaatcatttgaatatt atgcatctgcattcacctgaatcagcagtattatctgcgttaatctttaatgcgttgatt attgtattattgattccgattgcgatgaaaggcgtgaaatttaaaggtgcctcaacgcaa accatattgatgaaaaatatgttagtttacggcttaggcggtatgatcgtgccatttatc ggcattaagctcattgatctcatcatccaactctttgtc 544. atgattgtgttacgtcgtc tatttcaagatagaggtgccatatttgctatagctattatt acaatctacgtagtgcttggagttttagctcctttaattacattctatgaaccgaatcac attgatacagcaaataaatttgctggtataagttggtctcactggttgggaacagaccat ttaggtcgagatgtattaacacggataatatacgccataagacctagtttgttatatgta tttgtcgcattgattatttccgttgtgataggagcgatacttgggtttatttcaggttat ttcccaggttatatcgatgcaataattatgcgtatatgcgatgtgatgttagcttttcca agctatgtggtcacattggcattgattacgttgtttggcatgggtgtagaaaatattatt attgcatttatattgactcgatgggcgtggttttgtcgcgtgattcgaaccagtgtaatg caatatattgaagctgatcatgtaaaatttgccaaagtaattggtatgaatgatttaaca atcattcgcaaacatattttgccactaacctttactgacatagcgattattgctagtagt tcgatgtgttcaatgatattacaaatgtcaggattctcattccttggattaggtgttaag gcacctacagccgaatgggggatgatgcttaatgaagcacgaaaagtaatgttcacacat cctggaatgatgatgacaacaggtgtggctatcgtcataattgtgatggcgtttaacttt ttatcagatgctttacaaatggcgattgatcctcgtatgtccgctaaagaaaaacgactg gctctgaagaaaggtgtgaaagcacgtgacactgct 545. atgaaaggtgccatgtcttggccttttttaagattatatattttaacattgatgtttttt agtgcgaatgccatactcaatgttttcatacctctaagaggacatgacttgggggcgacg a atactgtaattggaattgtaatgggagcttatatgctaacggcaatgctatgtcgcccc tgggctggtcaaattattgcacgtattggtccgattaaagtattgcgtattatattattg attaatgctatggcactggtattatatgggtttacaggacttgaaggttatttgattgca cgtatcatgcaaggtgtgtgtacggcattcttctcaatgtctttacaattgggtattata gatgctttacctgagaaatatcgttcagaaggtgtatctctctattcattattttcaacg attcccaatttattaggaccattaattgcagttgggatttggcacgtggaaaatatgtcc atatttgctattgttatgatttttattgcagtaacaacaaccttatttggttatagaact acttttgcaaatacacaaaaagaggtatcaccaaaagacgaagtcttgccttttaatgca atgactgtatatgtccaattttttaaaaataaagcactcttctgcagtggtatgattatg atcttgtcatctatcgtgtttggtgcgatgagtacttttataccattatatacggttagg gaaggtttcgcgaatgcaggtattttcctcacaattcaagccattacagtagtgatagct agattttatttacgtaagtatgtaccatctgatggtttatggcatcaccgttttatgatg attgtcttaacgttactgatggttgcttcagtcattgtagcttttggaccacatatagtg agtatatttgtatatataagtgcaatctttatcggaataacacaagcgctcgtttatcct acattgacaacgtatttaagttttgtcttaccaaagataggacgtaatatgttattagga ttgtttatagcatgtgcagatttagggatttcactaggaggtgtgctaatggggccaata tcagatacggtaggatttaaatgga tgtatattttatgcgctttattggttactattgca atgacactaagtaaaattagacaaagacaaagtgtttcaaaagcctca 546. gtgggaagtactgttaaatatcgtaagtttattctacctattgtcgttggtttaattatc