Rationally-designed single-chain meganucleases with non-palindromic recognition sequences |
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| 申请号 | US15132941 | 申请日 | 2016-04-19 | 公开(公告)号 | US10041053B2 | 公开(公告)日 | 2018-08-07 |
| 申请人 | Precision BioSciences, Inc.; | 发明人 | James Jefferson Smith; Derek Jantz; | ||||
| 摘要 | Disclosed are rationally-designed, non-naturally-occurring meganucleases in which a pair of enzyme subunits having specificity for different recognition sequence half-sites are joined into a single polypeptide to form a functional heterodimer with a non-palindromic recognition sequence. The invention also relates to methods of producing such meganucleases, and methods of producing recombinant nucleic acids and organisms using such meganucleases. | ||||||
| 权利要求 | |||||||
| 说明书全文 | |||||||
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