Anti-metalloprotease antibody for diagnosis and treatment of cancers |
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| 申请号 | US15116487 | 申请日 | 2015-02-04 | 公开(公告)号 | US10023653B2 | 公开(公告)日 | 2018-07-17 |
| 申请人 | MONASH UNIVERSITY; MEMORIAL SLOAN-KETTERING CANCER CENTRE; LUDWIG INSTITUTE FOR CANCER RESEARCH LTD; Beate Lackmann; | 发明人 | Martin Lackmann; Peter W. Janes; Lakmali Atapattu Mudiyanselage; Andrew M. Scott; Dimitar B. Nikolov; Nayanendu Saha; | ||||
| 摘要 | Expression of proteolytically active, high molecular weight ADAM protease is relatively increased in tumor cells that also express the putative tumor stem cell marker CD133. An antibody or antibody fragment such as 8C7 monoclonal antibody may be used to selectively bind to proteolytically active, high molecular weight ADAM10 protease to thereby detect tumor cells and also as a therapeutic agent for treating cancers, tumors and other malignancies inclusive of leukemia, lymphoma, lung cancer, colon cancer, adenoma, neuroblastoma, brain tumor, renal tumor, prostate cancer, sarcoma and/or melanoma. | ||||||
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