tgggcattgacgcctattaaaccagatgccttaaatgatcaagcttggtttatgtttgct atttttgtgtcaaccatcattgcttgtattacccaacctatgactataggtgcagtatca atcattggttttacaatcatgattttggttggaattgttgatacaaaaactgccgttcaa ggcttcggtaatagtagtatttggcttattgcaatggcctttttcatttcaagaggattt gtaaaaacagggctaggtcgacgtattgctctgcaattcgttaaattatttggaaagaaa acgcttggtttggcttattcacttgttggtgttgatcttatcttagctcctgctacgcca agtaatacagcacgtgctggtggtattatgtttccaatcattaagtccttgtcagagtca tttggttcatcgccgagagatggttctgagagaaaaatgggtgcgtttttaatctttact gagttccaaggtaatttaattacttcagctatgtttttaacagctatggccggtaaccct atagcgcaaagtttagctgaaaaaacggcacacgttcaaattacatggatgaattggttt gttgctgctattatacccggattgatttctctcatcgttgtccctttcattatttataaa ttatacccaccaactgttaaagaaacgcctaacgctaaaaaatgggctactgaacaacta gaagaaatgggacatatgtctatagccgaaaaattgatggttggtatctttatcatagca ttggctttgtgggtattaggaagcttcattaatgttgatgccacgctcactgcatt tatt gctttagcattgttactattaacaggtgtattagcgtggtcagatattttaaatgaaaca ggcgcatggaatacactcgtttggttctcagttcttgtattaatggcagaacaattaaac aagttaggctttatcccatggttaagcaaactcattgctcaaggtttaaatggctttagt tggcctatcgttttagttttactcatcttgttttatttctactcacattatttattcgca agtgcaacagcacatgtcagcgccatgtacgccgcgttactcggtgttgcagtcgcttcg ggtgcaccgccattattcagtgcattaatgttagggttctttggtaacttactggcatca acaacacactatagtagtggaccagcgcccatattatacgcagctggctatgttacacaa aagcgctggtggactatgaatattgtacttggtatagtctattttattatttggattggt gtaggttcactatggatgaaactcataggtatgatg 547. atgaaagataataaaatgttgttcattatttttatgataggaacatttacagtaggaatg gctgaatatgtagtgacaggattacttacacaaatcgctgacgatatgaaggtttctatt tcgagtgcaggtttattaattagtgtttatgctattagtgttgcattgatagggccttta atgcgaatcataacattgaaagttcacgcccaccgtctgttaccgattttagtagcgatt tttataataagtaatttagtgggaatgttagcaccgaattttaatgtattgttattatca agactcatgtctgcggcaatgcatgcgccattcttcggtgtgtgtatgagtgttgctgcg acagtcgcacctcctgctaaaaaaacacaggccattgcacttgttcaggcaggtttaact attgctgtaatgttaggtgtaccattcggatcattttt aggtggctttgcaaattggaga gttgtttttggatttatgattgtgttggcaatcattactatgttaggaatgattaaattt gttccaaatgtttctttaagtgcagaagcaaatattagcaaagaattaacagtgtttaag aatccacacattttaattgtgattgcaattattgtgtttggttactctggtgtgtttact acttatacatttatggagccaatgatacgagatttttctccatttaaaattgtaggttta actgtttgtttatttatgtttggtctaggcggtgtgatagggaatttaattactggtaat gtaccggaagataaattaacaaaaaatttataccttacatttcttttactatttgtaaca atcatactatttgttactgttattcaaaattcaatattagcattaatcatttgcttctta ttcggttttggtacatttggtacaaccccgttacttaatagcaaaattatcttaagtgga aaagaagcaccacttcttgcaagtacgttagcagcttctattttcaatgttgctaatttt