Mutant endonuclease V enzymes and applications thereof |
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| 申请号 | US15048624 | 申请日 | 2016-02-19 | 公开(公告)号 | US10100292B2 | 公开(公告)日 | 2018-10-16 |
| 申请人 | General Electric Company; | 发明人 | John Richard Nelson; Robert Scott Duthie; Gregory Andrew Grossman; Anuradha Sekher; | ||||
| 摘要 | Provided herein are mutant endonuclease V enzymes that are capable of nicking an inosine-containing DNA sequence. Nucleic acid assays and agents that employ such mutant endonuclease V enzymes to introduce a nick into a target DNA including one or more inosine, and uses a DNA polymerase to generate amplicons of a target DNA are also described. | ||||||
| 权利要求 | |||||||
| 说明书全文 | |||||||
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