USE OF UPR SIGNALING PATHWAY GENES IRE1 AND HXL1 FOR TREATMENT OF FUNGAL INFECTION AND MENINGITIS |
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| 申请号 | PCT/KR2011009862 | 申请日 | 2011-12-20 | 公开(公告)号 | WO2012087004A2 | 公开(公告)日 | 2012-06-28 |
| 申请人 | UNIV YONSEI IACF; UNIV CHUNG ANG IND; BAHN YONG SUN; JUNG KWANG WOO; KANG HYUN AH; CHEON SEON AH; | 发明人 | BAHN YONG SUN; JUNG KWANG WOO; KANG HYUN AH; CHEON SEON AH; | ||||
| 摘要 | The present invention relates to the use of the UPR signaling pathway genes IRE1 and HXL1 for treatment of fungal infection and meningitis. In the invention, it was newly found that disruption of Ire1 and Hxl1 (HAC1 and XBP1-Like gene 1) proteins, newly identified in Cryptococcus neoformans, genes encoding the proteins, provides an antifungal effect and a meningitis-treating effect. Based on this finding, a candidate which can show a synergistic effect when being co-administered with an existing antifungal agent or meningitis-treating agent can be screened and a novel pharmaceutical composition having an antifungal effect and a meningitis-treating effect can be provided. | ||||||
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