cttggtgcaataattggatctatattattatcaatagggttaccttacattcaaattact ttgatatctggtggaattatagtgttgggtatgcttcttaatcttgttaatcaactttat gaaaagaaacatatcacatttaatgaatattca 548. qvlkmlqnilllmllllmlkikvliylimtllnqfrdmvlklrfinnkslwaien 549. krlvmqqhlqfnlpkiillnaltkrflsllvtqlvmvfilvvsllkvpvqlq 550. lrlrqfqllctlvllmlvalflhaflrylmtk 551. rlrytsyiiklaatdafklltcptigili 552. ssvfairltitfsrfsnvgckkhikgaiimkkeiiewivaiivaivivtlvqkflfasyt vkgasnviyh 553 . rsvphivvltmriiasvllvivgfslsvsca 554. tanniisfiitltniyktklmgyffniielrnkfirrcwailfiaiihfisecflphipt ncyvsrfdfldsaknmsyktlnticrnsfrivhkliv 555. ffcrltqlnwlkylsvrmlymyfmifsimnhivstic 556. ifistcgcsttsawkaevlplrvrfpspapf 557. lknilrivfiagltvffsgpgqtysnaafideyiqtfgwsrtev 558. rnsnqmyqtftadivlifmiivlgglvvqvpmpilagimvmvsetiyclhl 559. nqrleetissphhssal 560. mkqflnitqrkfiewliilsifivsipnkwtlmisialsllllkrgalgvvqliilymlr sqiytpydtqemahyivsmkyiliyvigvfflfkyvkhwirnemilrfikstmilmllyi imslvvsndpiesilkllnffiplilivmyvslikkiknlinwinqfitlviaftflfiv iapksylideeslrsvfkdahsfavilamglvlymvtiikqqdydvfnllllnigmiely lsnsrhifisvilclmlllplshikkrikhpiigamilmaiaiinqpyiyhlfiklilkg knsqevfmpsdmnikaidyaltehpflgsgfgipmikasseiqyfnvatsniifgmiift giigltlctiymlhmvllvtfpmsitillflitifvnmdyiilfdsvglgilcyifwgiy lkegmyqynngqw 561. mtnqktvglvvapgvterlaenliqempkmlsthydhqqewifdlvtdpltgfaesvdei fgkvadyhdkrqwdyviaitdlpmfadkqvmaldinmengaaifsypafgwrpvkkrfkh aiyniiqelneaeqesrnydnnkqiensvkkqfplskidketiymketdsyhlrylsssr srgmfrlvsgmtfannpl nmmaslsnivaiafttgafglvfttmwqmaynfsmwrlfgis iiaiigmliwimmshdlwepvnksnhkhitwlynlttimtlifaiiiyyiilyllfliae ivllpsgflgqqvglkgpagidlylsipwfaasistvagaigagllndelikestygyrq rvryeeqrr 562. mkfcphcgnpikkeqsfcnkcgkhlktstqrksenqiehmreqqsyisreerqhhdstfy keqkhtgwlivlsiifvlliaallygayyaynhyisdeqshqttesqqsnesdqnrdqst gpsidvfsddfdqgymksastsgyrgvyngmtreevedkfgtsngsveslkwsyetygdl avayddnevvsvgvapnhisedqflsmynepddrnssqliydsnkdndfsvlanvkngdv tvienvnqi 563. mllfiieiiimilaillglrtagalgcgifaivaqlimifgfqlppgsapvtavliilsi giaggtlqatggidylvyiasrvierfpksiifiapmivfvfvfgigtanialslepiia ktaqkariqpkraltasvltanlallcspaasatayiisvlagyeismgkylsivlptal ismlmlstfctfvgrkehvrdeserlvqmpeveikndfslkvkigvisfllcvmgiltfg ifpnlmpqfnvngdvvkvemteivqffmylsatinlllikintsdilssnitqsamgalf avlgpgwlgatifnaphnlkilkndigsiisevpwlviilvsvvamivisqtatasimvp ivmslgippiyfvamvqtlnvnfvipaqptllfaveldetgrtrptsfmipgffvitvsv itgfviktilgy 564. mgsffnrmtrkenptiyqnkdghlkrtlrvrdflalgvgtivstsiftlpgvvaaehagp avalsfllaaivaglvaftyaemastmpfagsayswinvlfgelfgwvagwalla eyfia vafvasgfsanlrgliaplgislpkslsnpfgsnggvidiiaavviiltalllsrgmnea armenvlvilkvlaiilfvivgltainfsnyipfipehkvtetgdfggwqgiyagvsmif layigfdsiaansaeainpqktmprgilgslivaivlfvavalvlvgmfhysqyadnaep vgwalresghgiiaaivqaisvigmftaligmmlagsrllysfgrdgllpswlsqlnhkh lpnralviltiigvvigsmfpfaflaqlisagtlvafmfvslamyrlrkregkdlpkpef klplypilpaitfilvllvfwglsfeaklytliwfivgiiiyliygirhskkndeeayqv pre 565. mtkkkrlspsewllkqskrhkrkntlytaivllvalvllifavksiqvepvksdtrdkds iritylgnvtlnkhirqtnlndvfkgiqdtldhsdfstgslivndfsrnqkdninknien imflrkhnvksvnlinesmdniqatammrkidsqagynfltgngsnpinsktvqqdikgk kianvsftdiesnytnslknttsisldpaifyplikklkenndyvvvnvdwgipnernvt trqkeyahalanagadviighntviqkvenykrtpifyslgnttsdnflsknqkgmivqq dwkgshnqfhitpiqskdgkiskdnmnkmdhirfknnikdksidlksdqnggytfey 566. miehlgintpyfgilvslipfviatyfykktngffllaplfvsmvagiaflkltgisyen ykiggdiinfflepaticfaiplyrkrevlkkywlqifggiavgtiiallliylvaitfq fgnqiiasmlpqaattaialpvsdgiggvkeltslavilnavvisalgakivklfkisnp iarglalgtsghtlgvaaakelgeteesmgsiavvivgvivvavvpilapill 567. mkrtdkyrd sykyddqyqnhrkrseedmyrqhqesqqransnratqsendreyenhpery yngrdyrreqqleeenekssktkkwliaiivilliivaifitraiinhnndkvsndpnvs qnykkevenqnddinrqvdsaksdiknkkdtqsqidklqnqidqlkqneetnadskftkf yqnqidklknannaqlnnenqskvnnmledintkfdsikaklenilngsnsgn 568. mknkkglgiglitimiivcivlvimmfvggkkesyygimkdsttidkmintknekieknv elpkdanvsvkkedfvmlfkdektgkitkvkkvnhddvphglmskihdmgnmkhgm 569. mamsllvslvvymmtltsdiledilsfklevimqfpyilssisliilfilfilkdmekiw ywlisivmiavismsghvwsqqvplwsiiirtihligltlwlgslvylicyaikvkinql tsvrrmllkvniiavimlvftgilmaidetntltlwnnvsawsiylvikiagiiammllg fyqtmralrqrqqvhrfalmtelligmililqvs 570. mknsrfsgfqwammvfvffvitmalsvilrdfqatigvkrfvfsikdlapfiaaivcilv fkhrkeqlaglkfsislkvierlllalilpliilmiglfsfntyadsfillqtsdlsvsl ltilighilmafvvefgfrsylqniletrmntffasivvgliysvftanttygveyagyh flytfmfsmiigeliratngrtiyiatafhasmtfalvflfseetgdlfsmkvialstti vgvsfiiisliiraivykttkqsldevdpnnylshiqdeepsqedasstsnhdvsskdet kqqdidndkhqskkpnksddalttsnykedassvnketdtthndnikdhstytedrhssv vndvkdeihevedhkadtdksh 571. mennelqrglnarqmqmialggtigvg lfmgatstikwtgpsvilayliagiflflimra mgemiyinpttgsfatfasdyihpaagymtawsnvfqwvvvgmseviavgeymnywfpsl pnwipgviavlflmaanlvsvkafgefefwfalikvvtivlmiiaglglilfgignggnp igisnlwshggfmpngfigfffalsivigsyqgveligisagetknpqtnivkavngviw rilifyigaifvivsvypwnqlgsigspfvatfakvgitfaaglinfvvltaalsgcnsg ifsasrmiytlakkgqmpkvftkvmkngvpfytvfavsmgiligallnvilpliidgads ifvyvysasilpgmipwfmilfshlrfrrlhpekvhnhpfkmpggaianyltimflllvl vgmllnketvvsvvigivfltavtlyyliryhkkerqi 572. lqdfdnlipgwfktfvqvgndliwsqyligllltagffftisskfiqlrmlpemfralte kpetlssgekgispfqafaisagsrvgtgniagvataivlggpgavfwmwiiafigaasa fmeatlaqvykvhdkeggfrggpayyitkglnqkwlgivfavlitvtfafvfntvqanti aeslntqynispvitgivlavitgiiifggvrsiatlsslivpimaivyigmvliillln idqivpmigtiiksafgvqqvtggavgaailqgikrglfsneagmgsapnaaatsavphp vkqgliqslgvffdtmlvctataimillysglqfgdsapqgvavtqsalnehlgsaggif ltvavtlfafssvvgnyyygqsnieflsnnkmilfifrcfvvllvfvgavaktetvwsta dlfmglmaivniisiiglsniafavmkdyqrqrkegkrpvfkpenleinlfgietwgqha kmpkk 573. lkkeilewivaiavaialiaiitkfvgksysikgdsmdptlkdgervvvniigyklg gve kgnvivfhankkddyvkrvigtpgdsveykndtlyvngkkqsepylnynekrkqteyitg sfktknlpnanpqsnvipkgkylvlgdnrevskdsrsfglidkdqivgkvslrywpfsef ksnfnpnntkn 574. mfnkvwfrtgiffimlfiliklfmevhevfapiatiigsvflpflisgflfyiclpfqni lekwgfprwasittifigliaiiaivvsfiapiiisninnlikqtpslqkeaeqlinfsl rqmdklpddvthrinkavksmgdgatsilsnsvsyitsfistvfllimvpffliymlkdh ekfipaigkffkgerkvfvvdllkdlnftlksyiqgqvtvsiilgiilyigytiiglpyt pllvlfagvanlipflgpwlsfapaailgiidgpstfiwvcvvtliaqqlegnvitpnvm gkslsihpltiivvilaagdlggftlilvavplyaviktlvsnifkyrqrivdkansnvkd 575. mntivkhtvgfiasivltllavfvtlytnmtfhakvtiifgfafiqaalqllmfmhlteg kdgrlqsfkvifaiiitlvtvigtywvmqgghsshl 576. mlgeqytqikrpanrltekilgwfswvflliltivsmfialvsfsndtsianlentlnnn elvqqilanndlsttqfviwlqngvwaiivyfivcllisflalismnirilsgllfliaa ivtiplvllivtliipilffiiammmfarrdrietvpsyyneydqpyydergfyepesrn ehgynddvyepmhtkkedrntrrqfnrnaqqqdsyngitdnqpdedtssdqlysdeyvdn edkysqfpkraveseyasqqtedeptvmsrqakynkkskntdfedaqqehmegnqfddvg vvepqidpkelkaqrkrekaeirakkkekrkaynkrmkerrknqpsavnqrrmnyeerrq minneqedtdnnlnqq edskken 577. meenknqpnnenmsnkddntihlndsqsnedlelfrrnknarqrrrrridnqskekdats tqsqletkpmdkfidnhkshnqdkeiksdliednvndeddnqkynndklndrsvqqtset rqsnedeeefltdhqsekqtkdsrhskkhkllskftskkeketftsfnsnekvtqikpls leekrairrkkqkriqytiitlliliivlillymftplskisnvnikgnnnvstskikke lnvtsrsrmytfsknkairnlkqnplikevdihkqlpntltvnvteyqivgleknkdkyv piiedgkelteykdevshdgpiidgfkgdkktriikalsemspkvrnliaevsyaptknk qsrikiftkdnmqvigdittiadkmqyypqmsqslsrddsgelktngyidlsvgasfipy qgsstvqsgteqnvtkstqeendakeelqnvlnkinkqskenn 578. mkclfkmlsiiiimlstftlfispstyanedenwtkiknrgelrvglsadyaplefekti hgkteyagvdielakkiakdnhlklkivnmqfdsllgalktgkidiiisgmtttperkke vdftkpymitnnvmmikkddakryqnikdfegkkiaaqkgtdqekiaqteiedskissln rlpeailslksgkvagvvvekpvgeaylkqnseltfskikfneekkqtciavpknspvll dklnqtidnvkeknlidqymtkaaedmqddgnfiskygsffikgikntilislvgvvlgs ilgsfiallkiskirplqwiasiyieflrgtpmlvqvfivffgttaalgldisalicgti alvinssayiaeiiraginavdkgqteaarslglnyrqtmqsvvmpqaikkilpalgnef vtlikessivstigvseimfnaqvvqgisfdpftpllvaallyflltfaltrvmnfiegr msasd 579. mshkilvsdpis 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fnili hlgfasatslasalipvfisltstlnlgdhaigfvliqqfvisfgfllpvsapqnmlayg tgtftvkdflktgipltivgyilvivfsltywkwlglv 585. mldfinhllsyqflnralitsilvgivcgtmgsiivlrglslmgdamshavlpgvalsfl fnipmfigalvtgmlaslfigfitsnsktkpdaaigisftaflasgviiislinsttdly hilfgnllaithqsfwttivitvlvilliiifyrplmistfdatfsrmsglnttlihyfv mlllalvtvasiqtvgiilvvallitpastafliskqlyammviasiisvissiiglyfs yiynipsgativictfmiyivtlsitriknkqkrsalt 586. lakllyklgkfiaknkwlsvigwlvilgviitplminspkfdsditmnglksldtndkis kefhqdsekasmkivfhsnkndglnnkdtkkdiedaldnirqnddyiqnisnpydsgqvn degdtaianvsyvvpqtglkdsskhiidkelkdvtdnhnvqiektqggamnsepggtsei vgiivafvillitfgsliaagmpiisaiiglgssvgiialltyifdipnftltlavmigl avgidyslfilfrfkelkkkgvdtveaiatavgtagsavifagltvmiavcglslvgidf lavmgfasaisvlfavlaaltllpalisifhksikikdkptkskdpkdhswakfivgkpv iavivsliililaaipvsgmrlgipddslkptdsseykayklisdnfgegyngqivmlvn tkdggskstierdlnnmrsdledidnvdtvskaqltdnnnyalftiipekgpnsqstenl vydlrdyhsqaqekydygteisgqsvinidmseklnnaipvfagvivvlaffllmivfrs ilvplkavlgfilslmatlgfttlviqhgfmgslfgientgpllaflpviti 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MAVKVAINGFGRIGRLAFRRIQEVEGLEVVAVNDLTDDDMLAHLLKYDTMQGRFTGEVEV VDGGFRVNGKEVKSFSEPDASKLPWKDLNIDVVLECTGFYTDKDKAQAHIEAGAKKVLIS APATGDLKTIVFNTNHQELDGSETVVSGASCTTNSLAPVAKVLNDDFGLVEGLMTTIHAY TGDQNTQDAPHRKGDKRRARAAAENIIPNSTGAAKAIGKVIPEIDGKLDGGAQRVPVATG SLTELTVVLEKQDVTVEQVNEAMKNASNESFGYTEDEIVSSDVVGMTYGSLFDATQTRVM SVGDRQLVKVAAWYDNEMSYTAQLVRTLAYLAELSK 596. vkrlknfilgllivaivgfllfmyiddsriqsyqdyflqfnwfqplliglaglliligli lvlsifkpthrkpglyknfddghiyvsrkavektiydtiakydqvrqpnvvsklynkknk sfidikadffvpnhvqvksltesiradiksnvehfteipvrklevnvrdqktsgprvl 597. msflrkhteiifsyiigivslftgliifinlplikqfkgdkkvdthvhnvweflnaffae iikvmskfiggfpitsaiviivfgilvmllghtlfrtikydydisifflvigimyfiitl llmtqvygffaivfiipftvhigyivykdelnqdnrknhymwiivtygmsylitqislyg ridaneiesidilsvntffiimwllg qmaiwnflflrrslpltkeelgeeepelsrtnkg nvsnqtkvhlkqlqnktteyarktrrsvdldkirakrdkfkqkinsivdiqeddipnwmk kpkwvkpmyvqlfcgviilffaflefnnrnalfltgewelsqtqyvvewvtlllllfiii iyiattltyylrdkyyylqlfmgsilffkfltefinimvhglllsifitpilllmliami vayslqlrek 598. mqqettswykqewfivlsllfifplglflmwkfskwpsiartiitvaisvivlasityyg nlqmivpatsnsnnetkettennvndkdernhktaveetktnydstkentkepgkenesa trlensalekaksyyddfhmsklgiydiltseygekfdkedaqyaidhleadyeknalek aksyakdmhmsndsiydllvsnygekfteseakyaiehldn